Clinical fMRI LEC16 Spatial Normalization - Neurometrika
Clinical fMRI LEC16 Spatial Normalization - Neurometrika
Clinical fMRI LEC16 Spatial Normalization - Neurometrika
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SPM8 for Basic and <strong>Clinical</strong> Investigators<strong>Spatial</strong> <strong>Normalization</strong>
Comparing brains
<strong>Spatial</strong> <strong>Normalization</strong>: Why?• Group averaging– Structural– Functional• Labeling
<strong>Spatial</strong> <strong>Normalization</strong>: How?• landmark based• template based• linear transformations• nonlinear transformations
<strong>Spatial</strong><strong>Normalization</strong>toTalairach Atlasusing landmarks
Standard spacesTalairach AtlasMNI/ICBM AVG152 TemplateThe MNI template follows the convention of T&T, but doesn’t match the particular brainRecommended reading: http://imaging.mrc-cbu.cam.ac.uk/imaging/MniTalairachRidgway
FIL Methods Group
EPI TemplateNormalized EPI Volume
<strong>Spatial</strong> <strong>Normalization</strong>• Direct• Indirect• Dartel
Smoothing8 mm
VBM Processing
<strong>Clinical</strong> language mapping
SPM Anatomy Toolboxhttp://www.fz-juelich.de/inb/inb-3/spm_anatomy_toolbox/
SPM Anatomy Toolbox
Volume and Surface Labelsorig.mgzT1.mgz brainmask.mgz wm.mgz filled.mgzaseg.mgzaparc+aseg.mgzhttp://surfer.nmr.mgh.harvard.edu/fswiki
Surface Overlayslh.sulc on inflated lh.curv on inflated lh.thickness on inflatedlh.sulc on piallh.curv on inflatedlh.aparc.annot on inflatedhttp://surfer.nmr.mgh.harvard.edu/fswiki
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