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What current in-vitro methods can and can nottell us15CAN PROVIDE MEASURES OF:• Dose content• Dose content uniformity throughlife• Entire droplet and particle sizedistribution• not traceable to drugsubstance by currently acceptedmethod of laser diffractometry• Spray pattern and geometryLIMITATIONS:• No standardized entry portmimicking nares and nasalvestibule• Necessary if mass fractionsare required• Mass fraction < ca. 10 μmaerodynamic diameter likely topenetrate beyond the nasopharynx• New Test Needed
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