Insulin

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DiagnosisLifestyle intervention + metforminNo HbA1c≥7% Yes acAdd basal insulin- most effectiveAdd sulfonylurea- least expensiveAdd glitazone- No hypoglycaemiaNoHbA1c≥7%NoHbA1c≥7%Yes aNoHbA1c≥7%Yes aNoHbA1c≥7%NoYes a Yes a Yes aIntensify insulin c Add glitazone b Add basal insulin Add sulfonylurea bHbA1c≥7%Add basal or intensify insulin cIntensive insulin + metformin +/- glitazone
New Treatment• GLP-1• Amylin analog• Dual PPAR agonist• Inhibition of release or action of counterregulatory hormones• Inhibition of gluconeogenesis
Page 6 and 7: Milestones for Management of Diabet
Page 8 and 9: GLOBAL PROJECTIONS FORTHE DIABETES
Page 10 and 11: ILLNESS• Absence of symptoms• I
Page 13 and 14: UKPDS demonstrated loss of glycemic
Page 15 and 16: UKPDS 35 - Association of glycemia
Page 17 and 18: Lessons from the UKPDS• Too few p
Page 19 and 20: Stages to reach and maintain thetar
Page 21 and 22: Oral antidiabetic agents:physiologi
Page 23 and 24: OHA FOR DIABETESClassEfficacy in Hb
Page 25: A consensus statement from theAmeri
Page 29 and 30: The Main Incretin• GIP (Glucose-d
Page 31 and 32: GLP-1: regulation and actionsDelaye
Page 33: What does GLP-1 1 do?• Enhance in
Page 36 and 37: Correlation between HbA1c & Plasma
Page 38 and 39: Target for ControlRisk versus benef
Page 40 and 41: • Individualised risk assessment
Page 42 and 43: Steno -2: Microvascular complicatio
Page 44 and 45: Fundamental message• Diabetes man
Page 46 and 47: DOCTORS FACTORS• Not listening to
Page 48 and 49: MULTIDISCIPLINARY CARE• Self care
Page 50: MULTIDISCIPLINARY CARE• Diabetes
Page 53: InterventionsExpecteddecrease inHbA

Insulin

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