Insulin

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The Incretin : Where they go?• Both peptides are rapidly cleaved (andthus inactivated) by enzymes• DPP-IV (Dipeptidyl peptidase)• Serum T ½ of GIP = 7 mins• Serum T ½ of GLP-1 1 = 2 mins
GLP-1: regulation and actionsDelayedGastricEmptyingMeal bolusNeuralinnervationGI TractGLP-1GLP-1 NeuroendocrineCells in Ileum↑<strong>Insulin</strong>Skeletal muscleGlucoseuptake80400500400300200100MealGLP-1<strong>Insulin</strong>Pancreatic islet00 30 60 120 180 240CNS↓ Food Intake/BW↓ Glucagon↓ HGP
Page 6 and 7: Milestones for Management of Diabet
Page 8 and 9: GLOBAL PROJECTIONS FORTHE DIABETES
Page 10 and 11: ILLNESS• Absence of symptoms• I
Page 13 and 14: UKPDS demonstrated loss of glycemic
Page 15 and 16: UKPDS 35 - Association of glycemia
Page 17 and 18: Lessons from the UKPDS• Too few p
Page 19 and 20: Stages to reach and maintain thetar
Page 21 and 22: Oral antidiabetic agents:physiologi
Page 23 and 24: OHA FOR DIABETESClassEfficacy in Hb
Page 25 and 26: A consensus statement from theAmeri
Page 27 and 28: New Treatment• GLP-1• Amylin an
Page 29: The Main Incretin• GIP (Glucose-d
Page 33: What does GLP-1 1 do?• Enhance in
Page 36 and 37: Correlation between HbA1c & Plasma
Page 38 and 39: Target for ControlRisk versus benef
Page 40 and 41: • Individualised risk assessment
Page 42 and 43: Steno -2: Microvascular complicatio
Page 44 and 45: Fundamental message• Diabetes man
Page 46 and 47: DOCTORS FACTORS• Not listening to
Page 48 and 49: MULTIDISCIPLINARY CARE• Self care
Page 50: MULTIDISCIPLINARY CARE• Diabetes
Page 53: InterventionsExpecteddecrease inHbA

Insulin

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