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Master 4.6 Answer KeyThyroid Cancer, Men II, and Genetic Testing: Checking for Understanding1. What is MEN II? Although many kinds of cancer are linked with MEN II, 100 percent of peoplewith the gene for MEN II will get cancer of what organ?MEN II is multiple endocrine neoplasia 2. People with this disease almost always develop a certain typeof thyroid cancer and may also develop other kinds, such as adrenal gland, brain, and bone cancer.2. The Alzheimer’s disease genetic test doesn’t predict Alzheimer’s disease with certainty; a personwho tests positive for E4 has only a 13-to-57-percent lifetime risk of Alzheimer’s disease. If aperson tests positive for the mutation that causes MEN II, what is the chance that the person willget thyroid cancer?100 percent.3. There is no followup medical procedure that will prevent onset of Alzheimer’s disease. Whatfollowup medical options are there for a person who has tested positive for the mutation thatcauses MEN II?The thyroid can be removed before any sign of cancer. Therefore, the person will never get thyroid cancer.Because the person doesn’t have a thyroid gland anymore, they need to take a daily medication.Copyright © 2009 Education Development Center, Inc. Exploring Bioethics.Permission granted for classroom use.4. As noted, this type of thyroid cancer is caused by an autosomal dominant mutation. What doesthis mean? (What does autosomal mean? What does dominant mean?)An autosomal gene is a gene that is not on the X or Y chromosome. If one inherits the dominant versionof the gene from one or both biological parents, he or she will develop the disease.5. Other than the predictive value of the test and the options for followup medical care, what is anotherdifference between Alzheimer’s disease and the type of thyroid cancer associated with MEN II?The most typical type of Alzheimer’s arises at older ages (age 65 or older); the type of thyroid cancerassociated with MEN II arises by a person’s 30s. Alzheimer’s involves brain degeneration; MEN II leadsto an aggressive cancer if left untreated.6. If Max were to test positive for the mutation, would he know anything more about anyone elsein his family? Explain, and be as specific as possible.If Max tests positive, that means that others in his family could also have inherited the same mutation. Forexample, his aunt and uncle could both have inherited this mutation, along with his cousins. This means thatothers in the family may want to follow up with their own genetic tests for the MEN II mutation.Teacher Support Materials, Module 4TSMPage 4-2
Master 4.7 Answer KeyWhat Impact Would Max’s Newly Discovered Mutation Have on Him and Others?Name Age 1. If Max had the mutation, what is the chance that the person belowalso inherited the mutation?Max 15 1. 100%2. What is the chance that the person would develop thyroid cancer?2. 100%Pierre 39 No additional info; married into family; assume he’s homozygous recesive (tt).Sally 9 1. 50% chance of being heterozygous (Tt);50% chance of being homozygous recessive (tt).2. 50%Diane 31 1. 50% chance of being heterozygous (Tt);50% chance of being homozygous recessive (tt).Copyright © 2009 Education Development Center, Inc. Exploring Bioethics.Permission granted for classroom use.2. 50%Lindsey 5 1. 25% chance of being heterozygous (Tt);75% chance of being homozygous recessive (tt).2. 25%Eula 80 1. 50% chance of being heterozygous (Tt);50% chance of being homozygous recessive (tt).2. 50%, but she is 80 years old and free of thyroid cancer, so she must behomozygous recessive (tt).Teacher Support Materials, Module 4TSMPage 4-3
Page 1: Master 4.3 Answer KeyMax’s Case:
Page 5 and 6: Who Should Decide Whether Max Gets
Page 7 and 8: Who Should Have Access to the Resul
Page 9 and 10: Supplementary Information on HNPCC*
Page 12 and 13: Evaluative Criteria for the Final A
Page 14 and 15: Evaluative Criteria for the Final A
Page 16: Extension (Optional)continued•c.

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