2nd CSI/JSI/KAI Joint Symposium on Immunology

2 nd <strong>CSI</strong>/<strong>JSI</strong>/<strong>KAI</strong> <strong>Joint</strong> <strong>Symposium</strong> on Immunology“Regulation of Immune Responses in Health and Diseases”Venue: Icho Kaikan, Osaka UniversityDecember 5 th (Mon)8:30-9:00 Opening RemarksKazuo Sugamura (President of <strong>JSI</strong>)Chong-Kil Lee (President of <strong>KAI</strong>)Xuetao Cao (President of <strong>CSI</strong>)9:00-10:00 Keynote lecture Chair: Dr. Kazuo SugamuraXuetao Cao (National Key Laboratory of Medical Immunoloy, China):MHC molecules in innate immune response10:00-10:15 Coffee BreakSession 1 Host pathogen interactionCo-chair: Dr. Chong-Kil Lee and Dr. Kiyoshi Takeda10:15-10:45 Koji Hase (RIKEN, Japan):Epithelial immune functions at the interface between self and non-self10:45-11:15 Zusen Fan (Chinese Academy of Sciences, China):Granzyme K inhibits replication of the influenza virus throughcleaving the nuclear transport complex importin α1/β dimer ofinfected host cells11:15-11:45 Masahiro Yamamoto (Osaka University, Japan):A Toxoplasma virulence factor ROP18 disrupts a host innate andadaptive immune linkage11:45-12:15 Zhengfan Jiang (Peking University, China):STAT6 plays a critical role in anti-viral innate immunity12:15-13:30 Lunch

Session2 Clinical ImmunologyCo-chair: Dr. Sidong Xiong and Dr. Hiroyoshi Nishikawa13:30-14:00 Zhigang Tian (University of Science & Technology of China, China):Innate Immune Receptors in NK Cells-Mediated Liver Diseases andReverse of HBV-induced systemic lifelong immunotolerance by novelimmunotherapy approach14:00-14:30 Young Chul Sung (Pohang University of Science and Technology, Korea):Nonlytic Fc-fused IL-7 as an adaptive adjuvant for induction of strong andcross-reactive antibody responses14:30-15:00 Huji Xu (Second Military Medical University, China):Genetic study of rheumatoid arthritis and ankylosing spondylitis inChinese Han patients15:00-15:30 Keishi Fujio (The University of Tokyo, Japan):Fas-FasL dependent development of autoantibody suppressiveEgr2-expressing regulatory T cells15:30-16:00 Haiyan Liu (Soochow University, China):The mechanism of acute graft-versus-host disease after allogeneichematopoietic stem cell transplantation - lessons learned fromproteasome inhibition with bortezomib16:00-16:15 Coffee BreakSession 3 Control of Innate immunityCo-chair: Dr. Zhigang Tian and Dr. Toshiyuki Takai16:15-16:45 Akinori Takaoka (Hokkaido Univeristy, Japan):Roles of ZAPS as an antiviral regulator in innate immunity16:45-17:15 Eun-Kyeong Jo (Chungnam National University, Korea):Orphan nuclear receptor small heterodimer partner negatively regulatesTLR signaling17:15-17:45 Taoyong Chen (Second Military Medical University, China):E3 Ubiquitin ligases in the regulation of TLR-triggered immune response19:00 Get together party (at Senri Hankyu Hotel)

December 6 th (Tue)Session4 Anti-tumor immunityCo-chair: Dr. Eun-Kyeong Jo and Dr. Akinori Takaoka8:30-9:00 Hiroyoshi Nishikawa (Osaka University, Japan):Regulatory T cells in anti-tumor immunity9:00-9:30 Bo Huang (Tongji Medical College, China):Microparticles: new player in tumor microenvironment9:30-10:00 Chang-Yuil Kang (Seoul National University, Korea):Myeloid derived suppressor cells(MDSC) emergence from distinctperipheral precursors10:00-10:15 Coffee BreakSession5 Auto-immunityCo-chair: Dr. Zusen FAN and Dr. Koji Hase10:15-10:45 Jiyan Zhang(Institute of Basic Medical Sciences, China):T-cell regulation as a major target for immuno-intervention in autoimmunediabetes10:45-11:15 Shunsuke Chikuma (Kyoto University, Japan):T cell-expression of Trim28 prevents development of auto-inflammatory Tcells1145-12:15 Sidong Xiong (Fudan University, China):Role and mechanism of self-DNA in the development of systemic lupuserythematosus12:15-13:30 LunchSession6 Control of Adaptive Immunity (I)Co-chair: Dr. Young Chul Sung and Dr. Tomohiro Kurosaki13:30-14:00 Tadashi Yokosuka (RIKEN, Japan):Dynamic regulation of T cell activation by TCR microclusters14:00-14:30 Sang-Kyou Lee (Yonsei University, Korea):Transcriptional interactomic inhibition of RORγt suppresses TH17differentiation and autoimmunity14:30-15:00 Yoshiko Iwai (Tokyo Medical and Dental University, Japan):BATF promotes effector CD8 T cell differentiation by regulatingepigenetic remodeling and energy metabolism through Sirt1 expression

15:00-15:30 Bing Sun (Institute Pasteur of Shanghai, China):ECM1 controls Th2 cell egress from lymph nodes through re-expression ofS1P115:30-15:45 Coffee BreakSession7 Control of Adaptive Immunity (II)Co-chair: Dr. Haiyan Liu and Dr. Tadashi Yokosuka15:45-16:15 Toshiyuki Takai (Tohoku University, Japan):Regulation of TLR9 and autoimmunity by PirB, a multiligand inhibitoryreceptor16:15-16:45 Chong-Kil Lee (Chungbuk National University, Korea):Regulation of T cell responses via modulation of MHC-restricted antigenpresentation16:45-17:15 Yoshihiro Baba (Osaka University, Japan):Essential role of Ca2+ influx in B cell regulatory function17:15-17:30 Closing remarks