Osteoporosis - Hong Kong Physiotherapy Association

NOF GuidelineAntiresorptive agents• Low bone mass with secondary causesassociated with high risk of fracture ( suchas steroid use or total immobilization )• Low bone mass and 10-yr probability of hipfracture >3% or a 10-yr probability of anymajor osteoporosis related fracture >20%based on the WHO model45• Bisphosphonates- Alendronate- Risedronate- Ibandronate ( oral and IV )- Zoledronate (IV)• Selective Estrogen Receptor Modulators(SERM)- Raloxifene• Strontium * ( dual action )• Calcitonin• HRT46Anabolic agentBisphosphonate• PTH 1-34 ( Parathyroid hormone )• Inhibitors of osteoclast activity• Strong affinity for calcium ions and arerapidly taken up by bone• Long skeletal half life• ??? Long term side effects – oversuppressed bone turnover4748