The pathology of malaria

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Sequestration• Caused by P. falciparum only- Leads to under estimation of disease.-Main causes : loss of RBCs deformability +cytoadherence.-The latter occurs in capillaries & post capillaryvenules.?Modulated by the spleen. Others:Thrombospondin (platelets),CD36(leucocytes),a membrane glycoprotein and cytokines(TNF)
Possible Host Receptors• CD36• Ig super-family- ICAM-1 (CD 45) intercellular adhesion molecule- VCAM-1 (CD106) vascular cell adhesion molecule- PECAM-1 (CD31) Platelet endothelial cell adhesionmolecule• E-selectin (CD62E) endothelial-leukocyte adhesion molecule1• Thrombospondin 'thrombin-sensitive protein'(TSP)antiangiogenic• Chondroitin sulfate A sulfated glycosaminoglycan (GAG)• Hyaluronic acid• Rosetting Receptors- CR-1 (complement)- glycosaminoglycan- blood group A Source: tulane.edu
Page 1 and 2: ProfessorAhmed A.Mohamedani
Page 4 and 5: Introduction• The pigment is then
Page 6 and 7: Changes in the RBCS• The parasite
Page 10 and 11: Several Parasite Proteins Are Assoc
Page 12 and 13: Sequestrationand cytoadherenceSourc
Page 14 and 15: Prolonged shock
Page 16 and 17: Hyperparasitesaemia
Page 18 and 19: WHO definitions for severe malaria
Page 20 and 21: Pathogenesis of Falciparum malaria
Page 22: Cerebral malaria• Occurs with fal
Page 25 and 26: Cerebral Malaria• Possible pathog
Page 27 and 28: Malaria & Blood Changes-Anaemia•
Page 29 and 30: Severe anemiaSource: Essential mala
Page 31 and 32: Malaria & Blood Changes• Coagulat
Page 33 and 34: Black Water Fever• It is more com
Page 35 and 36: Black Water Fever• Therefore the
Page 38 and 39: Some Biochemical Derangements• Hy
Page 40: The liver in malaria• Enlarged &
Page 43 and 44: The Spleen in Malaria• Enlarges ,
Page 45 and 46: scarringcryoglobulinemia25°C 4°Cw
Page 47 and 48: The Kidneys & Quartan Malaria• Qu
Page 49 and 50: The lungs & MalariaCauses pulmonary
Page 51 and 52: Adrenals ,GIT, Pancreas & Heart in
Page 53 and 54: Who:Laboratory indicators of poor p
Page 55 and 56: 4. A. A. Mohamedani, O. Khalafalla
Page 57 and 58: 8. BAKRI Y. M. NOUR*,MD, PÈTRA F.

The pathology of malaria

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