MSDS for HR2-819 - Hampton Research

Material Safety Data SheetMSDS Update: 08/23/2012Version: 2.0Date Printed:SECTION 1 - Chemical Product & Company IdentificationProduct Name 1.0 M Imidazole pH 7.0Product NumberHR2-819CompanyHampton ResearchStreet Address34 JourneyCity, State, Zip, CountryAliso Viejo, CA 92656-3317 USATechnical Phone 949 425 1321Fax 949 425 1611Emergency Phone 949 425 1321For CHEMTREC Assistance, call: 800 424 9300For International CHEMTREC Assistance, call: 703 527 3887SECTION 2 - Hazards IdentificationEMERGENCY OVERVIEW• OSHA HazardsHarmful by ingestion, Corrosive, Teratogen• GHS ClassificationAcute toxicity, Oral (Category 4)Skin corrosion (Category 1B)Serious eye damage (Category 1)Reproductive toxicity (Category 1B)• GHS Label elements, including precautionary statementsPictogramSignal wordHazard statement(s)H302H314H360DangerHarmful if swallowed.Causes severe skin burns and eye damage.May damage fertility or the unborn child.Precautionary statement(s)P201P208P305 + P351 + P338P310Obtain special instructions before use.Wear protective gloves/ protective clothing/ eye protection/ face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contactlenses, if present and easy to do. Continue rinsing.Immediately call a POISON CENTER or doctor/ physician.1.0 M Imidazole pH 7.0 - HR2-819 www.hamptonresearch.com Page 1 of 9

(CONTINUED) SECTION 2 - Hazards IdentificationHMIS CLASSIFICATIONHEALTH HAZARD: 3CHRONIC HEALTH HAZARD: *FLAMMABILITY: 1PHYSICAL HAZARDS: 0NFPA RATINGHEALTH HAZARD: 3FIRE: 1REACTIVITY HAZARD: 0POTENTIAL HEALTH EFFECTS• INHALATION: May be harmful if inhaled. Material is extremely destructive to the tissue of the mucousmembranes and upper respiratory tract.• SKIN:Harmful if absorbed through skin. Causes skin burns.• EYES: Causes eye burns.• INGESTION: Harmful if swallowedFor additional information on toxicity, please refer to SECTION 11.SECTION 3 - Composition / Information on IngredientSubstance Name Synonyms Formula Mr CAS # EC # PubChemSubstance IDImidazole• 1,3-Diaza-2,4-cyclopentadiene• GlyoxalineC 3 H 4 N 2 68.08 288-32-4 206-019-2 24880372MDL # RTECS Merck Beilstein SARA Registration #MFCD00005183 NI3325000 13,4935 103853 No 01-2119485825-24-XXXXSECTION 4 - First Aid MeasuresGENERAL ADVICE• Consult a physician. Show this safety data sheet to the doctor in attendance. Move out of dangerous area.ORAL EXPOSURE• Do NOT induce vomiting. Never give anything by mouth to an unconscious person.• Rinse mouth with water. Consult a physician immediately.INHALATION EXPOSURE• If inhaled, remove to fresh air. If not breathing give artificial respiration.• If breathing is difficult, GIVE OXYGEN. Consult a physician.1.0 M Imidazole pH 7.0 - HR2-819 www.hamptonresearch.com Page 2 of 9

(CONTINUED) SECTION 4 - First Aid MeasuresDERMAL EXPOSURE• Take off contaminated clothing and shoes immediately.• Wash off with soap and plenty of water.• Consult a physician.EYE EXPOSURE• In case of contact with eyes, flush with copious amounts of water for at least 15 minutes.• Assure adequate flushing by separating the eyelids with fingers.• Continue rinsing eyes during transport to hospital.• Consult a physician.SECTION 5 - Fire Fighting MeasuresCONDITIONS OF FLAMMABILITY• Not flammable or combustible.SUITABLE EXTINGUISHING MEDIA• Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS• Wear self contained breathing apparatus for fire fighting if necessary.HAZARDOUS COMBUSTION PRODUCTS• Hazardous decomposition products formed under fire conditions. - Carbon oxides, nitrogen oxides (NOx),Hydrogen cyanide (hydrocyanic acid)SECTION 6 - Accidental Release MeasuresPROCEDURE(S) OF PERSONAL PRECAUTIONS• Use personal protective equipment.• Avoid dust formation.• Avoid breathing dust. Avoid breathing vapors, mist or gas.• Ensure adequate ventilation.• Evacuate personnel to safe areas.ENVIRONMENTAL PRECAUTIONS• Prevent further leakage or spillage if safe to do so. Do not let product enter drains.METHODS FOR CLEANING UP• Pick up and arrange disposal without creating dust. Sweep up and shovel.• Keep in suitable, closed containers for disposal.• Ventilate area and wash spill site after material pickup is complete.1.0 M Imidazole pH 7.0 - HR2-819 www.hamptonresearch.com Page 3 of 9

SECTION 7 - Handling & StoragePRECAUTIONS FOR SAFE HANDLING• Avoid contact with skin and eyes. Avoid formation of dust and aerosols• Provide appropriate exhaust ventilation at places where dust is formed.CONDITIONS FOR SAFE STORAGE• Keep container tightly closed in a dry and well-ventilated place.SECTION 8 - Exposure Controls / PPEENGINEERING CONTROLS• Contains no substances with occupational exposure limit values.PERSONAL PROTECTIVE EQUIPMENT• Respiratory: Where risk assessment shows air-purifying respirators are appropriate use a full-face particlerespirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineeringcontrols. If the respirator is the sole means of protection, use a full-face supplied airrespirator. Use respirators and components tested and approved under appropriate governmentstandards such as NIOSH (US) or CEN (EU).• Hand Protection: Handle with gloves. Gloves must be inspected prior to use. Use proper glove removaltechnique (without touching glove’s outer surface) to avoid skin contact with this product.Dispose of contaminated gloves after use in accordance with applicable laws and goodlaboratory practices. Wash and dry hands.Immersion protectionMaterial: Nitrile rubberMinimum layer thickness: 0.11 mmBreak through time: > 480 minMaterial tested:Dermatril ® (Aldrich Z677272, Size M)Splash protectionMaterial: Nitrile rubberMinimum layer thickness: 0.11 mmBreak through time: > 30 minMaterial tested:Dermatril ® (Aldrich Z677272, Size M)data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 873000,e-mail sales@kcl.de, test method: EN374If used in solution, or mixed with other substances, and under conditions which differ from EN374, contact the supplier of the CE approved gloves. This recommendation is advisory only andmust be evaluated by an Industrial Hygienist familiar with the specific situation of anticipateduse by our customers. It should not be construed as offering an approval for any specific usescenario.• Eye Protection: Face shield and safety glasses Use equipment for eye protection tested and approved underappropriate government standards such as NIOSH (US) or EN 166(EU).• Skin and Body Protection: Complete suit protecting against chemicals, The type of protective equipmentmust be selected according to the concentration and amount of the dangerous substance at thespecific workplace.• Hygiene measures: Handle in accordance with good industrial hygiene and safety practice. Wash handsbefore breaks and at the end of workday.1.0 M Imidazole pH 7.0 - HR2-819 www.hamptonresearch.com Page 4 of 9

SECTION 9 - Physical / Chemical PropertiesAPPEARANCE FORM: crystallineCOLOR:white, light yellowPROPERTYVALUEMolecular Weight 68.08pHBoiling PointMelting Point / Freezing PointFlash PointIgnition TemperatureAutoignition TemperatureLower Explosion LimitsUpper Explosion LimitsVapor PressureDensityWater SolubilityPartition Coefficient: n-octanol/waterRelative Vapor DensityOdorOdor ThresholdEvaporation RateN/A256°C (493 °F)88 - 91°C (190 - 196 °F)> 135°C (> 275°F) - ISO 2719 - see user defined free text480°C (896°F)N/AN/AN/A0.003 hPa (0.002 mmHg) at 20 °C (68 °F)N/A6.8 g/l at 20°C (68°F) - completely soluble633 g/l at 20°C (68°F)log Pow: -0.02 at 25°C (77°F)N/Aamine-likeN/AN/AN/A = NOT AVAILABLESECTION 10 - Stability & ReactivityCHEMICAL STABILITY• Stable under recommended storage conditions.POSSIBILITY OF HAZARDOUS REACTIONS• No data availableCONDITIONS TO AVOID• No data availableMATERIAL TO AVOID• Materials to Avoid: Acids, Acid anhydrides, Strong oxidizing agents.HAZARDOUS DECOMPOSITION PRODUCTS• Hazardous decomposition products formed under fire conditions.- Carbon oxides, nitrogen oxides (NOx), Hydrogen cyanide (hydrocyanic acid)• Other decomposition products - no data available1.0 M Imidazole pH 7.0 - HR2-819 www.hamptonresearch.com Page 5 of 9

(CONTINUED) SECTION 11 - Toxicological InformationSIGNS & SYMPTOMS OF EXPOSURE• To the best of our knowledge, the chemical, physical, and toxicological properties have NOT been thoroughlyinvestigated.SYNERGISTIC EFFECTS: No data availableADDITIONAL INFORMATION: RTECS: NI3325000SECTION 12 - Ecological InformationTOXICITY• Toxicity to fish• Toxicity to daphniaand other aquaticinvertebrates• Toxicity to algae• Toxicity to bacteriastatic test LC50 - Leuciscus idus (Golden orfe) - 280 mg/l - 48 hEC50 - Daphnia - 341.5 mg/l - 48 hstatic test EC50 - Scenedesmus quadricauda (Green algae) - 133 mg/l - 72 hsee user defined free text - other microorganisms - 45 mg/l - 0.5 hELIMINATION INFORMATION (PERSISTENCE AND DEGRADABILITY)• BiodegradabilityaerobicResult: 86 % - Readily biodegradable.BIOACCUMULATIVE POTENTIAL• No data availableMOBILITY IN SOIL• No data availablePBT and vPvB ASSESSMENT• No data availableOTHER ADVERSE EFFECTS• No data availableSECTION 13 - Disposal ConsiderationsAPPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION• Offer surplus and non-recyclable solutions to a licensed disposal company.• Contact a licensed professional waste disposal service to dispose of this material.• Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with anafterburner and scrubber.• Observe all federal, state, and local environmental regulations.CONTAMINATED PACKAGING• Dispose of as unused product.1.0 M Imidazole pH 7.0 - HR2-819 www.hamptonresearch.com Page 7 of 9

SECTION 14 - Transportation InformationDOT (US)• UN-Number: 3263 • Class: 8 • Packing Group: II• Proper Shipping Name: Corrosive solid, basic, organic, n.o.s. (Imidazole)• Marine pollutant: No• Poison Inhalation Hazard: NoIMDG• UN-Number: 3263 • Class: 8 • Packing Group: II • EMS-No: F-A, S-B• Proper Shipping Name: CORROSIVE SOLID, BASIC, ORGANIC, N.O.S. (Imidazole)• Marine Pollutant: NoIATA• UN-Number: 3263 • Class: 8 • Packing Group: II• Proper Shipping Name: Corrosive solid, basic, organic, n.o.s. (Imidazole)SECTION 15 - Regulatory InformationOSHA HAZARDS• Harmful by ingestion., Corrosive, TeratogenSARA 302 COMPONENTS• SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title III, Section302.SARA 313 COMPONENTS• SARA 313: This material does not contain any chemical components with known CAS numbers that exceedthe threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 HAZARDS• Acute Health Hazard, Chronic Health HazardMASSACHUSETTS RIGHT TO KNOW COMPONENTS• No components are subject to the Massachusetts Right to Know Act.PENNSYLVANIA RIGHT TO KNOW COMPONENTS• Imidazole: CAS-No: 288-32-4 Revision Date:NEW JERSEY RIGHT TO KNOW COMPONENTS• Imidazole: CAS-No: 288-32-4 Revision Date:CALIFORNIA PROP. 65 COMPONENTS• This product does not contain any chemicals known to State of California to cause cancer, birth, or any otherreproductive defects.1.0 M Imidazole pH 7.0 - HR2-819 www.hamptonresearch.com Page 8 of 9

SECTION 16 - Other InformationDISCLAIMER• For R&D use only. Not for drug, household, or other use.WARRANTY• The above information is believed to be correct but does no purport to be all inclusive and shall be used onlyas a guide. The information in this document is based on the present state of our knowledge and is applicableto the product with regard to appropriate safety precautions. It does not represent any guarantee of the propertiesof this product. Hampton Research Corp., shall not be held liable for any damage resulting from handlingor from contact with the above product. See reverse side of invoice or packing slip for additional terms andconditions of sale.• License granted to make unlimited paper copies for internal use only.© 1991 - 2012 Hampton Research Corp.1.0 M Imidazole pH 7.0 - HR2-819 www.hamptonresearch.com Page 9 of 9