Lupus is easy with a little practice - Professor ... - Parkside Hospital

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Rheumatoid ArthritisBiological treatment strategies• TNF inhibition– Soluble receptor antagonists:• Etanercept• Fusion proteins comprised of the p75 TNF receptor linked tothe Fc portion of the human IgG1– Monoclonal antibodies:• Infliximab• Adalimumab• Golimumab• Certolizumab– polyethylene glycolated Fab fragment. No Fc portion)
Rheumatoid ArthritisBiological treatment strategies• IL1 inhibition– Cell surface receptor antagonists:– Recombulent antagonist of IL1 receptor– Anakinra• IL6 inhibition– Cocilizumab – humanized anti-human IL6 receptor antibody• Co-stimulation blockade– Abatacept (CTLA-4 – Ig)– soluble fusion protein comprising CTLA – 4 and the Fc portion of IgG.Inhibitory signal.• B cell depletion.– Rituximab– Monoclonal anti-CD20 antibody
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Lupus is easyWith a little practice
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Lupus- Multi-systemic disease- Wide
Page 6:
What Does Lupus Look Like?
Page 19: Lupus• Musculoskeletal- Myalgia-
Page 23 and 24: Lupus• Nerves Neuropsychiatric SL
Page 25 and 26: MR Imaging and Spectroscopy of an N
Page 27 and 28: Lupus• Blood- Haemolytic anaemia-
Page 30: Lupus• Lungs- Plural Effusion- Lo
Page 34 and 35: Lupus• General management- Sun pr
Page 36 and 37: LupusImmunosuppressivemedication•
Page 38 and 39: Lupus• Belimumab• Monoclonal an
Page 40 and 41: Lupus• Is cancer risk increased i
Page 42 and 43: LupusDhydroepiandrosterone (DHEA)
Page 44 and 45: Lupus• SLE in Pregnancy- Not cont
Page 46 and 47: LupusPrognosis• Patient survival
Page 48 and 49: Lupus• Does clinical remission oc
Page 50 and 51: Rheumatoid Arthritis• The bottom
Page 52 and 53: Clinical HistorySwan Neck Deformity
Page 54 and 55: Rheumatoid Arthritis• In the last
Page 56 and 57: Rheumatoid ArthritisManagement theo
Page 58 and 59: Rheumatoid ArthritisComplexity• M
Page 60 and 61: Rheumatoid ArthritisTypical referra
Page 62 and 63: Academic RheumatoidArthritisBlood I
Page 64 and 65: Practical RheumatoidArthritisManage
Page 66 and 67: Practical RheumatoidArthritisManage
Page 70 and 71: Rheumatoid ArthritisTB & not TB: la
Page 73 and 74: Thank you for your attentionThe Lon
Page 75 and 76: Lupus• Antiphospholipid Syndrome-
Page 77 and 78: Lupus• Specific Investigations- A
Page 79 and 80: Lupus• Drug Induced Lupus- More p
Page 81: Lupus• Lupus researchScaling new
Page 84 and 85: Thank you for your attention…
Page 86 and 87: Thank you for yourattention
Page 88: What sort of arthritis?
Page 94: Please Meet Gwyneth
Page 97: ………and all the complications
Page 102: Lupus• SLE in PregnancyAdverse ou
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Lupus is easy with a little practice - Professor ... - Parkside Hospital

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