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Lupus is easy with a little practice - Professor ... - Parkside Hospital

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Rheumatoid Arthrit<strong>is</strong>Biological treatment strategies• IL1 inhibition– Cell surface receptor antagon<strong>is</strong>ts:– Recombulent antagon<strong>is</strong>t of IL1 receptor– Anakinra• IL6 inhibition– Cocilizumab – humanized anti-human IL6 receptor antibody• Co-stimulation blockade– Abatacept (CTLA-4 – Ig)– soluble fusion protein compr<strong>is</strong>ing CTLA – 4 and the Fc portion of IgG.Inhibitory signal.• B cell depletion.– Rituximab– Monoclonal anti-CD20 antibody

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