Annual Report of Activities CNC 2011 - Center for Neuroscience and ...
Annual Report of Activities CNC 2011 - Center for Neuroscience and ...
Annual Report of Activities CNC 2011 - Center for Neuroscience and ...
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Bernardino <strong>and</strong> Lino Ferreira. 6-‐ We could identify a novel role <strong>for</strong> endocannabinoids <strong>and</strong> hemoglobin-derived peptides in neurogenesis <strong>and</strong> oligodendrogenesis in SVZ neural stem cell cultures. A key action <strong>of</strong> CB1 receptors in nestin-‐positive cells was explored. Leading scientists: Sara Xapelli <strong>and</strong> João O. Malva 7-‐ We could identify a new proneurogenic action <strong>of</strong> histamine (via H1 receptors) in SVZ stem cells <strong>and</strong> to develop innovative biocompatible histamine-‐releasing microparticles. These microparticles were highly efficient in promoting differentiation <strong>of</strong> neurons from SVZ cell cultures <strong>and</strong> to promote differentiation <strong>of</strong> new neuroblasts in SVZ cell grafted into hippocampal organotypic slice cultures. Leading scientists: Liliana Bernardino, Lino Ferreira <strong>and</strong> João O. Malva 8-‐We dissected a role <strong>for</strong> endothelial BDNF signaling in neuroblast migration in the developing mice cerebellum. Leading scientist: João O. Malva; international collaboration with Armen Sagathelyan (Québec City). 9-‐We revealed a role <strong>for</strong> endothelial BDNF in re-‐routing neuroblast from the rostral migratory stream into the mice ischemic striatum. Leading scientist: João O. Malva; international collaboration with Armen Sagathelyan (Québec City). Additionally, we contributued to the successful training <strong>of</strong> young <strong>and</strong> high-quality scientists at the master, PhD <strong>and</strong> potdoctoral level. In <strong>2011</strong>, Alex<strong>and</strong>ra Rosa <strong>and</strong> Raquel Ferreira were awarded with a PhD degree. Jorge Valero <strong>and</strong> Catarina Pimentel were admited as postdoctoral fellows/investigators at our research group. Fabienne Agasse, Liliana Bernardino <strong>and</strong> Sara Xapelli concluded their postdoctoral training/<strong>CNC</strong> contract <strong>and</strong> were admited in extra-‐mural institutions, keeping a productive collaboration with <strong>CNC</strong> members at our research group. The members <strong>of</strong> our group were highly active, together with other members <strong>of</strong> the <strong>CNC</strong> <strong>and</strong> the Portuguese Society <strong>for</strong> <strong>Neuroscience</strong> (SPN), organizing a variety <strong>of</strong> activities included in Brain Awareness week <strong>and</strong> European Night <strong>of</strong> Scientists. 19
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