Chloramphenicol Palmitate - Dc Msme

40CHLORAMPHENICOL PALMITATEpotential, there is a good scope for settingup units in small scale sector.BASIS ANDPRESUMPTIONS1. The estimates are drawn for aproduction capacity generallyconsidered techno economicallyviable for a model type of manufacturingunit.2. The cost in respect of land andbuilding, machinery andequipment, raw materials and theselling prices of the Chloramphenicolpalmitate are thosegenerally obtained at the time ofpreparation of the project reportand may vary depending uponother various factors.3. The wages of the workers aretaken as per the prevailing labourwages laws.4. The plant, equipment andmachinery required for themanufacture of chloramphenicolpalmitateis either available or canbe fabricated indigenously basedon the designs, drawing andspecifications worked out for theproject.5. Interest rate for fixed and workingcapital has been taken at 14%.6. Scheme is worked out on twoshifts basis of eight hours a dayand 300 working days in a year.IMPLEMENTATION SCHEDULEPreparation of Project reportSelection of siteSSI registrationFinance/loan from bank orFinancial Institution1 month2 months1 month2 monthsPower connection/building 3 monthsconstructionMachinery procurement 3 monthsTrial run2 weeksActual Commercial Production 1 monthTECHNICAL ASPECTSProcess of ManufactureChloramphenicol is esterified bycondensing with palmitoyl chloride (CH 3(CH 2) 14COCI) in the presence ofpyridine. The crude ester is obtained bypouring the reaction product into a largeexcess of diluted Hydrochloric acid andthe whole mass is filtered. It is thenwashed with toluene dimethylformamide. The pure ester is dried,recrystallised and pulverized beforepacking. Chemical equation of thereaction is as under.H NH COCHCI 2| |O 2N – C – C– CH 2OH + CH 3(CH 2) 14COCl| |OH H ↓H NH COCHCI 2| |O 2N – C – C– CH 2OCO (CH 2) 14CH 3| |OH HQuality Control and StandardsChloramphenicol-palmitate is practicallyinsoluble in water, slightly soluble inalcohol, soluble in acetone, chloroformand solvent ether. It is fine white orgreyish white powder, it melts between87 0 to 95 0 C. It should conform to theStandard of Indian Pharmacopoeia.Production Capacity (per annum)Installed capacity : 8 MTValue : Rs. 92,00,000