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Medical chemistry and biochemistry 1. Calculations (conversions of ...

Medical chemistry and biochemistry 1. Calculations (conversions of ...

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<strong>Medical</strong> <strong>chemistry</strong> <strong>and</strong> bio<strong>chemistry</strong><strong>1.</strong> <strong>Calculations</strong> (<strong>conversions</strong> <strong>of</strong> units, osmolarity, preparation <strong>of</strong> solutions, molarity xdensity)<strong>1.</strong> Convert the following values into units mentioned in parentheses.a) 1700 ng/mL → (mg/L) [<strong>1.</strong>7 mg/L]b) 60 pmol/µL → (mmol/L) [0.06 mmol/L]c) 0.95 mg/mL → (g/L) [0.95 g/L]d) pO 2 = 115 mmHg → (Torr) [115 Torr]e) pCO 2 = 6<strong>1.</strong>8 mmHg → (kPa) [8.2 kPa]f) 180 kcal → (kJ) [753.6 kJ]2. Calculate the concentration <strong>of</strong> osmotic effective particles in MgCl 2 solution withmolar concentration 0.3 M.[0.9 osmol/L]3. The osmolarity <strong>of</strong> Na 2 HPO 4 solution is 0.9 osmol/L. What is the molarity <strong>of</strong> thissolution?[c = 0.3 mol/L]4. Calculate the concentration <strong>of</strong> osmotic effective particles in 0.1 M NaCl solution inmosm/L.[200 mosm/L]5. Native erythrocytes were placed into the following solutions:a) 0.3 M glucoseb) 0.3 M NaClc) 0.15 M glucosed) 0.15 M NaClOsmolarity <strong>of</strong> erythrocyte cytoplasm is 0.3 osm/L.In which solution(s) (mentioned above) a water will pass into erythrocytes <strong>and</strong> thesecells will be damaged?[c) it is a hypotonic solution]6. If the number <strong>of</strong> moles <strong>of</strong> toluene is 0.66 mol, what is the volume (in cm 3 ) <strong>of</strong> thetoluene? Density <strong>of</strong> toluene = 0.88 g/cm 3 , Mr (toluene) = 92[V = 69 cm 3 ]7. How many milligrams <strong>of</strong> glucose are required for preparation 0.15 L <strong>of</strong> a 12mmol/L solution? Mr (glucose) = 180[324 mg]8. If 50 µL <strong>of</strong> uric acid solution has molarity 357 µmol/L, what is the weight (inmilligrams) <strong>of</strong> uric acid in this solution? Mr (uric acid) = 168[0.003 mg]9. If 1<strong>1.</strong>3 g NaCl is dissolved in 325 mL <strong>of</strong> water, what is the weight concentration(g/L) <strong>and</strong> molarity (mol/L) <strong>of</strong> the solution?Mr (NaCl) = 58.5, density <strong>of</strong> NaCl solution = 1 g/cm 3[33.6 g/L, c = 0.57 mol/L]


10. The patient excreted 1500 mL <strong>of</strong> urine per 24 hours. Chemical analysis showsthe urine creatinine mass <strong>of</strong> 2.625 g in 1500 mL <strong>of</strong> urine. Calculate the creatininemolarity in mmol/L.Mr (creatinine) = 113[c = 15.5 mmol/L]1<strong>1.</strong> 1 liter <strong>of</strong> human blood plasma contains about 100 mmol Cl - . How many miligrams<strong>of</strong> Cl - are found in 1 mL <strong>of</strong> plasma? Ar (Cl) = 35.5[3.55 mg]12. Calculate the weight <strong>of</strong> 0.9 % NaCl solution that contains 720 mg NaCl.[80 g]13. Calculate the mass (in grams) <strong>of</strong> pure ethanol in 0.5 dm 3 <strong>of</strong> 40% solution (v/v).Density <strong>of</strong> 100% ethanol equals 0.7893 g/cm 3 .[157.86 g]14. How many grams <strong>of</strong> AgNO 3 are required for preparation 750 mL <strong>of</strong> 20 mMsolution? Mr (AgNO 3 ) = 170[2.55 g]15. How many mililiters <strong>of</strong> 68% HNO 3 are required for preparation 0.5 L <strong>of</strong> <strong>1.</strong>0 M nitricacid solution? Density 68% HNO 3 = <strong>1.</strong>4 g/mL, Mr (HNO 3 ) = 63[33.09 mL]16. Calculate the volume <strong>of</strong> 70% HClO 4 (in mL) you need for preparation <strong>of</strong> 0.5 L <strong>of</strong>0.2 M HClO 4 . An information found on the bottle <strong>of</strong> the 70% HClO 4 is followed:density = <strong>1.</strong>67 g/cm 3 , relative molar mass <strong>of</strong> HClO 4 = 100.5[8.6 mL]17. A 2 M H 2 SO 4 solution has density <strong>1.</strong>1 g/cm 3 . What is the percent by mass <strong>of</strong> thissolution? Mr (H 2 SO 4 ) = 98[17.8 %]18. What is the percent by mass concentration <strong>of</strong> a 2.81 M HNO 3 solution (density =<strong>1.</strong>18 g/cm 3 )? Mr (HNO 3 ) = 63[15 %]19. What is the molarity <strong>of</strong> 96 % H 2 SO 4 solution? Density <strong>of</strong> H 2 SO 4 solution is <strong>1.</strong>86g/cm 3 . Mr (H 2 SO 4 ) = 98[c = 18.22 mol/L]20. Calculate the molarity <strong>of</strong> 15% HCl solution. Density <strong>of</strong> HCl solution is <strong>1.</strong>047g/cm 3 . Mr (HCl) = 36.5[c = 4.3 mol/L]

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