Ventilator Ventilator-Associated Associated Pneumonia Pneumonia ...

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Gram-negative bacillusEnzymatic inactivationChange in receptorconformationβ-lactamaseFlagellumBypasspathwayDecreasedpenetrationdue toaltered porinEffluxpumpPiliGrgurich PE et al. Expt Rev Resp Med 2012; 6: 553-555
Risk Factors for MDR Pathogens Antimicrobial therapy preceding 90 days Current hospitalisation of 5 days or more High frequency of antibiotic resistance in the communityof in the specific hospital unit Presence of risk factors for HCAP:- Hospitalization for 2 days or more in the preceding 90 days- Residence in a nursing home or extended care facility- Home infusion therapy (including antibiotics)- Chronic dialysis within 30 days- Home wound care- Family member with multidrug-resistant resistant pathogen Immunosuppressive disease and/or therapyATS HAP, VAP, HCAP Guideline Am J Respir Crit Care Med 2005; 171: 388-416
Page 4: VAP Rates in the USA10.03000Mean VA
Page 8 and 9: Diagnostic Accuracy of CPIS: A Meta
Page 10 and 11: First AuthorYearSensitivity95% CITe
Page 12 and 13: Diagnosing VAP in Critically Ill Pa
Page 14: Prognostic Value in VAP1.00.8Sensit
Page 17 and 18: Quantitative vs. qualitative cultur
Page 19: Common Causes of VAP - Bronchoscopi
Page 23 and 24: 10093.3908076.5Mortality (%)7060504
Page 25 and 26: 1.00.8Mild riskSurvival0.60.4High r
Page 27 and 28: The VAP PIRO ScorePIROcomorbidities
Page 29 and 30: Short course vs. Prolonged Antibiot
Page 31 and 32: Screened patients after daily round
Page 33 and 34: 1.00.9No treatmentSurvival0.80.70.6
Page 35 and 36: Pharmacologic-based Strategies for
Page 37 and 38: 186 citations14 potentiallyeligible
Page 39: Specific Quality improvement interv

Ventilator Ventilator-Associated Associated Pneumonia Pneumonia ...

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