Ventilator Ventilator-Associated Associated Pneumonia Pneumonia ...

Short course vs. Prolonged Antibiotic TherapyOutcome/ subgroup titleNo. of studiesNo. of participantsStatistical methodEffect size28-day mortality 2 431 Odds Ratio(M-H, Random, 95% CI)Recurrence of pneumonia 3 508 Odds Ratio(M-H, Random, 95% CI)28-d antibiotic-free days 2 431 Mean Difference(IV, Random, 95% CI)ITU mortality 2 107 Odds Ratio(M-H, Random, 95% CI)Non-res. of pneumonia 1 77 Odds Ratio(M-H, Fixed. 95% CI)1.08 (0.66, 1.76)1.37 (0.87, 2.17)4.02 (2.26, 5.78)0.85 (0.37, 1.91)0.89 (0.49, 7.40)In-hospital mortality 1 401 Odds Ratio1.09 (0.71, 1.67)(M-H, Fixed, 95% CI)Recurrence - multi-resistantorganism1 110 Odds Ratio(M-H, Fixed. 95% CI)0.44 (0.21, 0.95)Duration of ITU stay 2 431 Mean Difference(IV, Random, 95% CI)Duration of hospital stay 1 30 Mean Difference(IV, Fixed, 95% CI)Duration of mech. ventilation 2 107 Mean Difference(IV, Random, 95% CI)28-day mechanical ventilationfreedays2 431 Mean Difference(IV, Random, 95% CI)Mortality-associated with VAP 1 77 Mean Difference(IV, Fixed, 95% CI)-0.01 (- 2.30, 2.27)-1.0 (-4.11, 2.11)-0.01 (-0.57, 0.55)0.47 (-0.97, 1.92)1.0 (-8.85, 10.95)Pugh R et al. Cochrane Database of Systematic Reviews 2012, Issue 2