Day 1 - US Pharmacopeial Convention
Day 1 - US Pharmacopeial Convention
Day 1 - US Pharmacopeial Convention
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SUMMARY OF THE TOXICITY OF METALS<br />
Bruce A. Fowler Ph.D., A.T.S<br />
Division of Toxicology and<br />
Environmental Medicine<br />
Agency for Toxic Substances and<br />
Disease Registry<br />
Atlanta Atlanta, GA 30333<br />
CONTEMPORARY<br />
RISK ASSESSMENT ISSUES<br />
• NEED FOR OBJECTIVE MEASURES (BIOMARKERS) OF CELL<br />
INJURY FROM TOXIC CHEMICALS THAT MORE PRECISELY LINK<br />
EXPOSURE (DOSE –ADMINISTERED ADMINISTERED OR MEASURED BY<br />
CHEMICAL ANALYSIS IN TARGET TISSUES) AND AND MECHANISMS<br />
OF TOXICITY THAT OCCUR PRIOR TO CLINICAL DISEASE<br />
• NEED FOR IMPROVED MODE OF ACTION BIOMARKER<br />
BIOMARKER-BASED BASED<br />
RISK ASSESSMENTS FOR SENSITVE SUB-POPULATIONS<br />
SUB POPULATIONS, ,<br />
MIXTURE EXPOSURES AND NEW PRODUCTS (EG.<br />
NANOMATERIALS)<br />
• TO BE OF MAXIMAL VALUE, IT IS ESSENTIAL TO ESTABLISH<br />
MECHANISTIC LINKAGES BETWEEN BIOMARKERS.<br />
BIOMARKERS.<br />
MODULATING FACTORS AND OTHER PARAMETERS OF<br />
TOXICITY<br />
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