Antimicrobial Pharmacokinetics/dynamics Bedside ... - SWAB
Antimicrobial Pharmacokinetics/dynamics Bedside ... - SWAB
Antimicrobial Pharmacokinetics/dynamics Bedside ... - SWAB
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<strong>Antimicrobial</strong> Pk/Pd: <strong>Bedside</strong> Applications inthe Critically Ill with Renal FailureIn many infections in ICU patients higher ciprofloxacin dosagesshould be used even in renal failure or alternative antibiotics shouldbe consideredTherapeutic drug monitoring may be used to optimize antibiotictherapyTDM during continuous infusion does require fewer serum samplesDuring therapeutic hypothermia cefotaxime levels are 2 times highercompared to normothermiaICU Pk/Pd data are scarceDuring CVVH: calculate maintenance dose multiplication factor orTDMClinical failure could be due to underdosingTDM maybe also for non-toxic antibioticsKnow or measure MICs for common pathogens in hospital ICUFor nontoxic antibiotics overdosing is preferable to underdosing
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