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• Touch Control with large color display• PC Control for operation via PC• Intuitive operation• Intelligent dosing elements• Karl Fischer titration and SET titration• Client-Server database thanks to tiamo• Parallel titration with tiamo• Sample Processor control• Lab Link for Intranet and Internet• Online help• Automatic reagent exchange with the unique Dosino• Fulfills GMP/GLP and FDA regulations such as 21 CFR Part 11• USB interfaces for sample changer, printer, PC keyboard, barcode reader…3

One system – two versionsThe Titrando System offers two possibilities of operation. The resulting two basic variantsare summarized below.Instrument Operation Reagent dosing841 Titrando 840 Touch Control Dosino + Dosing UnitSpace-saving setup thanks to the operation via the Touch Control and reagent dosingusing Dosino and Dosing Unit. A second dosing device does not require any additionalspace.Instrument Operation Reagent dosing841 Titrando PC Control Dosino + Dosing UnitOperation via the PC, whose capabilities can be used directly. Also here the second dosingdevice does not require any additional space.4

Water determinationwith the TitrandoKarl Fischer titrationThe Karl Fischer water determination is one of the most frequently applied laboratorymethods. In contrast to other water determination methods it is specificas well as rapid and requires no expensive equipment. With an application rangeof 0.1% to 100% water the volumetric Karl Fischer titration is used in a widevariety of fields. No matter whether you determine the water content in food,cosmetics or pharmaceutical products, the 841 Titrando is always the rightinstrument.The sophisticated control algorithm of the Titrando has been adapted to thecharacteristics of the Karl Fischer reaction and guarantees highly precise results.You can choose between a polarized alternating current (I pol ) or a definedvoltage (U pol ) to be applied to the electrode. Both working modes yield fastand precise results.Different reagents require different parameters. The 841 Titrando lets you selectthe appropriate method for each type of reagent.Combined with the easy and intuitive user guidance this is the optimal instrument for routineoperation as well as for demanding applications in research labs. With the 841 Titrando youacquire a titration system that meets all imaginable requirements and demands no compromises.Just one example: The KF icons show you at a glance whether the instrument is still busyconditioning or whether you can start the water determination.The iodine drop indicates the KF reagent addition during conditioning.Conditioning is finished and the sample can be added.The electrode test and the newly created parameter «safety stop» prevent cell run-over duringconditioning. If, for example, the electrode is not connected correctly or the titration cell is veryhumid, conditioning is stopped after a given time or a given volume of KF reagent added. Thisnew feature increases work safety in your laboratory.KF titration with 841 Titrando und 803 KF Titration Stand.The «Reagent Organizer» accommodates the solvent andwaste bottles.6

The new 803 KF Titration StandUse the 803 KF Titration Stand for stirring and manually exchanging the spent titration vesselcontents. With the integrated membrane pump, solvent can be aspirated or added without thecell having to be opened. This translates into vastly reduced conditioning times.Automatic reagent change – so very easy!The exchange of the spent KF Reagent in the titration cell can be performed manually with the803 KF Titration Stand. The automatic procedure is even more convenient: You fix the time andthe instrument carries out the automatic reagent exchange with the Dosino. In both cases,contact with harmful reagents is avoided.7

Karl Fischer alone is notenough!The SET modeThe 841 Titrando also disposes of the SET mode, which means thatpotentiometric titrations to a preset endpoint (pH value or potential)can be performed. Typical applications of the SET mode are thedeterminations of p and m values in water analysis.pH meter included!Besides the measuring input for polarized electrodes, the Titrandoalso has two electrode inputs for pH and reference electrodes. Theresolution of the measuring inputs is 0.001 pH and thus identicalto that of our precision pH meters. Ready-for-use methods for pHmeasurement as well as for electrode calibration are stored in theinstrument. In addition the electrode characteristics and the «calibrationhistory» of each sensor are memorized. Naturally, as with anypH meter, you can also measure the potential and temperature.8

Uniquely intelligent – simple to useCall up the method – press startMethod handling is a central feature of the Titrando’s operator-friendliness. Standard user methodsenable familiarization with the system and allow the Titrando to be used immediately. By using ourmethods you can profit from our many years of experience in the titration field. All titration methodsdeveloped on Metrohm Titrinos can be converted into Titrando methods automatically using a PC.As storage media for your methods, sample data and results there are the Titrando itself, a memorycard* or a PC with its numerous possibilities. This allows complete storage security to be achieved,with the prevention of method and data loss, plus an increase in operational security.Intelligence creates transparencyOperating the Titrando System is simple and intuitive. The operator guidance system can beregaded as exemplary. In addition, the following tools make life easier for the Titrando user:• The «Quick Access» function (direct parameters) allows direct access to the parameters requiredfor the given application. These parameters can come from a wide range of different areas of theinstrument program. This means that it is no longer necessary for you to click your way throughdifferent operating levels! «Quick Access» is invaluable for routine analysis.• The «Help» fixed key shows a context-related help text in the display.• The «Follow me» help function is available when working with a PC. Continuous explanationsabout the current surroundings are given in a separate window and further possible proceduresare indicated.• The standard user methods can be modified to suit your requirements. Method templates andcalculation formula templates are available for developing your own methods. Methods can bestored under meaningful method names (32 characters) and structured directories can be used;this makes sorting, identification and searching much easier.• Whereas in the expert dialog all settings are available, the routine dialog can be freely configured,i.e. it can be custom-made to meet the requirements of the particular user. This means that userscan load their «profiles» from the personal Keycard and see only those operating elements thatthey actually need.The Titrando puts an end to puzzling out the meaning ofcoded error messages. It tells you what is going on in cleartext. Not only this; it also suggests suitable measures forremedying any faults.* Commercial CompactFlash Card; non-volatile, compact data memorythat does not need any battery.9

The Titrando System at a glanceThanks to its modular concept the Titrando Systemcan be optimally adapted to any application. It meetsthe requirements of FDA Regulation 21 CFR Part 11.Profit from its intelligence and multiple communicationoptions (USB, RS 232C, Remote)!Transparent operation – thanks to specially adapteddialogs, the Titrando accelerates method developmentand simplifies routine operation.The large color screen of the Touch Control informsyou about the instrument condition and offers uniquelycomfortable operator guidance. For operation via a PCthe appearance is exactly the same.10

More intelligence: TheData Chip of the DosingUnit contains all importanttitrant data.Numerous worked-outmethods and titrationexamples make familiarizationeasier. Methodtemplates and calculationformula templates areavailable for developingyour own methods.Extended titration andevaluation parametersopen up new applications.Thanks to the sophisticatedLiquid Handling, automaticreagent exchange is nowalso possible in volumetricKF titration.The 841 Titrando workswith Dosing Units, whichare ideal for handling KFreagents.Lab Link provides access tothe Intranet and Internet.When combining tiamoand Titrando the userprofits from a Client-Serverdatabase.Parallel titration – aTitrando can work withtwo titration cells at thesame time (requires tiamo).The Titrando System canbe fully automated eitherwith the new USB SampleProcessors or the 774Oven Sample Processor.11

Reagent dosing à la carteThe space-saving DosinoTitrating means dosing intelligently. With the 841 Titrando you dose with Dosinos and DosingUnits that are attached directly onto the reagent bottle. This means that dosing requires noadditional bench space. Thanks to adapters, any reagent bottle can be used directly.The Dosino houses the latest state-of-the-art electronics and micromechanics. The Dosing Unit canbe exchanged within seconds. Thanks to its transparent housing any bubbles that may be presentin the dosing cylinder can be seen immediately and the valve position is always shown. Rinsingand preparation of the Dosing Unit can be carried out automatically; manual dismantling andcleaning are not necessary.The Dosino – the optimal KF dosing systemThanks to the «Empty» command the Dosino can be emptied completely; this avoids the cumbersomeopening and cleaning of the Dosing Unit.Once the reagent is used up, the remaining content of the cylinder can be transferred directly tothe bottle or the titration cell. The empty reagent bottle is then replaced, the Titrando executesthe «Prep» routine and the titer determination of the new reagent can be started. In contrast tothe Exchange Unit, multiple rinsing before titer determination is not necessary, which saves timeand reagents.When not being used, KF reagents tend to produce precipitates within the stopcock and tubes,requiring time-consuming cleaning operations. The «Empty» command does away with thisproblem.12

The Data Chipmakes the differenceBrainy dosing elements with certificationThe Dosing Units set new standards with regard to reliability.Increased reliability not only saves you money, but also means fewproblems. Intelligence «en miniature» in the form of an inconspicuousData Chip makes this possible. This chip is present in everynew Dosing Unit. The Titrando automatically reads from it all thedata that it needs to carry out the titration properly, i.e. type ofreagent, titer, last titer determination, shelf-life data and much more.In addition, the Titrando compares the data it has obtained withthe selected method and carries out a plausibility test. If the resultis negative then a clear error message appears.The 800 Dosino has a simple but cleverly devised display consistingof two LEDs that keep you up-to-date about the condition of thedosing system. On the Dosing Unit both the cylinder volume andthe valve position are clearly visible.Via the four contact pins on the 807 Dosing Unit'sunderside (right) the Titrando receives the informationstored on the Data Chip.In addition, the newly developed Dosing Units offer the followingadvantages:• Every Dosing Unit is provided with serial and cylinder numbers andis supplied with a certificate of its own.• The Titrando checks the preset intervals for the titer determinationof the titrant. This ensures that work is always carried out withthe exact titer.13

The Titrando in the modernlaboratorytiamo = titration and more!Instead of the PC Control Software you also have at your disposal the new titration softwaretiamo. The name stands for «titration and more» and illustrates the program's numerous abilities.In addition to the standard functions required for controlling a Titrando, tiamo offers functionalitiesthat up to now you could only dream about:• Method editor for the unrestricted creation of titration and automation sequences – even complexdeterminations are easy to master. As an example, the next sample in line can be preparedwhile the current determination is still underway.• Client-Server database for the sharing of results and methods within a titration network. Theuser also has at his disposal comprehensive evaluation, recalculation and statistics functions.• Detailed user administration with defined access rights and individual screen organization. Thenew Layout Manager allows to perfectly adapt the configuration for each user. All this makesthe operation of tiamo as easy as 1, 2, 3!Data management is knowledge managementData must always be available: either for direct information, for transfer to a data system, forfurther processing or for an audit. The data that your Titrando System provides you with can beprinted out and stored in a conventional manner. However, all advanced data management functionsare available, for example storage on a PCMCIA card 1 that is simply inserted in the TouchControl, in the PCMCIA port of the PC or an appropriate card reader.When you work with PC Control or tiamo, you can use all the storage options offered by the PCworld, for example hard drives, diskettes, CD ROMs, Intranet…On request the Titrando can produce a machine-readable PC/LIMS report. One thing is clear:As for data storage and transfer, the Titrando is a state-of-the-art instrument.Lab LinkIf you want to connect your Titrando System directly to a superior data system, there is nothing inthe way: Lab Link opens up internal networks (Intranet, LIMS 2 , LAN 3 ) to the Titrando and makesit Internet-compatible, with all that this implies. For long-term storage you can use, for example,tools such as NuGenesis Scientific Data Management System, eRecordManager and CyberLab, andthis without a PC being connected to the Titrando. The downloading of methods from companyspecificwebsites is another application of Lab Link.Never has integration into your LIMS structure been so easy!1 A CompactFlash Card with adapter is included in thestandard accessories of the Titrando. PCMCIA = PersonalComputer Memory Card International Association(International Organization for PC memory cards)2 LIMS = Laboratory Information Management System3 LAN = Local Area NetworkIs modern and looks modern: the Titrando System.14

Quality and compatibilityCompatibility and traceabilityGLP, GMP, 21 CFR Part 11 are becomingincreasingly important in day-to-day laboratorylife. The Titrando System is entirely orientedtowards quality management in the laboratoryand offers the following possibilities:• Each time that it is switched on theTitrando System carries out a self-diagnosis.• If it has been programmed accordingly thenthe instrument will remind you about anyvalidation or service work that is due.• You can enter limits for results; their observancewill be checked for each determination.• The titer of the titrant can be monitored asa function of time in both tabular form oras a graph, similar to a control card.• The «calibration history» of the sensors canbe called up. This means, for example, thatalterations to the sensor caused by aging21 CFR Part 11 as presented on the FDA website (www.fda.gov).can be recognized before they affect theresults.• All changes to the methods are documented; traceability is guaranteed.• The Titrando allows strict control of rights of access using login and password. The requirementsdefined in FDA Regulation 21 CFR Part 11 regarding «electronic signature» and «electronic record»are fulfilled in the stand-alone system using Touch Control as well as in the version controlled viaPC. This also applies to the other points contained in this regulation, namely the protection of electronicrecords against accidental or intentional alteration and complete traceability. The Titrandowith Touch Control is the only stand-alone titration system with Audit Trail. For long-term archivinga machine-readable PC/LIMS report is available.Quality management at MetrohmQuality has always been extremely important for Metrohm. On 5 th November 1993 our companyachieved the ISO 9001 certificate of quality. The Metrohm quality management system is continuallybeing perfected and checked by both internal and external audits.The Titrando System is modern. This also applies to the object-oriented development system used inits creation. The Touch Control as a color display and operational element is unique, as are the manyother innovations of the Titrando System.15

Integrated automationPerfect modularityThe possibilities for upgrading the Titrando System are nothing short of amazing. First the barefigures: The basic unit consists of a Titrando with one measuring interface. This basic unit can beextended to form a super-titrator that controls 12 burets and boasts 6 galvanically separated measuringinterfaces. Between these two extremes lies the whole spectrum of Titrando possibilities.Among them you will certainly find a Titrando System that can solve your particular applicationproblem in an optimal way. At the same time you have the certainty that your Titrando Systemwill master all your future applications as it is fully upgradable. As a result you can view the futurewith confidence.Automation pays dividends!Increasing sample numbers, time-consuming sample preparation steps and unattendedovernight operation are good reasons for using sample changers. The 841 Titrando hasthe necessary intelligence to control sample changers and offers – together with the newinstruments 814 USB Sample Processor and 815 Robotic USB Sample Processor XL – ahigh degree of automation at low investment costs.It’s amazing: You simply connect the samplechanger to the Titrando’s USB port and theworld of automation opens up to you.Besides the new USB Processors it is alsopossible to use the 841 Titrando with the774 Oven Sample Processor – thanks totiamo! Our sample changer brochuresupplies detailed information on theautomation possibilities offered by thenew sample changer generation.814 USB Sample Processor with 841 Titrando16

Overview of 841 TitrandoDosing elementsAttachment of additional dosing elementsIntelligent Dosing Unit with integral Data ChipDosing steps per cylinder volume (resolution)Operation, dialogStirrers, titration standAttachment of Dosimats, Dosinos, stirrersSample Changer attachmentAttachment of balances, printer, PC, PC keyboard,barcode reader and/or Lab LinkPCMCIA memory-card port for methods, results, Keycard(user identification), backup8 MB CompactFlash Card with a large number ofuser methodsTemperature sensorReal-time curve display on Touch Control(90 mm x 120 mm color graphics LCD) or PC screenSET Titration to preset endpoints with automaticconditioningKF Volumetric Karl Fischer titration with automaticconditioningMEAS Measuring mode for pH, U/mV, T/°CCAL Calibration with automatic buffer recognitionSecond, galvanically separated measuring interfacefor pH, U/mV, T/°CI pol and U pol – integrated programmable PolarizerSequences can be freely programmed by the userMethod and sample data memory, result memory,databaseDialog languages: English and German; additionallanguages can easily be addedComprehensive GLP/GMP functions; meets requirementsof FDA 21 CFR Part 11Intelligent dosing devices (world novelty)Check for result limitsAccess control by means of login with passwordprotection, «Electronic Signature»Liquid handling with expanded dosing instructionsfor the 800 DosinoAutomatic reagent exchangeSpace for two 800 Dosinoswith 807 Dosing Unit12 x 800 Dosinowith 807 Dosing Unit•Dosino 800: 10’000Touch Control or PC Control (threeTitrandos can be attached to each)4 x 801 Magnetic Stirrer or 4 x 802Rod Stirrer with 804 Titration Standor 803 KF Titration Stand4 MSB connectors(Metrohm Serial Bus, Daisy Chain)1 sample changer via USBVia 2 USB Slave Ports,RS 232 Box USB (option)••Pt 1000 or NTC•••Resolution: 0.001 pH, 0.1 mV, 0.1 °CMeasuring interval: 100 ms•Option••••••••••17

Ordering information, optionsTitrando 8412.841.0010 841 Titrando with one measuring interface; with comprehensive accessoriesincluding titration vessel and indicator electrode2.840.0100 840 Touch Control for 841 Titrando6.6050.200 PC Control software for 841 Titrando, including Hardware DongleOptions2.801.0040 801 Magnetic Stirrer2.803.0010 803 KF Titration Stand6.2051.030 Holder for 840 Touch Control6.2834.030 Foils for 840 Touch Control, 3 pieces6.2133.010 Batteries 1.5 V LR6 for Touch Control, 2 pieces6.2247.000 Adapter CompactFlash Card – PCMCIA port (included in the standard accessories)6.2247.010 CompactFlash Card 8 MB (empty; the standard accessories include a card withuser methods)6.2148.010 Remote Box MSB6.2148.020 RS 232-Box USB6.2151.000 Cable USB A plug – Mini-DIN plug, 8 pins6.2151.010 Extension cable Mini-DIN socket – Mini-DIN plug, length 2 m6.2151.020 Cable USB A plug – USB B plug, length 1.8 m6.2151.030 Cable USB A plug – USB B plug, length 30 cm2.825.0010 825 Lab Link2.800.0010 800 Dosino for 841 Titrando6.2061.010 Reagent Organizer, holds two additional 1 L bottles; for dosing with Dosinos andDosing Units18

Intelligent 807 Dosing Units equipped with Data Chip; with glass cylinder for 800 Dosino,including accessories and two buret tips, one of them with micro outlet valve6.3032.120 Buret volume 2 mL6.3032.150 Buret volume 5 mL6.3032.210 Buret volume 10 mL6.3032.220 Buret volume 20 mL6.3032.250 Buret volume 50 mL19

IonanalysisMetrohm Ltd.CH-9101 Herisau/SwitzerlandPhone +41 71 353 85 85Fax +41 71 353 89 01www.metrohm.cominfo@metrohm.comwww.titrando.comSubject to modificationsDesign Ecknauer+Schoch ASW, printed in Switzerland by Metrohm Ltd., Herisau8.841.6003 – 2004-03