B Zellen und Antigene - University Institute of Immunology

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Learning Goals• Repetition• Effector functions of antibodies• Pathways of complement activation• MAC• Functions of complement• Mucosal Immunity2
Repetition• Antibodies are produced by B lymphocytes and plasma cells inthe lymphoid organs and bone marrow, but antibodies performtheir effector functions at sites distant from their production.• The antibodies that mediate protective immunity may be derivedfrom short-lived or long-lived antibody-producing plasma cellsfollowing the activation of naive or memory B cells• Many of the effector functions of antibodies are mediated by theheavy chain constant regions of Ig molecules, and different Igheavy chain isotypes serve distinct effector functions• Although many effector functions of antibodies are mediated bythe Ig heavy chain constant regions, all these functions aretriggered by the binding of antigens to the variable regions3
Page 1: Immunologie II für Naturwissenscha
Page 5 and 6: Human Antibody IsotypesIsotype ofan
Page 7 and 8: Neutralization of microbes and toxi
Page 9 and 10: Durch Impfungen verhütbare Krankhe
Page 11 and 12: Antibody-dependent cell-mediatedcyt
Page 13 and 14: The early steps of complement activ
Page 15 and 16: The classical pathwayof complement
Page 17 and 18: Late steps of complement activation
Page 19 and 20: Functions of complement19
Page 21 and 22: Transport of IgA across epithelial
Page 23 and 24: IgA• Eigenschaften- 2. höchst im
Page 25 and 26: IgA and Antiviral Defence25
Page 27: Learning Goals• Repetition• Eff

B Zellen und Antigene - University Institute of Immunology

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