Brochure: AB SCIEX Triple Quad 5500 System

Reproducible, robust and easy to useOne touch productivitySelexION technology supports highly selective and quantitative LC/MS/MS workflows with theAB SCIEX 5500 Triple Quad and QTRAP ® 5500 Systems.• Perform a gas phase differential ion mobility separation withinthe planar ion mobility cell based on the size and shape of thecompound prior to entering the mass analyzer••On demand operation, can be turned off and on as neededwithout removing hardwareSet up or remove device within 2 minutes – without breaking• Achieve robust reproducibility for regulated bioanalysisstandards•vacuumMatch cycle times with multi-component analysis and UHPLC• Enhance resolution with integrated chemical modifiersrun timesPowerful, workflow-driven software ties everything together to deliver a new benchmark inefficiency, throughput, and productivity to let you take full advantage of all the power that theAB SCIEX Triple Quad 5500 System puts at your fingertips. And the latest version of industrystandardAnalyst ® Software utilizes the intelligent Scheduled MRM algorithm to make the methodsetup of over 1000 analytes in a single LC analysis straightforward and simple while still generatingexceptional quantitative results.• Separate ions based on high- and low-field mobility differences1.4E+061.2E+061.0E+06Peak area Buprenorphine, CV% = 6.8%5.0E+004.5E+004.0E+003.5E+00ONE TOUCH PRODUCTIVITY SOLUTIONS8.0E+056.0E+054.0E+052.0E+05Peak area Clenbuterol, CV% = 5.6%IS corrected Peak area Buprenorphine, CV% = 1.7%IS corrected Peak area Clenbuterol, CV% = 1.6%3.0E+002.5E+002.0E+001.5E+001.0E+005.0E-010.0E+000.0E+000 100 200 300 400 500 600 700 800 900 1000The above figure of 1000 injections of spiked Buprenorphine and Clenbuterol in protein precipitated human plasma demonstrates the unique reproducibility, robustnessand stability of the SelexION technology in combination with the AB SCIEX QTRAP ® 5500 System. A total of 66 hours of consecutive analysis produced a % CV of lessthan 7% in the peak area for both Buprenorphine and Clenbuterol.Intensity, cps4.4e44.0e43.5e43.0e42.5e42.0e41.5e41.0e45000.00.0Intensity, cps9.7e53.569.0e5a) QTRAP ® 55002.948.0e57.0e53.076.0e55.0e54.0e53.0e52.0e51.0e50.02.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7Time, minb) QTRAP ® 5500 withSelexION technology2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7Time, min3.073.2110X Improved S/N10X Improved LDR100%Rel. Int. (%)100%Rel. Int. (%)a) QTRAP ® 55000%0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0 4.5 5.0 5.5Time, minb) QTRAP ® 5500 withSelexION technology0%0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0 4.5 5.0 5.5Time, min4.00DiscoveryQuant SoftwareDiscoveryQuant Software improves the speed and efficiencyof drug candidate analysis for high-throughput early ADME(absorption, distribution, metabolism, and excretion). Thesoftware’s automated tools, information-sharing capabilities, andassay setup features enable you to gain more information on ahigher number of potential compounds, significantly improvingyour lab’s ability to broaden its pharmaceutical pipeline.Cliquid ® SoftwareCliquid ® Software’s pre-configured iMethod tests and simplifieduser interface makes it easier to perform routine Food,Environmental, Forensics and Clinical Research testing. With asimple four-step workflow, pre-configured methods, built-in systemsuitability tests, and automatic reports generated according toregulatory requirements, Cliquid software both simplifies the useand accelerates the adoption of LC/MS/MS for routine testing. Theavailable MRM catalogues, containing the optimized instrumentparameters for thousands of compounds can also be used to savethe time and cost associated with method development.MultiQuant SoftwareMultiQuant Software is a powerful and easy-to-use quantitationpackage that processes MRM data for quantitative information.The software easily handles large data sets consisting of bothlarge numbers of MRM transitions and patient samples, with anemphasis on the requirements for processing protein/peptidequantitative workflows. Results can easily be exported to othersoftware packages, or use the software’s flexible reporting featuresto generate custom reports.Analyst ® SoftwareAs the world’s most commonly used LC/MS/MS instrument controlsoftware platform, Analyst ® software provides state of the artfunctionality for instrument control, data analysis and reporting.The latest version builds on this legacy by providing new featuresthat enhance both performance and ease of use.Injection of clenbuterol at 5 pg/uL in urine: (a) High chemical noise makes thedetection impossible. (b) Differential ion mobility separation (DMS) increasesselectivity and eliminates the high background producing a 10X improvement insignal-to-noise.1pg/uL injection of Pentoxifylline in plasma: (a) High chemical noise makes thedetection impossible. (b) Differential mobilirt separation (DMS) increases selectivityand eliminates the background.

You invest in our technology.We invest in your success.As the world leader in mass spectrometry, AB SCIEX solutions are backed by the industry’smost extensive service and support organization. With a network of service professionals,experienced compliance specialists, and over 150 PhD application scientists worldwide, we arededicated to supporting your technical needs and helping you get the most out of yourAB SCIEX systems.AB SCIEX service professionals are recognized as the most highly qualified in the industry.They are certified on our instrument platforms through a rigorous 4-step certification program,with re-certification occurring every two years. This award-winning program helps to ensurethat you receive the most efficient, highest-quality, and most up-to-date service available forAB SCIEX products and technology. Choose from flexible service plans and a variety of servicesfor the right level of support for your laboratory’s needs and budget.Our customer support network is available to provide expert assistance in the use and applicationof AB SCIEX products through a comprehensive range of services, including application support,technical service, and training.Whether you access our service and support team by phone, email, on-site visits, or throughour innovative remote monitoring technology, you can be confident that the AB SCIEXorganization will be there for you.For more information, visit www.absciex.comFor Research Use Only. Not for use in diagnostic procedures.AcQuRate, Curtain Gas, eQ, iMethod, Linear Accelerator, MIDAS, MRMPilot, MultiQuant, Scheduled MRM, TripleTrap, and Turbo V are trademarks and Analyst, Cliquid, LightSight,LINAC, MicroIonSpray, NanoSpray, QJet, QTRAP, and TurboIonSpray are registered trademarks of AB SCIEX.© 2011 AB SCIEX. The trademarks mentioned herein are the property of AB Sciex Pte. Ltd. or their respective owners. AB SCIEX is being used under license.0280710-02 05/2011Headquarters110 Marsh Drive | Foster City CA 94404 USAPhone 650-627-2600www.absciex.comInternational SalesFor our office locations please call the divisionheadquarters or refer to our website atwww.absciex.com/offices