Siwan Choi, M.D. Chungnam National University

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Enhanced ROS productionImpairments of NO bioavailability↓( K ATP channels, K Ca channels, K V channels )Microvascular dysfunctionEndothelial dysfunction
Microvascular alterationin chronic coronary artery diseaseIncreased levels of ET and increased sensitivity to ET -1Sustained vasoconstrictionDecreased Shear stress Mitogenic & fibrogenic growthIncreased AG II & catecholaminesVSMC hypertrophy & proliferationMicrovascular hypertrophic remodeling: Increased wall thickness and stifffnessAggravate myocardial ischemia
Page 1 and 2: Vasomotor Regulation of Coronary Ar
Page 3 and 4: Myocardial Blood Volume• 1/3 of t
Page 5 and 6: Pressure in the Coronary Circulatio
Page 7 and 8: Coronary Vascular resistance at hyp
Page 9: Coronary Vasomotor RegulationInterp
Page 12 and 13: Coronary Vasomotor RegulationInterp
Page 14 and 15: Myogenic vasoconstriction(resistant
Page 16 and 17: Myogenic ConstrictionMembrane depol
Page 18 and 19: Myogenic ConstrictionReactive oxyge
Page 20 and 21: Complex components of vascular regu
Page 22 and 23: Mediators of FMD :from Endothelium
Page 24 and 25: Nature of EDHF• H 2 O 2Proximal c
Page 30 and 31: FMD in CAD
Page 32 and 33: Contribution of EDHF,PG & NOin insu

Siwan Choi, M.D. Chungnam National University

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