163. EFFECT OF GOSSYPIN ON FORMALIN-INDUCED ...

163. 163. 163. EFFECT EFFECT OF OF OF GOSSYPIN GOSSYPIN ON ON FORMALIN-INDUCED FORMALIN-INDUCED NOCICEPTIN NOCICEPTIN NOCICEPTIN IN IN IN MICE MICE
MICE
Mosaddegh Mosaddegh MH. MH. 1 2
, , Ghasemi Ghasemi Ghasemi N. N.
1 Yazd Medical Sciences University, Yazd, Iran
2 N Ghasemi, Genetics, Yazd, Iran
164. 164. EFFECT EFFECT OF OF OLEO–GUM–RESIN OLEO–GUM–RESIN FROM FROM FERULA FERULA ASSA–FOETIDA ASSA–FOETIDA ASSA–FOETIDA ON ON RAT RAT UTERUS UTERUS SMOOTH SMOOTH MUSCLE
MUSCLE
CONTRACTION CONTRACTION - - INVITRO
INVITRO
Azadbakht Azadbakht M. M. M. 1 2 1
, , Ejtehadi Ejtehadi M. M. , , Nematollaie Nematollaie MH. MH.
1 Dept. of Pharmacognosy , Faculty of Pharmacy , Mazandaran Univ. of Med. Sciences, Sari , Iran.
2 Dept. of Pharmacology . Faculty of Medicine, Shiraz Univ. of Medical Sciences , Shiraz, Iran
165. 165. 165. CIMICIFUGA CIMICIFUGA RACEMOSA RACEMOSA L L NUTT. NUTT. AND AND ANAPHYLACTIC ANAPHYLACTIC REACTIONS, REACTIONS, INCLUDING INCLUDING FACE FACE FACE AND AND ORAL ORAL OEDEMA
OEDEMA
Frempong rempong W WW.,
W W.,
., Kiuru Kiuru A AA.,
A ., Ericsson Ericsson J., J., F FFarah
F arah M.
M.
Uppsala Monitoring Centre, Uppsala, Sweden
166. 166. DETECTION DETECTION AND AND QUANTITATION QUANTITATION OF OF COPPER COPPER BY BY SPECTROPHOTOMETERY
SPECTROPHOTOMETERY
Barazandeh Barazandeh M., M., Shamsa Shamsa F FF.
F
Tehran University of Medical Sciences, Medicinal Chemistry, Tehran, Iran
167. 167. EFFICACY EFFICACY OF OF NEOSTIGMINE NEOSTIGMINE ADMINISTRATION ADMINISTRATION IN IN CENTRAL CENTRAL ANTICHOLINERGIC ANTICHOLINERGIC ANTICHOLINERGIC SYNDROME
SYNDROME
SYNDROME
IN IN IN DATURA DATURA STRAMONIUM STRAMONIUM STRAMONIUM SELF-POISONING
SELF-POISONING
Niewiñska Niewiñska K. K. K. 1 2 3
, , , P PPoradowska-Jeszke
P oradowska-Jeszke WW
W. W , , Niewiñski Niewiñski P PP.
P
1 Department of Emergency and Disaster Medicine, Medical University, Wroclaw, Poland
2 Lower Silesian Pediatric Center, Wroclaw, Poland
3 Department of Clinical Pharmacology, Medical University, Wroclaw, Poland
169. 169. IDENTIFYING IDENTIFYING THERAPEUTIC THERAPEUTIC THERAPEUTIC PROPERTIES PROPERTIES OF OF SELECTED SELECTED MEDICINAL MEDICINAL HERBS HERBS AND AND PHYTO-PRODUCTS
PHYTO-PRODUCTS
ORIGINATED ORIGINATED IN IN IN AUSTRALASIA, AUSTRALASIA, OCEANIA OCEANIA AND AND PACIFIC PACIFIC RIM RIM COUNTRIES
COUNTRIES
Meissner Meissner Meissner H. H. 1 2 2 2 2
, , Mscisz Mscisz Mscisz A AA.
A , , , Lutomski Lutomski J. J. J. , , KK
Kedzia KK
edzia edzia B. B. B. , , , Segiet-K Segiet-K Segiet-Kujawa Segiet-K Segiet-K ujawa E. E.
1 TTD International - Australia & CSU, Sydney, Australia
2 Research Institute of Medicinal Plants, Poznañ, Poland
170. 170. INTERACTIONS INTERACTIONS OF OF HERBAL HERBAL DRUGS DRUGS WITH WITH CONVENTIONAL CONVENTIONAL CONVENTIONAL THERAPY THERAPY FOR FOR FOR NEURODEGENERATIVE
NEURODEGENERATIVE
NEURODEGENERATIVE
DISEASE DISEASE DISEASE – – CLINICAL CLINICAL CLINICAL IMPLICATIONS
IMPLICATIONS
IMPLICATIONS
O¿arowski O¿arowski M., M., Mrozikiewicz Mrozikiewicz PM.
PM.
Research Institute of Medicinal Plants, Poznan, Poland
171. 171. PRE-GELATINISED PRE-GELATINISED MACA MACA (LEPIDIUM (LEPIDIUM PERUVIANUM PERUVIANUM CHACON) CHACON) AS AS NON-HORMONAL NON-HORMONAL HERBAL
HERBAL
REMEDY REMEDY TO TO TREAT TREAT MENOPAUSAL MENOPAUSAL SYMPTOMS SYMPTOMS IN IN PRE- PRE- AND AND POST-MENOPAUSAL POST-MENOPAUSAL WOMEN
WOMEN
Meissner Meissner H. H. H. 1 2 3 3
, , Reich-Bilinska Reich-Bilinska Reich-Bilinska H. H. , , K KKedzia
K edzia B. B. , , Mscisz Mscisz A AA.
A
1 TTD International - Australia & CSU, Sydney, Australia
2 Private Gineacological Clinic, Glogow, Poland
3 Research Institute of Medicinal Plants, Poznañ, Poland
172. 172. 172. THE THE THE EFFECT EFFECT EFFECT OF OF OF TAMANU TAMANU TAMANU OIL OIL OIL (CALOPHYLLUM (CALOPHYLLUM (CALOPHYLLUM INOPHYLUM) INOPHYLUM) INOPHYLUM) ON ON ON ANAEROBIC ANAEROBIC ANAEROBIC BACTERIA BACTERIA BACTERIA ISOLATED ISOLATED
ISOLATED
FROM FROM RESPIRATORY RESPIRATORY RESPIRATORY TRACT
TRACT
Kedzia edzia edzia AA
A. AA
1 2 3
, , Mscisz Mscisz A AA.
A , , Meissner Meissner H. H. H.
1 Medical University of Gdañsk, Oral Microbiology, Gdañsk, Poland
2 Research Institute of Medicinal Plants, Poznañ, Poland
3 TTD International - Australia & CSU, Sydney, Australia
173. SHORT- AND LONG-TERM PHYSIOLOGICAL RESPONSES OF MALE AND FEMALE RATS TO TWO
DIETARY LEVELS OF PRE-GELATINISED MACA (LEPIDIUM PERUVIANUM CHACON)
Meissner Meissner H. H. 1 2 2 2
, , K KKedzia
K edzia B. B. , , Mrozikiewicz Mrozikiewicz PM. PM. , , Mscisz Mscisz A AA.
A
1 TTD International - Australia & CSU, Sydney, Australia
2 Research Institute of Medicinal Plants, Poznan, Poland
174. 174. HYPOGLYCAEMIC HYPOGLYCAEMIC EFFECTS EFFECTS OF OF OF MORUS MORUS NIGRA NIGRA L. L. LEAVES LEAVES IN IN IN NORMAL NORMAL AND AND DIABETIC DIABETIC DIABETIC RATS
RATS
Eidi Eidi M. M. M. 1 2 2
, , Eidi Eidi A AA.
A , , F FFallahyan
F allahyan F FF.
F
1 Varamin Institute/Islamic Azad University, Department of Biology, Varamin, Iran
2 Science & Research Institute, Islamic Azad University, Department of Biology, Tehran, Iran
– – –

175. 175. 175. EFFECT EFFECT OF OF ALCOHOLIC ALCOHOLIC EXTRACTS EXTRACTS GARLIC GARLIC BULBS BULBS (ALLIUM (ALLIUM SATIVUM SATIVUM L.) L.) IN IN IN THE THE ACTIVITY
ACTIVITY
OF OF HEPATIC HEPATIC ENZYMES ENZYMES IN IN IN NORMAL NORMAL AND AND DIABETIC DIABETIC RATS
RATS
Fallahyan allahyan F FF.
F 1 2 3
, , Eidi Eidi A AA.
AA
, , Eidi Eidi M. M.
1 Science & Research Institute/ Islamic Azad University, Department of Biology, Tehran, Iran
2 Science & Research Institute, Islamic Azad University, Department of biology, Tehran, Iran
3 Varamin Institute, Islamic Azad University, Department of Biology, Varamin, Iran
176. 176. HYPOGLYCEAMIC HYPOGLYCEAMIC EFFECT EFFECT EFFECT OF OF PHASEOLUS PHASEOLUS VULGARIS VULGARIS L. L. PODS PODS IN IN IN NORMAL NORMAL AND AND DIABETIC DIABETIC RATS
RATS
Eidi Eidi A AA.
AA
1 2 3
, , Eidi Eidi M. M. , , F FFallahyan
F allahyan F FF.
F
1 Science & Research Institute/ Islamic Azad University, Department of Biology, Tehran, Iran
2 Varamin Institute, Islamic Azad University, Department of Biology, Tehran, Iran
3 Science & Research Institute, Islamic Azad University, Department of Biology, Tehran, Iran
177. 177. CONTENT CONTENT AND AND FARMACOLOGICAL FARMACOLOGICAL ACTIVITY ACTIVITY OF OF PLATYCODI PLATYCODI RADIX
RADIX
Koz³owski oz³owski J., J., J., K KKêdzia
K êdzia B., B., B., Buchwald Buchwald WW
W., W ., Szczyglewska Szczyglewska D.
D.
Research Institute of Medicinal Plants, Poznañ, Poland
178. 178. MICROBIOLOGICAL MICROBIOLOGICAL RESEARCH RESEARCH ON ON THE THE EXTRACTS EXTRACTS FROM FROM THE THE ROOTS ROOTS OF OF SALVIA SALVIA MILTIORRHIZA MILTIORRHIZA BUNGE
BUNGE
Buchwald Buchwald W WW.,
W ., K KKedzia
K edzia B., B., Mscisz Mscisz A AA.,
A ., Holderna-K Holderna-Kedzia Holderna-K edzia E.
E.
Research Institute of Medicinal Plants, Poznan, Poland
179. 179. MICROBIOLOGICAL MICROBIOLOGICAL QUALITY QUALITY OF OF HERBAL HERBAL PHARMACEUTICALS PHARMACEUTICALS ASSESSED ASSESSED BY BY BIOLUMINOMETRIC
BIOLUMINOMETRIC
AND AND PHARMACOPEIAL PHARMACOPEIAL METHODS
METHODS
Mietkiewicz-Capa³a Mietkiewicz-Capa³a A AA.
A 1 1 2 2
, , , Malm Malm AA
A. AA
, , Michalski Michalski Michalski AA
A. AA
, , , Bartoszcze Bartoszcze M. M.
1 Departament of Pharmaceutical Microbiology, Medical University of Lublin, Poland
2 Military Institute of Hygiene and Epidemiology- Biological Threats Identification and Countermeasure Center, Pulawy, Poland
180. 180. IN IN VIVO VIVO EFFECTS EFFECTS OF OF GRAPEFRUIT GRAPEFRUIT AND AND ORANGE ORANGE JUICES JUICES ON ON HUMAN HUMAN HUMAN CYTOCHROME CYTOCHROME CYP2D6
CYP2D6
ENZYME ENZYME ENZYME ACTIVITY
ACTIVITY
Niewiñski Niewiñski P PP.,
P ., JaŸwiñska- JaŸwiñska-Tarnawska JaŸwiñska- arnawska E., E., Orzechowska-Juzwenko Orzechowska-Juzwenko K., K., Hurkacz Hurkacz M., M., Czarnik-Matusewicz Czarnik-Matusewicz H., H., Milejski Milejski P PP.
P
Department of Clinical Pharmacology, Wroclaw Medical University, Wroc³aw, Poland
181. 181. 181. EFFECT EFFECT OF OF MIXTURE MIXTURE OF OF 6 6 6 PLANT PLANT EXTRACTS EXTRACTS ON ON BLOOD BLOOD GLUCOSE GLUCOSE LEVEL LEVEL IN IN IN DIABETIC DIABETIC MICE MICE
MICE
Samiee Samiee F FF.,
F ., Abolhasani Abolhasani M., M., T TTaghavi
T aghavi H. H.
H.
Faculty of Biomedical Engineering, Science and Research Department, Azad University, Tehran, Iran
182. 182. EFFICACY EFFICACY AND AND SAFETY SAFETY OF OF SOY SOY ISOFLAVONES ISOFLAVONES (SOYFEM) (SOYFEM) THERAPY THERAPY ON ON MENOPAUSAL MENOPAUSAL MENOPAUSAL SYMPTOMS
SYMPTOMS
Stanosz Stanosz S., S., S., Puk Puk E., E., Stanosz Stanosz M.
M.
Pomeranian Medicine Academy, Szczecin, Poland
POSTER POSTER SESSION SESSION 4
4
183. 183. A A RANDOMIZED, RANDOMIZED, OPEN-LABELED, OPEN-LABELED, OPEN-LABELED, ACTIVE-CONTROLLED ACTIVE-CONTROLLED TRIAL TRIAL OF OF 24-WEEK 24-WEEK VERSUS VERSUS 48-WEEK 48-WEEK
48-WEEK
COURSES COURSES OF OF PEG PEG INTERFERON INTERFERON ALPHA-2B ALPHA-2B PLUS PLUS RIBAVIRIN RIBAVIRIN FOR FOR GENOTYPE-1B GENOTYPE-1B INFECTED INFECTED CHRONIC
CHRONIC
HEPATITIS HEPATITIS C C PATIENTS: PATIENTS: PATIENTS: A A PILOT PILOT STUDY STUDY STUDY IN IN TAIWAN
TAIWAN
Yu u u ML. ML. 1 2 2 2
, , , Dai Dai CY CY. CY , , , Chuang Chuang WL. WL. , , Chang Chang Chang WY WY. WY
1 Kaohsiung Medical University Hospital, Internal Medicine, Kaohsiung, Taiwan
2 Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan
184. 184. COINFECTION COINFECTION OF OF SENV-D SENV-D AMONG AMONG CHRONIC CHRONIC CHRONIC HEPATITIS HEPATITIS C C PATIENTS PATIENTS PATIENTS TREATED TREATED WITH WITH COMBINATION
COMBINATION
THERAPY THERAPY WITH WITH HIGH- HIGH- DOSE DOSE INTERFERON-ALFA INTERFERON-ALFA AND AND AND RIBAVIRIN
RIBAVIRIN
Dai Dai CY CY. CY 2 2 2 3
, , Y YYu
Y u ML. ML. , , Chuang Chuang WL. WL. , , Chang Chang WY WY. WY
1 Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan
2 Kaohsiung Medical University Hospital, Internal Medicine, Kaohsiung, Taiwan
3 Kaohsiung Medical University Hospital, internal Medicine, Kaohsiung, Taiwan
185. 185. EFFECT EFFECT OF OF INTERFERON INTERFERON ALPHA-2B ALPHA-2B ALPHA-2B AND AND RIBAVIRIN RIBAVIRIN TREATMENT TREATMENT ON ON SERUM SERUM LEVELS LEVELS OF OF OF HGF,
HGF,
TGF-ALPHA TGF-ALPHA TGF-ALPHA AND AND AND EGF EGF IN IN PATIENTS PATIENTS WITH WITH CHRONIC CHRONIC HEPATITIS HEPATITIS C
C
Janczewska-Kazek Janczewska-Kazek E. E. 1 2 2
, , Marek Marek B. B. , , Kajdaniuk Kajdaniuk D. D.
1 Medical University of Silesia, Katowice, Poland
2 Medical University of Silesia, Department of Pathophysiology, Zabrze, Poland
– – –

186. 186. 186. NUCLEAVIR NUCLEAVIR 3% 3% OPHTHALMIC OPHTHALMIC OPHTHALMIC OINTMENT OINTMENT IS IS A A NEW NEW NEW DRUG DRUG FOR FOR FOR OPHTHALMIC OPHTHALMIC HERPES
HERPES
Kevra evra M. M. 1 2 3
, , Novikova Novikova Novikova I. I. , , Chekina Chekina Chekina A AA.
A
1 Belarisian State Medical University, Minsk, Belarus
2 Belarisian State Medical University, Department of Clinical Pharmacology, Minsk, Belarus
3 Belarisian State Medical University, Department of Ophthalmology, Minsk, Belarus
187. 187. INCIDENCE INCIDENCE AND AND RISK RISK FACTORS FACTORS FOR FOR HEPATOTOXICITY HEPATOTOXICITY IN IN HIV HIV INFECTED INFECTED PATIENTS PATIENTS PATIENTS RECEIVING
RECEIVING
NEVIRAPINE NEVIRAPINE CONTAINING CONTAINING ANTIRETROVIRAL ANTIRETROVIRAL THERAPY
THERAPY
Dragovic Dragovic Dragovic G. G. 1 2
, , Jevtovic Jevtovic Jevtovic D. D.
1 School of Medicine, University of Belgrade, Belgrade, Yugoslavia
2 School of Medicine, University of Belgrade, Infective and Tropical Disease - HIV/AIDS Unit, Belgrade, Yugoslavia
188. 188. INCIDENCE INCIDENCE INCIDENCE OF OF AND AND RISK RISK FACTORS FACTORS FOR FOR ADVERSE ADVERSE DRUG DRUG REACTIONS REACTIONS IN IN HIV-INFECTED HIV-INFECTED PATIENTS
PATIENTS
RECEIVING RECEIVING PROTEASE PROTEASE INHIBITOR-CONTAINING INHIBITOR-CONTAINING THERAPY: THERAPY: PROSPECTIVE PROSPECTIVE DATA DATA -BELGRADE -BELGRADE STUDY
STUDY
POPULATION
POPULATION
Dragovic Dragovic Dragovic G. G. 1 2
, , Jevtovic Jevtovic D. D.
1 School of Medicine, University of Belgrade, Belgrade, Yugoslavia
2 School of Medicine, University of Belgrade, Infective and Tropical Disease - HIV/AIDS Unit, Belgrade, Yugoslavia
191. 191. THE THE ROLE ROLE OF OF PROTEASE PROTEASE INHIBITOR-BASED INHIBITOR-BASED ANTIRETROVIRAL ANTIRETROVIRAL REGIMENS REGIMENS WITH WITH OR OR OR WITHOUT
WITHOUT
BOOSTING BOOSTING DOSE DOSE OF OF RITONAVIR RITONAVIR IN IN DEVELOPING DEVELOPING HEPATOTOXICITY HEPATOTOXICITY IN IN HIV/AIDS HIV/AIDS PATIENTS
PATIENTS
Dragovic Dragovic Dragovic G. G. 1 2
, , Jevtovic Jevtovic D. D.
1 School of Medicine, University of Belgrade, Belgrade, Yugoslavia
2 School of Medicine, University of Belgrade, Infective and Tropical Disease - HIV/AIDS Unit - School of Medicine,
University of Belgrade, Belgrade, Yugoslavia
192. 192. ANTI-TUBERCULOSIS ANTI-TUBERCULOSIS DRUG DRUG INDUCED INDUCED HEPATOTOXICITY HEPATOTOXICITY HEPATOTOXICITY IN IN HIV HIV POSITIVE POSITIVE AND AND NEGATIVE NEGATIVE NEGATIVE PATIENTS PATIENTS
PATIENTS
Yimer Yimer G. G. 1 1 1 2 3 4 4 , , , Aseffa Aseffa Aseffa AA
A.2, AA
.2, .2, Makonnen Makonnen Makonnen E. E. E. , , , Amogne Amogne Amogne WW
W. WW
, , Y YYamuah
Y amuah L. L. L. K. K. , , , Lindquist Lindquist L. L. , , , Aklillu Aklillu Aklillu E. E. E. , , , Rane Rane Rane A AA.
A ,
,
Aderaye Aderaye G. G. 1
1 Addis Ababa University, Dept of Pharmacology, Addis Ababa
2 Armauer Hansen Research Institute (AHRI), Armauer Hansen Research Institute, Addis Ababa
3 Karolinska Institutet, Dept of Medicine, Stockholm, Sweden
4 Laboratory medicine, Karolinska Institutet, Dept of Clinical Pharmacology, Stockholm, Sweden
193. 193. HERAPEUTICAL HERAPEUTICAL ACTIVITY ACTIVITY OF OF PACOVIRINE PACOVIRINE IN IN THE THE TREATMENT TREATMENT OF OF HERPETIC HERPETIC INFECTION
INFECTION
Spinu Spinu K., K., Spinu Spinu I., I., Kintia Kintia P PP.,
P ., Birca Birca L., L., Scoferta Scoferta P PP.,
P ., Holban Holban T TT.
T
Institute of Genetics, Moldovan Academy of Sciences, National Center of Preventive Medicine, Health Ministry of the
Republic of Moldova
194. 194. 194. PACOVIRINE, PACOVIRINE, AN AN ORIGINAL ORIGINAL CHEMICAL CHEMICAL THERAPEUTICAL THERAPEUTICAL PRODUCT PRODUCT TO TO TREAT TREAT VIRAL VIRAL INFECTIONS.
INFECTIONS.
Spinu Spinu I., I., Spinu Spinu K., K., Kintia Kintia P PP.
P
Institute of Genetics, Moldovan Academy of Sciences,
National Center of Preventive Medicine, Health Ministry of the Republic of Moldova,
POSTER POSTER POSTER SESSION SESSION SESSION 5 5
5
195. 195. MYCOPHENOLIC MYCOPHENOLIC ACID ACID PHARMACOKINETICS PHARMACOKINETICS DURING DURING THE THE FIRST FIRST FIRST YEAR YEAR AFTER AFTER HEART HEART TRANSPLANTATION
TRANSPLANTATION
Kunicki unicki PK. PK. 1 1 1 2 , , , Sobieszczanska-Malek Sobieszczanska-Malek Sobieszczanska-Malek M M ., ., Piotrowska Piotrowska M. M. , , PP
Pawinski PP
awinski T T .
1 National Institute of Cardiology, Clinical Pharmacology Unit, Department of Clinical Biochemistry, Warszawa, Poland
2 Medical Academy, Department of Drug Chemistry, Faculty of Pharmacy, Warszawa, Poland
196. 196. CYCLOSPORINE CYCLOSPORINE PHARMACOKINETICS PHARMACOKINETICS DURING DURING THE THE FIRST FIRST YEAR YEAR AFTER AFTER HEART HEART HEART TRANSPLANTATION
TRANSPLANTATION
Kunicki unicki PK., PK., Sobieszczanska-Malek Sobieszczanska-Malek M., M., Piotrowska Piotrowska M.
M.
National Institute of Cardiology, Clinical Pharmacology Unit, Department of Clinical Biochemistry, Warszawa, Poland
197. 197. EFFECT EFFECT OF OF 4-HYDROXYANDROST-4-ENE-3, 4-HYDROXYANDROST-4-ENE-3, 4-HYDROXYANDROST-4-ENE-3, 17-DIONE 17-DIONE (FORMESTANE) (FORMESTANE) ON ON THE THE BILE BILE BILE SECRETION SECRETION AND
AND
METABOLISM METABOLISM OF OF 4-14C-CHOLESTEROL 4-14C-CHOLESTEROL TO TO BILE BILE ACIDS
ACIDS
Czerny Czerny B. B. 1 2 1 1 1 , , T TTeister
T eister M. M. , , Juzyszyn Juzyszyn Z.1, Z.1, Modrzejewski Modrzejewski A AA.
A , , P PPawlik
P awlik A AA.
A , , Dabrowska-Zamojcin Dabrowska-Zamojcin E. E. E. ,
Gawronska-Szklarz Gawronska-Szklarz B. B. 1
1 Pomeranian Medical University, Department of Pharmacokinetics and Therapeutic Drug Monitoring, Szczecin, Poland
2 Medical University of Silesia, Departament of Pharmaceutical Chemistry, Sosnowiec, Poland
– – –

199. 199. 199. EFFECT EFFECT OF OF TIBOLONE TIBOLONE ON ON TURNOVER TURNOVER OF OF CHOLESTEROL CHOLESTEROL TO TO BILE BILE ACIDS ACIDS IN IN IN OVARIECTOMIZED OVARIECTOMIZED RATS
RATS
Czerny Czerny B. B. 1 2 1 1 1
, , T TTeister
T Teister
eister M. M. M. , , P PPawlik
P awlik A AA.1,
A .1, Juzyszyn Juzyszyn Juzyszyn Z. Z. Z. , , Mysliwiec Mysliwiec Z. Z. , , K KKurzawski
K Kurzawski
urzawski M. M.
1 Pomeranian Medical University, Department of Pharmacokinetics and Therapeutic Drug Monitoring, Szczecin, Poland
2 Medical University of Silesia, Departament of Pharmaceutical Chemistry, Sosnowiec, Poland
200. 200. PARTICLES PARTICLES PRODUCTION PRODUCTION FOR FOR CONTROLLED CONTROLLED RELEASE RELEASE OF OF OF DRUGS
DRUGS
Kula ula K., K., K., Ciach Ciach T TT.
T
Warsawa University of Technology Faculty of Chemical and Process Engineering, Warszawa, Poland
201. 201. INTESTINAL INTESTINAL FLUID FLUID VOLUMES VOLUMES AND AND AND TRANSIT TRANSIT OF OF DRUG DRUG DOSAGE DOSAGE FORMS FORMS AS AS ASSESSED
ASSESSED
BY BY MAGNETIC MAGNETIC RESONANCE RESONANCE IMAGING
IMAGING
Siegmund Siegmund W WW.
W 1 2 2 2 3 2 2
, , Giessmann Giessmann T TT.
T , , Schiller Schiller C. C. , , FF
Froehlich F roehlich CP CP. CP , , Moennikes Moennikes H. H. , , Hosten Hosten N. N. , , WW
Weitschies W eitschies W WW.
W
1 University of Greifswald, Department of Clinical Pharmacology, Greifswald, Germany
2 University of Greifswald, Department of Clinical Pharmacolgy, Greifswald, Germany
3 University Hospital Charite, Berlin, Germany
Zoulova Zoulova J. J. 1 1 1 1 2 1 1
, , , Vybiralova Vybiralova Z. Z. , , Svoboda Svoboda Z. Z. , , Chladek Chladek J. J. , , P PPetr
P etr P PP.
P , , K KKopecky
K opecky J. J. , , Kvetina Kvetina J. J.
1 Institute of Experimental Biopharmaceutics, Hradec Kralove, Czech Republic
2 Hospital Ceske Budejovice, Ceske Budejovice, Czech Republic
203. 203. FUNCTIONAL FUNCTIONAL CHARACTERIZATION CHARACTERIZATION OF OF THE THE -24C>T -24C>T POLYMORPHISM POLYMORPHISM IN IN THE THE PROMOTER
PROMOTER
OF OF THE THE MRP2 MRP2 GENE GENE IN IN RENAL RENAL RENAL CELL CELL CELL CARCINOMA
CARCINOMA
Haenisch Haenisch Haenisch S. S. 1 2 1 1
, , Zimmermann Zimmermann U. U. U. , , , Wruck Wruck Wruck Ch. Ch. Ch. , , , Cascorbi Cascorbi Cascorbi I. I. I.
1 University Hopital Schleswig-Holstein, Kiel, Germany
2 University of Greifswald, Urologie, Greifswald, Germany
204. 204. DRUG DRUG COMPATIBILITY COMPATIBILITY AND AND AND SAFETY SAFETY IN IN IN THE THE NEONATAL NEONATAL INTENSIVE INTENSIVE CARE CARE UNIT UNIT
UNIT
Kalikstad Kalikstad B. B. 1 1 1
, , Hansen Hansen Hansen TWR. TWR. , , , Skjerdal Skjerdal Skjerdal AA
A.S. AA
.S. .S. 1 Rikshospitalet University Hospital, University of Oslo, Department of Paediatrics, Neonatal, Oslo, Norway
205. 205. EFFICACY EFFICACY EFFICACY AND AND SAFETY SAFETY OF OF EXTENDED-RELEASE EXTENDED-RELEASE FORMULATION FORMULATION OF OF FLUVASTATIN FLUVASTATIN IN IN IN TURKISH TURKISH POPULATION
POPULATION
POPULATION
Ilerigelen Ilerigelen B. B. 1 2 3 4 5 6 7 8 2
, , Uresin Uresin Uresin Y YY.
Y , , San San M. M. , , , K KKultursay
K ultursay H. H. H. , , , Guneri Guneri S. S. , , , Serdar Serdar OA OA. OA , , , Gulec Gulec S. S. , , , P PPencedemir
P encedemir H. H. H. , , , Firtina Firtina Firtina M. M.
1 Istanbul University, Cerrahpasa Faculty of Medicine, Cardiology, Istanbul, Turkey
2 Istanbul University, Istanbul Faculty of Medicine, Pharmacology and Clinical Pharmacology, Istanbul, Turkey
3 Cukurova University, Faculty of Medicine, Cardiology, Adana
4 Ege University, Faculty of Medicine, Cardiology, Izmir, Turkey
5 Dokuz Eylül University, Faculty of Medicine, Cardiology, Izmri, Turkey
6 Uludag University, Faculty of Medicine, Cardiology, Bursa, Turkey
7 Ankara University, Faculty of Medicine, Cardiology, Ankara, Turkey
8 Novartis Pharma AG, Turkey, Istanbul, Turkey
206. 206. ARTEMIFONE, ARTEMIFONE, A A NEW NEW ANTI- ANTI- MALARIA MALARIA ARTEMISININ ARTEMISININ DERIVATIVE
DERIVATIVE
Nagelschmitz Nagelschmitz J, J, V VVoith
V oith B.
B.
Bayer HealthCare AG, Institute of Clinical Pharmacology, Wuppertal, Germany
208. 208. ACCUMULATION ACCUMULATION ACCUMULATION AND AND CYTOTOXIC CYTOTOXIC CYTOTOXIC ACTIVITY ACTIVITY OF OF DIFFERENT DIFFERENT DOXORUBICIN DOXORUBICIN DOXORUBICIN FORMULATIONS
FORMULATIONS
IN IN HUMAN HUMAN CANCER CANCER CELL CELL CELL LINES
LINES
Serpe Serpe Serpe L. L. 1 1 2 1 1 3 2 1 1
, , Cavalli Cavalli Cavalli R. R. , , Guido Guido M. M. , , Canaparo Canaparo R. R. , , Muntoni Muntoni E. E. , , Gasco Gasco Gasco MR. MR. , , Mauro Mauro A AA.
A , , Eandi Eandi Eandi M. M. , , Zara Zara Zara GP GP. GP
1 University of Torino, Torino, Italy
2 IRCCS Istituto Auxologico Italiano, Division of Neurology and Neurorehabilitation, Piancavallo, Italy
3 Enviroment park, Nanovector srl, Torino, Italy
209. PLASMA METHIONINE-ENKEPHALIN AND ALPHA MELANOCYTE-STIMULATING HORMONE
CONCENTRATION AFTER THE SUBCUTANEOUS APPLICATION IN RATS
Kusturica usturica J. J. 1 1 1 2 1 1 1
, , Mulabegovic Mulabegovic N. N. , , Becic Becic Becic F FF.
F , , Mandal Mandal S. S. , , T TTodic
T odic M. M. M. , , Kapic Kapic Kapic E. E. , , Loga Loga S. S.
1 Faculty of Medicine, Institute of Pharmacology, Clinical Pharmacology and Toxicology, Sarajevo, Bosnia
2 Faculty of Pharmacy, Department of Analitical Chemistry, Sarajevo, Bosnia
– – –

210. 210. 210. HYPERFILTRATION HYPERFILTRATION - - A A CAUSE CAUSE OF OF SUBNORMAL SUBNORMAL VANCOMYCIN VANCOMYCIN CONCENTRATIONS?
CONCENTRATIONS?
Hellden Hellden Hellden A AA.
A . Odar Odar-Cederloef Odar -Cederloef I.
I.
Div. of Clinical Pharmacology at Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
211. 211. MODELING MODELING AND AND OPTIMIZATION OPTIMIZATION OF OF DRUG DRUG DELIVERY DELIVERY FROM FROM INTRATUMORALLY INTRATUMORALLY INJECTED INJECTED MICROSPHERES
MICROSPHERES
Nandipati Nandipati R. R. 1 2
, , Nandipati Nandipati S. S.
1 University of Portsmouth, Houston, USA
2 Bhagwan Mahavir Medical Research Centre, Genetics, Hyderabad, India
212. 212. NANOPARTICULATE NANOPARTICULATE SYSTEMS SYSTEMS FOR FOR BRAIN BRAIN DELIVERY DELIVERY DELIVERY OF OF DRUGS
DRUGS
Nandipati Nandipati R.
R.
University of Portsmouth, Houston, USA
213. 213. PHARMACOKINETIC PHARMACOKINETIC ANALYSIS ANALYSIS OF OF IRINOTECAN IRINOTECAN AND AND ITS ITS METABOLITES METABOLITES SN-38 SN-38 SN-38 AND AND SN-38 SN-38
SN-38
GLUCURONIDE GLUCURONIDE IN IN PATIENTS PATIENTS WITH WITH GASTROINTESTINAL GASTROINTESTINAL CARCINOMA
CARCINOMA
Merkel Merkel U. U. 1 1 2 1 2 1
, , FF
Farker FF
arker K. K. , , Ulrich Ulrich W WW.
W , , Hippius Hippius M. M. , , Hoeffken Hoeffken K. K. , , Hoffmann Hoffmann A AA.
A
1 University Hospital, Friedrich Schiller University, Institute of Clinical Pharmacology, Jena, Germany
2 Clinic of Internal Medicine, Friedrich Schiller University Jena, Germany
214. 214. BIOEQUIVALENCE BIOEQUIVALENCE STUDY STUDY OF OF TWO TWO DIFFERENT DIFFERENT FORMULATIONS FORMULATIONS OF OF A A SINGLE SINGLE DOSE DOSE OF OF CARVEDILOL
CARVEDILOL
(6.25 (6.25 MG) MG) MG) IN IN YOUNG YOUNG HEALTHY HEALTHY VOLUNTEERS
VOLUNTEERS
VOLUNTEERS
Llanos Llanos L. L. 1 1 1 1 1 2 1
, , Laosa Laosa O OO.
O , , Ochoa Ochoa D. D. , , Ramirez Ramirez E. E. , , Rubin Rubin L. L. , , Arriscado Arriscado R. R. , , Guerra Guerra P PP.
PP
1 La Paz Hospital/ Autonoma University of Madrid, clinical pharmacology, Madrid, Spain
2 Normon laboratories S.A., Madrid, Spain
POSTER POSTER SESSION SESSION 6
6
215. 215. A A A NEW NEW INOTROPIC INOTROPIC AGENT AGENT IN IN IN OFF-PUMP OFF-PUMP OFF-PUMP CARDIAC CARDIAC SURGERY
SURGERY
De De Martino Martino M., M., Senese Senese I. I.
I.
AORN "San Giovanni di Dio e Ruggi d'Aragona", Cardioanestesia, Salerno, Italy
218. 218. GABA GABA ERGIC ERGIC MECHANISMS MECHANISMS MECHANISMS IN IN IN NUCLEUS NUCLEUS NUCLEUS TRACTUS TRACTUS SOLIARIUS SOLIARIUS ON ON BARAREFLEX BARAREFLEX SENSITIVITY
SENSITIVITY
IN IN ACUTE ACUTE HYPERTENSIVE HYPERTENSIVE RATS.
RATS.
Pourshanazari ourshanazari AA AA. AA 1 2 3
, , , Alaei Alaei H. H. , , , Rafati Rafati A AA.
A
1 Rafsanlan University of Medical Sciences, Rafsanjan, Iran
2 University, Physiology, Isfahan, Iran
3 Shahid Sadughi Medical University, Physiology, Yazd, Iran
219. 219. HAEMODYNAMIC HAEMODYNAMIC EFFECTS EFFECTS OF OF OPHTALMIC OPHTALMIC TIMOLOL TIMOLOL CORRELATE CORRELATE TO TO ITS ITS CONCENTRATIONS CONCENTRATIONS IN IN PLASMA
PLASMA
Nieminen Nieminen T TT.
T 1 2 3 4 4 5 5 , , Uusitalo Uusitalo H. H. , , TT
Turjanmaa TT
urjanmaa urjanmaa V VV.
V , , Bjärnhall Bjärnhall G. G. , , Hedenström Hedenström H. H. , , Mäenpää Mäenpää J. J. , , Ropo Ropo A AA.
A ,
,
Heikkilä Heikkilä P PP.
PP
6 1 3
, , Ylitalo Ylitalo P PP.
P , , Kähönen Kähönen M. M.
1 University of Tampere, Department of Pharmacological Sciences, Tampere, Finland
2 University of Kuopio, Department of Ophtalmology, Kuopio, Finland
3 University of Tampere, Department of Clinical Physiology, Tampere, Finland
4 University of Uppsala, Departments of Neuroscience/Ophtalmology and Clinical Physiology, Uppsala, Sweden
5 Santen Oy, Tampere, Finland
6 4Pharma Ltd, Turku, Finland
220. 220. 220. INSULIN INSULIN AND AND ENDOTHELIN ENDOTHELIN SERUM SERUM LEVEL LEVEL IN IN RENOVASCULAR RENOVASCULAR HYPERTENSION
HYPERTENSION
Zaporowska-Stachowiak Zaporowska-Stachowiak I. I. 1 1 , , Bobkiewicz-K
Bobkiewicz-K
Bobkiewicz-Kozlowska Bobkiewicz-K
Bobkiewicz-Kozlowska
ozlowska T TT.
T , , , Andrys- Andrys-Wawrzyniak Andrys- awrzyniak I. I. I. 2
1 Department of Pharmacology, University of Medical Sciences, Rokietnicka 5a, Poznan, Poland
2 Department of Clinical Pharmacology, University of Medical Sciences, Poznan, Poland
222. 222. THE THE EFFECTS EFFECTS OF OF VITAMIN VITAMIN C C ON ON CORONARY CORONARY FLOW, FLOW, SUPEROXIDE SUPEROXIDE ANION ANION AND AND TBARS TBARS PRODUCTION
PRODUCTION
IN IN ISOLATED ISOLATED RAT RAT RAT HEART
HEART
Djuriæ Djuriæ A AA.
A 1 2
Jakovljeviæ Jakovljeviæ V VV.
V
1 Health Centre Vracar, Belgrade,
2 Department of Physiology, Faculty of Medicine, Kragujevac, Serbia and Montenegro
– – –

223. 223. 223. THE THE EFFECTS EFFECTS EFFECTS OF OF FOLIC FOLIC ACID ACID ON ON CORONARY CORONARY FLOW, FLOW, SUPEROXIDE SUPEROXIDE ANION ANION AND AND TBARS TBARS PRODUCTION
PRODUCTION
IN IN IN ISOLATED ISOLATED ISOLATED RAT RAT HEART
HEART
Djuriæ Djuriæ AA
A. AA
1 1
Jakovljeviæ Jakovljeviæ VV
V. VV
1 Health Centre Vracar, Belgrade,
2 Department of Physiology, Faculty of Medicine, Kragujevac, Serbia and Montenegro
224. 224. THE THE RELATIONSHIP RELATIONSHIP BETWEEN BETWEEN SERUM SERUM INSULIN INSULIN AND AND AND LEPTIN LEPTIN LEVELS LEVELS IN IN PATIENTS PATIENTS PATIENTS WITH WITH ESSENTIAL
ESSENTIAL
HYPERTENSION HYPERTENSION TREATED TREATED WITH WITH PERINDOPRIL
PERINDOPRIL
PERINDOPRIL
Zaporowska-Stachowiak Zaporowska-Stachowiak I. I. 1 2 2 1
, , Gluszek Gluszek Gluszek J. J. , , Jankowska Jankowska K. K. , , Bobkiewicz-K
Bobkiewicz-Kozlowska Bobkiewicz-K ozlowska T TT.
T
1 Poznan University of Medical Sciences, Department of Pharmacology, Poznan, Poland
2 Poznan University of Medical Sciences, Department of Arterial Hypertension, Poznan, Poland
225. 225. OCULAR OCULAR AND AND CARDIOVASCULAR CARDIOVASCULAR AUTONOMIC AUTONOMIC FUNCTION FUNCTION IN IN DIABETIC DIABETIC PATIENTS PATIENTS WITH WITH VARYING
VARYING
SEVERITY SEVERITY OF OF RETINOPATHY
RETINOPATHY
Biswas Biswas NR. NR. 1 2 3 2 2 2
, , Shivaji Shivaji D.2, D.2, Rohit Rohit S. S. , , Deepak Deepak K.K. K.K. , , Vimla Vimla M. M. , , Garg Garg S.P S.P. S.P , , Radhika Radhika T TT.
TT
1 All India Institute of Medical Sciences, New Delhi, India
2 All India Institute of Medical Sciences, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, New Delhi, India
3 All India Institute of Medical Sciences, Physiology, New Delhi, India
226. 226. THE THE EFFECT EFFECT OF OF STATINS STATINS VS. VS. EZETIMIBE EZETIMIBE ON ON ARTERIAL ARTERIAL STIFFNESS
STIFFNESS
Efrati Efrati S., S., S., Averbukh Averbukh M., M., F FFridneson
F ridneson L., L., Dishy Dishy V VV.,
V ., Y YYogev
Y ogev R., R., Golik Golik A AA.
A
Assaf Harofe Medical Center, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Israel., Zerifin
227. 227. DUAL DUAL INHIBITION INHIBITION OF OF ANGIOTENSIN ANGIOTENSIN CONVERTING CONVERTING CONVERTING ENZYME ENZYME AND AND NEUTRAL NEUTRAL ENDOPEPTIDASE
ENDOPEPTIDASE
PRODUCES PRODUCES EFFECTIVE EFFECTIVE EFFECTIVE BLOOD BLOOD PRESSURE PRESSURE CONTROL CONTROL IN IN SPONTANEOUSLY SPONTANEOUSLY HYPERTENSIVE HYPERTENSIVE RATS
RATS
Kostova ostova E. E. 1 2 2 2 3 2
, , Jovanoska Jovanoska Jovanoska E. E. E. , , Zafirov Zafirov D. D. , , Jakovski Jakovski Jakovski K. K. , , , TT
Trojacanec TT
rojacanec rojacanec J., J., Kikerkov Kikerkov Kikerkov I. I. I. , , , Slaninka Slaninka Slaninka M. M. M.
1 Medical Faculty, Skopje, Macedonia
2 Medical Faculty, Pharmacology, Skopje, Macedonia
3 Medical Faculty, pharmacology, Skopje, Macedonia
228. 228. THE THE 24 24 24 HOUR HOUR MONITORING MONITORING OF OF CHANGES CHANGES CHANGES IN IN THE THE VALUES VALUES OF OF AORTIC AORTIC BLOOD BLOOD PRESSURE
PRESSURE
IN IN HYPERTENSIVE HYPERTENSIVE PATIENTS PATIENTS FROM FROM NZOZ NZOZ TWOJA TWOJA PRZYCHODNIA
PRZYCHODNIA
Stolarczyk Stolarczyk D. D. 1 2 1 2
, , Andrys Andrys I. I. , , Brokl-Stolarczyk Brokl-Stolarczyk Brokl-Stolarczyk B. B. B. , , , Ast Ast Ast J. J.
1 NZOZ Twoja Przychodnia POZ i Specjalistyka, Poznañ, Poland
2 Department of Clinical Pharmacology at Medical Academy of Karol Marcinkowski in Poznañ, Poland
229. 229. DERMATIC DERMATIC CHANGES CHANGES CHANGES OBSERVED OBSERVED IN IN TWO TWO PATIENTS PATIENTS AFTER AFTER AFTER TICLOPIDINE TICLOPIDINE THERAPY
THERAPY
Andrys Andrys I. I. 2 1 1
, , , Brokl-Stolarczyk Brokl-Stolarczyk B. B. , , Stolarczyk Stolarczyk D. D. D.
1 NZOZ Twoja Przychodnia POZ i Specjalistyka, Poznañ, Poland
2 Department of Clinical Pharmacology at Medical Academy of Karol Marcinkowski in Poznañ, Poland
230. 230. NITRIC NITRIC OXIDE OXIDE SYNTHASE SYNTHASE ACTIVITY ACTIVITY CHANGES CHANGES IN IN CORPUS CORPUS CAVERNOSUM CAVERNOSUM OF OF CHOLESTATIC CHOLESTATIC RATS
RATS
Sadeghipour Sadeghipour H. H. H. 1 1 2 1
, , Dehghani Dehghani M. M. , , Nobakht Nobakht M. M. , , Dehpour Dehpour AR. AR.
1 Tehran University of Medical Sciences, Tehran, Iran
2 Iran University, histology, Tehran, Iran
POSTER POSTER SESSION SESSION 7 7
7
232. 232. 232. EFFECTS EFFECTS OF OF AN AN ORAL ORAL TREATMENT TREATMENT WITH WITH ATP ATP ON ON SKELETAL SKELETAL MUSCLE MUSCLE MITOCHONDRIAL MITOCHONDRIAL MITOCHONDRIAL FUNCTION FUNCTION IN IN RATS
RATS
Leblond Leblond YY
Y. YY
1 2 1 2 1 1
, , VV
Ventura-Clapier V entura-Clapier R R ., ., Angignard Angignard J. J. , , , V VVeksler
V eksler V VV.
V , , Ellot Ellot MT MT. MT , , , Leblond Leblond Leblond YY
Y. YY
1 Laboratoires Mayoly Spindler, Chatou, France
2 INSERM, Research, Chatenay Malabry, France
233. 233. ANTIOXIDANT ANTIOXIDANT EFFECTS EFFECTS OF OF CAMP- CAMP- AND AND CGMP-PHOSPHODIESTERASE CGMP-PHOSPHODIESTERASE INHIBITORS INHIBITORS IN IN RAT RAT RAT DIABE DIABE
DIABE
TES-INDUCED TES-INDUCED OXIDATIVE OXIDATIVE STRESS
STRESS
Abdollahi Abdollahi Abdollahi M. M. 1 1 1 1
, , Milani Milani E. E. , , Khorasani Khorasani Khorasani R. R. R. , , Zamani Zamani Zamani MJ. MJ.
1 Tehran University of Medical Sciences, Pharmaceutical Sciences Research Center, Tehran, Iran
– – –

234. 234. 234. QT-MEASUREMENT QT-MEASUREMENT IN IN SAFETY SAFETY ELECTROCARDIOGRAPHY: ELECTROCARDIOGRAPHY: ARE ARE AUTOMATED AUTOMATED MEASUREMENTS
MEASUREMENTS
TRULY TRULY INADEQUATE?
INADEQUATE?
De De Mey Mey Ch. Ch. 1 2
, , Gatchev Gatchev E. E.
1 ACPS - Applied Clinical Pharmacology Services, Mainz-Kastel, Germany
2 Sofia Medical University, Clinical Pharmacology & Therapeutics, Sofia,. Bulgaria
235. 235. EFFECTS EFFECTS OF OF SILDENAFIL SILDENAFIL ON ON RAT RAT IRRITABLE IRRITABLE BOWEL BOWEL SYNDROME
SYNDROME
Abdollahi Abdollahi M. M. M. 1 1 1 1 1
, , Zamani Zamani Zamani MJ. MJ. , , Rezaie Rezaie AA
A. AA
, , Sharifzadeh Sharifzadeh M. M. M. , , Mashayekhi Mashayekhi FF
F. FF
1 Tehran University of Medical Sciences, Tehran, Iran
236. 236. NO NO ALTERATION ALTERATION IN IN METHADONE METHADONE ENANTIOMERS ENANTIOMERS DISPOSITION DISPOSITION BETWEEN BETWEEN INDUCTION
INDUCTION
INDUCTION
AND AND MAINTENANCE MAINTENANCE PHASES PHASES OF OF TREATMENT
TREATMENT
Somogyi Somogyi Somogyi AA AA. AA 1,2 , , Morton Morton EB. EB. EB. 1 , , Bochner Bochner F FF.
FF
1,2 , , White White JM. JM. 1,3 , , , F FFoster
F oster DJR. DJR. 1 4
, , Eichelbaum Eichelbaum Eichelbaum M. M.
1 Dept of Clinical & Experimental Pharmacology, University of Adelaide, Australia;
2 Clinical Pharmacology Unit, Royal Adelaide Hospital, Australia;
3 Drug and Alcohol Services Council, Adelaide, Australia;
4 Dr Margarete Fischer-Bosch Institute for Clinical Pharmacology, Stuttgart, Germany.
237. 237. USE USE OF OF ZAFIRLUCAST ZAFIRLUCAST IN IN IN RABBITS RABBITS WITH WITH HEART HEART INJURY
INJURY
Kezeli ezeli T TT.
T 1 1 2 1
, , Gongadze Gongadze N. N. , , Chapichadze Chapichadze Z. Z. , , , Bakuridze Bakuridze K. K.
1 State Medical University, Tbilisi, Tunisia
2 Institute of Cardiology, Tbilisi, Tunisia
238. 238. THE THE EFFECT EFFECT OF OF OF INTRAVENOUSLY INTRAVENOUSLY INJECTED INJECTED INJECTED CDP-CHOLINE CDP-CHOLINE ON ON MYOCARDIAL
MYOCARDIAL
ISCHEMIA-REPERFUSION ISCHEMIA-REPERFUSION INJURY INJURY IN IN IN RATS RATS
RATS
Sertac Sertac Yilmaz Yilmaz Yilmaz M. M. M. , , Savci Savci VV
V. VV
Uludag University, Medical Faculty Pharmacology and Clinical Pharmacology, Bursa, Turkey
239. 239. ALISKIREN, ALISKIREN, ALISKIREN, A A A NOVEL NOVEL ORAL ORAL ORAL RENIN RENIN INHIBITOR, INHIBITOR, HAS HAS HAS NO NO INTERACTION INTERACTION WITH WITH CYTOCHROME
CYTOCHROME
P450 P450 P450 ISOENZYMES ISOENZYMES IN IN VITRO
VITRO
Vaidyanathan aidyanathan S. S. 1 2 2 3
, , Jin Jin YY
Y. Y , , , Schiller Schiller H. H. H. , , , Jensen Jensen Jensen C. C.
1 Novartis Pharmaceuticals Corporation, East Hanover, USA
2 Novartis Pharma AG, Basel, Switzerland
3 Speedel Pharma AG, Basel, Switzerland
241. 241. FATTY FATTY ACIDS ACIDS IN IN PHOSPHOLIPID PHOSPHOLIPID PHOSPHOLIPID OF OF PATIENTS PATIENTS WITH WITH RECENT RECENT ACUTE ACUTE CORONARY CORONARY SYNDROME
SYNDROME
Torres orres Rodriguez Rodriguez M., M., Leal Leal De De De Garcia Garcia Garcia M., M., Gomez Gomez ME
ME
University of Carabobo, Valencia, Venezuela
242. 242. EFFECTS EFFECTS OF OF MOXINIDINE MOXINIDINE ON ON VARIOUS VARIOUS CARDIOVASCULAR CARDIOVASCULAR PARAMETERS PARAMETERS IN IN RATS
RATS
Bakuridze Bakuridze K. K. 1 2 1 1
, , Chapichadze Chapichadze Z. Z. , , Gongadze Gongadze Gongadze N. N. N. , , Shalamberidze Shalamberidze L. L.
1 State Medical University, Tbilisi, Georgia
2 Institute of Cardiology, Tbilisi, Georgia
243. 243. 243. PALMITIC, PALMITIC, PALMITIC, STEARIC STEARIC STEARIC AND AND AND ELAIDIC ELAIDIC ELAIDIC FATTY FATTY FATTY ACIDS ACIDS ACIDS AND AND AND THEIR THEIR THEIR RELATIONSHIP RELATIONSHIP RELATIONSHIP WITH WITH WITH HDLc HDLc HDLc AND AND AND LDLc LDLc
LDLc
IN IN IN PATIENTS PATIENTS WITH WITH ACUTE ACUTE MIOCARDIC MIOCARDIC STROKE.
STROKE.
Leal Leal De De De Garcia Garcia M. M. 1 1 1 1 2 1 1 1 , , Garcia Garcia Garcia D. D. D. , , Gomez Gomez ME. ME. , , Alvarado Alvarado Alvarado M. M. , , Garcia Garcia MC MC , , T TTorres
T Torres
orres M. M. , , Angulo Angulo Angulo J. J. , , Sutil Sutil R. R. ,
,
Carrizales Carrizales Carrizales M. M. 1 1
, , Marquez Marquez Marquez M. M.
1 University of Carabobo, Valencia, Venezuela
2 University of Carababo, Pharmacology, Valencia, Venezuela
244. 244. EFFECT EFFECT OF OF ENALAPRIL ENALAPRIL ON ON SERUM SERUM LIPID LIPID PEROXIDATION PEROXIDATION AND AND VITAMIN VITAMIN E E LEVELS LEVELS IN IN RABBITS.
RABBITS.
Marquez Marquez M., M., Sutil Sutil R., R., T TTorres
T orres M., M., Carrizales Carrizales M., M., Leal Leal M., M., Y YYepez
Y epez C., C., C., Munoz Munoz M., M., Mena Mena O OO.,
O ., V VValera
V alera R.
R.
University of Carabobo, Valencia, Venezuela
245. 245. THE THE INCREASED INCREASED CONCENTRATION CONCENTRATION CONCENTRATION OF OF IL-15 IL-15 IL-15 IS IS ASSOCIATED ASSOCIATED WITH WITH POOR POOR LONG-TERM LONG-TERM LONG-TERM METABOLIC
METABOLIC
CONTROL CONTROL IN IN PATIENTS PATIENTS PATIENTS WITH WITH WITH TYPE TYPE 1 1 DIABETES DIABETES MELLITUS MELLITUS TREATED TREATED TREATED WITH WITH INTENSIVE INTENSIVE INSULIN INSULIN THERAPY.
THERAPY.
Kuczynski uczynski S., S., W WWiniarska
W iniarska H., H., Abramczyk Abramczyk Abramczyk M., M., W WWierusz
W ierusz Wysocka Wysocka B., B., Dworacka Dworacka M.
M.
Poznan University of Medical Sciences, Poznan, Poland
– – –

247. 247. INFLAMMATORY INFLAMMATORY PARAMETERS PARAMETERS IN IN RENAL RENAL RENAL TRANSPLANT TRANSPLANT PATIENTS PATIENTS PATIENTS BEFORE BEFORE AND AND AFTER AFTER CLOPIDOGREL
CLOPIDOGREL
CLOPIDOGREL
Harder Harder S., S., S., Gossmann Gossmann J., J., Graff Graff J.
J.
University Hospital Frankfurt am Main, Frankfurt Am Main, Germany
249. 249. LONG-TERM LONG-TERM LONG-TERM WELL-CONTROLLED WELL-CONTROLLED PATIENTS PATIENTS WITH WITH TYPE TYPE 2 2 DIABETES DIABETES DIABETES TREATED TREATED WITH WITH SULFONUREAS
SULFONUREAS
SULFONUREAS
ARE ARE AT AT RISK RISK OF OF MACROVASCULAR MACROVASCULAR COMPLICATIONS
COMPLICATIONS
Dworacka Dworacka M. M. 1 2 2 2 2 2
, , , W WWiniarska
W iniarska H. H. , , K KKuczynski
K uczynski S. S. , , , Abramczyk Abramczyk Abramczyk M. M. , , Borowska Borowska M. M. , , Szczawinska Szczawinska K. K.
1 Poznan University of Medical Sciences, Poznan, Poland
2 Poznan University of Medical Sciences, Pharmacology, Poznan, Poland
250. 250. MODULATION MODULATION OF OF CYTOKINES CYTOKINES SECRETION SECRETION BY BY HYPOTENSIVE HYPOTENSIVE THERAPY
THERAPY
Madej Madej A AA.
A 1 2 1 1 1 1
, , Okopien Okopien B. B. , , Zielinski Zielinski M. M. , , Krysiak Krysiak R. R. , , Haberka Haberka M. M. , , Herman Herman ZS ZS
1 Medical University of Silesia, Department of Clinical Pharmacology, Katowice, Poland
2 Medical University of Silesia, Katowice, Poland
251. 251. DISPROPORTIONATELY DISPROPORTIONATELY ELEVATED ELEVATED PROINSULIN PROINSULIN SERUM SERUM LEVELS LEVELS AS AS THE THE EFFECT
EFFECT
OF OF SULFONUREA SULFONUREA THERAPY.
THERAPY.
Dworacka Dworacka M. M. 1 2 2 2 2 2 2
, , Abramczyk Abramczyk M. M. , , WW
Winiarska W Winiarska
iniarska H. H. , , K KKuczynski
K uczynski S. S. , , Borowska Borowska M. M. , , Szczawinska Szczawinska K. K. , , W WWierusz
WW
ierusz Wysocka Wysocka B. B.
1 Poznan University of Medical Sciences, Poznan, Poland
2 Poznan University of Medical Sciences, Pharmacology, Poznan, Poland
253. 253. FENOFIBRATE FENOFIBRATE AND AND AND ATORVASTATIN ATORVASTATIN DECREASE DECREASE MONOCYTE MONOCYTE CHEMOTACTIC CHEMOTACTIC PROTEIN PROTEIN 1
1
(MCP-1) (MCP-1) PLASMA PLASMA LEVELS LEVELS AND AND MONOCYTE MONOCYTE RELEASE RELEASE IN IN DYSLIPIDAEMIC DYSLIPIDAEMIC PATIENTS
PATIENTS
Okopien Okopien B., B., Haberka Haberka M., M., Krysiak Krysiak R., R., £abuzek £abuzek £abuzek K., K., Herman Herman Herman ZS.
ZS.
Medical University of Silesia, Katowice, Poland
254. 254. 254. CARDIOVASCULAR CARDIOVASCULAR DISEASES DISEASES AND AND AND LEAD LEAD POLLUTION POLLUTION DUE DUE DUE TO TO THE THE THE INDUSTRIAL INDUSTRIAL ADVANCES
ADVANCES
Nouri Nouri Mugahii Mugahii SMH., SMH., Bagehr Bagehr Nabavi Nabavi SM.
SM.
Khoramshar University of Marine Sciences, Khoramshar, Iran
255. 255. USE USE OF OF MARGARINE MARGARINE ENRICHED ENRICHED IN IN PHYTOSTEROLS PHYTOSTEROLS PHYTOSTEROLS BY BY PATIENTS PATIENTS AT AT HIGH HIGH HIGH CARDIOVASCULAR CARDIOVASCULAR RISK
RISK
Laforest Laforest L. L. 1 2 1 1
, , , Moulin Moulin P PP.
P . , , , VV
Van VV
an Ganse Ganse E. E. , , , Chretin Chretin S. S.
1 Pharmacoepidemiology Unit, EA3091, Lyon Sud University Hospital, Lyon, France
2 Endocrinology Unit, Lyon Sud University Hospital, Lyon, France
257. 257. THE THE INTERACTION INTERACTION OF OF ASPIRIN ASPIRIN AND AND TICLOPIDINE TICLOPIDINE ON ON HEMATOLOGICAL HEMATOLOGICAL PARAMETERS PARAMETERS PARAMETERS IN IN RATS
RATS
Stanojevic Stanojevic Z., Z., Mitic Mitic R., R., Bukumiric Bukumiric Z.
Z.
Faculty of Medicine, University of Pristina, Kosovska Mitrovica, Kosovska Mitrovica, Yugoslavia
258. 258. DOES DOES SIMVASTATIN SIMVASTATIN INFLUENCE INFLUENCE ON ON LIPOLYTIC LIPOLYTIC ACTIVITY ACTIVITY IN IN SERUM SERUM OF OF OF PATIENTS PATIENTS WITH
WITH
CORONARY CORONARY HEART HEART DISEASE?
DISEASE?
Piorunska Piorunska - - Mikolajczak Mikolajczak A AA.,
A A.,
., Mikolajczak Mikolajczak PL, PL, Piorunska Piorunska - - Stolzmann Stolzmann M., M., Iskra Iskra M., M., Strzyzewski Strzyzewski K., K., Majewski Majewski W WW.
W
Poznan University of Medical Sciences, Department of General Chemistry, Poznan, Poland
259. 259. EZETIMIBE EZETIMIBE AND AND EZETIMIBE EZETIMIBE GLUCURONIDE GLUCURONIDE ARE ARE ARE SUBSTRATES SUBSTRATES OF OF THE THE MULTIDRUG MULTIDRUG TRANSPORTER
TRANSPORTER
PROTEINS PROTEINS P-GLYCOPROTEIN P-GLYCOPROTEIN AND AND MRP2
MRP2
Oswald Oswald S. S. 1 1 1 2 1 1 1
, , W WWestrup
W Westrup
estrup S. S. S. , , Adam Adam U. U. , , Jedlitschky Jedlitschky Jedlitschky G. G. G. , , Kroemer Kroemer Kroemer HK HK , , W WWeitschies
W Weitschies
eitschies WW
W. W , , Siegmund Siegmund WW
W. W
1 University of Greifswald, Department of Clinical Pharmacology, Greifswald, Germany
2 University of Greifswald, Department of Pharmacology, Greifswald, Germany
260. 260. AMELIORATION AMELIORATION OF OF RAT RAT RENAL RENAL ISCHEMIA-REPERFUSION ISCHEMIA-REPERFUSION INJURY INJURY BY BY A A SOD-MIMETIC
SOD-MIMETIC
Kadkhodaee Kadkhodaee M., M., Zahmatkesh Zahmatkesh M., M., Ghaznavi Ghaznavi R. R.
R.
Tehran University of Medical Sciences, Physiology, Tehran, Iran
261. 261. ALTERATIONS ALTERATIONS OF OF THE THE NITRIC NITRIC OXIDE OXIDE SYSTEM SYSTEM IN IN CORPUS CORPUS CAVERNOSUM CAVERNOSUM OF OF CHRONIC
CHRONIC
LITHIUM-TREATED LITHIUM-TREATED LITHIUM-TREATED RATS
RATS
Dehghani Dehghani M. M. 1 1 2 1
, , Sadeghipour Sadeghipour H. H. , , , Nobakht Nobakht Nobakht M. M. , , Dehpour Dehpour AR. AR. AR.
1 Tehran University of Medical Sciences, Pharmacology, Tehran
2 Iran University, Histology, Tehran, Iran
– – –

262. 262. 262. IS IS TUMOR TUMOR NECROSIS NECROSIS FACTOR FACTOR FACTOR AN AN IMPORTANT IMPORTANT TARGET TARGET IN IN TREATMENT TREATMENT OF OF OF HEART HEART FAILURE? FAILURE?
FAILURE?
Srdic Srdic D., D., Prostran Prostran M., M., P PPerunicic
P erunicic J. J.
J.
School of Medicine, University of Belgrade, Belgrade, Yugoslavia
POSTER POSTER SESSION SESSION 8
8
263. 263. CLINICAL CLINICAL STUDY STUDY ON ON THE THE THE EFFECT EFFECT OF OF CAVINTON CAVINTON IN IN THE THE TREATMENT TREATMENT OF OF BRAIN BRAIN ISCHAEMIA
ISCHAEMIA
Ilieva Ilieva VV
V. VV
1 2
, , Boyadjieva Boyadjieva N. N.
1 Medical University of Sofa, Sofia, Bulgaria
2 Medical University of Sofa, Basic Pharmacology, Sofia, Bulgaria
267. 267. TREATMENT TREATMENT OF OF NEURODEGENERATIVE NEURODEGENERATIVE DISEASES DISEASES WITH WITH HERBAL HERBAL MEDICINES– MEDICINES– CRITICAL CRITICAL ANALYSIS
ANALYSIS
O¿arowski O¿arowski M., M., Mrozikiewicz Mrozikiewicz PM.
PM.
Research Institute of Medicinal Plants, Poznañ
268. 268. ANTIOXIDANT ANTIOXIDANT DEFENCES DEFENCES AND AND OXIDATIVE OXIDATIVE STRESS STRESS IN IN ELDERLY ELDERLY ALZHEIMER ALZHEIMER PATIENTS
PATIENTS
De De Naranjo Naranjo RS. RS. 1 2 1 1 1 1 1
, , P PParra
P arra A AAT.
A , , , Nicola Nicola R. R. , , Mutis Mutis A AA.
A , , Marquez Marquez M. M. , , Gomez Gomez ME. ME. , , Munoz Munoz Munoz M. M.
1 University of Carabobo, Valencia, Venezuela“2 University of Carabobo, Pharmacology, Valencia, Venezuela
269. 269. DRUG DRUG INTERACTIONS INTERACTIONS BETWEEN BETWEEN BETWEEN LAMOTRIGINE LAMOTRIGINE AND AND PSYCHOACTIVE PSYCHOACTIVE DRUGS: DRUGS: EVIDENCE EVIDENCE FROM
FROM
A A THERAPEUTIC THERAPEUTIC DRUG DRUG MONITORING MONITORING SERVICE
SERVICE
Reimers Reimers A AA.
A 1 2 1 3
, , Skogvoll Skogvoll Skogvoll E. E. , , K KKutschera
K utschera Sund Sund J. J. , , Spigset Spigset O OO.
O
1 St. Olav University Hospital, Department of Clinical Pharmacology, Trondheim, Norway
2 Norwegian University of Science and Technology, Unit for Applied Clinical Research, Faculty of Medicine,
Trondheim, Norway
3 St. Olav University Hospital, Trondheim, Norway
270. 270. THE THE EFFECT EFFECT OF OF SOME SOME CENTRAL CENTRAL ACTIVE ACTIVE SEROTONERGIC SEROTONERGIC AGONISTS AGONISTS AND AND ANTAGONISTS
ANTAGONISTS
ON ON THE THE THE SOMATOSENSORY SOMATOSENSORY EVOKED EVOKED RESPONSES RESPONSES IN IN URETHANE URETHANE ANAESTHETIZED ANAESTHETIZED RAT
RAT
Alaei Alaei F FF.
F
Hospital, Isfahan, Iran
271. 271. EFFECTS EFFECTS OF OF TAMOXIFEN TAMOXIFEN ON ON MORPHOLOGICAL MORPHOLOGICAL MORPHOLOGICAL AND AND ULTRASTRUCTURAL ULTRASTRUCTURAL ULTRASTRUCTURAL ASPECTS ASPECTS
ASPECTS
IN IN IN THE THE DEVELOPING DEVELOPING HIPPOCAMPUS HIPPOCAMPUS OF OF OF RAT
RAT
Nobakht Nobakht M., M., M., Najafzadeh Najafzadeh N., N., Jameie Jameie B. B.
B.
Iran University, Anatomy and Histology, Tehran, Iran
273. 273. NEUROHUMORAL NEUROHUMORAL CONTROL CONTROL OF OF OBESITY
OBESITY
Zayachkivska Zayachkivska O OO.
O
Lviv National Medical University, Lviv, Ukraine
POSTER POSTER SESSION SESSION 9
9
275. 275. 275. INCREASE INCREASE BODY BODY MASS MASS IN IN IN PREGNANT PREGNANT WOMEN WOMEN IN IN CONNECTION CONNECTION WITH WITH TRP64ARG TRP64ARG TRP64ARG POLYMORPHISM
POLYMORPHISM
POLYMORPHISM
Drews Drews Drews K. K. 1 1 1 2
, , Seremak-Mrozikiewicz Seremak-Mrozikiewicz Seremak-Mrozikiewicz A AA.
A , , K KKurzawiñska
KK
urzawiñska G. G. G. , , Nowocieñ Nowocieñ G. G. G.
1 Poznan University of Medical Sciences, Department of Perinatology and Gynecology, Division of Perinatology
and Women's Diseases, Poznan, Poland
2 F. Raszeja Municipal Hospital, Department of Anaestesiology and Intensive Therapy, Poznan, Poland
277. 277. ACUTE ACUTE EFFECTS EFFECTS OF OF ROSIGLITAZONE ROSIGLITAZONE ON ON INSULIN INSULIN PARAMETERS PARAMETERS IN IN HEALTHY HEALTHY VOLUNTEERS
VOLUNTEERS
Farret arret AA
A., A ., Chevassus Chevassus H., H., Roux Roux B. B. , , , P PPetit
P etit P PP.,
P ., Galtier Galtier F FF.
F
1 University Hospital and INSERM CIC 0001, Montpellier, France
278. 278. CAFFEIC CAFFEIC ACID ACID IMPROVES IMPROVES IMPROVES LIPID LIPID METABOLISM METABOLISM METABOLISM IN IN RATS
RATS
Tyszka-Czochara yszka-Czochara M., M., W WWójcik
W Wójcik
ójcik J., J., J., Surmacz Surmacz B., B., Jaœkiewicz Jaœkiewicz J.
J.
Jagiellonian University, Collegium Medicum Department of Analitycal Biochemistry, Kraków, Poland
– – –

279. 279. 279. COLESTILAN COLESTILAN (COLESTIMIDE) (COLESTIMIDE) CAN CAN BE BE BE USED USED AS AS A A PHOSPHATE PHOSPHATE PHOSPHATE BINDER
BINDER
Furuie uruie H. H. 1 1 1 1 2 2 2 1
, , Murakami Murakami Murakami M. M. , , , Matsuguma Matsuguma Matsuguma K. K. K. , , Kanda Kanda Kanda M. M. M. , , Matsuoka Matsuoka T TT.
TT
. , , Matsuura Matsuura Matsuura M. M. , , Nakajima Nakajima S. S. S. , , Irie Irie Irie S. S. S.
1 Medical Co.LTA, Fukuoka, Japan
2 Mitsubishi Pharma Corporation, Osaka, Japan
280. 280. EFFECT EFFECT EFFECT OF OF VITAMIN VITAMIN E E ON ON THE THE MORPHOLOGIC MORPHOLOGIC CHANGES CHANGES OF OF SMALL SMALL INTESTINE INTESTINE IN IN DIABETIC DIABETIC RATS.
RATS.
Shirpoor Shirpoor A AA.
A
Faculty of medicine, Urmia, Iran
POSTER POSTER SESSION SESSION 10
10
281. 281. TRICYCLIC TRICYCLIC ANTIDEPRESSANT ANTIDEPRESSANT ANTIDEPRESSANT PRESCRIBING PRESCRIBING IN IN SOUTH SOUTH AFRICA AFRICA WITH WITH EMPHASIS
EMPHASIS
ON ON THE THE PRESCRIBED PRESCRIBED DAILY DAILY DAILY DOSE
DOSE
Truter ruter I. I. 1 2
, , V VVan
V an W W KK
Kotze K otze TJ. TJ.
1 Nelson Mandela Metropolitan University, Pharmacy, Port Elizabeth, South Africa
2 Statistician, Independent, Cape Town, South Africa
282. 282. THE THE COMPARISON COMPARISON OF OF ANTIEPILEPTIC ANTIEPILEPTIC DRUGS DRUGS UTILIZATION UTILIZATION IN IN THE THE THE CZECH CZECH CZECH REPUBLIC,
REPUBLIC,
SCANDINAVIAN SCANDINAVIAN COUNTRIES COUNTRIES AND AND AUSTRALIA
AUSTRALIA
Koristkova oristkova B. B. 1 1
, , Grundmann Grundmann M. M.
1 University Hospital and Medico-Social Faculty, Univ. of Ostrava, Clinical Pharmacology, Ostrava, Czech Republic
283. 283. 283. SELF-MEDICATION SELF-MEDICATION WITH WITH ANTIBIOTICS ANTIBIOTICS ANTIBIOTICS AND AND ANTIMALARIALS ANTIMALARIALS AMONG AMONG AMONG UNIVERSITY UNIVERSITY STUDENTS STUDENTS IN IN IN SUDAN
SUDAN
Awad Awad A AA.
A 1 1
, , Ahmed Ahmed Ahmed A AA.2,
A A.2,
.2, Matowe Matowe Matowe L. L.
1 Kuwait University, Kuwait
2 Final Year Medical Student - Ahfad University, Community Medicine, Sudan-Khartoum
286. 286. CONSUMPTION CONSUMPTION OF OF OPIOID OPIOID OPIOID ANALGESICS ANALGESICS IN IN SLOVAKIA SLOVAKIA WITH WITH RESPECT RESPECT RESPECT TO TO RISK RISK ASSESMENT
ASSESMENT
Hudec Hudec R. R. 1 1 1 2 1
, , Tisonova Tisonova Tisonova J. J. , , , Bozekova Bozekova L. L. , , , F FFoltan
F oltan V VV.
V , , , Kriska Kriska M. M.
1 Comenius University, School of Medicine, Bratislava, Slovakia
2 School of Pharmacy, Comenius University, Dept. of Organization and Management of Pharmacy, Bratislava, Slovakia
287. 287. CONSUMPTION CONSUMPTION OF OF ANTI-ASTHMATIC ANTI-ASTHMATIC ANTI-ASTHMATIC DRUGS DRUGS DRUGS IN IN IN YAROSLAVL YAROSLAVL (RUSSIA) (RUSSIA) IN IN IN 1999-2004 1999-2004 YEARS YEARS
YEARS
Palyutin alyutin S. S. 1 1 2
, , Y YYakusevich
YY
akusevich VV
V. V , , , Zilber Zilber Zilber I. I. I.
1 Medical Academy, Clinical Pharmacology, Yaroslavl,Russia
2 Clinical Hospital #2, Respiratory Center, Yaroslavl, Russia
288. 288. CONSUMPTION CONSUMPTION OF OF ANTIMICROBIAL ANTIMICROBIAL DRUGS DRUGS IN IN PULMONOLOGY PULMONOLOGY DEPARTMENT DEPARTMENT IN IN YAROSLAVL YAROSLAVL YAROSLAVL (RUSSIA)
(RUSSIA)
Palyutin alyutin alyutin S. S. 1 1 2
, , Y YYakusevich
YY
akusevich VV
V. V , , Zilber Zilber I. I. I.
1 Medical Academy, Clinical Pharmacology, Yaroslavl, Russia
2 Clinical Hospital #2, Respiratory Center, Yaroslavl, Russia
289. 289. TRENDS TRENDS IN IN CONSUMPTION CONSUMPTION OF OF ANALGESIC ANALGESIC DRUGS DRUGS IN IN CZECH CZECH REPUBLIC REPUBLIC REPUBLIC 1998-2003
1998-2003
Jablonska Jablonska D., D., Sklenar Sklenar Z. Z. 1 1 1
, , Dolezal Dolezal T TT.
T , , Svihovec Svihovec Svihovec J., J., Krsiak Krsiak Krsiak M. M.
Department of Pharmacology, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic
1-Department of Pharmacology, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic
290. 290. USE USE OF OF DRUGS DRUGS AT AT SURGICAL SURGICAL SURGICAL DEPARTMENTS DEPARTMENTS OF OF UNIVERSITY UNIVERSITY TEACHING TEACHING HOSPITAL HOSPITAL HOSPITAL IN IN IN NOVI NOVI NOVI SAD,
SAD,
SERBIA SERBIA AND AND MONTENEGRO
MONTENEGRO
Tomic omic Z. Z. 1 2 2
, , Sabo Sabo A AA.
A , , Jakovljevic Jakovljevic V VV.
V
1 Medical Faculty of Novi Sad, Department of Pharmacology, Toxicology and Clinical Pharmacology, Novi Sad, Yugoslavia
2 Mediacl Faculty of Novi Sad, Department of Pharmacology, Toxicology and Clinical Pharmacology, Novi Sad, Yugoslavia
291. 291. THE THE INFLUENCE INFLUENCE OF OF DISPENSATION DISPENSATION OF OF OF THE THE DRUGS DRUGS ON ON THE THE AMOUNT AMOUNT OF OF THEIR THEIR USAGE USAGE USAGE - - EXAMPLE
EXAMPLE
OF OF CLINICS CLINICS CLINICS OF OF UNIVERSITY UNIVERSITY TEACHING TEACHING HOSPITAL HOSPITAL NOVI NOVI NOVI SAD, SAD, SAD, SERBIA SERBIA AND AND MONTENEGRO
MONTENEGRO
MONTENEGRO
Sabo Sabo A AA.,
A ., T TTomic
T omic Z., Z., Z., Jakovljevic Jakovljevic Jakovljevic V VV.
V
Medical Faculty of Novi Sad, Department of Pharmacology, Toxicology and Clinical Pharmacology, Novi Sad, Yugoslavia
– – –

292. 292. 292. DID DID REFORM REFORM STRATEGY STRATEGY OF OF DRUG DRUG MARKET MARKET IMPROVE IMPROVE THE THE OUTPATIENT OUTPATIENT USE USE OF OF OF CARDIOVASCULAR
CARDIOVASCULAR
DRUGS DRUGS IN IN MONTENEGRO MONTENEGRO DURING DURING FOUR-YEARS FOUR-YEARS FOUR-YEARS PERIOD
PERIOD
Duborija-K Duborija-K Duborija-Kovacevic Duborija-K Duborija-K ovacevic N. N. 1 2 , , T TTomic
TT
omic Z. Z. Z.
1 Medical faculty of The University of Montenegro, Podgorica, Yugoslavia
2 Mediacl Faculty of Novi Sad, Pharmacology, Clinical pharmacology and toxicology, Novi Sad, Yugoslavia
293. 293. INPATIENT INPATIENT DRUG DRUG UTILIZATION UTILIZATION AT AT FOUR FOUR SURGERY SURGERY CLINICS CLINICS IN IN IN MONTENEGRO
MONTENEGRO
Goranovic Goranovic S. S. 1 1
, , Duborija-K Duborija-Kovacevic Duborija-K ovacevic N. N.
1 Medical Faculty of The University of Montenegro, Podgorica, Yugoslavia
294. 294. THE THE USE USE OF OF STATINS STATINS IN IN PATIENTS PATIENTS PATIENTS WITH WITH MYOCARDIAL MYOCARDIAL INFARCTION INFARCTION IN IN ESTONIA
ESTONIA
Marandi Marandi T TT.
T 1 2 2 3
, , Ainla Ainla T TT.
T , , , Kampus Kampus P PP.
P , , , Mathiesen Mathiesen M. M.
1 North Estonia Regional Hospital, Tallinn, Estonia
2 Tartu University, Cardiology, Tartu, Estonia
3 Estonian Health Insurance Fund, Tallinn, Estonia
295. 295. SERUM SERUM LIPID-MODIFYING LIPID-MODIFYING LIPID-MODIFYING AGENTS: AGENTS: A A PRESCRIPTION PRESCRIPTION DATABASE DATABASE STUDY
STUDY
Truter ruter I. I. 1 2 , , , Marsh Marsh S. S.
1 Nelson Mandela Metropolitan University, Port Elizabeth, South Africa
2 Researcher, Independent, London, UK
297. 297. DRUG DRUG UTILIZATION UTILIZATION STUDY STUDY STUDY IN IN NEUROLOGICAL NEUROLOGICAL AMBULATORY AMBULATORY PATIENTS.
PATIENTS.
Vaque aque Cabanas Cabanas A AA.
A 1 1 1 1 1 1 1 1 1
, , P PPerez
P erez De De La La La Ossa Ossa N. N. , , Borras Borras A AA.
A , , Soler Soler A AA.
A , , Lopez Lopez N. N. , , Isern Isern I. I. , , TT
Torres T orres F FF.
F , , Costa Costa J. J. , , Ramo Ramo C. C.
1 Hospital, Clinical Pharmacology, Badalona, Spain
298. 298. 298. HOSPITAL HOSPITAL ANALYSIS ANALYSIS OF OF THE THE THE CENTRAL CENTRAL CENTRAL NERVOUS NERVOUS SYSTEM SYSTEM DRUG DRUG UTILIZATION UTILIZATION DURING DURING TWO TWO PERIODS
PERIODS
Vitezic Vitezic D. D. D. 1 2 2 1 1 1
, , , Rosovic- Rosovic- Rosovic- Bazijanac Bazijanac Bazijanac V VV.
V , , , Loncar Loncar A AA.
A , , , Mrsic- Mrsic- Mrsic- P PPelcic
P elcic J. J. , , , Zupan Zupan Zupan G. G. G. , , , Simonic Simonic Simonic A AA.
A
1 University of Rijeka Medical School, Rijeka, Croatia
2 University Hospital Centre Rijeka, Rijeka, Croatia
300. 300. UTILIZATION UTILIZATION STUDY STUDY OF OF RESTRICTED RESTRICTED PRESCRIPTION PRESCRIPTION ANTIBIOTICS
ANTIBIOTICS
Colmenares Colmenares Lopez Lopez FI., FI., T TTerleira
T erleira A AA.,
A A.,
., Sampedro Sampedro A AA.,
A A.,
., P PPortoles
P ortoles AA
A. AA
Clinical Pharmacology Department, Hospital Clínico San Carlos, Spain
301. 301. 5-YEARS 5-YEARS CONSULTATIONS CONSULTATIONS ABOUT ABOUT SAFE SAFE SAFE DRUGS DRUGS USEING USEING IN IN PREGNANCY PREGNANCY AND AND LACTATION
LACTATION
Magulova Magulova L. L. 1 1 1 1 1 1
, , , Sirotiakova Sirotiakova J. J. , , Goboova Goboova M. M. , , Magova Magova Magova M. M. , , Piesecka Piesecka L. L. , , , Zak Zak VV
V. V
1 Teaching Hospital Nitra, Dpt.of Clinical Pharmacology, Nitra, Slovakia
302. 302. THE THE CONCEPT CONCEPT OF OF DEFINED DEFINED DAILY DAILY DOSE DOSE DOSE USED USED FOR FOR MEASUREMENT MEASUREMENT OF OF TOTAL TOTAL TOTAL DRUG DRUG LOAD
LOAD
IN IN PSYCHIATRIC PSYCHIATRIC PATIENTS
PATIENTS
Divac Divac N., N., Bajcetic Bajcetic M., M., Jasovic Jasovic Gasic Gasic M., M., M., Samardzic Samardzic R.
R.
1 School of Medicine, University of Belgrade, Dept. of Pharmacology, Clinical Pharmacology and Toxicology,
Belgrade, Yugoslavia
303. 303. 303. CHANGES CHANGES CHANGES IN IN IN PRESCRIBING PRESCRIBING PRESCRIBING PATTERNS PATTERNS PATTERNS OF OF OF TRICYCLIC TRICYCLIC TRICYCLIC ANTIDEPRESSANTS ANTIDEPRESSANTS ANTIDEPRESSANTS IN IN IN AN AN AN ELDERLY ELDERLY ELDERLY SOUTH SOUTH
SOUTH
AFRICAN AFRICAN POPULATION
POPULATION
Bellingan Bellingan M. M. M. 1 1 1 1
, , , W WWiseman
W iseman I. I. I. , , T TTruter
T Truter
ruter I. I. I. , , V VVenter
VV
enter D. D. D.
1 Nelson Mandela Metropolitan University, Pharmacy, Port Elizabeth, South Africa
304. 304. 304. UNLICENSED UNLICENSED AND AND OFF OFF LABEL LABEL SEDATIVES SEDATIVES SEDATIVES PRESCRIPTION PRESCRIPTION IN IN IN THE THE CARDIOLOGY CARDIOLOGY AND AND CARDIO CARDIO
CARDIO
SURGERY SURGERY PEDIATRIC PEDIATRIC PEDIATRIC CARE CARE UNITS.
UNITS.
Bajcetic Bajcetic M., M., Divac Divac N., N., Samardzic Samardzic R., R., Simeunovic Simeunovic S.
S.
School of Medicine, University of Belgrade, Department of clinical pharmacology, Belgrade, Yugoslavia
305. 305. QUALITY QUALITY OF OF DRUG DRUG UTILIZATION: UTILIZATION: VISUALISING VISUALISING VISUALISING ANTI-BACTERIAL ANTI-BACTERIAL RESISTANCE RESISTANCE BY BY USE USE USE OF OF OF DRUG
DRUG
UTILIZATION UTILIZATION UTILIZATION 90% 90% PROFILES PROFILES PROFILES - - AN AN AN EXAMPLE EXAMPLE FROM FROM ST ST ST PETERSBURG
PETERSBURG
Goryachkina Goryachkina K. K. K. 1 1 1 2
, , Babak Babak Babak S. S. , , Burbello Burbello Burbello A AA.
A , , Bergman Bergman U. U. U.
1 St Petersburg State Medical academy named after Mechnikov, St Petersburg, Russia
2 Laboratory medicine, Karolinska Institutet, Clinical pharmacology, Stockholm, Sweden
– – –

306. 306. 306. EFFECTIVENESS EFFECTIVENESS OF OF DRUG DRUG FORMULARY FORMULARY SYSTEM SYSTEM FOR FOR RATIONALIZATION RATIONALIZATION RATIONALIZATION OF OF OF PHARMACEUTICALS
PHARMACEUTICALS
UTILIZATION UTILIZATION UTILIZATION IN IN IN THE THE SETTING SETTING OF OF BELARUSSIAN BELARUSSIAN MULTIPROFILE MULTIPROFILE HOSPITAL
HOSPITAL
Mily Mily Mily M. M. 1 2 3
, , Lugovoy Lugovoy Lugovoy V VV.
VV
, , Golubev Golubev Golubev S. S.
1 State Medical University, Vitebsk, Ukraine
2 Vitebsk City Emergency Hospital, Vitebsk, Ukraine
3 Vitebsk Regional Clinical Hospital, Vitebsk, Ukraine
307. 307. 10-YEAR 10-YEAR TRENDS TRENDS IN IN IN DRUG DRUG UTILISATION UTILISATION - - ESTONIA ESTONIA ESTONIA AND AND THE THE NORDIC NORDIC NORDIC COUNTRIES
COUNTRIES
Rootslane Rootslane Rootslane L. L. 1 2 2
, , Irs Irs A AA.
A , , Kiivet Kiivet RA RA. RA
1 State Agency of Medicines, Tartu, Estonia
2 Tartu University, Divison of Clinical Pharmacology, Tartu, Estonia
308. 308. USE USE OF OF WHOS WHOS ESSENTIAL ESSENTIAL DRUGS DRUGS DRUGS IN IN IN CROATIA CROATIA AND AND SWEDEN
SWEDEN
B. B. W WWettermark
W ettermark 1 2 1
, , V VV.
V . Vlahovic Vlahovic - - P PPalcevski
P alcevski , , U. U. Bergman Bergman
1 Karolinska Institutet, Department of Clinical Pharmacology, Stockholm, Sweden
2 University Hospital Centre Rijeka, Unit for Clinical Pharmacology, Rijeka, Croatia
309. 309. CARDIOVASCULAR CARDIOVASCULAR DRUG DRUG UTILIZATION UTILIZATION IN IN NIS NIS REGION
REGION
R. R. R. V VVelickovic
V Velickovic
elickovic - - Radovanovic Radovanovic1
1 1 2
, , R. R. Lilic Lilic , , J. J. P PPetrovic
P etrovic , , B. B. K KKodela
K odela 1 Institute of nephrology & haemodialysis, Nis, Yugoslavia
2 Pharmaceutical Institution Nis, Nis, Yugoslavia
POSTER POSTER SESSION SESSION SESSION 11
11
310. 310. POTENTIAL POTENTIAL DRUG-DRUG DRUG-DRUG INTERACTIONS INTERACTIONS INTERACTIONS AMONG AMONG RECENTLY RECENTLY HOSPITALISED HOSPITALISED PATIENTS
PATIENTS
Glintborg Glintborg B. B. 1 2 1
, , , Andersen Andersen Andersen SE. SE. , , , Dalhoff Dalhoff K. K.
1 Rigshospitalet, Copenhagen, Denmark
2 Bispebjerg Hospital, Unit of Clinical Pharmacology, Copenhagen, Denmark
311. 311. OPTIMIZING OPTIMIZING LITHIUM LITHIUM LITHIUM DOSING DOSING IN IN HAEMODIALYSIS
HAEMODIALYSIS
HAEMODIALYSIS
Bjarnason Bjarnason N. N. 1 1 1 2 1
1, 1, 1, Munkner Munkner R. R. R. , , , Ladefoged Ladefoged S. S. , , , TT
Tornoe T ornoe C. C. , , , Dalhoff Dalhoff K. K.
1 Rigshospitalet, Copenhagen, Denmark
2 Ferring Pharmaceuticals A/S, Dept. Clin. Pharmacol., Copenhagen, Denmark
312. 312. THE THE CLINICAL CLINICAL CLINICAL PHARMACOLOGIST PHARMACOLOGIST AND AND COUNSELING COUNSELING COUNSELING OF OF THE THE WOMEN WOMEN ABOUT ABOUT DRUG DRUG USE USE USE IN IN IN PREGNANCY
PREGNANCY
Milovanovic Milovanovic DR., DR., Ruzic Ruzic Ruzic Zecevic Zecevic D., D., Djuric Djuric D., D., Jankovic Jankovic Jankovic S.
S.
Clinical Hospital Center, Kragujevac, Yugoslavia
313. 313. ETIOLOGY ETIOLOGY OF OF BACTERIAL BACTERIAL PURULENT PURULENT MENINOGENCEPHALITIS MENINOGENCEPHALITIS AND AND ANTIMICROBIAL ANTIMICROBIAL SENSITIVITY
SENSITIVITY
SENSITIVITY
CAUSATIVE CAUSATIVE AGENTS
AGENTS
Dupanovic Dupanovic B. B. 1 1 1 1 2 3
, , Andric Andric B. B. , , T TTerzic
T erzic D. D. , , P PPejakov
PP
ejakov L. L. , , T TTomic
T omic Z. Z. , , , Sabo Sabo A AA.
A
1 Medical Faculty of The University of Montenegro, Clinic for Infective Disease, Podgorica, Yougoslavia
2 Faculty of Medicine, Department of Pharmacology, Toxicology and Clinical Pharmacology, Novi Sad, Yougoslavia
3 Faculty of Medicine, Department of Pharmacology, Toxicology and Clinical Pharmacology, Novi Sad, Yougoslavia
314. 314. GENDER-RELATED GENDER-RELATED DIFFERENCES DIFFERENCES IN IN IN LORMETAZEPAM LORMETAZEPAM DISPOSITION DISPOSITION IN IN YOUNG YOUNG YOUNG HEALTHY HEALTHY VOLUNTEERS
VOLUNTEERS
Ochoa Ochoa D. D. 1 1 1 1 1 2 1
, , , Llanos Llanos L. L. , , Laosa Laosa O OO.
O , , E E Ramirez. Ramirez. , , Duque Duque B. B. , , Mesonero Mesonero E. E. , , P P P Guerra. Guerra.
1 La Paz Hospital/ Autonoma University of Madrid, Madrid, Spain
2 Normon Labotarories, Normon Laboratories, Madrid, Spain
315. 315. METOCLOPRAMIDE METOCLOPRAMIDE HAS HAS MODULATORY MODULATORY EFFECTS EFFECTS ON ON HUMAN HUMAN PLASMA PLASMA ADRENOCORTICOTROPIC
ADRENOCORTICOTROPIC
HORMONE HORMONE AND AND CORTISOL CORTISOL LEVELS LEVELS WITH WITH CONTINUAL CONTINUAL STRESS STRESS EXPOSURE
EXPOSURE
Katagiri Katagiri F FF.
F 1 1 1 1 1 1
, , Shiga Shiga TT
T. T , , Inoue Inoue S. S. , , Sato Sato Y YY.
Y , , Itoh Itoh H. H. , , T TTakeyama
T akeyama M. M.
1 Oita University Hospital, Department of Clinical Pharmacy, Oita, Japan
317. 317. PHARMACOKINETICS, PHARMACOKINETICS, INTERACTION INTERACTION AND AND INDIVIDUALIZATION INDIVIDUALIZATION OF OF OF ANTIEPILEPTIC ANTIEPILEPTIC THERAPY THERAPY WITH
WITH
PHENYTOIN PHENYTOIN AND AND AND PHENOBARBITAL PHENOBARBITAL IN IN IN CHILDREN
CHILDREN
Popoviæ opoviæ J.
J.
Medical Faculty of Novi Sad, Novi Sad, Yougoslavia
– – –

318. 318. PHARMACOKINETICS PHARMACOKINETICS (PK) (PK) OF OF TIGECYCLINE TIGECYCLINE (TGC) (TGC) IN IN PATIENTS PATIENTS WITH WITH HEPATIC HEPATIC IMPAIRMENT
IMPAIRMENT
IMPAIRMENT
Baird-Bellaire Baird-Bellaire S.J. S.J. 1 1 2 3 3 4
, , P PPatat
P atat A AA.A
A .A .A. .A , , T TTroy
T roy S.M. S.M. , , , Böhmer Böhmer G. G. , , Gleiter Gleiter C. C. , , Morgan Morgan M. M. M.
1 Wyeth Research, Phase 1 Clinical Pharmacology, Paris - La Défense, France
2 Incyte Corporation, Wilmington, Delaware, USA
3 Abteilung Klinische Pharmakologie, FÄ Innere Medizin, Tübingen, Germany
4 Royal Free Hospital, London, UK
319. 319. POSTOPERATIVE POSTOPERATIVE ANALGESIA ANALGESIA AND AND AND OXYGEN OXYGEN TISSUE TISSUE SATURATION SATURATION IN IN CHILDREN
CHILDREN
Pejakov ejakov L. L. 1 2 2 3
, , Sabo Sabo A AA.
A , , T TTomic
T omic Z. Z. , , Dupanovic Dupanovic B. B.
1 Medical Faculty of The University of Montenegro, Clinic of anaesthesia, intensive care and pain therapy,
Podgorica, Yougoslavia
2 Medical Faculty of Novi Sad, Pharmacology and Toxicology, Novi Sad, Yougoslavia
3 Medical faculty of The University of Montenegro, Clinic of Infectious diseases, Podgorica, Yougoslavia
320. 320. THE THE SLOVAK SLOVAK DRUG DRUG DRUG INFORMATION INFORMATION CENTER CENTER DURING DURING THE THE PERIOD PERIOD 1997-2004
1997-2004
Kriska Kriska M., M., M., W WWawruch
W awruch M., M., Bozekova Bozekova L., L., Raganova Raganova A AA.,
A ., Lassanova Lassanova M., M., Hudec Hudec R., R., R., Tisonova Tisonova J., J., V VVojtko
V ojtko R.
R.
Comenius University, School of Medicine, Bratislava, Slovakia
321. 321. A A CRITICAL CRITICAL REVIEW REVIEW OF OF GUIDELINES GUIDELINES FOR FOR LOW LOW BACK BACK PAIN PAIN TREATMENT
TREATMENT
Arnau Arnau J. J. M. M. 1 1 1 2 3 4
, , V VVallano
V allano A AA.
A , , Lopez Lopez A AA.
A , , PP
Pellisé P Pellisé
ellisé F FF.
F , , Delgado Delgado M. M. J. J. , , Prat Prat N. N. N.
1 Hospital Universitari Vall d'Hebron, Servei de Farmacologia Clínica - Fundació Institut Catala de Farmacologia,
Barcelona, Spain
2 Hospital Universitari Vall d'Hebron, Servei de Traumatologia i Ortopedia, Barcelona, Spain
3 DAP Sant Andreu, Servei de Rehabilitació, Barcelona, Spain
4 ABS Montornés-Montmelo, Barcelona, Spain
322. 322. AUDIT AUDIT OF OF THE THE USE USE OF OF OF NEW NEW MEDICATION MEDICATION CHARTS CHARTS INTRODUCED INTRODUCED AT AT AT A A PSYCHIATRIC PSYCHIATRIC PSYCHIATRIC DEPARTMENT
DEPARTMENT
IN IN DENMARK
DENMARK
DENMARK
Sorensen Sorensen L., L., Damkier Damkier PP
P. PP
Odense University Hospital, Clinical Pharmacology, Odense, Denmark
323. 323. EFFECTS EFFECTS OF OF OF EXENATIDE EXENATIDE ON ON LISINOPRIL LISINOPRIL PHARMACOKINETICS PHARMACOKINETICS AND AND PHARMACODYNAMICS
PHARMACODYNAMICS
IN IN IN PATIENTS PATIENTS TREATED TREATED TREATED FOR FOR HYPERTENSION
HYPERTENSION
Linnenbjerg Linnenbjerg H. H. 1 2 2 1 2 1
, , K KKothare
K othare P PP.
P , , , P PPark
P ark S. S. S. , , Atkins Atkins M. M. , , Mace Mace K. K. , , , Mitchell Mitchell Mitchell M. M.
1 Eli Lilly and Company, Windlesham, UK
2 Eli Lilly and Company, Indianapolis, Indiana, USA
324. 324. USE USE OF OF WEIGTH WEIGTH OR OR BODY BODY SURFACE SURFACE FOR FOR CORRECTION CORRECTION OF OF ADMINISTERED ADMINISTERED DOSE DOSE FOR
FOR
THE THE EVALUATION EVALUATION EVALUATION OF OF OF BETWEEN-SEX BETWEEN-SEX PHARMACOKINETIC PHARMACOKINETIC DIFFERENCES
DIFFERENCES
Ramirez Ramirez Ramirez E. E. 1 2 2 2 2 2 2
, , Lubomirov Lubomirov R. R. , , T TTabares
T abares B. B. , , Ochoa Ochoa Ochoa D. D. , , Llanos Llanos L. L. , , Laosa Laosa O OO.
O , , , FF
Frias F rias J. J.
1 La Paz Hospital/ Autonoma University of Madrid, Madrid, Spain
2 La Paz Hospital/ Autonoma University of Madrid, Clinical Pharmacology, Madrid, Spain
325. 325. EFFECTS EFFECTS OF OF OF EXENATIDE EXENATIDE ON ON DIGOXIN DIGOXIN PHARMACOKINETICS
PHARMACOKINETICS
Mitchell Mitchell Mitchell M. M. 1 2 , , , Linnebjerg Linnebjerg H. H. , , K KKothare
K othare P PP.3,
P P.3,
.3, P PPark
PP
ark S. S. S. , , Mace Mace K. K. K.3, K. K. , Soon Soon D. D. 2 2 2
, , Chan Chan C. C. C. , , W WWise
W ise S. S. S.
1 Eli Lilly and Company, Windlesham, UK
2 Eli Lilly and Company, Windlesham, UK
3 Eli Lilly and Company, Indianapolis, Indiana, USA
326. 326. INADEQUATE INADEQUATE QUALITY QUALITY OF OF CARE CARE IN IN ASTHMA ASTHMA PATIENTS: PATIENTS: STUDY STUDY IN IN COMMUNITY COMMUNITY COMMUNITY PHARMACIES
PHARMACIES
Van an Ganse Ganse E. E. E. 2 2 2 2 3 2 3
, , , Laforest Laforest Laforest L. L. , , Devouassoux Devouassoux Devouassoux G. G. , , , Chretin Chretin S. S. , , , Bauguil Bauguil G. G. , , , P PPacheco
PP
acheco YY
Y. YY
, , , Chamba Chamba G. G.
1 Pharmacoepidemiology Unit, EA3091, Lyon Sud University Hospital, Lyon, France
2 Respiratory Medicine, EA3091, Lyon Sud University Hospital, Lyon, France
3 Faculty of Pharmacy, Claude-Bernard University, Lyon, France
328. 328. CLINICAL CLINICAL CLINICAL APPRECIATION APPRECIATION OF OF THE THE THE SERVICES SERVICES SERVICES PROVIDED PROVIDED BY BY BY THE THE DRUG DRUG DRUG INFORMATION INFORMATION CENTRE
CENTRE
AT AT KAROLINSKA KAROLINSKA UNIVERSITY UNIVERSITY HOSPITAL.
HOSPITAL.
Böttiger Böttiger Y YY.,
Y ., Brodén Brodén M. M.
M.
Laboratory medicine, Karolinska Institutet, Stockholm, Sweden
– – –

330. 330. 330. CONTINUOUS CONTINUOUS VERSUS VERSUS INTERMITTENT INTERMITTENT DOSAGE DOSAGE REGIMENS REGIMENS OF OF OF BETA-LACTAM BETA-LACTAM ANTIBIOTICS ANTIBIOTICS - -
-
PREDICTION PREDICTION OF OF ANTIBACTERIAL ANTIBACTERIAL EFFECT
EFFECT
Sedivy Sedivy J. J. 1 2 3 4 4
, , P PPetkov
P etkov VV
V. V , , Jirkovska Jirkovska AA
A. AA
, , Stambergova Stambergova AA
A. AA
, , Ulbrichova Ulbrichova Z. Z.
1 Institute for Clinical and Exper. Medicine, Prague, Czech Republic
2 Institute for Clinical and Exper. Medicine, Dept. Clin. Microbiology, Prague, Czech Republic
3 Institute for Clinical and Exper. Medicine, Diabetes Centre, Prague, Czech Republic
4 Institute for Clinical and Exper. Medicine, Dept. Clin. Pharmacology, Prague, Czech Republic
331. 331. CONTRIBUTORS CONTRIBUTORS TO TO THE THE THE VARIABILITY VARIABILITY IN IN AMIKACIN AMIKACIN CLEARANCE CLEARANCE IN IN PRETERM PRETERM PRETERM NEONATES
NEONATES
Allegaert Allegaert K. K. 1 2 3 3 4
, , Anderson Anderson B. B. , , Cossey Cossey V VV.
V , , VV
Vanhole V Vanhole
anhole C. C. , , Holford Holford N. N.
1 University Hospital, Gasthuisberg, Leuven, Belgium
2 University of Auckland, New Zealand, Anesthesiology, Auckland
3 University Hospital, Gasthuisberg, Neonatal Intensive Care Unit, Leuven, Belgium
4 University of Auckland, Department of Pharmacology & Clinical Pharmacology, Auckland
332. 332. EFFECT EFFECT OF OF CHOLINE CHOLINE DEFICIENT DEFICIENT DIET DIET ON ON HEPATIC HEPATIC METABOLISM
METABOLISM
Liapi Liapi Liapi C. C. 1 1 1 1 2
, , Segos Segos D. D. , , Rapti Rapti H. H. , , Galanopoulou-K
Galanopoulou-Kouvari Galanopoulou-K ouvari P PP.
P , , K KKonstandi
K onstandi M. M.
1 University of Athens, Department of Pharmacology, Medical School, Athens, Greece
2 University of Athens, Department of Pharmacology, Medical School of Ioannina, Athens, Greece
333. 333. HAS HAS TOPIRAMATE TOPIRAMATE ADVANTAGES ADVANTAGES ADVANTAGES IN IN MIGRAINE MIGRAINE MIGRAINE PROPHYLAXIS?
PROPHYLAXIS?
Ergun Ergun H. H. 1 2 1
, , Gulmez Gulmez SE. SE. , , T TTulunay
T ulunay C. C.
1 Medical School of Ankara University, Department of Pharmacology & Clinical Pharmacology, Ankara, Turkey
2 Medical School of Ankara University, Ankara, Turkey
334. 334. INFLUENCE INFLUENCE OF OF MONTELUKAST MONTELUKAST ON ON THE THE EXERCISE-INDUCED EXERCISE-INDUCED ASTHMA
ASTHMA
Bokonjic Bokonjic D. D. 1 2 3
, , Miric Miric Miric M. M. M. , , , Ristic Ristic S. S. S.
1 Medical faculty University of East Sarajevo, Foca, Bosnia
2 Medical faculty University of East Sarajevo, Pathophysiology, Belgrade, Yugoslavia
3 Faculty of Medicine, Physiology, Sarajevo, Bosnia
335. 335. LACK LACK OF OF A A A CLINICALLY CLINICALLY CLINICALLY RELEVANT RELEVANT INTERACTION INTERACTION BETWEEN BETWEEN BAZEDOXIFENE BAZEDOXIFENE AND AND ATORVASTATIN
ATORVASTATIN
IN IN POSTMENOPAUSAL POSTMENOPAUSAL WOMEN
WOMEN
Bellaire Bellaire S. S. 1 2 1 2 3
, , , Mc Mc K KKeand
K eand W WW.
W , , P PPatat
PP
atat A AA.
A , , , P PParker
P arker V VV.
V , , , Chrétien Chrétien Chrétien P PP.
P
1 Wyeth Parmaceuticals France, Clinical Pharmacology, Paris - La Défense, France
2 Wyeth Research, Clinical Pharmacology, Collegeville, USA.
3 Cémax, Rouen
336. 336. PATIENT PATIENT COUNSELLING COUNSELLING BY BY COMMUNITY COMMUNITY PHARMACISTS PHARMACISTS AT AT DISCHARGE DISCHARGE DISCHARGE FROM FROM THE THE HOSPITAL
HOSPITAL
Hugtenburg Hugtenburg J. J. 1 2 3
, , Beckeringh Beckeringh J.J. J.J. , , De De Jong Jong M. M.
1 VU university medical center, Medical Pharmacology, Amsterdam, Netherlands
2 Association of Community Pharmacists Amsterdam, Association of Comunity Pharmacists Amsterdam, Netherlands
3 Association of Community Pharmacists Amsterdam, Associationf of Community Pharmacists Amsterdam, Netherlands
337. 337. 337. RISK RISK RISK FACTORS FACTORS FACTORS OF OF OF MRSA MRSA MRSA INFECTION INFECTION INFECTION IN IN IN CLINICAL CLINICAL CLINICAL HOSPITAL HOSPITAL HOSPITAL CENTRE CENTRE CENTRE ZAGREB ZAGREB
ZAGREB
Mercep Mercep I., I., Makar Makar Makar-Ausperger Makar -Ausperger K., K., F FFrancetic
F rancetic I., I., Bilusic Bilusic M., M., Macolic-Sarinic Macolic-Sarinic Macolic-Sarinic VV
V., VV
., Erdeljic Erdeljic VV
V. VV
Department of Internal Medicine, Division of Clinical Pharmacology, Clinical Hospital Centre, Zagreb, Croatia
338. 338. TDM TDM OF OF LAMOTRIGINE LAMOTRIGINE IN IN CHILDHOOD
CHILDHOOD
CHILDHOOD
Grundmann Grundmann M. M. 1 1 1 1 1
, , , Kacirova Kacirova Kacirova I. I. , , , KK
Koristkova KK
oristkova B. B. , , Brozmanova Brozmanova H. H. , , KK
Komzakova KK
omzakova I. I.
1 University Hospital and Medico-Social Faculty, Univ. of Ostrava, Dept. Clin. Pharmacol., Ostrava, Czech Republic
339. 339. THE THE EFFECTS EFFECTS OF OF PRETREATMENT PRETREATMENT AND AND POST-TREATMENT POST-TREATMENT ADMINISTRATION ADMINISTRATION OF OF ESOMEPRAZOLE
ESOMEPRAZOLE
ON ON ALCOHOL ALCOHOL INDUCED INDUCED STRESS STRESS ULCER ULCER LESIONS LESIONS IN IN IN RATS
RATS
Bukumiric Bukumiric Z. Z. 1 2 2 3 4
, , Janiæijeviæ Janiæijeviæ Hudomal Hudomal S. S. S. , , , Stevoviæ Stevoviæ Rasiæ Rasiæ J. J. , , , Piperski Piperski V VV.
V , , Stanojeviæ Stanojeviæ Z. Z.
1 Medical Faculty Priština-Kosovska Mitrovica, Kosovska Mitrovica, Yugoslavia
2 Medical Faculty Priatina-Kosovska Mitrovica, Institute of Pharmacology and Toxicology, Kosovska Mitrovica, Yugoslavia
3 A.D. Galenika, Beograd, 2Department for biomedical research, Belgrade, Yugoslavia
4 Medical Faculty Priatina-Kosovska Mitrovica, 1Institute of Pharmacology and Toxicology, Kosovska Mitrovica, Yugoslavia
– – –

340. 340. 340. THE THE THE INFLUENCE INFLUENCE INFLUENCE OF OF COMBINATION COMBINATION COMBINATION BOTH BOTH BOTH INDUCTORS INDUCTORS AND AND INHIBITOR INHIBITOR ON ON LAMOTRIGINE LAMOTRIGINE PLASMA PLASMA
PLASMA
LEVELS LEVELS IN IN IN ADULTS
ADULTS
Grundmann Grundmann M. M. 1 1 1 1 1
, , , K KKoristkova
K oristkova B. B. , , Kacirova Kacirova I. I. , , Brozmanova Brozmanova H. H. H. , , KK
Komzakova K omzakova I. I. I.
1 University Hospital and Medico-Social Faculty, Univ. of Ostrava, Dept. Clin. Pharmacol., Ostrava, Czech Republic
341. 341. UNNECESSARY UNNECESSARY DRUG DRUG USE USE WITH WITH SERIOUS SERIOUS CONSEQUENCES
CONSEQUENCES
Makar Makar-Ausperger Makar -Ausperger K., K., Mercep Mercep I., I., F FFrancetic
FF
rancetic I., I., Bilusic Bilusic M., M., Macolic Macolic Sarinic Sarinic V VV.,
V ., Huic Huic M. M.
M.
Clinical Hospital Centre Zagreb, Devision of clinical pharmacology, Dept. of Medicine, Zagreb, Croatia
342. 342. VANCOMYCIN VANCOMYCIN DOSAGE DOSAGE MAY MAY NEED NEED ADJUSTMENT ADJUSTMENT AFTER AFTER SERUM SERUM LEVEL LEVEL MONITORING MONITORING IN IN SPITE SPITE OF
OF
A A A RIGHT RIGHT PRESCRIPTION
PRESCRIPTION
Pérez Pérez BR. BR. 1 1 1 1 1 1 , , García García Sáiz Sáiz MDM MDM , , Gómez Gómez Gómez Ontanón Ontanón E. E. , , Requena Requena G. G. , , , Aldea Aldea AA
A. AA
, , Rodríguez Rodríguez Rodríguez C. C. 1,
1,
Milena Milena A AA.
A 2 1
, , Boada Boada J.N. J.N.
1 University Hospital, Clinical Pharmacology Service, La Laguna – Tenerife, Spain
2 University Hospital, Laboratory Central, La Laguna – Tenerife, Spain
343. 343. TUMORIGENESIS TUMORIGENESIS CAUSED CAUSED BY BY SUMISCLEX SUMISCLEX AND AND AFALON AFALON S S VIA VIA ENDOCRINE ENDOCRINE ENDOCRINE DISRUPTING DISRUPTING MECHANISM
MECHANISM
Soliman Soliman M.
M.
Faculty of Veterinary Medicine, Cairo University, Giza, Egypt
344. 344. BENEFITS BENEFITS OF OF ANTIBIOTIC ANTIBIOTIC USE USE OPTIMIZATION OPTIMIZATION PROGRAM PROGRAM IN IN THE THE LARGEST LARGEST CROATIAN CROATIAN UNIVERSITY UNIVERSITY HOSPITAL HOSPITAL
HOSPITAL
Likic Likic R., R., F FFrancetic
F rancetic I., I., Bilusic Bilusic M., M., Erdeljic Erdeljic V VV.,
V ., Makar Makar Ausperger Ausperger K., K., Junacko Junacko C.
C.
Clinical Hospital Centre, Internal medicine, Zagreb, Croatia
346. 346. 346. EFFECTS EFFECTS EFFECTS OF OF OF GRAPEFRUIT GRAPEFRUIT JUICE JUICE ON ON THE THE PHARMACOKINETICS PHARMACOKINETICS OF OF OF ACEBUTOLOL
ACEBUTOLOL
Lilja Lilja J.J., J.J., Raaska Raaska K., K., Neuvonen Neuvonen Neuvonen P PP.J.
PP
.J.
University of Helsinki, Department of Clinical Pharmacology, Helsinki, Finland
347. 347. 347. MONITORING MONITORING OF OF UNDESIRABLE UNDESIRABLE EFFECTS EFFECTS EFFECTS OF OF DRUGS DRUGS AS AS A A METHOD METHOD OF OF INCREASING INCREASING SAFETY
SAFETY
IN IN PHARMACOTHERAPY
PHARMACOTHERAPY
Woroñ oroñ J., J., K KKostka
K ostkaostka-Tr¹bkaostka r¹bka E., E., K KKorbut
K orbut R., R., Goszcz Goszcz A AA.
A
Chair of Pharmacology, Jagiellonian University, Kraków, Poland
482. 482. CONSULTING CONSULTING ON ON DRUGS DRUGS IN IN PREGNANCY PREGNANCY – – PREGNANCY PREGNANCY PREGNANCY OUTCOMES
OUTCOMES
Macoliæ Macoliæ Šariniæ Šariniæ VV
V., VV
., Erdeljiæ Erdeljiæ V VV.,
V V.,
., FF
Francetiæ F Francetiæ
rancetiæ I., I., Bilušiæ Bilušiæ M., M., Huiæ Huiæ M., M., Makar Makar-Aušperger Makar -Aušperger K., K., Meræep Meræep I.
I.
Unit of Clinical Pharmacology, Department of Medicine, University Hospital Center Zagreb, Croatia
POSTER POSTER SESSION SESSION SESSION 12
12
349. 349. APOPTOSIS APOPTOSIS OF OF ACTIVATED ACTIVATED MONOCYTES: MONOCYTES: HOW HOW HOW DOES DOES THIS THIS THIS IMPACT IMPACT ON ON THE THE INFLAMMATORY INFLAMMATORY RESPONSE?
RESPONSE?
Ottonello Ottonello L., L., Bertolotto Bertolotto M., M., Montecucco Montecucco F FF.,
F ., Dapino Dapino P PP.,
P P.,
., Dallegri Dallegri F FF.
F
University of Genoa Medical School, First Clinic of Internal Medicine, Department of Internal Medicine, Genoa, Italy
350. 350. 350. ARTROFOON, ARTROFOON, ARTROFOON, ORAL ORAL ORAL ULTRA-LOW ULTRA-LOW ULTRA-LOW DOSES DOSES DOSES OF OF OF ANTIBODIES ANTIBODIES ANTIBODIES TO TO TO TNF-ALPHA, TNF-ALPHA, TNF-ALPHA, IS IS EFFECTIVE EFFECTIVE EFFECTIVE BOTH BOTH
BOTH
IN IN RHEUMATOID RHEUMATOID ARTHRITIS ARTHRITIS AND AND OSTEOARTHRITIS
OSTEOARTHRITIS
OSTEOARTHRITIS
Digina Digina JL. JL. 1 2 2 1 2 2 , , P PPetrov
P etrov VI. VI. , , . . Babayeva Babayeva Babayeva AR AR , , Martyushev Martyushev - - PP
Poklad PP
oklad oklad A AAV.
A , , KK
Kostryukova KK
ostryukova IV IV. IV IV , , T TTcherevkova
T cherevkova EV EV EV. EV , , Kacha- KachaKachanova nova nova MV MV MV. MV MV 1 1 1
, , , Epstein Epstein Epstein OI. OI. , , Sergeeva Sergeeva Sergeeva SA SA. SA
1 Materia Medica Holding Reasearch and Production Company, Moscow, Russia
2 Volgograd State Medical University, Volgograd, Russia
351. 351. THE THE THE EFFICACY EFFICACY OF OF TRAMADOL TRAMADOL IN IN IN PROTECTION PROTECTION PROTECTION OF OF STRESS STRESS ULCER ULCER LESIONS LESIONS IN IN RATS RATS INDUCED
INDUCED
BY BY COLD-RESTRAINT COLD-RESTRAINT MODEL MODEL
MODEL
Stevoviæ Stevoviæ Rasiæ Rasiæ J. J. 1 2 2 3
, , Janiæijeviæ Janiæijeviæ Janiæijeviæ Hudomal Hudomal S. S. , , Bukumiriæ Bukumiriæ Bukumiriæ Z. Z. , , Piperski Piperski VV
V. V
1 Medical Faculty Priština-Kosovska Mitrovica, Belgrade, Yugoslavia
2 Medical Faculty Priština-Kosovska Mitrovica, Institute of Pharmacology and Toxicology, Kosovska Mitrovica Yugoslavia
3 A.D. Galenika, Beograd, Department for biomedical research, Belgrade Yugoslavia
– – –

352. 352. 352. COMPARISON COMPARISON BETWEEN BETWEEN TWO TWO DOSES DOSES OF OF OF CORTICOSTEROID CORTICOSTEROID INJECTED INJECTED INJECTED VIA VIA EPIDURAL EPIDURAL ROUTE ROUTE
ROUTE
IN IN IN LUMBAR LUMBAR LUMBAR RADICULAR RADICULAR PAIN
PAIN
Bagher Bagher O OO.
O 1 2
, , Gholamhosein Gholamhosein AA
A. AA
1 Yazd Sadoughi Medical University, Yazd, Iran
2 Baghiyatollah University, Rheumatology Department, Tehran, Iran
353. 353. COMPARISON COMPARISON OF OF TRAMADOLE TRAMADOLE PHARMACOKINETICS PHARMACOKINETICS AFTER AFTER ORAL ORAL AND AND RECTAL RECTAL ADMINISTRATION
ADMINISTRATION
IN IN HEALTHY HEALTHY VOLUNTEERS
VOLUNTEERS
Kopecky opecky J. J. J. 1 1 2 1 1 1 1
, , Nobilis Nobilis Nobilis M. M. , , P PPerlik
P erlik F FF.
FF
, , , Chladek Chladek J. J. , , Zoulova Zoulova J. J. , , . . Svoboda Svoboda D D , , Kvetina Kvetina Kvetina J. J.
1 Institute of Experimental Biopharmaceutics, Hradec Kralove, Czech Republic
2 Charles University, 1st Faculty of Medicine, Prague, Czech Republic
354. 354. IL-10 IL-10 PROMOTER PROMOTER POLYMORPHISM POLYMORPHISM IN IN IN PATIENTS PATIENTS WITH WITH RHEUMATOID RHEUMATOID ARTHRITIS
ARTHRITIS
Pawlik awlik A AA.
A 1 2 1 2 1 .3 .3
2
, , KK
Kurzawski K Kurzawski
urzawski M. M. , , Czerny Czerny B. B. , , . . Juzyszyn Juzyszyn Z. Z. , , Gawronska-Szklarz Gawronska-Szklarz B. B. , , Herczynska Herczynska M M , , Drozdzik Drozdzik M. M.
1 Pomeranian Medical University, Department of Pharmacokinetics and Therapeutic Drug Monitoring, Szczecin, Poland
2 Pomeranian Medical University, Department of Experimental and Clinical Pharmacology, Szczecin, Poland
3 Country Hospital, Clinical Department of Rheumatology, Szczecin, Poland
355. 355. IL1BETA+3953 IL1BETA+3953 EXON EXON 5 5 AND AND IL-2 IL-2 -330 -330 PROMOTER PROMOTER POLYMORPHISMS POLYMORPHISMS IN IN PATIENTS PATIENTS WITH
WITH
RHEUMATOID RHEUMATOID ARTHRITIS
ARTHRITIS
Pawlik awlik A AA.
A 1 2 1 1 3
, , , K KKurzawski
K urzawski M. M. , , Florczak Florczak M. M. , , Gawronska-Szklarz Gawronska-Szklarz Gawronska-Szklarz B. B. , , Herczynska Herczynska M. M.
1 Pomeranian Medical University, Department of Pharmacokinetics and Therapeutic Drug Monitoring, Szczecin, Poland
2 Pomeranian Medical University, Department of Clinical and Experimental Pharmacology, Szczecin, Poland
3 Pomeranian Medical University, Department of Rheumatology, Szczecin, Poland
356. 356. INFLUENCE INFLUENCE OF OF SYSTEMIC SYSTEMIC LUPUS LUPUS ERYTHEMATOSUS ERYTHEMATOSUS ON ON THE THE PHARMACOKINETICS PHARMACOKINETICS OF OF OF FENOPROFEN
FENOPROFEN
Barissa Barissa G G R. R. 1 2 3 1 1 1
, , Della Della P PPasqua
P asqua OE. OE. , , Donadi Donadi EA EA. EA , , , P PPoggi
P oggi JC. JC. JC. , , , Reis Reis Reis ML. ML. ML. , , , Lanchote Lanchote Lanchote VL. VL.
1 Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Brazil
2 Leiden University, Department of Pharmacology, Leiden, Netherlands
3 Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Brazil
358. 358. 358. NALTREXONE NALTREXONE PHARMACOKINETICS PHARMACOKINETICS PHARMACOKINETICS AND AND EFFICACY EFFICACY IN IN REVERSING REVERSING THE THE EFFECTS EFFECTS EFFECTS OF OF BUPRENORPHINE
BUPRENORPHINE
BUPRENORPHINE
Escher Escher M., M., Chabert Chabert J., J., Daali Daali Daali Y YY.,
Y ., Dayer Dayer P PP.,
P ., Desmeules Desmeules J.
J.
Geneva University Hospitals, Geneva, Switzerland
359. 359. OUR OUR OUR EXPERIENCE EXPERIENCE OF OF INFIXIMAB INFIXIMAB USE USE USE IN IN RHEUMATOID RHEUMATOID ARTHRITIS
ARTHRITIS
Kevra evra M. M. 1 2 2
, , K KKeura
K Keura
eura V VV.
V , , Soroka Soroka N. N.
1 Belarisian State Medical University, Minsk, Belarus
2 Belarisian State Medical University, Internal Medicine Department, Minsk, Belarus
360. 360. PENTOXIFYLLINE PENTOXIFYLLINE IMPROVES IMPROVES DICLOFENAC DICLOFENAC EFFECTIVENESS EFFECTIVENESS AND AND SAFETY SAFETY IN IN RHEUMATOID RHEUMATOID ARTHRITIS
ARTHRITIS
Kevra evra M. M. 1 2 3
, , K KKeuraV
K euraV euraV. euraV , , K KKeura
K eura Z. Z.
1 Belarisian State Medical University, Minsk, Belarus
2 Belarisian State Medical University, Internal Medicine Department, Minsk, Belarus
3 Belarisian State Medical University, Department of Clinical Pharmacology, Minsk, Belarus
361. 361. 361. THE THE PRESENCE PRESENCE OF OF NIMESULIDE NIMESULIDE IN IN SYNOVIAL SYNOVIAL FLUID: FLUID: A A COMPARISON COMPARISON BETWEEN BETWEEN ADMINISTRATION ADMINISTRATION ROUTES
ROUTES
Ergun Ergun H. H. H. 1 2 2 3 4 5
, , , Erdogan Erdogan Erdogan F FF.
F , , Gokay Gokay S. S. , , , Gulmez Gulmez Gulmez SE. SE. , , Bolay Bolay Bolay B. B. , , T TTulunay
T ulunay C. C.
1 Medical School of Ankara University, Pharmacology and Clinical Pharmacology, Ankara, Turkey
2 Istanbul University Cerrahpasa School of Medicine, Department of Orthopedics and Traumatology, Istanbul, Turkey
3 Medical School of Ankara University, Ankara, Turkey
4 Istanbul University Cerrahpasa School of Medicine, Istanbul, Turkey
5 Ankara University School of Medicine, Department of Pharmacology & Clinical Pharmacology, Ankara, Turkey
362. 362. THE THE ROLE ROLE OF OF CHRONIC CHRONIC GLUCOCORTICOID GLUCOCORTICOID ADMINISTRATION ADMINISTRATION ON ON PREVENTING PREVENTING PREVENTING MORPHINE
MORPHINE
MORPHINE
ADDICTION ADDICTION IN IN IN RATS
RATS
Dashti Dashti Rahmatabadi Rahmatabadi MH. MH. MH. 1 2 3 3
, , Rafati Rafati A AA.
A , , Morshedi Morshedi A AA.
A , , Salami Salami AA AA. AA
1 Shahid Sadughi Medical University, Yazd, Iran
2 Shahid Sadughi Medical University, Physiology, Yazd, Iran
3 Shahid Sadughi Medical University, Physiology, Yazd, Iran
– – –

363. 363. 363. TRAMADOL TRAMADOL DISPOSITION: DISPOSITION: IN IN VIVO VIVO CYP2D6 CYP2D6 ONTOGENY ONTOGENY IN IN NEONATES NEONATES NEONATES AND AND CHILDREN
CHILDREN
Allegaert Allegaert K. K. 1 2 2 3 3 4 5
, , De De Hoon Hoon Hoon J. J. J. , , V VVerbesselt
V Verbesselt
erbesselt R. R. R. , , Devlieger Devlieger H. H. , , Rayyan Rayyan M. M. M. , , Tibboel Tibboel Tibboel D. D. D. , , Anderson Anderson Anderson B. B. B.
1 University Hospital, Gasthuisberg, neonatal intensive care unit, Leuven, Belgium
2 University Hospital, Gasthuisberg, Center for Clinical Pharmacology, Leuven, Belgium
3 University Hospital, Gasthuisberg, Neonatal Intensive Care Unit, Leuven, Belgium
4 Erasmus Medical Centre, Paediatric Surgery, Rotterdam, Holland
5 University of Auckland, Anesthesiology, Auckland, New Zealand
365. 365. MEASUREMENT MEASUREMENT OF OF ?-TOCOPHEROL ?-TOCOPHEROL AND AND ?-CAROTENE ?-CAROTENE OF OF SERUM SERUM IN IN THE THE EARLY EARLY DIAGNOSIS
DIAGNOSIS
OF OF RHEUMATOID RHEUMATOID ARTHRITIS ARTHRITIS (IRAN) (IRAN)
(IRAN)
Shokrzadeh Shokrzadeh M. M. 1 2
, , Ebadi Ebadi AG. AG. AG.
1Department of Toxicology and Pharmacology, Mazandaran University of Medical Sciences, Iran
2 Department of Biology, Islamic Azad University of Sari, Sari, Iran
366. 366. INFLUENCE INFLUENCE OF OF THE THE DIET DIET ON ON THE THE BIOAVAILABILITY BIOAVAILABILITY BIOAVAILABILITY OF OF TILIDINE/NALOXONE
TILIDINE/NALOXONE
Bogdanov Bogdanov Bogdanov I. I. 1 2 , , K KKolev
K olev E. E.
1 Medical University of Sofa, Sofia, Bulgaria
2 Medical University of Sofa, Department of Clinical Pharmacology and Therapeutics, Sofia, Bulgaria
367. 367. DOES DOES DIPYRONE DIPYRONE HAVE HAVE AN AN EFFECT EFFECT ON ON PULMONARY PULMONARY FUNCTIONS FUNCTIONS IN IN PATIENTS PATIENTS WITH WITH ASTHMA?
ASTHMA?
Gulmez Gulmez SE., SE., SE., Celik Celik G., G., Misirligil Misirligil Z., Z., T TTulunay
T Tulunay
ulunay C.
C.
Medical School of Ankara University, Department of Pharmacology and Clinical Pharmacology, Ankara, Turkey
368. 368. STUDY STUDY STUDY AND AND AND COMPARISON COMPARISON OF OF TRAMADOL TRAMADOL DEPENDENCE DEPENDENCE WITH WITH MORPHINE MORPHINE IN IN IN RATS
RATS
Rafati Rafati A AA.,
A A.,
., Ardakani Ardakani MY MY., MY MY.,
., Dashti Dashti Rahmatabadi Rahmatabadi MH MH , , P PPakdel
P Pakdel
akdel S.
S.
Shahid Sadughi Medical University, Yazd, Iran
369. 369. THE THE ROLE ROLE OF OF PHOSPHOLIPASE PHOSPHOLIPASE PHOSPHOLIPASE C C ACTIVITY ACTIVITY ACTIVITY IN IN IN SMOOTH SMOOTH SMOOTH MUSCLE MUSCLE MUSCLE RELAXING RELAXING EFFECT EFFECT OF OF DIPYRONE
DIPYRONE
Gulmez Gulmez SE., SE., Gurdal Gurdal H., H., TT
Tulunay TT
ulunay C. C.
C.
Medical School of Ankara University, Department of Pharmacology and Clinical Pharmacology, Ankara, Turkey
480. 480. 480. RENAL RENAL FUNCTION FUNCTION FUNCTION ASSESSEMENT ASSESSEMENT IN IN ELECTRONIC ELECTRONIC MEDICAL MEDICAL RECORDS-POTENTIAL RECORDS-POTENTIAL RECORDS-POTENTIAL FOR FOR INDIVIDU INDIVIDU
INDIVIDU
ALIZED ALIZED DRUG DRUG DOSAGE
DOSAGE
Sjöviker Sjöviker S. S. 1 2 3 3 1 1 1 1 , , , Söderström Söderström AA
A. AA
, , Helldén Helldén AA
A. AA
, , , Odar Odar-Cederlöf Odar -Cederlöf I. I. I. , , , Säll Säll Säll TT
T. T , , , Schönqvist Schönqvist C. C. , , , Höök Höök H. H. ,. ,. ,. Jacobsson Jacobsson L. L. ,
Bergman Bergman U. U. 3 1
, , , Gustafsson Gustafsson LL. LL.
1 Stockholm County Council Division of drug management and Informatic Huddinge
2 Farsta Health Care Centre, Carema
3 Division of Clinical pharmacology, Huddinge
POSTER POSTER SESSION SESSION 13
13
370. 370. A A DOUBLE DOUBLE BLIND BLIND BLIND RANDOMIZED RANDOMIZED PLACEBO PLACEBO CONTROLLED CONTROLLED STUDY STUDY TO TO INVESTIGATE INVESTIGATE INVESTIGATE THE THE EFFECT
EFFECT
OF OF PERSEN® PERSEN® ON ON PSYCHOMOTORIC PSYCHOMOTORIC REACTIONS REACTIONS IN IN HEALTHY HEALTHY SUBJECTS
SUBJECTS
Mrozikiewicz Mrozikiewicz Mrozikiewicz PM. PM. 1 1 2 1
, , Klusek Klusek TT
T. TT
, , Hudemowicz Hudemowicz P PP.
PP
, , Mœcisz Mœcisz A AA.
A
1 Research Institute of Medicinal Plants, Poznan, Poland
2 LEK Polska, Warszawa, Poland
372. 372. ANAPHYLACTIC ANAPHYLACTIC SHOCK SHOCK SHOCK INDUCED INDUCED BY BY DRUGS
DRUGS
Salouage Salouage I. I. 1 1 1 1 1 1 1 1
, , El El Aidli Aidli Aidli S. S. , , Kastalli Kastalli S. S. , , Srairi Srairi Srairi S. S. , , Daghfous Daghfous R. R. , , Loueslati Loueslati MH. MH. , , Lakhal Lakhal M. M. , , Belkahia Belkahia Belkahia Ch. Ch.
1 National Centre of Pharmacovigilance, Tunis, Tunisia
373. 373. DRUG-RELATED DRUG-RELATED HOSPITAL HOSPITAL ADMISSIONS ADMISSIONS DETECTED DETECTED AT AT THE THE GERMAN GERMAN PHARMACOVIGILANCE PHARMACOVIGILANCE PHARMACOVIGILANCE CENTERS
CENTERS
Thuermann Thuermann P PP.
P 1 1 2 2 3 4 5 5 , , , Haffner Haffner S. S. , , Drewelow Drewelow B. B. , , Haase Haase Haase G. G. , , Hippius Hippius M. M. , , Reimann Reimann Reimann IR. IR. , , Siegmund Siegmund W WW.
WW
, , May May K. K. ,
,
Farfel arfel E. E. 6 7
, , Hasford Hasford J. J.
1 HELIOS Klinikum Wuppertal, University Witten/Herdecke, Clinical Pharmacology, Wuppertal, Germany
2 University of Rostock, Institute of Clinical Pharmacology, Rostock, Germany
3 Friedrich Schiller University Jena, Institute of Clinical Pharmacology, Jena, Germany
4 University of Jena/Hufeland Klinikum Weimar, Institute of Clinical Pharmacology, Weimar, Germany
5 University of Greifswald, Institute of Clinical Pharmacology, Greifswald, Germany
6 University of Munich, Institute of Biostatistics and Epidemiology, Munich, Germany
7 University of Munich, Biostatistics and Epidemiology, Munich, Germany
– – –

375. 375. 375. HANDLING HANDLING OF OF DRUG DRUG RELATED RELATED RELATED PROBLEMS PROBLEMS (DRPS) (DRPS) IN IN IN MULTIDISCIPLINARY MULTIDISCIPLINARY HOSPITAL HOSPITAL TEAMS:
TEAMS:
IMPACT IMPACT OF OF THE THE DRPS’ DRPS’ CLINICAL CLINICAL SIGNIFICANCE SIGNIFICANCE AND AND PATIENT PATIENT CHARACTERISTICS
CHARACTERISTICS
Reikvam Reikvam A AA.
AA
1 2 3 4
, , Blix Blix H. H. , , Viktil Viktil Viktil K. K. , , Moger Moger T TT.
T
1 University of Oslo, Oslo, Norway
2 Lovisenberg Diakonale Hospital Pharmacy, Oslo, Norway
3 Diakonhjemmet Hospital Pharmacy, Oslo, Norway
4 University of Oslo, Section of Medical Statistics, Oslo, Norway
376. 376. CLINICO-TOXICOLOGICAL CLINICO-TOXICOLOGICAL ASSESSMENT ASSESSMENT OF OF NEWER NEWER ANTIDEPRESSANTS
ANTIDEPRESSANTS
Prasa Prasa D., D., D., Hüller Hüller G., G., Hentschel Hentschel H.
H.
Poison Information Centre, Erfurt, Germany
377. 377. 377. TOXICITY TOXICITY OF OF HYPERICUM HYPERICUM HYPERICUM PERFORATUM PERFORATUM (ST. (ST. JOHN’S JOHN’S WORT) WORT) ADMINISTERED ADMINISTERED DURING DURING LACTATION LACTATION LACTATION IN IN IN PIGS
PIGS
Mrozikiewicz Mrozikiewicz PM. PM. 1 2 3 1 1 3 1
, , K KKoziorowski
K oziorowski M. M. , , , Majewski Majewski P PP.
P , , Mielcarek Mielcarek S. S. , , Gorski Gorski M. M. M. , , Iwanik Iwanik K. K. K. , , Mscisz Mscisz A AA.
A
1 Research Institute of Medicinal Plants, Poznan, Poland
2 University of Rzeszow, Department Physiology of Animals, Rzeszow, Poland
3 University of Medical Sciences, Department of Clinical Pathology, Poznan, Poland
378. 378. THE THE EFFECT EFFECT OF OF COCULTURE COCULTURE OF OF GRANULOSA GRANULOSA CELLS CELLS IN IN HAMS' HAMS' AND AND FOLLICULAR FOLLICULAR FLUID
FLUID
ON ON HUMAN HUMAN EMBROYS EMBROYS GROWTH GROWTH AND AND DEVELOPMENT
DEVELOPMENT
Sadeghipour Sadeghipour Roudsari Roudsari HR., HR., V VVasaghi
V asaghi B.
B.
Tehran University of Medical Sciences, Tehran, Iran
379. 379. 379. COAPROVEL COAPROVEL INDUCED INDUCED HEPATOTOXICITY
HEPATOTOXICITY
HEPATOTOXICITY
Salouage alouage I., I., El El Aidli Aidli S., S., Kastalli Kastalli S., S., Srairi Srairi S., S., Daghfous Daghfous Daghfous R., R., Loueslati Loueslati Loueslati MH., MH., Lakhal Lakhal M., M., Belkahia Belkahia Belkahia Ch.
Ch.
National Centre of Pharmacovigilance, Tunis,Tunisia
381. 381. DETECTION DETECTION OF OF CLINICALLY CLINICALLY RELEVANT RELEVANT ADVERSE ADVERSE ADVERSE DRUG DRUG REACTIONS REACTIONS REACTIONS (ADRS) (ADRS) IN IN DEPARTMENTS
DEPARTMENTS
OF OF INTERNAL INTERNAL MEDICINE MEDICINE
MEDICINE
Thuermann Thuermann P PP.
P 1 1 2 2 3 1 3 , , , Szymanski Szymanski J. J. , , , Schroth Schroth Schroth U. U. , , Krahwinkel Krahwinkel W WW.
W , , , Richter Richter Richter S. S. S. , , , Haffner Haffner Haffner S. S. S. , , , Mertens Mertens AA
A. AA
, ,
,
Linke Linke J. J. 4 3
, , , Ludwig Ludwig Ludwig WD. WD.
1 HELIOS Klinikum Wuppertal, University Witten/Herdecke, Institute of Clinical Pharmacology, Wuppertal, Germany
2 HELIOS Klinikum Leisnig, Internal Medicine, Leisnig, Germany
3 HELIOS Klinikum Berlin-Buch, Charite, Robert-Roessle-Klinik, Berlin, Germany
4 HELIOS Research Center, HELIOS Kliniken, Berlin, Germany
382. 382. DRUG DRUG AND AND THERAPEUTIC THERAPEUTIC COMMITTEES COMMITTEES (DTCS (DTCS ) ) IN IN DENMARK
DENMARK
DENMARK
Raboel Raboel R. R. 1 2 1
, , Kampmann Kampmann JP JP JP. JP JP , , Christensen Christensen HR. HR. HR.
1 Bispebjerg Hospital, Clinical Pharmacology, Copenhagen, Denmark
2 Institute for Rational Pharmacotherapy, Copenhagen, Denmark
383. 383. EARLY EARLY DETECTION DETECTION AND AND TREATMENT TREATMENT TREATMENT OF OF PSYCHIATRIC PSYCHIATRIC EVENTS EVENTS IN IN PATIENTS PATIENTS WITH WITH CHRONIC
CHRONIC
HEPATITIS HEPATITIS C C C IN IN TREATMENT TREATMENT WITH WITH ALPHA-2A ALPHA-2A PEGILATED PEGILATED INTERFERON INTERFERON AND AND RIBAVIRIN
RIBAVIRIN
Borras Borras A AA.
A 1 2 3 1 2 2 1 1 , , , Montoliu Montoliu Montoliu S. S. , , Díez Díez C. C. , , V VVaqué
V aqué A AA.
A , , Planas Planas R. R. , , , Morillas Morillas R. R. , , Soler Soler A AA.
A , , Barriocanal Barriocanal A AA.
A ,
Gallardo Gallardo E. E. 1 2 1 , , Miquel Miquel M. M. , , Costa Costa J J .
1 Clinical Pharmacology Department,
2 Gastroenterology Department,
3 Psychiatry Department. University Hospital Germans Trias i Pujol. Autonomous University of Barcelona. Spain
384. 384. EVALUATION EVALUATION OF OF INDAPAMIDE INDAPAMIDE INDAPAMIDE ADVERSE ADVERSE ADVERSE DRUG DRUG REACTIONS REACTIONS AFTER AFTER SINGLE SINGLE DOSE DOSE AND AND 6 6 6 WEEKS
WEEKS
REPEATED REPEATED ORAL ORAL ADMINISTRATION ADMINISTRATION IN IN CLINICAL CLINICAL CLINICAL STUDIES
STUDIES
Kholova Kholova D. D. 1 1 2 1 1
, , , Vyslouzil Vyslouzil L. L. , , Macek Macek K. K. , , K KKopecky
KK
opecky J. J. , , Kvetina Kvetina J. J.
1 Institute of Experimental Biopharmaceutics, Hradec Kralove, Czech Republic
2 Faculty Hospital, Hradec Kralove, Czech Republic
385. 385. 385. HEPATOTOXICITY HEPATOTOXICITY DUE DUE TO TO FLUTAMIDE
FLUTAMIDE
Soler Soler Mieras Mieras A AA.
A 1 1 1 1 2 2 1 1
, , Borras Borras A AA.
A , , Barriocanal Barriocanal A AA.
A , , V VVaque
V aque A AA.
A , , Miquel Miquel M. M. , , Planas Planas R. R. , , García García F FF.
FF
, , Costa Costa Costa J. J.
1 Hospital, Clinical Pharmacology, Badalona, Spain
2 Hospital, Digestive Diseases, Badalona, Spain
– – –

386. 386. INFLIXIMAB INFLIXIMAB INFLIXIMAB AND AND QUESTIONABLE QUESTIONABLE EFFICACY EFFICACY OF OF RECOMMENDATIONS RECOMMENDATIONS ON ON TUBERCULOSIS TUBERCULOSIS SCREENING
SCREENING
Labadie Labadie J. J. 1 2
, , Diemont Diemont Diemont W WW.
W
1 Netherlands Pharmacovigilance Centre Lareb, 's-hertogenbosch, Netherlands
2 Netherlands Pharmacovigilance Centra Lareb, 's-hertogenbosch, Netherlands
387. 387. LARGE LARGE LARGE UNDERREPORTING UNDERREPORTING OF OF CEREBRAL CEREBRAL HAEMORRHAGE HAEMORRHAGE DURING DURING WARFARIN WARFARIN WARFARIN TREATMENT TREATMENT IN IN SWEDEN
SWEDEN
Jönsson Jönsson A AA.
A 1 2 1 1
, , , Andersson Andersson Andersson M. M. , , Jacobsson Jacobsson I. I. , , Hägg Hägg Hägg S. S.
1 Department of Clinical Pharmacology, University Hospital, Linköping, Sweden;
2 Depertment of Neurology, University Hospital, Linköping, Sweden
388. 388. LINKING LINKING SPONTANEOUS SPONTANEOUS REPORTS REPORTS WITH WITH PHARMACOGENETICS
PHARMACOGENETICS
Strandell Strandell J., J., Kiuru Kiuru A AA.,
A A.,
., Lindquist Lindquist M.
M.
Uppsala Monitoring Centre, Signal Detection, Uppsala, Sweden
398. 398. MONITORING MONITORING OF OF NATIONAL NATIONAL DRUG DRUG POLICY POLICY (NDP) (NDP) AND AND ITS ITS STANDARDIZED STANDARDIZED INDICATORS
INDICATORS
INDICATORS
CONFORMITY CONFORMITY TO TO DECISIONS DECISIONS OF OF NATIONAL NATIONAL DRUG DRUG SELECTING SELECTING COMMITTEE COMMITTEE COMMITTEE IN IN IN IRAN
IRAN
Abdollahi Abdollahi M. M. 1 2 1 1
, , Nikfar Nikfar S. S. , , K KKebriaeezadeh
K ebriaeezadeh A AA.
A , , Majdzadeh Majdzadeh R. R.
1 Tehran University of Medical Sciences, Tehran, Iran
2 Ministry of Health & Medical Education, Drug Selection Administion, Tehran, Iran
390. 390. NEUROLEPTIC NEUROLEPTIC MALIGNANT MALIGNANT SYNDROME SYNDROME (NMS): (NMS): A A CENTRAL CENTRAL REGISTER REGISTER OF OF CASES
CASES
Segura Segura E. E. 1 2 1
, , Saldana Saldana M. M. , , Galiana Galiana Galiana J. J.
1 Hospital U Puerto Real, Clinical Pharmacology, Puerto Real (Cádiz), Spain
2 University Hospital, Cadiz, Spain
391. 391. PARKINSONISM PARKINSONISM INDUCED INDUCED BY BY SELECTIVE SELECTIVE SEROTONIN SEROTONIN RE-UPTAKE RE-UPTAKE INHIBITOR INHIBITOR INHIBITOR ANTIDPRESSANT
ANTIDPRESSANT
ANTIDPRESSANT
(SSRI (SSRI AD): AD): AN AN AN ANALYSIS ANALYSIS ANALYSIS OF OF THE THE SPANISH SPANISH SPANISH PHARMACOVIGILANCE PHARMACOVIGILANCE DATABASE
DATABASE
Gómez Gómez - - Ontanón Ontanón E. E. 1 2 2 2 2 2
, , , Sánchez Sánchez - - Colomer Colomer Colomer MG. MG. , , , F FFernández
F ernández E. E. , , , Ramos Ramos Ramos C. C. , , , Pérez Pérez BR. BR. , , , Boada Boada JN. JN. JN.
1 University Hospital, Clinical Pharmacology Service, La Laguna – Tenerife, Spain
2 University Hospital, Pharmacovigilance Centre, La Laguna – Tenerife, Spain
392. 392. PHOTOSENSIBILITY PHOTOSENSIBILITY PHOTOSENSIBILITY INDUCED INDUCED BY BY BY METFORMIN
METFORMIN
Chaabane Chaabane A AA.
A 1 2 2 2 2 2 2 , , Kastalli Kastalli S. S. , , El El Aidli Aidli S. S. , , , T TTrabelsi
T rabelsi S. S. , , , Srairi Srairi S. S. , , , Daghfous Daghfous R. R. R. , , , Lakhal Lakhal Lakhal M. M. , ,
,
Loueslati Loueslati MH. MH. MH. 2 2
, , Belkahia Belkahia Belkahia Ch. Ch.
1 National Centre of Pharmcovigilance, Tunis, Tunisia
2 National Centre of Pharmacovigilance, Tunis, Tunisia
393. 393. POLYMORPHISMS POLYMORPHISMS OF OF MDR1 MDR1 GENE GENE IN IN IN PATIENTS PATIENTS WITH WITH ACUTE ACUTE IMMUNE IMMUNE THROMBOCYTOPENIA
THROMBOCYTOPENIA
Andersohn Andersohn F FF.,
F ., Bronder Bronder E., E., Roots Roots I., I., Garbe Garbe E.
E.
Charité - Universitaetsmedizin Berlin, Institute of Clinical Pharmacology, Berlin, Germany
394. 394. RESISTANCE RESISTANCE OF OF ENTEROBACTER ENTEROBACTER DEVELOPED DEVELOPED DURING DURING EXPOSURE EXPOSURE TO TO CEFOTAXIME
CEFOTAXIME
CEFOTAXIME
Papaioannidou apaioannidou P PP.
P 1 1 2
, , Nitsas Nitsas V VV.
V , , , Mirtsou Mirtsou - - Fidani Fidani V VV.
V
1 Aristotelian University of Thessaloniki, Medical Department, Thessaloniki, Greece
2 Aristotelian University of Thessaloniki, Medical Department, Thessaloniki, Greece
395. 395. RISK RISK FACTORS FACTORS AND AND CLINICAL CLINICAL CHARACTERISTICS CHARACTERISTICS OF OF HEPARIN-INDUCED HEPARIN-INDUCED HEPARIN-INDUCED THROMBOCYTOPENIA THROMBOCYTOPENIA WITH
WITH
AND AND WITHOUT WITHOUT THROMBOEMBOLIC THROMBOEMBOLIC COMPLICATIONS
COMPLICATIONS
Andersohn F., Bronder E., Klimpel A., Garbe E.
Charité - Universitaetsmedizin Berlin, Institute of Clinical Pharmacology, Berlin, Germany
396. 396. SAFETY SAFETY OF OF COMBINED COMBINED COMBINED HYPOLIPIDEMIC HYPOLIPIDEMIC TREATMENT TREATMENT STATINE STATINE STATINE PLUS PLUS FIBRATE
FIBRATE
Tisonova Tisonova J. J. 1 2 3 3 4 2
, , Hudec Hudec R. R. , , Raslova Raslova K. K. K. , , Horynova Horynova Z. Z. , , Blazicek Blazicek P PP.
P , , , Kriska Kriska M. M.
1 Comenius University, School of Medicine, Bratislava, Slovakia
2 Comenius University, School of Medicine, Dept of Pharmacology, Bratislava, Slovakia
3 Military Hospital, Metabolic Centre, Bratislava, Bratislava, Slovakia
4 Military Hospital, Department of Clinical Biochemistry, Bratislava, Bratislava, Slovakia
– – –

397. 397. SERUM SERUM DIGOXIN DIGOXIN DIGOXIN LEVELS LEVELS AND AND AND CLINICAL CLINICAL CLINICAL STATE STATE RELATIONSHIP: RELATIONSHIP: A A RETROSPECTIVE RETROSPECTIVE DATA DATA EVALUATION
EVALUATION
EVALUATION
H H T TTesfaye.
T esfaye. 1 2 3 4 5
, , Alusik Alusik S. S. , , Jedlickova Jedlickova Jedlickova V VV.
V , , P PPaluch
P Paluch
aluch Z. Z. , , Rocen Rocen Rocen M. M.
1 Institute for Clinical and Exper. Medicine, Prague, Czech Republic
2 Thomayerœ Teaching Hospital, Department of Medicine, Division of Clinical Pharma, Prague, Czech Republic
3 Thomayerœ Teaching Hospital, Division of Clinical Pharmacology, Prague, Czech Republic
4 THomayerœ Teahing Hospital, Division of Clinical Pharmacology, Prague, Czech Republic
5 Institute for clinical and experimental Medicine, Department of Cardio-resuscitation and Intensive Care,
Prague, Czech Republic
398. 398. SILDENAFIL SILDENAFIL INDUCED INDUCED HEMIPARESIS
HEMIPARESIS
Salouage Salouage I. I. 1 1 1 1 1 2 1 1
, , El El Aidli Aidli Aidli S. S. , , , Kastalli Kastalli S. S. , , Srairi Srairi S. S. , , , Daghfous Daghfous R. R. , , Lakhal Lakhal M. M. , , , Loueslati Loueslati MH. MH. MH. , , Belkahia Belkahia Ch. Ch.
1 National Centre of Pharmacovigilance, Tunis, Tunisia
2 National Centre of Pharmacovigilance, National Center of Pharmacovigilance, Tunis, Tunisia
399. 399. EVALUATION EVALUATION OF OF ISOSORBIDE-5-MONONITRATE ISOSORBIDE-5-MONONITRATE ADVERSE ADVERSE ADVERSE DRUG DRUG REACTIONS REACTIONS AFTER AFTER SINGLE SINGLE
SINGLE
DOSE DOSE AND AND LONG-TERM LONG-TERM (5 (5 MONTHS) MONTHS) ORAL ORAL ORAL ADMINISTRATIONS ADMINISTRATIONS IN IN CLINICAL CLINICAL CLINICAL STUDIES
STUDIES
Vyslouzil Vyslouzil L L1
1 2 1 3 2 4 1
, , K KKopecky
KK
opecky J. J. , , Macek Macek K. K. , , Kholova Kholova Kholova D. D. , , Vitovec Vitovec J. J. , , P PPospisil
P ospisil M. M. , , Munz Munz J. J. , , , Kvetina Kvetina J. J.
1 Institute of Experimental Biopharmaceutics, Hradec Kralove, Czech Republic
2 Teaching Hospital, Hradec Kralove, Czech Republic
3 Faculty of Medicine Masaryk University, Brno, Czech Republic
4 Hospital MSKB, Praha, Czech Republic
401. 401. SERUM SERUM CREATININE CREATININE AND AND GLOMERULAR GLOMERULAR FILTRATION FILTRATION RATE RATE - - SHOULD SHOULD MORE MORE CARE CARE BE BE TAKEN
TAKEN
CONCERNING CONCERNING DRUG DRUG DRUG PRESCRIBING PRESCRIBING PRESCRIBING IN IN ELDERLY ELDERLY WOMEN?
WOMEN?
Helldén Helldén A AA.
A 1 2 2 2
, , Nilsson Nilsson Nilsson G. G. G. , , Hedberg Hedberg Hedberg PP
P. P , , , Lönnberg Lönnberg Lönnberg I. I. I.
1 Karolinska Institutet, Stockholm, Sweden
2 Malardalens University, Departments of cardiology, clinical research, Central Hospital and Department of electronics,
Vasteras, Sweden,
402. 402. SPIRONOLACTONE-ASSOCIATED SPIRONOLACTONE-ASSOCIATED SEVERE SEVERE SEVERE HYPERKALIEMIA HYPERKALIEMIA : : A A SERIES SERIES OF OF 5 53
CASES
CASES
Andrejak Andrejak M. M. 1 2 3 4 5
, , , Andriamanana Andriamanana I. I. , , Gras-Champel Gras-Champel V VV.
V , , , Lemaire-Hurtel Lemaire-Hurtel AS. AS. AS. , , , Masson Masson Masson H. H. H.
1 Hospital, Amiens, France
2 Hospital, Pharmacologie Clinique - Pharmacovigilance, Amiens, France
3 Hospital, Service de Pharmacologie Clinique - Pharmacovigilance, Amiens, France
4 Hospital, Pharmacologie Clinique, Amiens, France
5 Hospital, Service de Pharmacologie Clinique, Amiens, France
403. 403. NEUROLOGICAL NEUROLOGICAL DISORDERS DISORDERS OCCURED OCCURED DURING DURING BETA-LACTAM BETA-LACTAM ANTIBIOTICS ANTIBIOTICS TREATMENT:
TREATMENT:
IMPORTANCE IMPORTANCE OF OF PLASMA PLASMA LEVELS
LEVELS
Lemaire-Hurtel Lemaire-Hurtel AS. AS. 1 2 3 4 2 5
, , Gras-Champel Gras-Champel V VV.
V , , De De Cagny Cagny Cagny B. B. , , Masmoudi Masmoudi K. K. , , Hary Hary L. L. , , Andrejak Andrejak M. M.
1 Hospital, Pharmacology, Amiens, France
2 Hospital, pharmacology, Amiens, France
3 Hospital, Nephrology, Amiens, France
4 Hospital, Neuro-pharmacology, Amiens, France
5 Hospital, Amiens, France
404. 404. 404. WEIGHT WEIGHT WEIGHT GAIN GAIN ASSOCIATED ASSOCIATED WITH WITH OLANZAPINE OLANZAPINE OLANZAPINE TREATMENT: TREATMENT: POSSIBLE POSSIBLE THERAPIES
THERAPIES
Capasso Capasso A AA.
A 1 2 2 2 2 2 2
, , , Milano Milano W WW.
W , , Del Del Del Mastro Mastro Mastro A AA.
A , , De De De Rosa Rosa M. M. , , Grillo Grillo F FF.
F , , Sanseverino Sanseverino B. B. , , PP
Petrella PP
etrella C. C.
1 Universita degli Studi di Salerno, Fisciano-Salerno, Italy
2 Unita Operativa Salute Mentale,Distretto Sanitario 44, ASL NA 1, Italy
405. 405. EFFECT EFFECT OF OF GASTROPROTECTIVE GASTROPROTECTIVE AGENTS AGENTS ON ON THE THE RISK RISK OF OF UPPER UPPER GASTROINTESTINAL GASTROINTESTINAL GASTROINTESTINAL BLEEDING
BLEEDING
ASSOCIATED ASSOCIATED WITH WITH LOW-DOSE LOW-DOSE ACETYLSALICYLIC ACETYLSALICYLIC ACID ACID USE
USE
Ibánez Ibánez L. L. 1 1 1 2 1
Vidal Vidal X. X. V VVendrell
V endrell L. L. Moretti Moretti U. U. U. Laporte Laporte JR. JR.
1 Clinical Pharmacology Unit, Hospital Universitari Vall d’Hebron, Barcelona, Spain.
2 Clinical Pharmacology Unit, Department of Medicine and Public Health, Policlinico “GB Rossi”,
University of Verona, Italy
– – –

406. 406. 406. ACUTE ACUTE LIVER LIVER DISEASE DISEASE AND AND RISK RISK ASSOCIATED ASSOCIATED TO TO DRUGS: DRUGS: DRUGS: A A CASE-POPULATION CASE-POPULATION APPROACH
APPROACH
APPROACH
Sabaté Sabaté M. M. M. 1 1,2 1,2
1,2 1,2
2
, , Pérez Pérez Pérez E. E. , , Ibánez Ibánez Ibánez L. L. , , Vidal Vidal Vidal X. X.
Grup d’Estudi Multicentric d’Hepatotoxicitat Aguda de Barcelona (GEMHAB).
1 Fundació Institut Catala de Farmacologia, Barcelona, Spain;
2 Hospital Universitari Vall d’Hebron, Barcelona, Spain
407. 407. ASSESSMENT ASSESSMENT OF OF DRUG-INDUCED DRUG-INDUCED GASTROINTESTINAL GASTROINTESTINAL DISEASES DISEASES IN IN SURGERY
SURGERY
Hippius Hippius M. M. M. 1 2 , , K KKoch
K Koch
och C. C.
1 Friedrich Schiller University Jena, Jena, Germany
2 Friedrich Schiller University, Medical Faculty (Klinikum), Clinical Pharmacology, Jena, Germany
408. 408. SAFETY SAFETY AND AND TOLERABILITY TOLERABILITY OF OF AZITHROMYCIN AZITHROMYCIN DURING DURING TRAETMENT TRAETMENT OF OF COMMON
COMMON
INTECTIOUS INTECTIOUS DISEASES: DISEASES: 2004 2004 -2005 -2005
-2005
Mrdjen Mrdjen A AA.
A
Clinical Hospital Centre, Zagreb, Croatia
POSTER POSTER SESSION SESSION 14
14
409. 409. DISCREPANCIES DISCREPANCIES BETWEEN BETWEEN FAMILY FAMILY FAMILY DOCTOR DOCTOR AND AND HOSPITAL HOSPITAL DRUG DRUG LISTS
LISTS
Raboel Raboel R. R. 1 1 1 1 1 2 3
, , Arroe Arroe G. G. , , , Langergaard Langergaard MT MT. MT , , F FFolke
F Folke
olke F FF.
F , , Madsen Madsen KR. KR. , , Budek Budek T TT.
T , , Andersen Andersen JR. JR.
1 Storstroemmens sygehus, Nykoebing Falster, Internal medicine, Nykoebing Falster, Denmark
2 The Quality Unit of General Practice (FUAP), Storstroem County, Nykoebing Falster, Denmark
3 Royal Veterinary and Agricultural University, Department of Human Nutrition, Copenhagen, Denmark
413. 413. PRIMARY PRIMARY NON-COMPLIANCE NON-COMPLIANCE IN IN IN PATIENTS PATIENTS PATIENTS USING USING HYPOLIPIDEMICS
HYPOLIPIDEMICS
J J Strojil., Strojil., K K Urbánek., Urbánek., Sobolová Sobolová L.
L.
Palacký University, Medical Faculty, Dep. of Pharmacology, Olomouc, Czech Republic
414. 414. USE USE OF OF ANTIBIOTICS ANTIBIOTICS IN IN CLINICAL CLINICAL CLINICAL CENTRE CENTRE CENTRE NIS
NIS
Velickovic elickovic elickovic - - Radovanovic Radovanovic R. R. 1 1 1 1
, , , Lilic Lilic R. R. , , P PPetrovic
P etrovic J. J. , , , P PPesic
P esic S. S.
1 Institute Of Nephrology & Haemodialysis, Nis, Yugoslavia
415. 415. A A STUDY STUDY ON ON THE THE PHARMACOKINETICS PHARMACOKINETICS PROPERTIES PROPERTIES OF OF A A 5 5 - - ETHOXY-2-[2-(MORPHOLINO)-ETHYL
ETHOXY-2-[2-(MORPHOLINO)-ETHYL
THIO]-BENZIMIDASOLE THIO]-BENZIMIDASOLE DERIVED DERIVED DERIVED FROM FROM FROM 2-MERCAPTOBENZIMIDASOLE.
2-MERCAPTOBENZIMIDASOLE.
Hazar H., Hazar A.
Duzce Medical School, Department of Pharmacology, Duzce, Turkey
416. 416. ANTIBIOTIC ANTIBIOTIC PRESCRIBING PRESCRIBING PATTERNS PATTERNS PATTERNS FOR FOR PRESCHOOL PRESCHOOL CHILDREN CHILDREN WITH WITH WITH ACUTE ACUTE ACUTE TONSILLOPHARYN-
TONSILLOPHARYN-
GITIS GITIS AND AND ACUTE ACUTE OTITIS OTITIS MEDIA: MEDIA: A A SURVEY SURVEY AMONG AMONG PHYSICIANS PHYSICIANS IN IN BOSNIA BOSNIA BOSNIA AND AND HERZEGOVINA
HERZEGOVINA
Skrbic Skrbic R. R. 1 1 2 2
, , , Stoisavljevic-Satara Stoisavljevic-Satara S. S. , , Stojakovic Stojakovic Stojakovic N. N. , , Nezic Nezic L. L.
1 Banja Luka University, Department of Pharmacology, Medical Faculty, Banja Luka, Bosnia
2 Banja Luka University, Department of Pharmacology, Medical faculty, Banja Luka, Bosnia
POSTER POSTER SESSION SESSION SESSION 15 15
15
417. 417. 417. CALCYTONIN CALCYTONIN RECEPTOR RECEPTOR RECEPTOR GENE GENE CTR CTR POLYMORPHISMS POLYMORPHISMS (ALUI) (ALUI) IN IN IN POLISH POLISH POSTMENOPAUSAL POSTMENOPAUSAL POSTMENOPAUSAL WOMEN
WOMEN
Bartkowiak-
Bartkowiak-Wieczorek Bartkowiak- ieczorek J. J. 1 1, 1, 2 2 2
2 2 2
, , KK
Kurzawiñska KK
urzawiñska G. G. , , Seremak-Mrozikiewicz Seremak-Mrozikiewicz A AA.
A , , Drews Drews K. K. K. , , , Mrozikiewicz Mrozikiewicz PM. PM. PM.
1 Research Institute of Medicinal Plants, Poznañ, Poland,
2 Clinic of Perinatology and Gynecology University of Medical Sciences in Poznañ, Poland
481. 481. ASSOCIATION ASSOCIATION OF OF VITAMIN VITAMIN D D D (TaqI) (TaqI) (TaqI) AND AND ESTROGEN ESTROGEN RECEPTOR RECEPTOR GENE GENE (ER?: (ER?: PvuII, PvuII, XbaI)
XbaI)
POLYMORPHISM POLYMORPHISM WITH WITH OSTEOPOROSIS OSTEOPOROSIS .
.
Bartkowiak-
Bartkowiak-Wieczorek Bartkowiak- ieczorek J. J. 1 2 1, 1, 2 2
2 2
, , Seremak-Mrozikiewicz Seremak-Mrozikiewicz A AA.
A , , KK
Kurzawiñska K urzawiñska G. G. , , Drews Drews K. K. K. , , , Mrozikiewicz Mrozikiewicz PM. PM. PM.
1 Research Institute of Medicinal Plants, Poznañ, Poland,
2 Clinic of Perinatology and Gynecology University of Medical Sciences in Poznañ, Poland
– – –

418. 418. INFLUENCE INFLUENCE OF OF DIFFERENT DIFFERENT CYP CYP AND AND AND MDR1 MDR1 MDR1 POLYMORPHISMS POLYMORPHISMS ON ON VORICONAZOLE VORICONAZOLE VORICONAZOLE PHARMACOKINETICS
PHARMACOKINETICS
Mikus Mikus1
1 1 1 2 3 1 G., G., Drzewinska1 Drzewinska1 M., M., Schoewel Schoewel Schoewel V VV.,
V ., Burhenne Burhenne Burhenne J., J., Riedel Riedel Riedel KD., KD., Thomsen Thomsen T TT.,
T ., Hoffmann Hoffmann Hoffmann MM., MM., MM., W WWeiss
W eiss J., J.,
J.,
Rengelshausen Rengelshausen1
1 J., J., Haefeli Haefeli WE.
WE.
1 University of Heidelberg, Clinical Pharmacology and Pharmacoepidemiology, Heidelberg, Germany
2 Pharm PlanNet, Mönchengladbach, Germany
3 University of Freiburg, Clinical Chemistry, Freiburg, Germany
419. 419. ANTIPYRINE ANTIPYRINE ANTIPYRINE HALF-LIFE HALF-LIFE AS AS PREDICTOR PREDICTOR OF OF NEUROLEPTIC NEUROLEPTIC TOLERABILITY TOLERABILITY IN IN SHIZOPHRENIC SHIZOPHRENIC PATIENTS
PATIENTS
Vedernikova edernikova O1., O1., Ziganshina Ziganshina L. L. 1, 1, K KKuchaeva
K Kuchaeva
uchaeva A AA.
A . 1, 1, Gatin Gatin Gatin F FF.
F . 2
2
1 Kazan State Medical Academy, Clinical Pharmacology and Pharmacotherapy, Kazan, Russia
2 Republican Clinical Psychiatric hospital, Psychiatry, Kazan, Russia
420. 420. EFFECT EFFECT OF OF CLOPIDOGREL CLOPIDOGREL AND AND TICLOPIDINE TICLOPIDINE ON ON CYP CYP 2B6 2B6 ACTIVITY ACTIVITY AS AS MEASURED
MEASURED
BY BY BUPROPION BUPROPION BUPROPION HYDROXYLATION
HYDROXYLATION
HYDROXYLATION
Turpeinen urpeinen M. M. 1 2 2 1 1 3
, , T TTolonen
T olonen A AA.
A , , Uusitalo Uusitalo J. J. , , Jalonen Jalonen J. J. , , P PPelkonen
P elkonen O OO.
O , , Laine Laine K. K.
1 University of Oulu, Dept. of Pharmacology and Toxicology, Oulu, Finland
2 Novamass Analytical, Oulu, Finland
3 University of Turku, Dept. of Pharmacology and Clinical Pharmacology, Turku, Finland
421. 421. GENETIC GENETIC POLYMORPHISM POLYMORPHISM AND AND CHEMICAL CHEMICAL CARCINOGENESIS: CARCINOGENESIS: ASSESSMENT ASSESSMENT OF OF THE THE ENZYMES’
ENZYMES’
NAT2, NAT2, CYP2A6 CYP2A6 AND AND CYP1A2 CYP1A2 CYP1A2 METABOLIZING METABOLIZING ACTIVITY ACTIVITY AMONG AMONG AMONG GREEK GREEK LUNG LUNG CANCER CANCER PATIENTS
PATIENTS
AND AND CONTROLS.
CONTROLS.
Drakoulis Drakoulis N. N. 1 1 1 1 2 3 3
, , Malliara Malliara E. E. , , Balaskonis Balaskonis K. K. , , Haliassos Haliassos E. E. , , Bauer Bauer S. S. , , Skarleas Skarleas C. C. , , K KKyprianou
K Kyprianou
yprianou K. K. K.
1 University of Athens, School of Pharmacy, Greece
2 Charite University Medicine Berlin, Germany
3 Euromedica Hospital, Athens, Greece
422. 422. FETAL FETAL EXPRESSION EXPRESSION AND AND POSTNATAL POSTNATAL MATURATION MATURATION OF OF P-GLYCOPROTEIN P-GLYCOPROTEIN IN IN RATS RATS
RATS
Lederer Lederer K., K., Möritz Möritz Möritz KK
KU., K U., Siegmund Siegmund WW
W., WW
., Dazert Dazert Dazert E., E., WW
Warzok WW
arzok arzok R.
R.
University of Greifswald, Department of Clinical Pharmacology, Greifswald, Germany
423. 423. PHARMACOGENETIC PHARMACOGENETIC NOMENCLATURE NOMENCLATURE NOMENCLATURE OR OR “AS “AS YOU YOU LIKE LIKE LIKE IT”
IT”
Niewiñski Niewiñski Niewiñski P PP.
P
Department of Clinical Pharmacology, Wroclaw Medical University, Wroc³aw, Poland
424. 424. COMPARATIVE COMPARATIVE PHARMACOKINETICS PHARMACOKINETICS OF OF OF VITAMIN VITAMIN K K ANTAGONISTS
ANTAGONISTS
Ufer Ufer Ufer M.
M.
University Hopital Schleswig-Holstein, Institute of Pharmacology, Kiel, Germany
426. 426. POPULATION POPULATION PHARMACOKINETICS PHARMACOKINETICS OF OF IMATINIB IMATINIB IN IN CML CML AND AND GIST GIST PATIENTS PATIENTS UNDER
UNDER
LONG-TERM LONG-TERM TREATMENT
TREATMENT
Widmer idmer N. N. 1 1 1 1 2 1 1
, , Decosterd Decosterd Decosterd LA LA. LA , , Leyvraz Leyvraz Leyvraz S. S. S. , , Duchosal Duchosal MA MA. MA , , Csajka Csajka C. C. , , Biollaz Biollaz J. J. , , Buclin Buclin T TT.
T
1 Centre Hospitalier Universitaire Vaudois, Division de Pharmacologie et Toxicologie cliniques, Lausanne, Switzerland
2 University of California, Biopharmaceutical Sciences Department, San Francisco, USA
427. 427. ESOMEPRAZOLE ESOMEPRAZOLE AND AND AND GASTROOESOPHAGEAL GASTROOESOPHAGEAL REFLUX REFLUX DISEASE DISEASE (GERD): (GERD): INFLUENCE INFLUENCE OF OF CYP2C19
CYP2C19
GENOTYPE GENOTYPE ON ON CLINICAL CLINICAL CLINICAL OUTCOME
OUTCOME
Klotz Klotz U. U. 1 1 2 1 1 2 2
, , , Schwab Schwab M. M. , , Leodolter Leodolter Leodolter A AA.
A , , Hofmann Hofmann U. U. , , Schäffeler Schäffeler E. E. , , Malfertheiner Malfertheiner PP
P. PP
, , TT
Treiber T Treiber
reiber G. G. G.
1 Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
2 Department of Gastroenterology, University Hospital, Magdeburg, Germany
428. 428. THIOPURINE THIOPURINE METHYLTRANSFERASE METHYLTRANSFERASE (TPMT) (TPMT) AS AS A A TARGET TARGET FOR FOR DRUG DRUG INTERACTIONS
INTERACTIONS
Xin Xin H., H., Fischer Fischer C., C., C., Schwab Schwab Schwab M., M., Klotz Klotz U.
U.
Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
429. 429. 429. METABOLISM METABOLISM METABOLISM OF OF OF REPAGLINIDE REPAGLINIDE REPAGLINIDE BY BY CYP2C8 CYP2C8 CYP2C8 AND AND CYP3A4 CYP3A4 IN IN VITRO: VITRO: VITRO: EFFECT EFFECT OF OF OF FIBRATES
FIBRATES
AND AND RIFAMPICIN
RIFAMPICIN
Kajosaari Kajosaari L., L., Laitila Laitila J., J., Neuvonen Neuvonen P PP.,
P ., Backman Backman J.
J.
University of Helsinki, Department of Clinical Pharmacology, Helsinki, Finland
– – –

430. 430. 430. THE THE IMPACT IMPACT OF OF THIOPURINE THIOPURINE S-METHYLTRANSFERASE S-METHYLTRANSFERASE S-METHYLTRANSFERASE POLYMORPHISM POLYMORPHISM ON ON AZATHIOPRINE-
AZATHIOPRINE-
INDUCED INDUCED MYELOTOXICITY MYELOTOXICITY IN IN IN RENAL RENAL TRANSPLANT TRANSPLANT RECIPIENTS
RECIPIENTS
Kurzawski urzawski M. M. M. 1 2 1 1 1
, , Dziewanowski Dziewanowski K. K. , , , Gawronska-Szklarz Gawronska-Szklarz Gawronska-Szklarz B. B. , , Domanski Domanski L. L. , , Drozdzik Drozdzik M. M.
1 Pomeranian Medical University, Department of Experimental and Clinical Pharmacology, Szczecin, Poland
2 Department of Nephrology and Dialysis, County Hospital, Szczecin, Poland
431. 431. SEVERE SEVERE AZATHIOPRINE-INDUCED AZATHIOPRINE-INDUCED MYELOTOXICITY MYELOTOXICITY IN IN CROHN'S CROHN'S DISEASE DISEASE PATIENT PATIENT WITH
WITH
THIOPURINE THIOPURINE S-METHYLTRANSFERASE S-METHYLTRANSFERASE DEFICIENT DEFICIENT GENOTYPE GENOTYPE (TPMT*3A/*3A)
(TPMT*3A/*3A)
Kurzawski urzawski urzawski M., M., Zdziarska Zdziarska B., B., W WWierzbicka-P
WW
ierzbicka-P ierzbicka-Paczos ierzbicka-P aczos E., E., Chosia Chosia M., M., P PPawlik
PP
awlik A AA.,
A ., Drozdzik Drozdzik M.
M.
Pomeranian Medical University, Department of Experimental and Clinical Pharmacology, Szczecin, Poland
432. 432. IMPACT IMPACT OF OF 5-HT2A 5-HT2A POLYMORPHISMS POLYMORPHISMS ON ON CLINICAL CLINICAL OUTCOME OUTCOME IN IN SCHIZOPHRENIC SCHIZOPHRENIC PATIENTS
PATIENTS
TREATED TREATED WITH WITH WITH RISPERIDONE
RISPERIDONE
Scordo Scordo MG. MG. MG. 1 1 2 1
, , , Gunes Gunes Gunes A AA.
A , , Spina Spina E. E. , , Dahl Dahl M-L M-L
1 Uppsala University, Department of Medical Sciences, Clinical Pharmacology, Uppsala, Sweden
2 University of Messina, Department of Clinical and Experimental Medicine and Pharmacology, Messina, Italy
433. 433. EVALUATION EVALUATION OF OF CLINICOPATHOLOGICAL CLINICOPATHOLOGICAL SIGNIFICANCE SIGNIFICANCE OF OF P53 P53 EXPRESSION EXPRESSION IN IN RELATION
RELATION
TO TO BCL-2, BCL-2, P-GLYCOPROTEIN, P-GLYCOPROTEIN, TOPO TOPO II II ALPHA, ALPHA, TS TS AND AND TP TP EXPRESSION EXPRESSION IN IN COLORECTAL
COLORECTAL
CANCER CANCER PATIENTS
PATIENTS
Arbabi-Bidgoli Arbabi-Bidgoli Arbabi-Bidgoli S. S. 1 2 2 2
, , Minaee Minaee B. B. , , Zavarhei Zavarhei MD. MD. MD. , , Azizi Azizi E. E.
1 Islamic Azad University,Faculty of Pharmacy, Toxicology and Pharmacology, Tehran, Iran
2 Tehran University of Medical Sciences, Anatomy and Embryology, Tehran, Iran
434. 434. RESULTS RESULTS RESULTS OF OF PARACETAMOL PARACETAMOL GENOTOXICITY GENOTOXICITY EVALUATION
EVALUATION
Kapic Kapic E., E., E., TT
Todic TT
odic odic M., M., Becic Becic FF
F., FF
., ., K KKusturica
K Kusturica
usturica J., J., Aganovic-Musinovic Aganovic-Musinovic I., I., Mulabegovic Mulabegovic N.
N.
Faculty of Medicine, Institute of Pharmacology, Clinical Pharmacology and Toxicology, Sarajevo, Bosnia
435. 435. 435. EFFECTS EFFECTS OF OF CYP3A5 CYP3A5 AND AND MDR1 MDR1 POLYMORPHISMS POLYMORPHISMS ON ON TACROLIMUS TACROLIMUS TACROLIMUS KINETICS KINETICS KINETICS OF OF KIDNEY
KIDNEY
TRANSPLANT TRANSPLANT RECIPIENTS
RECIPIENTS
Frisman risman M., M., Renders Renders L., L., Mosyagin Mosyagin Mosyagin I., I., Haenisch Haenisch Haenisch S., S., Cascorbi Cascorbi I. I.
I.
University Hopital Schleswig-Holstein, Institute of Pharmacology, Kiel, Germany
436. 436. PHENOTYPIC PHENOTYPIC PHARMACOKINETICS PHARMACOKINETICS OF OF TRAMADOL TRAMADOL TRAMADOL AND AND MIOTIC MIOTIC RESPONSE
RESPONSE
Slanar Slanar O OO.
O 1 2 2 3 1
, , Nobilis Nobilis Nobilis M. M. M. , , , Kvetina Kvetina J. J. , , , Idle Idle JR. JR. , , P PPerlik
P erlik F FF.
F
1 Institute for Postgraduate Medical Education, Prague, Czech Republic
2 Institute of Experimental Biopharmaceutics, Hradec Kralove, Czech Republic
3 Institue of Pharmacology, Charles University, Prague, Czech Republic
437. 437. POLYMORPHIC POLYMORPHIC ORGANIC ORGANIC ANION ANION ANION TRANSPORTING TRANSPORTING TRANSPORTING POLYPEPTIDE POLYPEPTIDE 1B1 1B1 1B1 (OATP1B1) (OATP1B1) IS IS A A A MAJOR
MAJOR
DETERMINANT DETERMINANT OF OF REPAGLINIDE REPAGLINIDE PHARMACOKINETICS
PHARMACOKINETICS
Niemi Niemi M. M. 1 1 1 2 1 2 3 3 , , Backman Backman JT JT. JT , , Kajosaari Kajosaari LI. LI. , , Leathart Leathart JB. JB. JB. , , Neuvonen Neuvonen M. M. , , Daly Daly Daly AK. AK. , , Eichelbaum Eichelbaum M. M. , , Kivisto Kivisto KT KT. KT ,
Neuvonen Neuvonen PJ. PJ. 1
1 University of Helsinki, Department of Clinical Pharmacology, Helsinki, Finland
2 University of Newcastle Medical School, Pharmacogenetics group, School of Clinical and Laboratory Sciences,
Newcastle Upon Tyne, UK
3 Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
439. 439. POLYMORPHISMS POLYMORPHISMS OF OF THE THE THE MDR1 MDR1 GENE GENE GENE IN IN THE THE CZECH CZECH POPULATION
POPULATION
Niemi Niemi M. M. 1 1 1 2 1 2 3 3 , , Backman Backman JT JT. JT , , Kajosaari Kajosaari LI. LI. , , Leathart Leathart JB. JB. JB. , , Neuvonen Neuvonen Neuvonen M. M. , , Daly Daly Daly AK. AK. , , Eichelbaum Eichelbaum M. M. , , Kivisto Kivisto Kivisto KT KT. KT ,
Neuvonen Neuvonen PJ. PJ. 1
First Faculty of Medicine, Charles University, Clinical Pharmacology Unit, Department of Pharmacology, Prague,
Czech Republic
440. 440. ORAL ORAL CONTRACEPTIVES CONTRACEPTIVES CONTAINING CONTAINING ETHINYL ETHINYL ESTRADIOL ESTRADIOL AND AND GESTODENE GESTODENE CONSIDERABLY
CONSIDERABLY
INCREASE INCREASE PLASMA PLASMA PLASMA CONCENTRATIONS CONCENTRATIONS OF OF TIZANIDINE TIZANIDINE BY BY BY INHIBITING INHIBITING CYP1A2
CYP1A2
Granfors Granfors M., M., Backman Backman JT JT., JT ., Neuvonen Neuvonen M., M., Neuvonen Neuvonen PJ. PJ.
PJ.
University of Helsinki, Department of Clinical Pharmacology, Helsinki, Finland
– – –

441. 441. 441. FREQUENCY FREQUENCY OF OF SINGLE SINGLE NUCLEOTIDE NUCLEOTIDE POLYMORPHISMS POLYMORPHISMS POLYMORPHISMS OF OF OF CYP2D6 CYP2D6 IN IN THE THE CZECH CZECH CZECH POPULATION
POPULATION
Buzkova Buzkova H., H., P PPechandova
PP
echandova K., K., Slanar Slanar Slanar O OO.,
O ., P PPerlik
P erlik F FF.
FF
First Faculty of Medicine, Charles University, Clinical Pharmacology Unit, Department of Pharmacology, Prague,
Czech Republic
442. 442. INFLUENCE INFLUENCE OF OF OF CYP2B6 CYP2B6 POLYMORPHISM POLYMORPHISM POLYMORPHISM ON ON THE THE STEADY-STATE STEADY-STATE PLASMA PLASMA LEVELS LEVELS
LEVELS
OF OF THE THE ENANTIOMERS ENANTIOMERS OF OF METHADONE
METHADONE
Crettol Crettol S., S., Deglon Deglon JJ., JJ., Besson Besson Besson J., J., Croquette Croquette Krokkar Krokkar M., M., Gottuey Gottuey I., I., Haemmig Haemmig R., R., Monnat Monnat M., M., M., Haottemann Haottemann H.,
H.,
Baumann Baumann PP
P., P ., Eap Eap CB.
CB.
University Department of Adult Psychiatry - Centre for Psychiatric Neurosciences, Prilly-Lausanne, Switzerland
443. 443. PREVALENCE PREVALENCE OF OF POLYMORPHISMS POLYMORPHISMS IN IN THE THE THE GENES GENES FOR FOR MDR1 MDR1 AND AND UGT1A UGT1A AND
AND
OF OF THE THE CORRESPONDING CORRESPONDING HAPLOTYPES HAPLOTYPES IN IN THE THE UGT1A-GENE UGT1A-GENE IN IN IN A A COHORT COHORT OF OF VOLUNTEERS
VOLUNTEERS
FROM FROM SOUTHERN SOUTHERN SWEDEN SWEDEN AND AND IN IN A A HUMAN HUMAN DIVERSITY DIVERSITY PANEL
PANEL
Mercke-Odeberg Mercke-Odeberg J. J. 1 2 2 1 1 2
, , Holmberg Holmberg K. K. , , Andrade Andrade J. J. , , Hoglund Hoglund P PP.
P , , Malmqvist Malmqvist Malmqvist U. U. U. , , Odeberg Odeberg Odeberg J. J. J.
1 Lund University Hospital, Dept. of Clinical Pharmacology, Lund, Sweden
2 KTH - Royal inst of Technology, Molecular Biotechnology, Stockholm, Sweden
444. 444. PHENOTYPE PHENOTYPE AND AND GENOTYPE GENOTYPE BETWEEN BETWEEN ITALIAN ITALIAN CHILDREN CHILDREN AND AND ADULTS ADULTS FOR FOR THIOPURINE
THIOPURINE
METHYLTRANSFERASE
METHYLTRANSFERASE
Canaparo Canaparo R. R. 1 1 2 1 1 1 1
, , Serpe Serpe L. L. , , Calvo Calvo GL. GL. , , Barbera Barbera Barbera C. C. C. , , Muntoni Muntoni E. E. , , Eandi Eandi M. M. , , Zara Zara GP GP GP. GP
1 University of Torino, Torino, Italy
2 OIRM, Gastroenterology, Torino, Italy
445. 445. THE THE THE RELATIONSHIP RELATIONSHIP BETWEEN BETWEEN CYP2C9 CYP2C9 CYP2C9 GENOTYPE GENOTYPE AND AND AND EXPOSURE EXPOSURE TO TO THE THE THE COX2-INHIBITOR COX2-INHIBITOR CELECOXIB
CELECOXIB
Eliasson Eliasson E. E. 1 1 1 2 1 1
, , Ohlsson Ohlsson S. S. S. , , , Johansson Johansson P PP.
P , , , Nordin Nordin Nordin K. K. , , , Lafolie Lafolie P PP.
P , , , Lundblad Lundblad Lundblad SM. SM. SM.
1 Karolinska Institutet, Clinical Pharmacology, Karolinska University Hospital Huddinge, Stockholm, Sweden
2 Karolinska Institutet, Clinical Pharmacology, Stockholm, Sweden
446. 446. CYP3A CYP3A AND AND MDR1 MDR1 (P-GLYCOPROTEIN) (P-GLYCOPROTEIN) GENE GENE EXPRESSION EXPRESSION LEVELS LEVELS ALONG ALONG THE THE HUMAN
HUMAN
GASTROINTESTINAL GASTROINTESTINAL TRACT
TRACT
Canaparo Canaparo R. R. 1 2 3 4 2 5 1 , , , Nordmark Nordmark AA
A. AA
, , , Finnstrom Finnstrom Finnstrom N. N. N. , , , Lundgren Lundgren Lundgren S. S. , , Seidegard Seidegard Seidegard J. J. , , , Jeppsson Jeppsson Jeppsson B. B. , , , Serpe Serpe Serpe L. L. L. ,
Eandi Eandi M. M. 1 1 4
, , Zara Zara GP GP. GP ,Rane ,Rane ,Rane A AA.
A
1 University of Torino, Torino, Italy
2 AstraZeneca, Stockholm, Sweden
3 Sangtec Molecular, Stockholm, Sweden
4 Karolinska Institutet, Clinical Pharmacology, Stockholm, Sweden
5 Malmo University Hospital, Department of Surgery, Malmo,Sweden
447. 447. DETERMINATION DETERMINATION OF OF THE THE WARFARIN WARFARIN METABOLISM METABOLISM METABOLISM GENETIC GENETIC GENETIC DIVERSITY DIVERSITY USING USING HIGH
HIGH
PERFORMANCE PERFORMANCE LIQUID LIQUID CHROMATOGRAPHY
CHROMATOGRAPHY
Ghasemi Ghasemi N., N., Mosadegh Mosadegh M.
M.
Yazd Medical Sciences University, Yazd, Iran
448. 448. 448. DETERMINATION DETERMINATION DETERMINATION OF OF TPMT TPMT ACTIVITY ACTIVITY IN IN HUMAN HUMAN HUMAN ERYTHROCYTES: ERYTHROCYTES: CONDITIONS
CONDITIONS
FOR FOR FOR REVERSED-PHASE REVERSED-PHASE HPLC-UV-DETECTION
HPLC-UV-DETECTION
Oselin Oselin Oselin K., K., Anier Anier K., K., V VVaarmann
V Vaarmann
aarmann A AA.,
A ., Maeorg Maeorg U. U.
U.
Tartu University, Department of Pharmacology, Tartu, Estonia
449. 449. CYTOCHROME CYTOCHROME P450 P450 P450 1A2 1A2 (CYP1A2) (CYP1A2) ALLELE ALLELE ALLELE FREQUENCIES FREQUENCIES IN IN IN A A TURKISH TURKISH POPULATION
POPULATION
Gunes Gunes A AA.
A 1 1 2 2 3 3 1
, , Scordo Scordo MG. MG. , , , Ozbey Ozbey G. G. G. , , Uluoglu Uluoglu C. C. C. , , Bumin Bumin MA MA. MA , , Zengil Zengil H. H. , , Dahl Dahl Dahl ML ML
1 Uppsala University, Medical Sciences,Clinical Pharmacology, Uppsala, Sweden
2 Gazi University,Faculty of Medicine, Medical Pharmacology, Ankara, Turkey
3 Gazi University, Faculty of Medicine, Public Health, Ankara, Turkey
450. 450. 450. URINARY URINARY TRAMADOL TRAMADOL METABOLITES METABOLITES IN IN IN EARLY EARLY NEONATAL NEONATAL LIFE: LIFE: IN IN VIVO VIVO ASSESSMENT
ASSESSMENT
OF OF PHENOTYPIC PHENOTYPIC CYP2D6 CYP2D6 ACTIVITY ACTIVITY
ACTIVITY
Allegaert Allegaert K. K. 1 1 1 1 2 2 1
, , V VVerbesselt
V erbesselt R. R. , , De De De Hoon Hoon J. J. , , Naulaers Naulaers G. G. , , Tibboel Tibboel Tibboel D. D. , , V VVan
VV
an Den Den Anker Anker J. J. , , Devlieger Devlieger H. H.
1 University Hospital, Gasthuisberg, Leuven, Belgium
2 Erasmus MC, Sophia's Children's Hospital, Department of Paediatric Surgery, Rotterdam, Netherlands

451. 451. 451. IMPACT IMPACT OF OF OF CYP2C9 CYP2C9 GENOTYPES GENOTYPES GENOTYPES ON ON THE THE PHARMACOKINETICS PHARMACOKINETICS PHARMACOKINETICS OF OF OF SILDENAFIL
SILDENAFIL
Jetter Jetter Jetter A AA.
A 1 1 2 1 2 1 , , Lazar Lazar Lazar A AA.
A , , Kinzig-Schippers Kinzig-Schippers Kinzig-Schippers M. M. , , WW
Walchner W alchner alchner-Bonjean alchner -Bonjean M. M. M. , , Bulitta Bulitta Bulitta J. J. , , Schreiner Schreiner Schreiner P PP.
P ,
Soergel Soergel F FF.
F 2 1 , , F FFuhr
F Fuhr
uhr U. U.
1 University of Cologne, Department of Pharmacology, Clinical Pharmacology, Koeln, Germany
2 Institute for Biomedical and Pharmaceutical Research, Nürnberg-Heroldsberg, Germany
452. 452. PHARMACOGENETIC PHARMACOGENETIC INFLUENCES INFLUENCES ON ON BISOPROLOL BISOPROLOL AND AND METOPROLOL METOPROLOL PHARMACOKINETICS
PHARMACOKINETICS
Kuhn uhn UD.1, UD.1, Heinze Heinze C.1, C.1, Merkel Merkel U.1, U.1, Hippius Hippius M.1, M.1, Dannberg Dannberg G. G. 2
1 Friedrich Schiller University Jena, Inst. of Clinical Pharmacology, Jena, Germany
2 Department of Internal Medicine I (Cardiology), University Hospital, Jena, Germany
453. 453. LACK LACK OF OF OF ASSOCIATION ASSOCIATION BETWEEN BETWEEN ACE ACE GENE GENE POLYMORPHISM POLYMORPHISM AND AND SERUM SERUM LEPTIN LEPTIN LEPTIN LEVEL
LEVEL
Jankowska Jankowska K.1, K.1, K.1, Gluszek Gluszek J. J. 2 2 2
, , Zaporowska-Stachowiak Zaporowska-Stachowiak I. I. , , , Bobkiewicz-K
Bobkiewicz-Koz³owska Bobkiewicz-K
Bobkiewicz-Koz³owska
oz³owska TT
T. TT
1 Poznan University of Medical Sciences, Poznan, Poland
2 Poznan University of Medical Sciences, Department of Arterial Hypertension, Poznan, Poland
454. 454. CYP2D6 CYP2D6 GENOTYPE GENOTYPE IN IN RELATION RELATION TO TO STEADY STEADY STATE STATE CONCENTRATIONS CONCENTRATIONS OF OF MIRTAZAPINE,
MIRTAZAPINE,
N-DESMETHYLMIRTAZAPINE N-DESMETHYLMIRTAZAPINE AND AND THEIR THEIR ENANTIOMERS
ENANTIOMERS
Lind Lind A-B. A-B. 1 2 3 2 2-4 2-4
4 1
, , Reis Reis M. M. , , Bengtsson Bengtsson F FF.
FF
, , , Ahlner Ahlner J. J. , , Eap Eap C. C. , , Baumann Baumann P PP.
PP
, , Dahl Dahl ML. ML.
1 Uppsala University, Dept of Medical Sciences, Clinical Pharmacology, Uppsala, Sweden
2 National Board of Forensic Medicine, Dept of Forensic Chemistry, Linköping, Sweden
3 Linköping University, Dept of Medicine and Care, Clinical Pharmacology, Linköping, Sweden
4 University Department of Adult Psychiatry, Unité de Biochimie et Psychopharmacologie Clinique, Lausanne,
Switzerland
455. PHENPROCOUMON ASSOCIATED BLEEDING EVENTS: ROLE OF CYP2C9 GENOTYPE COMPARED
TO OTHER COFACTORS
Haffner Haffner S. S. 1 2 3 1 4
, , , K KKuhn
K uhn UD. UD. , , , Haase Haase G. G. , , , Thuermann Thuermann Thuermann P PPA.
P , , , Joerg Joerg Joerg Hasford Hasford Hasford
1 HELIOS Klinikum Wuppertal, University Witten/Herdecke, Philipp Klee-Institute of Clinical Pharmacology,
Wuppertal, Germany
2 Friedrich Schiller University Jena, Institute of Clinical Pharmacology, Jen, Germany
3 University of Rostock, Institute of Clinical Pharmacology, Rostock, Germany
4 Ludwig-Maximilians-University, Institute of Biostatistics and Epidemiology, Munich, Germany
457. 457. LINK LINK BETWEEN BETWEEN FASTING FASTING SERUM SERUM LEPTIN LEPTIN LEVEL LEVEL AND AND FIBRINOGEN FIBRINOGEN FIBRINOGEN IN IN PATIENTS PATIENTS PATIENTS WITH
WITH
ESSENTIAL ESSENTIAL HYPERTENSION.
HYPERTENSION.
Jankowska Jankowska K. K. 1 2 2 2 2
, , Gluszek Gluszek J. J. , , Zaporowska-Stachowiak Zaporowska-Stachowiak Zaporowska-Stachowiak I. I. , , Niklas Niklas A AA.
A , , Bobkiewicz-K
Bobkiewicz-Kozlowska Bobkiewicz-K ozlowska T TT.
TT
1 Poznan University of Medical Sciences, Poznan, Poland
2 Poznan University of Medical Sciences, Department of Arterial Hypertension, Poznan, Poland
458. 458. PROPHYLACTIC PROPHYLACTIC EFFECT EFFECT OF OF LITHIUM LITHIUM IN IN BIPOLAR BIPOLAR DISORDER DISORDER RELATED RELATED TO TO POLYMORPHISMS
POLYMORPHISMS
OF OF 5HT2A 5HT2A AND AND 5HT2C 5HT2C SEROTONIN SEROTONIN RECEPTOR RECEPTOR GENES.
GENES.
Dmitrzak- Dmitrzak-Weglarz Dmitrzak- Dmitrzak- eglarz M., M., Slopien Slopien A AA.,
A A.,
., Suwalska Suwalska A AA.,
A ., Czerski Czerski P PP.,
P ., Leszczynska-Rodziewicz Leszczynska-Rodziewicz A AA.,
A A.,
., Rybakowski Rybakowski J., J., Hauser Hauser J.
J.
Poznan University of Medical Sciences, Department of Child and Adolescent Psychiatry, Poznan, Poland
459. 459. CYP3A4 CYP3A4 CYP3A4 AND AND AND 3A5 3A5 CATALYSED CATALYSED METABOLISM METABOLISM METABOLISM OF OF QUININE QUININE AND AND AND ALPRAZOLAM ALPRAZOLAM IN IN VITRO VITRO VITRO AND AND IN IN VIVO
VIVO
Miura Miura J. J. 1 1 1 1 2 1 2 1 , , , Aklillu Aklillu Aklillu E. E. , , Allqvist Allqvist A AA.
A , , Gustafsson Gustafsson LL. LL. , , Jande Jande M. M. , , Mirghani Mirghani RA RA. RA , , , Sayi Sayi Sayi J. J. , , W WWennerholm
WW
ennerholm A AA.
A , , W WWiden
W iden
J. J. J. 1 ,Bertilsson ,Bertilsson ,Bertilsson L.
L.
1 Laboratory medicine, Karolinska Institutet, Clinical Pharmacology, Stockholm, Sweden
2 Muhimbili University College of Health Sciences, Clinical Pharmacology, Dar Es Salaam, Tanzania
460. 460. APAI APAI POLYMORPHISM POLYMORPHISM OF OF VITAMIN VITAMIN VITAMIN D D RECEPTOR RECEPTOR GENE GENE GENE AND AND SUSCEPTIBILITY SUSCEPTIBILITY TO TO OSTEOPOROSIS
OSTEOPOROSIS
IN IN POLISH POLISH POSTMENOPAUSAL POSTMENOPAUSAL WOMEN WOMEN
WOMEN
Seremak-Mrozikiewicz Seremak-Mrozikiewicz A AA.,
A ., Drews Drews K., K., K KKurzawinska
K urzawinska G., G., Pienkowski Pienkowski WW
W. W
Poznan University of Medical Sciences, Department of Perinatology and Gynecology, Division of Perinatology and
Women's Diseases, Poznan, Poland

461. 461. 461. PVUII PVUII AND AND XBAI XBAI RESTRICTION RESTRICTION RESTRICTION POLYMORPHISMS POLYMORPHISMS OF OF OF ESTROGEN ESTROGEN ESTROGEN RECEPTOR RECEPTOR ALPHA ALPHA GENE
GENE
IN IN OSTEOPOROTIC OSTEOPOROTIC WOMEN
WOMEN
Drews Drews K., K., Seremak-Mrozikiewicz Seremak-Mrozikiewicz Seremak-Mrozikiewicz AA
A., AA
., K KKurzawinska
K urzawinska G.,Pienkowski G.,Pienkowski W WW.
W
Poznan University of Medical Sciences, Department of Perinatology and Gynecology, Division of Perinatology and
Women's Diseases, Poznan, Poland
462. 462. COX COX I I AND AND COX COX II II PROTEIN PROTEIN EXPRESSION EXPRESSION IN IN HUMAN HUMAN BREAST BREAST CANCER CANCER T47D T47D CELLS
CELLS
AND AND ITS ITS DERIVED DERIVED TAMOXIFEN TAMOXIFEN TAMOXIFEN RESISTANT RESISTANT RESISTANT SUBLINE
SUBLINE
Azizi Azizi E., E., F FFouladdel
F ouladdel S., S., Arbabi Arbabi S.
S.
Tehran University of Medical Sciences, Molecular Research Lab., Department of Pharmacology and Toxicology, Faculty
of Pharmacy and National Center of Excellence of Toxicology, Tehran, Iran
463. 463. INFLUENCE INFLUENCE OF OF ABCB1 ABCB1 AND AND SLCO1B3 SLCO1B3 HAPLOTYPES HAPLOTYPES ON ON ON DIGOXIN DIGOXIN PHARMACOKINETICS
PHARMACOKINETICS
Johne Johne A AA.,
A ., Gerloff Gerloff T TT.,
T ., W WWojewoda
W ojewoda A AA.,
A ., Wudel Wudel Wudel S., S., S., Bauer Bauer S., S., Mai Mai I., I., Goldammer Goldammer M., M., K KKopke
K opke K., K., Roots Roots I.
I.
Charite - Universitaetsmedizin Berlin, Institute of Clinical Pharmacology, Berlin, Germany
464. 464. IS IS CYP2D6 CYP2D6 OXIDATION OXIDATION GENOTYPE GENOTYPE A A RISK RISK FACTOR FACTOR IN IN THE THE DEVELOPMENT DEVELOPMENT OF OF ACUTE
ACUTE
MYELOBLASTIC MYELOBLASTIC LEUKEMIA?
LEUKEMIA?
Lapiñski Lapiñski L. L. 1 2 1 2 1 , , Ganczarski Ganczarski G. G. , , W WWiela-Hojenska
W Wiela-Hojenska
iela-Hojenska A AA.
A , , W WWolowiec
W olowiec D. D. , , Orzechowska-Juzwenko Orzechowska-Juzwenko K. K. ,
Glowacka Glowacka K. K. K. 1 1 1 2
, , , Hurkacz Hurkacz M. M. , , Niewinski Niewinski P PP.
P , , K KKuliczkowski
K uliczkowski K. K.
1 Department of Clinical Pharmacology, Wroc³aw Medical University, Wroc³aw, Poland
2 Department of Haematology, Wroc³aw Medical University, Wroc³aw, Poland
465. 465. THE THE INFLUENCE INFLUENCE OF OF OF ACUTE ACUTE MYELOBLASTIC MYELOBLASTIC LEUKEMIA LEUKEMIA CHEMOTHERAPY CHEMOTHERAPY CHEMOTHERAPY ON ON GENETIC GENETIC GENETIC OXIDATION
OXIDATION
AND AND ACETYLATION ACETYLATION PHENOTYPES
PHENOTYPES
Lapiñski Lapiñski L. L. 1 1 2 1 1 1 , , , W WWiela-Hojenska
W Wiela-Hojenska
iela-Hojenska A AA.
A , , W WWolowiec
W Wolowiec
olowiec D. D. D. , , , Ganczarski Ganczarski Ganczarski G. G. , , , Orzechowska-Juzwenko Orzechowska-Juzwenko Orzechowska-Juzwenko K. K. K. , , , Niewinski Niewinski P PP.
P , , G³o- G³o- G³o- G³o- G³o-
wacka wacka K. K. 1 1 1 1 1
, , Czarnik-Matusewicz Czarnik-Matusewicz Czarnik-Matusewicz M. M. M. , , , Hurkacz Hurkacz M. M. M. , , , K KKuliczkowski
K Kuliczkowski
uliczkowski K. K. , , Milejski Milejski Milejski P PP.
PP
1 Department of Clinical Pharmacology, Wroc³aw Medical University, Wroc³aw, Poland
2 Department of Haematology, Wroc³aw Medical University, Wroc³aw, Poland
466. 466. THE THE EFFECT EFFECT OF OF OF COCULTURE COCULTURE COCULTURE OF OF GRANULOSA GRANULOSA CELLS CELLS IN IN HAMS' HAMS' AND AND FOLLICULAR FOLLICULAR FLUID FLUID ON ON HUMAN
HUMAN
EMBROYS EMBROYS GROWTH GROWTH AND AND DEVELOPMENT
DEVELOPMENT
Sadeghipour Sadeghipour Roudsari Roudsari HR., HR., VV
Vasaghi VV
asaghi B.
B.
Tehran University of Medical Sciences, Tehran, Iran
467. 467. ETHNIC ETHNIC ETHNIC DIFFERENCES DIFFERENCES IN IN CYP2B6 CYP2B6 CYP2B6 ACTIVITY ACTIVITY AND AND INDUCTION INDUCTION BY BY RIFAMPICIN
RIFAMPICIN
Loboz Loboz K. K. 1 2 3 3 3 1
, , , Gross Gross Gross A AA.
A , , W WWilliams
W Williams
illiams K. K. , , Liauw Liauw W WW.
W , , Day Day R. R. , , Mclachlan Mclachlan A AA.
A
1 University of Sydney, Pharmacy, Sydney, Australia
2 GlaxoSmithKline, Clinical Pharmacology & Discovery Medicine, Sydney, Australia
3 St Vincent's Hospital & University of NSW, Clinical Trials Centre, Sydney, Australia

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