IBTS DIAG GDE 0001 - Irish Blood Transfusion Service

IBTS/DIAG/GDE/0001 Ver. 2 Page 36 of 4112.1.2. Ante-Natal Specimens for Antibody TitrationAntibody Titre Recommendation CommentAnti-K N/A Anti-K can cause HDN irrespectiveof titre. Recommend referral to aFoetal Medicine Assessment Unit.Repeat specimens recommendedevery 4 weeks to week 28gestation, then every 2 weeks todelivery. Check Partner’s Kk type.If Kell negative and paternity canbe confirmed, repeat specimenrecommended at 28 weeksgestation. If partner’s Kell type isK positive or cannot be determined,then refer the maternal specimenfor foetal K genotype and adviserepeat specimens for antibodytitration every 4 weeks to week 28gestation, then every 2 weeks todelivery is recommended.OtherClinicallySignificantAntibodies≤32≥32Antibody titres ≤32 are associatedwith a low risk of HDN. Checkantibody levels at 28-32 weeksgestation. Referral of paternalspecimen for antigen typing and /or maternal specimen for foetalgenotyping (if appropriate)Antibody titres ≥32 are consideredclinically significant for HDN.Referral to a Foetal MedicineAssessment Unit is advised.Referral of paternal specimen forantigen typing and /or maternalspecimen for foetal genotyping( if appropriate)Check cord DAT atdelivery and monitor infantfor evidence ofhaemolysis.Check cord DAT atdelivery and monitor infantfor evidence of haemolysisCheck cord DAT atdelivery and monitor infantfor signs of haemolysis