Bascom Palmer Angiogenesis - 2013 Brochure pdf

Angiogenesis,Exudation, andDegeneration 2013February 9, 2013Bascom PalmerEye InstituteMIAMI, FLORIDASponsored by theUniversity of Miami Miller School of Medicine

BASCOM PALMER EYE INSTITUTEAngiogenesis,Exudation,and Degeneration2013Bascom Palmer Eye Instituteinvites you to join us in February2013 for our tenth annualangiogenesis meeting. Thisunique and exciting symposiumentitled Angiogenesis,Exudation, and Degeneration 2013 will be held February9, 2013 at the Mandarin Oriental Hotel in Miami, Florida.The meeting will feature an exceptional gathering ofbasic scientists, clinicians, and healthcare experts, allfocused on understanding and treating neovascular andexudative diseases of the eye. The meeting will highlightthe revolutionary pharmacotherapies now in developmentand clinical practice for the management of neovascularAMD, macular edema, diabetic retinopathy, and retinopathyof prematurity with a special emphasis on the presentand future financial impact of these drugs on clinicalpractices and Medicare.Mandarin Oriental, Miami

COURSE CO-DIRECTORSPhilip J. Rosenfeld, MD, PhDProfessor of OphthalmologyBascom Palmer Eye InstituteUniversity of Miami Miller School of MedicineCourse Co-Director, Angiogenesis 2013Harry W. Flynn, Jr., MDProfessor of OphthalmologyThe J. Donald M. Gass DistinguishedChair in OphthalmologyBascom Palmer Eye InstituteUniversity of Miami Miller School of MedicineCourse Co-Director, Angiogenesis 2013Carmen A. Puliafito, MD, MBADean, Keck School of MedicineMay S. and John Hooval Dean’s Chair in MedicineProfessor of Ophthalmology and Health ManagementDoheny Eye InstituteUniversity of Southern CaliforniaCourse Co-Director, Angiogenesis 2013COURSE DESCRIPTIONAngiogenesis 2013 follows the tradition of excellenceestablished by the widely acclaimed Angiogenesisprograms between 2004 and 2012. Designed for retinalspecialists, general ophthalmologists and researchers, thecurrent program will review the latest therapies forexudative eye diseases and the use of these newtreatments in clinical practice. We will emphasize currentand future treatments for a broad spectrum of retinaldiseases with special emphasis on age-related maculardegeneration and diabetic retinopathy.COURSE OBJECTIVESUpon completion of this program, participants shouldbe able to:• Enhance patient care by evaluating the current global useof anti-VEGF drugs for exudative ocular diseases• Manage patients with anti-VEGF therapy through thepreferred dosing practices• Improve management skills by evaluating all the risksassociated with injections of anti-VEGF drugs• Analyze results of clinical trials in exudative maculardiseases and apply to clinical practice• Evaluate the benefits and limitations of combinationtherapies for exudative diseases• Evaluate the benefits and limitations of different imagingstrategies for age-related macular degeneration• Enhance patient care by analyzing the genetic basis fordifferent macular and retinal degenerative conditions• Analyze the rationale for emerging treatments for differentmacular and retinal degenerative conditions

PROGRAMSubject to changeSATURDAY, FEBRUARY 9, 20137:00 am Registration and Continental Breakfast7:55 Welcome and OverviewPhilip J. Rosenfeld, MD, PhD, Harry W. Flynn, Jr., MD,and Carmen A. Puliafito, MD, MBASESSION I – Dry Age-Related Macular Degeneration8:00 Evolution of Epidemiology, Genetics and RiskPrediction Models for AMDJohanna M. Seddon, MD, SCM8:10 Role of Inflammation in AMD:Definition and New PathwaysVictor L. Perez, MD8:20 Toward a Refined Understanding of the Biology &Genetics of AMD: Therapeutic & Diagnostic ImplicationsGregory S. Hageman, PhD8:30 Clinical Classification of Age-Related MacularDegenerationFrederick L. Ferris, III, MD8:40 Dietary and Nutrition Supplementation and Eye Health:The Basic Science Behind AREDS2Paul S. Bernstein, MD, PhD8:50 Update of Geographic Atrophy in AREDSEmily Y. Chew, MD9:00 Choroid - Retinal Pigment Epithelium – PhotoreceptorInteractions in Age-Related Macular Degenerationin Humans – Role in Determining ProgressionKarl G. Csaky, MD, PhD9:10 Can SD-OCT Imaging Predict Progressionof Geographic Atrophy?Renata Portella Nunes, MD9:20 Local Risk Factors for Progression of Drusenoid Lesionsto Geographic AtrophySrinivas R. Sadda, MD9:30 Pearls from the COMPLETE StudyZohar Yehoshua, MD, MHA9:40 Anti-C5 Aptamer for Dry AMDBaruch D. Kuppermann, MD, PhD9:50 Complement Inhibition Using Gene Therapy for AMDJay S. Duker, MD10:00 Targeting Amyloid Beta in Dry AMDScott W. Cousins, MD

10:10 Visual Cycle Modulation in Dry AMDPhilip J. Rosenfeld, MD, PhD10:20 Valproic Acid for AMD and Retinal DegenerationsShalesh Kaushal, MD, PhD10:30 Novel Therapeutic Targeting for Geographic AtrophyJayakrishna Ambati, MD10:40 The TOGA Study: A Phase III Study Evaluating the(T)reatment with (O)RACEA (doxycycline) in (G)eographic(A)trophyElias Reichel, MD10:50 Using Stem Cells to Model and Treat AMDKang Zhang, MD, PhD11:00 h-ESC Derived RPE Transplantation for Stargardt Diseaseand Atrophic AMD: Safety UpdateSteven D. Schwartz, MD11:10 Update on Embryonic Stem Cell Therapies for AMDDavid R. Hinton, MD11:20 iPS-Derived Retinal Cell TherapyAl Reaves, PhD11:30 Endoscopic Delivery of Cell Based Therapy for Atrophic AMDAllen C. Ho, MD11:40 The Oil Spill in Bruch’s Membrane: Setting the Stage forChoroidal NeovascularizationChristine A. Curcio, PhD, FARVO11:50 Inflamm-Aging and Neovascular AMDRajendra S. Apte, MD, PhD12:00 AZOOR RevisitedLawrence A. Yannuzzi, MD12:10 pm LunchSESSION II: Wet Age-Related Macular Degeneration1:00 The Roles of Angiography and Optical Coherence Tomographyin the Management of Retinal and Choroidal DiseasesAlexander J. Brucker, MD1:10 RAP lesionsDavid J. Wilson, MD1:20 The CSC, Type 1 Neovascularization, and PCV ConnectionK. Bailey Freund, MD1:30 Current Anti-VEGF Treatment Algorithms for Wet AMDCarl D. Regillo, MD, FACS

1:40 Real-world Utilization of Anti-VEGF Therapiesin Age-Related Macular DegenerationSzilárd Kiss, MD1:50 Non-infectious Endophthalmitis After Intravitreal InjectionFenghua Wang, MD2:00 IVAN Trial UpdateBarnaby Reeves, DPhil2:10 Top 5 Findings from the Comparison ofAMD Treatment TrialsDaniel F. Martin, MD2:20 VEGF Antagonism–Can You Have Too Much of aGood Thing?Martin Friedlander, MD, PhD2:30 High Dose Ranibizumab for Wet AMDAnne E. Fung, MD2:40 The Impact of Neutralizing Antibodies Against RanibizumabRobert L. Avery, MD2:50 Update on Aflibercept for Wet AMDJeffrey S. Heier, MD3:00 Comparison of Avastin/Lucentis with Eylea in Clinical PracticeJason S. Slakter, MD3:10 Anti-VEGF Therapy in ChinaXiaodong Sun, MD3:20 Anti-VEGF DARPin for Wet AMDDavid M. Brown, MD, FACS3:30 PDGF Inhibition in Wet AMD: Part 1Pravin U. Dugel, MD3:40 PDGF Inhibition in Wet AMD: Part 2Peter K. Kaiser, MD3:50 Radiation Therapy for Wet AMDDarius M. Moshfeghi, MD4:00 Refillable Drug Delivery Implant Providing SustainedRelease Anti-VEGF Therapy in Wet AMDAnat Loewenstein, MD4:10 Sustained VEGF Inhibition with Encapsulated Cell TechnologyGlenn J. Jaffe, MD4:20 Gene Transfer Trials for Wet AMD: U.S. ExperiencePeter A. Campochiaro, MD4:30 Gene Transfer Trials for Wet AMD: Australian ExperienceThomas W. Chalberg, PhD

4:40 Anti-Sphingosine-1-Phosphate Monoclonal Antibodyfor Wet AMDGlenn L. Stoller, MD, FACS4:50 Topical Squalamine for Wet AMDLawrence J. Singerman, MD, FACS5:00 Targeting Tissue Factor in Wet AMDChristine R. Gonzales, MD5:10 Integrin Inhibition in Wet AMDStephan Michels, MD, MBA5:20 Enzymatic Manipulation of the Vitreoretinal Interface:Implications for Age-related Macular DegenerationAndrew A. Moshfeghi, MD, MBASESSION III – Central SerousChorioretinopathy/Retinal Vascular Diseases5:30 Mineralocorticoid Receptor Antagonists forCentral Serous ChorioretinopathyFrancine Behar-Cohen, MD PhD5:40 Anti-VEGF Therapy in Ocular OncologyJ. William Harbour, MD5:50 Current and Future Treatment Options forRetinal Vein OcclusionsDavid S. Boyer, MD6:00 Early Neurosensory Retinal Changes in Diabetes MellitusMichel E. Farah, MD6:10 A Novel Treatment for Diabetic NeurovasculopathyMichael T. Trese, MD6:20 DRCR Network UpdateHarry W. Flynn, Jr., MD6:30 Aflibercept for Diabetic Macular EdemaDiana V. Do, MD6:40 Drugs in Development for Diabetic Macular EdemaQuan Dong Nguyen, MD, MSc6:50 Questions and Answers7:00 Adjourn/Cocktail Reception

SPEAKERSGUEST FACULTYJayakrishna Ambati, MDProfessor and Vice ChairDr. E Vernon Smith & Eloise C. SmithEndowed ChairDepartment of Ophthalmology & Visual SciencesUniversity of KentuckyLexington, KYRajendra S. Apte, MD, PhDAssociate Professor of Ophthalmology andVisual ScienceAssociate Professor of Developmental BiologyDirector of EducationWashington University School of MedicineSt. Louis, MORobert L. Avery, MDFounder, California Retina ConsultantsCo-founder, California Retina ResearchFoundationUCSB at the Neuroscience Research InstituteSanta Barbara, CAFrancine Behar-Cohen, MD, PhDProfessor of OphthalmologyHôtel-Dieu Hospital of ParisParis Descartes UniversityDirector, INSERM UMRS872Physiopathology of Ocular Diseases:Therapeutic ImplicationsParis, FrancePaul S. Bernstein, MD, PhDMary Boesche Professor of Ophthalmologyand Visual Sciences, Moran Eye CenterUniversity of Utah School of MedicineSalt Lake City, UTDavid S. Boyer, MDClinical Professor of OphthalmologyKeck School of MedicineDoheny Eye InstituteUniversity of Southern CaliforniaRetina-Vitreous Associates Medical GroupLos Angeles, CADavid M. Brown, MD, FACSClinical Associate Professor of OphthalmologyWeill Cornell Medical CollegeThe Methodist HospitalRetina Consultants of HoustonHouston, TXAlexander J. Brucker, MDProfessor of OphthalmologyPerelman School of MedicineUniversity of PennsylvaniaPhiladelphia, PAPeter A. Campochiaro, MDGeorge S. and Dolores Dore EcclesProfessor of Ophthalmology and NeuroscienceWilmer Eye InstituteThe Johns Hopkins University School of MedicineBaltimore, MDThomas W. Chalberg, PhDPresident and Chief Executive OfficerAvalanche Biotechnologies, Inc.San Francisco, CAEmily Y. Chew, MDDeputy Director, Division ofEpidemiology & Clinical ApplicationsChief of Clinical TrialsNational Eye InstituteBethesda, MDScott W. Cousins, MDRobert Machemer, MD, Professor ofOphthalmology and ImmunologyDirector, Duke Center for Macular DiseasesDuke Eye Center, Duke UniversityDurham, NCKarl G. Csaky, MD, PhDT. Boone Pickens Senior ScientistHead, Harrington Molecular LaboratoryRetina Foundation of the SouthwestDallas, TXChristine A. Curcio, PhD, FARVOProfessor of OphthalmologyDirector, Age-related MaculopathyHistopathology LaboratoryUniversity of Alabama School of MedicineEyeSight Foundation Vision Research LabsBirmingham, ALDiana V. Do, MDAssociate Professor of OphthalmologyWilmer Eye InstituteThe Johns Hopkins University School of MedicineBaltimore, MDPravin U. Dugel, MDClinical Associate Professor of OphthalmologyKeck School of MedicineDoheny Eye InstituteUniversity of Southern CaliforniaLos Angeles, CAManaging PartnerRetina Consultants of ArizonaPhoenix, AZJay S. Duker, MDProfessor and ChairmanDirector, New England Eye CenterTufts Medical CenterTufts University School of MedicineBoston, MAMichel E. Farah, MDProfessor of OphthalmologyVision InstitutePaulista School of MedicineSão Paulo Federal UniversitySão Paulo, BrazilFrederick L. Ferris, III, MDDirector, Division of Epidemiology& Clinical ApplicationsClinical Director, National Eye InstituteBethesda, MDK. Bailey Freund, MDClinical Associate Professor of OphthalmologyNew York University School of MedicineVitreous Retina Macula Consultants of NYNew York, NYMartin Friedlander, MD, PhDProfessor, Department of Cell BiologyDivision of Ophthalmology, Department of SurgeryThe Scripps Research InstituteScripps ClinicLa Jolla, CAAnne E. Fung, MDCalifornia Pacific Medical CenterPacific Eye AssociatesSan Francisco, CAChristine R. Gonzales, MDRetina & Vitreous CenterAshland, ORGregory S. Hageman, PhDJohn A. Moran Presidential ProfessorExecutive Director, Moran Center forTranslational MedicineJohn A. Moran Eye CenterUniversity of UtahSalt Lake City, UTJeffrey S. Heier, MDDirector, Vitreo-Retina ServiceOphthalmic Consultants of BostonBoston, MADavid R. Hinton, MDProfessor of Pathology and OphthalmologyGavin S. Herbert Professor of Retinal ResearchKeck School of MedicineDoheny Eye InstituteUniversity of Southern CaliforniaLos Angeles, CAAllen C. Ho, MDProfessor of OphthalmologyWills Eye InstituteThomas Jefferson UniversityMid Atlantic RetinaPhiladelphia, PA

Glenn J. Jaffe, MDProfessor of OphthalmologyDuke Eye CenterDuke University School of MedicineDurham, NCPeter K. Kaiser, MDProfessor of OphthalmologyChaney Family Endowed Chair forOphthalmology ResearchCole Eye Institute, Cleveland ClinicCleveland, OHShalesh Kaushal, MD, PhDAssociate ProfessorChairman, Department of OphthalmologyUniversity of Massachusetts Medical SchoolWorcester, MASzilárd Kiss, MDAssistant Professor of OphthalmologyDirector of Clinical ResearchWeill Cornell Medical CollegeNewYork-Presbyterian HospitalNew York, NYBaruch D. Kuppermann, MD, PhDProfessor of Ophthalmology and BiomedicalEngineeringVice Chair, Clinical ResearchThe Gavin Herbert Eye InstituteUniversity of California, IrvineIrvine, CAAnat Loewenstein, MDChairman, Department of OphthalmologySydney A. Fox Chair in OphthalmologyTel Aviv Medical Center, Tel Aviv UniversityTel Aviv, IsraelDaniel F. Martin, MDBarbara and A. Malachi Mixon III InstituteChair in OphthalmologyChairman, Cole Eye Institute, Cleveland ClinicCleveland, OHStephan Michels, MD, MBAAssociate Professor of OphthalmologyHead, Medical Retina, Triemli Hospital ZurichZurich, SwitzerlandDarius M. Moshfeghi, MDAssociate ProfessorByers Eye Institute at StanfordStanford University School of MedicinePalo Alto, CAQuan Dong Nguyen, MD, MScAssociate Professor of OphthalmologyWilmer Eye InstituteJohn Hopkins University School of MedicineBaltimore, MDAl Reaves, PhDSenior Vice President, Regulatory AffairsRetina Institute Japan KKAlpharetta, GABarnaby Reeves, DPhilProfessor of Health Services ResearchClinical Trials & Evaluation UnitBristol Royal InfirmaryUniversity of BristolBristol, United KingdomCarl D. Regillo, MD, FACSProfessor of OphthalmologyDirector, Retina Service, Wills Eye InstituteThomas Jefferson UniversityPhiladelphia, PAElias Reichel, MDProfessor and Vice Chair of OphthalmologyNew England Eye CenterTufts Medical CenterTufts University School of MedicineBoston, MASrinivas R. Sadda, MDAssociate Professor of OphthalmologyKeck School of MedicineDoheny Eye InstituteUniversity of Southern CaliforniaLos Angeles, CASteven D. Schwartz, MDAhmanson Professor of OphthalmologyJules Stein Eye InstituteDavid Geffen School of Medicine, UCLALos Angeles, CAJohanna M. Seddon, MD, SCMProfessor of OphthalmologyDirector, Ophthalmic Epidemiology andGenetics Service, New England Eye CenterTufts Medical CenterTufts University School of MedicineBoston, MALawrence J. Singerman, MD, FACSClinical Professor of OphthalmologyCase Western Reserve UniversityRetina Associates of ClevelandBeachwood, OHJason S. Slakter, MDClinical Professor of OphthalmologyNew York University School of MedicinePartner, Vitreous-Retina Macula Consultantsof New YorkNew York, NYGlenn L. Stoller, MD, FACSOphthalmic Consultants of Long IslandRoslyn, NYXiadong Sun, MDProfessor and Chief Executive Vice ChairShanghai Eye Research InstituteShanghai First People’s HospitalShanghai Jiao Tong UniversityShanghai, ChinaMichael T. Trese, MDClinical Professor of OphthalmologyChief of Pediatric & Adult Vitreoretinal SurgeryWilliam Beaumont HospitalOakland University William Beaumont Schoolof MedicineRoyal Oak, MIFenghua Wang, MDAssociate ProfessorShanghai First People’s HospitalShanghai Jiao Tong UniversityShanghai, ChinaDavid J. Wilson, MDProfessor and Thiele-Petti ChairDirector, Casey Eye InstituteOregon Health and Science UniversityPortland, ORLawrence A. Yannuzzi, MDProfessor of Clinical OphthalmologyEdward S. Harkness Eye InstituteManhattan Eye, Ear, Nose & Throat HospitalColumbia University College of Physiciansand SurgeonsFounder and President, VitreousRetina Macula Consultants of New Yorkand the Macula Foundation, Inc.New York, NYKang Zhang, MD, PhDProfessor of Ophthalmology and Human GeneticsDirector, UCSD Institute for Genomic MedicineUniversity of California San DiegoShiley Eye CenterLa Jolla, CABASCOM PALMER EYEINSTITUTE FACULTYJ. William Harbour, MDProfessor of OphthalmologyAndrew A. Moshfeghi, MD, MBAAssociate Professor of OphthalmologyVictor L. Perez, MDAssociate Professor of OphthalmologyRenata Portella Nunes, MDPostdoctoral AssociateZohar Yehoshua, MD, MHAAssistant Professor of Clinical Ophthalmology

INFORMATIONBascom Palmer Eye InstituteAngiogenesis, Exudation, andDegeneration 2013DATESaturday, February 9, 2013: 7:55 am to 7:00 pmLOCATIONMandarin Oriental, Miami500 Brickell Key Drive, Miami, FL 33131Reservations: (800) 526-6566 Direct: (305) 913-8288Mandarin Oriental, Miami is one of America’s finest hotelsand recently awarded the AAA Five Diamond Award. Ideallylocated on prestigious Brickell Key, its deluxe, waterfrontlocation perfectly befits the opulence you’ll find within. Therooms are luxurious, the award-winning restaurants are someof the finest in Miami and the spa is one of the most beautifulin the world. The hotel’s extensive leisure facilities make it theperfect choice for a holiday in Miami.HOTEL RESERVATIONSFor hotel information and reservations, please call(305) 913-8288 or (800) 526-6566.The special hotel rate for conference attendees is $379 pernight for single or double plus tax. Mandarin Oriental, Miamiwill extend the special group rate for three days prior andthree days after the main program dates, subject to availability.Check-in time is 3:00 pm; Check-out time is 12:00 noon.We suggest you make your hotel reservations as soon aspossible as the winter months are the height of SouthFlorida’s tourist season. Bascom Palmer’s preferred roomrate will be released after January 8, 2013. Reservations anddeposits received after that time are subject to current ratesand availability. Please contact the Mandarin Oriental Miamifor hotel cancellation policies. For additional information visit:www.mandarinoriental.com/miamiCONFERENCE FEESRegistration rate is $425.Conference fees include course materials, opening reception,continental breakfast, lunch and refreshment breaks.CANCELLATION POLICYConference tuition, less $100 cancellation fee, is refundable ifnotice is received on or before January 8, 2013.Cancellations received on or after January 9, 2013 will not berefunded.

MEETINGREGISTRATIONFORMBascom Palmer Eye InstituteAngiogenesis, Exudation, andDegeneration 2013Saturday, February 9, 2013Registration is limited, so please register early.Last Name / First Name (as you want it to appear on name badge) / DegreeLast Four Digits of Social Security Number (for record keeping purposes only)Specialty / Sub-specialtyAffiliated InstitutionAddress (Check box if new address)City/StateCountry / Zip or Postal CodeOffice phoneOffice faxEmailREGISTRATION: $425Enclosed is my check made payable toBascom Palmer Eye Institute–Angiogenesis 2013Please bill my credit card:Mastercard Visa American ExpressCard numberSecurity codeExpiration dateName on cardSignatureBy fax: Please complete this registration form with your credit cardpayment and fax to (305) 326-6518. By mail: Please complete thisregistration form and return with your check or credit card payment to:Bascom Palmer Eye InstituteContinuing Medical Education Department1120 NW 14th Street, Suite 1558Miami, FL 33136(Attn: Karen Davila)

ACCREDITATIONUniversity of Miami Leonard M. Miller School of Medicine isaccredited by the Accreditation Council for Continuing MedicalEducation to provide continuing medical education forphysicians.CREDIT DESIGNATIONThe University of Miami Leonard M. Miller School of Medicinedesignates this live activity for a maximum of 10 AMA PRACategory 1 Credits. Physicians should claim only the creditcommensurate with the extent of their participation in the activity.DISCLOSURE AND CONFLICT OF INTEREST RESOLUTIONAll conflicts of interest of any individual in a position to controlthe content of this CME activity will be identified and resolvedprior to this educational activity being provided. Disclosureabout provider and faculty relationships, or the lack thereof, willbe provided to learners.SERVICES FOR THE DISABLEDIf special arrangements are required for an individual with adisability to attend this conference, please contact Karen Davilaat (305) 326-6110 on or before January 15, 2013.REGISTRATION Space is limited. Please register early.To register by mail: Please complete the registration form andreturn with your check or credit card payment to:Bascom Palmer Eye InstituteDepartment of Continuing Medical Education1120 NW 14th Street, Suite 1558, Miami, FL 33136(Att: Karen Davila)To register by fax: Please complete the registration form andreturn with your credit card payment to (305) 326-6518.For more information contact:Bascom Palmer Eye InstituteDepartment of Continuing Medical Educationat (305) 326-6110 / Email: bascompalmercme@miami.eduwww.bascompalmer.org