Dr Hodjattallah Rabbani - Avicenna Research Institute

Cancer center KarolinskaCourse: Neurotransmiters and their receptors-molecular biological techniquesCourse no: 1490 NOVUM, Hudinge 15 and 19 Oct 2001 3 hoursOrganizing Seminar in cDNA Microarray (Affymetrix GeneChip) (Educational)Cancer center KarolinskaMarch 12, 2001 1.5 HoursFrom Tumor Immunology to Immune and Gene Therapy of CancerCancer center Karolinska Course #1594 October 29, 2002 4.0 HoursInvited seminar, Dept. Hematology, Huddinge Hospital, 2003 2 hoursCourse: Neurotransmiters and their receptors-molecular biological techniquesCourse no: 1490, October 20-24, 2003 NOVUM, Huddinge 3 hoursCourse No: 1784 CCK, KS 2004 28 hoursOrganized course: As course organizer and lecturerFrom gene to protein (KI Forskarutbildningskurs, 1784)Feb. 2-Feb. 13, 2004, two weeks, two pointsNov. 1-Nov. 10, 2004, two weeks, two pointsSupervising students(Examensarbete)CurrentlyCo-supervisingMalin Johansson 1991 20 poängParinaz kadkhodayan 1994 20 poängJelve Nejaty 1994 20 poängAnnika pontén 1995 20 poängMalahat mousavy 1996 20 poängRoberto Danova 1997 4 poängJohan Lengqvist 2000 20 poängAmir-Osman Abdalla (Registered)Eva Mikaelsson (Registered)Ph.D studentsSupervisingAmir Hossein Danesh Manesh (registered as Ph.D student)Awards receivedDiploma as number one in introducing a cancer vaccine strategy together withProf. Håkan Mellstedt and Anders Österborg (whole group)Venture Cup 99/00,Stockholm, Sweden

Other activities:Responsible for establishing and maintenance of the following core facilities atCancerCenter Karolinska1-ELISA system2-ELISPOT system3- Real-Time PCR4- Establishing the Affymetrix GeneChip Array system (CCK, KS)List of submitted abstracts:1- L. Hammarström, H. Rabbani, A. Bottaro, and CIE SmithThe Influence of Gene Duplications in the Human IGH Locus on Serum Levels ofImmunoglobulins.11 th European Immunology Meeting, June 10-12, 1991, Helsinki, Finland2- H. Rabbani, C. I. E. Smith and L. Hammarström,Deletions and Duplications in the Human Immunoglobulin Heavy Chain Constant Locus8 th International Congress of Immunology, Budapest, Hungary, 1992 (oral presentation)3- H. Rabbani, C. I. E. Smith and L. Hammarström,Analysis of the Human Ig Heavy Chain Constant Locus by PFGE in Different Ethnic GroupsThe 9 th International congress of immunology”, SanFrancisco, USA, 1995 (oralpresentation)4- Pan Q, Rabbani H, Hammarström LSwitch Region Polymorphism in Patients With IgG3 Subclass DeficiencyVII Meeting of the European Society of Immunodeficiencies, ESIDJune 6-9, 1996, Göteborg, Sweden (Poster)5- Hodjattallah Rabbani, Qiang Pan, Naomi Kondo, C. I. Edvard Smith andLennart Hammarström.Deletion, Duplication, and Triplication in the Human IGHC Locus in Different EthnicGroupsVII Meeting of the European Society of Immunodeficiencies, ESIDJune 6-9, 1996, Göteborg, Sweden (Poster and oral presentation)6- Parviz Kokhaei, Mohammad-Reza Rezvany, Anders Österborg, Hodjattallah Rabbani,and Håkan Mellstedt.Uptake of Apoptotic Tumor Cell by Autologous Dendritic Cells, A Tool for Immunotherapy in B CellMalignancies.11 th International Congress of Immunology, Stockholm, Sweden, 20017- Fariba Seyed-Mozaffari, Shahryar Kiaii, Anders Österborg, Hodjattallah Rabbani, andHåkan MellstedtAnalysis of T Cell Function in Patients With Chronic Lymphocytic Leukemia.11 th International Congress of Immunology, Stockholm, Sweden, 20018- Hodjattallah Rabbani, Fariba Seyed-Mozaffari, Katja Markovic, Jan-Erik Frödin, andHåkan Mellstedt.Immunization of Colorectal Carcinoma Patients With Avipox Vector, Expressing The Full-Length Gene of The Ga733/Epcam/Ksa Antigen.

11 th International Congress of Immunology, Stockholm, Sweden, 2001 (Poster)9- H. Mellstedt, L. Henriksson, A. O. Abdalla, H. Rabbani, A. ÖsterborgCombination of the Adjuvant Cytokines GM-CSF and IL-12 With the Idiotype VaccineInduces a Strong T Cell Immunity and Clinical Effects Might be Obtained.8 th International Myeloma Workshop, May 4-8, 2001, Banff, Canada10- Shahryar Kiaii, Mahmood Jeddi-Tehrani, Anders Österborg, Håkan Mellstedt, andHodjattallah RabbaniUtilizing Ki67 Gene Expression for Monitoring T Cell Activation in Vaccination StudiesThe Society for Biological Therapy's 16 th Annual Meeting, November 9-11, 2001 in NIH,Bethesda, USA11- Hodjattallah Rabbani, Eva Mikaelsson, Amir Hossein Daneshmanesh, Alfred Lüppert,Mahmood Jeddi- Tehrani, Mohammad-Reza Rezvany, Ramazan Ali Sharifian, Reza Safaie,Azam Roohi, Anders Österborg, Fazel Shokri, and Håkan MellstedtFibromodulin, A Novel Tumor-Associated Antigen Exclusively Expressed in Tumor B-CellsFrom all Patients with Chronic Lymphocytic Leukemia8 th Congress of the European Hematology Association, 12-15 June, 2003, Lyon, France12- Eva Mikaelsson, Mahmood Jeddi- Tehrani , Anders Österborg, Fazel Shokri,Hodjattallah Rabbani, Håkan MellstedtFibromodulin, A Novel Tumor-Associated Antigen Exclusively Expressed In Tumor B-CellsFrom Patients With Chronic Lymphocytic LeukemiaiwCLL X International Workshop on CLL. Palazzo Dei Congressi Stresa, Lake Maggiore,Italy10-12 October 2003

Papers published in scientific journals1-371. Olsson PG, Rabbani H, Hammarstrom L, Smith CI. Novel human immunoglobulin heavychain constant region gene deletion haplotypes characterized by pulsed-field electrophoresis.Clin Exp Immunol. 1993;94:84-902. Rabbani H, Bottaro A, Carbonara AO, Brusco A, Cariota U, Olsson PG, Smith CI,Hammarstrom L. The influence of gene duplications in the human immunoglobulin heavychain constant locus on serum levels of immunoglobulin. Immunodeficiency. 1993;4:237-2413. Rabbani H, de Boer M, Ahlin A, Sundin U, Elinder G, Hammarstrom L, Palmblad J,Smith CI, Roos D. A 40-base-pair duplication in the gp91-phox gene leading to X-linkedchronic granulomatous disease. Eur J Haematol. 1993;51:218-2224. Smith CI, Islam KB, Vorechovsky I, Olerup O, Wallin E, Rabbani H, Baskin B,Hammarstrom L. X-linked agammaglobulinemia and other immunoglobulin deficiencies.Immunol Rev. 1994;138:159-1835. Ahlin A, De Boer M, Roos D, Leusen J, Smith CI, Sundin U, Rabbani H, Palmblad J,Elinder G. Prevalence, genetics and clinical presentation of chronic granulomatous disease inSweden. Acta Paediatr. 1995;84:1386-13946. Islam KB, Rabbani H, Larsson C, Sanders R, Smith CI. Molecular cloning,characterization, and chromosomal localization of a human lymphoid tyrosine kinase relatedto murine Blk. J Immunol. 1995;154:1265-12727. Rabbani H, Kondo N, Smith CI, Hammarstrom L. The influence of gene deletions andduplications within the IGHC locus on serum immunoglobulin subclass levels. Clin ImmunolImmunopathol. 1995;76:S214-2188. Truedsson L, Baskin B, Pan Q, Rabbani H, Vorechovsky I, Smith CI, Hammarstrom L.Genetics of IgA deficiency. Apmis. 1995;103:833-8429. Rabbani H, Pan Q, Kondo N, Smith CI, Hammarstrom L. Duplications and deletions ofthe human IGHC locus: evolutionary implications. Immunogenetics. 1996;45:136-14110. Brown WR, Rabbani H, Butler JE, Hammarstrom L. Characterization of the bovine Calpha gene. Immunology. 1997;91:1-611. Mousavi M, Rabbani H, Hammarstrom L. Characterization of the bovine epsilon gene.Immunology. 1997;92:369-37312. Pan Q, Rabbani H, Mills FC, Severinson E, Hammarstrom L. Allotype-associatedvariation in the human gamma3 switch region as a basis for differences in IgG3 production. JImmunol. 1997;158:5849-585913. Rabbani H, Brown WR, Butler JE, Hammarstrom L. Polymorphism of the IGHG3 genein cattle. Immunogenetics. 1997;46:326-331

14. Luo L, Lu FM, Hart S, Foroni L, Rabbani H, Hammarstrom L, Yuille MR, Catovsky D,Webster AD, Vorechovsky I. Ataxia-telangiectasia and T-cell leukemias: no evidence forsomatic ATM mutation in sporadic T-ALL or for hypermethylation of the ATM-NPAT/E14bidirectional promoter in T-PLL. Cancer Res. 1998;58:2293-229715. Mousavi M, Rabbani H, Pilstrom L, Hammarstrom L. Characterization of the gene forthe membrane and secretory form of the IgM heavy-chain constant region gene (C mu) of thecow (Bos taurus). Immunology. 1998;93:581-58816. Pan Q, Rabbani H, Hammarstrom L. Characterization of human gamma 4 switch regionpolymorphisms suggests a meiotic recombinational hot spot within the Ig locus: influence ofS region length on IgG4 production. J Immunol. 1998;161:3520-352617. Rezvany MR, Jeddi-Tehrani M, Rabbani H, Ruden U, Hammarstrom L, Osterborg A,Wigzell H, Mellstedt H. Autologous T lymphocytes recognize the tumour-derivedimmunoglobulin VH-CDR3 region in patients with B-cell chronic lymphocytic leukaemia. BrJ Haematol. 2000;111:230-23818. Rezvany MR, Jeddi-Tehrani M, Rabbani H, Lewin N, Avila-Carino J, Osterborg A,Wigzell H, Mellstedt H. Autologous T lymphocytes may specifically recognize leukaemic Bcells in patients with chronic lymphocytic leukaemia. Br J Haematol. 2000;111:608-61719. Zhao Y, Rabbani H, Shimizu A, Hammarstrom L. Mapping of the chickenimmunoglobulin heavy-chain constant region gene locus reveals an inverted alpha geneupstream of a condensed upsilon gene. Immunology. 2000;101:348-35320. Brenden N, Rabbani H, Abedi-Valugerdi M. Analysis of mercury-induced immuneactivation in nonobese diabetic (NOD) mice. Clin Exp Immunol. 2001;125:202-21021. Rezvany MR, Jeddi-Tehrani M, Biberfeld P, Soderlund J, Mellstedt H, Osterborg A,Rabbani H. Dendritic cells in patients with non-progressive B-chronic lymphocyticleukaemia have a normal functional capability but abnormal cytokine pattern. Br J Haematol.2001;115:263-27122. Islam TC, Lindvall J, Wennborg A, Branden LJ, Rabbani H, Smith CI. Expressionprofiling in transformed human B cells: influence of Btk mutations and comparison to B celllymphomas using filter and oligonucleotide arrays. Eur J Immunol. 2002;32:982-99323. Malmberg KJ, Levitsky V, Norell H, de Matos CT, Carlsten M, Schedvins K, RabbaniH, Moretta A, Soderstrom K, Levitskaya J, Kiessling R. IFN-gamma protects short-termovarian carcinoma cell lines from CTL lysis via a CD94/NKG2A-dependent mechanism. JClin Invest. 2002;110:1515-152324. Mellin H, Dahlgren L, Munck-Wikland E, Lindholm J, Rabbani H, Kalantari M,Dalianis T. Human papillomavirus type 16 is episomal and a high viral load may becorrelated to better prognosis in tonsillar cancer. Int J Cancer. 2002;102:152-15825. Roether S, Rabbani H, Mellstedt H, Abedi-Valugerdi M. Spontaneous downregulationof antibody/autoantibody synthesis in susceptible mice upon chronic exposure to mercuricchloride is not owing to a general immunosuppression. Scand J Immunol. 2002;55:493-502

37- Chromek, M. Stankowska, D. Dadfar, E. Kaca, W. Rabbani, H. Brauner, A.Interleukin-8 Response In Cells From The Human Urinary Tract Induced ByLipopolysaccharides Of Proteus Mirabilis O3 And O18, J Urol, 2005, 173, 4, 1381-138438- Farah Idali, Maria Wikén 1 Jan Wahlström 1 Håkan Mellstedt 3 Anders Eklund,Hodjattallah Rabbani, and Johan Grunewald. Reduced Th1 response in the lungs of HLA-DR17 positive patients with pulmonary sarcoidosis. Eur Respir J. 2006 Mar;27(3):451-9.39. Rezvany MR, Jeddi-Tehrani M, Karlsson C, Lundin J, Rabbani H, Osterborg A,Mellstedt H. Reconstitution of the T-cell repertoire following treatment with alemtuzumab(anti-CD52 monoclonal antibody) in patients with B-cell chronic lymphocytic leukaemia.40- Amir H. Danesh-Manesh, Eva Mikaelsson, Mahmood Jeddi- Tehrani, Ali Ahmad Bayat,Roya Ghods, Mahyar Ostadkarampour, Mehdi Akhondi, Svetlana Lagercrantz, CatharinaLarsson, Anders Österborg, Fazel Shokri, Håkan Mellstedt, and Hodjattallah Rabbani . TheReceptor Tyrosine Kinase (RTK) Ror1 is Specifically Expressed and Auto-phosphorylated inB Chronic Lymphocytic Leukemia (B-CLL)- a Novel Structure for Targeted Therapy, 2006,Submitted to Blood!