New Products - Dunn Labortechnik GmbH

New ProductsMalaria (Plasmodium Species)MAb to Plasmodium LactateDehydrogenase (pLDH)Cat. No. C66509MMAb to Plasmodium HRP-2Cat. No. C01658MCat. No. C01659MCat. No. C01660MCat. No. C01661MP. falciparum HRP-2, RecombinantCat. No. R01478P. vivax CSP, RecombinantCat. No. R01440P. vivax MSP-1, RecombinantCat. No. R01439Immunogen: Recombinant pLDH fromPlasmodium knowlesiImmunogen: Recombinant PlasmodiumfalciparumFull-length HRP-2 sequence – contains atruncated maltose binding fusion partner353 amino acids – contains a GST fusionpartner108 amino acids – contains a truncatedmaltose binding protein partnerAbout MalariaMalaria is one of the oldest and most frequently occurring infectious diseases in humans. It is causedby a single-cell parasite called Plasmodium which is transmitted through the bite of an infected femalemosquito. Once infected, symptoms appear between 10-15 days and usually include fever,headache, and vomiting. If not treated, malaria can quickly become life-threatening by disrupting theblood supply to vital organs.Early diagnosis of malaria followed by effective and timely treatment has proven to reduce itsmorbidity and mortality. However, malaria is commonly found in remote tropical areas lackinglaboratory support. The introduction of rapid diagnostic tests have offered the potential to extendaccurate malaria diagnosis to areas where traditional microscopy services are not available. Speciesspecifictesting is available for the four human species: P. falciparum, P. vivax, P. malariae, and P.ovale. The most common antigens for rapid tests are P. falciparum histidine-rich Protein-2 (pfHRP2),P. vivax, and Plasmodium spp. lactose dehydrogenase (pLDH). Tests based on the pfHRP2 antigenare specific to P. falciparum, the most dangerous species of malaria, and are more readily availableand less expensive. Tests based on pLDH come in two varieties: pan-malarial tests which detect allmalaria species, or species specific tests that detect malaria species other than P. falciparum.Overall, prompt and accurate parasitological confirmation is an integral part of effective malariamanagement and disease surveillance. Other key interventions to control malaria include treatmentwith artemisinin-based combination therapies, use of insecticidal nets by people at risk, and indoorresidual spraying with insecticide to control the vector mosquitoes.ReferencesWorld Heath Organization (2012). Retrieved from: http://www.who.int/malaria/diagnosis_treatment/en/PATH (2012): Retrieved from: http://www.rapid-diagnostics.org/rti-malaria-diag.htmDunn Labortechnik GmbH · Thelenberg 6 · 53567 AsbachTel. +49 (0)26 83 / 4 30 94 · Fax +49 (0)26 83 / 4 27 76 · e-mail: info@dunnlab.de · Internet: www.dunnlab.de

Additional Plasmodium AntibodiesAntibodiesCat. No. Description CloneC03400M Plasmodium falciparum BDI400C03400P Plasmodium falciparum (HRP labeled) BDI400C03504M Plasmodium falciparum BDI504C01584M Plasmodium falciparum HRP-2 B1242MC01585M Plasmodium falciparum HRP-2 B1245MC01586M Plasmodium falciparum HRP-2 B1243MC86942M Plasmodium falciparum MSP-1 B936PC86943M Plasmodium falciparum MSP-1 B937PC86944M Plasmodium falciparum MSP-1 B938PC86862M Plasmodium falciparum S antigen B932PC86863M Plasmodium falciparum S antigen B933PC86864M Plasmodium falciparum S antigen B934PC86327M Plasmodium vivax CSP B482VC86328M Plasmodium vivax CSP B483VC86634M Plasmodium vivax MSP-1 B484VC86636M Plasmodium vivax MSP-1 B486VC86637M Plasmodium vivax MSP-1 B487VC86638M Plasmodium vivax MSP-1 B488VC86639M Plasmodium vivax MSP-1 B489VDunn Labortechnik GmbH · Thelenberg 6 · 53567 AsbachTel. +49 (0)26 83 / 4 30 94 · Fax +49 (0)26 83 / 4 27 76 · e-mail: info@dunnlab.de · Internet: www.dunnlab.de12/12