Scoring Matrices

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BLOSUM <strong>Matrices</strong>• Developed by Steven Henikoff and Jorja Henikoff in1992• BLOSUM = Block Substitution Matrix– Block = ungapped, highly conserved region in aprotein family

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Drawbacks of PAM Model• Assumes that all types of mutations aredistributed uniformly across proteins.• Uses data from closely related proteins toinfer relationships between very differentproteins

BLOSUM <strong>Matrices</strong>• Developed by Steven Henikoff and Jorja Henikoff in1992• BLOSUM = Block Substitution Matrix– Block = ungapped, highly conserved region in aprotein family

Page 1 and 2: Scoring MatricesThe Arrays Used to
Page 3 and 4: What are Scoring Matrices?• 20x20
Page 5 and 6: Uses of Scoring Matrices• Used in
Page 7 and 8: Genetic Code Matrix• Looks at the
Page 9: Making PAM Matrices• To Create a
Page 13 and 14: BLOSUM Matrices - Clustering• Wha
Page 15 and 16: Summary• The two major sets of sc

Scoring Matrices

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