Coasting and OHSS Coast ga dO SS

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Coasting - Advantages• Cycle not cancelled• No other medical or surgical interventione t • Fresh embryos are put back• Reduces risk of OHSS while maintainingpregnancy rates
CoastingFSH levels decline• Granulosa cell apoptosis(Tortoriello et al. 1998)• Intermediate and small follicles atretic(Dhont et al. 1998)• Decline in E2 & vasoactive mediators (VEGF)(Garcia-Velasco et al. 2004)
Page 1 and 2: Coasting and OHSSMrs Uma GordonBris
Page 4 and 5: Prevention of OHSS• Lower dose of
Page 6 and 7: Prevention of OHSS• Coasting - mo
Page 10: CoastingNo clear cut criteria-When
Page 13 and 14: Coasting - start time?At BCRM, E2 d
Page 15 and 16: Coasting duration - Pregnancy rates
Page 17 and 18: Coasting challenges --what drop in
Page 19 and 20: Bristol Centre ForReproductive Medi
Page 21 and 22: Methodology• GnRH-a long protocol
Page 23 and 24: MethodologyCoasting stopped (ie., h
Page 25 and 26: Serum E2 Assay• Competitive immun
Page 27 and 28: Coastingduration(Days)Cycles(n)No.
Page 29 and 30: Coastingduration(Days)Cycles (n)Ong
Page 31 and 32: Change inE2 levels l (HCG -1to day
Page 33 and 34: Change in E2 levelsCycles(%) (n)Ong
Page 35 and 36: Results 3• 6.1% OHSS in coasted c
Page 37 and 38: Conclusions - 2• Coasting results
Page 39 and 40: OHSS - morbidity and mortality• C
Page 41 and 42: Coasting AuditBCRM - Change of prac
Page 43 and 44: Cochrane review• Coasting vs EUFA
Page 45 and 46: Coasting versus EUFA: OHSS
Page 47 and 48: Coasting versus GnRHa: No. of oocyt
Page 49 and 50: Cochrane review• A significant be
Page 52: No room for over response or OHSSin

Coasting and OHSS Coast ga dO SS

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