Kathy Giacomini - Academic Room

Kathleen M. Giacomini(142) Y. Chen, S. Zhang, M. Sorani, and K.M. Giacomini. Transport of Paraquat by Human OrganicCation Transporters and Multidrug and Toxic Compound Extrusion Family. J Pharmacol ExpTher. Aug; 322(2): 695-700 (2007).(143) T.J. Urban, L.L. Lagpacan, C. Brown, R.A. Castro, T.R. Taylor, C.C. Huang, D. Stryke, S.J.Johns, M. Kawamoto, E.J. Carlson, T.E. Ferrin, E.G. Burchard, and K. M. Giacomini. FunctionalEffects of Protein Sequence Polymorphisms in the Organic Cation/Ergothioneine TransporterOCTN1 (SLC22A4). Pharmcogenet Genomics. Sep; 17(9):773-82 (2007).(144) R.A. Wilke, D.W. Lin, D.M. Roden, P.B. Watkins, D. Flockhart, I. Zineh, K.M. Giacomini, R.M.Krauss. Identifying Genetic Risk Factors for Serious Adverse Drug Reactions; Current Progressand Challenges. Nat Rev Drug Discov. Nov; 6(11): 904-16 (2007).(145) C.D. Cropp, T. Komori, J.E. Shima, T.J. Urban, S.W. Yee, S. More, and K.M. Giacomini. OrganicAnion Transporter 2 (SLC22A7) is a Facilitative Transporter of c GMP. Mol Pharmcol. Apr;73(4):1151-8 (2008).(146) N. Huang, V. Agrawal, K.M. Giacomini, and W.L. Miller. Genetics of P450 Oxidoreductase:Sequence Variation in 842 Individuals of Four Ethnicities and Activities of 15 Missense Mutations.Proc Natl Acad Sci Feb. 5; 105(5):1733-8 (2008).(147) N Abla, L.W. Chinn, T. Nakamura, C.C. Huang, S.J. Johns, M. Kawamoto, D. Stryke, T.R. Taylor,T.E. Ferrin, K.M. Giacomini, and D.L. Kroetz. The Human Multidrug Resistance Protein 4(MRP4, ABCC4): Functional Analysis of Highly Polymorphic Gene. J Pharmacol Exp Ther. Jun;325(3): 859-868 (2008).(148) M.D. Sorani, D. Morabito, G. Rosenthal, K.M. Giacomini, and G.T. Manley. Characterizing theDose-Response Relationship between Mannitol and Intracranial Pressure in Traumatic BrainInjury Patients Using a High-Frequency Physiological Data Collection System. J. Neurotrauma.Apr; 25(4): 91-8 (2008).(149) M.D. Sorani, G.T. Manley, and K.M. Giacomini. Genetic Variation in Human Aquaporins andEffects on Phenotypes of Water Homeostasis. Hum Mutat May; 29(9): 1108-1117 (2008).(150) M.D. Sorani, Z. Zador, E. Hurowitz, D. Yan, K.M. Giacomini, G.T. Manley. Novel Variants inHuman Aquaporin-4 Reduce Cellular Water Permeability. Hum Mol Genet. Aug; 17(15): 2379­89 (2008).(151) K.S. Lovejoy, R.C. Todd, S. Zhang, M.S. McCormick, J.A.D’Aquino, J.T. Reardon, A. Sancar,K.M. Giacomini, and S.J. Lippard. cis-Diammine (pyridine) Chloroplatinum (II), a MonofunctionalPaltinum (II) Antitumor Agent: Uptake, Structure, Function, and Prospects. Proc Natl Acad SciJul 1; 105(26):8902-7 (2008).(152) S.T. Weiss, H.L. McLeod, D.A. Flockhart, M.E. Dolan, N.L. Benowitz, J.A. Johnson, M.J. Ratain,and K.M. Giacomini. Creating and Evaluating Genetic Tests Predictive of Drug Response. NatRev Drug Discov Jul; 7(7):568-74 (2008).(153) Urban,T.J., C. Brown, R.A. Castro, N. Shah, R. Mercer, Y. Huang, C.M. Brett, E.G. Burchard andK.M. Giacomini. Effects of genetic variation in the novel organic cation transporter, OCTN1, onthe renal clearance of gabapentin. Clin.Pharmacol.Ther. 83(3): 416-421 (2008).(154) M. Li, F.A. Hays, Z. Roe-Zurz, L. Vuong, L. Kelly, C.M. Ho, R.M. Robbins, U. Pieper, J.D.O’Connell 3rd, L.J. Miercke, K.M. Giacomini, A. Sali, R.M. Stroud. Selecting Optimum EukaryoticIntegral Membrane Proteins for Structure Determination by Rapid Expression and SolubilizationScreening. J Mol Biol Jan 23; 385(3):820-30 (2009).26