2008 Final Program - American Federation for Medical Research

ChicagoFinal ProgramMid-America ClubChicago, ILApril 24-25, 2008Central Society forClinical ResearchMidwestern SectionAmerican Federationfor Medical ResearchJointly sponsoredby CSCR, MWAFMRand NorthwesternUniversity’sFeinberg Schoolof Medicine

Contact InformationCentral Society for Clinical Research555 East Wells StreetSuite 1100Milwaukee, WI 53202Phone: 414.273.2209Fax: 414.276.3349E-mail: cscr@execinc.comWeb: www.cscr.comMidwestern Section AmericanFederation for Medical Research900 Cummings CenterSuite 221-UBeverly, MA 01915Phone: 978.927.8330Fax: 978.524.0461Web: www.afmr.org

2008 Combined Annual Meeting • Final Program • Mid-America Club, Chicago, IL • April 24-25, 2008Learning ObjectivesThe 2008 Combined Annual Meeting of the Central Society for Clinical Research(CSCR) and the Midwestern Section American Federation for Medical Research(MWAFMR) presents the CSCR Hickam Lecture, MWAFMR Keynote Speaker, twoplenary sessions and an oral abstract session on topics of timely interest for researchersand physicians interested in the broad field of clinical research. Participants at the2008 Combined Annual Meeting will acquire knowledge in clinical researchtechniques and new findings in various aspects of internal medicine and other fields.At the completion of the meeting, participants should be able to:• Recognize the value of new research techniques;• Describe new research findings in cardiology, gastroenterology, pulmonaryand critical care, hematology and oncology, nephrology, infectious disease,allergy, immunology and rheumatology;• Explain the diagnosis and management of diseases and disorders acrossvarious subspecialties of medicine.Accreditation StatementThis activity has been planned and implemented in accordance with the EssentialAreas and Policies of the Accreditation Council for Continuing Medical Educationthrough the joint sponsorship of Northwestern University’s Feinberg School ofMedicine, the Central Society for Clinical Research and the Midwestern sectionAmerican Federation for Medical Research. Northwestern University’s FeinbergSchool of Medicine is accredited by the ACCME to provide continuing medicaleducation for physicians.Northwestern University’s Feinberg School of Medicine designates this educationalactivity for a maximum of 6.25 AMA PRA Category 1 Credit(s) TM . Physicians shouldonly claim credit commensurate with the extent of their participation in the activity.Learning Objectives / Accreditation

2008 Combined Annual Meeting • Final Program • Mid-America Club, Chicago, IL • April 24-25, 2008CME Certificates / Educational SupportCME CertificatesIn order to obtain your AMA PRA Category1 Credits TM certificate for this activity, pleasecomplete the Credit Verification Form includedin your syllabus. Forms should be completed infull and returned to the registration desk at theend of the meeting. Certificates will be mailed4-6 weeks following the activity to the addressprovided on your registration form.Educational SupportThis educational activity is supported byunrestricted educational grants from:Abbott LaboratoriesSanofi-AventisTakeda Pharmaceuticals North America, Inc.Faculty/Speaker Disclosure Statementand Disclosure for Discussions ofOff Label/Investigational Use ofPharmaceutical ProductsIn accordance with ACCME Standardsfor Commercial Support of ContinuingMedical Education and the Feinberg Schoolof Medicine’s disclosure policy for CMEactivities, faculty members have been asked todisclose any relationship they may have withcommercial supporters of this CME activityor with companies providing products ormedical equipment that may have relevanceto the content of their presentations. Suchdisclosure is intended to provide participantswith sufficient information to evaluate whetherany given presentation has been influenced bythe faculty’s relationship(s) or financial interestwith said companies.This activity may include information regardingthe off-label and/or investigational use(s) ofvarious pharmacological agents. The facultyhave disclosed below if they will be discussinga product which is still investigational or notlabeled for the use under discussion.This activity is being jointly sponsoredby the Feinberg School of Medicine, theCentral Society for Clinical Research and theMidwestern Section American Federation forMedical Research. The medical school hasno significant relationship with the commercialcompanies whose products or services arebeing discussed in this educational activity.Course Director’s and Planning CommitteeMembers Disclosure Information:Alan Buchman Consulting fee –NPS PharmaceuticalsSpeakers’ bureau –Abbott LaboratoriesConsulting fee –Bioniche PharmaBrian Hoit Speaking honorarium –MerckSpeaking honorarium –PhilipsDavid Kamp Speaking honorarium –Boehringer IngelheimSpeaking honorarium –GlaxoSmithKlineSpeaking honorarium –Primary Care NetworkJames Martins States he has nothing toFrancis Millerdisclose.States he has nothing todisclose.James Oates Speaking honorarium –AbbottNallini Rajamannan States she has nothing todisclose.Speakers, Moderators and Panelists’Disclosure Information:Joanne Billings Clinical Research SalaryTransave, Inc.Clinical Research SalaryGilead Sciences, Inc.Clinical Research SalaryKaloBios Pharmaceuticals, Inc.Peter Bitterman States he has nothing to disclose.Richard Burt Discussing hematopoietic stemcell transplants for autoimmunedisease.Mark Cannon States he has nothing to disclose.Sarah Cooley States she has nothing to disclose.Michael Fischer Consulting fee, SpeakerHonorarium, Research SupportGlaxoSmithKlineJon George States he has nothing to disclose.Roxanna Irani States she has nothing to disclose.Min JooStates she has nothing to disclose.Thomas Layden States he has nothing to disclose.Robert Sherwin States he has nothing to disclose.William Tierney States he has nothing to disclose.Betty Tran States she has nothing to disclose.Julio VijilSpeakers’ BureauHonorarium - AmgenCornelia Weyand States she has nothing to disclose.

2008 Combined Annual Meeting • Final Program • Mid-America Club, Chicago, IL • April 24-25, 2008Combined Annual Meeting ScheduleThursday, April 24, 20086:00 pm – 8:00 pm Ballroom BWelcome Reception and PosterSessionA complete listing of posters is located at theback of this program.Friday, April 25, 20088:00 am – 8:15 amOpening remarks by James Martins, CSCRPresident, and Francis Miller, MWAFMRPresidentPresentation of Awards to Outstanding YoungInvestigator and Cardiovascular AwardWinnersDepartment Chair Session #18:15 am – 9:00am Ballroom APeter B. Bitterman, PresidingUniversity of Minnesota Medical SchoolVice Chair for Research and Professor,Department of Medicine8:15Natural Killer Cell ReceptorsInfluence Survival afterHematopoietic Cell Transplantation:Implications for Donor SelectionSarah Cooley, Assistant Professor, Departmentof Medicine, University of Minnesota MedicalSchool8:30The KSHV Chemokine ReceptorMark Cannon, Assistant Professor, Departmentof Medicine, University of Minnesota MedicalSchool8:45Women’s Health in Cystic FibrosisJoanne Billings, Assistant Professor, Departmentof Medicine, University of Minnesota MedicalSchool9:00 am – 10:00 am Ballroom ACSCR Hickam LectureJames B. Martins, PresidingFrom the Forest Canopy to the Edgeof the Water: What Can MedicalInformatics Do for Clinical Medicine?William TierneyChancellor’s Professor, Department of Medicine,Indiana University School of MedicineIntermission10:00 am – 10:30 amMWAFMR Keynote Speaker10:30 am – 11:30 am Ballroom AFrancis Miller, PresidingHematopoietic Stem CellTransplantation for AutoimmuneDiseaseRichard BurtChief, Division of Immunotherapy forAutoimmune Diseases and Professor ofMedicine, Northwestern University FeinbergSchool of Medicine11:30 am – 1:30 pm Ballroom BLunch and Poster PresentationsA complete listing of posters is located at theback of this program.

2008 Combined Annual Meeting • Final Program • Mid-America Club, Chicago, IL • April 24-25, 2008Department Chair Session #21:30 pm – 2:15 pm Ballroom AThomas J. Layden, PresidingUniversity of Illinois Medical Center at ChicagoEdmund F. Foley Professor and Chair,Department of Medicine1:30The Role of Chronic Kidney Disease inan Elderly High-Risk PopulationMichael Fischer, Assistant Professor, Departmentof Medicine, University of Illinois at Chicago1:45Geographic Variation of SpirometryUse for a New Diagnosis of COPDMin Joo, Assistant Professor, Department ofMedicine, University of Illinois at Chicago2:00Health - Related Quality of Life inHispanics with Chronic Kidney DiseaseJulio Vijil, Assistant Professor, Department ofMedicine, University of Illinois at ChicagoAFMR Scholar’s Program6:00 pm – 10:00 pmOral Abstract Session2:15 pm – 3:00 pm Ballroom ABrian Hoit and Nalini Rajamannan, Presiding2:15 SERUM F2-ISOPROSTANES ANDOXIDIZED LDL ARE LONGITUDINALLYASSOCIATED WITH LOWER LUNGFUNCTION: THE CARDIA STUDY.Betty Tran, Northwestern UniversityFeinberg School of Medicine2:30 INTRODUCTION OF IGG FROMPREECLAMPTIC PATIENTS INTOPREGNANT MICE LEADS TO MULTIPLEFEATURES OF PREECLAMPSIA VIA AT1RECEPTOR ACTIVATION.Roxanna Irani, University of Texas atHouston2:45 EXPANDED AND GENETICALLYMODIFIED HUMAN CORD BLOOD-DERIVED CD133+ STEM CELLSIMPROVES CARDIAC FUNCTION IN ARAT MODEL OF ACUTE MYOCARDIALINFARCTION.Jon George, University Hospitals Case MedicalCenterAFMR Speaker3:00 pm – 3:55 pm Ballroom AFrancis Miller and James Oates, PresidingDisease Pathways in Large Vessel VasculitisCornelia WeyandDavid C. Lowance, MD Professor of MedicineDepartment of MedicineEmory University School of MedicineOn behalf of the Organizing Committee we would like to thank Centocor for sponsoringthe Scholar’s Program. The purpose of this program is to promote the careers of juniorinvestigators by providing an opportunity for them to present their research in a criticalbut intimate and friendly environment and network with both established and earlyinvestigators in their area of interest. Industry representatives have kindly agreed to fundthis program. The Scholar’s Program is not a CME activity.Combined Annual Meeting Schedule

2008 Combined Annual Meeting • Final Program • Mid-America Club, Chicago, IL • April 24-25, 2008Moderated Poster PresentationsModerated Poster PresentationsThursday, April 24, 20086:00 pm – 8:00 pmWelcome Reception and PosterPresentationsModerator:Jeffrey Glassroth, MD, Vice Dean, Academic andClinical Affairs, Northwestern University42 TARGETING THE AIRWAY SMOOTHMUSCLE WITH STATINS AS APOTENTIAL TREATMENT FOR ASTHMAPresenter: Blanca Camoretti-Mercado, Universityof Chicago32 THE IMPACT OF THE MEDICARE PARTD PRESCRIPTION DRUG BENEFIT ONPRESCRIPTION UTILIZATION AND OUT-OF-POCKET EXPENDITURESPresenter: Atonu Rabbani, University of Chicago122 CYCLIC TRANSITION STATES IN THECATALYSIS OF PROTON TRANSFERIN GLUTAMATE RACEMASE:IMPLICATIONS FOR ANTIBACTERIALDRUG DESIGNPresenter: Dylan Dodd, University of Illinois,Urbana-Champaign124 NEW APPLICATION OF AMIFOSTINE INTREATMENT OF ENDOTOXIN-INDUCEDACUTE LUNG INJURYPresenter: Panfeng Fu, University of ChicagoModerator:Robert Todd, III, Interim Chair of Medicine, Universityof Michigan12 EFFECT OF CYP2C9 AND VKORC1POLYMORPHISMS ON WARFARINDOSE, ANTICOAGULATIONATTAINMENT AND MAINTENANCEAMONG EUROPEAN AMERICAN ANDAFRICAN AMERICANSPresenter: Nita Limdi, University of Alabama atBirmingham60 BACE1 MODULATES MYELINATIONIN THE CENTRAL AND PERIPHERALNERVOUS SYSTEMPresenter: Caitlin Hicks, Cleveland Clinic LernerResearch Institute96 DEFECTIVE T-CELL ERK PATHWAYSIGNALING IN MICE INDUCESINTERFERON-REGULATED GENEEXPRESSION AND OVEREXPRESSIONOF METHYLATION SENSITIVE GENESSIMILAR TO LUPUS PATIENTSPresenter: Amr Sawalha, University of OklahomaHealth Sciences Center132 DONOR CELL INFUSION WITHOUTIMMUNOSUPPRESSION AS A NOVELTHERAPY FOR INDUCTION OF DONOR-SPECIFIC TOLERANCE IN ISLET CELLTRANSPLANTATIONPresenter: Xunrong Luo, Northwestern UniversityModerator:Samuel Dudley, Professor of Medicine, University ofIllinois at Chicago16 LONG-TERM COMPLIANCE WITHGUIDELINE-BASED MEDICAL THERAPIESIS THE STRONGEST PREDICTOR OFEVENT-FREE SURVIVAL FOLLOWINGNON ST-SEGMENT ELEVATION ACUTECORONARY SYNDROMES AND ACUTEMYOCARDIAL INFARCTIONPresenter: Sandeep Nathan, University ofChicago34 THE ROLE OF LYSOPHOSPHATIDIC ACIDSIGNALING IN PROTECTION OF LPS-INDUCED AIRWAY EPITHELIAL BARRIERDYSFUNCTIONPresenter: Yutong Zhao, University of Chicago120 MODULATION OF THE CALCINEURIN/NFAT PATHWAY BY MYOGLOBININHIBITS PATHOLOGIC CARDIACHYPERTROPHYPresenter: Pradeep Mammen, University of TexasSouthwestern Medical Center136 LOW SINGLE DOSE OF INTRAVENOUSSOTALOL CAUSES SIGNIFICANT QTINTERVAL PROLONGATIONPresenter: Janos Molnar, Rosalind FranklinUniversity of Medicine and Science

2008 Combined Annual Meeting • Final Program • Mid-America Club, Chicago, IL • April 24-25, 2008Friday, April 25, 200811:30 pm – 1:30 pmLuncheon Poster PresentationsModerator:Mark E. Anderson, Professor of Medicine and Physiology,University of Iowa1 LOW SERUM 25(OH) VITAMIN D LEVELS(

2008 Combined Annual Meeting • Final Program • Mid-America Club, Chicago, IL • April 24-25, 20082008 Combined Annual Meeting Award WinnersAwardsOutstanding YoungInvestigator AwardPanfeng FuCardiovascular AwardYutong ZhaoK Award GrantsG. Caleb AlexanderHossein ArdehaliDavid AronoffRishi AroraSheldon ChenFarr CurlinMaria DowellRobert EdwardsDavid FleckRobert HooverJeffrey JacobsonAntony KimNida LimdiXunrong LuoPradeep MammenReena MehraCheikh MenaaLee MorrowMani PavuluriElisa RhewRebecca ShillingPhilip SimonianJasvinder SinghRobert WinnUsman ZulfiqarMWAFMR Scholar’s AwardsJoan BeckmanWeiguo ChenCharles KimGabriel LangReena MehraCheikh MenaaNuala MeyerRobert WinnJing ZhaoTrainee Travel AwardsWaqas AhmedJoan BeckmanOttar BergmannQun ChenWeiguo ChenNicole CollettRichard DawsonNeetu DhawanDylan DoddLauren FinePanfeng FuJon GeorgeRakesh GopinathannairDmitry GrigoryevCaitlin HicksMarion Hofmann BowmanJames HwangRoxanna IraniShami JagtapLynn KesslerAntony KimCharles KimEnko KiprilovAleksander KrbanjevicNicolas KummerGabriel LangBonnie LauHyoung-Gon LeeRichard LeeReena MehraCheikh MenaaNader MinaLiliana Moreno-VinascoJitender MunjalHope NicelySrikanth PendyalaBishwal RawalSaad SammaniBriam SchmutzlerSeth SheldonAbhijit ShindeKimberly StaffeyDavid TerranoTing WangJoanna WegrzynRobert WinnJunjie XingJing ZhaoYutong ZhaoUsman Zulfiqar

2008 Combined Annual Meeting • Final Program • Mid-America Club, Chicago, IL • April 24-25, 2008Thursday, April 24, 20086:00 pm – 8:00 pm Ballroom BWelcome Reception and Poster SessionJointly presented byCentral Society for Clinical Research/Midwestern Section American Federationfor Medical ResearchObservational Science2 CASE OF SLE WITH UNUSUALPRESENTATION.C Attoti, A Cochon, D Godkar, B Gala and IShaiful, Brooklyn, NY. Coney Island HospitalAbstract 24 SLOPE OF THE FLOW-TIME WAVEFORMPREDICTS RESPIRATORY SYSTEMRESISTANCE AND COMPLIANCE INMECHANICALLY VENTILATED PATIENTS.ND Collett and GA Schmidt, Iowa City, IA.University of Iowa (Trainee Travel Award Winner)Abstract 46 CATASTROPHIZING ANDPHYSIOLOGICAL RESPONSES TO PAIN.R Edwards, Baltimore, MD. Johns Hopkins(K Award Grant Winner) Abstract 68 aUTOMATED ANALYSIS OF BEHAVIOR:A COMPUTER-CONTROLLED SYSTEMFOR DRUG SCREENING AND THEINVESTIGATION OF LEARNING.C Hicks, D Sorocco and M Levin, Boston, MA.The Forsyth Institute Abstract 810 HYPERINFLATION IS ASSOCIATED WITHLOWER SLEEP EFFICIENCY IN COPDWITH CO-EXISTENT OBSTRUCTIVE SLEEPAPNEA.J Kwon, J Sutter, CL Kuntz, LF Wolfe, BS Lu andR Kalhan, Chicago, IL and Philadelphia, PA.Northwestern University School of MedicineAbstract 1012 EFFECT OF CYP2C9 AND VKORC1POLYMORPHISMS ON WARFARIN DOSE,ANTICOAGULATION ATTAINMENT ANDMAINTENANCE AMONG EUROPEANAMERICAN AND AFRICAN AMERICANS.NA Limdi, M Beasley, JA Goldstein, DK Arnett,G McGwin and RT Acton, Birmingham, AL andResearch Triangle Park, NC. University ofAlabama at Birmingham Abstract 1214 EFFECT OF VITAMIN D ONHYPERTENSION: A META-ANALYSIS.A Mutgi, S Avasthi and S Khuder, Toledo, OH.University of Toledo Health Science CampusAbstract 1416 LONG-TERM COMPLIANCE WITHGUIDELINE-BASED MEDICAL THERAPIES ISTHE STRONGEST PREDICTOR OF EVENT-FREE SURVIVAL FOLLOWING NON ST-SEGMENT ELEVATION ACUTE CORONARYSYNDROMES AND ACUTE MYOCARDIALINFARCTION.S Nathan, AP Amin, E Mukhopadhyay, S Napanand RF Kelly, Chicago, IL. University of ChicagoMedical Center Abstract 1618 STENTED LENGTH TO DIAMETER RATIOASSESSED VIA QUANTITATIVE CORONARYANGIOGRAPHY IS AN EFFECTIVE BEDSIDETOOL FOR PREDICTION OF BARE METALBINARY IN-STENT RESTENOSIS AS WELLAS INCREASED RESTENOTIC COMPLEXITY.S Nathan, MK Reriani, E Mahapatra, V Mwansa,AP Amin, SN Patel, A Kumar and RF Kelly, Chicago,IL. University of Chicago Medical CenterAbstract 1820 FATAL NECROTIZING FASCIITIS WITHMETHICILLIN-RESISTANT STAPHYLOCOCCUSAUREUS (MRSA) COMPLICATING THERAPYOF RHEUMATOID ARTHRITIS WITHINFLIXIMAB.WD Ratnoff and CL Stetson, Lubbock, TX. Texas TechUniversity Health Sciences CenterAbstract 2022 DIFFERENCES IN SUBCLINICALCARDIOVASCULAR DISEASE IN AFRICAN-AMERICAN AND CAUCASIAN WOMENWITH SYSTEMIC LUPUS ERYTHEMATOSUS:A COMBINED ANAYSIS WITH SOLVABLE(CHICAGO) AND HEARTS (PITTSBURGH).EY Rhew, SM Manzi, DD McPherson, AR Dyer, KTGeorge, K Sutton-Tyrrell and R Ramsey-Goldman,Chicago, IL, Pittsburgh, PA and Houston, TX.Northwestern University (K Award Grant Winner)Abstract 2224 CHILDHOOD ASTHMA PREVALENCECORRELATES WITH HOSPITALIZATIONS INCHICAGO NEIGHBORHOODS.S Rosenberg, RS Gupta, S Budinger, GM Mutlu, XZhang and KB Weiss, Chicago, IL and Washington,DC. Northwestern University Feinberg School ofMedicine Abstract 2426 DEVELOPMENT OF A NOVEL BEDSIDETOOL FOR EVALUATING RIGHT-SIDEDINTRACARDIAC PRESSURES USING NON-INVASIVE ULTRASOUND: EARLY RESULTSOF THE NICHE STUDY.AA Shinde, S Fedson, S Rajendran, AS Andersonand AY Kim, Chicago, IL. University of Chicago(Trainee Travel Award Winner) Abstract 26Poster Listing

2008 Combined Annual Meeting • Final Program • Mid-America Club, Chicago, IL • April 24-25, 2008Poster Listing28 THE ANTISYNTHETASE SYNDROME:PRESENTATION AS A MIMIC OFRHEUMATOID ARTHRITIS.E Swenson, G Mumm, C Bartels, C Bell and KMcKown, Madison, WI. University of WisconsinHospitals and Clinics Abstract 2830 TRANSESOPHAGEAL ECHOCARDIOGRAMOF THE DESCENDING THORACICAORTA: ESTABLISHING AN ACCURATEANATOMIC MARKER USING THE CELIACARTERY.SC Vasaiwala, J Connolly and L Frazin, Chicago,IL. University of Illinois at Chicago Abstract 3032 THE IMPACT OF THE MEDICARE PARTD PRESCRIPTION DRUG BENEFIT ONPRESCRIPTION UTILIZATION AND OUT-OF-POCKET EXPENDITURES.W Yin, A Basu, J Zhang, A Rabbani, DMeltzern and G Alexander, Chicago, IL. Universityof Chicago(K Award Grant Winner) Abstract 3234 THE ROLE OF LYSOPHOSPHATIDIC ACIDSIGNALING IN PROTECTION OF LPS-INDUCED AIRWAY EPITHELIAL BARRIERDYSFUNCTION.Y Zhao, D He, PV Usatuyk, EW Spannhake andV Natarajan, Chicago, IL and Baltimore, MD. TheUniversity of Chicago (Cardiovascular Award and TraineeTravel Award Winner) Abstract 34Understanding Mechanisms of Disease36 MISOPROSTOL INHIBITS FEMALEREPRODUCTIVE TRACT INNATE IMMUNEDEFENSES AGAINST CLOSTRIDIUMSORDELLII.D Aronoff, Y Hao, J Chung, C Peres, H Serezani,N Coleman, C Lewis, T Brock and M Peters-Golden, Ann Arbor, MI. University of Michigan(K Award Grant Winner) Abstract 3638 AKT ACTIVATES ENOS ANDRESTORES BARRIER INTEGRITY INHUMAN CARDIAC MICROVASCULARENDOTHELIAL CELLS DURING OXIDANTSTRESS.E Berdyshev, D Anar, I Gorshkova, Z Shao, C Li,P Long, A Joshi, V Natarajan and T Vanden Hoek,Chicago, IL. University of Chicago Abstract 3840 ENKEPHALIN RECEPTOR ACTIVATIONATTENUATES ABDOMINALAORTIC ANEURYSM FORMATIONIN ANGIOTENSIN II INFUSEDAPOLIPOPROTEIN E-DEFICIENT MICE.AL Blomkalns, SM Ormond, LL Stoll, GM Denning,EW Dickson and NL Weintraub, Cincinnati, OHand Iowa City, IA. University of Cincinnati Collegeof Medicine Abstract 4042 TARGETING THE AIRWAY SMOOTHMUSCLE WITH STATINS AS A POTENTIALTREATMENT FOR ASTHMA.B Camoretti-Mercado, X Li, J Churchill, K Poon,J McConville, V Sandwick, C Cummings, CGLee, JA Elias and J Solway, Chicago, IL and NewHaven, CT. The University of Chicago Abstract 4244 AIRWAY HYPERRESPONSIVENESS INGATA5-DEFICIENT MICE.B Chen, Y Li, J Churchill, M Tran, T Moore,M Dowell, O Lakser, RW Mitchell, PJ Gruber,EE Morrisey and J Solway, Chicago, IL andPhiladelphia, PA. The University of ChicagoAbstract 4446 ISCHEMIC DAMAGE TO THEMITOCHONDRIAL ELECTRONTRANSPORT CHAIN: MECHANISMOF CARDIAC INJURY DURINGREPERFUSION.Q Chen and EJ Lesnefsky, Cleveland, OH. CaseWestern Reserve University Abstract 4650 P53-DEPENDENT TRANSCRIPTION OFNOXA MEDIATES ASBESTOS-INDUCEDALVEOLAR EPITHELIAL CELL APOPTOSIS.N Dhawan, G Liu, S Soberanes, D Ulrich, SEChiarella, N Chandel, GM Mutlu, G Budingerand DW Kamp, Chicago, IL. Jesse Brown VAMCand Northwestern University Feinberg School ofMedicine (Trainee Travel Award Winner) Abstract 5052 A SINGLE NUCLEOTIDE POLYMORPHISMIN THE HUMAN CORTACTINGENE ALTERS PROTEIN TYROSINEPHOSPHORYLATION AND FUNCTION.S Dudek, S Camp, A Desai, S Ma and J Garcia,Chicago, IL. University of Chicago Abstract 5254 LONGITUDINAL RELATIONSHIP OFTOTAL IGE AND DUST MITE ANTIGENDER P 1 SPECIFIC IGE TO SYMPTOMS OFALLERGIC ASTHMA.B Fritsch, L Fine, C Onumah, MB Miller, WZhong, S Kelleher, C Liebeler and M Blumenthal,Minneapolis, MN. University of MinnesotaAbstract 5456 IDENTIFICATION OF A NOVEL REGIONFOR AIS ON CHROMOSOME 12P WITHAN AUTOSOMAL RECESSIVE ANDDOMINANT MODEL OF INHERITANCE.PF Giampietro, CL Raggio, S Dobrin, C Zhao, DDorshorst, JL Weber and RD Blank, Marshfield,WI, New York, NY and Madison, WI.Marshfield Clinic Abstract 5610

2008 Combined Annual Meeting • Final Program • Mid-America Club, Chicago, IL • April 24-25, 2008Poster Listing88 ANALYSIS OF DEAFFERENTATION-INDUCED CELL DEATH IN CHICKCOCHLEAR NUCLEUS NEURONS USINGTUNEL LABELING, LASER CAPTUREMICRODISSECTION, AND PCR ARRAYS.HK Nicely and D Durham, Kansas City, KS.University of Kansas Medical Center(Trainee Travel Award Winner) Abstract 8890 RNA-DEPENDENT SELENOCYSTEINEBIOSYNTHESIS IN EUKARYOTES ANDARCHAEA.S Palioura, J Yuan, D Su, Y Araiso, O Nureki,WB Whitman and D Soll, New Haven, CT,Kanagawa, Japan and Athens, GA. YaleUniversity School of Medicine Abstract 9092 FUNCTIONAL BRAIN MODEL INPEDIATRIC BIPOLAR DISORDER: ADEVELOPMENTAL MODEL OF BRAINPATHOPHYSIOLOGY.MN Pavuluri, J Sweeney and X Zhou, Chicago, IL.University of Illinois at Chicago(K Award Grant Winner) Abstract 9294 DIFFERENTIAL RESPONSES AFTERREVERSIBLE UNILATERAL URETERALOBSTRUCTION IN MURINE STRAINSSUSCEPTIBLE AND RESISTANT TODEVELOPMENT OF CHRONIC KIDNEYDISEASE.T Puri, L Mathew, M Shakaib, O Olayinka, AMinto, Z Wang, L Hensley, M Karmegam, BHack, A Chang and R Quigg, Chicago, IL.University of Chicago Abstract 9496 DEFECTIVE T-CELL ERK PATHWAYSIGNALING IN MICE INDUCESINTERFERON-REGULATED GENEEXPRESSION AND OVEREXPRESSIONOF METHYLATION SENSITIVE GENESSIMILAR TO LUPUS PATIENTS.AH Sawalha, M Jeffries, R Webb, Q Lu, GGorelik, D Ray, K Johnson and B Richardson,Oklahoma City, OK, Ann Arbor, MI andChangsha, China. University of Oklahoma HealthSciences Center Abstract 9698 LYMPHOCYTIC BRONCHIOLITIS IN ANOVEL MODEL OF CHRONIC LUNGREJECTION.RA Shilling, E Berry, AI Sperling and M Alegre,Chicago, IL. University of Chicago(K Award Grant Winner) Abstract 98100 HIGH MW HYALURONAN-MEDIATEDCD44 SIGNALING IN CAVEOLIN-ENRICHED MICRODOMAINS ENHANCESVASCULAR INTEGRITY.PA Singleton, Y Guo, F Arce, J Whitlock, L Moreno-Vinasco, J Moitra, S Sammani, T Mirzapoiazova, RLal and J Garcia, Chicago, IL and Baltimore, MD.University of Chicago Abstract 100102 AN OXIDIZED EXTRACELLULAR REDOXSTATE INCREASES NOX1 EXPRESSION INVASCULAR SMOOTH MUSCLE CELLS.B Stanic and F Miller, Iowa City, IA. Universityof Iowa Abstract 102104 GLUCOSE PHOSPHORYLATION ANDMITOCHONDRIAL BINDING AREREQUIRED FOR THE PROTECTIVE EFFECTSOF HEXOKINASE I AND II.L Sun, S Shukair, TJ Naik, F Moazed and HArdehali, Chicago, IL. Northwestern University(K Award Grant Winner) Abstract 104106 DEVELOPMENT OF A SPECIFIC ASSAY FORDETECTION AND PURIFICATION OF THEMICROTUBULE-INHIBITOR ACTIVATEDBCL-XL KINASE, A KEY ENZYME LINKINGMITOTIC ARREST AND APOPTOSIS.D Terrano and TC Chambers, Little Rock, AR.University of Arkansas for Medical Sciences(Trainee Travel Award Winner) Abstract 106108 A NOVEL ROLE FOR MITOCHONDRIAL-LOCALIZED STAT3 IN CARDIACMITOCHONDRIA.J Wegrzyn, R Potla, Y Chwae, Q Zhang, M Szelag,Q Chen, J Dulak, X Fu, EJ Lesnefsky and AC Larner,Cleveland, OH, Richmond, VA, Krakow, Poland andIndianapolis, IN. Virginia Commonwealth University(Trainee Travel Award Winner) Abstract 108110 EPAC/RAP AND PKA MEDIATE ANP-INDUCED ENDOTHELIAL BARRIERPROTECTION.J Xing, E Alekseeva, K Birukov and A Birukova,Chicago, IL and La Jolla, CA. The University ofChicago (Trainee Travel Award Winner) Abstract 110112 DISSECTING THE MECHANISMS OFPULMONARY FIBROSIS IN MICE WITHGENETIC DISORDERS OF INTRACELLULARTRAFFICKING.LR Young, P Gulleman and FX McCormack,Cincinnati, OH. University of CincinnatiAbstract 11212

2008 Combined Annual Meeting • Final Program • Mid-America Club, Chicago, IL • April 24-25, 2008Investigating Disease Modulation andIntervention114 DIFFERENTIAL ROLE OF EZRIN/RADIXIN/MOESIN PROTEINS IN AGONIST-INDUCED PULMONARY ENDOTHELIALCELL BARRIER ENHANCEMENT.DM Adyshev, SM Dudek and JG Garcia,Chicago, IL. University of ChicagoAbstract 114116 INFLAMMATION AND OXIDATIVE STRESSIN TRANSGENIC SICKLE MICE: INHALEDCARBON MONOXIDE AS A POTENTIALANTI-INFLAMMATORY AGENT.JD Beckman, JV Vineyard, JD Belcher and GMVercellotti, Minneapolis, MN. University ofMinnesota (Trainee Travel Award and MWAFMR CentocorScholar’s Award Winner) Abstract 116118 ATORVASTATIN INHIBITSHYPERCHOLESTEROLEMIA-INDUCEDPROLIFERATION AND EXTRACELLULARMATRIX PRODUCTION IN THE RENALGLOMERULI VIA THE WNT/LRP5RECEPTOR PATHWAY.FC Caira, T Manca and NM Rajamannan,Chicago, IL. Northwestern UniversityAbstract 118120 MODULATION OF THE CALCINEURIN/NFAT PATHWAY BY MYOGLOBININHIBITS PATHOLOGIC CARDIACHYPERTROPHY.R Chirumamilla, S Singh, T Nguyen, RD Gerard,Z Yan, JA Hill and PP Mammen, Dallas, TX andDurham, NC. UT Southwestern Medical Center(K Award Grant Winner) Abstract 120122 CYCLIC TRANSITION STATES IN THECATALYSIS OF PROTON TRANSFER INGLUTAMATE RACEMASE: IMPLICATIONSFOR ANTIBACTERIAL DRUG DESIGN.D Dodd, J Baudry, K Pankow, JG Reese, SRBlanke and MA Spies, Urbana, IL. University ofIllinois, Urbana-Champaign(Trainee Travel Award Winner) Abstract 122124 NEW APPLICATION OF AMIFOSTINE INTREATMENT OF ENDOTOXIN-INDUCEDACUTE LUNG INJURY.P Fu, AA Birukova, S Sammani, DBurdette, JS Murley, JG Garcia, DJGrdina and KG Birukov, Chicago, IL. University ofChicago (Trainee Travel Award Winner)Abstract 124126 EXPANDED AND GENETICALLYMODIFIED HUMAN CORD BLOOD-DERIVED CD133+ STEM CELLSIMPROVES CARDIAC FUNCTION IN ARAT MODEL OF ACUTE MYOCARDIALINFARCTION.JC George, H Das, N Abdulhameed, M Joseph,A Liner, BD Hoit and VJ Pompili, Cleveland, OH.University Hospitals Case Medical Center (TraineeTravel Award Winner)Abstract 126128 ULTRASONIC EVIDENCE OFPPREVENTION OF CORONARYCOLLAGEN PROGRESSION DURINGCALCIUM THERAPY IN TYPE A WOMEN.S Jagtap, R Barndt, J Hwang, N Mina, R Dawsonand A Stavrakis, Downey, CA. Bethel PublicService Clinic (Trainee Travel Award Winner)Abstract 128130 SEPARATION OF THE EFFECTS OF CHIRALISOLATES OF METHADONE ON HERGCURRENT.C Lin, V Ranade, X Ke, J Molnar and JC Somberg,Chicago, IL and Lake Bluff, IL. Rush UniversityAbstract 130132 DONOR CELL INFUSION WITHOUTIMMUNOSUPPRESSION AS A NOVELTHERAPY FOR INDUCTION OF DONOR-SPECIFIC TOLERANCE IN ISLET CELLTRANSPLANTATION.X Luo, K Pothoven, D MaCarthy and S Miller,Chicago, IL. Northwestern University(K Award Grant Winner) Abstract 132134 EXAMINING OXIDATIVE STRESS ANDINFLAMMATION IN SLEEP APNEA ASMEDIATORS OF CARDIOVASCULARDISEASE.R Mehra, BD Hoit, SL Hazen and S Redline,Cleveland, OH. Case School of Medicine(Trainee Travel Award, K Award Grant and MWAFMR CentocorScholar’s Award Winner) Abstract 134136 LOW SINGLE DOSE OF INTRAVENOUSSOTALOL CAUSES SIGNIFICANT QTINTERVAL PROLONGATION.J Molnar, V Ranade, RA Preston and JC Somberg,Lake Bluff, IL, Chicago, IL and Miami, FL.Academic Pharmaceuticals Abstract 136Poster Listing13

2008 Combined Annual Meeting • Final Program • Mid-America Club, Chicago, IL • April 24-25, 2008Poster Listing138 INITIAL PLATELET INHIBITIONEXPERIENCE IN A PRECLINICAL MODELTO STUDY THE IMPACT OF ANTIPLATELETTHERAPY ON INTIMAL HYPERPLASIA OFARTERIALIZED VENOUS CONDUIT.S Nathan, VA Lonchyna, EJ Okum, V Mwansa, RNubani, L Kistler, J Turner, SB Hughey, A Oates, PTheiss and RS Higgins, Chicago, IL. University ofChicago Medical Center Abstract 138140 EFFECT OF S1P1 RECEPTOR AGONISTSON MURINE LUNG AIRWAY FUNCTION.S Sammani, T Mirzapoiazova, L Moreno-Vinascoand J Garcia, Chicago, IL. U of Chicago(Trainee Travel Award Winner) Abstract 140142 PH INDUCED DIFFERENCES IN ACTIONPOTENTIAL DURATION HETEROGENEITYBETWEEN QUINIDINE ANDAMIODARONE.JC Somberg, Q Zhou, J Fox and C Lin, Chicago,IL. Rush University Abstract 142144 ADALIMUMAB AS A NOVEL THERAPYFOR REFRACTORY SARCOIDOSIS:PRELIMINARY RESULTS OF A 52-WEEKTRIAL.NJ Sweiss, I Noth, R Baughman, M Ellman, JCurran, K Hogarth, M Strek, M Alegre, M Clark,P Caligiuri and A Pangan, Chicago, IL, AbbottPark, IL and Cincinnati, OH. University of ChicagoAbstract 144Combined Poster Session and LunchJointly presented byCentral Society for Clinical Research/MidwesternSection American Federation for Medical ResearchFriday, April 25, 200811:30 am – 1:30 pm • Ballroom BObservational Science1 LOW SERUM 25(OH) VITAMIN D LEVELS(

2008 Combined Annual Meeting • Final Program • Mid-America Club, Chicago, IL • April 24-25, 200815 LOWER SOCIOECONOMIC STATUSIS INDEPENDENTLY PREDICTIVE OFMAJOR ADVERSE CARDIAC EVENTSPOST-PERCUTANEOUS CORONARYINTERVENTION IN AN OPEN COHORT OFPUBLIC HEALTH SYSTEM PATIENTS.S Nathan, AP Amin, S Attanasio, R Mahidhar, SNapan, S Kadri, MN Orig and RF Kelly, Chicago,IL. University of Chicago Medical CenterAbstract 1517 LONG-TERM CLINICAL OUTCOMES INAN OPEN COHORT OF PUBLIC HEALTHSYSTEM PATIENTS UNDERGOING DRUG-ELUTING STENT (DES) IMPLANTATION FORON-LABEL VS. OFF-LABEL INDICATIONS.S Nathan, S Attanasio, AP Amin, S Napan,R Mahidhar, MN Orig, S Kadri and RF Kelly,Chicago, IL. University of Chicago Medical CenterAbstract 1719 NON-RANDOM DISTRIBUTION ANDSENSORY FUNCTIONS OF PRIMARY CILIAIN VASCULAR SMOOTH MUSCLE CELLS.Q Qian, Rochester, MN. Mayo ClinicAbstract 1921 SHOULD HIGH CREATINEPHOSPHOKINASE (CPK) LEVELSDISCOURAGE THE USE OFSTATINS FOR THE TREATMENT OFHYPERCHOLESTEROLEMIA?BB Rawal, CJ Glueck, NA Khan, W Ahmed andP Wang, Cincinnati, OH. The Jewish Hospital(Trainee Travel Award Winner) Abstract 2123 ANTIBIOTIC ADMINISTRATION ISASSOCIATED WITH INCREASED LENGTH-OF-STAY IN PATIENTS HOSPITALIZED FORINFLUENZA.E Riggle, R Kalhan and R Wunderink, Chicago, IL.Northwestern University Abstract 2325 CORONARY ARTERY DOMINANCE:CORRELATION WITH FALSE POSITIVEREGIONAL MYOCARDIAL PERFUSIONABNORMALITIES.S Sheldon, P Tadros, J Vacek, C Jones, T Rosamondand MA Wiley, Kansas City, KS. University ofKansas Hospital Abstract 2527 C-REACTIVE PROTEIN AS A MARKER OFDISEASE ACTIVITY AND AS A PREDICTOROF INFLIXIMAB TREATMENT OUTCOME INPATIENTS WITH CHRONIC SARCOIDOSIS.NJ Sweiss, E Barnathan, K Lo, M Alegre and RBaughman, Chicago, IL, Cincinnati, OH andPennsylvania, PA. University of ChicagoAbstract 2729 SERUM F2-ISOPROSTANES ANDOXIDIZED LDL ARE LONGITUDINALLYASSOCIATED WITH LOWER LUNGFUNCTION: THE CARDIA STUDY.B Tran, L Colangelo, B Thyagarajan, AArynchyn, K Liu, P Holvoet, DR Jacobs, LJ Smithand R Kalhan, Chicago, IL, Minneapolis,MN, Birmingham, AL and Leuven, Belgium.Northwestern University Feinberg School ofMedicine Abstract 2931 ETHNIC DIVERSITY IN THE TREATMENTOF ACUTE MYOCARDIAL INFARCTIONWITH FIBRINOLYTICS: FOCUS ON THEHIPANIC/LATINO POPULATION.SC Vasaiwala and M Vidovich,Chicago, IL. University of Illinois at ChicagoAbstract 3133 IDENTIFICATION PROTEIN KINASEA-MEDIATED ENDOTHELIAL CELLMYOSINE LIGHT CHAIN KINASEPHOSPHORYLATION SITES BYNANO-LC/MS/MS.J Zhao, SM Camp, ET Chiang, AB Schilling,SM Dudek and JG Garcia, Chicago, IL.University of Chicago (Trainee Travel Award andMWAFMR Centocor Scholar’s Award Winner) Abstract 3335 HEALTHY LONGEVITY; ROLE OFPRESERVED AUTONOMIC FUNCTION (AF).U Zulfiqar, DH Singer, M Zulfiqar and DJurivich, Chicago, IL and Lahore, Pakistan. UIC,Chicago, IL (Trainee Travel Award and K AwardGrant Winner) Abstract 35Understanding Mechanisms of Disease37 ATRIAL AUTONOMIC REMODELING INA CANINE MODEL OF CONGESTIVEHEART FAILURE.R Arora, R Villuendas and A Kadish, Chicago,IL. Northwestern University-Feinberg School ofMedicine (K Award Grant Winner) Abstract 3739 UPREGULATION OF FERROPORTINAND DIVALENT METAL TRANS-PORTER-1 IN CIRRHOTIC HUMAN LIVERS: ALINK TO HEMOSIDEROSIS?OM Bergmann, M Mathahs, K Broadhurst, JAWeydert, N Wilkinson, JR Howe, WN Schmidtand KE Brown, Iowa City, IA. University of IowaCarver College of Medicine(Trainee Travel Award Winner) Abstract 3941 HORMONAL BIOLOGICAL AMINESDETOXIFY EFFECTS OF ACETALDEHYDEUPON APTT.AS Brecher and SJ Murrey, Bowling Green, OH.Bowling Green State University Abstract 41Poster Listing15

2008 Combined Annual Meeting • Final Program • Mid-America Club, Chicago, IL • April 24-25, 2008Poster Listing43 DIFFERENTIAL SENSITIVITY OF HUMANAND MOUSE MACROPHAGES TOBACILLUS ANTHRACIS LETHAL TOXIN.K Chakrabarty, J Booth, ES Duggan, W Wu, KCoggeshall and JP Metcalf, Oklahoma City, OK.University of Oklahoma Health Sciences CenterAbstract 4345 HYPERTROPHIC CARDIOMYOPATHYDUE TO OVEREXPRESSION OF THEONCOGENE C-MYC RESULTS INMITOCHONDRIAL DYSFUNCTIONAT ELECTRON TRANSPORT CHAINCOMPLEX I.Q Chen, H Lee, SL Richardson, A Liner, BD Hoit,EJ Lesnefsky and M Smith, Cleveland, OH. CaseWestern Reserve University(Trainee Travel Award Winner) Abstract 4547 CORONARY COLLAGEN STENOSISPREDICTION AND MONITORING INASYMPTOMATIC PEOPLE USING PULSEPRESSURE AND ULTRSOUND.R Dawson, R Barndt, N Mina, AY Cho and DAhn, Downey, CA. Bethel Public Service Clinic(Trainee Travel Award Winner) Abstract 4751 MEK1 INHIBITION AUGMENTSFORCE FLUCTUATION-INDUCEDRELENGTHENING OF CONTRACTEDCANINE TRACHEAL SMOOTH MUSCLE.ML Dowell, TL Lavoie, OJ Lakser, RW Mitchell andJ Solway, Chicago, IL. University of Chicago(K Award Grant Winner) Abstract 5153 THE NEUROPHYSIOLOGICALCORRELATES OF SUSTAINED ATTENTIONDEFICITS IN BIPOLAR MANIA.DE Fleck, JC Eliassen, M Durling, M Lamy andSM Strakowski, Cincinnati, OH. University ofCincinnati (K Award Grant Winner) Abstract 5355 AGED RAT HEART: DECREASED SUBUNITOF CYTOCHROME OXIDASE BY HIGHRESOLUTION IMMUNOELECTRONMICROSCOPY.H Fujioka, DG Murdock, EJ Lesnefsky and CLHoppel, Cleveland, OH and Nashville, TN.Case Western Reserve UniversityAbstract 5557 EVIDENCE FOR T(BRACHYURY) AS ACANDIDATE GENE FOR VERTEBRALMALFORMATIONS.PF Giampietro, CL Raggio, N Ghebranious, JStaubli, E McPherson, L Ivacic, K Rasmussen, FSJacobsen, T Faciszewski, RM Pauli, J Burmester,I Glurich, O Boachie-Adjei and RD Blank,Marshfield, WI, New York, NY and Madison,WI. Marshfield Clinic Abstract 5759 S100 A12 IS INCREASED IN PATIENTSWITH PULMONARY HYPERTENSIONAND INDUCES SMOOTH MUSCLE CELLPROLIFERATION IN VITRO.MA Hofmann Bowman, EM McNally, SL Archerand M Gomberg, Chicago, IL. University ofChicago Medical Center (Trainee Travel Award Winner)Abstract 5961 METHODS TO REGULATE ADRENERGICNEUROVASCULAR TONE TO REDUCESYMPTOM LEVELS.J Hwang, R Barndt, S Jagtap, R Dawson, N Mina,D Ahn and ML Wong, Downey, CA. Bethel PublicService Clinic (Trainee Travel Award Winner)Abstract 6163 INTRODUCTION OF IGG FROMPREECLAMPTIC PATIENTS INTO PREGNANTMICE LEADS TO MULTIPLE FEATURESOF PREECLAMPSIA VIA AT1 RECEPTORACTIVATION.RA Irani, CC Zhou, Y Zhang, SM Ramin, RE Kellemsand Y Xia, Houston, TX. University of Texas atHouston (Trainee Travel Award Winner)Abstract 6365 REGRESSION OF CORONARY COLLAGENSTENOSIS IN WOMEN ON CALCIUMTHERAPY.S Jagtap, R Barndt, R Dawson, J Hwang, ML Wongand A Stravakis, Downey, CA. Bethel Public ServiceClinic Abstract 6567 PTPN22 C1858T POLYMORPHISM ISASSOCIATED WITH SKEWING OF SERUMCYTOKINE PROFILES TOWARD HIGH IFN-αACTIVITY AND LOW TNF-α IN SYSTEMICLUPUS ERYTHEMATOSUS PATIENTS.SN Kariuki, MK Crow and TB Niewold, Chicago,IL and New York, NY. University of ChicagoAbstract 6769 SLC26A9 EXPRESSION AND CL-/HCO3-EXCHANGE ACTIVITY IN HUMAN ANDMURINE TRACHEAL EPITHELIAL CELLS.C Kim, DW McGraw, J Xu and M Soleimani,Cincinnati, OH. University of Cincinnati (Trainee TravelAward and MWAFMR Centocor Scholar’s Award Winner)Abstract 6971 PTH SUPPRESSES SODIUM CHLORIDECOTRANSPORTER ACTIVITY BY A MAPK-DEPENDENT PROCESS.B Ko, L Cooke and RS Hoover, Chicago, IL.University of Chicago (K Award Grant Winner)Abstract 7116

2008 Combined Annual Meeting • Final Program • Mid-America Club, Chicago, IL • April 24-25, 200873 UPREGULATION OF ARACHIDONICACID 5-LIPOXYGENASE IN PAPILLARYTHYROID CARCINOMA CORRELATES WITHINCREASED TUMOR INVASION IN VIVOAND IN VITRO.NT Kummer, J Azzi, C Iacob, ZR Komorowski, NSuslina, S Schantz, S Schaefer, RK Tiwari and JGeliebter, Valhalla, NY and New York, NY. NewYork Medical College (Trainee Travel Award Winner)Abstract 7375 RECRUITMENT OF A STEM CELLANTIGEN-1 POSITIVE CELL POPULATIONTO ORTHOTOPIC MALIGNANTMESOTHELIOMA SPHEROIDS.B Lau, NJ Messier and AB Kane, Providence, RI.Brown University (Trainee Travel Award Winner)Abstract 7577 THE TGF-β-STIMULATED PRODUCTION OFMONOCYTE CHEMOATTRACTANT PROTEIN(MCP)-1 BY PODOCYTES INFLUENCESPODOCYTE MOTILITY AND PERMEABILITY:EVIDENCE FOR AN MCP-1 AUTOCRINELOOP.E Lee, C Chung, A Wang, P Pyagay and S Chen,Chicago, IL. Northwestern University(K Award Grant Winner) Abstract 7779 INHIBITION OF MITOCHONDRIALRESPIRATION AND ALTERED MYOCARDIALPERFORMANCE IN ENDOTOXINCHALLENGED RATS.KE Mason, D Stofan, A Liner and B Hoit,Cleveland, OH. University Hospitals and CaseMedical Center Abstract 7981 THE CONSTITUTIVE ACTIVITY OF THENF-KB P65/P50 TRANSCRIPTIONALCOMPLEX IS CRITICAL FOR BONEMETASTASIS IN BREAST CANCER.C Menaa, A Moscovitz, S Kim, CJ Froelich andSM Sprague, Evanston, IL and Jerusalem, Israel.Evanston Northwestern Healthcare (Trainee Travel Award,K Award Grant and MWAFMR Centocor Scholar’s Award Winner)Abstract 8183 PREVENTION AND REGRESSION OFRESTRICTIVE CARDIOMYOPATHY DUE TOCALCIUM THERAPY IN TYPE A WOMEN.N Mina, R Barndt, S Jagtap, J Hwang, A Stavrakisand R Dawson, PO Box 4921, CA. Bethel PublicService Clinic Abstract 8385 MURINE PULMONARY RESPONSESTO AIRBORNE PARTICULATE MATTER:GENOMIC ANALYSIS AND CONTRIBUTIONTO AIRWAY HYPERRESPONSIVENESS.L Moreno-Vinasco, T Wang, Y Huang, J Linares,G Lang, SN Goonewardena, A Geyh, P Breysse,JM Samet, V Natarajan, Y Lussier and JG Garcia,Chicago, IL, Baltimore, MD and Ann Arbor, MI.University of Chicago (Trainee Travel Award Winner)Abstract 8587 RECURRENT SLEEP CURTAILMENT ISACCOMPANIED BY INCREASED INTAKE OFCALORIES FROM SNACKS.AV Nedeltcheva, J Kilkus, J Imperial, K Kasza, DSchoeller and PD Penev, Chicago, IL and Madison,WI. University of Chicago Abstract 8789 CIGARETTE SMOKE INDUCES CELLULARSENESCENCE VIA WERNER’S SYNDROMEPROTEIN DOWNREGULATION.T Nyunoya, MM Monick, CO Brown, E Matsumonoand GW Hunninghake, Iowa City, IA.University of Iowa Abstract 8991 STRA6 IS EXPRESSED IN THEENDOMETRIUM AND IS ABSENT INENDOMETRIOSIS.M Pavone, SE Bulun, SS Reierstad, J Innes and YCheng, Chicago, IL. Northwestern UniversityAbstract 9193 ROLE OF NOX4 IN ENDOTHELIAL CELLSIGNALING, ROS GENERATION ANDMOTILITY.S Pendyala, I Gorshkova, PV Usatyuk, SK Kalari,M Burns, D He, VJ Thannickal and V Natarajan,Chicago, IL. University of Chicago (Trainee Travel Awardand MWAMFR Centocor Scholar’s Award Winner) Abstract 9395 GENE EXPRESSION CHANGES MEDIATEDBY PRE-B-CELL COLONY ENHANCINGFACTOR IN VENTILATOR-INDUCED LUNGINJURY (VILI).RR Reeves, Y Huang, L Moreno-Vinasco, S Sammani,S Hong, S Ma, J Moitra, T Mirzapoiazova, CEvenoski, SQ Ye, YA Lussier and J Garcia, Chicago, IL,Columbia, MO and Seoul, South Korea. University ofChicago Medical Center Abstract 9597 GLIAL CELL LINE-DERIVED NEUROTROPHICFACTOR (GDNF) FAMILY LIGANDS(GFLS) ENHANCE THE RELEASE OF THENEUROPEPTIDE CGRP.BS Schmutzler and CM Hingtgen, Indianapolis, IN.Indiana University School of Medicine(Trainee Travel Award Winner) Abstract 9799 CD4+ T CELLS PROMOTE PULMONARYFIBROSIS IN A MURINE MODEL OFHYPERSENSITIVITY PNEUMONITIS.PL Simonian, CL Roark, WK Born, RL O’Brien andAP Fontenot, Denver, CO. University of Colorado(K Award Grant Winner) Abstract 99Poster Listing17

2008 Combined Annual Meeting • Final Program • Mid-America Club, Chicago, IL • April 24-25, 2008Poster Listing101 HABP2 REGULATES ENDOTHELIAL CELLPERMEABILITY: ROLE OF HYALURONAN,PAR RECEPTORS, TENASCIN-C ANDPERLECAN.PA Singleton, N Mambetsariev, T Mirzapoiazova,B Mambetsariev and J Garcia, Chicago, IL.University of Chicago Abstract 101103 SUBREGIONAL COMPARISONSOF REAL-TIME GLUTAMATENEUROTRANSMISSION IN THE RATHIPPOCAMPUS DURING AGING.ML Stephens, JE Quintero, P Huettl, F Pomerleauand GA Gerhardt, Lexington, KY. University ofKentucky Abstract 103105 PP2A MODULATES ERKDEPHOSPHORYLATION IN MONOCYTESEXPOSED TO ASBESTOS.LA Tephly and A Carter, Iowa City, IA. Universityof Iowa Carver College of MedicineAbstract 105107 REACTIVE OXYGEN SPECIES ANDP38 MAPK ACTIVATION MEDIATEPARTICULATE MATTER CAUSEDENDOTHELIAL CELL BARRIERDISRUPTION.T Wang, L Moreno-Vinasco, S Pendyala, ETChiang, GD Lang, JM Samet, AS Geyh, PNBreysse, V Natarajan and JG Garcia, Chicago, ILand Baltimore, MD. University of Chicago(Trainee Travel Award Winner) Abstract 107109 PROSTACYCLIN AND ITS SYNTHETICANALOGUES ARE SMALL MOLECULEAGONISTS OF FRIZZLED 9 MEDIATINGGROWTH INHIBITION OF NON SMALLCELL LUNG CANCER CELLS.RA Winn, M Tennis, A Sergew, L Williams, JRandall and M Van Scoyk, Denver, CO. DenverVAMC (Trainee Travel Award, K Award Grant and MWAFMRCentocor Scholar’s Award Winner)Abstract 109111 HEPARANASE EXPRESSION ANDREGULATION BY HIGH GLUCOSE IN THEENDOTHELIAL CELLS: A POTENTIAL ROLEIN THE PATHOGENESIS OF DIABETESASSOCIATED-ATHEROSCLEROSIS.X Xu, W Huang, G Rao, E Lewis, V Reddy and RPrinz, Chicago, IL. Rush University Medical CenterAbstract 111113 HEPATITIS C VIRUS CORE PROTEINUPREGULATES TELOMERASE ACTIVITY INHEPATOMA CELLS.Z Zhu, AT Wilson, K Gopalakrishna, KE Brown,BA Luxon and WN Schmidt, Iowa City, IA.University of Iowa Abstract 113Investigating Disease Modulation andIntervention115 SICKLE CELL TRAIT AND PREGNANCYASSOCIATED COMPLICATIONS.G Bansal, A Menon, S Jacob, DAnandacoomarswamy, D Godkar and SNiranjan, Brooklyn, NY. Coney Island HospitalAbstract 115117 LOVENOX, METFORMIN ANDPREVENTION OF RECURRENTPREGNANCY LOSS AND SPONTANEOUSABORTION.G Boobilli, C Glueck and P Wang, Cincinnati,OH. Jewish Hospital Abstract 117119 INTEGRIN β4 MEDIATES THEATTENUATION OF LPS-INDUCEDENDOTHELIAL CELL INFLAMMATORYRESPONSES BY SIMVASTATIN.W Chen and JR Jacobson, Chicago, IL. Universityof Chicago (Trainee Travel Award, K Award Grant Winner andMWAFMR Centocor Scholar’s Award Winner) Abstract 119121 ROLE OF THE MAPK CASCADE IN ARODENT MODEL OF PULMONARYHYPERTENSION.AA Desai, L Moreno-Vinasco, M Gomberg-Maitland, M Maitland, PA Singleton, S Sammani,S Ma, AN Husain, L Sam, Y Liu, RM Lang, MJRatain, YA Lussier and JN Garcia, Chicago, IL.The University of Chicago Abstract 121123 POLYPHENOLIC-RICH FRAGARIASPP MODULATES INFLAMMATORYMARKERS AND INSULIN RESPONSETO HIGH FAT MEAL IN OVERWEIGHTMEN AND WOMEN: ANOTHER ROLEFOR PHYTONUTRIENTS IN MEDICALNUTRITION THERAPY?CL Ellis, I Edirisinghe, A Linares, T Kappagodaand B Burton-Freeman, Davis, CA and Summit-Argo, IL. University of California, DavisAbstract 123125 OXIDIZED PHOSPHOLIPIDS ATTENUATEVENTILATOR-INDUCED LUNG INJURY INMURINE MODEL.P Fu, J Xing, S Chatchavalvanich, AA Birukovaand KG Birukov, Chicago, IL. University ofChicago (Outstanding Young Investigator Award Winner)Abstract 125127 LACK OF EFFECT OF SPECIFIC THERAPYON TRANSCRIPTOMICS FROMPERIPHERAL BLOOD MONONUCLEARCELLS IN PULMONARY ARTERIALHYPERTENSION.DN Grigoryev, SC Mathai, LK Hummers, FMWigley, JG Garcia, KC Barnes and PM Hassoun,Baltimore, MD and Chicago, IL. Johns HopkinsUniversity (Trainee Travel Award Winner)Abstract 12718

2008 Combined Annual Meeting • Final Program • Mid-America Club, Chicago, IL • April 24-25, 2008129 RISTOCETIN-INDUCED AGGREGATIONOF HUMAN GPIB-α TRANSGENIC MICEIS INHIBITED BY ANTI-HUMAN GPIBαANTIBODIES IN THE PRESENCE OFHUMAN PLASMA.AY Kim, A Goel, T Biswas, J Ware and JL Miller,Chicago, IL and Little Rock, AR. The University ofChicago (Trainee Travel Award and K Award Grant Winner)Abstract 129131 IBUTILIDE CAUSES HETEROGENEITY OFREPOLARIZATION THAT CAN RESULTIN ARRHYTHMIAS IN A MODEL OFISCHEMIA.C Lin, V Ranade, J Molnar and JC Somberg,Chicago, IL and Lake Bluff, IL. Rush UniversityAbstract 131133 CHARACTERIZATION OF LUNG VASCULARDYSFUNCTION IN A MURINE MODEL OFRADIATION PNEUMONITIS.B Mathew, J Kochinsky, S Sammani, L Moreno,R Weischelbaum and J Garcia, Chicago, IL. TheUniversity of Chicago Abstract 133135 IN VIVO SIRNA SUPPRESSION OFNON-MUSCLE MLC KINASE (NMMLCK)PROTECTS FROM LPS-INDUCED ACUTELUNG INJURY.T Mirzapoiazova, S Sammani, ET Chiang, BMambetsariev, L Moreno-Vinasco and J Garcia,Chicago, IL. University of ChicagoAbstract 135137 PROBIOTIC MANIPULATION OF THEENDOGENOUS FLORA AS PROPHYLAXISFOR VENTILATOR-ASSOCIATEDPNEUMONIA.LE Morrow, Omaha, NE. Creighton University(K Award Grant Winner) Abstract 137139 NOVEL TARGETED THERAPY FORADVANCED COLORECTAL CANCER BASEDON TRANSFORMING GROWTH FACTORBETA TYPE 1 RECEPTOR GENOTYPE.MJ Pennison, KB Wisinski and B Pasche, Chicago,IL. Northwestern University Abstract 139141 INTRA-ARTICULAR BOTULINUM TOXINTYPE A (IA-BONT/A) SIGNIFICANTLYDECREASES SHOULDER PAIN IN PATIENTSWITH REFRACTORY SHOULDER ARTHRITISPAIN: A RANDOMIZED DOUBLE-BLINDPLACEBO-CONTROLLED TRIAL.JA Singh, ML Mahowald and S Noorbaloochi,Minneapolis, MN. Minneapolis VA Medical Center(K Award Grant Winner) Abstract 141143 QUANTIFICATION OF GLOBAL LEFTVENTRICULAR MECHANICALDYSSYNCHRONY USING REAL-TIME THREE-DIMENSIONALECHOCARDIOGRAPHY.K Staffey, J Martins and A Abiose, Iowa City,IA. University of Iowa Hospitals and Clinics(Trainee Travel Award Winner) Abstract 143145 RELEASE OF PRO-INFLAMMATORYMEDIATORS AND EXPRESSION OF PRO-INFLAMMATORY ADHESION MOLECULESBY ENDOTHELIAL PROGENITOR CELLS.Y Zhang, DA Ingram, LE Mead, DN Prater,MP Murphy and J Rehman, Chicago, IL andIndianapolis, IN. University of ChicagoAbstract 145Poster Listing19

2008 Combined Annual Meeting • Call for Abstracts • Mid-America Club, Chicago, IL • April 24-25, 2008Save the Date2009 Combined Annual Meetingof CSCR and MWAFMRApril 23-24, 2009Chicago, ILwww.cscr.com

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