Topical Gel: A Novel approach for drug delivery - Journal of ...
Topical Gel: A Novel approach for drug delivery - Journal of ...
Topical Gel: A Novel approach for drug delivery - Journal of ...
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Formulation...Sudhir Bharadwaj et al.ii. Methylcelluloseiii. Hydroxypropyl celluloseiv. Hydroxypropyl methyl cellulosev. Hydroxyethyl cellulose3. Synthetic polymersa. Carbomeri. Carbopol -940ii. Carbopol -934iii. Carbopol -941b. Poloxamerc. Polyacrylamided. Polyvinyl alcohole. Polyethylene and its co-polymers4. Inorganic substancesa. Aluminium hydroxideb. Bentonite5. Surfactantsa. Cetostearyl alcoholb. Brij – 961.1.3. AdvantagesThe topical administration <strong>of</strong> <strong>drug</strong> in order to achieve optimal cutaneous and percutaneous <strong>drug</strong> <strong>delivery</strong>has recently gained an importance because <strong>of</strong> various advantages :• To avoid gastrointestinal <strong>drug</strong> absorption difficulties caused by gastrointestinal pH and enzymaticactivity and <strong>drug</strong> interaction with food and drinks.• To avoid the first pass effect, that is, the initial pass <strong>of</strong> <strong>drug</strong> substance through the systemic and portalcirculation following gastrointestinal absorption, possibly avoiding the deactivation by digestive andliver enzymes.• Non-invasive and have patient compliance.• Less greasy and can be easily removed from the skin.• Economic.• Reduction <strong>of</strong> doses as compare to oral dosage <strong>for</strong>ms.• Localized effect with minimum side effects..1.1.4. Desirable Properties <strong>of</strong> <strong>Gel</strong>sa. It should be inert, compatible with other additives and non-toxic.859 J. Chem. Bio. Phy. Sci. Sec.B, 2012, Vol.2, No.2,856-867