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Objectives• Describe the epidemiology and cause ofepilepsy• Compare and contrast the pharmacokineticand pharmacodynamic characteristics ofthe first and second generationantiepileptic drugs (AEDs) in the treatmentof epilepsy• Describe pharmacologic and nonpharmacologictreatment options for thetreatment of epilepsy
Outline• Overview of the disorder• Pharmacokinetic differences between first generation AEDs• First generation AED specific adverse drug reactions (ADRs)• Pharmacokinetic differences between second generation AEDs• Second generation AED specific ADRs• New AEDs• Generic substitution• Cytochrome P450 enzymes• Broad spectrum• Mechanism of action• Drugs on the horizon• Summary
Page 1 and 2: Understanding and ManagingEpilepsyJ
Page 3: Understanding and ManagingEpilepsyS
Page 7 and 8: Incidence of Epilepsy
Page 9 and 10: Success in AED RegimensSeizure free
Page 11 and 12: Comparative Pharmacokineticsof 1st.
Page 13 and 14: Gingival Hyperplasia Inducedby Phen
Page 15 and 16: Stevens-Johnson Syndromehttp://miss
Page 17 and 18: Trabecular Bone(http://www.merck.co
Page 19 and 20: Pharmacokinetics of Newer AEDsDrug
Page 21 and 22: Drug-Specific Side Effects:Newer AE
Page 23 and 24: Levetiracetam IV - Advantages• Ca
Page 25 and 26: Pharmacokinetic Model:Keppra XR Pla
Page 27 and 28: Vigabatrin (Sabril®)• MOA: GABA-
Page 29 and 30: Benefits of Generic Antiepileptic D
Page 31 and 32: Treatment Considerations:What Would
Page 33 and 34: Current Treatment OptionsPartialGen
Page 35 and 36: What’s on the Horizon• Lamotrig
Page 37: Summary• Unrecognized drug intera

AEDs - Free CE Continuing Education online pharmacy, pharmacists

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