The Coexistence of Capgras, Fregoli and Cotard's Syndromes in an ...

150Yal›n et al.The Coexistence of Capgras, Fregoli and Cotard’s Syndromes in an Adolescent CaseArchives of Neuropsychiatry 2008; 45: 149-51Nöropsikiyatri Arflivi 2008; 45: 149-51she had not slept for the previous 2-3 days and staredmeaninglessly. She refused to eat, did not permit her parents toeat, had exaggerated fears, had thoughts that her parents andherself would be harmed, didn't recognize her parents in theprevious 2-3 days, wanted to go to her ‘real’ parents, thought thatstrangers had replaced her parents and would not cooperate.She had not had similar complaints in the past, but during theprevious 3 months she had been worrying about her academicperformance in the high school entrance exam. There were noproblems reported in her family and peer relations, she was alsodoing well academically at school.In the initial evaluation for the mental status exam, she had afearful face and was not communicating verbally. Her affect wasdull and her mood was reported as very anxious. Her attentionperiod was very short and her orientation, judgment and realitytesting were impaired. She was suffering from paranoidpersecutiondelusions and she also had a derealization anddepersonalization thought context. Additionally, her thoughtprocess and psychomotor activities were retarded.In order to differentiate the diagnosis, biochemical andendocrinological tests, electroencephalography (EEG),computerized brain tomography (CBT), magnetic resonanceimaging of brain (MRI) and pediatric neurology consultationswere carried out. There were no abnormalities reported in theneurological examination or laboratory tests. During thepatient’s stay in our unit, the most remarkable sign was herinability to recognize her parents and her delusional thoughtsthat they were not her real parents. When she was with herparents, she thought that they were doubles or fakes who hadreplaced her real parents. However, when she was on thephone with them, she did not express any suspicions aboutthem. She had delusional thoughts with a persecutory context,such as the hospital was not a real one, the medical team werenot hospital staff, everything was a play in which she wouldeventually be harmed. She also had reference delusions thatpeople were talking about and laughing at her. In addition, shehad more delusional thoughts such as that she knew some ofthe patients in the unit and members of the team, and thatactually she was dead and her soul was wandering aroundwaiting to be punished. Due to her mother’s pregnancy thepatient was over-anxious about her health.Having excluded the organic etiology, risperidonetreatment with 2 mg per day was begun and the daily dosegradually increased to 6mg/day. As there was no positivetreatment response to 6mg/day risperidone after 3 weeks, thiswas replaced with another atypical antipsychotic, olanzapine.Despite the fact that psychotic symptoms diminished, a clinicalmanic shift appeared. Valproate was added to the treatmentwhen the manic state of the patient gradually becamemanifest after commencing olanzapine. Following the additionof valproate, olanzapine was decreased while quetiapinetreatment was started and the quetiapine dose was graduallyincreased to 1500 mg per day. On discontinuing olanzapine, themanic symptoms disappeared. In the process, the patient’spsychotic symptoms recovered significantly and eventually shewas discharged without any symptoms.DiscussionDuring the treatment period in the unit, it was observed thatour patient had symptoms of Capgras, Cotard and FregoliSyndromes. The main clinical characteristics of the Capgrassyndrome is a delusional belief that familiar persons arereplaced by strangers (2).The patient refers to some small,misinterpreted physical and behavioral differences in her mindto differentiate the familiar persons from strangers (3). Whenpatients are questioned about their delusional ideas, they findthem unbelievable and weird, but these delusional thoughtscontinue (2). The most dominant delusional thought in our casewas that strangers had taken the place of her parents. Shemaintained that her visitors (real parents) looked the same as herparents, but their behavior and way of looking were different andshe insisted on seeing her real parents.The Cotard syndrome is characterized by delusionalthoughts of denying one’s own existence or particular parts ofhis/her body (5, 9). In the literature, 89% of the cases haddepressive symptoms, 69% had nihilistic delusions about theirexistence, 65% had anxiety symptoms, and 63% had feelings ofguilt (5). Our patient said that she had died and didn’t exist.Meanwhile, she thought this was all her fault and kept apologizing.She was suffering from significant anxiety regarding herdelusional experiences and her mother’s state of health.In the Fregoli syndrome, patients have delusional beliefs thatthey know quite unfamiliar persons and places very well. Theycan perceive the hospital room as their home, or a stranger astheir relative (4). Our case believed that some patients in the unitwere her parents and some of the staff were her relatives.Especially in the Capgras Syndrome, there are someadditional symptoms such as seen in our case. Paranoid ideas,derealization and depersonalization are the frequentdisturbances (1, 7). One study found 83% paranoid delusions and43% derealization and depersonalization in Capgras syndromecases (7).Although initial studies found that these syndromes wererare, subsequent investigations showed that they were morefrequent. A study conducted in an acute psychiatric servicefound that the Capgras syndrome rate was 2.5% and in anotherstudy which evaluated the previous 5 years of patients’ recordsin a university hospital, the rate was 1.3% (6, 7). This syndromecan affect both genders at all ages (6). However, some authorsfound that it was more frequent in women (2).Berios et al reviewed the literature since 1955 and reported100 Cotard syndrome cases. The average age of these caseswas 52 years and the youngest patient was 16 years (5). Asreported in the literature, the Cotard syndrome had a differentclinical course in young cases. Its frequency and relation withother disorders were not definite. It was reported that thesyndrome was more frequent in girls and the girl/boy ratio was12/7 (9). Mojtabei (1994) reviewed the literature in 1994 andreported 34 Fregoli syndrome cases. Their average age was 34.9years and mainly male (4).There has been no definite explanation about the etiology ofall these psychopathological conditions. In the literature, theinitial studies regarding the Capgras syndrome attributed the