Guidelines for INFECTION CONTROL POLICY - Safdarjung Hospital

Step-II : Determine the HIV STATUS Code (HIV SC)What is the HIV status of the exposure source ?HIV Negative HIV Positive Status unknown Status unknownNo PEP Low titre exposure :Asymptomatic andHigh CD 4countHigh titre exposure :Advanced AIDS,primary HIV, highviral load or low CD 4HIV SCunkonownHIV SCHIV SCStep 3 : Determine Post-Exposure Prophylaxis(PEP) RecommendationEC HIV SC PEP1 1 Consider basic1 2 Recommend basic regimen2 1 Recommend expanded regimen3 1 or 2 Recommend expanded regimen1,2,3, Unknown If exposure setting suggests risks of HIVExposure, consider basic regimenBasic Regimen : Zidovucine (AZT)-600 in divided doses (300 mg) twice a day or 200 mg (thricea day) for 4 weeks + Lamiondine (3TC)- 150 mg twice a day for 4 weeks.Expanded Regimen : Basic regimen + Indinavir-800 mg thrice a day. or any other proteaseinhibitor.Pregnancy and PEPBased on limited information, anti retroviral therapy taken during 2 nd and 3 rd trimester ofpregnancy has not caused serious side effects in mother and infants. There is very littleinformation on the safety in the 1sr trimester. If the HCW is pregnant a time of exposure toHIV, the designated authority or physician must be consulted about the use of the drugs andPEP.Dept. of Medicine & Dept. of Hesp. Waste Management, SJH41