PHA 3931 Hnr Magic Bullets McKenzie - University of Florida ...

PHA 3931Honors Seminar inPharmaceutical Research"In Search of Magic Bullets"Course CoordinatorMichael W. McKenzie, Ph.D.Senior Associate Dean for Professional AffairsProfessor, Department of Pharmacy Practice(272-6221; room G-234 Student Services Center, HPNP Complex, Health Science Center)email: McKenzie@cop.ufl.eduOffice HoursStudents may meet with the course coordinator on Mondays, Wednesdays, or Fridays after class orfrom 4-5PM or by appointment at other times. An appointment can be arranged by contacting thestaff in the Office for Student Affairs at 352-273-6217.Course Educational PhilosophyThis course does not require a background in the pharmaceutical sciences. The emphasis of thecourse is on concepts and processes. The course will not accentuate factual knowledge within thepharmaceutical sciences. This course will focus on the advantages and disadvantages of usingmedications to cure or control disease. That is, do “magic bullets” really exist?All students in the honors program, but especially students with a strong interest and/or aptitude inthe sciences, are encouraged to register for this course. The course content is meant to helpstudents with a variety of educational majors to understand many issues related to drug research,the drug approval process, the historical perspectives on the development of selected drugs, and theadvantages and disadvantages that are associated with selected medications.Students are expected to enhance their learning by attending classes and participating indiscussions. Students are expected to use appropriate English grammar in a term paper and to writeconcisely with details in response to questions on examinations.GoalsThe goals of this course include the stimulation of intellectual curiosity about issues in the pharmacyprofession and in pharmaceutical research.

ObjectivesStudents taking this course will be expected to:1. Describe the benefits of drug research in our society.2. Discuss the concept of pharmaceutical care in terms of definition andpractical applications by pharmacists.3. Explain the concept of "A Magic Bullet” in terms of definition, possibilities,and limitations.4. State the process by which a drug becomes approved by the FDA.5. Discuss several societal implications of drug research (i.e., establishmentof priorities, cost/benefit, measurement of health outcomes, regulatorypractices).6. State the real and potential adverse consequences of inappropriate druguse.7. Recognize how several drugs work as "magic bullets" in the body.9. Describe various research projects currently in progress bypharmaceutical and clinical scientists in the College of Pharmacy.Course DescriptionThis seminar course will examine selected pharmaceutical research activities by pharmacy faculty,process and issue in the development of new drugs, drug tragedies, pharmacists’ role on the healthcare team, and mechanisms of action of drugs. The course will include commentary on social issuesrelated to pharmaceutical research such as the time, expense, and testing necessary to deliver newdrugs to the public, and the need to properly monitor drug effects in patients once drugs are releasedfor general use. The course will require readings, discussions in class, and reports on assignedtopics. The course will be team taught by professors in the departments of pharmaceutics,pharmacodynamics, pharmacotherapy and translational research, and pharmaceutical outcomes andpolicyin the College of Pharmacy.ScheduleThe schedule for this course is Monday, Wednesday, and Friday (12:50 - 1:40 PM) in the HealthProfessions, Nursing, and Pharmacy Complex (HPNP) at the Health Science Center (Room G-210on Monday and Friday and Room G316 on Wednesday).

GradingLetter grades will be given to students who take this course. Academic performance will beevaluated through attendance records, exams, and a term paper. A list of topics for a term paper willbe made available to you within the first several weeks of the semester. Terms papers are dueWednesday November 30, 2011.Exams will count 65%, attendance 10%, and the term paper 25% of the course grade. The dates forexams are listed on the topic schedule. Make-up exams will be permitted under the followingconditions: the student has a reasonable excuse for missing the exam, preferably discussed at least24 hours in advance of the exam with the course coordinator; and, the make-up exam is completedwithin one week of the missed exam. An unexcused absence from an exam will result in a zeroscore for that exam. Students should notify the course coordinator at least 24 hours in advance ofan exam if they know they cannot attend due to a reasonable circumstance. Greater than fourabsences (excused/unexcused) will result in a zero score for attendance in calculating the coursegrade.The grading scale is based on an achievement of a percent of total points awarded per performancemeasure. These are: A 93 to 100%, A- 90 to

Instructor and Course EvaluationsAll students are expected to submit an instructor and course evaluation per University of Floridaprocedures.Faculty Evaluations: You will receive an email from the Curricular Affairs Office requesting thatyou complete faculty evaluations. If the course is team-taught, you will receive emails during thesemester to alert you when to evaluate the faculty members. Please complete your facultyevaluations by the specified date and time by logging in with your GatorLink account at the followingsite: https://evaluations.ufl.eduFaculty evaluations are important feedback for your course instructors and the University andreceive major consideration in the tenure and promotion process. Your input via evaluations canmake a difference in our College’s teaching activities, so participate, evaluate and our College will bebetter for it.The online faculty evaluation system is completely anonymous. When you submit an evaluation, thesystem marks that you have submitted an evaluation for the section (so you cannot submit multipleevaluations), but from that point on, there is no connection between you and the evaluation data.Faculty evaluations also provide useful information for students. The results of your evaluation inputare made available to all students in future semesters at:http://www.aa.ufl.edu/aa/evaluations/search/.Course Evaluations: In the last few weeks of the course, you will receive an email with directions forcompleting a course evaluation. Note, course evaluations provide feedback that is different from theFaculty evaluations and both are very important to continuous improvement of our program.Course evaluations are used by the College to identify how to improve the how the course isdesigned and delivered. Therefore, our Courses will be better through your completion of theseevaluations. You will complete Course Evaluations via a website that is different from FacultyEvaluations. These evaluations are also anonymous.Academic HonestyThe University of Florida Honor Code States:We the members of the University of Florida community, pledge to hold our peers andourselves to the highest standards of honesty and integrity.Students are expected to complete assignments and take quizzes with integrity. Academicdishonesty will not be tolerated. If a student commits academic dishonesty, the academic penaltywill be a failing grade in the course. The UF policies and procedures on academic dishonesty will befollowed.Students will have the opportunity to sign the following statement on all work attempted forevaluation:

On my honor, I have neither given nor received unauthorized aid on this examination.Expectations of StudentsStudents are expected to:• Be diligent and timely in studying the course material.• Be on time for class meetings.• Be prepared for class or group discussions.• Do your own work.• Actively collaborate with peers when assigned to groups.• Inform the course coordinator about an absence from an exam or other assigned classactivity at least 24 hours prior to the event.• Dress appropriately for class.• Turn off cell phones and other electronic communication devices during a lecture ordiscussion.• Be quiet during lectures or peer presentations.• Be focused and avoid distractive behaviors in class.• Appropriately use the computer in class, i.e., do not be looking at unrelated informationon the web site during class.• Participate in class or group discussions.• Raise one’s hand to be recognized before making a comment in class.• Be respectful to the teacher.• Be respectful to fellow students in discussions.• Be courteous, respectful, and civil when using email communications.• Address faculty with the appropriate title and name, i.e., Dr. (last name) or Professor(last name).• Address concerns about performance or course material directly with the coursecoordinator.• Seek assistance with academic or personal difficulties as soon as possible.AccommodationsStudents requesting classroom accommodation must first register with the Dean of Students Office.The Dean of Students Office will provide documentation to the student who must then provide thisdocumentation to the Instructor when requesting accommodation.Students should present their accommodation letter at the beginning of the semester soarrangements can be made well ahead of time. Students have the option to implementaccommodations or waive them. Information about the Disability Resources Center can be accessedat: http://www.dso.ufl.edu/drc/current.php andhttp://www.dso.ufl.edu/drc/documents/semester_checklist_070102.pdf.

Counseling and Student HealthStudents who are experiencing issues and events that could adversely affect academic performanceand personal health are encouraged to meet with the course coordinator for guidance. Students maycontact the UF Counseling and Wellness Center 352-392-1575; http://www.counseling.ufl.edu). Thetelephone number for the Alachua County the Crisis Center number is 352-264-6789.

PHA 3931Honors Seminar in Pharmaceutical Research"In Search of Magic Bullets"List of TopicsFall Semester 2011Course CoordinatorMichael W. McKenzie, Ph.D.Senior Associate Dean for Student AffairsProfessor of Pharmacy Practice(273-6221, Room G-234 HPNP Complex, Health Science Center)(email: Mckenzie@cop.ufl.edu)Schedule: Mondays-Wednesdays-Fridays 12:50 to 1:40 PMRoom: G-210 on Monday and Fridays and G-316 on Wednesdays in the HPNP Complex, HealthScience CenterDate Day Topic Instructor8/22 Mon. Orientation/What Are Magic Bullets? McKenzie8/24 Wed. What Are Magic Bullets? McKenzie8/26 Fri. Paul Ehrlich – Father of Chemotherapy McKenzie8/29 Mon. Domagk and Fleming – Sulfanilamide McKenzieand Penicillin8/31 Wed. Aspirin – A Magic Bullet withMultiple Uses9/2 Fri. Animals in Drug Research -Roles and ProtectionsMcKenzieKatovich9/5 Mon. Labor Day Holiday – No Class9/7 Wed. Drug Tragedies McKenzie9/9 Fri. Drug Tragedies McKenzie9/12 Mon. Ethical Considerations in Researchfor Magic BulletsMcKenzie

9/14 Wed. Bringing a MB to Market McKenzie9/16 Fri. Bringing a MB to Market McKenzie9/19 Mon. Herbal Medicines, Vitamins,and Supplements as Magic Bullets?McKenzie9/21 Wed. Review for Exam #1 McKenzie9/23 Fri. Exam #1 McKenzie9/26 Mon. Pharmaceutical Care: Impact onUse of MedicationsSegal9/28 Wed. Marijuana: A Magic Bullet? McKenzie9/30 Fri. MBs for Epilepsy Riffee10/3 Mon. MBs for Epilepsy Riffee10/5 Wed. The Challenge of Alcoholism – Cana Magic Bullet Be Found?Peris10/7 Fri. MBs for Clots Lopez10/10 Mon. MBs for Migraine Vogel-Anderson10/12 Wed. MBs for Diabetes Mellitus Whalen10/14 Fri. MBs for Diabetes Mellitus Whalen10/17 Mon. MBs for Pain McKenzie10/19 Wed. New Approaches to ControlCardiovascular DiseaseKatovich10/21 Fri. MBs for Allergic Rhinitis Hendeles10/24 Mon. TBA10/26 Wed. Review for Exam #210/28 Fri. Exam #2 McKenzie0/31 Mon. MBs for Cancer Richards11/2 Wed. MBs for Cancer Richards

11/5 Fri. Homecoming – No Class11/7 Mon. MBs for Acute Otitis Media McKenzie11/9 Wed. MBs for HIV Inge11/11 Fri. Veterans Day – No Class11/14 Mon. Vaccines as MBs McKenzie11/17 Wed. Vaccines as MBs McKenzie11/18 Fri. MBs – Take with or without Food? Derendorf11/21 Mon. Growth Hormone as a MB Millard11/23 Wed. No Class11/25 Fri. No Class – Thanksgiving Holidays11/28 Mon. MBs for Some but Not All?Pharmacogenomics and DrugResponseMoore11/30 Wed. Term Paper Presentations* McKenzie12/2 Fri. Term Paper Presentations McKenzie12/5 Mon. Review and Discussion McKenzie12/7 Wed. Exam #3 McKenzie*All term papers are due on this date.

FACULTYPHA 3931 Honors Seminar: In Search of Magic BulletsMichael McKenzie, Ph.D., R.Ph.Senior Associate Dean for Professional Affairs and Professor, Department of Pharmacotherapy and TranslationalResearchRichard Segal, Ph.D., R.Ph.Professor and Chairman, Department of Pharmaceutical Outcomes and PolicyMichael Katovich, Ph.D.Professor, Department of PharmacodynamicsWilliam Riffee, Ph.D., R.Ph.Dean and Professor, Department of PharmacodynamicsAshley Richards, Pharm.D., R.Ph.Clinical Specialist in Oncology, Department of Pharmacy Services,Shands Hospital in GainesvilleLisa Inge, PharmD, R.Ph.Clinical Associate ProfessorDepartment of Pharmacotherapy and Translational ResearchWilliam Millard, Ph.D.Executive Associate Dean, Associate Dean for Research and Graduate Studies, andProfessor, Department of PharmacodynamicsLeslie Hendeles, Pharm.D., R.Ph.Professor, Department of Pharmacotherapy and Translational Research, College of Pharmacy, and Department ofPediatrics, College of MedicineHartmut Derendorf, Ph.D.Distinguished Professor & Chairman, Department of Pharmaceutics and Director, Center for Drug Interactions andEducationLarry Lopez, Pharm.D., BCPS, R.Ph.Professor and Interim Chair, Department of Pharmacotherapy and Translational Research, College of Pharmacy, andDepartment of Cardiology, College of MedicineKatherine Vogel Anderson, PharmD., R.Ph.Clinical Assistant ProfessorDepartment of Pharmacotherapy and Translational ResearchJoanna Peris, Ph.D.Associate Professor, Department of PharmacodynamicsKaren Whalen, Pharm.D., CDE, R.Ph.Clinical Associate ProfessorDepartment of Pharmacotherapy and Translational ResearchMariellen Moore, Pharm.D., R.Ph.Graduate Student, Center for Pharmacogenomics and Departments of Pharmaceutics and Pharmacotherapy andTranslational Research