Micro-Reactor Technology (MRT) A continuous reactor system for ...

Mobile UnitThe mobile modular units offer the possibility to be used atboth locations: lab & kilo-lab alike. The same equipment &parameter set can thereby be used for both development ofthe process and subsequent kg production. As a result no‘scale-up effects’ are envisaged.KilogramsJust let it run a couple of hours and you get your kilogramquantities. Quality attributes of the product remain identicalat lab and kilo-lab. Variability all along the runs is minimized.Schema Siegfried Examplesa. Aromatic boronic acidb. Metalorganic reaction (double de-protonation)c. Pinacolato-dichloromethylborane formationd. Demethylation of MeO-Aryle. Nitration of an aromatic systemf. Epoxide opening with ammoniag. Multi-step sequence; deprotonation,silylation, alkylation, hydrolysish. α-Alkylation of a carboxylic acidi. O-Nitration of an aromatic alcoholj. Mono-nitration of an aliphatic diolNitration of an aliphatic alcoholk. Ammonolysis of an esterl. Oxidation with hydrogen peroxide