GATA2 mutations screening is recommended prior to ... - CBMTG
GATA2 mutations screening is recommended prior to ... - CBMTG
GATA2 mutations screening is recommended prior to ... - CBMTG
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Loss of function or dominant negative?• Mice <strong>GATA2</strong> m /<strong>GATA2</strong> wt :defects in granulocytemacrophageprogeni<strong>to</strong>rsRodrigues et al., Blood 2008• Somatic <strong>mutations</strong> reported in CML patients inblastic cr<strong>is</strong><strong>is</strong>Zhang et al., Leuk. Res. 2009• High levels of <strong>GATA2</strong> expression are associated withpoor prognos<strong>is</strong> in pediatric AMLLuesink et al., Blood, 2012Vincente et al., Crit. Rev. Oncol, Hema<strong>to</strong>l, 2011
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