Guidelines for intensified tuberculosis case-finding and isoniazid ...
Guidelines for intensified tuberculosis case-finding and isoniazid ...
Guidelines for intensified tuberculosis case-finding and isoniazid ...
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
GRADE profile table 8: Duration of IPT in adults INH 6 months vs 12 monthsin those with any TST statusBibliography: Pape et al. 1993; Whalen et al. 1997; Hawken et al. 1997; Mwinga et al. 1998; Fitzgerald et al. 2001; Gordinet al. 1997; Rivero et al. 2003; Whalen et al.1997 – anergyNo. ofstudies8Quality assessmentDesign Limitations Inconsistency Indirectness Imprecision OtherconsiderationsActive TB--possible, probable, confirmed (follow up 1–3 years; clinical assessment, chest X-ray, sputum <strong>for</strong> AFB)R<strong>and</strong>omized trialsVery seriousNo seriousinconsistencyNo seriousindirectnessNo seriousimprecisionNoneConfirmed TB (follow up 1–3 years; culture-proven)0No evidenceavailableNoneMortality (any cause) (follow up 1–3 years; review of hospital records <strong>and</strong> patients’ files)2R<strong>and</strong>omized trialsVery seriousNo seriousinconsistencyNo seriousindirectnessNo seriousimprecisionNoneHIV disease progression0No evidenceavailableNoneAdverse drug reactions leading to treatment interruption (follow up 1–3 years; laboratory monitoring <strong>and</strong> clinical assessment)12R<strong>and</strong>omized trialsVery seriousNo seriousinconsistencyNo seriousindirectnessNo seriousimprecisionNone1Not estimable due to the lack of events in the 12 months’ group.42