Nicotrol Patient Brochure - PfizerPro

VALUABLE COUPON INSIDEWhen you’re ready to sayI’m a“ quitter”NICOTROL Inhaler may help you quit smoking.Talk with your doctor and find out if the inhaleris right for you.NICOTROL ® Inhaler (nicotine inhalation system)is indicated as an aid to smoking cessation for the reliefof nicotine withdrawal symptoms. It is available onlyby prescription and is recommended for use as part of acomprehensive behavioral smoking cessation program.Important Safety InformationDo not use the NICOTROL Inhaler if you arehypersensitive or allergic to nicotine, menthol,or to any ingredient in the product.Please see full Prescribingand Patient Information forNICOTROL Inhaler insidepocket and Important SafetyInformation on pages 12-13.Help put the power to quitin your hands.

The benefits of quittingQuitting is not easy. But here are just a few ofthe many benefits to look forward to once you’resmoke free:✔ 1 to 9 months after quitting, coughing andshortness of breath decrease✔ Your stroke risk may be reduced to that ofa nonsmoker✔ You won’t have to spend money on cigarettesThinking aboutquitting?Talk to your doctorTalk to your doctor when you’re readyLet your doctor know when you want to quitsmoking. He or she can help you start a quit plan.If you need medicine to help you quit smoking,your doctor will decide what is right for you.✔ 63% of smokers said that advice from a doctormakes them think more seriously about quittingsmoking*A special note about children and pets: TheNICOTROL Inhaler can cause serious illness orbe fatal in children and pets—even in very smallamounts. If a child chews on or swallows new orused NICOTROL Inhaler cartridges, immediatelycall a doctor or call your regional poison center.* The results of an American Legacy Foundation smoking survey. Responsesto an online survey of 2037 adult smokers conducted from November 13,2008, through December 12, 2008, in the United States. Responses to thequestion, “Did this advice from your health care provider (doctor, nurse,nurse practitioner, or physician assistant) make you think more seriouslyabout quitting?” Response options: “yes” or “no.”www.NICOTROL.comPlease see full Prescribing and Patient Informationfor NICOTROL Inhaler inside pocket andImportant Safety Information on pages 12-13.Help put the power to quitin your hands.2GLUE STRIP3

What is nicotinereplacementtherapy?The specific effects of the NICOTROL Inhalertreatment on fetal development and nursing infantsare unknown. Therefore, pregnant and nursingSomething to think aboutusingTheeducationalAmericanandLungbehavioralAssociationinterventionssaysbefore using pharmacological approaches.using NRT can double a smoker’s chanceSideofeffectsquittingassociatedversus goingwithcoldtheturkey!NICOTROL Inhaler:You are likely to experience mild irritation ofthe mouth or throat, or cough when you firstNicotine use the NICOTROL replacement Inhaler. therapy In clinical (NRT) trials,is the an frequency aid to of help mouth you or quit throat smoking irritation, orsmokers should be encouraged to attempt cessationcoughing declined with continued use. The mostDid common you know nicotine-related that NRTs: side effect was upset✔ stomach. Take the Other place nicotine-related of from side cigarettes effects werenausea, diarrhea, and hiccup. Smoking-related✔ side Do effects not have included the cancer-causing chest discomfort, agents bronchitis, or toxicand gases high that blood are in pressure. cigarette smokeIt is important to tell your doctor about any other✔ Work best when you have a quit plan andmedications you may be taking because they mayneed get dosage counseling adjustment.✔ Terms Come and in several Conditions forms like of inhalers, couponpatches,Eligibility and Criteria: gums1. This coupon is not valid for prescriptions that are eligible tobe reimbursed, in whole or in part, by Medicaid, Medicare, or other federal or statehealthcare programs (including any state prescription drug assistance programsSmokers and the Government may Health benefit Insurance from Plan available an NRT in Puerto when Rico [formerly they knownas “La Reforma de Salud”]). This coupon is not valid for prescriptions that aretry eligible to to quit. be reimbursed If you by private think insurance NRT plans can or other help health you or pharmacy quitbenefi t programs which reimburse you for the entire cost of your prescription drugs.smoking, talk to your doctor today.2. Coupon is limited to $35 or the amount of your co-pay, whichever is less. Offerlimited to $420 per patient per year. 3. You must deduct the value of this couponfrom any reimbursement request submitted to your insurance plan, either directly byImportant you on your behalf. Safety 4. This Informationcoupon is not valid residents of Massachusettswhose prescriptions are covered in whole or in part by third-party insurance, orIf where you otherwise have prohibited cardiovascular, by law. Coupon cannot peripheral be combined vascular, with any other orrebate/coupon, free trial, or similar offer for the specifi ed prescription. 5. Offer goodbronchospastic only in the US and Puerto diseases Rico. Coupon including is limited to 1 per asthma prescription or during chronic thisoffering period and not transferable. 6. Pfi zer reserves the right to rescind, revoke,pulmonary or amend this offering disease, without notice. talk to your doctor aboutNot available through mail order. No membership fees required.using the NICOTROL Inhaler. If you are underThis coupon is not health insurance.a This doctor’s coupon care is accepted for any only condition, at participating you pharmacies. should firstdiscuss For any questions, with please your call doctor 1-877-465-6437. the potential Pfi zer Inc, 235 East risks 42nd of Street, usingNew York, NY 10017this product.www.pfi zer.com4www.NICOTROL.comPlease see full Prescribing and Patient Informationfor NICOTROL Inhaler inside pocket andImportant Safety Information on pages 12-13.Help put the power to quitin your hands.13 5

The NICOTROL Inhaler can help put thepower to quit right in your hand. When used aspart of a complete behavioral smoking cessationprogram, it can curb your urge to smoke. Theinhaler may provide some degree of comfortby providing a hand-to-mouth ritual similar tosmoking. The importance of this effect in quittingsmoking isn’t known.In fact, the NICOTROL Inhaler hasbeen proven toIncrease quit rates✔ Increased quit rates by 44% and 45% comparedwith 23% and 14% in the control groups at6 weeks in 2 clinical studiesReduce cravings✔ In 1 of the 2 studies mentioned above,it also reduced the urge to smoke throughoutthe first week*NICOTROL Inhaler —(nicotine inhalation system)Kick thesmoking habitImportant Safety InformationBecause nicotine is addictive, it is possible tobecome dependent on the NICOTROL Inhaler.It is important to use it only for as long as neededto overcome your smoking habit. The safety oftreatment with the NICOTROL Inhaler for periodslonger than 6 months has not been established,and such use is not recommended.* In 1 of the 2 trials with a total of 222 healthy patients. The number ofNICOTROL Inhaler cartridges used was a minimum dosage of 4 cartridgesper day.6www.NICOTROL.comPlease see full Prescribing and Patient Informationfor NICOTROL Inhaler inside pocket andImportant Safety Information on pages 12-13.Help put the power to quitin your hands.7

Using the NICOTROL InhalerA nicotine vapor cartridge is piercedwhen put into the inhaler.The NICOTROL Inhaler is athin plastic mouthpiece witha nicotine cartridge inside.One cartridge lasts about 20 minutes withcontinuous puffing.Each cartridge delivers 4 mg of nicotine butonly 2 mg is actually absorbed (similar to theamount of nicotine from 2 cigarettes).How much nicotine?In the cartridgeInhaled over 5 minutes of puffingAbsorbed in the body10 mg4 mg2 mg(equivalent to~2 cigarettes)✔ The cartridge is inserted into the mouthpiece✔ When you puff on the mouthpiece, the cartridgedelivers nicotine in the form of a vapor✔ Nicotine in cartridges is used up after about20 minutes of active puffing✔ Try different schedules to help control cravings.Puffing for 5 minutes at a time will give youenough nicotine for 4 uses. In a few days you’llfind what works best and know when nicotinein cartridges is used up✔ The mouthpiece of the inhaler is reusable, butthe plastic cartridge containing the drug is notA special note about children and pets:The NICOTROL Inhaler can cause serious illnessor be fatal in children and pets—even in very smallamounts. If a child chews on or swallows new orused NICOTROL Inhaler cartridges, immediatelycall a doctor or call your regional poison center.Something to think aboutOne year after you quit smoking,the added risk of heart disease drops tohalf of what it is for smokers.8www.NICOTROL.comPlease see full Prescribing and Patient Informationfor NICOTROL Inhaler inside pocket andImportant Safety Information on pages 12-13.Help put the power to quitin your hands.9

Tips to help you quitTalk to your doctorTalk to your doctor about your quittingplan. If you’re concerned aboutwithdrawal symptoms, ask your doctorabout the NICOTROL Inhaler.Change your habits slowlyIf you focus on getting healthywhen you try to quit, you may wantto improve your eating habits. Butchanging them too quickly may addto the stress as you try to quit. Tryto eat healthy foods such as grains,vegetables, fruits, and fish. Andeat fewer high-fat, high-sugar,low-nutrient foods.Think about your drinksTo resist temptation, try to avoiddrinks that you associate with smoking.Drink lots of water instead.ExerciseIt’s also important to exercise. It mayhelp you to control your weight as youtry to quit. But be sure to consult yourdoctor before starting any new exerciseprogram.Important Safety InformationThe specific effects of the NICOTROL Inhalertreatment on fetal development and nursing infantsare unknown. Therefore, pregnant and nursingsmokers should be encouraged to attempt cessationusing educational and behavioral interventionsbefore using pharmacological approaches.You are encouraged to report negative sideeffects of prescription drugs to the FDA.Visit www.fda.gov/medwatch or call1-800-FDA-1088.10www.NICOTROL.comPlease see full Prescribing and Patient Informationfor NICOTROL Inhaler inside pocket andImportant Safety Information on pages 12-13.Help put the power to quitin your hands.11

Product Indication and SafetyInformationNICOTROL ® Inhaler (nicotine inhalation system)is indicated as an aid to smoking cessation forthe relief of nicotine withdrawal symptoms. It isavailable only by prescription and is recommendedfor use as part of a comprehensive behavioralsmoking cessation program.Important Safety InformationDo not use the NICOTROL Inhaler if you arehypersensitive or allergic to nicotine, menthol,or to any ingredient in the product.If you have cardiovascular, peripheral vascular, orbronchospastic diseases including asthma or chronicpulmonary disease, talk to your doctor about usingthe NICOTROL Inhaler. If you are under a doctor’scare for any condition, you should first discuss withyour doctor the potential risks of using this product.You should stop smoking completely before usingthe NICOTROL Inhaler. You should not smoke oruse other nicotine-containing products while undertreatment with the NICOTROL Inhaler.What is nicotineBecause nicotine is addictive, it is possible tobecome dependent on the NICOTROL Inhaler.It is important to use it only for as long as neededto overcomereplacementyour smoking habit. The safety oftreatment with the NICOTROL Inhaler for periodslonger than 6 months has not been established,and such use is not recommended.therapy?A special note about children and pets:The NICOTROL Inhaler can cause serious illnessor be fatal in children and pets—even in very smallamounts. If a child chews on or swallows new orused NICOTROL Inhaler cartridges, immediatelycall a doctor or call your regional poison center.The specific effects of the NICOTROL Inhalertreatment on fetal development and nursing infantsare unknown. Therefore, pregnant and nursingsmokers should be encouraged to attempt cessationusing educational and behavioral interventionsbefore using pharmacological approaches.Side effects associated with theNICOTROL Inhaler:You are likely to experience mild irritation ofthe mouth or throat, or cough when you firstuse the NICOTROL Inhaler. In clinical trials,the frequency of mouth or throat irritation, orcoughing declined with continued use. The mostcommon nicotine-related side effect was upsetstomach. Other nicotine-related side effects werenausea, diarrhea, and hiccup. Smoking-relatedside effects included chest discomfort, bronchitis,and high blood pressure.It is important to tell your doctor about any othermedications you may be taking because they mayneed dosage adjustment.Terms and Conditions of couponEligibility Criteria: 1. This coupon is not valid for prescriptions that are eligible tobe reimbursed, in whole or in part, by Medicaid, Medicare, or other federal or statehealthcare programs (including any state prescription drug assistance programsand the Government Health Insurance Plan available in Puerto Rico [formerly knownas “La Reforma de Salud”]). This coupon is not valid for prescriptions that areeligible to be reimbursed by private insurance plans or other health or pharmacybenefi t programs which reimburse you for the entire cost of your prescription drugs.2. Coupon is limited to $35 or the amount of your co-pay, whichever is less. Offerlimited to $420 per patient per year. 3. You must deduct the value of this couponfrom any reimbursement request submitted to your insurance plan, either directly byyou or on your behalf. 4. This coupon is not valid for residents of Massachusettswhose prescriptions are covered in whole or in part by third-party insurance, orwhere otherwise prohibited by law. Coupon cannot be combined with any otherrebate/coupon, free trial, or similar offer for the specifi ed prescription. 5. Offer goodonly in the US and Puerto Rico. Coupon is limited to 1 per prescription during thisoffering period and is not transferable. 6. Pfi zer reserves the right to rescind, revoke,or amend this offering without notice.Not available through mail order. No membership fees required.This coupon is not health insurance.This coupon is accepted only at participating pharmacies.For any questions, please call 1-877-465-6437. Pfi zer Inc, 235 East 42nd Street,New York, NY 10017www.pfi zer.comwww.NICOTROL.comPlease see full Prescribing and Patient InformationPlease for NICOTROL see full Prescribing Inhaler and inside Patient pocket Information andImportant for NICOTROL Safety Information Inhaler inside on pages pocket. 12-13.12 4Help put the power to quitin your hands.13

Put savings in your hands alongwith the power to help quit smokingVisit www.NICOTROL.com to download andprint more couponsSAVEup to$35instantly*Save on your next Nicotrol Inhaler prescriptionHow to use this coupon:1. Hand the Pharmacist your prescriptionwith this coupon.These savings are good when presented witha valid, signed prescription for NICOTROL.No substitutions permitted.2. Save up to $35 on your NICOTROLprescription instantly.3. Also available on refills.This coupon is not health insurance.*See Terms and Conditions on back.✔ Eligible patients can save up to $35 on eachNICOTROL Inhaler prescription (new or refill)with the NICOTROL savings coupon** See Terms and Conditions on page 13.Important Safety InformationYou are likely to experience mild irritation of themouth or throat, or cough when you first use theNICOTROL Inhaler. In clinical trials, the frequencyof mouth or throat irritation, or coughing declinedwith continued use. The most common nicotinerelatedside effect was upset stomach. Other nicotinerelatedside effects were nausea, diarrhea, and hiccup.Smoking-related side effects included chest discomfort,bronchitis, and high blood pressure.Please see full Prescribing and Patient Informationfor NICOTROL Inhaler inside pocket.Need help paying forPfizer medicines?Pfizer has programsthat can help. Call1-866-706-2400 or visitwww.PfizerHelpfulAnswers.comHelp put the power to quitin your hands.NCU00092/285165-01 © 2011 Pfi zer Inc. All rights reserved. Printed in USA/May 2011

”.fa.itSave on your next Nicotrol Inhaler prescriptionHow to use this coupon:SAVE2. Save up to $35 on your NICOTROLprescription instantly.1. Hand the Pharmacist your prescriptionwith this coupon.3. Also available on refills.These savings are good when presented witha valid, signed prescription for NICOTROL.No substitutions permitted.up to$35instantly*This coupon is not health insurance.*See Terms and Conditions on back.B:9.5”T:9”By using this coupon, you acknowledge that you currently meet the eligibility criteria and will comply with the terms and conditions described below:Eligibility Criteria: 1. This coupon is not valid for prescriptions that are eligible to be reimbursed, in whole or in part, by Medicaid, Medicare, or other federal or state healthcare programs (including any state prescription drug assistanceprogram and the Government Health Insurance Plan available in Puerto Rico [formerly known as “La Reforma de Salud”]). This coupon is not valid for prescriptions that are eligible to be reimbursed by private insurance plans or other healthor pharmacy benefi t programs that reimburse you for the entire cost of your prescription drugs. This coupon is not health insurance. 2. Coupon is limited to $35 or the amount of your co-pay, whichever is less. Offer limited to $420per patient per year. 3. You must deduct the value of this coupon from any reimbursement request submitted to your insurance plan, either directly by you or on your behalf. 4. This coupon is not valid for residents of Massachusetts whoseprescriptions are covered in whole or in part by third-party insurance, or where otherwise prohibited by law. Coupon cannot be combined with any other rebate/coupon, free trial, or similar offer for the specifi ed prescription. 5. Offer good only in theU.S. and Puerto Rico. Coupon is limited to 1 per prescription during this offering period and is not transferable. 6. Pfi zer reserves the right to rescind, revoke, or amend this offering without notice. Not available through mail order.This coupon will be accepted only at participating pharmacies.To the Pharmacist for a patient paying cash: Submit claim to Therapy First. A valid Other Coverage Code is required. Patient payment will be reduced by $35.00. You’ll receive this in your reimbursement from Therapy First plus a handling fee.To the Pharmacist for a patient with an Authorized Third Party: Submit claim to Primary Third Party Payer fi rst, then submit the balance due to Therapy First as a Secondary Payer as a co-pay only billing, using other Coverage Code Indication. Paymentwill be reduced by $35.00. You’ll receive this in your next reimbursement from Therapy First plus a handling fee.Submit this claim/information to Therapy First:Bin Number: 004682 RxPCN: CN Group ID: XXXXXXXX Cardholder ID: XXXXXXXFor any questions regarding Therapy First online processing, please call the Help Desk at 1-800-422-5604.I agree to the terms and conditions received with this coupon. No membership fees.For any questions, please call Customer Service at 1-877-465-6437. Pfizer Inc, 235 East 42nd Street, New York, NY 10017www.pfizer.comThis offer expires 03/31/12.NCU00092A ©2011 Pfi zer Inc. All rights reserved. Printed in USA/March 2011