Supplementary Information Rank Prob (t-test ... - UCLA-DOE
Supplementary Information Rank Prob (t-test ... - UCLA-DOE
Supplementary Information Rank Prob (t-test ... - UCLA-DOE
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<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description1 1.87E-06 3.98 up Mm.6853 Sprr2a 101025_f_at AJ005559 small proline-rich protein 2A2 7.56E-06 3.52 down Mm.21762 1200006L06Rik 160144_at AW046006 RIKEN cDNA 1200006L06 gene3 7.82E-06 2.96 down Mm.29431 1810014L12Rik 95137_at AI852985 RIKEN cDNA 1810014L12 gene4 1.51E-05 2.24 down Mm.30251 Mm.30251 97451_at AI837599 Mus musculus, clone MGC:7535 IMAGE:3492270, mRNA, complete cds5 1.99E-05 5.06 down Mm.3520 Nkx3-1 97157_at U88542 NK-3 transcription factor, locus 1 (Drosophila)6 2.34E-05 3.01 down Mm.177724 2810484M10Rik 100633_at AW124268 RIKEN cDNA 2810484M10 gene7 2.63E-05 2.90 down Mm.4381 Satb1 99665_at U05252 special AT-rich sequence binding protein 18 2.70E-05 3.14 up Mm.878 Ly6d 160553_at X63782 lymphocyte antigen 6 complex, locus D9 4.30E-05 2.34 down Mm.2815 1110021H02Rik 97807_at AI838630 RIKEN cDNA 1110021H02 gene10 4.30E-05 3.59 down Mm.27066 Phyh 96608_at AF023463 phytanoyl-CoA hydroxylase11 4.48E-05 2.07 down Mm.4234 Fkbp2 99546_at M77831 FK506 binding protein 2 (13 kDa)12 4.50E-05 2.61 up Mm.35439 Sparc 97017_f_at AW214439 secreted acidic cysteine rich glycoprotein13 7.20E-05 1.98 down Mm.30000 1110029F20Rik 160376_at AW125508 RIKEN cDNA 1110029F20 gene14 7.24E-05 2.97 down Mm.18830 Mm.18830 103412_at AI847230 ESTs, Weakly similar to LOMP protein [H.sapiens]15 7.39E-05 3.95 down Mm.1186 Car2 92642_at M25944 carbonic anhydrase 216 8.02E-05 2.75 down Mm.28366 Ide 160290_at AI574278 insulin degrading enzyme17 8.26E-05 3.42 up Mm.2873 Mm.2873 161558_f_at AV263411 ESTs18 9.58E-05 2.62 down Mm.27606 1200002G13Rik 96708_at AW120643 RIKEN cDNA 1200002G13 gene19 0.00011 2.72 down Mm.2621 Aldh2 96058_s_at U07235 aldehyde dehydrogenase 2, mitochondrial20 0.00011 2.03 up Mm.21440 Dpp7 104036_at AI845447 dipeptidyl peptidase 721 0.00011 1.89 down Mm.147685 Erp44-pending 96773_at AW125408 endoplasmic reticulum resident protein 44kDa22 0.00013 3.26 down Mm.25777 Inpp5b 94398_s_at AF040094 inositol polyphosphate-5-phosphatase, 75 kDa23 0.00013 2.80 down Mm.6250 Prom 93389_at AF039663 prominin24 0.00014 2.30 down Mm.7339 Cldn4 101410_at AB000713 claudin 425 0.00014 2.02 down Mm.30103 1110014L17Rik 96894_at AW122685 RIKEN cDNA 1110014L17 gene26 0.00015 2.58 up Mm.21657 AW322500 103456_at AI841800 expressed sequence AW32250027 0.00016 2.88 down Mm.21793 2310005G07Rik 104087_at AI840598 RIKEN cDNA 2310005G07 gene28 0.00016 2.36 down Mm.507 D8Bwg1414e 98849_at AI463656 DNA segment, Chr 8, Brigham & Women's Genetics 1414 expressed29 0.00019 1.83 down Mm.4551 Vil2 100084_at X60671 villin 230 0.00023 2.23 down Mm.16453 Pxmp3 103047_at AF031128 peroxisomal membrane protein 3, 35 kDa31 0.00023 3.03 up Mm.45561 3000001O05Rik 160105_r_at AI847033 RIKEN cDNA 3000001O05 gene32 0.00023 2.59 down Mm.25743 Tmprss2 103974_at AI005782 transmembrane protease, serine 233 0.00023 2.93 down Mm.24441 Mm.24441 103743_at AI851348 ESTs34 0.00024 3.62 down Mm.116862 3300002C04Rik 103686_at AA874490 RIKEN cDNA 3300002C04 gene35 0.00025 1.78 up Mm.22505 Hsd17b12 94276_at AF064635 hydroxysteroid (17-beta) dehydrogenase 1236 0.00026 2.01 up Mm.22525 2310014H01Rik 104341_at AW121406 RIKEN cDNA 2310014H01 gene37 0.00026 2.34 down Mm.196477 5730450N06Rik 104627_at AW121668 RIKEN cDNA 5730450N06 gene38 0.00026 1.99 up Mm.129578 Mm.129578 161129_r_at AA144272 Mus musculus, Similar to BCL2-associated athanogene 2, clone MGC:2878639 0.00026 3.21 down Mm.182227 4931406C07Rik 96090_g_at AI255972 RIKEN cDNA 4931406C07 gene40 0.00027 2.26 up Mm.20156 2610042F04Rik 103606_r_at AW121438 RIKEN cDNA 2610042F04 gene41 0.00028 2.82 down Mm.182959 1700015E05Rik 94207_at AI842377 RIKEN cDNA 1700015E05 gene42 0.00029 1.48 down Mm.41680 Mapbpip-pending 99164_at AI844560 mitogen activated protein binding protein interacting protein43 0.00030 2.75 down Mm.28614 1600023E10Rik 98915_at AI849082 RIKEN cDNA 1600023E10 gene44 0.00032 2.17 down Mm.219659 Hist2 93833_s_at X05862 histone gene complex 245 0.00033 3.35 down Mm.26587 Thra 99076_at U09504 thyroid hormone receptor alpha46 0.00033 4.69 up Mm.8180 Ly6a 93078_at X04653 lymphocyte antigen 6 complex, locus A47 0.00033 2.80 up Mm.22885 Mm.22885 95376_at AJ011107 Mus musculus mRNA for 3'UTR of Clc1 gene48 0.00038 1.62 down Mm.27278 Nme3 94982_f_at AI852470 expressed in non-metastatic cells 349 0.00038 1.61 up Mm.21619 2700012F11Rik 104069_at AI852737 RIKEN cDNA 2700012F11 gene50 0.00039 2.07 down Mm.27647 1110003E01Rik 160240_at AI852051 RIKEN cDNA 1110003E01 gene51 0.00039 4.40 up Mm.25309 Uck2-pending 94367_at AI850362 uridine-cytidine kinase 252 0.00039 1.93 down Mm.28797 Prtb 94454_at AF085348 proline rich protein expressed in brain53 0.00041 1.61 up Mm.21529 Rpl37a 93822_at X73331 ribosomal protein L37a54 0.00041 3.88 down Mm.1341 Egf 102774_at V00741 epidermal growth factor55 0.00042 2.59 down Mm.180546 2810011N17Rik 98065_at AI837679 RIKEN cDNA 2810011N17 gene56 0.00042 2.13 down Mm.28853 C79540 94473_at AW047951 expressed sequence C7954057 0.00043 2.08 down Mm.28258 1500016L11Rik 97841_at AI838663 RIKEN cDNA 1500016L11 gene58 0.00047 2.53 down Mm.213026 Bglap-rs1 102801_at L24430 bone gamma-carboxyglutamate protein, related sequence 159 0.00049 1.77 down Mm.3196 G2an 97516_at U92793 alpha glucosidase 2, alpha neutral subunit60 0.00052 2.52 down Mm.41573 Fmod 99152_at X94998 fibromodulin61 0.00053 2.98 down Mm.29333 2700067D09Rik 96817_at AI850550 RIKEN cDNA 2700067D09 gene62 0.00053 3.53 down Mm.6587 Prdx5 100622_at AF093857 peroxiredoxin 563 0.00053 1.75 down Mm.34775 Pdha1 98102_at M76727 pyruvate dehydrogenase E1 alpha 164 0.00053 1.98 down Mm.29386 1100001I23Rik 95120_at AI837621 RIKEN cDNA 1100001I23 gene65 0.00054 2.48 down Mm.4992 M32486 100477_at M32486 Mouse 19.5 mRNA66 0.00054 1.85 down Mm.7236 Ddost 101074_at D89063 dolichyl-di-phosphooligosaccharide-protein glycotransferase67 0.00054 1.93 down Mm.20903 Jcam1 103816_at U89915 junction cell adhesion molecule168 0.00055 2.58 down Mm.1055 Lmyc1 102235_at X13945 lung carcinoma myc related oncogene 169 0.00055 1.87 down Mm.30200 0610009I16Rik 96947_at AW046273 RIKEN cDNA 0610009I16 gene70 0.00057 2.05 down Mm.153790 C80126 103295_at AI854482 expressed sequence C8012671 0.00058 1.83 down Mm.8688 0610011B04Rik 101525_at AI848871 RIKEN cDNA 0610011B04 gene72 0.00058 2.02 down Mm.29856 9130022B02Rik 97398_at AI849831 RIKEN cDNA 9130022B02 gene73 0.00061 3.83 down Mm.30154 Fbp1 96918_at AI790931 fructose bisphosphatase 174 0.00064 1.79 down Mm.26772 2610207I16Rik 96096_f_at AI648018 RIKEN cDNA 2610207I16 gene75 0.00065 5.17 up Mm.195498 Slc25a17 97473_at AW124470 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein76 0.00067 2.47 down Mm.21622 4921531N22Rik 93842_at AI196645 RIKEN cDNA 4921531N22 gene77 0.00068 1.96 down Mm.23884 1300011P19Rik 93757_at AI843574 RIKEN cDNA 1300011P19 gene78 0.00068 3.11 down Mm.27155 Dgcr6 94956_at AF021031 DiGeorge syndrome chromosome region 679 0.00068 3.76 up Mm.10217 Syngr1 102221_at AJ002306 synaptogyrin 180 0.00069 2.63 down Mm.4290 1110020G17Rik 104208_at AI852011 RIKEN cDNA 1110020G17 gene81 0.00070 2.38 down Mm.20242 1810044O22Rik 103619_at AI850017 RIKEN cDNA 1810044O22 gene82 0.00071 2.69 up Mm.4851 Eng 100134_at X77952 endoglin83 0.00074 2.59 down Mm.24023 Mm.24023 160966_at AA145282 ESTs84 0.00074 2.12 down Mm.1776 Fth 94794_at X52561 ferritin heavy chain85 0.00075 2.32 down Mm.6519 C79050 100958_at AI647003 EST C7905086 0.00078 6.96 down Mm.182959 1700015E05Rik 94208_at AW045202 RIKEN cDNA 1700015E05 gene87 0.00080 1.98 up Mm.28239 Rnu22 97838_at AA684508 RNA, U22 small nucleolar88 0.00081 2.68 up Mm.7398 C81206 93621_at AA914350 expressed sequence C8120689 0.00084 1.82 down Mm.2804 2310016E22Rik 95620_at AW120882 RIKEN cDNA 2310016E22 gene90 0.00086 1.93 down Mm.29987 B230114J08Rik 96340_at AW124185 RIKEN cDNA B230114J08 genePage 1 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description91 0.00089 2.09 down Mm.143527 2500002L14Rik 101971_at AW061255 RIKEN cDNA 2500002L14 gene92 0.00092 1.75 up Mm.6419 BC004044 100949_at AI461767 hypothetical protein, BC00404493 0.00092 1.93 down Mm.22596 Tstap35b 102113_f_at AI324061 tissue specific transplantation antigen P35B94 0.00095 2.93 down Mm.606 Gata3 100924_at X55123 GATA binding protein 395 0.00096 2.91 down Mm.30028 Vps28 96847_at AI845393 vacuolar protein sorting 28 (yeast)96 0.00097 1.99 up Mm.1583 Ly6c 93077_s_at D86232 lymphocyte antigen 6 complex, locus C97 0.00099 10.79 up Mm.6433 SWAM2 161317_r_at AV088715 elafin-like protein II98 0.00103 2.45 down Mm.18643 Tctex3 103387_at AB011550 t-complex <strong>test</strong>is-expressed 399 0.00106 1.93 down Mm.18688 1110014C03Rik 93336_at AW121539 RIKEN cDNA 1110014C03 gene100 0.00108 4.37 down Mm.10753 Pnliprp1 92601_at AA674409 pancreatic lipase related protein 1101 0.00108 2.18 down Mm.88645 Tes 101551_s_at X78989 <strong>test</strong>is derived transcript102 0.00111 6.67 down Mm.182959 1700015E05Rik 94209_g_at AW045202 RIKEN cDNA 1700015E05 gene103 0.00112 2.41 down Mm.4582 Mer 92698_at U21301 c-mer proto-oncogene104 0.00113 2.19 down Mm.26833 AW047992 104015_at AW047992 expressed sequence AW047992105 0.00114 1.79 down Mm.30017 0610012F20Rik 96840_at AI851243 RIKEN cDNA 0610012F20 gene106 0.00115 2.68 down Mm.27943 Slc7a5 104221_at AB017189 solute carrier family 7 (cationic amino acid transporter, y+ system), member107 0.00115 1.99 up Mm.24794 2410001E19Rik 104758_at AA895984 RIKEN cDNA 2410001E19 gene108 0.00116 1.71 down Mm.14253 5730525G14Rik 102812_i_at AW210346 RIKEN cDNA 5730525G14 gene109 0.00117 2.20 down Mm.4808 Hivep1 92908_at L36829 human immunodeficiency virus type I enhancer binding protein 1110 0.00118 1.50 down Mm.2491 Hadhsc 95485_at D29639 L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain111 0.00119 2.71 down Mm.117294 Man1a 160580_at U04299 mannosidase 1, alpha112 0.00120 1.58 down Mm.25321 AI427847 96001_at AW122293 expressed sequence AI427847113 0.00123 1.93 up Mm.2322 Pim1 104533_at AA764261 proviral integration site 1114 0.00125 2.24 down Mm.22130 Rpn2 94076_i_at D31717 ribophorin II115 0.00125 4.27 up Mm.42093 Rbig1 102081_at AF060570 retinoblastoma inhibiting gene 1116 0.00128 3.02 down Mm.27154 Vnn1 104165_at AJ132098 vanin 1117 0.00129 2.06 up Mm.21764 Snrpg 93999_at AW060597 small nuclear ribonucleoprotein polypeptide G118 0.00132 2.90 up Mm.11827 1810030M08Rik 160590_r_at AI853323 RIKEN cDNA 1810030M08 gene119 0.00133 15.46 down Mm.6587 Prdx5 100332_s_at AF093853 peroxiredoxin 5120 0.00139 1.73 down Mm.29023 C76256 96771_at AI006228 expressed sequence C76256121 0.00142 3.14 down Mm.182227 4931406C07Rik 96089_at AI255972 RIKEN cDNA 4931406C07 gene122 0.00143 3.72 up Mm.4525 Cdh11 100006_at D21253 cadherin 11123 0.00143 3.66 up Mm.5038 Scg2 92981_at X68837 secretogranin II124 0.00144 1.61 down Mm.196239 4922501H04Rik 97447_at AI836718 RIKEN cDNA 4922501H04 gene125 0.00144 1.53 down Mm.30012 1110005P14Rik 96359_at AI836554 RIKEN cDNA 1110005P14 gene126 0.00145 3.31 up Mm.87857 Bcl2a1d 93869_s_at U23781 B-cell leukemia/lymphoma 2 related protein A1d127 0.00145 1.85 down Mm.24174 AI316495 94918_at AI839392 expressed sequence AI316495128 0.00147 4.24 down Mm.6772 C78582 93451_at AW047919 EST C78582129 0.00149 2.33 down Mm.135837 Mm.135837 160683_at AW049969 Mus musculus, Similar to hypothetical protein FLJ10618, clone IMAGE:3594130 0.00151 1.94 down Mm.22596 Tstap35b 94298_at X53619 tissue specific transplantation antigen P35B131 0.00151 1.62 down Mm.196630 AI046681 96240_at AI851309 expressed sequence AI046681132 0.00154 2.31 down Mm.27578 Maged1 96703_at AB029448 melanoma antigen, family D, 1133 0.00154 1.72 down Mm.35680 2310004K06Rik 160434_at AW122426 RIKEN cDNA 2310004K06 gene134 0.00154 2.90 down Mm.28357 Map1lc3 160288_at AI841311 microtubule-associated protein 1 light chain 3135 0.00155 1.92 down Mm.25848 Bckdha 96035_at L47335 branched chain ketoacid dehydrogenase E1, alpha polypeptide136 0.00156 1.88 down Mm.29455 1810045K07Rik 95146_at AI839280 RIKEN cDNA 1810045K07 gene137 0.00158 3.77 down Mm.28524 D6Wsu116e 98880_at AW124955 DNA segment, Chr 6, Wayne State University 116, expressed138 0.00160 2.32 down Mm.22681 Pon2 104378_at L48514 paraoxonase 2139 0.00161 2.65 down Mm.22682 Pip5k2c 160693_at AI849873 phosphatidylinositol-4-phosphate 5-kinase, type II, gamma140 0.00163 3.87 up Mm.17510 Msln 102953_at D86370 mesothelin141 0.00167 2.61 up Mm.35844 Gas5 98530_at AI849615 growth arrest specific 5142 0.00167 1.57 down Mm.29694 4633402N23Rik 97370_at AI552922 RIKEN cDNA 4633402N23 gene143 0.00175 7.00 up Mm.27498 Usp18 95024_at AW047653 ubiquitin specific protease 18144 0.00176 2.13 up Mm.18789 Sox4 101430_at AW124153 SRY-box containing gene 4145 0.00176 2.68 down Mm.34064 Stat5b 100422_i_at AJ237939 signal transducer and activator of transcription 5B146 0.00176 2.82 down Mm.8457 Cd59a 101516_at U60473 CD59a antigen147 0.00177 3.44 up Mm.1550 Stat4 102994_at U06923 signal transducer and activator of transcription 4148 0.00179 3.05 down Mm.2621 Aldh2 96057_at AI647493 aldehyde dehydrogenase 2, mitochondrial149 0.00179 3.18 down Mm.29192 Nars 95070_at AW125874 asparaginyl-tRNA synthetase150 0.00182 2.39 down Mm.44240 Mm.44240 100042_at AI837921 Mus musculus, Similar to hydroxyacyl glutathione hydrolase, clone MGC:669151 0.00186 1.57 down Mm.10406 3110001M13Rik 92574_at AI851046 RIKEN cDNA 3110001M13 gene152 0.00188 2.80 down Mm.5023 Pcp4 160899_at X17320 Purkinje cell protein 4153 0.00189 5.06 up Mm.88200 Cd72 101878_at J04170 CD72 antigen154 0.00190 1.97 down Mm.28704 Sec23b 98944_at AI848343 SEC23B (S. cerevisiae)155 0.00190 2.12 up Mm.34537 Cebpa 98447_at M62362 CCAAT/enhancer binding protein (C/EBP), alpha156 0.00192 2.50 up Mm.29581 Hey1 161451_r_at AV292193 hairy/enhancer-of-split related with YRPW motif 1157 0.00201 2.93 up Mm.27337 A030007L17Rik 94995_at AI854331 RIKEN cDNA A030007L17 gene158 0.00210 2.41 up Mm.4071 Lamr1 97750_at X06406 laminin receptor 1 (67kD, ribosomal protein SA)159 0.00210 1.66 down Mm.23836 Grs2-pending 94876_f_at AI849207 golgi reassembly stacking protein 2160 0.00211 1.83 up Mm.19127 Prdx4 93495_at U96746 peroxiredoxin 4161 0.00214 1.68 down Mm.24209 Mesdc2 95405_at AW045534 mesoderm development candiate 2162 0.00215 1.83 up Mm.218317 4930553M18Rik 104640_f_at AI464596 RIKEN cDNA 4930553M18 gene163 0.00216 1.84 down Mm.28357 Map1lc3 160287_at AI852557 microtubule-associated protein 1 light chain 3164 0.00218 2.71 down Mm.22479 Krt1-18 94270_at M22832 keratin complex 1, acidic, gene 18165 0.00220 2.30 down Mm.18800 Rab24 93347_at Z22819 RAB24, member RAS oncogene family166 0.00223 8.62 up Mm.24547 Aadac 95439_at AI047508 arylacetamide deacetylase (esterase)167 0.00225 4.08 up Mm.2970 Lgals3 95706_at X16834 lectin, galactose binding, soluble 3168 0.00229 2.87 up Mm.4132 Cish2 99475_at U88327 cytokine inducible SH2-containing protein 2169 0.00232 1.90 up Mm.1815 Ctps 103341_at U49350 cytidine 5'-triphosphate synthase170 0.00234 2.31 down Mm.3679 Ttc3 98555_at AB008516 tetratricopeptide repeat domain171 0.00239 1.91 down Mm.7504 Gss 101425_at U35456 glutathione synthetase172 0.00241 3.11 up Mm.2718 Eef1b2 96625_at AW123132 eukaryotic translation elongation factor 1 beta 2173 0.00244 1.53 down Mm.22635 AA415817 160163_at AI843518 expressed sequence AA415817174 0.00257 3.32 up Mm.46701 Tm4sf6 92555_at AF053454 transmembrane 4 superfamily member 6175 0.00258 1.52 down Mm.201455 AW122395 162426_f_at AV292472 expressed sequence AW122395176 0.00261 2.19 up Mm.193099 Fn1 92852_at M18194 fibronectin 1177 0.00263 1.71 down Mm.4025 Nfib 99440_at Y07686 nuclear factor I/B178 0.00263 1.97 down Mm.24670 9130410M22Rik 104739_at AW045650 RIKEN cDNA 9130410M22 gene179 0.00265 1.56 up Mm.380 Snk 92310_at M96163 serum-inducible kinase180 0.00265 2.07 up Mm.3090 Mm.3090 104513_at AA688938 ESTsPage 2 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description181 0.00266 2.52 down Mm.181862 1200015G06Rik 93590_at AI844370 RIKEN cDNA 1200015G06 gene182 0.00266 2.44 up Mm.3076 Scn8a 104505_at AI060993 sodium channel, voltage-gated, type VIII, alpha polypeptide183 0.00275 1.40 down Mm.3845 D6Ertd109e 96754_s_at AI844751 DNA segment, Chr 6, ERATO Doi 109, expressed184 0.00276 2.48 down Mm.21912 2810425J22Rik 104109_at AI853773 RIKEN cDNA 2810425J22 gene185 0.00279 2.37 up Mm.34346 Phlda3 98056_at AI846214 pleckstrin homology-like domain, family A, member 3186 0.00281 125.34 up Mm.6433 SWAM2 160914_at AA615849 elafin-like protein II187 0.00284 3.22 down Mm.18832 Hpgd 93351_at U44389 hydroxyprostaglandin dehydrogenase 15 (NAD)188 0.00285 2.57 down Mm.117294 Man1a 160579_at AI021125 mannosidase 1, alpha189 0.00289 5.77 up Mm.7122 2210021K23Rik 93480_at AI845559 RIKEN cDNA 2210021K23 gene190 0.00292 1.96 down Mm.1187 Hsd17b11 102370_at AA822174 hydroxysteroid 17-beta dehydrogenase 11191 0.00292 2.40 down Mm.21175 Ngrn-pending 103875_at AA967717 neugrin192 0.00295 2.10 up Mm.21936 Mm.21936 104112_at AI854033 ESTs, Highly similar to RAS-RELATED PROTEIN RAB-21 [M.musculus]193 0.00297 1.91 down Mm.20896 Invs 103811_at AJ010902 inversin194 0.00297 2.87 up Mm.24670 9130410M22Rik 162100_r_at AV360818 RIKEN cDNA 9130410M22 gene195 0.00298 2.06 up Mm.4502 Mcmd 160496_s_at AA929330 mini chromosome maintenance deficient (S. cerevisiae)196 0.00299 2.01 up Mm.4729 Dusp2 92758_at U09268 dual specificity phosphatase 2197 0.00303 2.23 down Mm.4048 Myd116 160463_at X51829 myeloid differentiation primary response gene 116198 0.00304 2.87 down Mm.26768 Pse-pending 104008_at AB019436 prostate specific ets transcription factor199 0.00307 3.68 up Mm.29105 Gtf3a 94559_at AW210248 general transcription factor III A200 0.00315 1.66 down Mm.27519 AA409659 104198_at AW211760 expressed sequence AA409659201 0.00319 1.69 down Mm.850 Srp14 101519_at M29264 signal recognition particle 14 kDa (homologous Alu RNA binding protein)202 0.00329 2.00 down Mm.12823 Tle1 102425_at U61362 transducin-like enhancer of split 1, homolog of Drosophila E(spl)203 0.00336 1.61 down Mm.116 H2-Oa 102991_s_at AF100956 histocompatibility 2, O region alpha locus204 0.00340 3.42 down Mm.38433 Wars 98605_at AI851163 tryptophanyl-tRNA synthetase205 0.00340 1.84 down Mm.88777 Fts 101892_f_at Z67963 fused toes206 0.00347 2.31 down Mm.3412 Rib1 98041_at X60103 ribonuclease 1, pancreatic207 0.00347 2.16 up Mm.139720 2610318G08Rik 98973_at AA982595 RIKEN cDNA 2610318G08 gene208 0.00349 2.03 up Mm.12743 Tsga2 160599_r_at AA089009 <strong>test</strong>is specific gene A2209 0.00353 2.10 down Mm.21637 AI461839 104070_at AW047728 expressed sequence AI461839210 0.00355 2.43 down Mm.1081 Atp6d 92603_at U13840 ATPase, H+ transporting, lysosomal (vacuolar proton pump), 42 kDa211 0.00355 2.10 down Mm.13774 AU022351 102784_at AI843949 expressed sequence AU022351212 0.00358 7.87 up Mm.4138 Crpd 99479_at U37438 crp-ductin213 0.00360 2.14 up Mm.29381 AU021460 95118_r_at AI131895 expressed sequence AU021460214 0.00367 4.62 up Mm.976 Fmo1 101991_at D16215 flavin containing monooxygenase 1215 0.00368 2.17 down Mm.27450 Akl3l-pending 160233_at AI854743 adenylate kinase 3 alpha like216 0.00368 3.78 up Mm.203962 Bat3 93912_at AW047616 HLA-B-associated transcript 3217 0.00372 1.83 down Mm.14253 5730525G14Rik 102813_f_at AW210346 RIKEN cDNA 5730525G14 gene218 0.00374 1.61 up Mm.34663 Nxt1 160429_at AW121314 NTF2-related export protein 1219 0.00377 1.82 down Mm.4210 Aldh3a2 99559_at U14390 aldehyde dehydrogenase family 3, subfamily A2220 0.00377 2.32 down Mm.24126 AI115388 104605_at AW047554 EST AI115388221 0.00379 3.02 up Mm.107339 Mm.107339 161573_at AV278013 ESTs, Weakly similar to T14031 sodium bicarbonate cotransporter, pancreat222 0.00384 1.94 down Mm.2830 2410016C14Rik 160285_at AI848996 RIKEN cDNA 2410016C14 gene223 0.00386 2.09 up Mm.86541 Ccr4 99535_at AW047630 carbon catabolite repression 4 homolog (S. cerevisiae)224 0.00388 2.42 down Mm.7244 Agr2 101075_f_at AB016592 anterior gradient 2 (Xenopus laevis)225 0.00389 3.53 up Mm.1891 AW909330 102978_at AI021175 expressed sequence AW909330226 0.00400 4.94 up Mm.4761 Cdc2a 100128_at M38724 cell division cycle 2 homolog A (S. pombe)227 0.00405 3.19 down Mm.14114 Ceacam1 102806_g_at M77196 CEA-related cell adhesion molecule 1228 0.00405 2.40 up Mm.13913 Psmb8 102791_at U22033 proteosome (prosome, macropain) subunit, beta type 8 (large multifunctiona229 0.00412 2.04 down Mm.28659 Pes1 160788_at AI846045 pescadillo homolog 1, containing BRCT domain (zebrafish)230 0.00415 1.76 down Mm.28163 1810004P07Rik 97811_at AI844507 RIKEN cDNA 1810004P07 gene231 0.00421 2.34 down Mm.22168 Sas 104147_at AW122052 sialic acid synthase232 0.00425 3.46 up Mm.3189 Pirb 98003_at AF038149 paired-Ig-like receptor B233 0.00432 1.88 down Mm.141187 Tgoln2 99143_at AA614914 trans-golgi network protein 2234 0.00434 3.55 up Mm.3233 Irf7 104669_at U73037 interferon regulatory factor 7235 0.00442 2.10 up Mm.2647 Pfn1 96070_at X14425 profilin 1236 0.00450 2.39 down Mm.28665 AI327354 160789_at AW120525 expressed sequence AI327354237 0.00460 1.62 up Mm.4973 Trim25 100475_at D63902 tripartite motif protein 25238 0.00462 2.22 down Mm.7044 Acas2 160921_at AW125884 acetyl-Coenzyme A synthetase 2239 0.00463 2.04 down Mm.2752 Prlr 95030_at D10214 prolactin receptor240 0.00463 3.66 up Mm.24851 Mm.24851 95940_f_at AW047237 ESTs241 0.00464 2.06 down Mm.1603 Rbbp7 93081_at U35142 retinoblastoma binding protein 7242 0.00466 1.99 down Mm.200582 AI843547 96176_at AI847916 expressed sequence AI843547243 0.00472 1.81 down Mm.34365 Dusp12 98431_at AW049275 dual specificity phosphatase 12244 0.00475 2.85 down Mm.30061 Azgp1 96867_at D44593 alpha-2-glycoprotein 1, zinc245 0.00479 3.00 down Mm.14114 Ceacam1 102805_at M77196 CEA-related cell adhesion molecule 1246 0.00482 2.37 down Mm.2433 Man2a1 104628_at X61172 mannosidase 2, alpha 1247 0.00484 3.67 up Mm.3440 Adss1 98435_at M74495 adenylosuccinate synthetase 1, muscle248 0.00486 1.92 up Mm.13194 Fscn1 92838_at L33726 fascin homolog 1 (actin bundling protein, Strongylocentrotus purpuratus)249 0.00486 1.86 down Mm.110 Idb3 92614_at M60523 inhibitor of DNA binding 3250 0.00490 5.23 down Mm.27646 Papss2 96713_at AF052453 3'-phosphoadenosine 5'-phosphosulfate synthase 2251 0.00493 2.33 up Mm.4915 Gabra6 92939_at X51986 gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 6252 0.00498 3.12 up Mm.2786 Proc 95585_at AF034569 protein C253 0.00500 2.63 up Mm.36416 Fzd2 93681_at AW123618 frizzled homolog 2 (Drosophila)254 0.00501 2.63 up Mm.35844 Gas5 98531_g_at AI849615 growth arrest specific 5255 0.00503 2.62 down Mm.2779 Gpld1 95566_at AF050666 glycosylphosphatidylinositol specific phospholipase D1256 0.00506 2.61 down Mm.27339 5430411C10Rik 96656_at AI644179 RIKEN cDNA 5430411C10 gene257 0.00508 3.42 down Mm.42255 Atp2a2 99570_s_at AF029982 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2258 0.00514 1.77 down Mm.203928 Stx3 100499_at D29797 syntaxin 3259 0.00515 4.45 down Mm.3537 Ren1 98480_s_at M32352 renin 1 structural260 0.00515 2.28 up Mm.215960 Mm.215960 100344_at AI464141 Mus musculus, similar to quinone reductase-like protein, clone IMAGE:49724261 0.00519 2.89 down Mm.21356 1010001C05Rik 93786_i_at AI837302 RIKEN cDNA 1010001C05 gene262 0.00520 1.93 up Mm.181894 2900092E17Rik 95759_at AW123746 RIKEN cDNA 2900092E17 gene263 0.00524 1.36 down Mm.28643 Vamp2 98926_at AI838601 vesicle-associated membrane protein 2264 0.00528 2.16 down Mm.29959 1600029D21Rik 97413_at AI121305 RIKEN cDNA 1600029D21 gene265 0.00529 1.92 up Mm.26237 Cry1 94420_f_at AB000777 cryptochrome 1 (photolyase-like)266 0.00532 1.35 down Mm.29141 0710008N11Rik 95053_s_at AA674669 RIKEN cDNA 0710008N11 gene267 0.00532 3.12 up Mm.3333 Apobec1 98398_s_at U22262 apolipoprotein B editing complex 1268 0.00532 2.98 up Mm.18957 Mm.18957 103424_at AI844839 ESTs, Weakly similar to FOR4 MOUSE FORMIN 4 [M.musculus]269 0.00535 3.97 up Mm.142275 Cdk5r 102664_at U89527 cyclin-dependent kinase 5, regulatory subunit (p35)270 0.00539 2.83 down Mm.29144 D15Wsu59e 95054_at AI849620 DNA segment, Chr 15, Wayne State University 59, expressedPage 3 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description271 0.00544 3.82 up Mm.6222 Aoah 99838_at AF018172 acyloxyacyl hydrolase272 0.00544 1.65 down Mm.12192 D11Ertd204e 160592_at AI874754 DNA segment, Chr 11, ERATO Doi 204, expressed273 0.00546 2.15 down Mm.201525 AI854539 100982_at AI854539 expressed sequence AI854539274 0.00549 1.63 down Mm.1779 Scp2 95787_s_at X87685 sterol carrier protein 2, liver275 0.00551 2.39 up Mm.29766 Gmfg 97384_at AA791012 glia maturation factor, gamma276 0.00552 2.37 up Mm.21156 C77440 162061_f_at AV274270 expressed sequence C77440277 0.00553 1.80 up Mm.1541 Snta1 102890_at U00677 syntrophin, acidic 1278 0.00554 1.35 up Mm.12144 Mrpl23 92646_at U84903 mitochondrial ribosomal protein L23279 0.00555 1.98 down Mm.212497 9430029A22Rik 103754_at AI847826 RIKEN cDNA 9430029A22 gene280 0.00557 2.47 up Mm.3303 Fcgrt 97533_at L17022 Fc receptor, IgG, alpha chain transporter281 0.00559 2.03 down Mm.17403 1200014I03Rik 93270_at AI839918 RIKEN cDNA 1200014I03 gene282 0.00562 3.01 up Mm.36564 Mm.36564 97192_at AA517444 ESTs283 0.00564 2.49 down Mm.844 AI451877 93693_at AI835373 expressed sequence AI451877284 0.00565 1.71 down Mm.116 H2-Oa 103371_at AF100956 histocompatibility 2, O region alpha locus285 0.00574 1.69 up Mm.18789 Sox4 160109_at X70298 SRY-box containing gene 4286 0.00575 1.70 down Mm.28327 2510049I19Rik 97865_g_at AW258842 RIKEN cDNA 2510049I19 gene287 0.00576 3.07 up Mm.2580 Sdc1 161370_f_at AV239731 syndecan 1288 0.00579 1.48 down Mm.1519 Abcd3 93045_at L28836 ATP-binding cassette, sub-family D (ALD), member 3289 0.00581 2.04 down Mm.31 Bcl7b 97490_at AJ011145 B-cell CLL/lymphoma 7B290 0.00584 1.84 down Mm.17009 Rip1 93255_at X80937 Ral-interacting protein 1291 0.00584 2.14 up Mm.21289 Rps12 102126_at X15962 ribosomal protein S12292 0.00585 2.20 down Mm.12969 Dpm1 92828_at AB004789 dolichol-phosphate (beta-D) mannosyltransferase 1293 0.00591 3.83 up Mm.13020 Rpl13a 92834_at X51528 ribosomal protein L13a294 0.00591 1.51 up Mm.2675 Pdgfa 94932_at M29464 platelet derived growth factor, alpha295 0.00592 1.53 down Mm.784 Nbr1 101484_at U73039 next to the Brca1296 0.00600 2.30 up Mm.784 Nbr1 162423_f_at AV291681 next to the Brca1297 0.00610 3.13 up Mm.46382 2310061N23Rik 92718_at AI158810 RIKEN cDNA 2310061N23 gene298 0.00612 1.45 down Mm.24272 6030432N09Rik 95413_at AI851332 RIKEN cDNA 6030432N09 gene299 0.00614 2.34 down 95340_at M93310300 0.00617 2.10 down Mm.27357 AU015843 96661_at AA734806 expressed sequence AU015843301 0.00621 2.62 down Mm.38433 Wars 98606_s_at X69656 tryptophanyl-tRNA synthetase302 0.00626 1.94 down Mm.7198 Mkrn1 101070_at AW125438 makorin, ring finger protein, 1303 0.00631 1.77 down Mm.2658 Mm.2658 103999_at AI852034 ESTs304 0.00634 2.28 up Mm.3158 Rplp1 100694_at U29402 ribosomal protein, large, P1305 0.00635 3.14 down Mm.28261 Ncoa4 97843_at AI834866 nuclear receptor coactivator 4306 0.00635 2.52 down Mm.218381 ep 93901_at U78315 pale ear307 0.00637 3.81 up Mm.10764 Bard1 94128_at AF057157 BRCA1 associated RING domain 1308 0.00642 2.92 up Mm.6238 Sox11 101631_at AF009414 SRY-box containing gene 11309 0.00643 1.54 up Mm.27832 Ralb 160756_at AI847236 v-ral simian leukemia viral oncogene homolog B (ras related)310 0.00644 3.32 up Mm.28973 Icam1 96752_at M90551 intercellular adhesion molecule311 0.00646 2.48 up Mm.3277 Col9a2 98027_at Z22923 procollagen, type IX, alpha 2312 0.00648 2.41 up Mm.181935 Lip1 102123_at Z31689 lysosomal acid lipase 1313 0.00653 3.08 down Mm.2644 AI415009 94428_at AI842668 expressed sequence AI415009314 0.00654 1.87 down Mm.38306 Maea 160450_at AW121555 macrophage erythroblast attacher315 0.00659 1.89 down Mm.21203 AI227013 93772_i_at AI835041 expressed sequence AI227013316 0.00662 1.53 down Mm.28173 Mm.28173 96138_at AA682129 ESTs, Moderately similar to JC5224 methionine--tRNA ligase [H.sapiens]317 0.00662 1.53 down Mm.196577 D17Wsu92e 95002_at AI838731 DNA segment, Chr 17, Wayne State University 92, expressed318 0.00666 1.76 up Mm.22669 D11Bwg0554e 162415_f_at AV321392 DNA segment, Chr 11, Brigham & Women's Genetics 0554 expressed319 0.00668 1.67 down Mm.4465 Fbxw2 100056_at X54352 f-box and WD-40 domain protein 2320 0.00669 3.51 up Mm.18876 AU040575 103418_at AW122092 expressed sequence AU040575321 0.00670 3.31 up Mm.16660 P4hb 93108_at J05185 prolyl 4-hydroxylase, beta polypeptide322 0.00671 1.76 up Mm.124 Tmpo 98982_at AW046443 thymopoietin323 0.00672 1.59 down Mm.29690 4930415K17Rik 95701_at AW124069 RIKEN cDNA 4930415K17 gene324 0.00672 6.34 up Mm.7526 Cugbp1 104073_at AI847630 CUG triplet repeat, RNA binding protein 1325 0.00673 2.00 down Mm.197522 Gnas 93271_s_at AF107848 GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus326 0.00679 1.89 up Mm.142380 Rpl27a 101573_f_at AB020237 ribosomal protein L27a327 0.00679 1.78 down Mm.203911 AA407887 94247_at AA600542 expressed sequence AA407887328 0.00686 4.12 up Mm.4950 Isg15 98822_at X56602 interferon-stimulated protein (15 kDa)329 0.00692 3.08 down Mm.754 Ace 161224_f_at AV258262 angiotensin converting enzyme330 0.00696 1.98 up Mm.22456 2610017G09Rik 104326_at AI838951 RIKEN cDNA 2610017G09 gene331 0.00698 2.43 down Mm.153420 Mm.153420 104699_at AI847699 Mus musculus, Similar to phosphatidylinositol 3-kinase, clone MGC:30377 IM332 0.00699 1.37 down Mm.35738 Catns 98152_at AW122407 catenin src333 0.00709 1.71 up Mm.38976 AA409661 99084_s_at AA718792 expressed sequence AA409661334 0.00720 3.01 down Mm.21593 2610028P08Rik 103450_at AA061133 RIKEN cDNA 2610028P08 gene335 0.00728 2.33 down Mm.34064 Stat5b 100423_f_at AJ237939 signal transducer and activator of transcription 5B336 0.00730 2.09 up Mm.20461 Ggh 93575_at AF051102 gamma-glutamyl hydrolase337 0.00730 1.57 up Mm.3860 Ryk 160453_at L21707 receptor-like tyrosine kinase338 0.00733 1.80 down Mm.2411 G3bp2-pending 101106_at AI853331 Ras-GTPase-activating protein (GAP) SH3-domain binding protein 2339 0.00735 2.20 down Mm.28670 2610016K11Rik 98931_at AW123589 RIKEN cDNA 2610016K11 gene340 0.00736 1.71 down Mm.141443 Ldh1 96072_at M17516 lactate dehydrogenase 1, A chain341 0.00738 1.52 down Mm.29699 Ap1b1 95704_at Y07919 adaptor protein complex AP-1, beta 1 subunit342 0.00738 2.04 down Mm.30234 Mm.30234 160397_at AI790328 Mus musculus, Similar to IK cytokine, down-regulator of HLA II, clone MGC:2343 0.00741 2.48 down Mm.22045 Cypf13 104129_at AI462001 cytochrome P450 CYP4F13344 0.00746 2.11 down Mm.2942 Asns 95133_at U38940 asparagine synthetase345 0.00748 2.28 up Mm.29043 Wbp3 96512_at U92453 WW domain binding protein 3346 0.00751 2.96 up Mm.24347 Mm.24347 95904_at AI835760 ESTs, Weakly similar to T31613 hypothetical protein Y50E8A.i - Caenorhabd347 0.00758 2.10 down Mm.190436 2010012F05Rik 103555_at AI843520 RIKEN cDNA 2010012F05 gene348 0.00763 4.39 up Mm.2055 Mmp12 95339_r_at M82831 matrix metalloproteinase 12349 0.00763 1.53 up Mm.13773 2310009E04Rik 102783_at AI131744 RIKEN cDNA 2310009E04 gene350 0.00765 1.94 down Mm.443 Mthfd2 100046_at J04627 methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetra351 0.00765 2.03 down Mm.69521 Mm.69521 161636_r_at AV009532 ESTs, Highly similar to A57286 probable serine/threonine protein kinase [M.m352 0.00771 1.92 down Mm.754 Ace 160927_at J04946 angiotensin converting enzyme353 0.00773 2.08 down Mm.8534 Egfr 101842_g_at AW049716 epidermal growth factor receptor354 0.00775 1.55 up Mm.205476 Mm.205476 99168_at AW047128 ESTs, Weakly similar to T14G10.7.p [Caenorhabditis elegans] [C.elegans]355 0.00777 1.53 down Mm.4025 Nfib 160859_s_at Y07685 nuclear factor I/B356 0.00782 1.71 down Mm.28512 Mm.28512 96191_at AI852124 Mus musculus, clone IMAGE:5037434, mRNA, partial cds357 0.00782 1.66 down Mm.28349 Mm.28349 97874_at AI853863 Mus musculus, Similar to MIPP65 protein, clone MGC:18783 IMAGE:418823358 0.00783 2.24 down Mm.299 Temt 97402_at M88694 thioether S-methyltransferase359 0.00783 2.66 up Mm.2296 Pdi2 103526_at D16580 peptidyl arginine deiminase, type II360 0.00785 1.95 down Mm.145488 AU018965 93564_at AW122542 expressed sequence AU018965Page 4 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description361 0.00791 1.76 down Mm.24397 4933436C10Rik 160188_at AI854103 RIKEN cDNA 4933436C10 gene362 0.00795 1.71 up Mm.372 Rps26 98564_f_at U67770 ribosomal protein S26363 0.00798 2.91 up Mm.30502 2210039B01Rik 98524_f_at AI848479 RIKEN cDNA 2210039B01 gene364 0.00801 1.87 down Mm.2283 Nucb 94839_at M96823 nucleobindin365 0.00801 1.54 down Mm.98 Psmb6 101992_at U13393 proteasome (prosome, macropain) subunit, beta type 6366 0.00803 3.59 up Mm.1347 Hlx 102657_at X58250 H2.0-like homeo box gene367 0.00806 1.72 down Mm.22473 Rabac1 94269_at L40934 Rab acceptor 1 (prenylated)368 0.00807 3.22 down Mm.20934 Hipk2 103833_at AF077659 homeodomain interacting protein kinase 2369 0.00808 2.02 down Mm.34525 4930406E12Rik 98445_at AW125311 RIKEN cDNA 4930406E12 gene370 0.00809 1.40 down Mm.1024 Mm.1024 94106_at AI853048 ESTs371 0.00810 2.62 down Mm.182434 1700066C05Rik 102348_at AI551087 RIKEN cDNA 1700066C05 gene372 0.00813 1.90 down Mm.10727 Atp6b2 92598_at AI843029 ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa373 0.00818 1.49 up Mm.2845 Tcfubf 97901_at X60831 transcription factor UBF374 0.00819 4.06 up Mm.101230 Mm.101230 99425_at X07888 Mus musculus, Similar to 3-hydroxy-3-methylglutaryl-Coenzyme A reductase375 0.00823 6.34 up Mm.219138 Mm.219138 95352_at C75967 ESTs376 0.00823 1.67 up Mm.2443 Bak1 104710_at Y13231 BCL2-antagonist/killer 1377 0.00826 2.52 up Mm.25029 C79329 95981_at C79329 expressed sequence C79329378 0.00829 3.74 down Mm.7114 2210008A03Rik 101384_at AI852933 RIKEN cDNA 2210008A03 gene379 0.00831 2.39 down Mm.1779 Scp2 93278_at M91458 sterol carrier protein 2, liver380 0.00833 3.72 up Mm.31041 Gstm6 104637_at AI326397 glutathione S-transferase, mu 6381 0.00836 1.84 down Mm.21771 Cul1 94002_at AI849838 cullin 1382 0.00840 5.04 up Mm.38260 Mm.38260 92319_i_at AA675031 ESTs383 0.00846 2.45 up Mm.21146 Gata6 104698_at U51335 GATA binding protein 6384 0.00846 1.44 down Mm.41853 Dnase2a 99184_at AW120896 deoxyribonuclease II alpha385 0.00856 1.43 down Mm.34789 1200014P03Rik 98461_at AI987835 RIKEN cDNA 1200014P03 gene386 0.00858 1.97 down Mm.21069 0610007A03Rik 93743_at AI838388 RIKEN cDNA 0610007A03 gene387 0.00860 2.56 up Mm.1585 Tm7sf1 103017_at AI060729 transmembrane 7 superfamily member 1388 0.00868 1.89 down Mm.201455 AW122395 160795_at AW123662 expressed sequence AW122395389 0.00879 3.20 up Mm.2786 Proc 161656_r_at AV103587 protein C390 0.00882 2.12 down Mm.21830 Ril-pending 104094_at Y08361 reversion induced LIM gene391 0.00885 1.84 down Mm.18516 H3f3b 100708_at X13605 H3 histone, family 3B392 0.00886 2.18 up Mm.139720 2610318G08Rik 102385_at AA980618 RIKEN cDNA 2610318G08 gene393 0.00886 2.28 down Mm.29812 Sep15-pending 96249_at AW122105 15-kDa selenoprotein394 0.00890 1.75 down Mm.45465 4921506I22Rik 100547_at AI836977 RIKEN cDNA 4921506I22 gene395 0.00893 1.81 down Mm.171115 Mm.171115 160403_at AW122690 ESTs396 0.00894 3.70 up Mm.3076 Scn8a 104504_at U26707 sodium channel, voltage-gated, type VIII, alpha polypeptide397 0.00898 2.84 up Mm.132399 Galnt6 96998_at AJ133523 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltra398 0.00904 1.43 down Mm.34750 Nudt9 98099_at AW045760 nudix (nucleoside diphosphate linked moiety X)-type motif 9399 0.00907 4.90 up Mm.7226 Tcf2 162159_i_at AV026659 transcription factor 2400 0.00911 2.10 up Mm.1260 Nme1 161161_r_at AV216468 expressed in non-metastatic cells 1, protein (NM23A) (nucleoside diphospha401 0.00913 2.01 up Mm.68157 Mm.68157 98800_at U25739 ESTs, Weakly similar to JC7182 Na+-dependent vitamin C [H.sapiens]402 0.00913 3.70 up Mm.27503 5730408K05Rik 104195_at AA939440 RIKEN cDNA 5730408K05 gene403 0.00918 2.57 up Mm.7622 Akap2 101435_at AF033275 A kinase anchor protein 2404 0.00923 5.31 up Mm.200446 AW540062 162183_at AV013237 expressed sequence AW540062405 0.00925 3.93 up Mm.4032 Resp18 99442_at L34214 regulated endocrine-specific protein 18406 0.00926 1.83 down Mm.2462 Psmc2 95448_at AI839371 proteasome (prosome, macropain) 26S subunit, ATPase 2407 0.00928 2.03 up Mm.41923 Rpl18 160476_f_at AI839717 ribosomal protein L18408 0.00930 1.23 down Mm.28466 Slc25a11 160295_at AW049350 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member409 0.00934 1.58 down Mm.35098 0610011F06Rik 98124_at AI875453 RIKEN cDNA 0610011F06 gene410 0.00937 2.11 down Mm.29910 Rps6ka1 97405_at M28489 ribosomal protein S6 kinase polypeptide 1411 0.00941 2.44 up Mm.26859 Gjb5 104016_at M91236 gap junction membrane channel protein beta 5412 0.00942 2.05 down Mm.6988 Alad 101044_at X13752 aminolevulinate, delta-, dehydratase413 0.00943 3.07 up Mm.189129 Mm.189129 161693_r_at AV230283 EST414 0.00943 2.35 down Mm.595 Bmp7 93243_at X56906 bone morphogenetic protein 7415 0.00946 2.64 up Mm.665 Psmc5 161921_f_at AV139898 protease (prosome, macropain) 26S subunit, ATPase 5416 0.00949 1.62 down Mm.30085 Akr1a4 96888_at AI839814 aldo-keto reductase family 1, member A4 (aldehyde reductase)417 0.00953 1.76 down Mm.73251 2210402G22Rik 97484_at AI852704 RIKEN cDNA 2210402G22 gene418 0.00953 7.96 up Mm.42124 Slfn2 92471_i_at AF099973 schlafen 2419 0.00955 1.78 up Mm.1972 Rac2 103579_at X53247 RAS-related C3 botulinum substrate 2420 0.00962 3.22 up Mm.2724 Folr2 104172_at M64817 folate receptor 2 (fetal)421 0.00963 1.27 up Mm.22193 2310004N11Rik 104152_at AA960466 RIKEN cDNA 2310004N11 gene422 0.00968 1.98 down Mm.14101 H1f4 94288_at J03482 H1 histone family, member 4423 0.00971 2.10 down 96755_at AA638002424 0.00973 1.57 down Mm.5248 Tsnax 100534_at AI183109 translin-associated factor X425 0.00977 1.65 up Mm.2814 Mpp1 97803_at U38196 membrane protein, palmitoylated (55 kDa)426 0.00980 1.73 down Mm.28794 1810046J19Rik 94453_at AI852571 RIKEN cDNA 1810046J19 gene427 0.00982 1.74 up Mm.29646 0610010E05Rik 162081_f_at AV312736 RIKEN cDNA 0610010E05 gene428 0.00988 3.09 down Mm.212992 Mm.212992 161900_f_at AV373835 ESTs, Moderately similar to B3AR MOUSE BETA-3 ADRENERGIC RECEPT429 0.00991 1.88 up Mm.30205 Scya19 96950_at AW120505 small inducible cytokine A19430 0.00993 1.54 down Mm.208 1110060D06Rik 103260_at AI838553 RIKEN cDNA 1110060D06 gene431 0.00993 3.32 up Mm.42157 Hivep2 92484_at Y15907 human immunodeficiency virus type I enhancer binding protein 2432 0.00995 2.41 up Mm.4974 Ncam1 161750_f_at AV324706 neural cell adhesion molecule 1433 0.01008 3.41 up Mm.154045 Tacstd2 160651_at AI563854 tumor-associated calcium signal transducer 2434 0.01009 2.73 down Mm.9590 Nakap95-pending 101947_at AB028921 neighbor of A-kinase anchoring protein 95435 0.01011 2.10 up Mm.16533 Rpo2-1 103055_r_at M12130 RNA polymerase II 1436 0.01014 1.65 down Mm.1304 Slc11a2 102642_at L33415 solute carrier family 11 (proton-coupled divalent metal ion transporters), mem437 0.01020 1.92 down Mm.15868 Vdp-pending 103018_at AF096868 vesicle docking protein, 115 kDa438 0.01021 4.63 up Mm.15793 Tgtp 102906_at L38444 T-cell specific GTPase439 0.01023 2.64 up Mm.22712 1700017B05Rik 104389_at AW049360 RIKEN cDNA 1700017B05 gene440 0.01030 1.90 down Mm.21580 0610006A03Rik 93835_at AI843222 RIKEN cDNA 0610006A03 gene441 0.01033 1.67 up Mm.28983 1110007M04Rik 96756_at AA693236 RIKEN cDNA 1110007M04 gene442 0.01046 2.71 down Mm.104540 Napa 98887_at AW125607 N-ethylmaleimide sensitive fusion protein attachment protein alpha443 0.01046 1.50 down Mm.177990 1700008C22Rik 160123_at AI835524 RIKEN cDNA 1700008C22 gene444 0.01046 1.56 down Mm.178947 Becn1 160380_at AI846699 beclin 1 (coiled-coil, myosin-like BCL2-interacting protein)445 0.01046 2.25 up Mm.1196 AW536703 102090_f_at AI841710 expressed sequence AW536703446 0.01054 2.82 down Mm.3982 Gas6 99067_at X59846 growth arrest specific 6447 0.01056 1.59 down Mm.148348 1500005G05Rik 103922_f_at AI839690 RIKEN cDNA 1500005G05 gene448 0.01058 1.86 down Mm.22522 Mbd1 104340_at AF072240 methyl-CpG binding domain protein 1449 0.01059 2.73 up Mm.20246 2410004D18Rik 160122_at AW061161 RIKEN cDNA 2410004D18 gene450 0.01063 2.61 up Mm.136604 Nfil3 101805_f_at U89411 nuclear factor, interleukin 3, regulatedPage 5 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description451 0.01076 3.20 up Mm.2095 Zfp64 103841_at U49046 zinc finger protein 64452 0.01092 2.34 up Mm.30375 Klk5 161637_f_at AV053185 kallikrein 5453 0.01092 1.45 down Mm.200125 Sqstm1 101995_at U40930 sequestosome 1454 0.01096 2.32 up Mm.2900 Fmo3 104421_at U87147 flavin containing monooxygenase 3455 0.01101 3.19 up Mm.172 Lox 161177_f_at AV232133 lysyl oxidase456 0.01105 1.77 up Mm.38261 Ubce8 97171_f_at AI060627 ubiquitin-conjugating enzyme 8457 0.01111 1.97 down Mm.29161 Slc16a7 95060_at AF058054 solute carrier family 16 (monocarboxylic acid transporters), member 7458 0.01111 2.64 up Mm.29055 Cbx1 96775_at X56690 chromobox homolog 1 (Drosophila HP1 beta)459 0.01112 1.42 down Mm.4352 Col15a1 99638_at D17546 procollagen, type XV460 0.01118 2.43 up Mm.968 Nr1h2 101981_at U09419 nuclear receptor subfamily 1, group H, member 2461 0.01119 3.31 up Mm.1181 Retn 102366_at AA718169 resistin462 0.01120 2.75 up Mm.214642 Mm.214642 100769_at AU045946 Mus musculus zinc finger protein 352 mRNA, complete cds463 0.01120 2.26 down Mm.22543 AI429776 104348_at AI835152 expressed sequence AI429776464 0.01126 2.92 up Mm.11738 Stk6 92639_at U80932 serine/threonine kinase 6465 0.01126 1.80 down Mm.182913 Csnk1d 97262_at AW050305 casein kinase 1, delta466 0.01127 4.44 down Mm.25351 AV067083 94370_at AA615075 expressed sequence AV067083467 0.01132 3.96 up 95366_at L35599468 0.01134 1.88 down Mm.13694 Oat 92848_at X64837 ornithine aminotransferase469 0.01138 2.07 up Mm.30212 C76483 96954_at AW122567 EST C76483470 0.01144 1.74 down Mm.25709 Ing1 94396_at AA647507 inhibitor of growth family, member 1471 0.01146 2.18 up Mm.3146 Tcf20 97090_at U20282 transcription factor 20472 0.01147 3.66 up Mm.56895 D17H6S56E-3 93197_at AF109905 DNA segment, Chr 17, human D6S56E 3473 0.01148 1.83 down Mm.29812 Sep15-pending 160360_at AI838205 15-kDa selenoprotein474 0.01150 2.32 up Mm.6224 Stx1bl-pending 101643_at D45207 syntaxin 1 b-like475 0.01153 1.74 down Mm.7418 Ppp2cb 101101_at Z67746 protein phosphatase 2a, catalytic subunit, beta isoform476 0.01153 1.82 down Mm.9392 Golga3 93951_at AB029537 golgi autoantigen, golgin subfamily a, 3477 0.01160 1.55 up Mm.195926 D8Ertd319e 103924_at AW048884 DNA segment, Chr 8, ERATO Doi 319, expressed478 0.01163 1.77 down Mm.3868 Yy1 98767_at AI842603 YY1 transcription factor479 0.01164 1.61 down Mm.23693 2010320M17Rik 94862_i_at AI850000 RIKEN cDNA 2010320M17 gene480 0.01170 9.85 up Mm.80559 Mm.80559 161107_r_at AA529901 ESTs, Weakly similar to W01A11.2.p [Caenorhabditis elegans] [C.elegans]481 0.01171 1.63 down Mm.22333 Rpn1 94237_at AI846708 ribophorin I482 0.01172 2.64 down 103083_at U69543483 0.01174 1.63 down Mm.154581 Aco2 96870_at AI836740 aconitase 2, mitochondrial484 0.01176 2.01 up Mm.154355 2700066J21Rik 104470_at AI957346 RIKEN cDNA 2700066J21 gene485 0.01178 1.56 up Mm.12858 Eif4a1 92816_r_at X03039 eukaryotic translation initiation factor 4A1486 0.01180 1.52 down Mm.2412 Ppib 94915_at X58990 peptidylprolyl isomerase B487 0.01181 1.65 down Mm.18520 5730494M16Rik 103364_f_at AW045256 RIKEN cDNA 5730494M16 gene488 0.01182 2.09 down Mm.25632 9030624B09Rik 94983_at AI851614 RIKEN cDNA 9030624B09 gene489 0.01182 2.01 up Mm.22592 Ccnb2 94294_at X66032 cyclin B2490 0.01183 1.77 down Mm.6417 Cd24a 100600_at M58661 CD24a antigen491 0.01189 2.74 up Mm.18064 G6pc 103333_at U00445 glucose-6-phosphatase, catalytic492 0.01191 1.43 up Mm.29383 Mm.29383 96822_at AA734428 ESTs, Highly similar to E2BE RAT TRANSLATION INITIATION FACTOR EIF493 0.01193 3.54 up Mm.202045 AI173996 95283_at AI173996 expressed sequence AI173996494 0.01197 2.01 down Mm.19981 Dagk1 103596_at AF085219 diacylglycerol kinase, alpha (80 kDa)495 0.01207 4.36 up Mm.1401 Cmkar4 102794_at Z80112 chemokine (C-X-C) receptor 4496 0.01207 2.32 up Mm.219665 Mm.219665 161480_i_at AV055186 Mus musculus, Similar to KIAA1089 protein, clone MGC:30464 IMAGE:3992497 0.01211 1.68 down Mm.6250 Prom 93390_g_at AF039663 prominin498 0.01213 2.14 down Mm.4270 Atbf1 92521_at D26046 AT motif binding factor 1499 0.01216 2.36 down Mm.39038 Mm.39038 99033_at AI837130 Mus musculus, Similar to inositol 1,3,4-triphosphate 5/6 kinase, clone IMAGE500 0.01216 2.21 up Mm.193432 ORF18 161667_r_at AV139526 open reading frame 18501 0.01225 2.12 down Mm.709 Grp58 101060_at M73329 glucose regulated protein, 58 kDa502 0.01227 1.83 down Mm.21507 1810020N21Rik 93819_at AI847269 RIKEN cDNA 1810020N21 gene503 0.01228 1.90 down Mm.193395 6330580J24Rik 160346_at AI841825 RIKEN cDNA 6330580J24 gene504 0.01235 1.41 down Mm.340 Hmgb3 98038_at AF022465 high mobility group box 3505 0.01239 2.43 up Mm.25248 AA960558 162252_f_at AV335799 expressed sequence AA960558506 0.01242 1.46 down Mm.157042 AA408125 101943_at AA960259 expressed sequence AA408125507 0.01246 2.71 up Mm.21880 Prss25 104102_at AW047978 protease, serine, 25508 0.01250 1.72 down Mm.20169 2310005K03Rik 103225_at AW018420 RIKEN cDNA 2310005K03 gene509 0.01257 2.35 up Mm.2241 Arhgdib 94258_at L07918 rho, GDP dissociation inhibitor (GDI) beta510 0.01259 1.46 down Mm.23030 AI447437 92243_at AA117417 expressed sequence AI447437511 0.01261 1.68 up Mm.6161 Pcyt1a 161074_at AW107428 phosphate cytidylyltransferase 1, choline, alpha isoform512 0.01262 2.66 up Mm.4411 Gcnt1 92655_at U19265 glucosaminyl (N-acetyl) transferase 1, core 2513 0.01264 2.21 up Mm.218317 4930553M18Rik 104639_i_at AI464596 RIKEN cDNA 4930553M18 gene514 0.01270 1.64 up Mm.140380 Rpl23 161498_at AV099015 ribosomal protein L23515 0.01270 2.31 down Mm.201898 AU018122 94413_at AW121487 expressed sequence AU018122516 0.01277 2.03 down Mm.200358 Tcf7 97994_at AI019193 transcription factor 7, T-cell specific517 0.01280 1.77 down Mm.200319 D2Abb2e 104501_at AI849048 DNA segment, Chr 2, Abbott 2 expressed518 0.01281 5.67 up Mm.26006 AU014713 103992_f_at AA636966 expressed sequence AU014713519 0.01287 3.40 up Mm.203883 AA408556 160974_at AW108045 expressed sequence AA408556520 0.01290 2.48 down Mm.21596 EDEM 104065_at AW212878 ER alpha-mannosidase like521 0.01290 4.90 up Mm.26775 Mrpl36 161488_r_at AV080549 mitochondrial ribosomal protein L36522 0.01296 3.78 up Mm.183034 AA617404 162406_f_at AV313012 expressed sequence AA617404523 0.01300 1.68 up Mm.196126 2810025E10Rik 94480_at AW260202 RIKEN cDNA 2810025E10 gene524 0.01303 2.13 up Mm.21826 Timm13a 94012_at AI848685 translocase of inner mitochondrial membrane 13 homolog a (yeast)525 0.01307 2.18 up Mm.9714 Gdf9 160567_at L06444 growth differentiation factor 9526 0.01312 1.46 up Mm.262 Arhc 162468_at AV064502 ras homolog 9 (RhoC)527 0.01315 3.82 up Mm.159237 9130002K18Rik 98577_f_at Y12713 RIKEN cDNA 9130002K18 gene528 0.01322 3.85 up Mm.24506 AA409164 160712_r_at AI837948 expressed sequence AA409164529 0.01322 1.45 up Mm.6712 Des 100997_at L22550 desmin530 0.01325 3.15 up Mm.30142 D15Wsu77e 97920_at AA755126 DNA segment, Chr 15, Wayne State University 77, expressed531 0.01326 1.71 down Mm.219659 Hist2 93067_f_at U62674 histone gene complex 2532 0.01329 3.38 down Mm.155711 Ceacam2 101908_s_at AF101164 CEA-related cell adhesion molecule 2533 0.01333 2.11 up Mm.1235 F9 102291_at M23109 coagulation factor IX534 0.01334 2.06 down Mm.16323 Eif4a2 93089_at X12507 eukaryotic translation initiation factor 4A2535 0.01334 1.80 down Mm.21905 Rab2 94031_at X95403 RAB2, member RAS oncogene family536 0.01349 3.02 up Mm.5781 DXErtd223e 101601_at C79025 DNA segment, Chr X, ERATO Doi 223, expressed537 0.01350 1.71 up Mm.205855 D13Wsu123e 94450_at AI854202 DNA segment, Chr 13, Wayne State University 123, expressed538 0.01356 3.33 up Mm.14768 Rex3 93020_at AF051347 reduced expression 3539 0.01361 1.75 down Mm.206206 Ncdn-pending 104095_at AI843152 neurochondrin540 0.01368 1.42 down Mm.200342 AI787263 103845_at AI839005 expressed sequence AI787263Page 6 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description541 0.01369 1.53 down Mm.2895 D13Wsu50e 94502_at AW125724 DNA segment, Chr 13, Wayne State University 50, expressed542 0.01370 1.78 down Mm.218873 3110054G10Rik 103315_at AW120526 RIKEN cDNA 3110054G10 gene543 0.01373 1.54 down Mm.21520 Mm.21520 104052_at AI840921 Mus musculus, Similar to ribosomal protein L34 pseudogene 1, clone MGC:6544 0.01381 1.98 up Mm.29733 Ldb3 160354_at AJ005621 LIM domain binding 3545 0.01382 1.81 down Mm.35853 Comt 98535_at AF076156 catechol-O-methyltransferase546 0.01382 1.93 up Mm.5289 Gapd 101214_f_at M32599 glyceraldehyde-3-phosphate dehydrogenase547 0.01389 1.87 down Mm.14825 Idh3g 93029_at U68564 isocitrate dehydrogenase 3 (NAD+), gamma548 0.01394 1.86 up Mm.180299 D16Wsu109e 95431_at AA623426 DNA segment, Chr 16, Wayne State University 109, expressed549 0.01396 4.03 up Mm.7956 Rgs7 93645_at AF011360 regulator of G protein signaling 7550 0.01400 2.36 down Mm.255 Hoxb9 103952_at M34857 homeo box B9551 0.01402 1.81 up Mm.7521 Ran 101254_at L32751 RAN, member RAS oncogene family552 0.01403 3.99 up Mm.27757 Bmp1 95557_at L24755 bone morphogenetic protein 1553 0.01405 1.68 up Mm.10734 Aoc3 102327_at AF078705 amine oxidase, copper containing 3554 0.01407 1.88 down Mm.2315 AI447560 103531_f_at AI049144 expressed sequence AI447560555 0.01409 1.53 down Mm.24738 Mm.24738 103767_f_at AA675006 ESTs556 0.01415 1.95 up Mm.103 Hkp1 92568_at M74555 house-keeping protein 1557 0.01416 1.67 up Mm.197601 Hspe1 92829_at U09659 heat shock 10 kDa protein 1 (chaperonin 10)558 0.01421 3.09 down Mm.29151 Herpud1 95057_at AI846938 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-lik559 0.01422 1.76 down Mm.4077 Mm.4077 92397_at AW123016 ESTs560 0.01424 6.50 up Mm.279 1110019N10Rik 162471_i_at AV071208 RIKEN cDNA 1110019N10 gene561 0.01432 4.95 up Mm.27584 AW547774 161000_i_at AA275196 expressed sequence AW547774562 0.01433 1.76 up Mm.153758 0610040H15Rik 162470_at AV070263 RIKEN cDNA 0610040H15 gene563 0.01434 1.88 down Mm.2777 Tpd52 160249_at U44426 tumor protein D52564 0.01439 2.87 down Mm.193097 Mm.193097 98507_at AI834950 Mus musculus, Similar to nuclear receptor subfamily 1, group D, member 1,565 0.01445 1.86 down Mm.29010 Mbc2 96767_at AF098633 membrane bound C2 domain containing protein566 0.01453 2.06 down Mm.35628 Fut8 98143_at AB025198 fucosyltransferase 8567 0.01454 3.05 down Mm.205520 Mm.205520 97826_at AI465965 Mus musculus, clone IMAGE:4988271, mRNA, partial cds568 0.01455 2.44 up Mm.24609 AW495713 104727_at AI836317 expressed sequence AW495713569 0.01458 1.72 down Mm.15571 App 93063_at U82624 amyloid beta (A4) precursor protein570 0.01460 1.39 down Mm.22117 Polr2g 94073_at AI836182 polymerase (RNA) II (DNA directed) polypeptide G571 0.01463 1.38 down Mm.42948 Prdx2 100331_g_at AF032714 peroxiredoxin 2572 0.01466 3.49 up Mm.1805 F8 94799_at L05573 coagulation factor VIII573 0.01467 1.51 up Mm.22687 Nup62 160167_at AW121948 nucleoporin 62574 0.01468 2.47 up Mm.7952 Peg3 96765_at AW120874 paternally expressed 3575 0.01469 6.48 up Mm.19353 LOC56304 100721_f_at U10410 recombinant antineuraminidase single chain Ig VH and VL domains576 0.01469 2.29 up Mm.5244 Crem 100533_s_at M60285 cAMP responsive element modulator577 0.01470 2.24 down Mm.27575 Zfp68 95522_i_at AB024005 Zinc finger protein 68578 0.01470 2.00 up Mm.5980 Mm.5980 99825_at AA881307 ESTs, Weakly similar to NFM MOUSE NEUROFILAMENT TRIPLET M PRO579 0.01473 1.55 down Mm.24025 Stag2 92513_at AJ002636 stromal antigen 2580 0.01473 2.11 down Mm.22776 Eif3s8 94837_at U67328 eukaryotic translation initiation factor 3, subunit 8 (110 kDa)581 0.01473 1.41 down Mm.31979 Nudel-pending 98882_s_at AW047320 nuclear distribution gene E-like582 0.01479 2.54 up Mm.1593 Lcat 161759_r_at AV329184 lecithin cholesterol acyltransferase583 0.01479 3.75 up Mm.44238 Kcnj15 99974_at AI314692 potassium inwardly-rectifying channel, subfamily J, member 15584 0.01481 2.01 up Mm.196611 Syn1 93730_at AF085809 synapsin I585 0.01485 1.53 up Mm.2608 Bgn 162347_f_at AV166064 biglycan586 0.01487 1.65 down Mm.31076 0610040B21Rik 97492_at AW121746 RIKEN cDNA 0610040B21 gene587 0.01496 6.07 up Mm.5307 9130016M20Rik 99341_r_at AA087373 RIKEN cDNA 9130016M20 gene588 0.01498 2.30 up Mm.1390 Epha8 102682_at U72207 Eph receptor A8589 0.01500 3.75 up Mm.37811 Pou2f2 92305_s_at X53654 POU domain, class 2, transcription factor 2590 0.01500 1.72 down Mm.5400 Brd7 100543_s_at AA620184 bromodomain-containing 7591 0.01501 1.92 up Mm.103632 Rasl2-9 102821_s_at L32752 RAS-like, family 2, locus 9592 0.01502 2.92 down Mm.10763 Diap2 94127_at Y15910 diaphanous homolog 2 (Drosophila)593 0.01502 3.71 down Mm.1967 Tom1 103578_at AJ006972 target of myb1 homolog (chicken)594 0.01516 1.79 down Mm.28896 Sdccagg28 96735_at AW049732 serologically defined colon cancer antigen 28595 0.01518 2.07 up Mm.116 H2-Oa 98333_at AF100956 histocompatibility 2, O region alpha locus596 0.01525 2.68 up Mm.89123 Emb 162068_r_at AV309223 embigin597 0.01527 1.34 down Mm.21569 2700069E09Rik 93832_at AI854541 RIKEN cDNA 2700069E09 gene598 0.01542 1.58 down Mm.28332 Mm.28332 96158_at AW123477 Mus musculus, clone IMAGE:3708215, mRNA599 0.01548 3.49 up Mm.3266 Evi2 98026_g_at M34896 ecotropic viral integration site 2600 0.01549 1.96 down Mm.4876 Rcn 160896_at D13003 reticulocalbin601 0.01551 2.14 up Mm.29911 3200001M24Rik 96300_f_at AI854238 RIKEN cDNA 3200001M24 gene602 0.01554 2.64 down Mm.195848 Amd2 100323_at Z23077 S-adenosylmethionine decarboxylase 2603 0.01562 2.28 down Mm.27084 C76297 96529_at AW122059 expressed sequence C76297604 0.01570 2.48 up Mm.42099 Roc2-pending 102083_at AF084463 GTP-binding protein Roc2605 0.01578 1.88 down Mm.1391 Gata2 102789_at AB000096 GATA binding protein 2606 0.01584 2.09 down Mm.25044 Fliih 97593_f_at C79694 flightless I homolog (Drosophila)607 0.01584 1.43 up Mm.6424 Itgb5 161786_f_at AV363187 integrin beta 5608 0.01586 2.83 up Mm.42081 Mm.42081 102077_at AF039839 Mus musculus adriamycin-resistant related protein (Arr) mRNA, complete cd609 0.01589 8.34 up Mm.38315 Mm.38315 92321_r_at AA415783 ESTs, Weakly similar to ZF26 MOUSE ZINC FINGER PROTEIN 26 [M.musc610 0.01590 2.39 down Mm.34106 AI467657 92202_g_at AI553024 expressed sequence AI467657611 0.01596 1.78 up Mm.39130 2210402A09Rik 99093_at AI852864 RIKEN cDNA 2210402A09 gene612 0.01597 1.72 down Mm.28626 2410018G23Rik 98921_at AW125612 RIKEN cDNA 2410018G23 gene613 0.01599 1.39 down Mm.2137 Sin3b 93789_s_at AF038848 transcriptional regulator, SIN3B (yeast)614 0.01605 2.56 up Mm.2793 Siat4c 95599_at D28941 sialyltransferase 4C (beta-galactosidase alpha-2,3-sialytransferase)615 0.01605 2.28 up Mm.27261 R75501 161193_r_at AV241177 expressed sequence R75501616 0.01605 3.03 up Mm.23898 Mm.23898 95398_at AI447945 ESTs617 0.01612 6.15 up Mm.4668 Mpo 100414_s_at X15313 myeloperoxidase618 0.01615 2.33 up Mm.89843 Spi1-4 93109_f_at M75718 serine protease inhibitor 1-4619 0.01615 1.70 down Mm.29529 C77668 97329_at AW124061 expressed sequence C77668620 0.01619 2.82 up Mm.43677 Apoa2 99648_at X62772 apolipoprotein A-II621 0.01624 3.14 up Mm.45765 2810417H13Rik 93952_r_at AA409629 RIKEN cDNA 2810417H13 gene622 0.01629 3.23 up Mm.12429 Cbfa2t3h 102397_at AF038029 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 homolog623 0.01631 3.02 up Mm.155714 Myh7 98616_f_at AJ223362 myosin, heavy polypeptide 7, cardiac muscle, beta624 0.01631 3.58 up Mm.31099 Art1 104638_at U31510 ADP-ribosyltransferase 1625 0.01632 1.43 down Mm.1800 Mm.1800 94796_at AA710643 ESTs626 0.01636 3.98 up Mm.2766 Pva 96720_f_at X59382 parvalbumin627 0.01637 1.85 down Mm.25836 Cldn8 93146_at AF087826 claudin 8628 0.01641 1.84 up Mm.4113 Rae1 161455_r_at AV295434 RAE1 RNA export 1 homolog (S. pombe)629 0.01643 4.36 up Mm.42203 Knsl1 99541_at AJ223293 kinesin-like 1630 0.01644 3.01 up Mm.99965 D1Lub1 101846_r_at M55219 DNA segment, Chr 1, Lubeck 1Page 7 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description631 0.01647 3.02 up Mm.10091 Pkig 92549_at U97170 protein kinase inhibitor, gamma632 0.01647 1.66 up Mm.18968 AU041772 103427_at AW123223 expressed sequence AU041772633 0.01649 1.66 down Mm.6967 Bcl2l2 160920_at U59746 Bcl2-like 2634 0.01652 3.77 up Mm.121889 Mm.121889 101686_at D18410 ESTs635 0.01654 1.37 down Mm.4859 1110060F11Rik 160518_at AI048434 RIKEN cDNA 1110060F11 gene636 0.01659 1.50 down Mm.30113 Ndufs3 96899_at AW123802 NADH dehydrogenase (ubiquinone) Fe-S protein 3637 0.01660 4.80 down Mm.42012 Lama3 97790_s_at X84014 laminin, alpha 3638 0.01669 2.54 up Mm.7980 Prkcc 93648_at L28035 protein kinase C, gamma639 0.01673 2.13 up Mm.25877 Phtf 94406_at AJ242864 putative homeodomain transcription factor640 0.01674 2.00 down Mm.24790 4933432B13Rik 103774_at AW108350 RIKEN cDNA 4933432B13 gene641 0.01675 2.58 up Mm.5033 Mm.5033 98837_at AI462038 ESTs, Moderately similar to RELX MOUSE PRORELAXIN PRECURSOR [M642 0.01683 2.26 up Mm.142380 Rpl27a 101680_at X05021 ribosomal protein L27a643 0.01689 1.43 down Mm.29118 Mm.29118 95042_at AI839770 Mus musculus, Similar to hypothetical protein, clone MGC:6903 IMAGE:2655644 0.01691 3.91 up Mm.30502 2210039B01Rik 100920_at AA822539 RIKEN cDNA 2210039B01 gene645 0.01694 6.56 up Mm.3404 Meox1 98419_at Z15103 mesenchyme homeobox 1646 0.01694 1.46 down Mm.28212 Sepr 160275_at AI840996 selenoprotein R647 0.01700 4.57 up Mm.42095 Sfrp4 92469_at AF117709 secreted frizzled-related sequence protein 4648 0.01703 1.78 down Mm.44488 1110031K21Rik 95374_f_at AI413993 RIKEN cDNA 1110031K21 gene649 0.01704 2.66 up Mm.41653 Rlbp1 92435_at AF084642 retinaldehyde binding protein 1650 0.01706 1.87 down Mm.5326 2610022K04Rik 93165_at AW121327 RIKEN cDNA 2610022K04 gene651 0.01719 4.21 up Mm.689 Acvr1 93460_at L15436 activin A receptor, type 1652 0.01722 5.43 up Mm.29008 Iigp-pending 96764_at AJ007971 interferon-inducible GTPase653 0.01727 1.68 down Mm.7050 5730405M13Rik 160922_at AA980810 RIKEN cDNA 5730405M13 gene654 0.01729 1.73 down Mm.4184 Zfp1 92444_f_at X16493 zinc finger protein 1655 0.01731 1.76 down Mm.23827 Mm.23827 104560_at AW125634 Mus musculus, Similar to putative mitochondrial solute carrier, clone MGC:37656 0.01740 1.55 down Mm.29870 Itm3-pending 96283_at AI849180 integral membrane protein 3657 0.01744 1.54 down Mm.18962 Catna1 93364_at X59990 catenin alpha 1658 0.01750 1.49 down Mm.155712 Stx5a 96076_at AW121716 syntaxin 5A659 0.01752 1.64 down Mm.30256 2810422B04Rik 160400_at AI853616 RIKEN cDNA 2810422B04 gene660 0.01753 1.74 down Mm.27647 1110003E01Rik 96716_at AW121102 RIKEN cDNA 1110003E01 gene661 0.01764 2.91 up Mm.46048 Sh3bp5 98766_at AB016835 SH3-domain binding protein 5 (BTK-associated)662 0.01764 1.73 up Mm.29904 Mrpl15 96296_at AI843685 mitochondrial ribosomal protein L15663 0.01765 1.52 down Mm.34497 2510002C21Rik 98440_at AA596710 RIKEN cDNA 2510002C21 gene664 0.01766 2.39 up Mm.41038 Mm.41038 97754_at AI841211 ESTs, Weakly similar to ZINC FINGER PROTEIN MLZ-4 [M.musculus]665 0.01769 2.67 up Mm.22662 Krt1-10 94321_at V00830 keratin complex 1, acidic, gene 10666 0.01779 2.28 down Mm.31392 AI325977 104648_at AI844597 expressed sequence AI325977667 0.01780 3.40 up Mm.4695 Nat2 92746_at U37249 N-acetyltransferase 2 (arylamine N-acetyltransferase)668 0.01798 4.58 up Mm.196591 Spi1-3 100329_at X00945 serine protease inhibitor 1-3669 0.01804 1.78 down Mm.29655 Mm.29655 95692_at AI852514 ESTs, Highly similar to SR68_HUMAN SIGNAL RECOGNITION PARTICLE670 0.01806 1.49 down Mm.22130 Rpn2 94077_f_at D31717 ribophorin II671 0.01810 3.19 up Mm.43330 0610025G13Rik 99627_r_at AA638667 RIKEN cDNA 0610025G13 gene672 0.01823 2.83 up Mm.13824 Vhlh 102676_at U12570 von Hippel-Lindau syndrome homolog673 0.01834 2.55 down Mm.3153 Myh11 97990_at D85923 myosin heavy chain 11, smooth muscle674 0.01835 1.81 down Mm.4097 Rxrip110 99464_at U22015 retinoid X receptor interacting protein 110675 0.01839 1.63 up Mm.28803 1010001J12Rik 94455_at AA795062 RIKEN cDNA 1010001J12 gene676 0.01841 2.10 up Mm.14627 Plscr1 102839_at D78354 phospholipid scramblase 1677 0.01843 2.42 up Mm.2514 Grca 161771_r_at AV341612 gene rich cluster, A gene678 0.01844 3.84 up Mm.88841 Olfr37a 96999_at AJ133424 olfactory receptor 37a679 0.01849 1.55 down Mm.34695 Arpc1a 95144_at AB024984 actin related protein 2/3 complex, subunit 1A (41 kDa)680 0.01853 2.08 up Mm.57153 Soat2 97132_at AA189890 sterol O-acyltransferase 2681 0.01856 1.41 down Mm.14287 Hspa1l 96761_at AF109906 heat shock 70kD protein 1-like682 0.01859 2.00 up Mm.37835 Rpl7 97696_r_at M29015 ribosomal protein L7683 0.01861 2.80 down Mm.29580 Scgn10 95668_at AI840972 superiorcervical ganglia, neural specific 10684 0.01862 2.87 down Mm.10812 Pde9a 102338_at AF031147 phosphodiesterase 9A685 0.01862 1.45 down Mm.44174 Mrpl43 99674_at AW060297 mitochondrial ribosomal protein L43686 0.01864 1.51 down Mm.20290 AW536573 103630_at AI844089 expressed sequence AW536573687 0.01865 1.83 down Mm.28917 1810045K17Rik 92189_at AI846017 RIKEN cDNA 1810045K17 gene688 0.01871 1.55 up Mm.17980 Hmox1 160101_at X56824 heme oxygenase (decycling) 1689 0.01877 1.46 down Mm.2040 Glb1 103647_at M57734 galactosidase, beta 1690 0.01879 1.68 down Mm.10313 Ankhzn 102054_at AB011370 ankyrin repeat hooked to zinc finger motif691 0.01881 2.41 up Mm.29938 Ifi1 97409_at U19119 interferon inducible protein 1692 0.01883 2.42 up Mm.68157 Mm.68157 161149_r_at AV222871 ESTs, Weakly similar to JC7182 Na+-dependent vitamin C [H.sapiens]693 0.01885 1.54 down Mm.29633 1810008O21Rik 97356_at AI839653 RIKEN cDNA 1810008O21 gene694 0.01886 3.77 up Mm.26584 AA960287 94441_at AW061237 expressed sequence AA960287695 0.01887 2.32 up Mm.3177 Ly64 162041_f_at AV374719 lymphocyte antigen 64696 0.01892 1.68 down Mm.972 Uqcrc1 101989_at AW125380 ubiquinol-cytochrome c reductase core protein 1697 0.01894 3.63 up Mm.22248 Igfbp4 101570_at X76066 insulin-like growth factor binding protein 4698 0.01894 1.61 down Mm.29915 Mm.29915 96302_at AA711516 Mus musculus, clone MGC:36924 IMAGE:4945988, mRNA, complete cds699 0.01903 2.83 up Mm.3446 Dck 98071_f_at X77731 deoxycytidine kinase700 0.01910 5.16 up Mm.5715 C78532 101232_at C78532 expressed sequence C78532701 0.01913 1.47 down Mm.30195 R75577 96943_at AW125234 expressed sequence R75577702 0.01915 2.40 up Mm.10081 Gli 103366_at AI117236 GLI-Kruppel family member GLI703 0.01927 1.87 up Mm.180895 3110001K13Rik 104212_at AA607767 RIKEN cDNA 3110001K13 gene704 0.01936 1.98 up Mm.27449 AI853703 104188_at AI853703 expressed sequence AI853703705 0.01936 3.94 up Mm.4861 Tnfsf5 98812_at X65453 tumor necrosis factor (ligand) superfamily, member 5706 0.01937 1.56 down Mm.22072 Noc4 96641_at AW060674 neighbor of Cox4707 0.01940 2.69 up Mm.24816 F2r 92267_at L03529 coagulation factor II (thrombin) receptor708 0.01945 2.12 down Mm.39716 Sec63 99350_at C76102 SEC63 (S. cerevisiae)709 0.01946 1.77 down Mm.39472 Mm.39472 160424_f_at AI846851 Mus musculus farnesyl pyrophosphate synthase (Fpps) mRNA, complete cd710 0.01949 1.85 down Mm.42944 Tceb1l 99607_at Z47088 transcription elongation factor B (SIII), polypeptide 1 (15 kDa),-like711 0.01949 2.09 down Mm.200644 R75096 161006_at AI853978 expressed sequence R75096712 0.01956 2.25 down Mm.13148 AI450991 102646_at AW122284 expressed sequence AI450991713 0.01960 2.97 up Mm.3066 Pax1 96595_at M20978 paired box gene 1714 0.01960 2.29 down Mm.46014 shrm 100024_at AI641895 shroom715 0.01960 2.63 down Mm.8034 Pbsn 94632_at AF005204 probasin716 0.01966 1.89 up Mm.91981 Mm.91981 161842_r_at AV329374 ESTs717 0.01972 1.57 down Mm.29866 Mm.29866 160366_at AI846422 Mus musculus, clone MGC:27590 IMAGE:4501468, mRNA, complete cds718 0.01974 1.79 up Mm.30069 1200003J11Rik 96873_at AI843287 RIKEN cDNA 1200003J11 gene719 0.01980 1.94 up Mm.57249 Dyrk1b 102584_at Y18280 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b720 0.01991 1.76 up Mm.23884 1300011P19Rik 160186_at AI847282 RIKEN cDNA 1300011P19 genePage 8 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description721 0.01996 1.63 down Mm.21451 4933434E20Rik 104038_at AI843511 RIKEN cDNA 4933434E20 gene722 0.01998 1.65 up Mm.28773 0610016J10Rik 98959_at AW120623 RIKEN cDNA 0610016J10 gene723 0.01999 1.58 down Mm.6874 Surf1 101031_at M14689 surfeit gene 1724 0.02000 2.97 down Mm.24179 AW061228 95897_at AW061228 expressed sequence AW061228725 0.02002 1.54 down Mm.28688 Sars1 98936_at AI837395 seryl-aminoacyl-tRNA synthetase 1726 0.02005 2.52 up Mm.11434 5730403J10Rik 102354_at AI049398 RIKEN cDNA 5730403J10 gene727 0.02007 2.58 down Mm.20916 Wfs1 103824_at AF084482 Wolfram syndrome 1 homolog (human)728 0.02009 1.82 down Mm.29473 Copz1 95149_at AW121088 coatomer protein complex, subunit zeta 1729 0.02015 1.52 down Mm.6577 Vti1b-pending 100964_at AF035208 vesicle transport through interaction with t-SNAREs 1b homolog730 0.02028 3.10 up Mm.2183 Lsp1 161914_s_at AV122642 lymphocyte specific 1731 0.02036 2.43 down Mm.116866 LOC170938 100713_at AB020542 zinc finger protein s11-6732 0.02037 2.62 up Mm.195085 Tyms-ps 100756_r_at M30774 thymidylate synthase, pseudogene733 0.02038 2.02 down Mm.92529 Ubqln2 102002_at AI836406 ubiquilin 2734 0.02063 1.42 up Mm.23826 BC003940 104559_at AI848162 phosphotyrosyl phosphatase activator735 0.02067 2.41 down Mm.4317 Pigr 99926_at AB001489 polymeric immunoglobulin receptor736 0.02072 1.51 down Mm.30099 Mm.30099 160386_at AI835981 Mus musculus, Similar to cisplatin resistance related protein CRR9p, clone M737 0.02075 1.70 down Mm.10409 Golga4 102060_at AF051357 golgi autoantigen, golgin subfamily a, 4738 0.02076 2.38 down Mm.153748 5031422I09Rik 96187_at AI837021 RIKEN cDNA 5031422I09 gene739 0.02078 1.78 down Mm.200774 Mgea6 104033_at AI841996 meningioma expressed antigen 6 (coiled-coil proline-rich)740 0.02079 1.59 up Mm.28579 1110066C01Rik 98904_at AW061339 RIKEN cDNA 1110066C01 gene741 0.02082 2.67 up Mm.41552 Mm.41552 96531_at AA153773 Mus musculus, clone MGC:28734 IMAGE:4460615, mRNA, complete cds742 0.02090 3.76 up Mm.25069 Mm.25069 95997_at C79758 ESTs743 0.02091 2.13 up Mm.2408 C3ar1 103707_at U77461 complement component 3a receptor 1744 0.02096 2.12 up Mm.160237 Mm.160237 97680_at M65237 Mouse murinoglobulin (MUG3) mRNA, last 2 exons745 0.02102 1.85 up Mm.15537 Cyp1a2 102998_at X04283 cytochrome P450, 1a2, aromatic compound inducible746 0.02103 3.22 up Mm.4328 AA536748 98345_at AA674593 expressed sequence AA536748747 0.02106 3.24 up Mm.20857 Zfp125 103267_i_at AI154710 zinc finger protein 125748 0.02112 1.75 up Mm.1693 Hmgb2 93250_r_at X67668 high mobility group box 2749 0.02117 2.12 up Mm.202767 AA408257 161092_at AA408501 expressed sequence AA408257750 0.02119 2.80 up Mm.30008 2900055D03Rik 96355_at AI839395 RIKEN cDNA 2900055D03 gene751 0.02129 1.75 down Mm.214958 Srebf1 93264_at AI843895 sterol regulatory element binding factor 1752 0.02129 3.49 up Mm.137 Scya6 92849_at M58004 small inducible cytokine A6753 0.02133 2.03 up Mm.21070 AI504353 103853_at AI845664 expressed sequence AI504353754 0.02136 2.72 down Mm.3903 Rasd1 99032_at AF009246 RAS, dexamethasone-induced 1755 0.02136 3.52 up Mm.12965 Cst7 102638_at AB015224 cystatin F (leukocystatin)756 0.02140 2.59 up Mm.1263 Serpine1 94147_at M33960 serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activato757 0.02155 1.86 up Mm.28140 AI447804 161791_r_at AV363719 expressed sequence AI447804758 0.02157 1.76 up Mm.25192 Mm.25192 96493_at AA682091 ESTs759 0.02159 6.99 up Mm.57008 Art2b 99402_at X87612 ADP-ribosyltransferase 2b760 0.02163 1.75 down Mm.45233 2400003B06Rik 100074_at AW046723 RIKEN cDNA 2400003B06 gene761 0.02164 1.99 up Mm.1 S100a10 92539_at M16465 S100 calcium binding protein A10 (calpactin)762 0.02164 1.94 down Mm.8739 Sgce 101861_at AF031919 sarcoglycan, epsilon763 0.02171 1.78 down Mm.27680 AW489456 93482_at AI117835 expressed sequence AW489456764 0.02173 2.32 up Mm.18923 Mcmd7 93356_at D26091 mini chromosome maintenance deficient 7 (S. cerevisiae)765 0.02181 1.90 down Mm.28336 0610010I20Rik 97869_at AI844043 RIKEN cDNA 0610010I20 gene766 0.02183 2.16 down Mm.214583 Prosc 101568_at AW227620 proline synthetase co-transcribed767 0.02185 2.69 up Mm.6279 Rai2 93399_at X76652 retinoic acid induced 2768 0.02189 1.60 up Mm.297 Actb 101578_f_at M12481 actin, beta, cytoplasmic769 0.02192 4.06 up Mm.2627 Xrcc5 161686_i_at AV217007 X-ray repair complementing defective repair in Chinese hamster cells 5770 0.02193 2.30 up Mm.13356 3110079L04Rik 92840_at AA683712 RIKEN cDNA 3110079L04 gene771 0.02200 1.80 up Mm.21473 1190017B19Rik 160135_at AW122914 RIKEN cDNA 1190017B19 gene772 0.02203 2.36 down Mm.41629 2310004N24Rik 99157_at AI846684 RIKEN cDNA 2310004N24 gene773 0.02205 2.63 up Mm.214943 4921538B03Rik 96193_at Z38011 RIKEN cDNA 4921538B03 gene774 0.02206 1.94 down Mm.29968 Rab3d 97415_at M89777 RAB3D, member RAS oncogene family775 0.02207 1.86 up Mm.1848 Cd3e 102971_at M23376 CD3 antigen, epsilon polypeptide776 0.02208 1.42 up Mm.35777 Mm.35777 97176_at AI645547 ESTs777 0.02210 2.07 down Mm.2442 Cai 95423_at Y00884 calcium binding protein, in<strong>test</strong>inal778 0.02219 3.27 up Mm.14092 Foxc2 102800_at X74040 forkhead box C2779 0.02228 1.68 down Mm.16763 Aldo1 160090_f_at Y00516 aldolase 1, A isoform780 0.02235 1.35 up Mm.589 Gpi1 100573_f_at M14220 glucose phosphate isomerase 1 complex781 0.02239 2.03 down Mm.140619 Egln1 95468_at AI850202 EGL nine homolog 1 (C. elegans)782 0.02242 2.26 up Mm.200920 Rps28 98086_r_at U11248 ribosomal protein S28783 0.02243 4.91 up Mm.14300 Xmr 102818_at X72697 Xlr-related, meiosis regulated784 0.02245 1.73 down Mm.46412 1810005H09Rik 97798_at AW121496 RIKEN cDNA 1810005H09 gene785 0.02248 2.88 up Mm.189988 Mm.189988 161803_r_at AV350751 EST786 0.02250 2.21 down Mm.1211 Tiam1 102283_at U05245 T-cell lymphoma invasion and metastasis 1787 0.02254 1.83 down Mm.24437 Vps4a 104711_at AW122109 vacuolar protein sorting protein 4a788 0.02261 1.94 up Mm.21612 C80611 104068_at AI845621 expressed sequence C80611789 0.02263 1.58 down Mm.4593 Ugalt2 100091_at D87990 UDP-galactose translocator 2790 0.02266 2.97 down Mm.2017 Etv6 160119_at AI845538 ets variant gene 6 (TEL oncogene)791 0.02271 3.39 up Mm.23520 Spz1-pending 104104_at AA666904 spermatogenic Zip 1792 0.02287 2.48 up Mm.1923 Pola1 103207_at D13543 DNA polymerase alpha 1, 180 kDa793 0.02288 1.62 up Mm.29762 C80501 97383_at AI848623 expressed sequence C80501794 0.02294 2.22 down Mm.21485 2610102M01Rik 104045_at AW122372 RIKEN cDNA 2610102M01 gene795 0.02294 1.80 up Mm.25013 1110002C08Rik 94339_at AI841330 RIKEN cDNA 1110002C08 gene796 0.02296 1.42 down Mm.31018 0610009N12Rik 98533_at AI854779 RIKEN cDNA 0610009N12 gene797 0.02299 2.17 down Mm.30074 AA409584 96879_at AI852338 expressed sequence AA409584798 0.02302 2.61 up Mm.214647 Hmx3 92977_s_at X75330 H6 homeo box 3799 0.02303 3.00 up Mm.6381 AW112010 100944_at AA958903 expressed sequence AW112010800 0.02307 2.02 up Mm.57110 Col4a4 101774_at Z35167 procollagen, type IV, alpha 4801 0.02307 2.72 up Mm.517 Mfng 100508_at AF015769 manic fringe homolog (Drosophila)802 0.02313 1.59 up Mm.87062 Mrps25 102128_f_at C77227 mitochondrial ribosomal protein S25803 0.02323 3.77 up Mm.2619 Cck 96055_at X59520 cholecystokinin804 0.02325 2.41 down Mm.35727 Rab11b 98150_at L26528 RAB11B, member RAS oncogene family805 0.02327 2.78 up Mm.983 Il3 94086_at K01668 interleukin 3806 0.02328 3.09 up Mm.25652 Gjb6 94391_at AW123650 gap junction membrane channel protein beta 6807 0.02329 3.01 up Mm.28042 9030623C06Rik 95621_at AA606367 RIKEN cDNA 9030623C06 gene808 0.02337 2.55 up Mm.12669 Tex19 102418_at AA793009 <strong>test</strong>is expressed gene 19809 0.02339 1.87 down Mm.155579 Col4a5 93220_at Z35168 procollagen, type IV, alpha 5810 0.02340 1.54 down Mm.63479 Slc15a2 103918_at AI846682 solute carrier family 15 (H+/peptide transporter), member 2Page 9 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description811 0.02342 2.43 up Mm.33796 Mm.33796 92180_at AI851599 ESTs, Weakly similar to HISTONE H1.4 [M.musculus]812 0.02344 1.52 down Mm.17898 Cirbp 93284_at D78135 cold inducible RNA binding protein813 0.02345 1.29 up Mm.35650 2700085A14Rik 98144_f_at AI844321 RIKEN cDNA 2700085A14 gene814 0.02345 2.44 down Mm.200446 AW540062 161073_at AI846304 expressed sequence AW540062815 0.02349 1.77 up Mm.1749 Serf1 103094_at AI036894 small EDRK-rich factor 1816 0.02349 1.56 down Mm.204893 AI430822 97386_at AI853294 expressed sequence AI430822817 0.02351 2.41 up Mm.34946 C80197 97146_g_at C80197 expressed sequence C80197818 0.02353 1.51 down Mm.27942 Trrp4ap-pending 95602_at AI848135 transient receptor protein 4, associated protein819 0.02356 2.12 up Mm.2011 Gstm1 161633_r_at AV003177 glutathione S-transferase, mu 1820 0.02358 1.56 down Mm.35856 Pts 160844_at AF043225 6-pyruvoyl-tetrahydropterin synthase821 0.02363 5.55 up Mm.25547 0610037B21Rik 161473_f_at AV031985 RIKEN cDNA 0610037B21 gene822 0.02372 2.30 down Mm.87858 Bglap1 100336_s_at L24431 bone gamma carboxyglutamate protein 1823 0.02376 1.81 down Mm.22087 1700001E16Rik 94067_at AW212399 RIKEN cDNA 1700001E16 gene824 0.02382 1.95 up Mm.3297 Zfp35 98032_at M36146 zinc finger protein 35825 0.02385 2.20 up Mm.29096 Nrbf1 160798_at AW046483 nuclear receptor binding factor 1826 0.02389 1.47 down Mm.4338 Psen2 99930_s_at U57325 presenilin 2827 0.02396 2.80 up Mm.47747 Mm.47747 162330_f_at AV089248 EST828 0.02398 1.73 down Mm.9052 Pgrmc1 101585_at AF042491 progesterone receptor membrane component 1829 0.02399 1.77 down Mm.154307 0610009H04Rik 101518_at U38981 RIKEN cDNA 0610009H04 gene830 0.02405 2.47 up Mm.24219 1810037I17Rik 102234_at AW047207 RIKEN cDNA 1810037I17 gene831 0.02415 1.76 down Mm.24260 AU024582 104624_at AI851539 expressed sequence AU024582832 0.02416 1.44 up Mm.29247 2310009N05Rik 160801_at AW061073 RIKEN cDNA 2310009N05 gene833 0.02418 3.02 up Mm.196526 Arf6 100462_at D87903 ADP-ribosylation factor 6834 0.02419 6.65 up Mm.8038 Zap70 93662_s_at AI386093 zeta-chain (TCR) associated protein kinase (70kD)835 0.02421 2.51 up Mm.20436 Fgd3 102619_at AF017369 faciogenital dysplasia homolog 3836 0.02423 1.63 up Mm.23965 Efnb3 94160_at AF025288 ephrin B3837 0.02426 2.37 up Mm.25091 D4Ertd335e 96392_at C80868 DNA segment, Chr 4, ERATO Doi 335, expressed838 0.02432 3.77 up Mm.31387 Nr5a1 100700_s_at AB000490 nuclear receptor subfamily 5, group A, member 1839 0.02443 4.09 up Mm.27026 Clgn 104029_at U08373 calmegin840 0.02443 1.65 up Mm.70127 Rpl12 99778_at AU020239 ribosomal protein L12841 0.02454 2.12 up Mm.205045 AI324246 160663_at AW047871 expressed sequence AI324246842 0.02455 1.70 down Mm.29652 Gstz1 160350_at AW060750 glutathione transferase zeta 1 (maleylacetoacetate isomerase)843 0.02457 2.66 down Mm.4098 Sca10 99127_at X61506 spinocerebellar ataxia 10 homolog (human)844 0.02460 1.49 down Mm.27259 AL022610 94976_at AI845877 expressed sequence AL022610845 0.02467 1.78 up Mm.141773 1200009I24Rik 95357_at AI325802 RIKEN cDNA 1200009I24 gene846 0.02469 4.02 up Mm.41980 Ly94 97781_at AJ223765 lymphocyte antigen 94847 0.02470 1.72 up Mm.29931 Cdc20 96319_at AW061324 cell division cycle 20 homolog (S. cerevisiae)848 0.02473 2.32 up Mm.29082 1110037A17Rik 96784_at AW123269 RIKEN cDNA 1110037A17 gene849 0.02474 4.26 up Mm.3390 Myo1b 162008_r_at AV245773 myosin Ib850 0.02474 1.84 down Mm.24356 9130427A09Rik 93484_at AW061306 RIKEN cDNA 9130427A09 gene851 0.02475 1.48 down Mm.2507 Dj1-pending 95491_at AB015652 RNA binding protein regulatory subunit852 0.02478 1.61 down Mm.20927 Tgfb1i4 93728_at X62940 transforming growth factor beta 1 induced transcript 4853 0.02481 1.73 down Mm.26944 1700057K18Rik 94942_at AI854108 RIKEN cDNA 1700057K18 gene854 0.02484 1.57 up Mm.24091 1110001J03Rik 94907_f_at AW045632 RIKEN cDNA 1110001J03 gene855 0.02492 1.37 down Mm.196574 Grhpr 95084_f_at AI844995 glyoxylate reductase/hydroxypyruvate reductase856 0.02499 2.83 up Mm.20441 Atp2b2 95324_at AF053471 ATPase, Ca++ transporting, plasma membrane 2857 0.02499 2.43 up Mm.1114 Gla 160080_r_at U58105 galactosidase, alpha858 0.02501 1.49 down Mm.29340 Gclm 160335_at U95053 glutamate-cysteine ligase , modifier subunit859 0.02507 4.28 up Mm.35134 Atp2a1 98126_s_at X67140 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1860 0.02514 2.93 up Mm.33853 1600014J01Rik 97555_at AI851678 RIKEN cDNA 1600014J01 gene861 0.02516 2.99 up Mm.3628 AA409749 100742_at AA409749 expressed sequence AA409749862 0.02522 2.81 up Mm.1008 Ptgds 92545_f_at AB006361 prostaglandin D2 synthase (21 kDa, brain)863 0.02525 2.66 up Mm.4999 Ddr2 92969_at X76505 discoidin domain receptor family, member 2864 0.02526 1.40 down Mm.21606 Rtn3 93839_at AI854888 reticulon 3865 0.02530 1.51 up Mm.29646 0610010E05Rik 160349_at AI854839 RIKEN cDNA 0610010E05 gene866 0.02540 4.21 up Mm.3370 Scya5 98406_at AF065947 small inducible cytokine A5867 0.02544 1.40 down Mm.24593 4930558H15Rik 95445_at AW124194 RIKEN cDNA 4930558H15 gene868 0.02547 3.51 up Mm.206159 Pdxk 96519_at AI450876 pyridoxal (pyridoxine, vitamin B6) kinase869 0.02551 1.55 down Mm.957 Cops4 101976_at AF071314 COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thal870 0.02553 2.80 up Mm.1360 Gadd45b 161666_f_at AV138783 growth arrest and DNA-damage-inducible 45 beta871 0.02554 2.23 up Mm.31308 Entpd2 161821_f_at AV378405 ectonucleoside triphosphate diphosphohydrolase 2872 0.02555 1.64 down Mm.196581 Mapk1 93254_at AI839142 mitogen activated protein kinase 1873 0.02557 1.77 down Mm.22508 Mtx 161898_i_at AV108173 metaxin874 0.02558 1.71 down Mm.21514 C85457 93821_at AW046101 expressed sequence C85457875 0.02565 3.43 up Mm.21567 S100a8 103448_at M83218 S100 calcium binding protein A8 (calgranulin A)876 0.02567 1.69 up Mm.22353 1810029F08Rik 161888_r_at AV371196 RIKEN cDNA 1810029F08 gene877 0.02571 1.39 down Mm.25777 Inpp5b 94399_at AI843172 inositol polyphosphate-5-phosphatase, 75 kDa878 0.02579 3.24 up Mm.6718 Ifit1 100981_at U43084 interferon-induced protein with tetratricopeptide repeats 1879 0.02579 1.62 up Mm.7971 Foxb2 94618_at X92591 forkhead box B2880 0.02580 3.35 up Mm.38487 Mm.38487 97714_r_at W91600 ESTs, Weakly similar to TYROSINE-PROTEIN KINASE JAK3 [M.musculus]881 0.02583 2.03 up Mm.182692 Sh3glb1 98945_at AW125190 SH3-domain GRB2-like B1 (endophilin)882 0.02587 5.58 up Mm.22379 Mm.22379 161387_i_at AV253622 Mus musculus, Similar to hypothetical protein FLJ13213, clone MGC:28555883 0.02597 1.69 up Mm.33902 Gtpi-pending 98410_at AJ007972 interferon-g induced GTPase884 0.02599 2.44 up Mm.6149 AA673245 93375_at AA673487 expressed sequence AA673245885 0.02606 1.87 up Mm.16549 Pold1 103057_at AF024570 DNA polymerase delta 1, catalytic domain886 0.02607 1.85 down Mm.28297 BC002318 96155_at AW049359 hypothetical protein, MGC:8303887 0.02608 1.91 down Mm.5087 Fgf1 100494_at M30641 fibroblast growth factor 1888 0.02609 1.66 down Mm.200912 Prkab1 160808_at AI854287 protein kinase, AMP-activated, beta 1 non-catalytic subunit889 0.02609 1.84 up Mm.86541 Ccr4 93909_f_at X04120 carbon catabolite repression 4 homolog (S. cerevisiae)890 0.02616 5.90 up Mm.21983 Bhmt 94049_at AF033381 betaine-homocysteine methyltransferase891 0.02619 1.95 up Mm.13123 AI853584 102770_at M26385 expressed sequence AI853584892 0.02623 1.66 down Mm.10160 AA960172 160575_at AW045426 expressed sequence AA960172893 0.02625 7.69 up Mm.24053 AA986766 103702_i_at AI647632 expressed sequence AA986766894 0.02629 4.04 up Mm.46749 AI643885 99863_at AI608436 expressed sequence AI643885895 0.02638 2.06 up Mm.7165 1110014J22Rik 101387_at AI852646 RIKEN cDNA 1110014J22 gene896 0.02644 1.39 down Mm.206159 Pdxk 104320_at AI841777 pyridoxal (pyridoxine, vitamin B6) kinase897 0.02645 1.49 down Mm.6698 Sara 100635_at L20294 SAR1a gene homolog (S. cerevisiae)898 0.02647 2.37 down Mm.171337 Mm.171337 96054_f_at Y17345 Mus musculus mRNA for protein-tyrosine-phosphatase IF1899 0.02648 1.45 down Mm.28882 Hbs1l 94484_at AW227778 Hbs1-like (S. cerevisiae)900 0.02651 2.19 down Mm.2409 Adh1 94906_at M22679 alcohol dehydrogenase 1, complexPage 10 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description901 0.02656 3.75 up Mm.42124 Slfn2 92472_f_at AF099973 schlafen 2902 0.02657 1.81 up Mm.3110 Ktn1 97976_at L43326 kinectin 1903 0.02659 2.53 down Mm.21503 B3gnt1 160137_at AW260308 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1904 0.02663 1.55 down Mm.181237 0610007O07Rik 96653_at AI851762 RIKEN cDNA 0610007O07 gene905 0.02665 1.40 up Mm.2038 G3bp-pending 103642_at AB001927 Ras-GTPase-activating protein SH3-domain binding protein906 0.02674 2.50 up Mm.96903 Mm.96903 162278_r_at AV369255 EST907 0.02678 4.11 up Mm.46366 AV065366 162045_r_at AV376560 expressed sequence AV065366908 0.02684 1.85 down Mm.26282 Mm.26282 94423_at AW049551 Mus musculus, Similar to hypothetical protein from clone 643, clone MGC:79909 0.02690 2.47 down Mm.214950 Acta1 100381_at M12347 actin, alpha 1, skeletal muscle910 0.02691 1.63 up 99701_f_at AJ005560911 0.02692 1.44 down Mm.30092 1300002A08Rik 96890_at AW060971 RIKEN cDNA 1300002A08 gene912 0.02697 1.33 down Mm.1444 Cops7a 92874_f_at AF071316 COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis tha913 0.02698 2.09 up Mm.198246 AA987153 96026_at AA987153 expressed sequence AA987153914 0.02700 2.19 down Mm.22218 1300013N08Rik 104277_at AI834815 RIKEN cDNA 1300013N08 gene915 0.02708 2.85 up Mm.219620 Slc34a1 101552_at L33878 solute carrier family 34 (sodium phosphate), member 1916 0.02711 1.45 down Mm.3624 Guk1 98544_at U53514 guanylate kinase 1917 0.02715 2.04 down Mm.42193 Spin 92477_at AA681862 spindlin918 0.02715 1.46 down Mm.43760 Spc18-pending 99655_at AB025405 signal peptidase complex (18kD)919 0.02715 1.94 up Mm.19904 Bax 93536_at L22472 Bcl2-associated X protein920 0.02720 1.49 down Mm.30204 2610008L04Rik 96948_at AI845337 RIKEN cDNA 2610008L04 gene921 0.02724 1.75 down Mm.24779 Arhgef5 160977_at AA726063 Rho guanine nucleotide exchange factor (GEF) 5922 0.02725 2.84 up Mm.30370 Xtrp2 97465_at AF075267 X transporter protein 2923 0.02727 1.78 down Mm.28848 AI182287 94469_at AW120950 expressed sequence AI182287924 0.02728 1.48 down Mm.203930 AI035702 102003_at AI842159 expressed sequence AI035702925 0.02737 1.76 down Mm.196142 Dnajc7 160153_at AI835917 DnaJ (Hsp40) homolog, subfamily C, member 7926 0.02738 2.21 down Mm.6221 Capn1 100932_at AF084459 calpain 1927 0.02739 1.54 down Mm.29845 Suclg1 96268_at AI840979 succinate-CoA ligase, GDP-forming, alpha subunit928 0.02739 3.44 up Mm.30083 2510015F01Rik 96885_at AW122271 RIKEN cDNA 2510015F01 gene929 0.02743 3.32 up Mm.6217 Kcns1 101624_at AF008573 K+ voltage-gated channel, subfamily S, 1930 0.02744 1.36 down Mm.154570 Erp29 98076_at AI835644 endoplasmic reticulum protein 29931 0.02758 1.37 down Mm.24231 Smap-pending 95411_at AB025407 small acidic protein932 0.02763 1.52 up Mm.6523 S100a13 100960_g_at X99921 S100 calcium binding protein A13933 0.02765 1.55 down Mm.45155 1810059G22Rik 160497_at AW060728 RIKEN cDNA 1810059G22 gene934 0.02769 1.52 down Mm.154580 9430059D04Rik 99592_f_at AB030505 RIKEN cDNA 9430059D04 gene935 0.02771 1.77 up Mm.27649 4930588A18Rik 162489_i_at AV138018 RIKEN cDNA 4930588A18 gene936 0.02772 2.63 up Mm.200936 Lnk 93939_at U89993 linker of T-cell receptor pathways937 0.02773 4.43 up Mm.218770 Ifi202a 94774_at M31418 interferon activated gene 202A938 0.02778 2.93 up Mm.34953 Slc25a14 98470_at AF076981 solute carrier family 25 (mitochondrial carrier, brain), member 14939 0.02778 2.17 up Mm.200907 Slc25a15 104007_at AA986782 solute carrier family 25 (mitochondrial carrier; ornithine transporter), member940 0.02784 3.39 up Mm.21882 Cd84 94027_at AA815831 CD84 antigen941 0.02785 2.12 up Mm.20415 1110031C13Rik 103651_r_at AI841186 RIKEN cDNA 1110031C13 gene942 0.02786 1.42 down Mm.43482 D6Wsu147e 99635_at AI845183 DNA segment, Chr 6, Wayne State University 147, expressed943 0.02804 1.91 down Mm.205421 D14Ertd453e 104419_at AI132380 DNA segment, Chr 14, ERATO Doi 453, expressed944 0.02809 3.33 up Mm.19943 Prg3 95300_at AI326147 proteoglycan 3945 0.02812 3.43 up Mm.4910 Evx1 98816_s_at AW049988 even skipped homeotic gene 1 homolog946 0.02818 1.75 down Mm.203947 AU040868 103899_at AA690863 expressed sequence AU040868947 0.02834 2.02 down Mm.29772 Nagk 97385_at AJ242909 N-acetylglucosamine kinase948 0.02837 1.97 down Mm.10699 Vamp4 102317_at AF061516 vesicle-associated membrane protein 4949 0.02843 2.05 up Mm.14838 Rpl44 160081_at AW045418 ribosomal protein L44950 0.02846 1.99 up Mm.29356 C80758 160336_at AI850692 expressed sequence C80758951 0.02846 2.52 up Mm.409 Mm.409 102160_at X87638 Mouse intracisternal A-particle-related retroviral elements and envelope pseu952 0.02849 2.67 up Mm.19945 Mmp14 160118_at AF022432 matrix metalloproteinase 14 (membrane-inserted)953 0.02855 2.19 down Mm.205997 AI481106 92941_at AA833509 expressed sequence AI481106954 0.02863 3.48 up Mm.18422 AI462243 103355_at AI120671 expressed sequence AI462243955 0.02864 2.34 up Mm.40615 Kcnq2 99450_at AB000503 potassium voltage-gated channel, subfamily Q, member 2956 0.02866 2.23 up Mm.2144 Evl 161808_f_at AV371846 Ena-vasodilator stimulated phosphoprotein957 0.02875 2.16 up Mm.12968 Chst2 102639_at AB011451 carbohydrate sulfotransferase 2958 0.02879 2.00 down Mm.14719 Gsta3 93015_at X65021 glutathione S-transferase, alpha 3959 0.02879 2.45 up Mm.2758 Mkrn3 96704_at AF058798 makorin, ring finger protein, 3960 0.02879 2.30 up Mm.197519 5031415C07Rik 103517_at AA822898 RIKEN cDNA 5031415C07 gene961 0.02880 1.96 up Mm.30011 Rps23 96358_at AI837403 ribosomal protein S23962 0.02886 1.73 up Mm.28438 Plunc 97900_at AI845714 palate, lung, and nasal epithelium expressed transcript963 0.02890 1.86 up Mm.29491 Mm.29491 95641_at AI853899 ESTs964 0.02895 1.57 down Mm.195451 Gosr2 94071_at AI847904 golgi SNAP receptor complex member 2965 0.02896 2.85 down Mm.12286 Alox12 102290_at U04334 arachidonate 12-lipoxygenase966 0.02897 1.89 down Mm.19006 AL024210 103429_i_at AW125330 expressed sequence AL024210967 0.02897 1.98 up Mm.28379 Nup50 93047_at AI849144 nucleoprotein 50968 0.02903 5.24 up Mm.180499 2610029G23Rik 161520_at AV217463 RIKEN cDNA 2610029G23 gene969 0.02909 1.46 down Mm.27657 Sssca1 96718_at AB012727 Sjogren's syndrome/scleroderma autoantigen 1 homolog (human)970 0.02912 1.58 down Mm.3074 Ube2l3 97479_at AJ130961 ubiquitin-conjugating enzyme E2L 3971 0.02914 1.80 down Mm.3840 Flot2 99007_at U07890 flotillin 2972 0.02914 1.99 down Mm.196031 Nfkbib 99982_at U19799 nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta973 0.02915 4.31 up 100001_at M18228974 0.02930 1.58 down Mm.45146 Pphn 96019_at AI843476 pantophysin975 0.02931 1.64 up Mm.7049 AI413331 93472_at AA796989 expressed sequence AI413331976 0.02934 1.56 down Mm.13705 Rrbp1 92850_at AI836446 ribosome binding protein 1977 0.02936 1.53 down Mm.181278 4921505F14Rik 96002_at AW123936 RIKEN cDNA 4921505F14 gene978 0.02958 1.90 down Mm.4082 Emk 99458_i_at X70764 ELKL motif kinase979 0.02958 3.31 up Mm.204646 Mm.204646 161511_f_at AV152244 Mus musculus adult male hippocampus cDNA, RIKEN full-length enriched lib980 0.02967 2.17 up Mm.644 Mef2b 93417_at D50311 myocyte enhancer factor 2B981 0.02974 5.87 up Mm.29499 Cpt2 161978_r_at AV372996 carnitine palmitoyltransferase 2982 0.02974 1.75 down Mm.196449 Rnp24-pending 93818_g_at AB025218 coated vesicle membrane protein983 0.02976 1.98 down Mm.26944 1700057K18Rik 161631_f_at AV046503 RIKEN cDNA 1700057K18 gene984 0.02977 1.81 up Mm.29390 2400007P05Rik 95121_at AW060791 RIKEN cDNA 2400007P05 gene985 0.02981 2.64 up Mm.2470 2610201A13Rik 161134_at AV298639 RIKEN cDNA 2610201A13 gene986 0.02984 3.37 up 95184_f_at AA419684987 0.02985 2.19 down Mm.30435 Tsc2 97953_g_at U39818 tuberous sclerosis 2988 0.02986 2.26 up Mm.16332 Efna4 103041_at U92890 ephrin A4989 0.02987 2.44 up Mm.12897 Gp9 102311_at AB007464 glycoprotein 9 (platelet)990 0.02988 1.64 down Mm.203878 AI449174 103251_at AW125822 expressed sequence AI449174Page 11 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description991 0.02993 3.99 up Mm.1902 AI225904 103200_at AA711773 expressed sequence AI225904992 0.03006 1.59 up Mm.200920 Rps28 98085_f_at U11248 ribosomal protein S28993 0.03015 1.90 down Mm.1040 2610511I23Rik 102232_at AI850740 RIKEN cDNA 2610511I23 gene994 0.03016 2.10 up Mm.213458 Mm.213458 93224_at M31649 Mouse T-cell receptor rearranged alpha-chain mRNA V-J-C region, 3' end995 0.03020 1.44 up Mm.218848 3010002G01Rik 99179_at AI846233 RIKEN cDNA 3010002G01 gene996 0.03030 1.54 down Mm.27502 D16H22S680E 95025_at X74504 DNA segment, Chr 16, human D22S680E, expressed997 0.03032 2.25 down Mm.30041 AU040324 96854_at AJ010391 expressed sequence AU040324998 0.03033 3.22 up Mm.7973 Ids 99882_at L07921 iduronate 2-sulfatase999 0.03038 5.07 up Mm.196055 D6Ertd439e 95354_at AI605585 DNA segment, Chr 6, ERATO Doi 439, expressed1000 0.03042 1.29 up Mm.87776 H2-T10 93865_s_at M35244 histocompatibility 2, T region locus 101001 0.03044 5.62 up Mm.1736 Chl1 103088_at X94310 close homolog of L11002 0.03047 3.83 up Mm.154039 Atp4b 100501_at M80251 ATPase, H+/K+ transporting, beta polypeptide, gastric specific1003 0.03051 6.69 up Mm.392 Indo 161824_r_at AV381044 indoleamine-pyrrole 2,3 dioxygenase1004 0.03053 1.99 down Mm.25044 Fliih 97594_r_at C79694 flightless I homolog (Drosophila)1005 0.03059 2.68 down Mm.12616 Dnajc3 102415_r_at U28423 DnaJ (Hsp40) homolog, subfamily C, member 31006 0.03066 2.30 up Mm.18814 1300006M19Rik 103409_at AA656550 RIKEN cDNA 1300006M19 gene1007 0.03067 1.89 up Mm.3401 Pcsk5 92193_r_at D12619 proprotein convertase subtilisin/kexin type 51008 0.03070 1.94 down Mm.3526 Ank3 98477_s_at L40632 ankyrin 3, epithelial1009 0.03073 1.99 down Mm.28150 Sf3b1 97808_at AI844532 splicing factor 3b, subunit 1, 155 kDa1010 0.03082 1.72 down Mm.21824 2810449C13Rik 104092_at AW124926 RIKEN cDNA 2810449C13 gene1011 0.03086 1.56 up Mm.197437 2810008P14Rik 104150_at AW121957 RIKEN cDNA 2810008P14 gene1012 0.03096 1.49 down Mm.12887 Tulp3 102308_at AF045582 tubby-like protein 31013 0.03099 2.03 up Mm.28073 D11Ertd172e 161441_f_at AV350341 DNA segment, Chr 11, ERATO Doi 172, expressed1014 0.03108 1.88 up Mm.702 Rps16 97647_at M11408 ribosomal protein S161015 0.03110 2.27 up Mm.5725 Mm.5725 101233_at C78616 ESTs1016 0.03114 3.51 up Mm.41456 Pcp2 102376_r_at M21532 Purkinje cell protein 2 (L7)1017 0.03114 1.37 up Mm.29503 1110007B08Rik 95649_at AI844440 RIKEN cDNA 1110007B08 gene1018 0.03123 2.06 up Mm.6159 Mm.6159 101615_at AA673515 EST1019 0.03125 3.58 up Mm.28362 AI326478 102158_at K02138 expressed sequence AI3264781020 0.03126 1.64 up Mm.212712 Iap 101787_f_at X16672 intracisternal A particles1021 0.03126 2.55 up Mm.203895 AW124766 162095_f_at AV341518 expressed sequence AW1247661022 0.03130 1.78 down Mm.202871 1190005L06Rik 102883_at AW107702 RIKEN cDNA 1190005L06 gene1023 0.03134 3.42 up Mm.4155 Ros1 97765_g_at U15443 Ros1 proto-oncogene1024 0.03139 1.75 up Mm.4708 Syk 100425_at U25685 spleen tyrosine kinase1025 0.03146 1.76 up Mm.8771 Pip5k2a 95358_at AI843864 phosphatidylinositol-4-phosphate 5-kinase, type II, alpha1026 0.03154 2.15 up Mm.3730 Sema3e 92295_at Z80941 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (se1027 0.03154 1.56 down Mm.30206 Atp6m 96951_at AI839795 ATPase, H+ transporting lysosomal (vacuolar proton pump)1028 0.03173 2.15 up Mm.87835 V2r12 101352_g_at AF022251 vomeronasal 2, receptor, 121029 0.03173 2.65 up Mm.14768 Rex3 93021_at AA790008 reduced expression 31030 0.03198 3.12 down Mm.200499 Eif2ak1 93737_at AF028808 eukaryotic translation initiation factor 2 alpha kinase 11031 0.03199 2.19 up Mm.147693 Rps3 101137_at X76772 ribosomal protein S31032 0.03206 2.13 down Mm.46513 2610200G18Rik 104229_at AI840035 RIKEN cDNA 2610200G18 gene1033 0.03214 5.72 up Mm.22451 Khk 104323_at Y09335 ketohexokinase1034 0.03222 1.64 down Mm.17 Bcap31 93252_at X81816 B-cell receptor-associated protein 311035 0.03225 1.64 up Mm.262 Arhc 96056_at X80638 ras homolog 9 (RhoC)1036 0.03229 2.88 up Mm.4708 Syk 100426_s_at U36776 spleen tyrosine kinase1037 0.03235 1.57 up Mm.24788 Mm.24788 104756_at AA739415 ESTs1038 0.03242 2.04 up Mm.29363 2310044F10Rik 95109_at AW121447 RIKEN cDNA 2310044F10 gene1039 0.03250 2.38 up Mm.4799 Gcet 101147_at U13263 germinal center expressed transcript1040 0.03254 1.48 down Mm.7138 Plrg1 101064_at AF044334 pleiotropic regulator 1, PRL1 homolog (Arabidopsis)1041 0.03260 1.51 down Mm.7729 Aldo3 160546_at AW121134 aldolase 3, C isoform1042 0.03260 2.13 up Mm.34330 Blcap 98055_at AW121500 bladder cancer associated protein homolog (human)1043 0.03268 1.82 down Mm.27585 AA407270 161001_at AV367683 expressed sequence AA4072701044 0.03268 3.49 up Mm.26688 Thbs2 94930_at L07803 thrombospondin 21045 0.03269 2.01 up Mm.78093 AV308913 101443_at AI846119 expressed sequence AV3089131046 0.03272 2.85 up Mm.25056 C79741 95992_at C79950 expressed sequence C797411047 0.03279 1.63 down Mm.6560 2810403H05Rik 100963_at AI854243 RIKEN cDNA 2810403H05 gene1048 0.03283 1.43 down Mm.12468 Gbas 102402_at AJ001261 glioblastoma amplified sequence1049 0.03288 1.63 up Mm.34589 Rpo1-2 92225_f_at U58280 RNA polymerase 1-2 (128 kDa subunit)1050 0.03291 1.73 down Mm.10800 Kcnk1 102335_at AF033017 potassium channel, subfamily K, member 11051 0.03297 1.79 down Mm.4079 2300007F24Rik 92398_at AI848723 RIKEN cDNA 2300007F24 gene1052 0.03303 1.69 down Mm.28765 1810049E02Rik 98956_at AI844979 RIKEN cDNA 1810049E02 gene1053 0.03310 2.05 down Mm.28922 Farsl 94494_at AI840856 phenylalanine-tRNA synthetase-like1054 0.03317 2.72 down Mm.27432 Dnajb9 96680_at AI835630 DnaJ (Hsp40) homolog, subfamily B, member 91055 0.03322 1.98 up Mm.7992 Cnr1 99892_at U17985 cannabinoid receptor 1 (brain)1056 0.03333 5.06 up Mm.918 Hspa5 162445_at AV351546 heat shock 70kD protein 5 (glucose-regulated protein, 78kD)1057 0.03338 2.11 up Mm.87801 Pira3 100328_s_at U96684 paired-Ig-like receptor A31058 0.03339 1.89 up Mm.30200 0610009I16Rik 162144_at AV351508 RIKEN cDNA 0610009I16 gene1059 0.03343 2.50 up Mm.6756 Mtr 101660_at AA415486 5-methyltetrahydrofolate-homocysteine methyltransferase1060 0.03364 3.16 up Mm.5674 C78067 101228_at C78067 expressed sequence C780671061 0.03365 1.87 down Mm.30729 1110002O23Rik 97964_at AW122851 RIKEN cDNA 1110002O23 gene1062 0.03371 2.49 up Mm.3233 Irf7 162202_f_at AV373853 interferon regulatory factor 71063 0.03374 3.40 up Mm.20271 Fbn2 103623_at L39790 fibrillin 21064 0.03380 2.41 down Mm.16497 Tcf21 103050_at AF035717 transcription factor 211065 0.03386 1.44 down Mm.12677 Atp5c1 92799_g_at AA870675 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypepti1066 0.03395 2.03 up Mm.5 Hoxa10 92970_at L08757 homeo box A101067 0.03395 4.38 up Mm.43005 Uba52 95907_at AW124972 ubiquitin A-52 residue ribosomal protein fusion product 11068 0.03397 1.86 down Mm.1266 Prkca 102299_at M25811 protein kinase C, alpha1069 0.03408 2.75 up Mm.21414 Ccsd 162351_f_at AV174603 copper chaperone for superoxide dismutase1070 0.03421 1.37 down Mm.21451 4933434E20Rik 102141_f_at AI462340 RIKEN cDNA 4933434E20 gene1071 0.03428 2.55 down Mm.24261 AI848335 160970_at AI848335 expressed sequence AI8483351072 0.03432 5.77 up Mm.20285 Krt2-19 161175_r_at AV241614 keratin complex 2, basic, gene 191073 0.03432 1.39 up Mm.34708 2610019N19Rik 98096_f_at AI840219 RIKEN cDNA 2610019N19 gene1074 0.03432 5.21 up Mm.1160 AI597080 161541_r_at AV239332 expressed sequence AI5970801075 0.03447 3.03 up Mm.141741 Clp-pending 95466_at AI837006 coactosin-like protein1076 0.03448 3.15 up Mm.116700 Crlf1 161046_at AA270365 cytokine receptor-like factor 11077 0.03451 2.15 up Mm.25888 1700003F10Rik 160214_at AW122235 RIKEN cDNA 1700003F10 gene1078 0.03453 2.32 down Mm.25293 Pcmt1 94347_i_at AW124044 protein-L-isoaspartate (D-aspartate) O-methyltransferase 11079 0.03459 1.92 down Mm.193096 Scd2 95758_at M26270 stearoyl-Coenzyme A desaturase 21080 0.03461 6.04 up Mm.6863 C80129 93458_at AA501129 expressed sequence C80129Page 12 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description1081 0.03468 2.32 up Mm.10205 Utf1 102220_at AB017360 undifferentiated embryonic cell transcription factor 11082 0.03469 2.06 down Mm.7880 Amd1 101489_at D12780 S-adenosylmethionine decarboxylase 11083 0.03470 2.23 down Mm.4471 1810041M12Rik 99988_at AW122115 RIKEN cDNA 1810041M12 gene1084 0.03476 1.77 up Mm.57170 Gdf11 101814_at AF100906 growth differentiation factor 111085 0.03479 1.53 down Mm.123240 1700016D08Rik 162350_at AV173777 RIKEN cDNA 1700016D08 gene1086 0.03480 2.55 up Mm.4219 Man2b1 162150_r_at AV327201 mannosidase 2, alpha B11087 0.03489 1.51 down Mm.20946 Psmc3 93734_i_at D49686 proteasome (prosome, macropain) 26S subunit, ATPase 31088 0.03498 3.02 up Mm.2699 Igsf7 104023_at AW060457 immunoglobulin superfamily, member 71089 0.03499 1.39 up Mm.28203 2410130M07Rik 97824_at AW121031 RIKEN cDNA 2410130M07 gene1090 0.03506 1.59 down Mm.10093 1110007A04Rik 102022_at AW124555 RIKEN cDNA 1110007A04 gene1091 0.03507 3.97 up Mm.1412 Dspp 94721_at AJ002141 dentin sialophosphoprotein1092 0.03507 2.08 up Mm.205258 D17892 100347_at AA154606 expressed sequence D178921093 0.03509 1.67 down Mm.19130 1110059L23Rik 93496_at AI852098 RIKEN cDNA 1110059L23 gene1094 0.03516 3.26 up Mm.135114 AA408225 104083_at AI853217 expressed sequence AA4082251095 0.03524 1.71 up Mm.565 Sptlc2 100893_at U27455 serine palmitoyltransferase, long chain base subunit 21096 0.03524 1.58 up Mm.25732 1200014H24Rik 96027_at AW120546 RIKEN cDNA 1200014H24 gene1097 0.03527 1.80 down Mm.3996 Chuk 99070_at U12473 conserved helix-loop-helix ubiquitous kinase1098 0.03533 1.93 down Mm.195923 3110001K11Rik 97579_f_at AJ224343 RIKEN cDNA 3110001K11 gene1099 0.03535 3.96 down Mm.25122 AA408985 94343_at AI604013 expressed sequence AA4089851100 0.03535 3.31 up Mm.177725 Arf3 96587_at D87900 ADP-ribosylation factor 31101 0.03536 1.90 down Mm.22363 Mm.22363 104305_at AW120679 Mus musculus, similar to Unknown (protein for MGC:14993), clone MGC:2821102 0.03549 2.74 up Mm.20842 Cdc7l1 103797_at AB019388 cell division cycle 71 homolog (S. cerevisiae)-like 11103 0.03551 2.35 down Mm.14114 Ceacam1 102804_at X67279 CEA-related cell adhesion molecule 11104 0.03552 1.49 down Mm.29182 Taldo1 95066_at U67611 transaldolase 11105 0.03563 1.58 down Mm.89927 Srp9 101579_at X78304 signal recognition particle 9 kDa1106 0.03567 1.79 down Mm.10682 Capn5 102316_at Y10656 calpain 51107 0.03571 2.90 down Mm.36850 Smtn 98559_at AJ010305 smoothelin1108 0.03581 6.81 up Mm.3862 Igf2 98623_g_at X71922 insulin-like growth factor 21109 0.03590 2.00 up Mm.3834 Cnlp 92322_at X94353 cathelin-like protein1110 0.03594 2.87 up Mm.39469 Tnni2 93532_at J04992 troponin I, skeletal, fast 21111 0.03600 1.71 down Mm.3545 Ica1 98484_at U37186 islet cell autoantigen 1, 69 kDa1112 0.03611 7.46 up Mm.6853 Sprr2a 101024_i_at AJ005559 small proline-rich protein 2A1113 0.03612 1.63 down Mm.196604 Aamp-rs 98064_at AW125378 angio-associated migratory protein, related sequence1114 0.03614 1.88 down Mm.16519 Nr2f2 103052_r_at X76653 nuclear receptor subfamily 2, group F, member 21115 0.03633 2.86 down Mm.14601 Gstm2 93009_at J04696 glutathione S-transferase, mu 21116 0.03634 2.01 down Mm.25608 1110057K04Rik 94382_at AI851901 RIKEN cDNA 1110057K04 gene1117 0.03649 2.93 up Mm.2253 Klkb1 104344_at M58588 kallikrein B, plasma 11118 0.03653 2.24 down Mm.218793 Xlr3b 101883_s_at L22977 X-linked lymphocyte-regulated 3b1119 0.03656 2.23 up Mm.6258 Eda 93393_at AF016628 ectodysplasin-A1120 0.03661 1.75 up Mm.2548 U90926 100717_at U90926 cDNA sequence U909261121 0.03662 3.61 up Mm.18628 Cd36 161704_r_at AV091761 CD36 antigen1122 0.03669 3.92 up Mm.195048 Defcr6 93863_f_at U03003 defensin related cryptdin 61123 0.03670 4.10 up Mm.2999 Fin16 97421_at U42385 fibroblast growth factor inducible 161124 0.03671 2.00 up Mm.6221 Capn1 161423_r_at AV294809 calpain 11125 0.03672 2.78 up Mm.197478 Imap38 161384_r_at AV250661 immunity-associated protein, 38 kDa1126 0.03675 1.31 up Mm.172945 2610028J07Rik 98369_f_at AW048053 RIKEN cDNA 2610028J07 gene1127 0.03676 1.49 up Mm.29824 Psa 162440_r_at AV347344 puromycin-sensitive aminopeptidase1128 0.03686 1.77 down Mm.28668 Cope 98930_at AI844701 coatomer protein complex, subunit epsilon1129 0.03694 2.07 up Mm.24517 1110029L11Rik 161220_f_at AV252802 RIKEN cDNA 1110029L11 gene1130 0.03697 2.22 up Mm.42192 Kip2-pending 99536_at AB016080 kinase interacting protein 21131 0.03699 2.33 up Mm.1 S100a10 162340_r_at AV128077 S100 calcium binding protein A10 (calpactin)1132 0.03705 1.73 down Mm.196484 Csrp 92608_at D88793 cysteine rich protein1133 0.03706 2.68 up Mm.14126 Mmp10 94724_at Y13185 matrix metalloproteinase 101134 0.03706 1.42 down Mm.18353 Dpagt2 103352_at X65603 dolichyl-phosphate alpha-N-acetylglucosaminephosphotransferase 21135 0.03710 2.19 up Mm.34483 Mm.34483 103326_at AI852663 ESTs, Weakly similar to C52B9.3.p [Caenorhabditis elegans] [C.elegans]1136 0.03718 1.61 up Mm.141587 Csda 95755_at D14485 cold shock domain protein A1137 0.03730 1.50 down Mm.1605 Pdcd4 103029_at D86344 programmed cell death 41138 0.03737 1.73 down Mm.19091 AU042646 103557_at AI850046 expressed sequence AU0426461139 0.03745 1.68 up Mm.361 Ptpn18 92273_at U49853 protein tyrosine phosphatase, non-receptor type 181140 0.03756 1.64 up Mm.925 Tfdp1 101959_r_at X72310 transcription factor Dp 11141 0.03758 1.39 down Mm.23723 AI573938 103547_at AI837116 expressed sequence AI5739381142 0.03762 1.63 up Mm.4046 Ms4a2 104173_at AA797989 membrane-spanning 4-domains, subfamily A, member 21143 0.03764 2.10 down Mm.2875 1100001J13Rik 98951_at AI843258 RIKEN cDNA 1100001J13 gene1144 0.03769 2.88 up Mm.1514 Lpl 95611_at AA726364 lipoprotein lipase1145 0.03773 1.64 down Mm.7838 Maid 101483_at AI850862 maternal inhibition of differentiation1146 0.03778 2.83 up Mm.22662 Krt1-10 162121_at AV374020 keratin complex 1, acidic, gene 101147 0.03779 3.47 up Mm.2561 Esr2 96514_at U81451 estrogen receptor 2 (beta)1148 0.03780 5.82 up Mm.1461 Sell 102838_at M36058 selectin, lymphocyte1149 0.03789 6.00 up Mm.9257 D10Wsu52e 161197_r_at AV255941 DNA segment, Chr 10, Wayne State University 52, expressed1150 0.03795 3.73 up Mm.14438 AU044919 102824_g_at X67210 expressed sequence AU0449191151 0.03802 2.12 up Mm.24615 Gja4 104729_at X57971 gap junction membrane channel protein alpha 41152 0.03804 2.13 down Mm.8108 Wee1 101458_at D30743 wee 1 homolog (S. pombe)1153 0.03817 1.45 down Mm.22276 AW495282 104288_at AI853265 expressed sequence AW4952821154 0.03818 1.73 up Mm.200373 Sgpl1 96126_at AF036894 sphingosine phosphate lyase 11155 0.03820 3.82 up Mm.30250 D18Wsu181e 161783_at AV362606 DNA segment, Chr 18, Wayne State University 181, expressed1156 0.03822 1.91 down Mm.39040 Mal 99089_at Y07812 myelin and lymphocyte protein, T-cell differentiation protein1157 0.03822 4.02 up Mm.13211 Mm.13211 94685_at C76510 ESTs1158 0.03826 1.41 up Mm.8575 Sox13 93698_at AB006329 SRY-box containing gene 131159 0.03844 2.04 up Mm.29279 Smoh 96812_at AF089721 smoothened homolog (Drosophila)1160 0.03846 2.06 up Mm.27291 Bysl 160227_s_at AI132491 bystin-like1161 0.03846 1.75 up Mm.24035 D16Ertd480e 103701_at AA420331 DNA segment, Chr 16, ERATO Doi 480, expressed1162 0.03854 3.31 up Mm.1643 AW413625 161142_at AV204395 expressed sequence AW4136251163 0.03856 3.75 up Mm.4669 Adam2 92732_at U16242 a disintegrin and metalloprotease domain 21164 0.03860 1.86 up Mm.200540 R74921 102312_r_at AW046728 expressed sequence R749211165 0.03861 4.03 up Mm.108242 Dnahc8 95309_at AA789879 dynein, axon, heavy chain 81166 0.03861 1.57 down Mm.29426 Sfrs9 96834_at AI843586 splicing factor, arginine/serine rich 9 (25 kDa)1167 0.03875 10.13 up Mm.34545 Mm.34545 97129_at AA617494 ESTs, Weakly similar to I49636 DNA-binding protein - mouse [M.musculus]1168 0.03887 1.81 down Mm.26422 Copg1 94427_at AI841737 coatomer protein complex, subunit gamma 11169 0.03891 1.87 up Mm.37215 Siah1b 92290_at Z19580 seven in absentia 1B1170 0.03894 5.51 up Mm.788 Ly6e 161299_r_at AV049751 lymphocyte antigen 6 complex, locus EPage 13 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description1171 0.03904 1.91 down Mm.88704 Ppp1r7 97979_at AI849126 protein phosphatase 1, regulatory (inhibitor) subunit 71172 0.03910 1.36 down Mm.35698 Prei2 98146_at AW120775 preimplantation protein 21173 0.03910 2.58 up Mm.141702 Myoz1 104555_at AA733946 myozenin 11174 0.03914 1.56 down Mm.28017 Fbxw1b 160764_at AW046376 F-box and WD-40 domain protein 1B1175 0.03915 4.60 up Mm.196085 Igh-4 97720_at AF000913 immunoglobulin heavy chain 4 (serum IgG1)1176 0.03916 2.89 up Mm.22574 Csf1r 104354_at X06368 colony stimulating factor 1 receptor1177 0.03916 2.89 up Mm.198 Mm.198 160642_at AI853079 Mus musculus, Similar to transmembrane protein 5, clone MGC:28135 IMAG1178 0.03917 1.26 down Mm.7463 Mm.7463 93627_at AI852287 ESTs1179 0.03924 1.69 down Mm.42855 1110030G05Rik 99599_s_at AW210320 RIKEN cDNA 1110030G05 gene1180 0.03925 1.47 down Mm.3874 Adh5 98625_s_at M84147 alcohol dehydrogenase 51181 0.03930 1.56 up Mm.3295 Bok 98031_at AF027707 Bcl-2-related ovarian killer protein1182 0.03931 1.99 down Mm.7308 Smarcd1 101405_at M25773 SWI/SNF related, matrix associated, actin dependent regulator of chromatin,1183 0.03932 3.04 up Mm.23999 Mm.23999 95887_at AI451008 ESTs1184 0.03935 3.02 up Mm.6018 AA675346 93245_at AI645718 expressed sequence AA6753461185 0.03939 2.17 down Mm.176927 2610301I15Rik 94010_g_at AI848888 RIKEN cDNA 2610301I15 gene1186 0.03942 1.95 up Mm.181860 2310057H16Rik 160461_f_at AW215736 RIKEN cDNA 2310057H16 gene1187 0.03943 1.90 up Mm.5291 Rps5 99336_at U78085 ribosomal protein S51188 0.03946 1.54 down Mm.24875 Mrps18a 94327_at AW230209 mitochondrial ribosomal protein S18A1189 0.03959 2.47 up Mm.7386 Mfap2 101095_at L23769 microfibrillar-associated protein 21190 0.03968 1.59 up Mm.143755 Brd4 104352_at AI838366 bromodomain-containing 41191 0.03977 1.97 down Mm.29382 1110038D17Rik 161534_f_at AV234294 RIKEN cDNA 1110038D17 gene1192 0.04004 1.38 up Mm.23910 Etohd2 104572_at AI852047 ethanol decreased 21193 0.04007 1.47 down Mm.27476 Mm.27476 95021_at AW124028 ESTs, Highly similar to hypothetical protein FLJ10154 [Homo sapiens] [H.sa1194 0.04014 1.80 down Mm.30250 D18Wsu181e 97450_s_at AA986258 DNA segment, Chr 18, Wayne State University 181, expressed1195 0.04015 1.92 up Mm.21569 2700069E09Rik 96843_at AF068116 RIKEN cDNA 2700069E09 gene1196 0.04018 1.49 up Mm.1896 AW536594 102980_at AI849119 expressed sequence AW5365941197 0.04022 2.62 up Mm.13351 Mm.13351 99756_at C81515 ESTs1198 0.04028 11.47 up Mm.28057 1110064N10Rik 161746_i_at AV320590 RIKEN cDNA 1110064N10 gene1199 0.04031 2.03 down Mm.12616 Dnajc3 102414_i_at U28423 DnaJ (Hsp40) homolog, subfamily C, member 31200 0.04037 2.21 up Mm.2720 Mapk8ip 161619_f_at AV354894 mitogen activated protein kinase 8 interacting protein1201 0.04040 3.79 up Mm.2021 AI788959 103227_at AI788959 expressed sequence AI7889591202 0.04043 1.69 down Mm.28287 AU015605 97853_at AW047331 expressed sequence AU0156051203 0.04044 4.91 up Mm.5330 Olr1 93167_f_at AA104818 oxidised low density lipoprotein (lectin-like) receptor 11204 0.04047 4.65 up Mm.272 Spink3 96630_at X06342 serine protease inhibitor, Kazal type 31205 0.04047 1.96 down Mm.30051 Rnf10 96859_at AB026621 ring finger protein 101206 0.04052 2.22 up Mm.196637 1200003I10Rik 161124_at AV237354 RIKEN cDNA 1200003I10 gene1207 0.04060 3.05 down 93573_at V008351208 0.04062 1.46 down Mm.27839 4930455J02Rik 97240_g_at AI845106 RIKEN cDNA 4930455J02 gene1209 0.04066 1.34 up Mm.29586 Basp1 95674_r_at AI851985 brain abundant, membrane attached signal protein 11210 0.04069 3.83 up Mm.218310 Mm.218310 160934_s_at X05546 Murine (DBA/2) mRNA fragment for gag related peptide1211 0.04070 3.98 up Mm.28480 Fkbp3 161795_r_at AV366904 FK506 binding protein 3 (25kD)1212 0.04073 1.58 down Mm.163 B2m 93088_at X01838 beta-2 microglobulin1213 0.04074 1.91 up Mm.28275 Rbmx 97848_at AJ237846 RNA binding motif protein, X chromosome1214 0.04079 2.47 up Mm.16861 C78142 94782_at C78137 expressed sequence C781421215 0.04087 2.40 up Mm.25086 C80731 103927_at AW212672 expressed sequence C807311216 0.04092 2.24 up Mm.3869 Prrx1 99021_at U03873 paired related homeobox 11217 0.04106 1.71 down Mm.103551 Tollip-pending 160809_at AI842752 toll interacting protein1218 0.04108 2.35 up Mm.196591 Spi1-3 101565_f_at M75720 serine protease inhibitor 1-31219 0.04112 2.06 down Mm.24006 1110013O05Rik 162428_i_at AV293396 RIKEN cDNA 1110013O05 gene1220 0.04116 5.17 up Mm.2068 Ncf4 103662_at U59488 neutrophil cytosolic factor 41221 0.04117 1.78 up Mm.3711 Gdm1 98984_f_at D50430 glycerol phosphate dehydrogenase 1, mitochondrial1222 0.04119 1.55 down Mm.4294 Adcy9 92527_at Z50190 adenylate cyclase 91223 0.04122 1.76 down Mm.2559 Umpk 94381_at L31783 uridine monophosphate kinase1224 0.04125 1.57 down Mm.2261 Psmd4 94302_at AF013099 proteasome (prosome, macropain) 26S subunit, non-ATPase, 41225 0.04127 13.57 up Mm.30438 Tyrp1 161538_r_at AV237026 tyrosinase-related protein 11226 0.04132 4.03 up Mm.17484 Snca 93273_at AF044672 synuclein, alpha1227 0.04134 1.84 up Mm.10303 Nol5 92569_f_at AF053232 nucleolar protein 51228 0.04136 1.90 up Mm.28040 1500036F01Rik 160264_s_at AI836143 RIKEN cDNA 1500036F01 gene1229 0.04136 2.06 down Mm.205791 Atp1a1 93797_g_at AW123952 ATPase, Na+/K+ transporting, alpha 1 polypeptide1230 0.04139 1.65 up Mm.196189 Angptl4 96119_s_at AA797604 angiopoietin-like 41231 0.04144 3.34 up Mm.9821 Sah 102192_r_at AF068246 SA rat hypertension-associated homolog1232 0.04147 2.87 up Mm.143603 Sh3d2a 92673_at U58886 SH3 domain protein 2A1233 0.04156 2.68 up Mm.10374 2610002J02Rik 102057_r_at AA839379 RIKEN cDNA 2610002J02 gene1234 0.04163 1.45 down Mm.28580 Mtm1 96199_at AF073996 X-linked myotubular myopathy gene 11235 0.04169 1.34 down Mm.235 Ubb 101255_at X51703 ubiquitin B1236 0.04171 1.81 down Mm.27843 Mm.27843 104215_at AA592069 ESTs1237 0.04174 2.03 down Mm.46719 4933432H23Rik 160959_at AA597220 RIKEN cDNA 4933432H23 gene1238 0.04177 1.40 up Mm.4609 Pex14 100029_at AW208667 peroxisomal biogenesis factor 141239 0.04177 1.81 down Mm.203924 AW259572 92348_at AI841022 expressed sequence AW2595721240 0.04187 2.06 up Mm.5080 Sox17 92996_at D49473 SRY-box containing gene 171241 0.04192 2.86 up Mm.2375 Ckmm 161569_f_at AV086797 creatine kinase, muscle1242 0.04193 3.09 up Mm.6523 S100a13 161121_f_at AV007820 S100 calcium binding protein A131243 0.04194 2.30 down Mm.7892 Rfx1 99880_at X76088 regulatory factor (trans-acting) 11244 0.04202 1.51 up Mm.21772 Smarcd2 161077_f_at AV252495 SWI/SNF related, matrix associated, actin dependent regulator of chromatin,1245 0.04209 1.58 down Mm.4730 Ppox 100429_at U89155 protoporphyrinogen oxidase1246 0.04215 2.35 down Mm.41625 Sirt3 160869_at AI849490 sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisia1247 0.04219 1.69 down Mm.2389 Mll 104569_at AW122024 myeloid/lymphoid or mixed-lineage leukemia1248 0.04227 1.77 down Mm.22338 Mm.22338 104299_at AI842472 Mus musculus, Similar to hypothetical protein FLJ20984, clone MGC:291941249 0.04239 3.35 down Mm.18502 Osbpl1a 93316_at AB017026 oxysterol binding protein-like 1A1250 0.04243 2.52 up Mm.214491 Pld1 92474_at AF083497 phospholipase D11251 0.04245 1.54 up Mm.28327 2510049I19Rik 97864_at AW258842 RIKEN cDNA 2510049I19 gene1252 0.04245 1.76 down Mm.18651 Lorsdh 103389_at AJ224761 lysine oxoglutarate reductase, saccharopine dehydrogenase1253 0.04248 7.86 up Mm.2496 Ina 94334_f_at L27220 internexin neuronal intermediate filament protein, alpha1254 0.04249 1.26 down Mm.27733 1110034F20Rik 97217_at AI842095 RIKEN cDNA 1110034F20 gene1255 0.04256 1.59 down Mm.6836 Arf1 101016_at D87898 ADP-ribosylation factor 11256 0.04258 1.39 up Mm.833 Ap1s1 160552_at M62418 adaptor protein complex AP-1, sigma 11257 0.04261 3.85 up Mm.24928 C76972 95857_at C76972 expressed sequence C769721258 0.04263 1.73 up Mm.25194 Myo1c 95506_at U96723 myosin Ic1259 0.04264 1.39 down Mm.21185 Ap3b1 103878_at AF103809 adaptor-related protein complex AP-3, beta 1 subunit1260 0.04266 2.29 up Mm.2995 Ect2 97411_at L11316 ect2 oncogenePage 14 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description1261 0.04270 3.26 up Mm.3468 Cish3 162206_f_at AV374868 cytokine inducible SH2-containing protein 31262 0.04273 3.74 up Mm.3894 Fkbp10 162414_f_at AV320580 FK506 binding protein 10 (65 kDa)1263 0.04275 2.72 up Mm.29625 Mm.29625 97351_i_at AW123567 ESTs, Weakly similar to COXG MOUSE CYTOCHROME C OXIDASE POLY1264 0.04282 1.39 down Mm.6636 4930564D15Rik 93440_at AA692530 RIKEN cDNA 4930564D15 gene1265 0.04287 1.47 down Mm.27404 1110002A21Rik 96675_at AW124245 RIKEN cDNA 1110002A21 gene1266 0.04289 2.21 up 100616_at AF0127101267 0.04291 1.34 down Mm.27624 C530002L11Rik 96710_at AI854262 RIKEN cDNA C530002L11 gene1268 0.04291 3.66 up Mm.5199 Cyp19 101200_at D00659 cytochrome P450, 19, aromatase1269 0.04295 7.30 up Mm.1721 Lipe 161411_i_at AV315398 lipase, hormone sensitive1270 0.04301 1.75 down Mm.28465 Lrp10 96186_at AI839286 low-density lipoprotein receptor-related protein 101271 0.04303 1.34 down Mm.20207 2510029B14Rik 93551_at AW121424 RIKEN cDNA 2510029B14 gene1272 0.04307 1.82 up Mm.10474 3110005M08Rik 92577_f_at AW047116 RIKEN cDNA 3110005M08 gene1273 0.04314 1.55 down Mm.24411 1110017N23Rik 103739_at AW230977 RIKEN cDNA 1110017N23 gene1274 0.04321 2.17 up Mm.30465 Cktsf1b1 101758_at AF045801 cysteine knot superfamily 1, BMP antagonist 11275 0.04325 2.65 up Mm.6253 Crygs 93391_at AF032995 crystallin, gamma S1276 0.04328 9.32 up Mm.46856 Pawr 162434_i_at AV307886 PRKC, apoptosis, WT1, regulator1277 0.04333 2.09 up Mm.858 Igtp 160933_at U53219 interferon gamma induced GTPase1278 0.04335 1.24 up Mm.7405 Bat4 101416_f_at L76155 HLA-B associated transcript 41279 0.04336 1.58 down Mm.8911 Psmb5 101741_at AB003305 proteasome (prosome, macropain) subunit, beta type 51280 0.04341 2.73 up Mm.5510 Mm.5510 161484_r_at AV077293 Mus musculus, Similar to gene overexpressed in astrocytoma, clone IMAGE1281 0.04344 3.50 up Mm.24310 Mm.24310 95903_at AI842525 ESTs1282 0.04347 3.14 up Mm.27584 AW547774 102115_r_at AI482351 expressed sequence AW5477741283 0.04352 2.61 up Mm.448 Cyba 100059_at M31775 cytochrome b-245, alpha polypeptide1284 0.04354 1.35 up Mm.22884 2410012M21Rik 94843_at AW045413 RIKEN cDNA 2410012M21 gene1285 0.04359 2.27 up Mm.218758 Pcdha14 101769_at AB008178 protocadherin alpha 141286 0.04363 2.68 up Mm.20164 3110050F08Rik 103607_at AI882309 RIKEN cDNA 3110050F08 gene1287 0.04364 3.71 up Mm.34102 Odc 162386_at AV255366 ornithine decarboxylase, structural1288 0.04366 1.57 down Mm.29702 D3Ucla1 95708_at AI843466 DNA segment, Chr 3, University of California at Los Angeles 11289 0.04369 1.45 up Mm.29746 Mrpl3 95734_at AI852230 mitochondrial ribosomal protein L31290 0.04379 1.60 down Mm.142872 Hnrpk 94041_at AI840643 heterogeneous nuclear ribonucleoprotein K1291 0.04379 1.39 up Mm.21577 Mm.21577 103449_at AA795923 ESTs1292 0.04380 2.60 up Mm.3180 Tnfrsf18 104662_at U82534 tumor necrosis factor receptor superfamily, member 181293 0.04384 2.80 up Mm.28859 Gnai1 97195_at U38501 guanine nucleotide binding protein, alpha inhibiting 11294 0.04392 1.52 down Mm.3886 2810012H18Rik 99080_at AI853930 RIKEN cDNA 2810012H18 gene1295 0.04393 2.73 up Mm.201109 C77386 95963_at C77386 expressed sequence C773861296 0.04396 1.88 up Mm.4375 Smstr2 99889_at AF030441 somatostatin receptor 21297 0.04403 1.56 down Mm.181830 Ntan1 96666_at U57692 N-terminal Asn amidase1298 0.04409 1.82 down Mm.41043 AW545363 99129_at AW124529 expressed sequence AW5453631299 0.04411 1.54 down Mm.27107 5730536A07Rik 96613_at AI852095 RIKEN cDNA 5730536A07 gene1300 0.04418 2.71 up Mm.903 Btg2 101583_at M64292 B-cell translocation gene 2, anti-proliferative1301 0.04424 1.44 down Mm.18729 Copb2 93341_r_at AF043120 coatomer protein complex, subunit beta 2 (beta prime)1302 0.04432 1.39 down Mm.4179 Irf6 92440_at U73029 interferon regulatory factor 61303 0.04433 1.55 up Mm.30177 2700047N05Rik 160395_at AW046672 RIKEN cDNA 2700047N05 gene1304 0.04444 1.33 up Mm.4505 Gart 100066_at U20892 phosphoribosylglycinamide formyltransferase1305 0.04445 2.11 up Mm.104747 Igk-V28 101640_f_at M15593 immunoglobulin kappa chain variable 28 (V28)1306 0.04446 1.59 up Mm.28690 1500026D16Rik 98938_at AI852184 RIKEN cDNA 1500026D16 gene1307 0.04447 1.59 down Mm.27792 0610011C19Rik 97228_at AI844417 RIKEN cDNA 0610011C19 gene1308 0.04452 1.86 up Mm.27575 Zfp68 95521_s_at AB024005 Zinc finger protein 681309 0.04457 1.77 up Mm.193418 Spi1-2 101575_i_at M25529 serine protease inhibitor 1-21310 0.04458 1.50 down Mm.29030 Sh3d5 160320_at U58883 SH3 domain protein 51311 0.04463 3.57 up Mm.27669 Snrpe 161311_at AV080357 small nuclear ribonucleoprotein E1312 0.04467 2.38 up Mm.30109 1110055L24Rik 160387_at AI853900 RIKEN cDNA 1110055L24 gene1313 0.04469 2.21 up Mm.6818 Itgb1bp1 100991_at AI852849 integrin beta 1 binding protein 11314 0.04471 1.61 up Mm.4521 Traf4 100005_at X92346 Tnf receptor associated factor 41315 0.04480 1.48 down Mm.4342 Tjp1 99935_at D14340 tight junction protein 11316 0.04484 2.14 up Mm.200941 Saa2 101306_f_at M17790 serum amyloid A 21317 0.04484 1.38 down Mm.38746 1810017G16Rik 98626_at AW047503 RIKEN cDNA 1810017G16 gene1318 0.04486 4.37 up Mm.1432 Trrp1 94740_g_at U73625 transient receptor protein 11319 0.04493 1.54 up Mm.23925 4833422P03Rik 104573_at AA921069 RIKEN cDNA 4833422P03 gene1320 0.04496 1.75 up Mm.203905 AU021838 95018_r_at AA607053 expressed sequence AU0218381321 0.04499 1.69 up Mm.4186 Pla2g4a 99513_at M72394 phospholipase A2, group IVA (cytosolic, calcium-dependent)1322 0.04505 1.74 up Mm.13859 Rpl41 100213_f_at U93862 ribosomal protein L411323 0.04506 1.73 up Mm.3487 Rpl30 98119_at K02928 ribosomal protein L301324 0.04511 1.19 up Mm.17905 Rpia 103322_at L35034 ribose 5-phosphate isomerase A1325 0.04515 2.62 up Mm.798 5031419I10Rik 93647_at AI152195 RIKEN cDNA 5031419I10 gene1326 0.04516 1.21 down Mm.8131 Ilk 101499_at U94479 integrin linked kinase1327 0.04517 2.64 up 102762_r_at AF0575271328 0.04527 4.01 up Mm.143846 Ptprc 161410_r_at AV313844 protein tyrosine phosphatase, receptor type, C1329 0.04528 3.50 up Mm.548 Cox6c 100551_r_at AW060422 cytochrome c oxidase, subunit VIc1330 0.04531 5.13 up Mm.5137 Doc2b 101191_at D85037 double C2, beta1331 0.04540 1.79 up Mm.35801 C76683 97179_at C76543 expressed sequence C766831332 0.04541 2.27 up Mm.28561 Prkcz 161964_r_at AV367375 protein kinase C, zeta1333 0.04547 1.60 up Mm.28630 Rnac-pending 98923_at AI852608 RNA cyclase homolog1334 0.04552 2.04 down Mm.2642 Pabpc1 100720_at X65553 poly A binding protein, cytoplasmic 11335 0.04558 1.46 down Mm.41502 Fh1 99148_at AI852862 fumarate hydratase 11336 0.04560 1.28 down Mm.21606 Rtn3 97077_f_at AW213991 reticulon 31337 0.04570 5.58 up Mm.22306 1810045K06Rik 161245_r_at AV312754 RIKEN cDNA 1810045K06 gene1338 0.04574 6.29 up Mm.34797 Crabp1 98108_at X15789 cellular retinoic acid binding protein I1339 0.04576 1.65 down Mm.24855 1110020N13Rik 95480_at AI847163 RIKEN cDNA 1110020N13 gene1340 0.04581 2.34 up Mm.6211 Amac1 93386_at AF016712 acyl-malonyl condensing enzyme1341 0.04590 1.81 up Mm.26166 Acp1 104160_at AW049866 acid phosphatase 1, soluble1342 0.04594 2.49 up Mm.195071 Pcdha11 101772_r_at AB008182 protocadherin alpha 111343 0.04597 3.89 up Mm.14087 C4bp 102799_at M17122 complement component 4 binding protein1344 0.04600 3.49 up Mm.198513 AI266795 95454_at AI266795 expressed sequence AI2667951345 0.04602 3.12 up Mm.3075 Dnajb3 97480_f_at U95607 DnaJ (Hsp40) homolog, subfamily B, member 31346 0.04603 3.22 up Mm.12955 Kcna7 94193_at AF032099 potassium voltage-gated channel, shaker-related subfamily, member 71347 0.04606 1.68 up Mm.42247 Rbms2 92517_at AB026583 RNA binding motif, single stranded interacting protein 21348 0.04609 3.16 up Mm.41886 Gfra2 92449_at AF002701 glial cell line derived neurotrophic factor family receptor alpha 21349 0.04611 2.22 down Mm.10103 Zfp98 94101_at AB007407 zinc finger protein 981350 0.04614 1.76 up Mm.1129 Rps2 100686_at M20632 ribosomal protein S2Page 15 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description1351 0.04620 1.68 up Mm.157069 Dlk1 101975_at Z12171 delta-like 1 homolog (Drosophila)1352 0.04622 3.89 up Mm.14116 Gabrr1 100675_at AF024620 gamma-aminobutyric acid (GABA-A) receptor, subunit rho 11353 0.04623 1.54 down Mm.30181 Map17-pending 96935_at AW011791 membrane-associated protein 171354 0.04624 2.77 up Mm.22982 AI326115 104523_at AI049391 expressed sequence AI3261151355 0.04624 2.71 up 99374_at M124821356 0.04632 1.60 down Mm.15351 1110054N06Rik 93054_at AI846368 RIKEN cDNA 1110054N06 gene1357 0.04634 2.00 up Mm.5866 D18Ertd232e 99823_r_at C79676 DNA segment, Chr 18, ERATO Doi 232, expressed1358 0.04638 2.19 up Mm.86686 H2-M10.1 100305_g_at AI449957 histocompatibility 2, M region locus 10.11359 0.04638 1.77 down Mm.7884 1810010A06Rik 101490_at AW122692 RIKEN cDNA 1810010A06 gene1360 0.04645 2.26 up Mm.21981 AI327276 162339_r_at AV113685 expressed sequence AI3272761361 0.04651 1.36 up Mm.30252 4121402D02Rik 97935_at AI842970 RIKEN cDNA 4121402D02 gene1362 0.04651 1.86 up Mm.3747 2210414H16Rik 160465_at AA882285 RIKEN cDNA 2210414H16 gene1363 0.04653 1.31 up Mm.41486 2700001K05Rik 99147_at AI843986 RIKEN cDNA 2700001K05 gene1364 0.04654 1.46 up Mm.787 Psmb10 101486_at Y10875 proteasome (prosome, macropain) subunit, beta type 101365 0.04657 1.83 up Mm.7221 Lrp1 101073_at X67469 low density lipoprotein receptor-related protein 11366 0.04658 1.95 down Mm.27900 1810013D10Rik 97265_at AI835060 RIKEN cDNA 1810013D10 gene1367 0.04659 2.84 up Mm.149029 Siat1 94432_at AI117157 sialyltransferase 1 (beta-galactoside alpha-2,6-sialyltransferase)1368 0.04663 1.78 up Mm.57096 Htr1d 101764_at X94908 5-hydroxytryptamine (serotonin) receptor 1D1369 0.04674 1.62 down Mm.2726 Itpr1 94977_at X15373 inositol 1,4,5-triphosphate receptor 11370 0.04675 4.68 up Mm.1382 Krt2-17 94703_at M24151 keratin complex 2, basic, gene 171371 0.04680 1.88 down Mm.28548 Lpin1 98892_at AI846934 lipin 11372 0.04682 1.56 up Mm.3484 Npc1 98114_at AF003348 Niemann Pick type C11373 0.04687 2.35 up Mm.28184 2210408E11Rik 161310_at AV079187 RIKEN cDNA 2210408E11 gene1374 0.04688 2.41 up Mm.24897 Mm.24897 95852_at C76202 ESTs1375 0.04694 4.39 up Mm.4078 Mki67 99457_at X82786 antigen identified by monoclonal antibody Ki 671376 0.04697 1.79 down Mm.29816 Pdcd6ip 96252_at AJ005073 programmed cell death 6 interacting protein1377 0.04699 1.80 up Mm.15918 Map3k1 103020_s_at AI317205 mitogen activated protein kinase kinase kinase 11378 0.04704 2.39 up Mm.66913 Zfp60 93447_at AA220047 zinc finger protein 601379 0.04705 1.55 down Mm.43212 1500031M19Rik 99619_at AI847483 RIKEN cDNA 1500031M19 gene1380 0.04705 1.22 down Mm.30167 Mm.30167 97923_at AW046532 Mus musculus, clone MGC:38846 IMAGE:5360921, mRNA, complete cds1381 0.04705 1.62 down Mm.214593 Prkcsh 100684_at U92794 protein kinase C substrate 80K-H1382 0.04706 1.64 down Mm.18847 Wrnip 103415_at AI840925 Werner syndrome homolog (human) interacting protein1383 0.04711 2.37 down Mm.20964 Gnao 161902_f_at AV374213 guanine nucleotide binding protein, alpha o1384 0.04713 2.96 up Mm.10098 Nsccn1 96414_at D50656 non-selective cation channel 11385 0.04717 2.49 up Mm.21005 Cst9 103296_at Y18243 cystatin 91386 0.04718 2.62 up Mm.5237 Ddef1 100513_at AF075461 development and differentiation enhancing1387 0.04719 1.86 down Mm.3105 Zfpm1 97974_at AF006492 zinc finger protein, multitype 11388 0.04719 2.49 up Mm.1098 Gpiap1 161232_r_at AV276689 GPI-anchored membrane protein 11389 0.04719 3.50 up Mm.46089 1600031J20Rik 160504_at AI197077 RIKEN cDNA 1600031J20 gene1390 0.04720 1.44 down Mm.19834 0610033L03Rik 93531_at AI853855 RIKEN cDNA 0610033L03 gene1391 0.04722 3.73 up Mm.30138 1110014F24Rik 96908_at AW060590 RIKEN cDNA 1110014F24 gene1392 0.04733 2.98 up Mm.34248 Dab2 98044_at U18869 disabled homolog 2 (Drosophila)1393 0.04734 2.62 up Mm.86487 Pspn 100298_at AF040960 persephin1394 0.04736 1.63 down Mm.794 R75223 101449_at AW120841 expressed sequence R752231395 0.04737 1.74 down Mm.42234 Dguok 99544_at AA980916 deoxyguanosine kinase1396 0.04739 1.88 up Mm.24291 Mm.24291 103727_at AI850972 ESTs1397 0.04757 1.75 up Mm.34801 Mrpl55 98109_at AI839528 mitochondrial ribosomal protein L551398 0.04769 2.89 up Mm.1021 Vcam1 92559_at U12884 vascular cell adhesion molecule 11399 0.04773 1.70 up Mm.4449 Endog 160494_at AB012108 endonuclease G1400 0.04775 6.26 up Mm.25083 Mm.25083 96482_at C80635 ESTs1401 0.04780 1.50 down Mm.87521 Pip5k1b 104663_at D86177 phosphatidylinositol-4-phosphate 5-kinase, type 1 beta1402 0.04780 3.91 up Mm.3900 Ltbp2 92335_at AF004874 latent transforming growth factor beta binding protein 21403 0.04783 1.73 up Mm.22723 Mm.22723 94823_at AI835315 Mus musculus, ribosomal protein L23a, clone IMAGE:4988735, mRNA, parti1404 0.04784 1.62 up Mm.21373 Igfbp6 103904_at X81584 insulin-like growth factor binding protein 61405 0.04785 3.10 up Mm.12825 Rbp2 92811_at X74154 retinol binding protein 2, cellular1406 0.04785 1.92 down Mm.24510 Slc12a7 104719_at AI182203 solute carrier family 12, member 71407 0.04789 2.45 down Mm.126873 Ppie 102278_at AA597254 peptidylprolyl isomerase E (cyclophilin E)1408 0.04789 1.47 down Mm.28111 2210409M21Rik 97797_at AW123142 RIKEN cDNA 2210409M21 gene1409 0.04803 2.60 up Mm.40339 Cysltr1-pending 94159_at D50872 cysteinyl leukotriene receptor 11410 0.04808 2.02 down Mm.155620 Pla2g6 97965_at U88624 phospholipase A2, group VI1411 0.04815 1.87 down Mm.146332 C87808 102859_at AW121304 expressed sequence C878081412 0.04816 2.00 down Mm.4514 Aldh1a1 100068_at M74570 aldehyde dehydrogenase family 1, subfamily A11413 0.04823 1.63 up Mm.133851 1500031N16Rik 160431_at AW124432 RIKEN cDNA 1500031N16 gene1414 0.04823 1.63 up Mm.25264 Ddx21 94361_at AI836083 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21 (RNA helicase II/Gu)1415 0.04827 2.17 up Mm.24381 Ppp3cb 97989_at M81483 protein phosphatase 3, catalytic subunit, beta isoform1416 0.04836 1.76 up Mm.181894 2900092E17Rik 162165_f_at AV360672 RIKEN cDNA 2900092E17 gene1417 0.04837 2.20 down Mm.158423 5730543C08Rik 93614_at AA600647 RIKEN cDNA 5730543C08 gene1418 0.04837 2.51 up Mm.2863 Itm1 161285_r_at AV299547 intergral membrane protein 11419 0.04845 1.91 up Mm.3304 Nsg2 160413_at U17259 neuron specific gene family member 21420 0.04848 3.43 up Mm.46309 2010013B10Rik 97702_at AU015180 RIKEN cDNA 2010013B10 gene1421 0.04862 2.87 up Mm.1211 Tiam1 161845_at AV331929 T-cell lymphoma invasion and metastasis 11422 0.04875 1.66 up Mm.3511 Matn2 98475_at U69262 matrilin 21423 0.04893 2.22 down Mm.22061 Sema4a 94063_at X85991 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) an1424 0.04893 2.61 up Mm.46797 Adrb1 102151_at L10084 adrenergic receptor, beta 11425 0.04894 1.67 down Mm.4053 Tln 99448_at X56123 talin1426 0.04906 1.71 up Mm.33903 Sema4d 160836_at U69535 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) an1427 0.04909 4.13 up Mm.25160 Mm.25160 161943_at AV341572 ESTs1428 0.04909 2.55 up Mm.24174 AI316495 161526_r_at AV226134 expressed sequence AI3164951429 0.04911 1.84 up Mm.200796 AV028413 161698_f_at AV232762 expressed sequence AV0284131430 0.04916 3.43 up Mm.5032 Prph2 101169_at X14770 peripherin 21431 0.04917 2.27 up Mm.26658 Il10ra 96525_at L12120 interleukin 10 receptor, alpha1432 0.04919 1.70 up Mm.16080 Dnm 103031_g_at L31397 dynamin1433 0.04923 1.45 down Mm.23889 4632417G13Rik 94885_at AI840062 RIKEN cDNA 4632417G13 gene1434 0.04932 1.65 down Mm.203896 Lman1 160270_at AW108371 lectin, mannose-binding, 11435 0.04933 2.04 up Mm.41213 Abcb9 92418_at AB027520 ATP-binding cassette, sub-family B (MDR/TAP), member 91436 0.04939 1.82 up Mm.25292 Krt2-16 162328_f_at AV085755 keratin complex 2, basic, gene 161437 0.04957 2.59 up Mm.30366 Pcdha6 101650_at D86917 protocadherin alpha 61438 0.04958 1.87 up Mm.3597 Maged3 92270_at AI847616 melanoma antigen, family D, 31439 0.04962 1.71 down Mm.28584 9030401P18Rik 98906_at AI853035 RIKEN cDNA 9030401P18 gene1440 0.04969 3.11 up Mm.2682 Mep1b 162186_r_at AV369219 meprin 1 betaPage 16 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description1441 0.04978 1.51 up Mm.27856 Ptprk 160760_at L10106 protein tyrosine phosphatase, receptor type, K1442 0.04981 1.69 down Mm.3747 2210414H16Rik 101916_at AA733674 RIKEN cDNA 2210414H16 gene1443 0.04985 1.38 down Mm.29042 2310005O14Rik 94531_at AW124582 RIKEN cDNA 2310005O14 gene1444 0.04986 1.71 down Mm.27591 2400006A19Rik 160239_at AI844762 RIKEN cDNA 2400006A19 gene1445 0.04990 2.76 up Mm.24957 C77545 95965_at C77545 expressed sequence C775451446 0.04990 2.33 up Mm.27668 Mm.27668 161209_r_at AV262402 ESTs, Moderately similar to I57546 Rabin3 - rat [R.norvegicus]1447 0.04997 1.50 down Mm.143830 Actn4 96343_at AI836968 alpha actinin 41448 0.05000 4.26 up Mm.3437 Pald 161564_r_at AV266918 paladin1449 0.05005 4.73 up Mm.20852 Epb4.1l1 103265_r_at AF061283 erythrocyte protein band 4.1-like 11450 0.05009 1.53 down Mm.200876 R74732 160252_at AI840975 expressed sequence R747321451 0.05017 1.65 down Mm.148425 1110028E10Rik 99445_at AW047012 RIKEN cDNA 1110028E10 gene1452 0.05026 1.89 down Mm.29965 2410104I19Rik 96329_at AI837793 RIKEN cDNA 2410104I19 gene1453 0.05027 1.73 up 161329_f_at AV1071531454 0.05033 1.66 up Mm.29088 0610013D04Rik 100758_at AF110520 RIKEN cDNA 0610013D04 gene1455 0.05037 3.46 up Mm.20285 Krt2-19 161174_i_at AV240674 keratin complex 2, basic, gene 191456 0.05039 2.24 down Mm.1192 Igj 102372_at M90766 immunoglobulin joining chain1457 0.05049 2.46 up Mm.3915 Mobp 99047_at U81317 myelin-associated oligodendrocytic basic protein1458 0.05054 3.37 up Mm.27917 1200003E16Rik 161203_f_at AV242890 RIKEN cDNA 1200003E16 gene1459 0.05061 1.70 down Mm.21848 1200015E15Rik 94019_at AI852534 RIKEN cDNA 1200015E15 gene1460 0.05075 5.14 up Mm.4858 Ctsg 92924_at X70057 cathepsin G1461 0.05083 1.91 up Mm.132208 2510001A17Rik 104297_at AW124742 RIKEN cDNA 2510001A17 gene1462 0.05088 4.62 up Mm.4886 Csnd 98814_at V00740 casein delta1463 0.05094 1.68 down Mm.45179 Ciao1-pending 100072_at AW046227 WD40 protein Ciao11464 0.05096 1.60 up Mm.6586 AI836376 161983_f_at AV377350 expressed sequence AI8363761465 0.05098 1.69 down Mm.139787 5930418K15Rik 102870_at AW125272 RIKEN cDNA 5930418K15 gene1466 0.05107 4.03 up Mm.35793 Ssa2 161416_r_at AV318871 Sjogren syndrome antigen A21467 0.05113 1.69 down Mm.38522 Nphp1 98614_at AJ243223 nephronophthisis 1 (juvenile) homolog (human)1468 0.05113 1.61 down Mm.22144 Copz2 104143_at AI843212 coatomer protein complex, subunit zeta 21469 0.05122 2.50 up Mm.30060 2310008N12Rik 96866_at AW047756 RIKEN cDNA 2310008N12 gene1470 0.05125 1.74 down Mm.29000 Stub1 160318_at AI844511 STIP1 homology and U-Box containing protein 11471 0.05128 1.66 down Mm.139738 C77245 94979_at AW121624 expressed sequence C772451472 0.05128 1.59 down Mm.4356 Cnn1 99942_s_at U28932 calponin 11473 0.05128 2.89 up Mm.148348 1500005G05Rik 162254_f_at AV336704 RIKEN cDNA 1500005G05 gene1474 0.05134 3.13 up Mm.7562 Col6a3 101110_at AF064749 procollagen, type VI, alpha 31475 0.05142 1.97 down Mm.73172 Serpina5 161259_f_at AV283483 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, anti1476 0.05143 2.45 up Mm.4191 Oprm 97774_at U19380 opioid receptor, mu1477 0.05145 1.52 up Mm.1451 Mfge8 92880_at M38337 milk fat globule-EGF factor 8 protein1478 0.05147 2.43 up Mm.3968 Map3k7 160854_at D76446 mitogen activated protein kinase kinase kinase 71479 0.05148 1.30 down Mm.34315 AI114950 98051_at AI852808 expressed sequence AI1149501480 0.05148 1.66 down Mm.19027 Mocs2 160637_at AW060325 molybdenum cofactor synthesis 21481 0.05154 1.93 up Mm.46801 Mm.46801 99420_at X94418 M.musculus mRNA (2F7) for IgA V-D-J-heavy chain1482 0.05157 1.92 down Mm.2875 1100001J13Rik 98952_at AW120971 RIKEN cDNA 1100001J13 gene1483 0.05158 2.48 up Mm.9024 Slc30a1 93938_at U17132 solute carrier family 30 (zinc transporter), member 11484 0.05159 1.34 down Mm.34951 Mrpl27 98120_at AI844807 mitochondrial ribosomal protein L271485 0.05162 4.82 up Mm.23502 Sult1b1 104539_at AF022894 sulfotransferase family 1B, member 11486 0.05167 1.49 down Mm.22123 D15Wsu75e 104141_at AI850401 DNA segment, Chr 15, Wayne State University 75, expressed1487 0.05167 1.82 up Mm.2559 Umpk 161167_r_at AV223645 uridine monophosphate kinase1488 0.05170 1.86 up Mm.1645 Dtx1 102924_at U38252 deltex 1 homolog (Drosophila)1489 0.05172 1.52 down Mm.19352 Mm.19352 93512_f_at AW121801 Mus musculus, Similar to Adenosin kinase, clone MGC:6593 IMAGE:3485951490 0.05177 3.12 up Mm.6062 C81600 101612_at C81600 expressed sequence C816001491 0.05182 1.91 up Mm.20693 2810452K22Rik 103664_r_at AA959648 RIKEN cDNA 2810452K22 gene1492 0.05184 1.32 down Mm.27453 D5Wsu31e 96684_at AI846123 DNA segment, Chr 5, Wayne State University 31, expressed1493 0.05186 1.65 down Mm.22494 Urod 94275_at U34691 uroporphyrinogen decarboxylase1494 0.05188 2.00 up Mm.218369 Mm.218369 100379_f_at AI837905 EST1495 0.05191 2.18 up Mm.4561 Mmp11 100016_at Z12604 matrix metalloproteinase 111496 0.05195 1.72 up Mm.219118 Mm.219118 103600_at AW124890 Mus musculus dematin 52 kDa subunit mRNA, complete cds1497 0.05198 1.64 up Mm.25170 3110013H01Rik 160204_at AI838470 RIKEN cDNA 3110013H01 gene1498 0.05199 1.76 down Mm.205830 Gdi1 97313_at U07950 guanosine diphosphate (GDP) dissociation ihibitor 11499 0.05201 1.68 up Mm.21578 Cln8 160671_at AW124836 ceroid-lipofuscinosis, neuronal 81500 0.05222 1.55 down Mm.38433 Wars 161337_f_at AV121930 tryptophanyl-tRNA synthetase1501 0.05223 1.46 down Mm.30050 Pdcd8 96858_at AF100927 programmed cell death 8 (apoptosis inducing factor)1502 0.05229 4.41 up Mm.37952 Krt1-24 98997_f_at AF020790 keratin complex 1, acidic, gene 241503 0.05230 1.81 up Mm.1484 Hcph 102851_s_at M68902 hemopoietic cell phosphatase1504 0.05234 1.85 down Mm.27510 Usp21 95027_at AW050342 ubiquitin specific protease 211505 0.05238 1.61 down Mm.15312 Tst 160085_at U35741 thiosulfate sulfurtransferase, mitochondrial1506 0.05244 2.46 up Mm.1894 Cd1d1 103422_at M63695 CD1d1 antigen1507 0.05247 1.97 up 94517_r_at M551811508 0.05248 2.35 up Mm.144089 Pdgfb 99890_at M64849 platelet derived growth factor, B polypeptide1509 0.05260 4.52 up Mm.140810 Mm.140810 101124_at AA522008 ESTs, Weakly similar to YO11 MOUSE HYPOTHETICAL PROTEIN ORF-111510 0.05263 2.70 up Mm.42190 Uncx4.1 92499_at AJ001116 Unc4.1 homeobox (C. elegans)1511 0.05266 1.97 up Mm.3731 AA408865 97687_at AA408865 expressed sequence AA4088651512 0.05271 4.19 up Mm.4815 Ccna1 92911_at X84311 cyclin A11513 0.05276 2.80 down Mm.5341 Defb1 100882_at AF003525 defensin beta 11514 0.05282 1.38 down Mm.28385 1810009M01Rik 97885_at AB031386 RIKEN cDNA 1810009M01 gene1515 0.05296 1.65 up Mm.5381 Mrpl45 100886_f_at AI841415 mitochondrial ribosomal protein L451516 0.05297 1.60 down Mm.142822 Ewsh 94810_at X79233 Ewing sarcoma homolog1517 0.05302 3.14 down Mm.28405 Sgk 97890_at AW046181 serum/glucocorticoid regulated kinase1518 0.05314 1.66 down Mm.8686 1200014H14Rik 101675_at AI447407 RIKEN cDNA 1200014H14 gene1519 0.05314 4.50 up Mm.197551 Hspa8 161200_i_at AV257761 heat shock 70kD protein 81520 0.05316 2.32 up Mm.29098 AU015645 162038_f_at AV372745 expressed sequence AU0156451521 0.05323 1.59 down Mm.22676 Pdhb 94806_at AW125336 pyruvate dehydrogenase (lipoamide) beta1522 0.05328 1.84 down Mm.7821 Tpd52l1 101446_at AF004428 tumor protein D52-like 11523 0.05329 1.90 down Mm.157900 1300007C21Rik 103562_f_at M26005 RIKEN cDNA 1300007C21 gene1524 0.05335 1.29 down Mm.18921 Vcp 100710_at Z14044 valosin containing protein1525 0.05343 1.44 down Mm.41271 AI852671 99471_at AF158183 expressed sequence AI8526711526 0.05344 2.19 down Mm.196478 AA536966 160608_at AI854462 expressed sequence AA5369661527 0.05351 1.87 up Mm.1137 Itgb2 102353_at M31039 integrin beta 21528 0.05357 2.62 up Mm.42019 Myo1f 101708_at X97650 myosin If1529 0.05359 3.05 down Mm.27772 2810002D13Rik 160752_at AA667021 RIKEN cDNA 2810002D13 gene1530 0.05359 2.14 up Mm.141150 2410012H22Rik 93138_at AI853219 RIKEN cDNA 2410012H22 genePage 17 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description1621 0.05746 1.52 down Mm.1710 Hmbs 93258_at M28666 hydroxymethylbilane synthase1622 0.05748 1.58 up Mm.2237 Ap1m1 161439_f_at AV349844 adaptor-related protein complex AP-1, mu subunit 11623 0.05766 5.79 up Mm.8245 Timp 101464_at V00755 tissue inhibitor of metalloproteinase1624 0.05781 1.39 down Mm.28842 Clcn3 102786_at AI849432 chloride channel 31625 0.05783 4.97 up 101917_at M262711626 0.05784 2.58 up Mm.5172 Traf6 98874_at D84655 Tnf receptor-associated factor 61627 0.05784 2.40 up Mm.2927 Zfp30 104438_at AI153791 zinc finger protein 301628 0.05789 3.44 up Mm.3383 Ager 92181_at L33412 advanced glycosylation end product-specific receptor1629 0.05789 1.57 down Mm.20838 Mic2l1 160435_at AW050035 MIC2 (monoclonal Imperial Cancer Research Fund 2)-like 11630 0.05791 1.60 down Mm.3776 Myhca 101072_at AW124250 myosin heavy chain, cardiac muscle, adult1631 0.05792 2.86 up Mm.12814 Fgf17 98730_at AB009250 fibroblast growth factor 171632 0.05802 1.83 up Mm.41780 Gng10 99175_at AI843396 guanine nucleotide binding protein (G protein), gamma 101633 0.05803 2.06 up Mm.1155 Tuba4 92635_at M13444 tubulin alpha 41634 0.05803 4.73 up Mm.10414 Mlf1 102061_at AF100171 myeloid leukemia factor 11635 0.05812 1.88 up Mm.38786 Mm.38786 96745_at AA867881 Mus musculus, clone IMAGE:3586777, mRNA, partial cds1636 0.05817 2.97 up Mm.170508 0610038H21Rik 100995_at AA690742 RIKEN cDNA 0610038H21 gene1637 0.05823 1.68 down Mm.28454 0610027F08Rik 97903_at AW050078 RIKEN cDNA 0610027F08 gene1638 0.05825 1.55 down Mm.27558 Psmd5 96698_at AI835520 proteasome (prosome, macropain) 26S subunit, non-ATPase, 51639 0.05826 2.45 up Mm.4726 Pit1 98788_at D12885 pituitary specific transcription factor 11640 0.05836 1.85 up Mm.103634 Rps19 94068_at AW048899 ribosomal protein S191641 0.05836 2.36 up Mm.1383 Arhgdig 102677_at U73198 Rho GDP dissociation inhibitor (GDI) gamma1642 0.05838 2.35 up Mm.196517 1100001J08Rik 160456_at AW106645 RIKEN cDNA 1100001J08 gene1643 0.05841 1.40 down Mm.9749 Ly57 100772_g_at AF068182 lymphocyte antigen 571644 0.05847 2.71 up Mm.104747 Igk-V28 93087_r_at AA267185 immunoglobulin kappa chain variable 28 (V28)1645 0.05859 1.82 down Mm.29025 Dctn3 94522_at AF098508 dynactin 31646 0.05860 1.91 down Mm.4218 Tob1 99532_at D78382 transducer of ErbB-2.11647 0.05862 2.05 up Mm.27407 Recql 160741_at AB017104 RecQ protein-like1648 0.05879 1.41 down Mm.2026 Birc2 160645_at U88908 baculoviral IAP repeat-containing 21649 0.05883 3.08 up Mm.1391 Gata2 161820_f_at AV377670 GATA binding protein 21650 0.05885 3.77 up Mm.15969 Adam8 103024_at X13335 a disintegrin and metalloprotease domain 81651 0.05885 1.55 down Mm.29649 Tm9sf1 97359_at AI851160 transmembrane 9 superfamily member 11652 0.05886 2.90 up Mm.17235 Csrp3 103084_at D88791 cysteine-rich protein 31653 0.05901 1.75 down Mm.293 Ppp3ca 95092_at J05479 protein phosphatase 3, catalytic subunit, alpha isoform1654 0.05907 1.48 up Mm.18916 Got2 161995_r_at AV328137 glutamate oxaloacetate transaminase 2, mitochondrial1655 0.05916 1.60 up Mm.21230 1200004M23Rik 160664_at AW060656 RIKEN cDNA 1200004M23 gene1656 0.05917 1.94 up Mm.23795 LOC56552 99700_at AF053985 tissue-type vomeronasal neurons putative pheromone receptor V2R11657 0.05924 1.42 down Mm.2706 Atf3 104155_f_at U19118 activating transcription factor 31658 0.05926 1.54 down Mm.163230 D9Ertd85e 94975_at AI845607 DNA segment, Chr 9, ERATO Doi 85, expressed1659 0.05927 2.13 up Mm.42034 Znfn1a4 98277_at AB017615 zinc finger protein, subfamily 1A, 41660 0.05941 2.16 up Mm.27090 C78212 104157_at AW125643 expressed sequence C782121661 0.05952 1.92 up Mm.22506 G7e-pending 104333_at U69488 G7e protein1662 0.05955 4.23 up Mm.7522 Folh1 97089_at AA986395 folate hydrolase1663 0.05958 1.97 up Mm.16234 Itga5 103039_at X79003 integrin alpha 5 (fibronectin receptor alpha)1664 0.05960 1.72 up Mm.2005 5031425D22Rik 103221_at AA940352 RIKEN cDNA 5031425D22 gene1665 0.05966 2.23 up Mm.3590 AA407948 92269_r_at AI836610 EST AA4079481666 0.05976 1.23 down Mm.26991 H13 96117_r_at AI843732 histocompatibility 131667 0.05980 2.42 up Mm.25633 Spaf-pending 94387_at AF016544 spermatogenesis associated factor1668 0.05981 1.51 up Mm.24822 AI593864 103776_at AA597222 expressed sequence AI5938641669 0.05983 1.19 up Mm.5241 Pcsk3 100515_at X54056 proprotein convertase subtilisin/kexin type 31670 0.05984 2.59 down Mm.46418 Chia-pending 160509_at AI594518 chitinase, acidic1671 0.05986 1.90 down Mm.2563 Esrra 102145_f_at AW046732 estrogen related receptor, alpha1672 0.05987 2.07 up Mm.139222 Map3k11 161658_at AV115284 mitogen activated protein kinase kinase kinase 111673 0.05987 1.50 down Mm.22470 Ubl5 94267_i_at AW124386 ubiquitin-like 51674 0.05988 3.08 up Mm.45235 Syt8 92682_at AB026805 synaptotagmin 81675 0.05992 1.46 down Mm.38795 Mad4 99024_at U32395 Max dimerization protein 41676 0.05994 1.54 down Mm.29619 1200007E24Rik 160812_at AW121839 RIKEN cDNA 1200007E24 gene1677 0.05997 2.81 up Mm.15409 Limk1 102888_s_at U15159 LIM-domain containing, protein kinase1678 0.06000 3.81 up Mm.40672 Kcna3 92392_at AI850484 potassium voltage-gated channel, shaker-related subfamily, member 31679 0.06002 1.82 up Mm.21128 2410099E07Rik 103866_at AW124359 RIKEN cDNA 2410099E07 gene1680 0.06007 2.00 up Mm.42102 Tulp1 98296_at AF085681 tubby like protein 11681 0.06009 2.89 up Mm.2161 Apom 162148_r_at AV310855 apolipoprotein M1682 0.06018 2.25 up Mm.200527 2410197A17Rik 92238_at AW122193 RIKEN cDNA 2410197A17 gene1683 0.06025 1.99 up Mm.183608 Mm.183608 161131_r_at AV250694 EST1684 0.06044 4.28 up Mm.4752 Srms 98794_at D26186 src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myri1685 0.06045 1.53 down Mm.12677 Atp5c1 92798_at AA870675 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypepti1686 0.06049 2.62 up Mm.24871 AA675344 95941_at AA675344 expressed sequence AA6753441687 0.06056 2.47 up Mm.5316 Actn3 100879_at AF093775 actinin alpha 31688 0.06066 1.46 down Mm.28202 D16Ertd269e 97822_at AW122689 DNA segment, Chr 16, ERATO Doi 269, expressed1689 0.06066 2.52 up Mm.20350 Mad3 103237_at U32394 Max dimerization protein 31690 0.06075 2.35 down Mm.41170 Klf13 160617_at AW125783 Kruppel-like factor 131691 0.06075 2.33 up Mm.42205 Mm.42205 160452_at U00478 Mus musculus DNaseI precursor mRNA, complete cds1692 0.06082 1.66 down Mm.9749 Ly57 100771_at AF068182 lymphocyte antigen 571693 0.06084 2.12 up Mm.28642 AI428936 161857_r_at AV060123 expressed sequence AI4289361694 0.06084 1.94 down Mm.38151 Adsl 98999_at AA606587 adenylosuccinate lyase1695 0.06085 5.18 up Mm.140956 Nnat 97520_s_at X83569 neuronatin1696 0.06086 2.43 up Mm.766 Scyb9 101436_at M34815 small inducible cytokine B subfamily (Cys-X-Cys), member 91697 0.06095 4.15 up Mm.4669 Adam2 162062_r_at AV276538 a disintegrin and metalloprotease domain 21698 0.06097 1.80 down Mm.104 C78977 99004_r_at AA816070 expressed sequence C789771699 0.06099 1.68 down Mm.6483 Pld3 100607_at AF026124 phospholipase D31700 0.06111 2.65 up Mm.37854 Ptprm 92308_at AI847852 protein tyrosine phosphatase, receptor-type, M1701 0.06113 3.18 up Mm.30303 Cyp3a16 101638_s_at D26137 cytochrome P450, 3a161702 0.06117 5.13 up Mm.3453 C1qc 92223_at X66295 complement component 1, q subcomponent, c polypeptide1703 0.06118 1.77 down Mm.1786 Aprt 93283_at AA869401 adenine phosphoribosyl transferase1704 0.06123 1.91 down Mm.28814 Casp6 94458_at Y13087 caspase 61705 0.06125 2.48 up Mm.28413 2410004C24Rik 162131_f_at AV378780 RIKEN cDNA 2410004C24 gene1706 0.06128 1.48 up Mm.21904 Rab6ip1 104108_at AJ245569 Rab6 interacting protein 11707 0.06128 1.53 down Mm.10530 Acadm 92581_at U07159 acetyl-Coenzyme A dehydrogenase, medium chain1708 0.06134 2.59 up Mm.29257 6530405F15Rik 95916_at AA536958 RIKEN cDNA 6530405F15 gene1709 0.06137 1.35 down Mm.29824 Psa 96259_at U35646 puromycin-sensitive aminopeptidase1710 0.06139 3.91 up Mm.153 2010109K11Rik 102987_at AA874367 RIKEN cDNA 2010109K11 genePage 19 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description1711 0.06143 2.06 up Mm.195444 Ear3 103240_f_at AF017258 eosinophil-associated ribonuclease 31712 0.06151 5.00 up Mm.2160 Kng 93837_at AI786089 kininogen1713 0.06151 2.96 up Mm.335 Hsd3b3 98401_at M77015 hydroxysteroid dehydrogenase-3, delta-3-beta1714 0.06153 1.39 down Mm.25203 Nckap1 95508_at X61453 NCK-associated protein 11715 0.06156 3.12 up Mm.2780 Myh3 160753_at M74753 myosin, heavy polypeptide 3, skeletal muscle, embryonic1716 0.06180 1.43 down Mm.22478 Smarcf1 104331_at AA832935 SWI/SNF related, matrix associated, actin dependent regulator of chromatin,1717 0.06183 1.54 down Mm.2942 Asns 161221_f_at AV253908 asparagine synthetase1718 0.06188 1.51 down Mm.10756 Pfdn2 102252_at Y17393 prefoldin 21719 0.06190 1.14 down Mm.2314 Prkcd 160698_s_at AB011812 protein kinase C, delta1720 0.06193 1.51 down Mm.29778 Armet 95749_at AW122364 arginine-rich, mutated in early stage tumors1721 0.06198 2.16 up Mm.24209 Mesdc2 162231_r_at AV309750 mesoderm development candiate 21722 0.06199 2.95 up Mm.31041 Gstm6 104636_at AJ000413 glutathione S-transferase, mu 61723 0.06199 1.60 up Mm.10280 Lat 102228_at AF036907 linker for activation of T cells1724 0.06200 2.45 up Mm.35868 Srst 101684_r_at X67863 simple repeat sequence-containing transcript1725 0.06202 1.80 up 103832_at AF0971811726 0.06209 1.58 down Mm.205030 Mm.205030 96850_at AI853642 Mus musculus, clone IMAGE:4975180, mRNA1727 0.06212 1.74 up Mm.41938 Mm.41938 160870_at AI847423 Mus musculus adenylyl cyclase 3 (Adcy3) mRNA, complete cds1728 0.06214 2.28 up Mm.28362 AI326478 93584_at V00821 expressed sequence AI3264781729 0.06215 1.61 up Mm.219627 Pgam2 92599_at AF029843 phosphoglycerate mutase 21730 0.06222 1.51 up Mm.254 Tpt1 102599_at X06407 tumor protein, translationally-controlled 11731 0.06222 3.08 up Mm.4516 Mup2 100071_at M16356 major urinary protein 21732 0.06223 1.67 down Mm.180734 Rpa1 95427_at AI843650 replication protein A1 (70 kDa)1733 0.06226 2.75 up Mm.175971 Mm.175971 162391_r_at AV260455 ESTs, Moderately similar to LC4S MOUSE LEUKOTRIENE C4 SYNTHASE1734 0.06228 1.65 down Mm.18634 1810024J13Rik 103381_at AI838735 RIKEN cDNA 1810024J13 gene1735 0.06230 1.47 up Mm.8074 Nrtn 93673_at U78109 neurturin1736 0.06230 1.61 up Mm.20433 Ntsr 95319_at AB017027 neurotensin receptor1737 0.06238 1.57 down Mm.7472 Dcra 162486_f_at AV122030 Down syndrome critical region gene a1738 0.06242 4.58 up Mm.41718 AI448216 162210_r_at AV378802 expressed sequence AI4482161739 0.06245 2.39 up Mm.653 H2-Bf 161365_r_at AV224353 histocompatibility 2, complement component factor B1740 0.06250 3.24 up Mm.395 Ptpn8 92356_at M90388 protein tyrosine phosphatase, non-receptor type 81741 0.06256 3.28 up Mm.16106 C4 103033_at X06454 complement component 4 (within H-2S)1742 0.06259 2.53 up Mm.197698 Htr2b 95332_at AJ012488 5-hydroxytryptamine (serotonin) receptor 2B1743 0.06260 2.41 up Mm.3915 Mobp 99046_at AI834776 myelin-associated oligodendrocytic basic protein1744 0.06281 1.54 down Mm.12758 Fkbp4 92809_r_at X17069 FK506 binding protein 4 (59 kDa)1745 0.06285 2.37 up Mm.24270 Mm.24270 95901_f_at AI662099 ESTs1746 0.06286 1.97 up Mm.4390 Numb 161912_r_at AV377244 numb gene homolog (Drosophila)1747 0.06293 4.44 up Mm.3288 Trim30 98030_at J03776 tripartite motif protein 301748 0.06293 2.97 up Mm.104363 Cyp2d9 162174_at AV003830 cytochrome P450, 2d91749 0.06294 1.89 up Mm.8256 Khdrbs1 101508_at U17961 KH domain containing, RNA binding, signal transduction associated 11750 0.06300 1.60 up Mm.1664 Rab33b 103062_at AB004664 RAB33B, member of RAS oncogene family1751 0.06301 2.23 up Mm.3267 Anxa8 97529_at AJ002390 annexin A81752 0.06301 2.76 up Mm.42240 Zfp162 161894_r_at AV103574 zinc finger protein 1621753 0.06302 2.10 up Mm.604 Tnni3 100921_at U09181 troponin I, cardiac1754 0.06307 2.60 up Mm.24521 AA407930 161376_f_at AV243059 expressed sequence AA4079301755 0.06309 2.34 up Mm.40566 Ppfia4 103943_at AI838513 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacti1756 0.06313 2.87 up Mm.24842 2310046B19Rik 162034_r_at AV369210 RIKEN cDNA 2310046B19 gene1757 0.06318 1.48 up Mm.29196 Cyc1 162469_r_at AV069997 cytochrome c-11758 0.06324 1.85 up Mm.190386 Gja5 101778_at X61675 gap junction membrane channel protein alpha 51759 0.06331 1.68 up Mm.7319 Frda 101407_at U95736 Friedreich ataxia1760 0.06340 2.45 up Mm.304 Rb1 97948_at M26391 retinoblastoma 11761 0.06350 2.61 up Mm.19119 2210402C18Rik 103560_at AW124401 RIKEN cDNA 2210402C18 gene1762 0.06353 2.40 up Mm.3249 Epha4 104673_at X65138 Eph receptor A41763 0.06365 2.05 up Mm.3243 Procr 98018_at L39017 protein C receptor, endothelial1764 0.06366 1.91 up Mm.1949 Col6a2 93517_at Z18272 procollagen, type VI, alpha 21765 0.06367 1.77 down Mm.6534 Capns1 100610_at AF058298 calpain, small subunit 11766 0.06372 1.46 up Mm.218533 1500016H10Rik 98138_at AI854776 RIKEN cDNA 1500016H10 gene1767 0.06388 1.99 up Mm.23856 Mm.23856 160178_r_at AW047190 ESTs, Weakly similar to YAE6_YEAST HYPOTHETICAL 13.4 KD PROTEIN1768 0.06393 2.32 down Mm.30728 Arpp19-pending 97260_at AW121489 cyclic AMP phosphoprotein, 19 kDa1769 0.06394 2.82 up Mm.196407 Igk-V21 101633_at X16678 immunoglobulin kappa chain variable 21 (V21)1770 0.06400 1.98 up Mm.5388 Mm.5388 93177_at AW121661 ESTs1771 0.06401 2.65 up Mm.22030 Ha1r-pending 161279_f_at AV291749 Hoxa1 regulated gene1772 0.06402 1.51 down Mm.29588 Mm.29588 95675_at AW121182 Mus musculus, Similar to mitogen-activated protein kinase kinase kinase kin1773 0.06403 3.39 up Mm.3092 Inhbb 160828_at X69620 inhibin beta-B1774 0.06403 2.50 up Mm.1738 Cd48 103089_at X53526 CD48 antigen1775 0.06405 4.17 up Mm.28395 AU019574 96172_at AA795946 expressed sequence AU0195741776 0.06411 1.74 up Mm.29368 Agtrl1 99368_at AJ007612 angiotensin receptor-like 11777 0.06412 2.95 up Mm.4149 Ncf1 97763_at AB002663 neutrophil cytosolic factor 11778 0.06412 1.68 down Mm.4266 Itm2b 101123_at U76253 integral membrane protein 2B1779 0.06429 1.44 down Mm.18230 1300007B12Rik 93301_at AW124624 RIKEN cDNA 1300007B12 gene1780 0.06430 1.34 up Mm.140151 Sprr1b 100446_r_at X91825 small proline-rich protein 1B1781 0.06433 1.65 up Mm.6803 1500019G21Rik 100987_f_at AW045230 RIKEN cDNA 1500019G21 gene1782 0.06433 1.36 up Mm.29860 Mm.29860 160820_at AW061299 Mus musculus immunoglobulin superfamily receptor PGRL (Pgrl) mRNA, com1783 0.06434 2.85 down Mm.26132 D9Ertd720e 162412_r_at AV317927 DNA segment, Chr 9, ERATO Doi 720, expressed1784 0.06439 2.03 up Mm.36725 2410008G02Rik 98975_at AI019999 RIKEN cDNA 2410008G02 gene1785 0.06443 1.41 down Mm.88061 Ncor1 101536_at U35312 nuclear receptor co-repressor 11786 0.06455 1.82 up Mm.10109 Tert 94104_at AF051911 telomerase reverse transcriptase1787 0.06460 1.97 up Mm.37415 1200009F10Rik 95885_at AA177621 RIKEN cDNA 1200009F10 gene1788 0.06468 1.72 up Mm.116 H2-Oa 100897_f_at AF100956 histocompatibility 2, O region alpha locus1789 0.06481 1.63 down Mm.4387 Bad 99670_at L37296 Bcl-associated death promoter1790 0.06494 2.23 up Mm.232 AW488865 161100_at AV305843 expressed sequence AW4888651791 0.06498 3.48 up Mm.2226 Hmgcr 104285_at M62766 3-hydroxy-3-methylglutaryl-Coenzyme A reductase1792 0.06499 1.91 down Mm.6840 5730507C05Rik 160539_at X66091 RIKEN cDNA 5730507C05 gene1793 0.06499 2.23 up Mm.7336 Cmkbr1l2 93617_at AF030185 chemokine (C-C) receptor 1,-like 21794 0.06500 4.13 up Mm.372 Rps26 98565_at AA755219 ribosomal protein S261795 0.06500 1.26 up Mm.171335 AW125446 95593_at AW125446 expressed sequence AW1254461796 0.06502 2.25 up Mm.20829 Emp3 93593_f_at U87948 epithelial membrane protein 31797 0.06505 1.56 down Mm.13146 Mm.13146 102645_at AI155285 ESTs1798 0.06507 2.16 up Mm.40740 AI605384 99864_at AA608277 expressed sequence AI6053841799 0.06510 2.66 up Mm.210047 Thea 100913_at AI847418 thioesterase, adipose associated1800 0.06511 1.46 down Mm.5197 AI854602 93144_at AI854602 expressed sequence AI854602Page 20 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description1891 0.06894 1.30 up Mm.5246 Ppia 101207_at X52803 peptidylprolyl isomerase A1892 0.06903 1.64 down Mm.28958 Mm.28958 96748_i_at AA619554 ESTs, Weakly similar to T47140 hypothetical protein DKFZp761K1115.1 [H.s1893 0.06917 4.01 up Mm.39486 Mm.39486 97736_at AI838823 ESTs1894 0.06920 2.48 up Mm.8308 Pfc 101468_at X12905 properdin factor, complement1895 0.06927 1.84 up Mm.7202 Mm.7202 99866_at AI642417 ESTs1896 0.06930 1.47 down Mm.139700 6330544B05Rik 98084_at AI849834 RIKEN cDNA 6330544B05 gene1897 0.06934 2.56 up Mm.12929 Fhit 102628_at AF047699 fragile histidine triad gene1898 0.06935 3.21 up Mm.44552 Txnrd1 161043_r_at AV277568 thioredoxin reductase 11899 0.06942 1.31 down Mm.30246 Cd151 97930_f_at AF033620 CD151 antigen1900 0.06943 1.82 up 93583_s_at V008171901 0.06953 1.48 up Mm.4620 Rgnef 92710_at U73199 Rho-guanine nucleotide exchange factor1902 0.06955 2.34 up Mm.29261 Il1f5 104436_at AJ250429 interleukin 1 family, member 5 (delta)1903 0.06957 2.18 up Mm.4197 Mm.4197 101118_at AA511266 ESTs1904 0.06958 4.95 up Mm.413 Mtap2 97760_at M21041 microtubule-associated protein 21905 0.06958 1.73 down Mm.202734 Mgea5 94499_at AI835427 meningioma expressed antigen 5 (hyaluronidase)1906 0.06959 2.13 up Mm.9397 Odf1 101968_at X79446 outer dense fiber of sperm tails 11907 0.06962 1.94 down Mm.157012 Tcrb-V13 101338_f_at AE000664 T-cell receptor beta, variable 131908 0.06965 1.66 down Mm.11535 0710008A13Rik 102356_at AI836272 RIKEN cDNA 0710008A13 gene1909 0.06973 5.15 up Mm.22715 Ctla2b 103518_at X15592 cytotoxic T lymphocyte-associated protein 2 beta1910 0.06973 1.26 down Mm.29814 Sbdn 160361_at AW120963 synbindin1911 0.06975 1.93 down Mm.21288 Mm.21288 103892_r_at AI197161 Mus musculus, clone MGC:11987 IMAGE:3601737, mRNA, complete cds1912 0.06977 1.65 up Mm.26995 Thop1 104025_at AW047185 thimet oligopeptidase 11913 0.06987 1.39 up Mm.18617 3830408D16Rik 103925_at AW120605 RIKEN cDNA 3830408D16 gene1914 0.06989 1.57 down Mm.3077 Nr1i3 104506_at AF009328 nuclear receptor subfamily 1, group I, member 31915 0.06992 1.97 up Mm.1618 Itgal 94764_at M60778 integrin alpha L1916 0.06996 1.49 down Mm.14287 Hspa1l 97809_at AF109906 heat shock 70kD protein 1-like1917 0.07000 5.13 up Mm.27035 Qscn6 96602_g_at AW045751 quiescin Q61918 0.07001 2.61 up Mm.4927 Aco1 100147_at X61147 aconitase 11919 0.07015 1.99 up Mm.57064 Adra1a 101740_at AF031431 adrenergic receptor, alpha 1a1920 0.07016 1.77 up Mm.2945 Cappb1 95141_at U10406 capping protein beta 11921 0.07031 1.60 down Mm.1034 Ppp2r1a 92573_at AB021743 protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha iso1922 0.07036 2.19 down Mm.25110 C81072 96487_at C81072 expressed sequence C810721923 0.07046 1.99 down Mm.28308 Nkx6-2 97859_at AA762325 NK6 transcription factor related, locus 2 (Drosophila)1924 0.07050 1.62 down Mm.183076 2510039O18Rik 96325_at AW124874 RIKEN cDNA 2510039O18 gene1925 0.07053 2.07 up Mm.320 Pola2 98006_at D13546 DNA polymerase alpha 2, 68 kDa1926 0.07054 2.78 up Mm.29394 2410008J01Rik 161323_f_at AV095547 RIKEN cDNA 2410008J01 gene1927 0.07056 1.54 down Mm.17675 ln 96540_at AW228792 leaden1928 0.07057 1.44 up Mm.21228 C79684 103312_f_at AW047929 expressed sequence C796841929 0.07058 1.73 up Mm.25717 Dri2 103970_at AF116847 dead ringer homolog 2 (Drosophila)1930 0.07062 1.46 down Mm.28073 D11Ertd172e 95629_at AI843679 DNA segment, Chr 11, ERATO Doi 172, expressed1931 0.07065 1.59 down Mm.102496 N4wbp5-pending 93025_at AI835257 Nedd4 WW binding protein 51932 0.07067 4.25 up Mm.20973 Lgals7 103846_at AF038562 lectin, galactose binding, soluble 71933 0.07068 1.31 down Mm.3874 Adh5 95765_at U48971 alcohol dehydrogenase 51934 0.07072 1.57 down Mm.28850 DXImx38e 96728_at AI844151 DNA segment, Chr X, Immunex 38, expressed1935 0.07073 1.73 down Mm.27546 8430408O15Rik 161250_at AV277344 RIKEN cDNA 8430408O15 gene1936 0.07093 6.37 up Mm.198677 Mm.198677 103509_at AA798611 Mus musculus 11 days pregnant adult female ovary and uterus cDNA, RIKE1937 0.07103 1.97 up Mm.7236 Ddost 162020_at AV361027 dolichyl-di-phosphooligosaccharide-protein glycotransferase1938 0.07104 2.98 up Mm.200410 Klk9 94716_f_at M17962 kallikrein 91939 0.07104 3.40 up Mm.41158 Adam12 92414_at D50411 a disintegrin and metalloproteinase domain 12 (meltrin alpha)1940 0.07109 2.61 up Mm.147697 Psmd2 92645_at AW125458 proteasome (prosome, macropain) 26S subunit, non-ATPase, 21941 0.07114 1.77 up Mm.451 Akr1b3 162341_r_at AV133992 aldo-keto reductase family 1, member B3 (aldose reductase)1942 0.07114 2.77 up Mm.14450 Mm.14450 94743_f_at M29009 Mouse complement factor H-related protein mRNA, complete cds, clone 9C41943 0.07118 1.36 up Mm.46269 Ins1 97659_r_at X04725 insulin I1944 0.07121 2.92 up Mm.4655 Gal 161591_r_at AV290941 galanin1945 0.07123 1.90 up Mm.5692 C78228 101229_at C78228 expressed sequence C782281946 0.07125 2.73 up Mm.8037 Camk2a 93659_at X14836 calcium/calmodulin-dependent protein kinase II alpha1947 0.07127 1.59 down Mm.20450 Nsbp1 103654_at AB018374 nucleosome binding protein 11948 0.07128 1.82 up Mm.27584 AW547774 161198_r_at AV257404 expressed sequence AW5477741949 0.07128 2.15 up Mm.2553 Pap 96009_s_at D63359 pancreatitis-associated protein1950 0.07131 1.35 up Mm.21874 Psmb3 94025_at AW045339 proteasome (prosome, macropain) subunit, beta type 31951 0.07133 1.81 up Mm.196204 1810047J07Rik 102340_at AA833077 RIKEN cDNA 1810047J07 gene1952 0.07133 1.60 down Mm.28150 Sf3b1 96777_at AW049372 splicing factor 3b, subunit 1, 155 kDa1953 0.07134 2.35 down Mm.28111 2210409M21Rik 161389_f_at AV255078 RIKEN cDNA 2210409M21 gene1954 0.07146 2.35 up Mm.88841 Olfr37a 97002_f_at AJ133427 olfactory receptor 37a1955 0.07158 2.76 up Mm.25085 C80719 96389_at C80719 expressed sequence C807191956 0.07162 3.46 up Mm.42207 Crtl1 92506_at AF098460 cartilage link protein 11957 0.07171 1.49 down Mm.29193 Pdcd7 96802_at AW124656 programmed cell death protein 71958 0.07172 1.65 down Mm.13725 Pcee-pending 102781_at U37351 Paneth cell enhanced expression1959 0.07177 1.49 down Mm.24383 AA409780 160710_at AI846787 expressed sequence AA4097801960 0.07182 1.55 up Mm.90587 Eno1 160568_at AI841389 enolase 1, alpha non-neuron1961 0.07191 2.90 up Mm.43330 0610025G13Rik 99626_i_at AA638667 RIKEN cDNA 0610025G13 gene1962 0.07192 2.31 up Mm.24890 Mm.24890 95943_at C76080 ESTs1963 0.07193 2.50 up Mm.214500 1810027O01Rik 93638_s_at J00579 RIKEN cDNA 1810027O01 gene1964 0.07194 1.56 down Mm.29131 1110049F12Rik 160329_at AA798365 RIKEN cDNA 1110049F12 gene1965 0.07197 3.87 up Mm.19131 C3 93497_at K02782 complement component 31966 0.07201 3.25 up Mm.28870 Mm.28870 94477_at AW123796 Mus musculus, clone MGC:6827 IMAGE:2649084, mRNA, complete cds1967 0.07202 1.90 up Mm.3292 Grin1 104684_at AI847120 glutamate receptor, ionotropic, NMDA1 (zeta 1)1968 0.07207 4.06 up Mm.370 C1qa 98562_at X58861 complement component 1, q subcomponent, alpha polypeptide1969 0.07210 1.46 down Mm.193091 Mm.193091 160414_at AI849431 Mus musculus, clone IMAGE:3708675, mRNA, partial cds1970 0.07212 1.84 up Mm.532 Mm.532 100880_at AA816121 ESTs, Weakly similar to A Chain A, Crystal Structure Of The Human Acyl Pro1971 0.07220 2.93 up Mm.195900 Ryr2 102653_at X78667 ryanodine receptor 2, cardiac1972 0.07227 1.75 up Mm.4161 Krt1-2 97767_at X75649 keratin complex 1, acidic, gene 21973 0.07228 1.33 up Mm.19155 Sfrp2 93503_at U88567 secreted frizzled-related sequence protein 21974 0.07230 1.83 down 104255_at AA7952851975 0.07233 1.42 up Mm.21103 D7Wsu128e 103862_r_at AA388099 DNA segment, Chr 7, Wayne State University 128, expressed1976 0.07237 1.91 up Mm.139222 Map3k11 161615_f_at AV352346 mitogen activated protein kinase kinase kinase 111977 0.07238 1.43 up Mm.28421 2410071B14Rik 97895_f_at AW125218 RIKEN cDNA 2410071B14 gene1978 0.07241 2.28 up Mm.26069 Trfr 103957_at X57349 transferrin receptor1979 0.07242 1.88 down Mm.10027 Prpk 102017_at AF033663 pre-mRNA protein kinase1980 0.07253 2.43 up Mm.6173 Dpysl4 93379_at Y09079 dihydropyrimidinase-like 4Page 22 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description1981 0.07259 1.33 down Mm.2956 Cd9 95661_at L08115 CD9 antigen1982 0.07278 3.10 up Mm.30175 Mm.30175 104487_at AI849211 ESTs1983 0.07285 2.43 up Mm.196461 Nsap1l-pending 95606_at AF093821 NS1-associated protein 1-like1984 0.07285 3.96 up Mm.43824 Cox6a2 99667_at U08439 cytochrome c oxidase, subunit VI a, polypeptide 21985 0.07288 1.82 up Mm.28291 C76439 162003_at AV242343 expressed sequence C764391986 0.07290 1.63 up Mm.4592 Cish 100022_at D89613 cytokine inducible SH2-containing protein1987 0.07294 2.38 up Mm.7254 Ebi3 162357_at AV217944 Epstein-Barr virus induced gene 31988 0.07294 1.34 up Mm.1050 Smarcc1 102062_at U85614 SWI/SNF related, matrix associated, actin dependent regulator of chromatin,1989 0.07295 2.40 up Mm.38498 Krt1-15 160852_at D16313 keratin complex 1, acidic, gene 151990 0.07296 1.60 down Mm.178 Cryab 162308_f_at AV013428 crystallin, alpha B1991 0.07296 1.78 down Mm.29902 D8Ertd814e 96295_at AW122030 DNA segment, Chr 8, ERATO Doi 814, expressed1992 0.07296 2.07 up Mm.39968 Hrc 92371_at AI505355 histidine rich calcium binding protein1993 0.07298 1.74 up Mm.140158 Cyp51 94916_at AW122260 cytochrome P450, 511994 0.07306 1.89 up Mm.2277 Ctsh 94834_at U06119 cathepsin H1995 0.07307 3.24 up Mm.46360 Reg2 161302_r_at AV051312 regenerating islet-derived 21996 0.07309 2.56 down Mm.36900 Tnni1 98561_at AJ242874 troponin I, skeletal, slow 11997 0.07312 1.64 down Mm.28691 AI450346 104403_at AI854118 expressed sequence AI4503461998 0.07326 2.55 up Mm.1104 Ube1x 92617_at X62581 ubiquitin-activating enzyme E1, Chr X1999 0.07335 1.73 up Mm.10689 Punc 94117_f_at AF026465 putative neuronal cell adhesion molecule2000 0.07341 1.43 down Mm.28412 Mms19l 96177_at AI854590 MMS19 (MET18 S. cerevisiae)-like2001 0.07364 1.57 down Mm.2733 Auh 96650_at AI837724 AU RNA binding protein/enoyl-coenzyme A hydratase2002 0.07366 1.63 down Mm.22094 Mm.22094 104136_at AI840413 Mus musculus, clone MGC:37636 IMAGE:5002845, mRNA, complete cds2003 0.07367 2.14 up Mm.4181 Jak3 162394_r_at AV266650 Janus kinase 32004 0.07379 3.80 up Mm.856 Tm4sf1 101522_at L15429 transmembrane 4 superfamily member 12005 0.07383 2.81 up Mm.1068 Bcl3 102239_at M90397 B-cell leukemia/lymphoma 32006 0.07389 2.24 up Mm.183097 2610305M23Rik 94822_at AI843819 RIKEN cDNA 2610305M23 gene2007 0.07391 1.48 down Mm.140243 2010012D11Rik 96231_at AW123780 RIKEN cDNA 2010012D11 gene2008 0.07393 2.27 up Mm.219663 Fbln1 94309_g_at X70853 fibulin 12009 0.07408 1.94 up Mm.24836 C76336 103778_at AI503952 expressed sequence C763362010 0.07411 2.37 up Mm.30010 Arpc1b 96356_at AW214725 actin related protein 2/3 complex, subunit 1B (41 kDa)2011 0.07417 3.55 up Mm.360 Cox5a 161490_at AV081382 cytochrome c oxidase, subunit Va2012 0.07418 2.11 up Mm.143717 Ngef 93178_at AW050346 neuronal guanine nucleotide exchange factor2013 0.07421 3.08 up Mm.13787 Cp 92851_at U49430 ceruloplasmin2014 0.07422 3.00 up Mm.24679 Mm.24679 161865_r_at AV069013 ESTs, Weakly similar to LEUKOTRIENE C4 SYNTHASE [M.musculus]2015 0.07428 1.51 up Mm.7405 Bat4 161235_f_at AV265269 HLA-B associated transcript 42016 0.07429 1.77 down Mm.20722 AU022875 103667_at AA866655 expressed sequence AU0228752017 0.07431 1.75 up Mm.6343 Npm1 101634_at M33212 nucleophosmin 12018 0.07435 2.21 up Mm.28867 Tpp2 96730_at X81323 tripeptidyl peptidase II2019 0.07435 2.33 up Mm.8396 Cmah 93688_at D21826 cytidine monophospho-N-acetylneuraminic acid hydroxylase2020 0.07436 1.65 up Mm.153916 Adora2a 101363_at AI644801 adenosine A2a receptor2021 0.07439 1.32 down Mm.22470 Ubl5 94268_f_at AW124386 ubiquitin-like 52022 0.07441 1.52 up Mm.30153 2410166I05Rik 96917_at AI842137 RIKEN cDNA 2410166I05 gene2023 0.07444 3.26 up Mm.214981 Hist1 93024_at M32460 histone gene complex 12024 0.07445 3.68 up Mm.30386 Homer1-pending 104499_at AB019479 homer, neuronal immediate early gene, 12025 0.07447 1.74 up Mm.4375 Smstr2 98351_g_at AF008914 somatostatin receptor 22026 0.07448 5.66 up Mm.78551 Tex21-pending 93640_s_at AB000682 <strong>test</strong>is expressed gene 212027 0.07477 3.06 up Mm.5150 Dspg3 93136_at D78274 dermatan sulphate proteoglycan 32028 0.07482 2.13 down Mm.87790 Mageb3 95782_at U19033 melanoma antigen, family B, 32029 0.07488 1.61 up Mm.202380 Edg3 92352_at AF108021 endothelial differentiation, sphingolipid G-protein-coupled receptor, 32030 0.07495 3.86 up 101672_at AA6750322031 0.07500 2.49 up Mm.41716 Edil3 94051_at AF031525 EGF-like repeats and discordin I-like domains 32032 0.07509 4.11 up Mm.14089 Cyp1a1 161831_at AV027834 cytochrome P450, 1a1, aromatic compound inducible2033 0.07511 2.51 up Mm.4485 Rgl1 92671_f_at U14103 ral guanine nucleotide dissociation stimulator,-like 12034 0.07513 1.66 up Mm.5379 Nek2 100885_at AF013166 NIMA (never in mitosis gene a)-related expressed kinase 22035 0.07519 1.94 up Mm.200768 Ckap2 104322_at AI121796 cytoskeleton associated protein 22036 0.07520 2.17 up Mm.30034 Timm8a 96849_at AA655369 translocase of inner mitochondrial membrane 8 homolog a (yeast)2037 0.07522 1.37 up Mm.22564 H2-Eb1 102848_f_at AI840577 histocompatibility 2, class II antigen E beta2038 0.07523 3.04 up Mm.7960 Dkk1 99881_at AF030433 dickkopf homolog 1 (Xenopus laevis)2039 0.07525 2.61 up Mm.4521 Traf4 162482_at AV109962 Tnf receptor associated factor 42040 0.07530 2.96 up Mm.31144 D8Ertd362e 97085_at C81370 DNA segment, Chr 8, ERATO Doi 362, expressed2041 0.07535 2.73 up Mm.28558 2600017P15Rik 160303_at AI846542 RIKEN cDNA 2600017P15 gene2042 0.07536 2.24 up Mm.196153 Cgef2-pending 92659_at AF115480 cAMP-regulated guanine nucleotide exchange factor II2043 0.07539 1.46 down Mm.6549 Nab2 100962_at U47543 Ngfi-A binding protein 22044 0.07543 1.63 up Mm.141230 Agpat3 160807_at AW124201 1-acylglycerol-3-phosphate O-acyltransferase 32045 0.07544 2.78 up Mm.22102 6720457D02Rik 103481_at AA623379 RIKEN cDNA 6720457D02 gene2046 0.07554 4.76 up Mm.4554 Laptm5 100012_at U29539 lysosomal-associated protein transmembrane 52047 0.07557 2.14 up Mm.43444 Mad2l1 99632_at U83902 MAD2 (mitotic arrest deficient, homolog)-like 1 (yeast)2048 0.07559 1.68 down Mm.34244 1200007D18Rik 160184_at AA815795 RIKEN cDNA 1200007D18 gene2049 0.07570 2.00 down Mm.157105 Psmc1 161671_at AV141654 protease (prosome, macropain) 26S subunit, ATPase 12050 0.07572 2.22 up Mm.13144 Mm.13144 94203_at AA408453 ESTs2051 0.07577 2.19 up Mm.10801 Stra6 102258_at AF062476 stimulated by retinoic acid gene 62052 0.07579 1.50 down Mm.3248 Tgfb1i1 98019_at L22482 transforming growth factor beta 1 induced transcript 12053 0.07581 4.14 up Mm.1676 Tyki 161186_f_at AV246064 thymidylate kinase family LPS-inducible member2054 0.07586 1.54 up Mm.28207 D4Wsu132e 162178_r_at AV366328 DNA segment, Chr 4, Wayne State University 132, expressed2055 0.07595 3.17 up Mm.13212 C76533 94686_at C76765 expressed sequence C765332056 0.07597 2.96 up Mm.41993 Slc6a3 97787_at AJ238309 solute carrier family 6 (neurotransmitter transporter, dopamine), member 32057 0.07612 1.49 down Mm.4619 Msh2 100033_at X81143 mutS homolog 2 (E. coli)2058 0.07619 3.77 up Mm.173368 Mm.173368 96555_at AU044839 EST2059 0.07625 3.64 up Mm.88775 Tcp10a 100358_s_at X58169 t-complex protein 10a2060 0.07626 1.41 down Mm.86513 5430429D03Rik 103082_at AI847507 RIKEN cDNA 5430429D03 gene2061 0.07626 1.67 up Mm.52252 Mm.52252 98855_r_at AA014745 ESTs, Weakly similar to PGG2 RAT CHONDROITIN SULFATE PROTEOGL2062 0.07627 1.94 up Mm.1403 Myo7a 94713_at U81453 myosin VIIa2063 0.07627 1.44 down Mm.525 Eif4g2 100535_at U76112 eukaryotic translation initiation factor 4, gamma 22064 0.07633 3.72 up Mm.18096 Bpnt1 103336_r_at AI836830 bisphosphate 3'-nucleotidase 12065 0.07635 1.52 down Mm.9221 Rab4a 101921_at D86563 RAB4A, member RAS oncogene family2066 0.07641 4.09 up Mm.202271 AA407862 97749_at AI836270 expressed sequence AA4078622067 0.07642 1.45 down Mm.16421 Hmgb1 93095_at U00431 high mobility group box 12068 0.07650 1.61 up Mm.17306 Tpm3 93266_at U04541 tropomyosin 3, gamma2069 0.07654 1.32 down Mm.90496 Dctn6 160327_at AI848936 dynactin 62070 0.07663 3.88 up Mm.104747 Igk-V28 101329_f_at U55585 immunoglobulin kappa chain variable 28 (V28)Page 23 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description2071 0.07664 2.14 up Mm.5789 Mm.5789 101603_g_at C79108 ESTs2072 0.07674 7.16 up Mm.4218 Tob1 161567_r_at AV356682 transducer of ErbB-2.12073 0.07677 1.50 up Mm.28032 C75969 95618_at AI843884 expressed sequence C759692074 0.07677 2.10 up Mm.14860 Anxa1 93038_f_at M69260 annexin A12075 0.07688 1.65 up Mm.29492 Elovl1 95642_at AI842813 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like2076 0.07689 2.49 up Mm.4692 R75424 92744_at AI854774 expressed sequence R754242077 0.07700 1.55 down Mm.22147 Gtpbp2 104144_at AW124369 GTP binding protein 22078 0.07706 4.55 up Mm.42170 Kif9 161035_at AA122519 kinesin 92079 0.07707 2.80 up Mm.1268 Plp 92802_s_at M16472 proteolipid protein (myelin)2080 0.07709 1.73 down Mm.146516 2310075C12Rik 96271_at AA914105 RIKEN cDNA 2310075C12 gene2081 0.07709 2.68 up Mm.8315 Nedd9 101469_at AF009366 neural precursor cell expressed, developmentally down-regulated gene 92082 0.07727 1.24 down Mm.20885 Golga5 103808_at AB016784 golgi autoantigen, golgin subfamily a, 52083 0.07727 1.55 down Mm.29791 Mbtps1 95754_at AI838216 membrane-bound transcription factor protease, site 12084 0.07731 2.01 up Mm.6900 Grb2 101034_at U07617 growth factor receptor bound protein 22085 0.07732 1.54 down Mm.5885 Tm9sf2 100572_at AI851289 transmembrane 9 superfamily member 22086 0.07735 3.64 up Mm.23845 1600017K21Rik 103676_at AI551306 RIKEN cDNA 1600017K21 gene2087 0.07739 1.88 up Mm.202774 AA407676 161758_r_at AV298880 expressed sequence AA4076762088 0.07742 3.63 up Mm.5697 Mm.5697 93204_r_at AW107463 ESTs2089 0.07743 1.96 up Mm.80559 Mm.80559 162432_f_at AV297484 ESTs, Weakly similar to W01A11.2.p [Caenorhabditis elegans] [C.elegans]2090 0.07749 2.15 down Mm.7226 Tcf2 101396_at AB008174 transcription factor 22091 0.07749 1.66 up Mm.25317 Mm.25317 98346_at AI593759 ESTs, Weakly similar to JG0193 G protein-coupled receptor FEX - mouse [M2092 0.07764 3.95 up Mm.144235 Pxf 95073_at Y09046 peroxisomal farnesylated protein2093 0.07780 3.84 up Mm.5073 Sp4 92991_at U62522 trans-acting transcription factor 42094 0.07783 1.51 down Mm.2368 Timm17a 94860_at AW121821 translocator of inner mitochondrial membrane 17 kDa, a2095 0.07785 1.59 up Mm.7454 AI662457 162460_f_at AV048486 expressed sequence AI6624572096 0.07794 1.40 down Mm.22526 2310004B05Rik 104343_f_at AI845798 RIKEN cDNA 2310004B05 gene2097 0.07801 3.77 up Mm.46754 AI316867 162135_r_at AV379830 expressed sequence AI3168672098 0.07821 2.43 up Mm.57250 Hic1 93231_at AJ007511 hypermethylated in cancer 12099 0.07834 2.58 up Mm.24794 2410001E19Rik 161617_f_at AV354124 RIKEN cDNA 2410001E19 gene2100 0.07839 1.52 down Mm.27670 4831443O22Rik 94242_at AA881309 RIKEN cDNA 4831443O22 gene2101 0.07844 1.86 down Mm.34044 Daf2 92198_s_at L41365 decay accelerating factor 22102 0.07845 1.27 down Mm.28095 AL024016 95637_at AI838592 expressed sequence AL0240162103 0.07848 2.21 up Mm.25049 C79777 95989_at AI448172 expressed sequence C797772104 0.07849 2.56 up Mm.56902 Olfr49 101281_at AF102523 olfactory receptor 492105 0.07864 1.76 up Mm.2020 Csrp2 93550_at D88792 cysteine-rich protein 22106 0.07864 1.78 down Mm.2167 Rev3l 103457_at AF083464 REV3-like, catalytic subunit of DNA polymerase zeta RAD54 like (S. cerevisi2107 0.07867 1.64 down Mm.22670 Mdm2 98110_at AI853375 transformed mouse 3T3 cell double minute 22108 0.07869 2.01 up Mm.28961 Cpsf5 94506_at AI853113 cleavage and polyadenylation specific factor 5, 25 kD subunit2109 0.07879 1.88 up Mm.142716 Fabp6 99977_at U00938 fatty acid binding protein 6, ileal (gastrotropin)2110 0.07895 2.23 up Mm.1367 Wnt3a 102667_at X56842 wingless-related MMTV integration site 3A2111 0.07896 1.44 down Mm.28458 Lrba 104264_at AW122230 LPS-responsive beige-like anchor2112 0.07899 1.34 down Mm.27278 Nme3 94981_i_at AI852470 expressed in non-metastatic cells 32113 0.07899 2.49 up Mm.24204 AV328152 160968_at AI390412 expressed sequence AV3281522114 0.07919 2.26 up Mm.4511 AI504145 160889_at AI846313 expressed sequence AI5041452115 0.07920 3.51 up Mm.197478 Imap38 92489_at Y08026 immunity-associated protein, 38 kDa2116 0.07943 1.85 down Mm.1304 Slc11a2 104451_at AI852578 solute carrier family 11 (proton-coupled divalent metal ion transporters), mem2117 0.07947 1.98 up Mm.4931 Hoxd11 92951_at X71422 homeo box D112118 0.07949 1.58 down Mm.200196 Il15ra 161023_at U22339 interleukin 15 receptor, alpha chain2119 0.07950 1.95 up Mm.5376 1110036H21Rik 100883_at AI877468 RIKEN cDNA 1110036H21 gene2120 0.07952 4.39 up Mm.752 AI848610 101426_at AW125333 expressed sequence AI8486102121 0.07956 2.16 up Mm.21450 2310016E02Rik 93807_at AW122507 RIKEN cDNA 2310016E02 gene2122 0.07959 2.00 up Mm.3925 S100a4 99051_at M36579 S100 calcium binding protein A42123 0.07970 1.29 down Mm.218627 Ppil2 95112_f_at AW122632 peptidylprolyl isomerase (cyclophilin)-like 22124 0.07971 4.50 up Mm.104295 Slc10a1 100340_at U95132 solute carrier family 10 (sodium/bile acid cotransporter family), member 12125 0.07972 2.12 up Mm.2718 Eef1b2 96624_r_at AI837393 eukaryotic translation elongation factor 1 beta 22126 0.07984 3.11 up Mm.10737 Cideb 102329_at AF041377 cell death-inducing DNA fragmentation factor, alpha subunit-like effector B2127 0.07987 3.64 up Mm.20363 Gale 93566_at AI847878 galactose-4-epimerase, UDP2128 0.07989 3.28 up Mm.28577 1110006I11Rik 98902_at AI835066 RIKEN cDNA 1110006I11 gene2129 0.07995 3.02 up Mm.196520 Tcp1-rs1 162443_at AV349894 t-complex protein 1, related sequence 12130 0.07997 2.81 up Mm.10729 Ncf2 102326_at AB002664 neutrophil cytosolic factor 22131 0.08000 2.95 down Mm.29917 2810002B19Rik 96306_at AI852210 RIKEN cDNA 2810002B19 gene2132 0.08000 2.44 up Mm.200955 Catnal1 94174_at AF006071 catenin alpha-like 12133 0.08003 1.45 down Mm.6562 Sult-x1 93434_at AF026074 sulfotransferase-related protein SULT-X12134 0.08012 3.00 up Mm.5193 Klk8 99327_at D30785 kallikrein 82135 0.08014 1.85 up Mm.5593 D5Ertd102e 101225_at C77257 DNA segment, Chr 5, ERATO Doi 102, expressed2136 0.08015 2.59 up Mm.41075 Drd4 97755_at U19880 dopamine receptor 42137 0.08016 1.81 up Mm.37263 Mm.37263 92293_at AI850463 ESTs, Weakly similar to L1 cell adhesion molecule [Mus musculus] [M.musc2138 0.08020 1.74 up Mm.29856 9130022B02Rik 162462_r_at AV054247 RIKEN cDNA 9130022B02 gene2139 0.08021 1.59 down Mm.20851 Pdi3 103803_at AB013849 peptidyl arginine deiminase, type III2140 0.08021 1.89 up Mm.28253 Mm.28253 100296_at X99253 M.musculus mRNA for protein expressed at high levels in <strong>test</strong>is2141 0.08026 1.80 down Mm.10724 Ehf 102243_at AF035527 ets homologous factor2142 0.08032 4.21 up Mm.30413 Bmp8b 101657_at U39545 bone morphogenetic protein 8b2143 0.08039 1.54 down Mm.29771 Atp6a1 95744_at U13837 ATPase, H+ transporting, lysosomal (vacuolar proton pump), alpha 70 kDa, i2144 0.08041 2.41 up Mm.4348 Tnfaip2 160489_at L24118 tumor necrosis factor, alpha-induced protein 22145 0.08052 4.78 up Mm.27970 Mapk13 160763_at U81823 mitogen activated protein kinase 132146 0.08053 5.56 up Mm.46360 Reg2 95786_at D14011 regenerating islet-derived 22147 0.08054 2.45 up 94928_at X871282148 0.08058 2.20 down Mm.19080 Gtpbp1 103436_at U87965 GTP binding protein 12149 0.08067 2.04 up Mm.196549 Mm.196549 161130_f_at AV301574 Mus musculus, Similar to hypothetical protein DKFZp434G0522, clone MGC2150 0.08068 2.18 up Mm.7999 Ptgfrn 99894_at AF006201 prostaglandin F2 receptor negative regulator2151 0.08075 2.84 up Mm.2951 Camk4 104455_at J03057 calcium/calmodulin-dependent protein kinase IV2152 0.08075 1.61 down Mm.28028 Mm.28028 97293_at AI842108 Mus musculus, Similar to RNA binding motif protein 10, clone MGC:7826 IMA2153 0.08076 2.39 up Mm.157893 Mup1 161815_f_at AV355798 major urinary protein 12154 0.08084 2.43 up Mm.5157 Oa1 98871_at X98352 mouse homolog of human ocular albinism 1 (Nettleship-Falls)2155 0.08086 3.08 up Mm.14255 Apbb1ip-pending 102710_at AF020313 amyloid beta (A4) precursor protein-binding, family B, member 1 interacting p2156 0.08087 2.64 up Mm.1440 Tac1 102726_at D17584 tachykinin 12157 0.08095 2.29 up Mm.20874 Pdi4 103278_at AB013850 peptidyl arginine deiminase, type IV2158 0.08098 3.86 up Mm.30313 Ncam2 96582_at AF001287 neural cell adhesion molecule 22159 0.08102 3.22 up Mm.27822 Apobec2 97236_r_at AW124988 apolipoprotein B editing complex 22160 0.08103 2.69 up Mm.29738 Apoa5 95727_at AI785422 apolipoprotein A-VPage 24 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description2161 0.08120 1.77 down Mm.7039 1190003A07Rik 101053_at AW046847 RIKEN cDNA 1190003A07 gene2162 0.08128 2.01 up Mm.814 D10Ertd398e 101500_at AI834796 DNA segment, Chr 10, ERATO Doi 398, expressed2163 0.08146 2.16 up Mm.4646 Krt1-13 160510_f_at U13921 keratin complex 1, acidic, gene 132164 0.08147 1.69 down Mm.4290 1110020G17Rik 97279_at AI837615 RIKEN cDNA 1110020G17 gene2165 0.08153 1.86 up Mm.4463 Vipr2 98375_at D28132 vasoactive in<strong>test</strong>inal peptide receptor 22166 0.08156 2.60 up Mm.18036 E2f1 161427_f_at AV301683 E2F transcription factor 12167 0.08160 1.42 down Mm.142827 DXImx46e 96813_f_at AI852973 DNA segment, Chr X, Immunex 46, expressed2168 0.08160 1.45 down Mm.87450 1110018F06Rik 103348_at AI837688 RIKEN cDNA 1110018F06 gene2169 0.08164 1.48 down Mm.154456 Cyb561 103423_at AI846517 cytochrome b-5612170 0.08170 2.28 up Mm.25170 3110013H01Rik 162491_f_at AV140903 RIKEN cDNA 3110013H01 gene2171 0.08170 3.06 up Mm.14269 Defcr-rs1 102814_f_at M33226 defensin related sequence cryptdin peptide (paneth cells)2172 0.08173 1.72 down Mm.3536 Myo5b 92254_at M55253 myosin Vb2173 0.08174 1.52 down Mm.21435 Sec61a2-pending 103913_at AI851315 SEC61, alpha subunit 2 (S. cerevisiae)2174 0.08176 1.51 down Mm.2291 Tia1 160696_at U00689 cytotoxic granule-associated RNA binding protein 12175 0.08180 3.58 up Mm.22224 Cpx1-pending 103492_at AF077738 metallocarboxypeptidase 12176 0.08189 2.45 up Mm.2953 Grin2a 100726_at D10217 glutamate receptor, ionotropic, NMDA2A (epsilon 1)2177 0.08203 1.54 down Mm.29405 Rbx1 95125_f_at AW122337 ring-box 12178 0.08205 2.75 up Mm.206505 D11Bwg1104e 160116_at AI850047 DNA segment, Chr 11, Brigham & Women's Genetics 1104 expressed2179 0.08212 1.36 down Mm.43636 Zfp289 99644_at AI845855 zinc finger protein 2892180 0.08220 2.93 up Mm.1346 Itga4 102655_at X53176 integrin alpha 42181 0.08248 1.97 up Mm.14465 Gzmc 161834_at AV035955 granzyme C2182 0.08250 3.97 up Mm.26237 Cry1 94421_r_at AB000777 cryptochrome 1 (photolyase-like)2183 0.08255 2.27 up Mm.795 Csf1 101450_at M21952 colony stimulating factor 1 (macrophage)2184 0.08256 1.64 up Mm.35793 Ssa2 92265_f_at AF042139 Sjogren syndrome antigen A22185 0.08257 1.97 down Mm.9326 Rnf13 101966_s_at AF037206 ring finger protein 132186 0.08265 1.96 up Mm.89854 Adam11 93920_at AB009676 a disintegrin and metalloprotease domain 112187 0.08269 1.35 down Mm.21684 Cab39 93976_at AI836686 calcium binding protein, 39 kDa2188 0.08269 1.82 up Mm.6958 Capn2 162112_i_at AV295948 calpain 22189 0.08270 2.86 up Mm.24399 Klra1 95908_at M25775 killer cell lectin-like receptor, subfamily A, member 12190 0.08272 1.53 up Mm.24331 Asb3 104629_at AI876546 ankyrin repeat and SOCS box-containing protein 32191 0.08279 2.22 up Mm.5703 C78334 101231_at C78334 expressed sequence C783342192 0.08280 1.83 down Mm.42948 Prdx2 99608_at U20611 peroxiredoxin 22193 0.08280 4.60 up Mm.4833 Htr5b 98810_at X69867 5-hydroxytryptamine (serotonin) receptor 5B2194 0.08295 1.83 up Mm.200388 Siat5 100279_at X76989 sialyltransferase 52195 0.08296 5.46 up Mm.21795 Mm.21795 161481_f_at AV068206 ESTs, Highly similar to I38863 E1B 19K/Bcl-2-interacting protein Nip1 [H.sap2196 0.08298 2.56 up Mm.7952 Peg3 101451_at AF038939 paternally expressed 32197 0.08298 2.30 down Mm.26171 Lce-pending 103665_at AW122523 long chain fatty acyl elongase2198 0.08302 6.18 up Mm.42791 Crtam 98334_at AF001104 cytotoxic and regulatory T cell molecule2199 0.08306 4.09 up Mm.24851 Mm.24851 162211_r_at AV379320 ESTs2200 0.08329 2.36 up Mm.28697 2310032D16Rik 98941_r_at AA823901 RIKEN cDNA 2310032D16 gene2201 0.08333 1.94 down Mm.10080 Kcnk3 102020_at AB013345 potassium channel, subfamily K, member 32202 0.08340 3.15 up Mm.196322 X83313 100348_at AW214136 EST X833132203 0.08343 1.72 up Mm.38976 AA409661 99085_at AI021421 expressed sequence AA4096612204 0.08351 1.54 down Mm.201339 AW060250 95530_at AW060250 expressed sequence AW0602502205 0.08352 2.67 up Mm.4980 Chrne 92966_g_at J04698 cholinergic receptor, nicotinic, epsilon polypeptide2206 0.08360 2.88 up Mm.21013 Gro1 95349_g_at J04596 GRO1 oncogene2207 0.08363 2.13 up Mm.200362 Cybb 100300_at U43384 cytochrome b-245, beta polypeptide2208 0.08363 3.03 up Mm.5134 Grik1 93132_at X66118 glutamate receptor, ionotropic, kainate 12209 0.08366 1.65 down Mm.28209 Perp-pending 97825_at AI854029 p53 apoptosis effector related to Pmp222210 0.08372 4.30 up Mm.142733 Scn1a 162255_s_at AV336781 sodium channel, voltage-gated, type I, alpha polypeptide2211 0.08378 2.34 up Mm.27521 AA409802 161606_f_at AV345792 expressed sequence AA4098022212 0.08383 1.32 down Mm.147641 Clk3 93311_at AF033565 CDC-like kinase 32213 0.08391 1.69 down Mm.45951 1200016B17Rik 92872_at AI837715 RIKEN cDNA 1200016B17 gene2214 0.08392 2.20 up Mm.18087 Lgals9 103335_at U55060 lectin, galactose binding, soluble 92215 0.08409 3.83 up Mm.897 Pou2af1 162439_at AV346238 POU domain, class 2, associating factor 12216 0.08410 2.54 up Mm.6826 Aatk 100994_at AF011908 apoptosis-associated tyrosine kinase2217 0.08413 1.92 up Mm.8020 Otog 94625_at U96411 otogelin2218 0.08420 1.33 down Mm.21281 Rnf4 93782_at AI844517 ring finger protein 42219 0.08421 1.50 down Mm.28872 Rab5a 94478_at AI841377 RAB5A, member RAS oncogene family2220 0.08428 2.03 up Mm.5305 Gnb2-rs1 99340_at D29802 guanine nucleotide binding protein, beta 2, related sequence 12221 0.08435 2.26 up Mm.6246 Blr1 99841_at X71788 Burkitt lymphoma receptor 12222 0.08447 3.18 up Mm.46817 V1rb6 102167_at Y17567 vomeronasal 1 receptor, B62223 0.08448 2.99 up Mm.1282 Scya3 102424_at J04491 small inducible cytokine A32224 0.08457 3.16 up Mm.6047 2410002E02Rik 161072_at AV352144 RIKEN cDNA 2410002E02 gene2225 0.08464 1.64 up Mm.2543 Ihh 103949_at X76291 Indian hedgehog homolog, (Drosophila)2226 0.08467 1.37 down Mm.27987 AI606441 95609_at AA869927 expressed sequence AI6064412227 0.08470 3.86 up Mm.38315 Mm.38315 92320_f_at AA415783 ESTs, Weakly similar to ZF26 MOUSE ZINC FINGER PROTEIN 26 [M.musc2228 0.08472 3.59 up Mm.41576 Kif5c 98827_i_at X61435 kinesin family member 5C2229 0.08480 2.05 up Mm.28328 Hsd11b1 97867_at X83202 hydroxysteroid 11-beta dehydrogenase 12230 0.08487 2.12 up Mm.10661 Slc2a4 102314_at M23383 solute carrier family 2 (facilitated glucose transporter), member 42231 0.08490 3.23 up Mm.9212 Sema6a 100762_at AF030430 sema domain, transmembrane domain (TM), and cytoplasmic domain, (sema2232 0.08495 2.94 up Mm.24876 Elf1 161584_r_at AV318048 E74-like factor 12233 0.08509 2.95 up Mm.5167 Nov 100507_at Y09257 nephroblastoma overexpressed gene2234 0.08515 1.65 up Mm.15675 Efna1 103007_at U90662 ephrin A12235 0.08515 2.38 down Mm.154284 Slc22a9 92486_at AB018436 solute carrier family 22 (organic cation transporter), member 92236 0.08517 1.32 up Mm.200499 Eif2ak1 160341_at AW122189 eukaryotic translation initiation factor 2 alpha kinase 12237 0.08524 5.61 up Mm.62569 Mm.62569 161448_f_at AV355612 EST2238 0.08524 1.79 up Mm.18425 3110056M06Rik 103356_at AI843267 RIKEN cDNA 3110056M06 gene2239 0.08534 2.05 up Mm.5348 1700010P14Rik 162047_f_at AV264876 RIKEN cDNA 1700010P14 gene2240 0.08536 1.62 down Mm.30076 Bat1a 160384_at AF118128 HLA-B-associated transcript 1A2241 0.08539 2.42 up Mm.10137 Il16 102029_at AF017111 interleukin 162242 0.08540 2.89 up Mm.88833 Mm.88833 100370_at AJ011033 Mus musculus strain ILS K-Cl cotransporter (Slc12a5) mRNA, complete cds2243 0.08541 1.34 down Mm.27653 Zfp106 95533_at AW048037 zinc finger protein 1062244 0.08547 1.37 up Mm.28029 0710001O20Rik 160263_r_at AI840981 RIKEN cDNA 0710001O20 gene2245 0.08552 1.74 up Mm.5048 Mcmd5 100156_at D26090 mini chromosome maintenance deficient 5 (S. cerevisiae)2246 0.08557 2.14 up Mm.24903 C76332 95854_at C76332 expressed sequence C763322247 0.08563 1.82 down Mm.22459 AI265322 104327_at AA755234 expressed sequence AI2653222248 0.08573 3.14 up Mm.104747 Igk-V28 100322_at U48716 immunoglobulin kappa chain variable 28 (V28)2249 0.08574 2.00 up Mm.29497 2310020H20Rik 95645_at AI837440 RIKEN cDNA 2310020H20 gene2250 0.08576 4.99 up Mm.3401 Pcsk5 92192_s_at D12619 proprotein convertase subtilisin/kexin type 5Page 25 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description2251 0.08587 3.17 up Mm.90048 Esrrb 100301_at X89594 estrogen related receptor, beta2252 0.08592 2.93 up Mm.214548 Bmp6 92372_at X80992 bone morphogenetic protein 62253 0.08597 1.82 down Mm.200406 Mm.200406 98463_at AW124186 Mus musculus, Similar to SWI/SNF related, matrix associated, actin depende2254 0.08598 1.39 down Mm.10265 Nmt1 102047_at AF043326 N-myristoyltransferase 12255 0.08600 2.49 up Mm.7693 Stk2 101437_at AF039574 serine/threonine kinase 22256 0.08608 1.86 down Mm.5238 AU024132 104316_at AI646098 expressed sequence AU0241322257 0.08613 2.03 up Mm.10948 Slfn1 102264_at AF099972 schlafen 12258 0.08618 1.88 up Mm.25620 Dntt 161409_f_at AV312871 deoxynucleotidyltransferase, terminal2259 0.08627 1.49 down Mm.1465 AI449533 102862_at AA873956 expressed sequence AI4495332260 0.08636 1.64 up Mm.25189 C85331 94349_at AA794923 expressed sequence C853312261 0.08636 2.75 up Mm.4797 Gsh1 101146_at U21224 genomic screened homeo box 12262 0.08638 1.87 down Mm.196027 Cpr2-pending 95341_at U89434 cell cycle progression 2 protein2263 0.08643 1.65 down Mm.6384 Nrap 160913_at U76618 nebulin-related anchoring protein2264 0.08651 1.95 up Mm.7 Vim 101046_at X56397 vimentin2265 0.08653 2.58 up Mm.89205 Jnkbp1-pending 97054_at AB029482 Jun N-terminal kinase binding protein 12266 0.08667 1.41 up Mm.143813 Midn 104410_at AW124785 midnolin2267 0.08672 1.88 up Mm.25296 2310079N02Rik 94366_at AW121767 RIKEN cDNA 2310079N02 gene2268 0.08676 1.69 down Mm.218907 AI854876 99948_at AI854876 expressed sequence AI8548762269 0.08676 2.64 up Mm.22569 Ccnb1-rs1 160159_at X64713 cyclin B1, related sequence 12270 0.08678 2.37 up Mm.5324 A030009H04Rik 160905_s_at AI840713 RIKEN cDNA A030009H04 gene2271 0.08680 1.48 down Mm.641 Atf4 100599_at M94087 activating transcription factor 42272 0.08682 1.71 up Mm.46816 V1rb5 102165_at Y17566 vomeronasal 1 receptor, B52273 0.08683 1.47 down Mm.20242 1810044O22Rik 96878_at AW048566 RIKEN cDNA 1810044O22 gene2274 0.08689 2.61 up Mm.10211 Entpd5 92561_at AJ238636 ectonucleoside triphosphate diphosphohydrolase 52275 0.08696 3.11 up Mm.27644 Mm.27644 96538_at AA472923 ESTs, Weakly similar to ANK1 MOUSE ANKYRIN 1 [M.musculus]2276 0.08701 1.82 down Mm.3308 Ywhah 97535_at D87661 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,2277 0.08708 1.62 up Mm.27673 D6Wsu176e 97770_s_at AA733372 DNA segment, Chr 6, Wayne State University 176, expressed2278 0.08709 3.10 up Mm.21961 Atp6s1 103699_i_at AI646638 ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 12279 0.08721 1.96 up Mm.200569 Zfp260 92409_at D45210 zinc finger protein 2602280 0.08722 1.81 down Mm.12787 2400010G15Rik 102421_at AI847950 RIKEN cDNA 2400010G15 gene2281 0.08725 2.67 up Mm.7914 Gdf1 93642_at M62301 growth differentiation factor 12282 0.08730 2.88 up Mm.25191 Mm.25191 96492_at AI593265 ESTs2283 0.08741 1.49 down Mm.29667 2010320B01Rik 160814_at AI854547 RIKEN cDNA 2010320B01 gene2284 0.08743 1.44 down Mm.4259 Tacstd1 99582_at M76124 tumor-associated calcium signal transducer 12285 0.08752 1.33 down Mm.200237 1110034O24Rik 104071_at AI852433 RIKEN cDNA 1110034O24 gene2286 0.08753 1.56 up Mm.14609 Aldh1a7 94778_at U96401 aldehyde dehydrogenase family 1, subfamily A72287 0.08755 2.84 up Mm.31126 C79562 97080_at C79288 expressed sequence C795622288 0.08761 2.49 up Mm.1296 Tpx1 162454_f_at AV039214 <strong>test</strong>is specific gene 12289 0.08763 1.45 down Mm.24086 3930401E15Rik 94903_at AI850801 RIKEN cDNA 3930401E15 gene2290 0.08765 1.40 down Mm.5750 2310032K15Rik 100904_at AI852257 RIKEN cDNA 2310032K15 gene2291 0.08772 1.70 up Mm.4038 Fxr1h 99121_at X90875 fragile X mental retardation gene 1, autosomal homolog2292 0.08779 1.85 down Mm.123240 1700016D08Rik 104122_at AW122596 RIKEN cDNA 1700016D08 gene2293 0.08780 1.49 down Mm.19761 AA589616 103580_at AI845588 expressed sequence AA5896162294 0.08782 1.49 up Mm.3080 Mm.3080 97966_at AI848209 Mus musculus, Similar to coactivator independent of AF-2, clone MGC:288642295 0.08788 1.59 up Mm.218381 ep 161367_f_at AV232610 pale ear2296 0.08790 1.41 down Mm.29058 Sra1 160323_at AW122167 steroid receptor RNA activator 12297 0.08791 1.24 down Mm.30064 Gabarap 96869_at AW124839 gamma-aminobutyric acid receptor associated protein2298 0.08792 1.66 up Mm.2212 P4ha1 104139_at U16162 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), a2299 0.08793 2.74 up Mm.1430 Eya3 102716_at U81604 eyes absent 3 homolog (Drosophila)2300 0.08794 1.43 up Mm.21705 1110049G11Rik 161872_f_at AV073962 RIKEN cDNA 1110049G11 gene2301 0.08800 2.43 up Mm.193459 Mglap 93866_s_at D00613 matrix gamma-carboxyglutamate (gla) protein2302 0.08802 4.12 up Mm.2128 S100a9 103887_at M83219 S100 calcium binding protein A9 (calgranulin B)2303 0.08825 3.88 up Mm.14131 Tcstv1-pending 94727_f_at AF067057 2-cell-stage, variable group, member 12304 0.08828 2.01 up Mm.21114 Mm.21114 93463_at AW122517 Mus musculus, clone MGC:11980 IMAGE:3601364, mRNA, complete cds2305 0.08841 3.22 down Mm.214548 Bmp6 161028_at AI850533 bone morphogenetic protein 62306 0.08847 1.82 up Mm.4293 Sax1 98337_at X75384 spinal cord axial homeobox gene 12307 0.08850 2.16 up Mm.2121 1110013J02Rik 93775_at AI841894 RIKEN cDNA 1110013J02 gene2308 0.08851 1.61 down Mm.8556 Cbx4 93697_at U63387 chromobox homolog 4 (Drosophila Pc class)2309 0.08859 2.94 up Mm.1262 Cyp17 161721_f_at AV262299 cytochrome P450, 172310 0.08860 2.13 up Mm.29070 1810042K04Rik 94543_at AW049487 RIKEN cDNA 1810042K04 gene2311 0.08862 5.35 up Mm.23897 Mm.23897 162437_at AV345587 ESTs2312 0.08867 3.02 up Mm.38376 Rad1 99005_at AF073523 RAD1 homolog (S. pombe)2313 0.08867 2.08 up Mm.26096 Akp5 103991_at M61704 alkaline phosphatase 52314 0.08869 1.29 up Mm.28103 1810009A15Rik 103565_at AI843358 RIKEN cDNA 1810009A15 gene2315 0.08871 2.10 up Mm.14098 Cyp2b19 102690_at AF047529 cytochrome P450, 2b192316 0.08874 1.30 down Mm.195084 Tubb2 94835_f_at M28739 tubulin, beta 22317 0.08878 2.25 up Mm.23710 1200011C15Rik 104550_at AW123273 RIKEN cDNA 1200011C15 gene2318 0.08879 1.99 up Mm.200511 AI115024 103889_at AI834833 expressed sequence AI1150242319 0.08887 1.46 down Mm.19803 2310047C21Rik 93529_at AW125219 RIKEN cDNA 2310047C21 gene2320 0.08892 1.50 up Mm.2706 Atf3 161645_r_at AV084197 activating transcription factor 32321 0.08893 1.54 up Mm.182445 Ldlb 160210_at AF109377 low density lipoprotein B2322 0.08905 2.03 up Mm.142568 Disp-pending 93709_at AJ243866 distal in<strong>test</strong>inal serine protease2323 0.08908 1.56 down Mm.29594 Sart3 97340_at AI839599 squamous cell carcinoma antigen recognized by T-cells 32324 0.08919 3.72 up Mm.147946 Mybbp1a 101010_at U63648 MYB binding protein (P160) 1a2325 0.08921 1.61 down Mm.22397 1300013G12Rik 104311_at AW125241 RIKEN cDNA 1300013G12 gene2326 0.08921 2.88 up Mm.3645 Myo5a 161948_f_at AV214912 myosin Va2327 0.08923 1.56 up Mm.29061 Rrr-pending 96778_at AA656775 regulator for ribosome resistance homolog (S. cerevisiae)2328 0.08925 1.68 down Mm.41785 Fibp 99176_at AI843393 fibroblast growth factor (acidic) intracellular binding protein2329 0.08926 3.81 up Mm.157783 AI893585 101747_f_at X94419 expressed sequence AI8935852330 0.08926 2.33 up Mm.6204 Cort 99831_at AF013253 cortistatin2331 0.08932 3.37 up Mm.3327 AW121776 97110_at AW121776 expressed sequence AW1217762332 0.08939 2.72 up Mm.8025 Abpa 94628_r_at AF039064 androgen binding protein, alpha2333 0.08947 1.55 down Mm.1960 Mm.1960 103211_at AI852574 ESTs, Weakly similar to beta-transducin [Caenorhabditis elegans] [C.elegan2334 0.08947 1.44 up Mm.4117 Cdc37 99135_at U43076 cell division cycle 37 homolog (S. cerevisiae)2335 0.08949 2.84 up Mm.34934 C77614 97139_at C77614 EST C776142336 0.08952 1.74 down Mm.41939 1110018D06Rik 99196_at AI848532 RIKEN cDNA 1110018D06 gene2337 0.08952 1.68 up Mm.4487 Anpep 99993_at U77083 alanyl (membrane) aminopeptidase2338 0.08953 1.58 down Mm.42188 Unc13h1 92498_at AF115848 unc13 homolog (C. elegans) 12339 0.08955 2.69 up Mm.3468 Cish3 92232_at U88328 cytokine inducible SH2-containing protein 32340 0.08972 4.17 up Mm.4405 Chx10 161711_f_at AV246437 C. elegans ceh-10 homeo domain containing homologPage 26 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description2341 0.08975 2.88 up Mm.16086 Abcb1a 102910_at M24417 ATP-binding cassette, sub-family B (MDR/TAP), member 1A2342 0.08976 2.14 up Mm.5178 Mylc2pl 101195_at X65979 myosin light chain 2, precursor lymphocyte-specific2343 0.08976 2.53 up Mm.2549 Hk2 94375_at Y11666 hexokinase 22344 0.08979 1.43 up Mm.197534 Baiap2 103098_at AW045765 brain-specific angiogenesis inhibitor 1-associated protein 22345 0.08980 1.28 down Mm.42234 Dguok 99543_s_at AJ133749 deoxyguanosine kinase2346 0.08982 3.25 up Mm.34248 Dab2 98045_s_at U18869 disabled homolog 2 (Drosophila)2347 0.08983 1.91 up Mm.29119 AI195470 95043_at AI047331 expressed sequence AI1954702348 0.08989 3.88 up Mm.14874 Gzmb 102877_at M12302 granzyme B2349 0.08990 1.53 down Mm.206786 Tor1b 95505_at AW060509 torsin family 1, member B2350 0.08995 4.27 up Mm.181623 Mm.181623 161091_r_at AV337823 ESTs2351 0.08996 2.05 up Mm.6840 5730507C05Rik 160141_r_at AI843342 RIKEN cDNA 5730507C05 gene2352 0.08997 2.21 up Mm.103849 Mm.103849 99016_at AA589431 EST, Weakly similar to JAK3 MOUSE TYROSINE-PROTEIN KINASE JAK32353 0.09005 1.90 up Mm.28954 Wrch1-pending 162011_f_at AV246963 Wnt1 responsive Cdc42 homolog2354 0.09006 1.63 down Mm.3037 1700031C13Rik 97947_at AI836959 RIKEN cDNA 1700031C13 gene2355 0.09013 1.78 up Mm.5473 AU021092 93185_at AW045808 expressed sequence AU0210922356 0.09024 1.56 up Mm.22753 Ctsb 92256_at AI853714 cathepsin B2357 0.09025 2.87 up Mm.1909 Gbp3 103202_at AW047476 guanylate nucleotide binding protein 32358 0.09028 1.44 down Mm.46397 3100002B05Rik 103650_at AI846887 RIKEN cDNA 3100002B05 gene2359 0.09035 1.27 down Mm.29623 Ddb1 95683_g_at AB026432 damage specific DNA binding protein 1 (127 kDa)2360 0.09035 3.32 up Mm.33781 Mm.33781 97117_at AA027631 ESTs2361 0.09041 4.11 up Mm.5357 AI447490 161932_r_at AV312014 EST AI4474902362 0.09049 1.50 up Mm.41552 Mm.41552 92259_at AI467526 Mus musculus, clone MGC:28734 IMAGE:4460615, mRNA, complete cds2363 0.09059 4.17 up Mm.4778 Cspg3 98799_g_at X84727 chondroitin sulfate proteoglycan 32364 0.09062 1.47 down Mm.23713 Mm.23713 160702_at AA791885 ESTs, Weakly similar to S48081 GRSF-1 protein [H.sapiens]2365 0.09073 1.45 down Mm.121721 Stat6 94331_at L47650 signal transducer and activator of transcription 62366 0.09076 1.75 up 104458_at AI8412352367 0.09082 1.99 up Mm.97734 Cd38 100778_at L11332 CD38 antigen2368 0.09095 4.36 up Mm.24237 AV046379 161102_at AA242553 expressed sequence AV0463792369 0.09095 1.38 up Mm.12267 MGC6685 92775_at AA656757 similar to poly(A)-binding protein, cytoplasmic 4 (inducible form)2370 0.09111 1.76 down Mm.29998 0610039C21Rik 96348_at AW121217 RIKEN cDNA 0610039C21 gene2371 0.09116 3.49 up Mm.2258 Utg 94291_at L04503 uteroglobin2372 0.09129 2.05 up Mm.27224 2410006H10Rik 94971_at AI317217 RIKEN cDNA 2410006H10 gene2373 0.09130 2.13 up Mm.22240 Sh3bgrl3 94220_at AI836226 SH3 domain binding glutamic acid-rich protein-like 32374 0.09135 1.96 up Mm.34747 Slc4a4 98457_at AF020195 solute carrier family 4 (anion exchanger), member 42375 0.09145 1.55 down Mm.27235 4933405K21Rik 96635_at AW125392 RIKEN cDNA 4933405K21 gene2376 0.09148 4.11 up Mm.89474 Cd80 93905_at L12589 CD80 antigen2377 0.09152 1.36 down Mm.911 Hmgn2 101589_at X12944 high mobility group nucleosomal binding domain 22378 0.09157 2.38 up Mm.21882 Cd84 94028_f_at AI642245 CD84 antigen2379 0.09167 1.53 up Mm.2424 Rpl10a 161327_f_at AV104703 ribosomal protein L10A2380 0.09168 1.73 down Mm.3380 Kif5b 160417_at U86090 kinesin family member 5B2381 0.09170 3.04 up Mm.35692 Il1rl1 98501_at Y07519 interleukin 1 receptor-like 12382 0.09182 1.77 up Mm.24720 Fkbp7 104746_at AF040252 FK506 binding protein 7 (23 kDa)2383 0.09185 3.83 up Mm.28362 AI326478 101744_i_at X94422 expressed sequence AI3264782384 0.09186 1.48 down Mm.22597 2310042E05Rik 94299_at AI839731 RIKEN cDNA 2310042E05 gene2385 0.09191 1.50 down Mm.22530 Exo70 104345_at AF014461 exocyst component protein 70 kDa homolog (S. cerevisiae)2386 0.09200 1.63 up Mm.482 Jun 100130_at X12761 Jun oncogene2387 0.09203 1.36 up Mm.28256 Narg1-pending 96152_at AI645561 NMDA receptor-regulated gene 12388 0.09210 2.47 up Mm.569 Vdac2 161255_at AV282090 voltage-dependent anion channel 22389 0.09212 1.88 up Mm.10563 Mtf2 103657_i_at AI836552 metal response element binding transcription factor 22390 0.09218 1.79 up Mm.70127 Rpl12 101049_at L04280 ribosomal protein L122391 0.09219 1.62 down Mm.3705 P4ha2 162188_f_at AV370017 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), a2392 0.09219 1.54 down Mm.675 Oaz2 101000_at D78643 ornithine decarboxylase antizyme 22393 0.09222 4.57 up Mm.104644 Mm.104644 160478_r_at AV216394 EST2394 0.09222 2.26 up Mm.4491 Prpmp5-pending 98382_f_at X63004 proline-rich protein MP52395 0.09222 3.93 up Mm.28767 Crp 96229_at X13588 C-reactive protein, petaxin related2396 0.09226 3.11 up Mm.34257 1190008A14Rik 160419_r_at AA866869 RIKEN cDNA 1190008A14 gene2397 0.09233 4.36 up Mm.42037 Odz1 101714_at AB025410 odd Oz/ten-m homolog 1 (Drosophila)2398 0.09234 1.37 up Mm.26069 Trfr 103958_g_at X57349 transferrin receptor2399 0.09240 4.48 up Mm.30083 2510015F01Rik 96886_at AW060556 RIKEN cDNA 2510015F01 gene2400 0.09242 1.44 down Mm.1963 Srrm1 93521_at AW049194 serine/arginine repetitive matrix 12401 0.09246 2.18 up Mm.88831 Siat7f 100369_at AB035174 sialytransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acet2402 0.09246 2.83 up Mm.12885 Dach1 94180_s_at AF090437 dachshund 1 (Drosophila)2403 0.09253 2.02 up Mm.4475 Btk 92668_at L10627 Bruton agammaglobulinemia tyrosine kinase2404 0.09253 3.51 up Mm.218846 Lbp 96123_at X99347 lipopolysaccharide binding protein2405 0.09253 3.83 up Mm.24741 Slc1a1 104748_s_at D43797 solute carrier family 1, member 12406 0.09260 2.12 up Mm.6461 Hrb 100954_at AF057287 HIV-1 Rev binding protein2407 0.09269 2.76 up Mm.3322 H2-DMb1 98034_at U35330 histocompatibility 2, class II, locus Mb12408 0.09284 2.80 up Mm.4091 Hcls1 99461_at X84797 hematopoietic cell specific Lyn substrate 12409 0.09287 3.33 up Mm.18527 Dab1 161291_at AV039198 disabled homolog 1 (Drosophila)2410 0.09289 1.27 down Mm.193096 Scd2 162077_f_at AV327760 stearoyl-Coenzyme A desaturase 22411 0.09289 2.22 down Mm.13168 AA516738 94683_at AA516738 expressed sequence AA5167382412 0.09290 1.81 down Mm.21458 1810009A16Rik 104041_at AW122255 RIKEN cDNA 1810009A16 gene2413 0.09291 1.47 down Mm.195451 Gosr2 94072_g_at AI847904 golgi SNAP receptor complex member 22414 0.09298 1.89 up Mm.180455 Slc38a4 104286_at AA795541 solute carrier family 38, member 42415 0.09311 1.84 up Mm.1548 Ggta1 102993_at M85153 glycoprotein galactosyltransferase alpha 1, 32416 0.09311 2.38 up Mm.157012 Tcrb-V13 93105_s_at M26056 T-cell receptor beta, variable 132417 0.09321 1.81 down Mm.4470 Ar 92667_at M37890 androgen receptor2418 0.09321 2.46 up Mm.19379 Lst1 103571_at U72644 leucocyte specific transcript 12419 0.09330 1.66 up Mm.24059 Schip1 160708_at AI840446 schwannomin interacting protein 12420 0.09333 2.15 up Mm.24214 Foxk1 160969_at L26507 forkhead box K12421 0.09336 1.57 up Mm.2339 Ptgis 104538_at AB001607 prostaglandin I2 (prostacyclin) synthase2422 0.09340 2.20 up Mm.22494 Urod 161328_i_at AV106467 uroporphyrinogen decarboxylase2423 0.09349 3.12 up Mm.14897 Cdh2 102852_at M31131 cadherin 22424 0.09355 5.02 up Mm.2679 Agtr2 161212_r_at AV247006 angiotensin II receptor, type 22425 0.09356 1.69 up Mm.5045 Slc16a2 100491_at AF045692 solute carrier family 16 (monocarboxylic acid transporters), member 22426 0.09356 2.26 up Mm.5309 Gabrg2 93163_at M62374 gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 22427 0.09356 3.02 up Mm.26835 Spint2 96101_at AI847090 serine protease inhibitor, Kunitz type 22428 0.09370 1.95 up Mm.18635 Rgs10 161765_f_at AV335997 regulator of G-protein signalling 102429 0.09376 3.62 up Mm.23938 Mm.23938 95882_at AI592102 EST2430 0.09377 2.56 up 94090_at X53493Page 27 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description2431 0.09379 1.53 down Mm.6635 Ivd 104153_at AW047743 isovaleryl coenzyme A dehydrogenase2432 0.09390 1.79 up Mm.4681 Mm.4681 98778_at AI837543 ESTs2433 0.09410 3.18 up Mm.30266 Hbb-b1 160560_at AV107330 hemoglobin, beta adult major chain2434 0.09411 1.70 up Mm.5041 Acvr2 98841_at M65287 activin receptor IIA2435 0.09415 1.18 down Mm.29170 Fbxw5 96797_s_at AW122681 f-box and WD-40 domain protein 52436 0.09417 1.46 down Mm.28999 0610033H09Rik 94518_at AW121749 RIKEN cDNA 0610033H09 gene2437 0.09425 1.44 up Mm.6055 C81234 160907_at AI592789 expressed sequence C812342438 0.09427 1.65 up Mm.12881 Lhx6 94176_at AB031040 LIM homeobox protein 62439 0.09438 1.48 up Mm.3921 Casp2 99049_at D28492 caspase 22440 0.09441 1.57 up Mm.18759 Acads 161469_r_at AV354445 acetyl-Coenzyme A dehydrogenase, short chain2441 0.09442 1.71 down Mm.8911 Psmb5 101558_s_at AB003304 proteasome (prosome, macropain) subunit, beta type 52442 0.09450 1.64 up Mm.7103 Pbx2 98426_at AF030001 pre B-cell leukemia transcription factor 22443 0.09452 3.24 up 100387_f_at AF0281232444 0.09456 2.89 up Mm.142731 Reg1 162312_f_at AV053434 regenerating islet-derived 12445 0.09456 1.95 up Mm.21082 Mm.21082 161741_r_at AV316991 Mus musculus, Similar to hypothetical protein MGC2555, clone MGC:290182446 0.09459 3.40 up Mm.943 Mm.943 100765_at AI592747 ESTs2447 0.09459 2.47 up Mm.18923 Mcmd7 162293_r_at AV377480 mini chromosome maintenance deficient 7 (S. cerevisiae)2448 0.09472 1.58 down Mm.27373 Vps26 96665_at AW211618 vacuolar protein sorting 26 (yeast)2449 0.09475 1.84 up Mm.20446 Fish 95327_at AJ007012 five SH3 domains2450 0.09477 2.09 up Mm.21503 B3gnt1 98291_at AF092050 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 12451 0.09484 1.62 up Mm.6743 Nfe2l1 101757_at AF015881 nuclear factor, erythroid derived 2,-like 12452 0.09489 2.21 up Mm.28178 Krt1-3 162106_f_at AV292406 keratin complex 1, acidic, gene 32453 0.09497 1.70 up Mm.5126 Fadd 100500_at U50406 Fas (TNFRSF6)-associated via death domain2454 0.09498 1.44 down Mm.29651 1110030L07Rik 95690_at AW047363 RIKEN cDNA 1110030L07 gene2455 0.09504 1.41 down Mm.29377 1100001D10Rik 160338_at AW121792 RIKEN cDNA 1100001D10 gene2456 0.09504 2.12 up Mm.4676 Slc7a2 92736_at L03290 solute carrier family 7 (cationic amino acid transporter, y+ system), member 22457 0.09514 3.13 up Mm.5196 Cmklr1 101199_at U79525 chemokine-like receptor 12458 0.09522 1.73 up Mm.29580 Scgn10 95669_g_at AI840972 superiorcervical ganglia, neural specific 102459 0.09531 2.54 up Mm.14277 Saa3 102712_at X03505 serum amyloid A 32460 0.09540 2.85 up Mm.681 Ly68 93454_at AF081789 lymphocyte antigen 682461 0.09555 1.47 down Mm.171292 2010200I23Rik 94882_at AA684506 RIKEN cDNA 2010200I23 gene2462 0.09558 1.63 up Mm.34319 Ywhab 98053_at AF058797 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,2463 0.09562 1.73 down Mm.2237 Ap1m1 94248_at M62419 adaptor-related protein complex AP-1, mu subunit 12464 0.09570 1.78 down Mm.142363 2810036L13Rik 103525_at AA981725 RIKEN cDNA 2810036L13 gene2465 0.09575 1.53 down Mm.29873 AI463719 96284_at AW121446 expressed sequence AI4637192466 0.09576 2.60 up Mm.12246 Ier5 92773_at AF079528 immediate early response 52467 0.09585 3.17 up Mm.20443 Pscd1 95325_at AF051337 pleckstrin homology, Sec7 and coiled/coil domains 12468 0.09585 1.62 down Mm.16537 Acta2 93100_at X13297 actin, alpha 2, smooth muscle, aorta2469 0.09595 1.68 up Mm.4498 Ptpn14 98385_at D31842 protein tyrosine phosphatase, non-receptor type 142470 0.09600 1.51 up Mm.1865 Mm.1865 103388_at AW047050 Mus musculus Myb protein P42POP mRNA, complete cds2471 0.09603 1.45 down Mm.30110 1110025H24Rik 97436_at AA869653 RIKEN cDNA 1110025H24 gene2472 0.09605 1.41 down Mm.88827 Mllt7 96987_at AB032770 myeloid/lymphoid or mixed lineage-leukemia translocation to 7 homolog (Dro2473 0.09607 1.94 up Mm.870 Msx1 101526_at X14759 homeo box, msh-like 12474 0.09613 2.24 down Mm.6205 Mja1l-pending 101621_at AF008595 major allergen 1-like2475 0.09616 1.94 down Mm.26743 Apoa1 101528_at D00925 apolipoprotein A-I2476 0.09620 1.63 down Mm.29769 2310050K10Rik 95743_at AI846078 RIKEN cDNA 2310050K10 gene2477 0.09630 1.89 up Mm.4622 Serpinb5 100034_at U54705 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 52478 0.09634 1.60 up Mm.4140 Gm2a 99141_at U09816 GM2 ganglioside activator protein2479 0.09654 1.72 up Mm.29257 6530405F15Rik 104435_at AI644072 RIKEN cDNA 6530405F15 gene2480 0.09657 2.50 up Mm.1541 Snta1 162147_f_at AV356394 syntrophin, acidic 12481 0.09658 1.83 up Mm.28585 Thrsp 160306_at X95279 thyroid hormone responsive SPOT14 homolog (Rattus)2482 0.09660 2.57 up Mm.35020 Kat2 98123_at AW226961 kynurenine aminotransferase II2483 0.09665 3.22 up Mm.24365 0610042A05Rik 161975_r_at AV372191 RIKEN cDNA 0610042A05 gene2484 0.09673 1.82 up Mm.205578 AA408451 160777_at AI851515 expressed sequence AA4084512485 0.09676 1.57 up Mm.25722 P2rx1 103971_at X84896 purinergic receptor P2X, ligand-gated ion channel, 12486 0.09680 1.72 down Mm.205883 AI323986 102360_at AW214225 expressed sequence AI3239862487 0.09684 1.54 down Mm.193432 ORF18 95477_at AW125185 open reading frame 182488 0.09686 1.30 down Mm.21714 2410003A14Rik 93986_at AA939576 RIKEN cDNA 2410003A14 gene2489 0.09691 2.39 up Mm.1777 Hsp60 161140_r_at AV159556 heat shock protein, 60 kDa2490 0.09707 1.43 up Mm.3012 2900091E11Rik 96902_at AW121847 RIKEN cDNA 2900091E11 gene2491 0.09712 2.95 up Mm.56895 D17H6S56E-3 103719_at AF109905 DNA segment, Chr 17, human D6S56E 32492 0.09734 1.81 up Mm.21878 Pomc1 94026_at J00612 pro-opiomelanocortin-alpha2493 0.09768 2.03 up Mm.10188 Gprk5 102217_at AI639925 G protein-coupled receptor kinase 52494 0.09774 3.15 up Mm.196666 Hsd17b5 92556_at D45850 hydroxysteroid (17-beta) dehydrogenase 52495 0.09784 1.53 up Mm.29738 Apoa5 95728_g_at AI785422 apolipoprotein A-V2496 0.09787 1.37 down Mm.930 Ctsl 101963_at X06086 cathepsin L2497 0.09790 2.66 up Mm.21806 Elovl3 103469_at U97107 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like2498 0.09791 1.61 up Mm.23526 2610036L13Rik 161332_f_at AV114755 RIKEN cDNA 2610036L13 gene2499 0.09795 1.90 down Mm.23335 Yme1l1 104535_at AF090430 YME1-like 1 (S. cerevisiae)2500 0.09801 1.89 up Mm.21289 Rps12 162317_r_at AV064697 ribosomal protein S122501 0.09809 1.55 down Mm.6926 AI852726 93467_at AI852734 expressed sequence AI8527262502 0.09825 10.07 down Mm.24663 Angl 95228_f_at U72672 angiogenin-like2503 0.09826 1.89 up Mm.25035 C79468 95984_at AI586160 expressed sequence C794682504 0.09834 2.31 up Mm.22673 Fcer1g 160692_at J05020 Fc receptor, IgE, high affinity I, gamma polypeptide2505 0.09847 1.30 down Mm.197518 Laptm4b 100571_at AW123934 lysosomal-associated protein transmembrane 4B2506 0.09863 2.63 up Mm.906 Mdk 160561_at M34094 midkine2507 0.09868 2.19 up Mm.44249 Nos1 98365_at D14552 nitric oxide synthase 1, neuronal2508 0.09868 1.30 down Mm.18494 Map2k3 93315_at AI852636 mitogen activated protein kinase kinase 32509 0.09876 2.41 up Mm.5001 Dnmt3a 100479_at AA756653 DNA methyltransferase 3A2510 0.09889 1.48 up Mm.195916 D18Wsu154e 161990_f_at AV238605 DNA segment, Chr 18, Wayne State University 154, expressed2511 0.09892 1.37 down Mm.144420 0610038P07Rik 96007_at AI835359 RIKEN cDNA 0610038P07 gene2512 0.09898 1.30 down Mm.43822 Cs 99666_at AW125431 citrate synthase2513 0.09899 1.83 up Mm.3941 Eif4e 99097_at M61731 eukaryotic translation initiation factor 4E2514 0.09909 1.64 down Mm.1104 Ube1x 92616_at D10576 ubiquitin-activating enzyme E1, Chr X2515 0.09913 3.01 down Mm.8245 Timp 162107_r_at AV363716 tissue inhibitor of metalloproteinase2516 0.09917 1.71 up Mm.3095 Nr1h4 97969_at U09416 nuclear receptor subfamily 1, group H, member 42517 0.09921 1.76 up Mm.1813 Cct5 161514_at AV170770 chaperonin subunit 5 (epsilon)2518 0.09929 3.56 up Mm.29357 1300017C10Rik 162401_f_at AV278137 RIKEN cDNA 1300017C10 gene2519 0.09941 2.08 up Mm.4545 Tbxa2r 92685_at D10849 thromboxane A2 receptor2520 0.09952 2.34 up Mm.203935 D16Bwg1543e 104055_at AI153645 DNA segment, Chr 16, Brigham & Women's Genetics 1543 expressedPage 28 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description2521 0.09967 2.04 up Mm.8540 1700062C23Rik 101520_at AF032967 RIKEN cDNA 1700062C23 gene2522 0.09969 2.73 up Mm.5244 Crem 160526_s_at M60285 cAMP responsive element modulator2523 0.09971 1.72 down Mm.5128 Htf9c 100525_at X05830 HpaII tiny fragments locus 9c2524 0.09977 3.41 up Mm.5266 Fcer1a 101209_at J05018 Fc receptor, IgE, high affinity I, alpha polypeptide2525 0.09980 1.88 up Mm.2981 Vrk1 97393_at AF080253 vaccinia related kinase 12526 0.09981 1.48 down Mm.8940 Acvr2b 93903_at M84120 activin receptor IIB2527 0.09986 1.52 down Mm.28790 Cpsf3 96234_at AI849311 cleavage and polyadenylation specificity factor 32528 0.09986 1.88 up Mm.19039 Got1 93489_at X07302 glutamate oxaloacetate transaminase 1, soluble2529 0.09995 1.22 down Mm.197493 1300003F06Rik 99636_at AI848033 RIKEN cDNA 1300003F06 gene2530 0.10008 2.04 up Mm.8249 Stat1 101465_at U06924 signal transducer and activator of transcription 12531 0.10019 1.55 up Mm.154979 Plac1 104201_at AA718649 placental specific protein 12532 0.10029 4.09 up Mm.4912 Fgfr4 92937_at X59927 fibroblast growth factor receptor 42533 0.10032 1.67 up Mm.34869 Ndufa1 92330_r_at AA517665 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12534 0.10034 1.29 down Mm.4261 Kai1 99584_at D14883 kangai 1 (suppression of tumorigenicity 6, prostate)2535 0.10041 3.37 up Mm.3807 Mm.3807 97708_at AA438122 ESTs, Weakly similar to I49130 reverse transcriptase - mouse [M.musculus]2536 0.10041 3.16 up Mm.24608 Fbxl12 161098_at AA930049 f-box and leucine-rich repeat protein 122537 0.10049 1.34 down Mm.58771 Rab14 97301_at AW124187 RAB14, member RAS oncogene family2538 0.10049 1.50 down Mm.27061 0610011I04Rik 96605_at AI787183 RIKEN cDNA 0610011I04 gene2539 0.10053 2.08 up Mm.212146 Mm.212146 97645_f_at AA420397 ESTs2540 0.10057 3.84 up Mm.196054 Klra3 93894_f_at U49866 killer cell lectin-like receptor, subfamily A, member 32541 0.10073 1.66 up Mm.30246 Cd151 161823_r_at AV379735 CD151 antigen2542 0.10073 2.16 up Mm.23869 2510006M18Rik 161891_r_at AV372372 RIKEN cDNA 2510006M18 gene2543 0.10082 4.39 up Mm.189064 Mm.189064 161362_at AV215734 EST2544 0.10094 1.46 up Mm.179650 Prkcabp 161638_f_at AV056986 protein kinase C, alpha binding protein2545 0.10094 2.39 up Mm.34216 Ulk1 92209_at AF053756 Unc-51 like kinase 1 (C. elegans)2546 0.10095 1.87 up Mm.88837 Chrna6 96996_at AJ245706 cholinergic receptor, nicotinic, alpha polypeptide 62547 0.10100 1.75 up Mm.3797 Nap1l1 98587_at X61449 nucleosome assembly protein 1-like 12548 0.10107 1.41 up Mm.214 1110007H17Rik 103439_at AW045417 RIKEN cDNA 1110007H17 gene2549 0.10111 2.84 up Mm.9500 Zpbp 161922_r_at AV140661 zona pellucida binding protein2550 0.10121 1.85 up Mm.42829 Sepw1 99595_at AF015284 selenoprotein W, muscle 12551 0.10129 1.47 down Mm.180290 1500032L24Rik 95076_at AI848476 RIKEN cDNA 1500032L24 gene2552 0.10141 3.06 up Mm.2044 Serpinf1 93574_at AF036164 serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigme2553 0.10142 1.56 down Mm.206206 Ncdn-pending 99633_at AB017608 neurochondrin2554 0.10146 1.57 down Mm.33815 Mm.33815 97554_at AI838889 Mus musculus, Similar to hepatocellular carcinoma-associated antigen 59, c2555 0.10151 2.18 up Mm.157783 AI893585 101321_r_at L28059 expressed sequence AI8935852556 0.10153 1.59 down Mm.9945 2610024N01Rik 102199_at AW047322 RIKEN cDNA 2610024N01 gene2557 0.10156 2.34 up Mm.171374 1110032A03Rik 104314_r_at AI851206 RIKEN cDNA 1110032A03 gene2558 0.10163 2.59 up Mm.200916 Ugt1a6 161844_at AV003213 UDP glycosyltransferase 1 family, polypeptide A62559 0.10166 1.59 up Mm.3205 Scyd1 98008_at U92565 small inducible cytokine subfamily D, 12560 0.10180 1.26 down Mm.8392 Bet3-pending 101514_at AF041433 Bet3 homolog (S. cerevisiae)2561 0.10186 2.23 up Mm.1415 Epas1 102698_at AF045160 endothelial PAS domain protein 12562 0.10191 1.29 down Mm.138725 2510001K09Rik 97722_at AA879709 RIKEN cDNA 2510001K09 gene2563 0.10194 1.51 up Mm.5934 Ard1 100575_at AI841645 N-acetyltransferase ARD1 homolog (S. cerevisiae)2564 0.10197 2.50 up Mm.111845 Eln 92836_at AA919594 elastin2565 0.10199 1.70 up Mm.156895 1110020E07Rik 162269_at AV363431 RIKEN cDNA 1110020E07 gene2566 0.10203 1.31 down Mm.21444 1110003H09Rik 93805_at AW121164 RIKEN cDNA 1110003H09 gene2567 0.10205 2.90 up Mm.902 Mm.902 101912_at AI019679 ESTs2568 0.10224 1.36 down Mm.179189 2410038A03Rik 102098_at AI415065 RIKEN cDNA 2410038A03 gene2569 0.10224 1.61 down Mm.4860 Ptprl 100454_at D88187 protein tyrosine phosphatase, receptor type, L2570 0.10226 2.09 up Mm.41189 Freq 92416_at AF020184 frequenin homolog (Drosophila)2571 0.10230 1.87 up Mm.4414 Cdc2l2 161457_at AV297156 cell division cycle 2 homolog (S. pombe)-like 22572 0.10245 1.47 down Mm.28765 1810049E02Rik 160936_at AA763937 RIKEN cDNA 1810049E02 gene2573 0.10245 2.03 up Mm.21776 Cnn2 94004_at Z19543 calponin 22574 0.10247 1.88 up Mm.89474 Cd80 93906_s_at D16220 CD80 antigen2575 0.10251 3.51 up Mm.200437 AA408156 100745_r_at AA408156 expressed sequence AA4081562576 0.10264 2.07 up Mm.5281 Rps7 101212_at AF043285 ribosomal protein S72577 0.10275 1.73 up Mm.4845 Tcfap2a 92923_g_at U17291 transcription factor AP-2, alpha2578 0.10278 3.15 up Mm.37491 C77405 101691_s_at C77405 expressed sequence C774052579 0.10296 2.10 up Mm.30290 Capn6 97942_g_at Y12582 calpain 62580 0.10301 3.74 up Mm.24660 2610528A11Rik 104737_at AA689670 RIKEN cDNA 2610528A11 gene2581 0.10304 1.50 up Mm.36088 Gtf2e2 98515_at AI844392 general transcription factor IIE, polypeptide 2 (beta subunit, 34kD)2582 0.10304 1.64 up Mm.218576 1700009P03Rik 160600_at AA608168 RIKEN cDNA 1700009P03 gene2583 0.10305 1.70 up Mm.194 Flt3 95295_s_at X59398 FMS-like tyrosine kinase 32584 0.10310 3.57 up 95281_at AA5896232585 0.10319 2.63 up Mm.1892 Crhr 95290_at X72305 corticotropin releasing hormone receptor2586 0.10321 1.80 down Mm.14286 U2af1-rs1 102817_at S69507 U2 small nuclear ribonucleoprotein auxiliary factor (U2AF), 35 kDa, related s2587 0.10323 2.15 up Mm.4375 Smstr2 98352_r_at AF008914 somatostatin receptor 22588 0.10328 2.24 up Mm.1251 Mag 102405_at M31811 myelin-associated glycoprotein2589 0.10331 2.16 up Mm.1940 Csf2rb2 103210_at M29855 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macroph2590 0.10335 4.66 up Mm.195085 Tyms-ps 100396_i_at M30774 thymidylate synthase, pseudogene2591 0.10335 2.08 up Mm.196558 Selenbp2 162030_r_at AV366872 selenium binding protein 22592 0.10338 1.78 up Mm.30198 2810025O06Rik 96946_at AW123507 RIKEN cDNA 2810025O06 gene2593 0.10344 1.77 up Mm.27673 D6Wsu176e 97771_r_at AA733372 DNA segment, Chr 6, Wayne State University 176, expressed2594 0.10345 1.52 up Mm.42578 Rpl13 102109_at U28917 ribosomal protein L132595 0.10347 1.48 down Mm.28793 Snap25bp 160792_at AI853318 synaptosomal-associated protein, 25 kDa, binding protein2596 0.10348 3.84 up Mm.203896 Lman1 161622_f_at AV356315 lectin, mannose-binding, 12597 0.10349 1.33 down Mm.22593 Gtf2i 94295_at AF017085 general transcription factor II I2598 0.10352 2.99 up Mm.98916 Vip 100393_at X74297 vasoactive in<strong>test</strong>inal polypeptide2599 0.10354 1.57 up Mm.28618 2410004D02Rik 98916_at AI854289 RIKEN cDNA 2410004D02 gene2600 0.10355 1.52 down Mm.29213 1200015F23Rik 95078_at AI841400 RIKEN cDNA 1200015F23 gene2601 0.10360 1.36 down Mm.18561 Cyhr1 104209_at AI847016 cysteine and histidine rich 12602 0.10365 1.90 up Mm.22216 Gilz 94212_at AI843911 glucocorticoid-induced leucine zipper2603 0.10366 2.57 up Mm.878 Ly6d 162216_i_at AV089967 lymphocyte antigen 6 complex, locus D2604 0.10371 1.33 down Mm.29821 Prdx3 96256_at M28723 peroxiredoxin 32605 0.10373 3.15 up Mm.25097 4930579C15Rik 160985_at AV279590 RIKEN cDNA 4930579C15 gene2606 0.10385 1.97 up Mm.196216 D6Ertd746e 104168_at AA791742 DNA segment, Chr 6, ERATO Doi 746, expressed2607 0.10407 1.36 down Mm.57192 Cyp21a1 97428_at AF049850 cytochrome P450, 21, steroid 21 hydroxylase2608 0.10408 1.39 up Mm.22514 0610008F14Rik 162343_f_at AV149071 RIKEN cDNA 0610008F14 gene2609 0.10422 1.37 down Mm.154985 PAL31 96891_at AI842771 proliferation related acidic leucine rich protein PAL312610 0.10425 2.10 up Mm.2992 Mbp 96311_at M11533 myelin basic proteinPage 29 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description3241 0.13844 2.74 up Mm.41842 Cacna1a 100337_at L29346 calcium channel, voltage-dependent, P/Q type, alpha 1A3242 0.13844 1.27 down Mm.30245 2310047I15Rik 97448_at AI845165 RIKEN cDNA 2310047I15 gene3243 0.13850 1.55 down Mm.28039 1810030E18Rik 97296_at AW124918 RIKEN cDNA 1810030E18 gene3244 0.13865 1.81 up Mm.23869 2510006M18Rik 104566_at AI845009 RIKEN cDNA 2510006M18 gene3245 0.13870 1.27 down Mm.24786 D1Ertd654e 101914_at AI846484 DNA segment, Chr 1, ERATO Doi 654, expressed3246 0.13871 1.35 up Mm.183016 Tdg 101540_at AF069519 thymine DNA glycosylase3247 0.13898 1.57 up Mm.27964 2010110I09Rik 160258_at AI853190 RIKEN cDNA 2010110I09 gene3248 0.13909 1.49 up Mm.2859 Baat 104273_at U95215 bile acid-Coenzyme A: amino acid N-acyltransferase3249 0.13912 3.14 up Mm.12907 Cox7a1 102749_at AF037370 cytochrome c oxidase, subunit VIIa 13250 0.13940 1.56 down Mm.19133 Aplp2 93498_s_at M97216 amyloid beta (A4) precursor-like protein 23251 0.13942 2.89 up Mm.42017 Neurog2 97792_at Y07621 neurogenin 23252 0.13946 1.70 up Mm.12872 Itgb2l 94171_at AF051367 integrin beta 2-like3253 0.13950 3.66 up Mm.9086 Slc16a1 101588_at AF058055 solute carrier family 16 (monocarboxylic acid transporters), member 13254 0.13967 1.70 down Mm.127171 Bfsp1 100390_s_at AB003147 beaded filament structural protein in lens-CP943255 0.13976 3.46 up 160143_r_at Y084863256 0.13990 1.23 down Mm.42197 Psmb1 98113_at U60824 proteasome (prosome, macropain) subunit, beta type 13257 0.13996 1.35 down Mm.27443 D10Wsu93e 104187_at AI847110 DNA segment, Chr 10, Wayne State University 93, expressed3258 0.13998 2.73 up Mm.206794 Mcpt9 94735_s_at M57401 mast cell protease 93259 0.14003 1.59 down Mm.3820 Cmas 98593_at AJ006215 cytidine monophospho-N-acetylneuraminic acid synthetase3260 0.14013 4.90 up Mm.214981 Hist1 94638_at U62675 histone gene complex 13261 0.14015 1.96 up Mm.6456 Pftk1 93421_at AF033655 PFTAIRE protein kinase 13262 0.14033 1.42 up Mm.90115 Lypla1 161774_f_at AV358770 lysophospholipase 13263 0.14038 2.04 up Mm.8186 Klrd1 93677_at AF030311 killer cell lectin-like receptor, subfamily D, member 13264 0.14041 1.50 down Mm.46224 Mm.46224 93169_at AW212708 Mus musculus, clone IMAGE:4503739, mRNA, partial cds3265 0.14042 4.69 up Mm.175310 H2-Aa 92866_at X52643 histocompatibility 2, class II antigen A, alpha3266 0.14044 1.50 up Mm.22575 Maged2 94289_r_at AI851574 melanoma antigen, family D, 23267 0.14046 1.94 up Mm.584 Anxa2 100569_at M14044 annexin A23268 0.14049 1.66 up Mm.667 Gstm5 100631_r_at AA241764 glutathione S-transferase, mu 53269 0.14054 3.62 up Mm.3317 Gus-s 162128_i_at AV376939 beta-glucuronidase structural3270 0.14070 1.58 down Mm.1410 Il18 102802_at D49949 interleukin 183271 0.14077 3.64 up Mm.1858 Cd8a 102975_at U34881 CD8 antigen, alpha chain3272 0.14089 1.58 down Mm.20794 Anxa7 93587_at L13129 annexin A73273 0.14096 1.58 down Mm.193088 Clcn4-2 99672_at Z49916 chloride channel 4-23274 0.14099 2.75 up Mm.3275 Map3k8 161768_r_at AV341985 mitogen activated protein kinase kinase kinase 83275 0.14102 4.11 up Mm.8037 Camk2a 93660_at X87142 calcium/calmodulin-dependent protein kinase II alpha3276 0.14110 2.70 down Mm.56941 Olfr15 102168_at AL078630 olfactory receptor 153277 0.14122 1.65 up Mm.7141 Pcna 101065_at X57800 proliferating cell nuclear antigen3278 0.14122 1.88 up Mm.27997 Rfc5 104001_at AA959940 replication factor C (activator 1) 5 (36.5 kDa)3279 0.14126 1.51 up Mm.20354 Klc1 93565_at AF055665 kinesin light chain 13280 0.14129 2.03 down Mm.28994 Mm.28994 96759_r_at AW061265 Mus musculus, clone MGC:6302 IMAGE:2655022, mRNA, complete cds3281 0.14133 2.55 up Mm.156919 Ctsz 92633_at AJ242663 cathepsin Z3282 0.14133 2.27 up Mm.1715 Ltb 102940_at U16985 lymphotoxin B3283 0.14154 1.42 up 101165_at W917623284 0.14165 1.61 down Mm.28088 Mvk 95632_f_at AW122653 mevalonate kinase3285 0.14172 3.46 up Mm.5255 Slc7a1 101208_at M26687 solute carrier family 7 (cationic amino acid transporter, y+ system), member3286 0.14190 2.59 up Mm.30435 Tsc2 97952_at U39818 tuberous sclerosis 23287 0.14193 1.99 up Mm.19987 Dct 103597_at X63349 dopachrome tautomerase3288 0.14203 2.09 up Mm.821 Snrpa1 161929_at AV170107 U2 small nuclear ribonucleoprotein polypeptide A'3289 0.14205 2.64 up Mm.4421 Tph 161385_r_at AV250738 tryptophan hydroxylase3290 0.14212 1.80 up Mm.29755 Incenp 93758_at AA823653 inner centromere protein3291 0.14213 1.38 down Mm.5856 Nyren18-pending 100570_at U27462 NY-REN-18 antigen3292 0.14214 1.60 up Mm.57247 Apc2 102582_at AJ130783 adenomatosis polyposis coli 23293 0.14217 2.22 up Mm.4778 Cspg3 98798_at X84727 chondroitin sulfate proteoglycan 33294 0.14217 1.37 down Mm.12915 Nit1 160075_at AF069988 nitrilase 13295 0.14225 1.45 down Mm.18706 AA414968 93339_at AI846243 expressed sequence AA4149683296 0.14226 1.29 up Mm.1776 Fth 161913_r_at AV378014 ferritin heavy chain3297 0.14231 2.75 up Mm.154660 Plat 93981_at J03520 plasminogen activator, tissue3298 0.14241 1.28 up Mm.142095 1200011K09Rik 96884_at AI847631 RIKEN cDNA 1200011K09 gene3299 0.14247 1.54 down Mm.15185 Madh1 102984_g_at U58992 MAD homolog 1 (Drosophila)3300 0.14251 1.48 down Mm.144337 1110059H15Rik 95031_at AW060212 RIKEN cDNA 1110059H15 gene3301 0.14257 3.21 up Mm.2719 Zic1 104169_at D32167 zinc finger protein of the cerebellum 13302 0.14260 1.32 down Mm.3931 Max 99095_at M63903 Max protein3303 0.14268 3.23 down Mm.22682 Pip5k2c 161763_r_at AV303514 phosphatidylinositol-4-phosphate 5-kinase, type II, gamma3304 0.14269 1.22 down Mm.4597 Pctk1 100093_at X69025 PCTAIRE-motif protein kinase 13305 0.14270 2.35 up Mm.4078 Mki67 161931_r_at AV309347 antigen identified by monoclonal antibody Ki 673306 0.14270 3.97 up Mm.32207 Wnt5a 99390_at M89798 wingless-related MMTV integration site 5A3307 0.14278 1.88 up Mm.4829 Etsrp71 101150_at L10427 ets related protein 713308 0.14281 2.07 up Mm.143742 Aig1-pending 103543_at AW208098 acupuncture induced gene 13309 0.14281 1.50 down Mm.24782 Naf1-pending 104755_at AJ242778 Nef-associated factor 13310 0.14291 2.08 up Mm.6898 Birc1a 93461_at AF007769 baculoviral IAP repeat-containing 1a3311 0.14300 1.37 up Mm.23990 AW558298 95886_g_at AA177826 expressed sequence AW5582983312 0.14301 1.65 down Mm.197555 MGC6664 101485_at AW124859 hypothetical protein MGC66643313 0.14301 2.69 up Mm.18658 Adcy7 103392_at U12919 adenylate cyclase 73314 0.14302 2.00 down Mm.3626 2600001J17Rik 160845_at AW214617 RIKEN cDNA 2600001J17 gene3315 0.14304 1.91 up Mm.58 Itgb7 100906_at M68903 integrin beta 73316 0.14304 3.71 up Mm.663 Odf2 100626_at AF034105 outer dense fiber of sperm tails 23317 0.14305 2.94 up Mm.779 Cd5 93637_at M15177 CD5 antigen3318 0.14307 1.51 up Mm.29383 Mm.29383 160804_at AI836524 ESTs, Highly similar to E2BE RAT TRANSLATION INITIATION FACTOR EIF3319 0.14310 2.02 up Mm.2856 Il6ra 104268_at X51975 interleukin 6 receptor, alpha3320 0.14313 1.63 down Mm.29910 Rps6ka1 161419_r_at AV321321 ribosomal protein S6 kinase polypeptide 13321 0.14315 1.26 up Mm.44225 Mrpl17 100040_at AI843081 mitochondrial ribosomal protein L173322 0.14319 1.75 up Mm.24313 Mm.24313 103732_at AI850079 ESTs, Moderately similar to similar to phosphatidylinositol [H.sapiens]3323 0.14330 1.27 up Mm.28470 0910001B06Rik 97907_at AW049564 RIKEN cDNA 0910001B06 gene3324 0.14359 1.81 up Mm.982 Edg1 161788_f_at AV347228 endothelial differentiation sphingolipid G-protein-coupled receptor 13325 0.14361 1.42 up Mm.30150 1010001M12Rik 102097_f_at AI323980 RIKEN cDNA 1010001M12 gene3326 0.14362 2.43 up Mm.1202 Myb 92644_s_at M12848 myeloblastosis oncogene3327 0.14365 2.38 up Mm.88645 Tes 101550_at X78990 <strong>test</strong>is derived transcript3328 0.14377 1.25 down Mm.21149 Cript-pending 93760_at AI838759 postsynaptic protein Cript3329 0.14387 2.08 up Mm.1682 Ptpns1 95804_g_at D85785 protein tyrosine phosphatase, non-receptor type substrate 13330 0.14388 1.69 up Mm.30805 AI463083 104508_at AA756506 expressed sequence AI463083Page 37 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description3511 0.15566 1.84 up Mm.25145 AI847581 96490_at AI847581 expressed sequence AI8475813512 0.15570 1.43 down Mm.6775 Oazi 101002_at AF032128 ornithine decarboxylase antizyme inhibitor3513 0.15579 1.38 down Mm.426 Gstp2 99583_at X53451 glutathione S-transferase, pi 23514 0.15584 1.83 up Mm.27402 2010001P08Rik 162205_f_at AV374357 RIKEN cDNA 2010001P08 gene3515 0.15585 1.77 up Mm.24507 Mm.24507 95164_at AA409213 ESTs3516 0.15585 1.30 down Mm.18946 Ap2m1 93362_at U27106 adaptor protein complex AP-2, mu13517 0.15591 1.63 down Mm.18113 3110038K10Rik 103338_at AW120504 RIKEN cDNA 3110038K10 gene3518 0.15598 1.54 up Mm.29409 4933428G09Rik 104446_f_at AI595812 RIKEN cDNA 4933428G09 gene3519 0.15601 2.53 up Mm.2821 6530401N04Rik 104243_r_at AI835622 RIKEN cDNA 6530401N04 gene3520 0.15601 1.87 up Mm.4641 Tff3 100106_at D38410 trefoil factor 3, in<strong>test</strong>inal3521 0.15608 3.05 up Mm.5058 Cadps 92989_f_at D86214 Cadependent activator protein for secretion3522 0.15619 2.65 up Mm.4128 Axl 99136_at X63535 AXL receptor tyrosine kinase3523 0.15629 1.99 up Mm.3645 Myo5a 98968_at X57377 myosin Va3524 0.15631 2.09 up 102932_at M813853525 0.15633 1.93 up Mm.27529 D7Ertd348e 95032_at AA856349 DNA segment, Chr 7, ERATO Doi 348, expressed3526 0.15639 1.42 down Mm.8294 Vbp1 101509_at U96760 von Hippel-Lindau binding protein 13527 0.15644 3.16 up Mm.4836 Sgne1 100131_at X15830 secretory granule neuroendocrine protein 1, 7B2 protein3528 0.15646 2.31 down Mm.28774 Mm.28774 96230_at AA790936 ESTs3529 0.15651 2.97 up Mm.87839 Zfy1 98343_s_at AF074549 zinc finger protein 1, Y linked3530 0.15667 1.35 down Mm.200982 AA410023 97551_at AI846182 expressed sequence AA4100233531 0.15669 1.83 up Mm.2338 Glns 99498_at M60803 glutamine synthetase3532 0.15673 1.89 up Mm.8048 H1f3 100280_at X72805 H1 histone family, member 33533 0.15674 2.34 up Mm.23704 Fosl2 103546_at X83971 fos-like antigen 23534 0.15676 1.65 down Mm.2135 Folr1 93785_at M64782 folate receptor 1 (adult)3535 0.15681 2.32 up Mm.7861 Hnrpdl 161372_f_at AV240182 heterogeneous nuclear ribonucleoprotein D-like3536 0.15699 4.78 up Mm.1365 Tyr 102666_at M26729 tyrosinase3537 0.15709 1.44 down Mm.18522 Cpt1a 93320_at AF017175 carnitine palmitoyltransferase 1, liver3538 0.15712 2.56 up Mm.22126 Fabp1 162342_at AV139831 fatty acid binding protein 1, liver3539 0.15733 1.82 down Mm.7800 Itpr5 101442_f_at AF031127 inositol 1,4,5-triphosphate receptor 53540 0.15735 2.13 up Mm.35851 Sap18 161303_at AV054196 Sin3-associated polypeptide 183541 0.15735 1.53 up Mm.34289 H2-Bl 101300_at M26156 histocompatibility 2, blastocyst3542 0.15740 1.29 up Mm.873 Snrp116-pending 101530_at U97079 U5 small nuclear ribonucleoprotein 116 kDa3543 0.15745 2.36 up Mm.17031 Pou5f1 103075_at M34381 POU domain, class 5, transcription factor 13544 0.15752 2.38 up Mm.2523 Myt1l 96497_s_at AI848062 myelin transcription factor 1-like3545 0.15752 1.26 down Mm.1838 Vamp8 93305_f_at AF053724 vesicle-associated membrane protein 83546 0.15758 1.62 up Mm.30020 C77652 160378_at AI853127 expressed sequence C776523547 0.15769 5.65 up Mm.10747 Aif1 102330_at D86382 allograft inflammatory factor 13548 0.15771 1.31 down Mm.5710 2610017J04Rik 93217_at AW049642 RIKEN cDNA 2610017J04 gene3549 0.15781 1.62 up Mm.30282 Ebf3 104492_at U92702 early B-cell factor 33550 0.15782 3.79 up Mm.15528 Pcdha4 160610_at D86916 protocadherin alpha 43551 0.15787 2.17 up Mm.4394 Kit 99956_at Y00864 kit oncogene3552 0.15788 2.90 up Mm.10826 Umod 92605_at L33406 uromodulin3553 0.15793 1.78 up Mm.10693 Sprr2h 94121_at AJ005566 small proline-rich protein 2H3554 0.15795 2.00 down Mm.21712 AW558171 93985_at AW120868 expressed sequence AW5581713555 0.15796 1.86 up Mm.45765 2810417H13Rik 100116_at AI122538 RIKEN cDNA 2810417H13 gene3556 0.15797 3.17 up Mm.10760 Osmr 102255_at AB015978 oncostatin receptor3557 0.15801 1.49 down Mm.11360 AU018154 102352_at AW121380 expressed sequence AU0181543558 0.15801 1.51 down Mm.204698 Mm.204698 97400_at AW122420 Mus musculus, clone MGC:37879 IMAGE:5101205, mRNA, complete cds3559 0.15804 5.02 up Mm.3771 Ptprr 162209_r_at AV378081 protein tyrosine phosphatase, receptor type, R3560 0.15809 3.04 up Mm.57069 LOC56544 101742_at AF053986 tissue-type vomeronasal neurons putative pheromone receptor V2R23561 0.15821 1.36 down Mm.18892 Emd 103420_at U79753 emerin3562 0.15821 1.32 down Mm.24772 Mmrp19-pending 104752_at AB028863 monocyte macrophage 193563 0.15823 1.58 down Mm.1405 Wbp2 92863_at U40826 WW domain binding protein 23564 0.15827 2.85 up Mm.26791 Gnrhr 104013_at L28757 gonadotropin releasing hormone receptor3565 0.15846 1.53 up Mm.10124 Chkl 102026_s_at AB011000 choline kinase-like3566 0.15848 1.26 down Mm.6505 Sptlc1 100608_at X95641 serine palmitoyltransferase, long chain base subunit 13567 0.15853 1.69 up Mm.24868 Mm.24868 160719_at AW049760 Mus musculus, Similar to CGI-147 protein, clone MGC:25743 IMAGE:399003568 0.15859 1.40 down Mm.30071 Laptm4a 96876_at U34259 lysosomal-associated protein transmembrane 4A3569 0.15873 1.45 up Mm.3135 Igfals 97987_at U66900 insulin-like growth factor binding protein, acid labile subunit3570 0.15887 1.79 down Mm.3979 Mm.3979 104019_at AI851068 Mus musculus, Similar to ubiquitin-like 4, clone MGC:19132 IMAGE:42156993571 0.15889 1.33 up Mm.45151 1700043E15Rik 98077_at AA796831 RIKEN cDNA 1700043E15 gene3572 0.15911 1.93 up Mm.21789 1200014D15Rik 104086_at AI787269 RIKEN cDNA 1200014D15 gene3573 0.15920 1.57 down Mm.2862 5730414C17Rik 98917_at AA823202 RIKEN cDNA 5730414C17 gene3574 0.15921 1.26 up Mm.178550 2410026K10Rik 101047_at AW123697 RIKEN cDNA 2410026K10 gene3575 0.15924 2.23 up Mm.278 Guca2b 95569_at U95182 guanylate cyclase activator 2b (retina)3576 0.15925 1.64 down Mm.1532 Mm.1532 162049_f_at AV379304 Mus musculus, clone MGC:31332 IMAGE:4224574, mRNA, complete cds3577 0.15926 1.62 down Mm.201095 C76432 99597_at AI841629 expressed sequence C764323578 0.15927 5.71 up Mm.197 Hoxa1 95297_at M22115 homeo box A13579 0.15933 2.47 up Mm.16148 Musk 94763_at U37709 muscle, skeletal, receptor tyrosine kinase3580 0.15934 1.45 down 96949_at AI8535423581 0.15959 1.65 up Mm.1685 Plxn3 102933_at D86950 plexin 33582 0.15961 2.76 up Mm.59652 Mm.59652 94792_at AI447305 ESTs3583 0.15964 2.05 up Mm.45025 6330409N04Rik 161055_r_at AW047521 RIKEN cDNA 6330409N04 gene3584 0.15967 3.00 up Mm.2608 Bgn 96049_at X53928 biglycan3585 0.15971 1.47 up Mm.88847 Olfr70 97005_at AJ133430 olfactory receptor 703586 0.15976 2.64 up Mm.24169 Cebpa-rs1 94467_at U19892 CCAAT/enhancer binding protein alpha (C/EBP), related sequence 13587 0.15981 1.38 down Mm.28237 AU041521 160277_at AW125618 expressed sequence AU0415213588 0.16004 1.88 up Mm.88850 Zirtl 100373_at AJ243651 zinc-iron transporter-like3589 0.16007 2.23 up Mm.103336 Rara 92901_at M60909 retinoic acid receptor, alpha3590 0.16009 1.59 down Mm.24105 Nude-pending 94910_at AW120739 nuclear distribution gene E homolog (Aspergillus)3591 0.16011 2.75 up Mm.2381 Aplp1 94874_at L04538 amyloid beta (A4) precursor-like protein 13592 0.16035 1.41 down Mm.22485 2610311I19Rik 94273_at AI849067 RIKEN cDNA 2610311I19 gene3593 0.16036 2.14 up Mm.1791 Dusp6 93285_at AI845584 dual specificity phosphatase 63594 0.16042 1.60 down Mm.5242 2900086B20Rik 161057_at AI662504 RIKEN cDNA 2900086B20 gene3595 0.16043 1.69 up Mm.27681 Adam17 160241_at AB021709 a disintegrin and metalloproteinase domain 173596 0.16046 2.88 up Mm.202775 2610007A16Rik 162367_f_at AV233977 RIKEN cDNA 2610007A16 gene3597 0.16050 1.24 down Mm.28145 2700061N24Rik 104237_at AI838071 RIKEN cDNA 2700061N24 gene3598 0.16060 1.32 up Mm.2209 Cd4 98147_at AC002397 CD4 antigen3599 0.16063 4.13 up Mm.93201 Mm.93201 161764_r_at AV334462 ESTs3600 0.16084 1.37 down Mm.21773 Mm.21773 94003_at AI848510 ESTs, Highly similar to AF227741 1 protein kinase WNK1 [R.norvegicus]Page 40 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description3601 0.16099 5.31 up Mm.1120 Ebaf 162480_f_at AV101751 endometrial bleeding associated factor3602 0.16107 1.32 up Mm.3785 Ppp2r5c 98993_at U59418 protein phosphatase 2, regulatory subunit B (B56), gamma isoform3603 0.16115 1.96 up Mm.715 Hck 93483_at J03023 hemopoietic cell kinase3604 0.16116 1.47 up Mm.4702 Gnb5 100122_at L34290 guanine nucleotide binding protein, beta 53605 0.16121 2.61 up Mm.1160 AI597080 161168_at AV237606 expressed sequence AI5970803606 0.16121 1.32 down Mm.155 2610204K14Rik 93059_at AI854841 RIKEN cDNA 2610204K14 gene3607 0.16136 1.38 down Mm.100399 Madh4 160440_at U79748 MAD homolog 4 (Drosophila)3608 0.16157 3.47 up Mm.25788 4633402D15Rik 160992_at AI035432 RIKEN cDNA 4633402D15 gene3609 0.16159 1.29 up Mm.3760 Fasn 98575_at X13135 fatty acid synthase3610 0.16160 1.52 down Mm.30435 Tsc2 97951_s_at U37775 tuberous sclerosis 23611 0.16162 1.73 up Mm.3499 Rax 97149_at U73177 retina and anterior neural fold homeobox3612 0.16168 1.52 up Mm.21545 Tdo2 93827_at U24493 tryptophan 2,3-dioxygenase3613 0.16170 1.45 up Mm.4824 Syt3 92916_at D45858 synaptotagmin 33614 0.16178 2.00 up Mm.263 Reg3g 96064_at D63362 regenerating islet-derived 3 gamma3615 0.16183 2.96 up Mm.157101 C330007P06Rik 103696_r_at AW047329 RIKEN cDNA C330007P06 gene3616 0.16187 2.88 up Mm.25046 Mm.25046 95987_at C80377 ESTs3617 0.16188 1.65 up Mm.1834 Lyn 103349_at M57696 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog3618 0.16205 1.99 up Mm.1302 Sfpi1 102641_at L03215 SFFV proviral integration 13619 0.16247 1.54 up Mm.14198 Edr2 92867_at AF060076 early development regulator 2 (homolog of polyhomeotic 2)3620 0.16249 2.07 up Mm.29065 0610006N12Rik 94541_at AI839549 RIKEN cDNA 0610006N12 gene3621 0.16255 1.80 up Mm.43612 Ogg1 160882_at AF012916 8-oxoguanine DNA-glycosylase 13622 0.16261 3.03 up Mm.2535 Mata2-pending 96505_at U88401 metastasis associated 23623 0.16263 1.34 up Mm.21184 D2Wsu58e 162311_f_at AV050648 DNA segment, Chr 2, Wayne State University 58, expressed3624 0.16272 1.39 down Mm.2566 Ang 94392_f_at U22516 angiogenin3625 0.16282 1.58 down Mm.88793 Fga 101553_at AI876446 fibrinogen, alpha polypeptide3626 0.16284 1.85 up Mm.3730 Sema3e 96097_at AI847973 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (se3627 0.16288 1.66 up Mm.12860 D0Kist8 102305_at AB016602 DNA segment, KIST 83628 0.16290 1.63 down Mm.9901 Nucb2 102197_at AJ222586 nucleobindin 23629 0.16291 1.16 down Mm.196635 2010005E08Rik 101067_at AW124711 RIKEN cDNA 2010005E08 gene3630 0.16307 1.81 down Mm.29088 0610013D04Rik 96785_at AF110520 RIKEN cDNA 0610013D04 gene3631 0.16307 2.27 up Mm.4421 Tph 99972_at J04758 tryptophan hydroxylase3632 0.16312 1.22 down Mm.18561 Cyhr1 103467_g_at AA790056 cysteine and histidine rich 13633 0.16316 5.94 up Mm.1722 2810012G08Rik 102942_at AA683785 RIKEN cDNA 2810012G08 gene3634 0.16323 1.36 down Mm.30270 Psma4 97459_at AI851441 proteasome (prosome, macropain) subunit, alpha type 43635 0.16331 1.92 up Mm.28280 Renbp 161153_r_at AV211623 renin binding protein3636 0.16334 1.89 down Mm.173818 Mm.173818 102133_at AI158971 ESTs, Weakly similar to ZINC FINGER PROTEIN ZFP-90 [M.musculus]3637 0.16358 1.37 up Mm.90115 Lypla1 101944_at U89352 lysophospholipase 13638 0.16367 1.39 down Mm.196484 Csrp 160065_s_at AI837625 cysteine rich protein3639 0.16380 1.31 up Mm.25785 Ldb2 93682_at U89489 LIM domain binding 23640 0.16387 1.72 up Mm.130322 Paf53-pending 98021_at D14336 RNA polymerase I associated factor, 53 kD3641 0.16402 3.04 up Mm.24301 2310067L16Rik 103730_at AI414756 RIKEN cDNA 2310067L16 gene3642 0.16402 2.87 up Mm.969 Mm.969 93963_at AA200748 ESTs3643 0.16420 3.22 up Mm.104747 Igk-V28 102553_at Z70662 immunoglobulin kappa chain variable 28 (V28)3644 0.16424 3.67 up Mm.22519 5230400M11Rik 104336_at AI843273 RIKEN cDNA 5230400M11 gene3645 0.16424 1.31 down Mm.29398 D19Wsu162e 96829_at AW047083 DNA segment, Chr 19, Wayne State University 162, expressed3646 0.16437 7.03 up Mm.34927 Mm.34927 97135_at C76313 ESTs3647 0.16438 2.80 up Mm.18921 Vcp 161550_r_at AV246219 valosin containing protein3648 0.16445 1.88 up Mm.28483 D530048A03Rik 95883_at AW048355 RIKEN cDNA D530048A03 gene3649 0.16451 1.84 up Mm.218862 Mm.218862 101532_g_at AI527354 Mus musculus, clone MGC:25455 IMAGE:4241025, mRNA, complete cds3650 0.16462 1.88 up Mm.5398 Mm.5398 97598_at AW209139 EST3651 0.16480 1.45 down Mm.215 Hoxb6 103445_at M18401 homeo box B63652 0.16481 2.75 up Mm.18 1-Sep 102962_at M37030 septin 13653 0.16484 2.90 up Mm.140155 Tlbp 94927_at U96149 <strong>test</strong>is lipid binding protein3654 0.16484 3.06 up Mm.4784 Gad2 92899_at D42051 glutamic acid decarboxylase 23655 0.16501 1.74 down Mm.4040 Myo6 92382_at U49739 myosin VI3656 0.16504 1.53 up 101445_at AF0360083657 0.16505 1.52 up Mm.5510 Mm.5510 93187_at AW048347 Mus musculus, Similar to gene overexpressed in astrocytoma, clone IMAGE3658 0.16508 1.39 down Mm.197479 Foxp1 96183_at AW122985 forkhead box P13659 0.16511 1.62 up Mm.3929 Zfhx1a 99052_at D76432 zinc finger homeobox 1a3660 0.16521 1.66 up Mm.203041 AW215585 102920_at AW215585 expressed sequence AW2155853661 0.16526 1.24 up Mm.871 Rfng 101858_at AF015770 radical fringe gene homolog, (Drosophila)3662 0.16553 1.69 up Mm.180561 Rbpsuh 101902_at X17459 recombining binding protein suppressor of hairless (Drosophila)3663 0.16561 1.92 up Mm.5875 Prss8 100909_at AA760364 protease, serine, 8 (prostasin)3664 0.16566 1.73 down Mm.19353 LOC56304 97563_f_at AF042798 recombinant antineuraminidase single chain Ig VH and VL domains3665 0.16568 1.56 down Mm.10088 Dtnb 102210_at AJ003007 dystrobrevin, beta3666 0.16571 2.17 up Mm.15617 Il11ra1 93065_at U14412 interleukin 11 receptor, alpha chain 13667 0.16578 2.20 up Mm.21458 1810009A16Rik 161314_r_at AV086272 RIKEN cDNA 1810009A16 gene3668 0.16583 1.97 up Mm.20323 5830400A04Rik 103231_at AA739233 RIKEN cDNA 5830400A04 gene3669 0.16594 1.55 down Mm.3766 Ppm1a 98580_at D28117 protein phosphatase 1A, magnesium dependent, alpha isoform3670 0.16597 1.52 down Mm.14352 Sel1h 92870_at AF063095 Sel1 (suppressor of lin-12) 1 homolog (C. elegans)3671 0.16600 1.64 up Mm.37369 1110037N09Rik 160824_at AI852741 RIKEN cDNA 1110037N09 gene3672 0.16605 1.66 up Mm.1291 Tgfb3 102751_at M32745 transforming growth factor, beta 33673 0.16614 2.40 up Mm.3899 Hcngp-pending 161662_f_at AV124076 transcriptional regulator protein3674 0.16615 1.58 down Mm.34790 AA407033 160432_at AI853062 expressed sequence AA4070333675 0.16617 1.31 down Mm.3965 Stam 92360_at U43900 signal transducing adaptor molecule (SH3 domain and ITAM motif) 13676 0.16622 3.04 up Mm.3246 Frzb 104672_at U68058 frizzled-related protein3677 0.16623 1.79 up Mm.16251 Psmb9 93085_at D44456 proteosome (prosome, macropain) subunit, beta type 9 (large multifunctiona3678 0.16625 1.35 down Mm.3126 Fhl1 97500_g_at AI839950 four and a half LIM domains 13679 0.16629 2.13 up Mm.3085 6230425C21Rik 97967_at AA881438 RIKEN cDNA 6230425C21 gene3680 0.16630 1.85 up Mm.27571 1110007C05Rik 95041_at AI846165 RIKEN cDNA 1110007C05 gene3681 0.16634 1.41 down Mm.29186 Dnaja2 95068_at AA763945 DnaJ (Hsp40) homolog, subfamily A, member 23682 0.16638 2.27 up Mm.9277 Pla2g7 101923_at U34277 phospholipase A2 group VII (platelet-activating factor acetylhydrolase, plasm3683 0.16648 2.25 up Mm.46754 AI316867 162233_r_at AV325582 expressed sequence AI3168673684 0.16649 1.86 up Mm.2419 Cdh4 95898_at X69966 cadherin 43685 0.16657 1.55 up Mm.44501 2500002G23Rik 104353_at AW047921 RIKEN cDNA 2500002G23 gene3686 0.16664 1.62 up Mm.28050 Cd2bp2 160766_at AA733868 CD2 antigen (cytoplasmic tail) binding protein 23687 0.16666 1.63 down Mm.3344 2600001M11Rik 104693_at AA260145 RIKEN cDNA 2600001M11 gene3688 0.16679 3.75 up Mm.2185 Bub1 162264_s_at AV359014 budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)3689 0.16690 1.16 down Mm.4896 Rpo2-4 100461_at D85818 RNA polymerase II 4 (14 kDa subunit)3690 0.16697 2.09 up Mm.3514 Gdf8 97155_at U84005 growth differentiation factor 8Page 41 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description3781 0.17224 1.85 up Mm.4902 AA517023 101154_at AA517023 expressed sequence AA5170233782 0.17224 1.30 down Mm.25311 1810015C04Rik 95518_at AW122893 RIKEN cDNA 1810015C04 gene3783 0.17232 1.30 up Mm.27933 Poh1-pending 97274_at Y13071 26S proteasome-associated pad1 homolog3784 0.17234 1.50 down Mm.27074 2610019N13Rik 96609_at AW122195 RIKEN cDNA 2610019N13 gene3785 0.17240 1.55 up Mm.41307 2610014F08Rik 92421_at AI846645 RIKEN cDNA 2610014F08 gene3786 0.17270 1.88 up Mm.87312 Gmfb 101860_at AA756568 glia maturation factor, beta3787 0.17273 2.52 up Mm.135 Cln3 161643_i_at AV076916 ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)3788 0.17277 2.96 up Mm.42226 Matn3 102089_at Y10521 matrilin 33789 0.17287 1.77 up Mm.14418 Tesp2 94741_at AB008911 <strong>test</strong>icular serine protease 23790 0.17288 1.42 up Mm.2240 1110013B16Rik 104312_at AW123271 RIKEN cDNA 1110013B16 gene3791 0.17293 1.63 down Mm.24965 D2Ertd63e 95862_at C77692 DNA segment, Chr 2, ERATO Doi 63, expressed3792 0.17293 1.66 up Mm.25806 AA986477 160212_at AW050205 expressed sequence AA9864773793 0.17294 1.88 up Mm.4745 Ksr 92764_at U43585 kinase suppressor of ras3794 0.17307 1.68 up Mm.21353 Mm.21353 103903_at AW122472 ESTs, Weakly similar to DnaJ (Hsp40) homolog, subfamily B, member 6; ma3795 0.17309 1.60 up Mm.29550 Mm.29550 97335_at AA795198 Mus musculus, clone MGC:36283 IMAGE:4158605, mRNA, complete cds3796 0.17315 1.55 down Mm.18941 1190006E07Rik 160112_at AI852865 RIKEN cDNA 1190006E07 gene3797 0.17316 2.35 up Mm.27857 2410088E07Rik 95584_at AA794108 RIKEN cDNA 2410088E07 gene3798 0.17323 1.90 up Mm.42823 6530413N01Rik 99553_f_at AI842002 RIKEN cDNA 6530413N01 gene3799 0.17325 1.44 down Mm.182232 1110018N24Rik 94868_at AW049812 RIKEN cDNA 1110018N24 gene3800 0.17338 2.46 up Mm.46754 AI316867 161954_r_at AV362664 expressed sequence AI3168673801 0.17338 6.57 up Mm.4482 Col1a2 101130_at X58251 procollagen, type I, alpha 23802 0.17348 1.26 down Mm.22362 H47 94245_at AW125865 histocompatibility 473803 0.17354 2.18 up Mm.9154 Tgfb1 101918_at AJ009862 transforming growth factor, beta 13804 0.17364 1.37 up Mm.3285 3110056O03Rik 98029_at AW060459 RIKEN cDNA 3110056O03 gene3805 0.17377 1.38 up Mm.30266 Hbb-b1 162457_f_at AV003378 hemoglobin, beta adult major chain3806 0.17380 1.42 down Mm.41 Atp5o 99128_at AI849767 ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit3807 0.17382 1.87 up Mm.4139 Rtkn 160864_at U54638 rhotekin3808 0.17384 1.70 up Mm.6251 Tnfrsf11a 101632_at AF019046 tumor necrosis factor receptor superfamily, member 11a3809 0.17387 1.22 down Mm.28202 D16Ertd269e 97823_g_at AW122689 DNA segment, Chr 16, ERATO Doi 269, expressed3810 0.17389 1.90 up Mm.200941 Saa2 103465_f_at U60438 serum amyloid A 23811 0.17390 4.01 up Mm.219554 Pcdha13 101770_i_at AB008180 protocadherin alpha 133812 0.17397 1.83 down Mm.28551 Sudd 161551_f_at AV247682 sudD, suppressor of bimD6 homolog (Aspergillus nidulans)3813 0.17397 2.00 up Mm.27491 Map2k4 99960_at U18310 mitogen activated protein kinase kinase 43814 0.17406 1.52 up Mm.4215 Cas1 160479_at M29394 catalase 13815 0.17410 1.60 down Mm.28626 2410018G23Rik 98920_g_at AA867773 RIKEN cDNA 2410018G23 gene3816 0.17416 2.48 up Mm.30290 Capn6 97941_at Y12582 calpain 63817 0.17428 2.63 up Mm.213198 Mm.213198 99342_at M60596 Mus musculus gamma-aminobutyric acid (GABA-A) receptor, subunit delta (G3818 0.17431 1.44 up Mm.22279 Casp8ap2 104290_at AI847837 caspase 8 associated protein 23819 0.17432 1.41 up Mm.56903 Gpr44 101282_at AF054507 G protein-coupled receptor 443820 0.17435 1.63 up Mm.179747 Itga7 93061_at L23423 integrin alpha 73821 0.17443 1.18 down Mm.27220 Nfyc 94968_at AW048793 nuclear transcription factor-Y gamma3822 0.17444 1.48 down Mm.9248 Adprt1 101957_f_at X14206 ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 13823 0.17444 1.22 down Mm.4222 Tpi 99566_at L31777 triosephosphate isomerase3824 0.17445 1.90 up Mm.19946 S100a5 95301_at AF087469 S100 calcium binding protein A53825 0.17446 1.39 up Mm.29717 Ywhag 95716_at AW125041 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma po3826 0.17454 1.86 up Mm.28050 Cd2bp2 162099_f_at AV360307 CD2 antigen (cytoplasmic tail) binding protein 23827 0.17456 3.43 up Mm.29170 Fbxw5 96798_r_at AW122681 f-box and WD-40 domain protein 53828 0.17464 2.16 up Mm.20424 Fgf18 95316_at AB004639 fibroblast growth factor 183829 0.17477 1.95 up Mm.79266 Mm.79266 162084_i_at AV314213 EST3830 0.17481 1.30 down Mm.21251 Dp1 96115_at U28168 deleted in polyposis 13831 0.17485 1.63 up Mm.156 Dok1 102896_at U78818 downstream of tyrosine kinase 13832 0.17488 1.23 up Mm.23868 Mm.23868 160964_at AI838494 Mus musculus brain cDNA, clone MNCb-41373833 0.17498 1.71 up Mm.17306 Tpm3 93265_at X53753 tropomyosin 3, gamma3834 0.17498 2.21 up Mm.38548 Rgs9 99907_at AF011358 regulator of G-protein signaling 93835 0.17502 1.22 up Mm.21880 Prss25 161446_r_at AV353694 protease, serine, 253836 0.17508 2.37 up Mm.182913 Csnk1d 97264_r_at AI846289 casein kinase 1, delta3837 0.17520 1.73 up Mm.1262 Cyp17 102416_at M64863 cytochrome P450, 173838 0.17524 1.44 down Mm.36769 Slap 98553_at AW124175 sarcolemmal-associated protein3839 0.17526 1.64 up Mm.12967 Ikbkg 94196_at AF069542 inhibitor of kappaB kinase gamma3840 0.17533 2.44 up Mm.1296 Tpx1 92825_at M25533 <strong>test</strong>is specific gene 13841 0.17535 1.33 up Mm.2973 Pkd1 97375_at U70209 polycystic kidney disease 1 homolog3842 0.17541 2.51 up Mm.360 Cox5a 160438_at X15963 cytochrome c oxidase, subunit Va3843 0.17566 2.14 down Mm.27816 Hexb 97232_at U07049 hexosaminidase B3844 0.17570 1.54 down Mm.6259 Slc4a1ap 93396_at AF035526 solute carrier family 4 (anion exchanger), member 1, adaptor protein3845 0.17576 1.86 up Mm.196574 Grhpr 95085_r_at AI844995 glyoxylate reductase/hydroxypyruvate reductase3846 0.17589 1.65 down Mm.2304 AI646383 95382_at AI646383 expressed sequence AI6463833847 0.17593 1.68 up Mm.16898 Phgdh 162168_r_at AV361953 3-phosphoglycerate dehydrogenase3848 0.17593 1.74 up Mm.12809 Gucy2e 98727_at L41933 guanylate cyclase 2e3849 0.17597 1.60 up Mm.24462 AA407619 95913_at AI661057 expressed sequence AA4076193850 0.17599 1.77 up Mm.8029 Sema6b 99911_at AF036585 sema domain, transmembrane domain (TM), and cytoplasmic domain, (sema3851 0.17604 1.64 down Mm.142364 Star 92213_at L36062 steroidogenic acute regulatory protein3852 0.17604 2.21 up Mm.153729 2210010C04Rik 101839_at AE000663 RIKEN cDNA 2210010C04 gene3853 0.17608 2.73 up Mm.4949 Pdx1 98821_at X74342 pancreatic and duodenal homeobox gene 13854 0.17615 2.41 up Mm.79380 Lhx9 93643_at AJ243851 LIM homeobox protein 93855 0.17626 1.27 down Mm.34609 D5Wsu111e 98092_at AA790307 DNA segment, Chr 5, Wayne State University 111, expressed3856 0.17630 1.79 up Mm.5181 Rnf19 161814_f_at AV355427 ring finger protein (C3HC4 type) 193857 0.17635 1.81 up Mm.40323 Mm.40323 160860_at AI853332 Mus musculus, clone IMAGE:4224368, mRNA, partial cds3858 0.17642 2.16 up Mm.2144 Evl 160667_at U72519 Ena-vasodilator stimulated phosphoprotein3859 0.17646 2.47 up Mm.10658 Gsta1 160063_i_at M19256 glutathione S-transferase, alpha 1 (Ya)3860 0.17655 2.02 up 101731_at M123743861 0.17660 1.27 down Mm.26940 Cbr1 96110_at U31966 carbonyl reductase 13862 0.17663 1.28 up Mm.10125 Cdv1 102215_at Y10495 carnitine deficiency-associated gene expressed in ventricle 13863 0.17666 1.34 down Mm.6407 D9Ertd280e 161075_at AI226337 DNA segment, Chr 9, ERATO Doi 280, expressed3864 0.17669 2.26 up Mm.46207 Mm.46207 161843_at AV003017 ESTs3865 0.17671 1.76 up Mm.25012 C79130 95880_s_at C79086 expressed sequence C791303866 0.17680 1.29 down Mm.2204 Mm.2204 160679_at AW121381 Mus musculus, clone MGC:28766 IMAGE:4485843, mRNA, complete cds3867 0.17688 2.80 up Mm.197552 Tgfbr1 92427_at D25540 transforming growth factor, beta receptor I3868 0.17691 1.72 up Mm.12440 Rnasep2-pending 160071_at U95123 ribonuclease P23869 0.17696 1.66 up Mm.2923 Il2rg 96807_at X75337 interleukin 2 receptor, gamma chain3870 0.17719 1.54 up Mm.7984 Zan 99888_at U83190 zonadhesinPage 43 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description3871 0.17736 2.16 down Mm.5277 R74640 93159_at AW122995 expressed sequence R746403872 0.17737 2.11 up Mm.20304 Bat2 95311_at AF073932 HLA-B associated transcript 23873 0.17740 2.68 up Mm.4486 Klk6 100060_i_at M13500 kallikrein 63874 0.17742 1.51 up Mm.21075 Calm4 93744_at AI119347 calmodulin 43875 0.17742 1.75 up Mm.29811 1190002H23Rik 160359_at AI854358 RIKEN cDNA 1190002H23 gene3876 0.17743 4.02 up Mm.2639 Ly86 94425_at AB007599 lymphocyte antigen 863877 0.17743 1.71 up Mm.21129 2210409E12Rik 103867_at AA822813 RIKEN cDNA 2210409E12 gene3878 0.17748 3.31 up Mm.2254 Emr1 161377_at AV244683 EGF-like module containing, mucin-like, hormone receptor-like sequence 13879 0.17754 2.79 up Mm.4073 Acrbp 99456_at D17573 proacrosin binding protein3880 0.17763 1.28 down Mm.196365 4833416I09Rik 98908_at AW125510 RIKEN cDNA 4833416I09 gene3881 0.17765 1.86 up Mm.20455 G2a-pending 94566_at AF083442 G protein-coupled receptor G2A3882 0.17773 1.62 up Mm.6332 Alox15b 99848_at Y14696 arachidonate 15-lipoxygenase, second type3883 0.17780 2.34 up Mm.2209 Cd4 99238_at AC002397 CD4 antigen3884 0.17786 1.22 up Mm.38173 6030457N17Rik 160448_at AI646750 RIKEN cDNA 6030457N17 gene3885 0.17790 1.33 down Mm.28984 D10Jhu81e 96757_at AI852165 DNA segment, Chr 10, Johns Hopkins University 81 expressed3886 0.17792 1.58 up Mm.5056 Psg17 98846_f_at M83344 pregnancy specific glycoprotein 173887 0.17799 1.48 up Mm.5650 Mm.5650 101226_at C77776 ESTs3888 0.17803 1.90 up Mm.3944 Prss18 92353_at Y18723 protease, serine, 183889 0.17807 1.83 up Mm.21193 Cyp3a11 93770_at X60452 cytochrome P450, steroid inducible 3a113890 0.17815 1.49 down Mm.3986 Ghr 99107_at M31680 growth hormone receptor3891 0.17823 1.76 up Mm.38756 Pcaf 161116_at AA756076 p300/CBP-associated factor3892 0.17828 2.14 up Mm.10298 Nmt2 102229_at AF043327 N-myristoyltransferase 23893 0.17841 1.34 down Mm.205569 Mm.205569 93826_at AI956230 Mus musculus, clone MGC:38798 IMAGE:5359803, mRNA, complete cds3894 0.17852 2.44 up Mm.4662 Irg1 98774_at L38281 immunoresponsive gene 13895 0.17854 1.62 down Mm.21966 4930421J07Rik 104117_at AI836641 RIKEN cDNA 4930421J07 gene3896 0.17869 1.53 up Mm.18910 Sdfr2 103421_at D50464 stromal cell derived factor receptor 23897 0.17882 3.44 up Mm.18509 Ptger4 103362_at D13458 prostaglandin E receptor 4 (subtype EP4)3898 0.17883 1.75 up Mm.35677 Eps15-rs 98497_at U29156 epidermal growth factor receptor pathway substrate 15, related sequence3899 0.17886 4.40 up Mm.20471 V1ra1 94571_at Y12725 vomeronasal 1 receptor, A13900 0.17891 2.11 up Mm.57242 Pax5 102578_at M97013 paired box gene 53901 0.17893 2.65 up Mm.1233 Fcer2a 94141_at X64224 Fc receptor, IgE, low affinity II, alpha polypeptide3902 0.17898 1.74 up Mm.42260 Foxa3 98324_at X74938 forkhead box A33903 0.17907 1.27 down Mm.30255 H2afy 97452_at AI853078 H2A histone family, member Y3904 0.17914 1.82 up Mm.21281 Rnf4 161809_r_at AV372357 ring finger protein 43905 0.17917 1.72 up Mm.2372 Tpbpa 100709_at X17071 trophoblast specific protein alpha3906 0.17918 2.41 up Mm.11526 Cd160 102272_at AF060982 CD160 antigen3907 0.17920 2.03 up Mm.30115 2310061P20Rik 97438_r_at AW122483 RIKEN cDNA 2310061P20 gene3908 0.17926 1.57 up Mm.180052 Ube2d2 162499_f_at AV171056 ubiquitin-conjugating enzyme E2D 23909 0.17928 1.50 up Mm.3601 Tfpi 98514_at AF004833 tissue factor pathway inhibitor3910 0.17933 1.61 up Mm.28541 1700012G19Rik 98890_at AI848173 RIKEN cDNA 1700012G19 gene3911 0.17934 1.60 up Mm.6479 Irf5 93425_at AF028725 interferon regulatory factor 53912 0.17948 2.56 up Mm.2924 Pdgfra 161202_r_at AV242260 platelet derived growth factor receptor, alpha polypeptide3913 0.17953 2.20 up Mm.30066 Rpl8 162476_r_at AV092840 ribosomal protein L83914 0.17953 1.38 down Mm.10226 Igf1r 102224_at AF056187 insulin-like growth factor I receptor3915 0.17961 2.51 up Mm.21671 D5Wsu45e 161743_i_at AV317706 DNA segment, Chr 5, Wayne State University 45, expressed3916 0.17975 1.71 down Mm.182944 3110001I17Rik 101507_at AI836274 RIKEN cDNA 3110001I17 gene3917 0.17986 1.78 up Mm.2816 Art5 104238_at U60881 ADP-ribosyltransferase 53918 0.17997 2.55 up Mm.4146 Pdgfrb 161154_at AV230288 platelet derived growth factor receptor, beta polypeptide3919 0.18001 1.31 down Mm.25539 Cryl1 103955_at AW050325 crystallin, lamda 13920 0.18010 2.33 up Mm.31255 Notch1 162204_r_at AV374287 Notch gene homolog 1, (Drosophila)3921 0.18012 1.45 down Mm.28660 2310004I03Rik 96211_at AI846896 RIKEN cDNA 2310004I03 gene3922 0.18012 2.31 up Mm.4496 Foxn1 92674_at X81593 forkhead box N13923 0.18018 1.89 up Mm.1167 Junb 102362_i_at U20735 Jun-B oncogene3924 0.18026 1.54 up Mm.25154 Wtap 94346_at AI853721 Wilms' tumour 1-associating protein3925 0.18033 2.79 up Mm.87487 Mm.87487 161084_at AI603944 Mus musculus, clone IMAGE:3586510, mRNA, partial cds3926 0.18038 1.65 up Mm.2210 Abca2 104137_at X75927 ATP-binding cassette, sub-family A (ABC1), member 23927 0.18041 1.40 up Mm.21739 Fus1-pending 160142_at AW122983 fusion 13928 0.18052 1.44 up Mm.5089 Sall3 98852_at X97581 sal-like 3 (Drosophila)3929 0.18053 2.07 up Mm.30 4930422J18Rik 161817_f_at AV376312 RIKEN cDNA 4930422J18 gene3930 0.18055 1.48 up Mm.5915 2410012M04Rik 100912_at AI182009 RIKEN cDNA 2410012M04 gene3931 0.18060 1.68 up Mm.148721 Atp5f1 96898_at U29530 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b, isoform3932 0.18065 2.26 up Mm.14302 Cmkbr5 102718_at AF022990 chemokine (C-C) receptor 53933 0.18079 1.97 up Mm.41814 Mm.41814 161096_at AA209597 ESTs, Weakly similar to Y211_HUMAN Hypothetical zinc finger protein KIAA3934 0.18084 1.28 up Mm.3199 1500001N04Rik 97517_at AW061222 RIKEN cDNA 1500001N04 gene3935 0.18084 4.99 up Mm.157783 AI893585 161486_f_at AV080003 expressed sequence AI8935853936 0.18095 1.37 down Mm.154153 1110034O07Rik 160245_at AW045564 RIKEN cDNA 1110034O07 gene3937 0.18096 1.95 up Mm.2958 AI843786 161010_r_at AI843786 expressed sequence AI8437863938 0.18096 1.72 up Mm.282 Gsto1 97819_at AI843119 glutathione S-transferase omega 13939 0.18098 1.79 up Mm.1360 Gadd45b 102779_at X54149 growth arrest and DNA-damage-inducible 45 beta3940 0.18101 1.68 down Mm.27649 4930588A18Rik 96717_at AW122643 RIKEN cDNA 4930588A18 gene3941 0.18107 2.16 up Mm.849 Ppm1b 101838_r_at AB007798 protein phosphatase 1B, magnesium dependent, beta isoform3942 0.18116 1.22 down Mm.27862 Mm.27862 95587_at AI837204 ESTs, Weakly similar to T16757 hypothetical protein R144.3 - Caenorhabditi3943 0.18118 1.20 up Mm.29822 Hp1bp3 96257_at AW124376 heterochromatin protein 2, binding protein 33944 0.18119 1.59 down Mm.22369 4930533O14Rik 104306_at AI847886 RIKEN cDNA 4930533O14 gene3945 0.18125 2.33 up Mm.1019 Il6 102218_at X54542 interleukin 63946 0.18126 5.53 up Mm.1405 Wbp2 161991_at AV325341 WW domain binding protein 23947 0.18127 1.37 down Mm.29187 Lmo4 98122_at AF074600 LIM only 43948 0.18129 1.43 down Mm.16562 Actg2 93102_f_at U20365 actin, gamma 2, smooth muscle, enteric3949 0.18133 2.36 up Mm.4679 Gdnf 161598_at AV296394 glial cell line derived neurotrophic factor3950 0.18136 1.65 up Mm.4742 Pa2g4 100125_at U43918 proliferation-associated 2G4, 38kD3951 0.18137 1.61 up 99798_at X032783952 0.18137 1.39 up Mm.151329 Mm.151329 161757_f_at AV298789 Mus musculus Ran binding protein 5 mRNA, partial cds3953 0.18141 2.76 up Mm.20880 Sh2d1a 103279_at AF097632 SH2 domain protein 1A3954 0.18151 1.39 down Mm.44202 5330422J23Rik 99675_at AI839766 RIKEN cDNA 5330422J23 gene3955 0.18159 3.02 up Mm.21123 Retnlb 93755_at AA611740 resistin like beta3956 0.18159 1.60 up Mm.20901 Pex11b 103815_at AI852311 peroxisomal biogenesis factor 11b3957 0.18161 1.87 up Mm.7634 Lbcl1 93632_g_at X95761 lymphoid blast crisis-like 13958 0.18162 1.38 down Mm.29382 1110038D17Rik 95119_at AA866888 RIKEN cDNA 1110038D17 gene3959 0.18164 1.31 up Mm.988 1500004O06Rik 102000_f_at AI842835 RIKEN cDNA 1500004O06 gene3960 0.18170 2.03 up Mm.34209 Nr0b2 97123_at L76567 nuclear receptor subfamily 0, group B, member 2Page 44 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description3961 0.18181 2.47 up Mm.4519 Ryr1 100003_at D38216 ryanodine receptor 1, skeletal muscle3962 0.18192 2.54 up Mm.5074 Lalba 92994_at M87863 lactalbumin, alpha3963 0.18194 1.79 up Mm.625 Sprr1a 161312_r_at AV085264 small proline-rich protein 1A3964 0.18211 1.32 up Mm.880 Int6 160554_at AI839363 mammary tumor integration site 63965 0.18214 2.45 up Mm.27830 Slc7a8 104214_at AW122706 solute carrier family 7 (cationic amino acid transporter, y+ system), member3966 0.18218 2.51 up Mm.28178 Krt1-3 97814_at X75650 keratin complex 1, acidic, gene 33967 0.18219 1.92 up Mm.22152 2610025P08Rik 104146_at AI853551 RIKEN cDNA 2610025P08 gene3968 0.18220 1.31 up Mm.29714 1200009C21Rik 95715_at AW125739 RIKEN cDNA 1200009C21 gene3969 0.18222 1.59 up Mm.1428 Gata4 102713_at M98339 GATA binding protein 43970 0.18233 2.44 up Mm.21545 Tdo2 99269_g_at AI194855 tryptophan 2,3-dioxygenase3971 0.18235 1.14 up Mm.1144 2410117E06Rik 102271_at AW125462 RIKEN cDNA 2410117E06 gene3972 0.18239 1.84 up Mm.153833 Cdk5r2 101335_at U90267 cyclin-dependent kinase 5, regulatory subunit 2 (p39)3973 0.18265 1.21 up Mm.148348 1500005G05Rik 103921_i_at AI839690 RIKEN cDNA 1500005G05 gene3974 0.18273 1.87 up Mm.41038 Mm.41038 93707_f_at AA646859 ESTs, Weakly similar to ZINC FINGER PROTEIN MLZ-4 [M.musculus]3975 0.18280 1.58 up Mm.76694 1110067D22Rik 160704_at AW121603 RIKEN cDNA 1110067D22 gene3976 0.18281 1.90 up Mm.5824 D3Ertd246e 101605_at C79364 DNA segment, Chr 3, ERATO Doi 246, expressed3977 0.18310 3.72 up Mm.200919 AI450287 161089_r_at AV367756 expressed sequence AI4502873978 0.18314 1.27 up Mm.4723 Sct 92756_r_at X73580 secretin3979 0.18316 1.30 down Mm.1538 Btf3 93057_at AW122989 basic transcription factor 33980 0.18317 1.61 up Mm.182962 Eif3s5 160541_at AW124660 eukaryotic translation initiation factor 3, subunit 5 (epsilon)3981 0.18322 4.48 up Mm.86813 Col8a1 100308_at X66976 procollagen, type VIII, alpha 13982 0.18325 1.29 down Mm.21963 AA409398 104115_at AA867340 expressed sequence AA4093983983 0.18342 1.58 up Mm.57155 Fshr 101810_at AF095642 follicle stimulating hormone receptor3984 0.18345 2.27 up Mm.89940 Adam19 103554_at AA726223 a disintegrin and metalloproteinase domain 19 (meltrin beta)3985 0.18346 1.49 up Mm.23793 Cncg 101706_at AJ238239 cyclic nucleotide gated channel, cGMP gated3986 0.18352 1.29 down Mm.23943 Vapa 94889_at AW121235 vesicle-associated membrane protein, associated protein A (33 kDa)3987 0.18360 1.57 up Mm.80325 AA407874 92279_at AW121320 EST AA4078743988 0.18361 1.59 up Mm.3797 Nap1l1 98586_at AW107230 nucleosome assembly protein 1-like 13989 0.18362 2.30 up Mm.2576 Brp44l 96028_at AW125628 brain protein 44-like3990 0.18370 1.68 up Mm.12255 2310042P20Rik 160595_at AI842450 RIKEN cDNA 2310042P20 gene3991 0.18377 1.27 down Mm.1989 Sca2 162399_f_at AV276058 spinocerebellar ataxia 2 homolog (human)3992 0.18377 1.91 up Mm.2811 Chrnd 96549_at L10076 cholinergic receptor, nicotinic, delta polypeptide3993 0.18379 2.96 up Mm.41988 Scya17 97783_at AJ242587 small inducible cytokine subfamily A173994 0.18379 1.48 down Mm.16528 Myog 103053_at X15784 myogenin3995 0.18383 1.32 down Mm.22668 Hmgcl 94324_f_at U49878 3-hydroxy-3-methylglutaryl-Coenzyme A lyase3996 0.18387 1.88 up Mm.41939 1110018D06Rik 99195_at AW120734 RIKEN cDNA 1110018D06 gene3997 0.18396 1.88 up Mm.9020 Mrc2 100759_at U56734 mannose receptor, C type 23998 0.18397 1.97 up Mm.153446 Pla2g5 94665_at AA408341 phospholipase A2, group V3999 0.18402 1.89 up Mm.22194 Prg 94085_at M34603 proteoglycan, secretory granule4000 0.18403 1.58 down Mm.196000 Col18a1 101882_s_at U03715 procollagen, type XVIII, alpha 14001 0.18405 2.84 up Mm.3532 Tmsb10 98129_at AI852553 thymosin, beta 104002 0.18406 1.30 down Mm.28463 Ap3d 96185_at AB004305 adaptor-related protein complex AP-3, delta subunit4003 0.18408 2.01 up Mm.231 Rad51 104527_at D13803 RAD51 homolog (S. cerevisiae)4004 0.18416 2.68 up Mm.194940 AI194696 94994_at M29007 expressed sequence AI1946964005 0.18417 2.41 up Mm.42044 Icos 98282_at AB023132 inducible T-cell co-stimulator4006 0.18423 2.25 up Mm.44184 AA408776 99966_at AA274528 expressed sequence AA4087764007 0.18442 2.78 up Mm.217538 Mm.217538 95246_at AA516958 EST, Weakly similar to TYROSINE-PROTEIN KINASE JAK3 [M.musculus]4008 0.18455 1.45 down Mm.77432 Txnip 160547_s_at AI839138 thioredoxin interacting protein4009 0.18465 1.29 up Mm.42083 Plcb1 92466_at U85714 phospholipase C, beta 14010 0.18465 1.34 up Mm.20445 Tspyl 95326_at AF042180 <strong>test</strong>is-specific protein, Y-encoded-like4011 0.18468 1.33 down Mm.179650 Prkcabp 97684_at Z46720 protein kinase C, alpha binding protein4012 0.18468 2.22 up Mm.108242 Dnahc8 95299_at AA144987 dynein, axon, heavy chain 84013 0.18475 1.60 down Mm.41979 Mcpt8 97779_at X78545 mast cell protease 84014 0.18477 2.20 up Mm.33972 D7Ertd59e 97120_at C77679 DNA segment, Chr 7, ERATO Doi 59, expressed4015 0.18480 2.15 up Mm.10656 Mm.10656 97073_at L17305 Mouse granuloma associated factor mRNA, complete cds4016 0.18484 1.23 up Mm.1616 Ctf1 103037_at U18366 cardiotrophin 14017 0.18488 1.68 down Mm.12947 Mona 102633_at AF053405 monocytic adaptor4018 0.18492 1.35 down Mm.22711 Ccni 94819_f_at AF005886 cyclin I4019 0.18496 1.30 down Mm.24116 5730589N07Rik 103713_at AW124533 RIKEN cDNA 5730589N07 gene4020 0.18498 1.84 up Mm.108678 Cyp11a 96228_at AW121619 cytochrome P450, 11a, cholesterol side chain cleavage4021 0.18499 1.52 down Mm.7013 0610038L10Rik 97104_g_at AF031380 RIKEN cDNA 0610038L10 gene4022 0.18501 1.63 down Mm.24395 Decr1 160711_at AI844846 2,4-dienoyl CoA reductase 1, mitochondrial4023 0.18513 1.49 up Mm.30927 3300001P08Rik 160791_at AW049254 RIKEN cDNA 3300001P08 gene4024 0.18520 2.00 up Mm.38347 1500005I02Rik 161082_r_at AA016517 RIKEN cDNA 1500005I02 gene4025 0.18525 3.00 up Mm.100109 Siat10 102208_at AI153959 sialyltransferase 10 (alpha-2,3-sialyltransferase VI)4026 0.18531 2.29 up Mm.2527 Gata5 96500_at U84725 GATA binding protein 54027 0.18541 1.82 up Mm.141666 Krt1-c29 93800_f_at AB013607 keratin complex-1, acidic, gene C294028 0.18579 2.01 down Mm.67919 Mafb 102204_at L36435 v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)4029 0.18598 1.43 down Mm.21173 2310015N07Rik 103873_i_at AA684456 RIKEN cDNA 2310015N07 gene4030 0.18610 2.64 up Mm.1371 Pax3 100697_at X59358 paired box gene 34031 0.18613 1.92 up Mm.181021 Col4a2 101039_at X04647 procollagen, type IV, alpha 24032 0.18614 1.52 down Mm.28207 D4Wsu132e 160773_at AI846285 DNA segment, Chr 4, Wayne State University 132, expressed4033 0.18621 1.75 up Mm.19016 Dbn1 103430_at AW124952 drebrin 14034 0.18623 1.60 up Mm.28406 Mm.28406 160781_r_at AW215456 Mus musculus, Similar to unc93 (C.elegans) homolog B, clone MGC:25627 I4035 0.18632 3.18 up Mm.6258 Eda 93394_at AF004435 ectodysplasin-A4036 0.18636 1.45 down Mm.27363 1110003O22Rik 96662_at AI847054 RIKEN cDNA 1110003O22 gene4037 0.18638 1.52 up Mm.7997 Foxd2 94621_at AF023915 forkhead box D24038 0.18639 2.31 up Mm.57128 Ifna4 101790_f_at X01973 interferon alpha family, gene 44039 0.18639 2.30 up Mm.25620 Dntt 103961_s_at X68670 deoxynucleotidyltransferase, terminal4040 0.18657 3.22 up Mm.4554 Laptm5 161819_f_at AV356071 lysosomal-associated protein transmembrane 54041 0.18668 1.20 down Mm.1147 Calm3 92631_f_at M19380 calmodulin 34042 0.18672 2.15 up Mm.25070 Mm.25070 95998_at C79930 ESTs4043 0.18690 1.37 down Mm.23044 AA409679 160963_at AI551141 expressed sequence AA4096794044 0.18699 2.98 up Mm.27880 Cugbp2 93892_at Y18298 CUG triplet repeat,RNA binding protein 24045 0.18702 2.02 up Mm.4938 Fmn 92953_at U60969 formin4046 0.18711 2.14 down Mm.14825 Idh3g 162478_r_at AV097887 isocitrate dehydrogenase 3 (NAD+), gamma4047 0.18714 1.58 up Mm.196640 2610511G02Rik 96806_at AI843802 RIKEN cDNA 2610511G02 gene4048 0.18719 1.22 up Mm.21092 AW742319 93747_at AW122599 expressed sequence AW7423194049 0.18720 1.46 up Mm.141936 Igfbp2 98627_at X81580 insulin-like growth factor binding protein 24050 0.18730 1.79 up Mm.30355 Kif5a 96583_s_at AF053473 kinesin family member 5APage 45 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description4051 0.18731 1.36 down Mm.141276 Sdbcag84 96345_at AI837012 serologically defined breast cancer antigen 844052 0.18745 1.61 up Mm.6471 Mm.6471 93423_at AI844772 Mus musculus, clone MGC:38821 IMAGE:5360322, mRNA, complete cds4053 0.18760 3.61 up Mm.4640 Lrrn1 161959_f_at AV221593 leucine rich repeat protein 1, neuronal4054 0.18769 2.48 up Mm.4237 Top2a 99578_at U01915 topoisomerase (DNA) II alpha4055 0.18770 1.45 up Mm.28018 1500006O09Rik 160260_at AI836346 RIKEN cDNA 1500006O09 gene4056 0.18774 2.10 up Mm.14487 Map2k6 102829_s_at X97052 mitogen activated protein kinase kinase 64057 0.18781 1.41 down Mm.34556 Car14 98079_at AB005450 carbonic anhydrase 144058 0.18784 1.22 down Mm.30006 1500035H01Rik 97423_at AI839819 RIKEN cDNA 1500035H01 gene4059 0.18787 2.56 up Mm.141197 Wbp11 161582_r_at AV317102 WW domain binding protein 114060 0.18788 1.94 up Mm.4722 Kcnj11 98787_at D50581 potassium inwardly rectifying channel, subfamily J, member 114061 0.18789 1.64 up Mm.56986 Has3 99394_at U86408 hyaluronan synthase 34062 0.18790 1.86 up Mm.2582 Vps45 94404_at U66865 vacuolar protein sorting 45 (yeast)4063 0.18794 1.32 down Mm.2006 Tagln 93541_at Z68618 transgelin4064 0.18808 2.25 up Mm.8217 D6H12S2489E 93678_s_at AF054819 DNA Segment, Chr 6, human D12S2489E4065 0.18814 1.87 up Mm.1287 Mapt 102743_at M18776 microtubule-associated protein tau4066 0.18825 2.09 up Mm.14526 Mylpf 92881_at U77943 myosin light chain, phosphorylatable, fast skeletal muscle4067 0.18845 2.51 up Mm.8012 Mm.8012 93657_at U87620 Mus musculus Ets transcription factor Spi-B, partial cds4068 0.18845 1.53 down Mm.3129 Stxbp1 97983_s_at D45903 syntaxin binding protein 14069 0.18847 1.62 up Mm.686 Actc1 101028_i_at M15501 actin, alpha, cardiac4070 0.18851 1.96 down Mm.29735 0610006H10Rik 95725_at AI314227 RIKEN cDNA 0610006H10 gene4071 0.18852 1.38 up Mm.28088 Mvk 95633_r_at AW122653 mevalonate kinase4072 0.18852 1.29 down Mm.181430 Dnchc1 97333_at AW121185 dynein, cytoplasmic, heavy chain 14073 0.18857 1.54 up Mm.4142 Ttgn1 99144_s_at D50031 trans-golgi network protein 14074 0.18861 2.24 up Mm.34324 5830461H18Rik 92212_at AI849862 RIKEN cDNA 5830461H18 gene4075 0.18861 3.54 up Mm.37854 Ptprm 92309_i_at X58287 protein tyrosine phosphatase, receptor-type, M4076 0.18868 1.55 up Mm.4631 2310079H06Rik 162203_r_at AV373867 RIKEN cDNA 2310079H06 gene4077 0.18875 1.83 up Mm.4983 Mc1r 101161_at X65635 melanocortin 1 receptor4078 0.18882 1.65 down Mm.4219 Man2b1 99562_at U87240 mannosidase 2, alpha B14079 0.18896 1.53 up Mm.20872 Large 103276_at AJ006278 like-glycosyltransferase4080 0.18903 1.66 up Mm.26939 Rap2b 104020_at AI837726 RAP2B, member of RAS oncogene family4081 0.18903 2.93 up Mm.42233 Aanat 92511_at AF004108 arylalkylamine N-acetyltransferase4082 0.18925 2.32 up Mm.3970 Elavl4 92361_at D31953 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)4083 0.18927 1.88 up Mm.1370 Pde6a 100696_at X60664 phosphodiesterase 6A, cGMP-specific, rod, alpha4084 0.18936 1.67 up Mm.2509 Col6a1 162459_f_at AV010209 procollagen, type VI, alpha 14085 0.18944 1.23 up Mm.177451 5730544L10Rik 96674_at AW123553 RIKEN cDNA 5730544L10 gene4086 0.18944 2.04 up Mm.27740 AA987150 160246_at AI839109 expressed sequence AA9871504087 0.18951 1.48 up Mm.9002 Ube3a 101581_at U82122 ubiquitin protein ligase E3A4088 0.18959 2.49 up Mm.24187 AI415282 94921_i_at AA220757 expressed sequence AI4152824089 0.18961 2.65 up Mm.3765 1700094D03Rik 98578_at AA692915 RIKEN cDNA 1700094D03 gene4090 0.18970 1.25 down Mm.21743 Mor1 93991_at X07295 malate dehydrogenase, mitochondrial4091 0.18970 2.43 up Mm.3460 Cd14 98088_at X13333 CD14 antigen4092 0.18974 1.77 up Mm.218865 Tnfrsf9 97683_at U02567 tumor necrosis factor receptor superfamily, member 94093 0.18986 2.23 up Mm.46795 Ifna7 102149_f_at M13710 interferon alpha family, gene 74094 0.18993 2.27 up Mm.28805 Set 161182_r_at AV234941 SET translocation4095 0.19004 3.26 up Mm.28687 Msn 160308_at AI839417 moesin4096 0.19010 2.00 up Mm.42020 Ahrr 101709_at AB015140 aryl-hydrocarbon receptor repressor4097 0.19020 3.14 up Mm.4353 Cdx4 98347_at L08061 caudal type homeo box 44098 0.19025 2.58 up Mm.5022 Mmp13 100484_at X66473 matrix metalloproteinase 134099 0.19028 3.03 up Mm.3040 Fgl2 162289_at AV374876 fibrinogen-like protein 24100 0.19036 2.19 up Mm.381 Adfp 98589_at M93275 adipose differentiation related protein4101 0.19036 1.54 up Mm.40447 Cegf1 101732_at M12039 CUB domain and EGF-like repeat containing 14102 0.19037 2.73 up Mm.5171 Stra8 101194_at Z75287 stimulated by retinoic acid gene 84103 0.19047 1.65 up Mm.1255 Scya4 94146_at X62502 small inducible cytokine A44104 0.19047 2.38 up Mm.5348 1700010P14Rik 161213_r_at AV264887 RIKEN cDNA 1700010P14 gene4105 0.19052 1.66 up Mm.27738 1700020M16Rik 161751_f_at AV324916 RIKEN cDNA 1700020M16 gene4106 0.19058 1.70 up Mm.5353 AI845814 93173_at AI845814 expressed sequence AI8458144107 0.19061 1.64 up Mm.2817 Ppfibp2 160771_r_at U79024 protein tyrosine phosphatase, receptor-type, F interacting protein, binding pro4108 0.19061 2.06 down Mm.203556 BC003494 161677_r_at AV171666 hypothetical protein, MGC:69434109 0.19072 1.35 down Mm.1056 Slc1a7 92582_at L42115 solute carrier family 1, member 74110 0.19098 1.42 down Mm.25125 5730409F23Rik 95496_at AI848866 RIKEN cDNA 5730409F23 gene4111 0.19111 1.55 up Mm.2573 Ahcy 96025_g_at L32836 S-adenosylhomocysteine hydrolase4112 0.19134 1.22 down Mm.38994 2600001N01Rik 99087_at AW060179 RIKEN cDNA 2600001N01 gene4113 0.19148 1.44 down Mm.29571 1200017E04Rik 95665_at AI852087 RIKEN cDNA 1200017E04 gene4114 0.19149 1.83 up Mm.19353 LOC56304 100722_r_at U10410 recombinant antineuraminidase single chain Ig VH and VL domains4115 0.19153 2.51 up Mm.8073 Bche 94644_at M99492 butyrylcholinesterase4116 0.19160 1.33 down Mm.3131 Dld 97502_at U73445 dihydrolipoamide dehydrogenase4117 0.19164 1.99 up Mm.57212 Adra2a 102556_at M99377 adrenergic receptor, alpha 2a4118 0.19169 1.92 up Mm.192181 Abcd4 93867_at AJ001166 ATP-binding cassette, sub-family D (ALD), member 44119 0.19173 12.32 up Mm.42029 Scya8 92459_at AB023418 small inducible cytokine A84120 0.19173 1.92 up Mm.3819 Col12a1 92313_at AI844066 procollagen, type XII, alpha 14121 0.19174 2.05 up Mm.135092 Mm.135092 162040_r_at AV374320 ESTs, Weakly similar to T14031 sodium bicarbonate cotransporter, pancreat4122 0.19178 1.33 down Mm.28596 C85108 104274_at AW124843 expressed sequence C851084123 0.19178 1.78 up Mm.14860 Anxa1 161703_f_at AV003419 annexin A14124 0.19179 2.55 up Mm.10116 Scyb13 102025_at AF030636 small inducible cytokine subfamily B (Cys-X-Cys), member 134125 0.19182 3.56 up Mm.3266 Evi2 98025_at M34896 ecotropic viral integration site 24126 0.19186 1.48 up Mm.2424 Rpl10a 100711_at U12403 ribosomal protein L10A4127 0.19189 1.61 down Mm.20947 Rad17 103840_at AJ011923 RAD17 homolog (S. pombe)4128 0.19193 1.85 up Mm.37832 2310022L06Rik 97694_at AU040601 RIKEN cDNA 2310022L06 gene4129 0.19193 4.52 up Mm.4389 Man1b 92650_at U03458 mannosidase 1, beta4130 0.19194 1.48 up Mm.6765 Siah1a 100985_at Z19579 seven in absentia 1A4131 0.19204 1.51 up Mm.200422 AU020206 104252_at AW123823 expressed sequence AU0202064132 0.19206 2.06 up Mm.5507 C76554 99355_r_at C76554 expressed sequence C765544133 0.19232 1.85 up Mm.34447 V2r15 97127_f_at AF011425 vomeronasal 2, receptor, 154134 0.19234 1.73 up Mm.134988 AI605202 102211_r_at U66835 expressed sequence AI6052024135 0.19237 1.45 up Mm.1703 Tubb5 94789_r_at X04663 tubulin, beta 54136 0.19237 1.60 down Mm.135092 Mm.135092 93471_at AI594427 ESTs, Weakly similar to T14031 sodium bicarbonate cotransporter, pancreat4137 0.19244 1.52 up Mm.28176 C81205 96550_at C81401 expressed sequence C812054138 0.19245 2.46 up Mm.30211 Scyb14 96953_at AW120786 small inducible cytokine subfamily B (Cys-X-Cys), member 144139 0.19246 1.34 up Mm.14569 AI256776 160079_i_at AI845773 expressed sequence AI2567764140 0.19246 2.84 up Mm.21974 Csk 162504_at AV160784 c-src tyrosine kinasePage 46 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description4141 0.19249 2.90 up Mm.17336 Hemt1 102948_at AJ242830 hematopoietic cell transcript 14142 0.19250 1.63 up Mm.5184 Prss7 99324_at U73378 protease, serine, 7 (enterokinase)4143 0.19263 1.58 up Mm.4595 Fbl 160503_at Z22593 fibrillarin4144 0.19265 2.13 up 160375_at AJ0064744145 0.19282 1.77 up Mm.1736 Chl1 161239_r_at AV281386 close homolog of L14146 0.19284 1.80 down Mm.4312 Slc9a1 99922_at U51112 solute carrier family 9 (sodium/hydrogen exchanger), member 14147 0.19284 1.78 up Mm.28427 Lt1 162111_r_at AV295836 lurcher transcript 14148 0.19285 3.16 up Mm.3941 Eif4e 162222_r_at AV115237 eukaryotic translation initiation factor 4E4149 0.19297 2.34 up Mm.10725 Tesp1 102244_at AB008910 <strong>test</strong>icular serine protease 14150 0.19310 1.61 down Mm.12898 Traf1 94186_at L35302 Tnf receptor-associated factor 14151 0.19315 1.34 down Mm.18485 2700059C12Rik 93312_at AW124623 RIKEN cDNA 2700059C12 gene4152 0.19318 2.17 up Mm.4054 Tbxas1 162136_r_at AV380691 thromboxane A synthase 1, platelet4153 0.19328 1.96 up Mm.27949 Posh-pending 100707_at AF030131 plenty of SH3 domains4154 0.19328 2.07 up Mm.24810 Mm.24810 95936_at AI594426 ESTs4155 0.19329 2.27 up Mm.12826 Siat8a 94164_at X84235 sialyltransferase 8 (alpha-2, 8-sialytransferase) A4156 0.19334 1.83 up Mm.24801 AV001382 160978_at AW261569 expressed sequence AV0013824157 0.19335 1.62 up Mm.1423 Lyst 94736_at U52461 lysosomal trafficking regulator4158 0.19344 1.46 up Mm.141054 5530600A18Rik 98464_at AW124196 RIKEN cDNA 5530600A18 gene4159 0.19361 1.38 down Mm.24984 4930560O18Rik 103916_at AI850713 RIKEN cDNA 4930560O18 gene4160 0.19365 1.64 up Mm.88843 Olfr37c 97001_r_at AJ133426 olfactory receptor 37c4161 0.19375 1.61 up Mm.5300 Tp120a-pending 99338_at AA674798 TBP-interacting protein4162 0.19375 1.65 up Mm.22378 Itgax 104308_at AI035495 integrin alpha X4163 0.19380 1.81 up Mm.21096 Eral1 103859_at AA863768 Era (G-protein)-like 1 (E. coli)4164 0.19388 1.75 up Mm.4642 Calcr 101135_at U18542 calcitonin receptor4165 0.19400 2.46 up Mm.12806 Ptafr 94157_i_at AF004858 platelet-activating factor receptor4166 0.19402 1.57 up Mm.19961 Mm.19961 103593_at K02781 ESTs, Highly similar to ANF MOUSE ATRIAL NATRIURETIC FACTOR PRE4167 0.19416 2.24 up Mm.4664 Tnfsf8 101136_at L09754 tumor necrosis factor (ligand) superfamily, member 84168 0.19439 2.26 up Mm.42224 F12 92509_at X99571 coagulation factor XII (Hageman factor)4169 0.19442 1.92 up Mm.4539 Psp 100080_at X01697 parotid secretory protein4170 0.19443 1.43 up Mm.30249 Galnt1 97934_at U73820 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltra4171 0.19456 1.58 up Mm.326 1110038L14Rik 97527_at AA681998 RIKEN cDNA 1110038L14 gene4172 0.19465 1.40 down Mm.29985 2310010I22Rik 97419_at AW060956 RIKEN cDNA 2310010I22 gene4173 0.19473 1.88 up Mm.3322 H2-DMb1 98035_g_at U35330 histocompatibility 2, class II, locus Mb14174 0.19474 1.42 down Mm.202841 AL024279 95128_at AI849611 expressed sequence AL0242794175 0.19476 1.61 up Mm.21551 9130009C22Rik 103446_at AA959954 RIKEN cDNA 9130009C22 gene4176 0.19485 2.01 down Mm.38211 Mm.38211 98594_at AW125453 ESTs4177 0.19489 3.07 up Mm.29010 Mbc2 162079_at AV331295 membrane bound C2 domain containing protein4178 0.19494 1.50 down Mm.9440 Ptdss1 101931_at AF042731 phosphatidylserine synthase 14179 0.19494 1.49 up Mm.56995 Agrp 99399_at U89486 agouti related protein4180 0.19498 2.94 up Mm.42208 Hoxa3 102087_at Y11717 homeo box A34181 0.19514 2.11 up Mm.27777 1700013H19Rik 95561_at AW120867 RIKEN cDNA 1700013H19 gene4182 0.19526 1.68 down Mm.19821 Mm.19821 160644_at AI314106 ESTs, Weakly similar to UBP4 MOUSE UBIQUITIN CARBOXYL-TERMINAL4183 0.19531 1.78 up Mm.57043 Nfkbie 101727_at AF030896 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, e4184 0.19539 1.90 up Mm.22815 Sgcd 103522_at AB024923 sarcoglycan, delta (35kD dystrophin-associated glycoprotein)4185 0.19543 1.63 up Mm.5796 C79709 99819_at C79709 expressed sequence C797094186 0.19546 1.76 up Mm.7548 AA408554 99874_at AA959291 expressed sequence AA4085544187 0.19550 3.55 up Mm.30144 Ctla2a 96912_s_at X15591 cytotoxic T lymphocyte-associated protein 2 alpha4188 0.19550 1.50 down Mm.31051 2610003J05Rik 97491_at AW123032 RIKEN cDNA 2610003J05 gene4189 0.19552 1.80 up Mm.21961 Atp6s1 103700_r_at AI646638 ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 14190 0.19557 1.28 up Mm.139675 Tssc4 160557_at AI848914 tumor-suppressing subchromosomal transferable fragment 44191 0.19564 1.99 up Mm.1259 Ngfb 102298_at M17298 nerve growth factor, beta4192 0.19574 2.26 up Mm.30322 V2r11 101645_f_at AF011421 vomeronasal 2, receptor, 114193 0.19578 1.63 up Mm.1845 Pcx 93308_s_at M97957 pyruvate decarboxylase4194 0.19581 1.34 down Mm.27493 C78303 104193_at AW047583 expressed sequence C783034195 0.19581 1.70 up Mm.56895 D17H6S56E-3 101083_s_at AF109905 DNA segment, Chr 17, human D6S56E 34196 0.19592 1.35 down Mm.200461 2010012F07Rik 97429_at AW048113 RIKEN cDNA 2010012F07 gene4197 0.19597 1.26 up Mm.86933 2900008M13Rik 102099_f_at AI843637 RIKEN cDNA 2900008M13 gene4198 0.19597 2.46 up Mm.29189 Ak1 96801_at AJ010108 adenylate kinase 14199 0.19605 1.21 down Mm.42805 AI256693 99593_at AI852355 expressed sequence AI2566934200 0.19608 1.28 up Mm.24148 AI465155 104609_at AA644817 expressed sequence AI4651554201 0.19610 2.00 up Mm.15406 Skir 94752_s_at U10531 ski/sno related4202 0.19615 1.34 down Mm.9860 4833420G17Rik 101998_at AW125086 RIKEN cDNA 4833420G17 gene4203 0.19622 2.19 up Mm.1411 Lig3 162060_r_at AV273892 ligase III, DNA, ATP-dependent4204 0.19624 1.53 down Mm.5185 Mm.5185 93143_at AI844196 ESTs4205 0.19630 1.87 up Mm.219663 Fbln1 161628_r_at AV035226 fibulin 14206 0.19635 1.66 down Mm.21868 Araf 102286_at M13071 raf-related oncogene4207 0.19637 1.75 down Mm.4103 Myom1 92407_at AJ012072 myomesin 14208 0.19640 2.01 up Mm.8367 Mbl1 101474_at U09010 mannose binding lectin, liver (A)4209 0.19650 1.71 up Mm.29390 2400007P05Rik 95122_g_at AW060791 RIKEN cDNA 2400007P05 gene4210 0.19656 2.86 up Mm.57116 Drd3 101779_at X67274 dopamine receptor 34211 0.19658 2.02 up Mm.29581 Hey1 95671_at AJ243895 hairy/enhancer-of-split related with YRPW motif 14212 0.19660 5.10 up Mm.3619 Ctss 98543_at AJ223208 cathepsin S4213 0.19663 1.53 up Mm.3908 Cbx2 97723_at X62537 chromobox homolog 2 (Drosophila Pc class)4214 0.19672 2.12 up Mm.354 Calb1 98133_at D26352 calbindin-28K4215 0.19691 2.13 up Mm.14438 AU044919 100583_at J00475 expressed sequence AU0449194216 0.19707 2.35 down Mm.57219 Npr3 99806_at D78175 natriuretic peptide receptor 34217 0.19712 1.78 up Mm.21884 Mm.21884 160961_at AI853347 ESTs, Weakly similar to T14106 probable GTPase-activating protein SPA-14218 0.19712 1.61 up Mm.154651 Purb 101395_at AW120626 purine rich element binding protein B4219 0.19718 3.66 up Mm.231 Rad51 162232_r_at AV311591 RAD51 homolog (S. cerevisiae)4220 0.19738 1.58 up Mm.22318 AU022703 103497_at AA592351 expressed sequence AU0227034221 0.19740 2.77 up Mm.9114 Crym 160937_at AF039391 crystallin, mu4222 0.19745 3.76 up Mm.42948 Prdx2 100330_at AF032714 peroxiredoxin 24223 0.19752 1.34 up Mm.1384 Trim21 92942_at AA138192 tripartite motif protein 214224 0.19758 1.43 down Mm.28637 4930569O04Rik 98924_at Y08027 RIKEN cDNA 4930569O04 gene4225 0.19770 1.31 down Mm.7198 Mkrn1 101069_g_at AA656621 makorin, ring finger protein, 14226 0.19774 1.19 down Mm.28144 0610007C21Rik 160271_at AW121255 RIKEN cDNA 0610007C21 gene4227 0.19782 1.50 down Mm.28063 AA409091 97308_at AI835409 expressed sequence AA4090914228 0.19782 1.73 up Mm.1644 Lhcgr 100705_at M81310 luteinizing hormone/choriogonadotropin receptor4229 0.19798 2.58 up Mm.4946 Ins2 161849_r_at AV051765 insulin II4230 0.19817 1.82 down Mm.27790 2610510E10Rik 95567_at AW123947 RIKEN cDNA 2610510E10 genePage 47 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description4231 0.19826 1.78 up Mm.1397 Smr2 102685_at U82380 submaxillary gland androgen regulated protein 24232 0.19831 1.20 up Mm.100113 Rpl10 161657_f_at AV105022 ribosomal protein 104233 0.19839 2.16 up Mm.39200 Pde6g 97732_at Y00746 phosphodiesterase 6G, cGMP-specific, rod, gamma4234 0.19842 1.92 down Mm.23697 Tssc3 104548_at Y15443 tumor-suppressing subchromosomal transferable fragment 34235 0.19849 1.52 up Mm.28252 1110018O12Rik 96151_at AA839813 RIKEN cDNA 1110018O12 gene4236 0.19852 1.17 down Mm.28202 D16Ertd269e 97821_at AI646056 DNA segment, Chr 16, ERATO Doi 269, expressed4237 0.19858 1.33 up Mm.4024 Cfl1 99119_at D00472 cofilin 1, non-muscle4238 0.19859 1.37 down Mm.7401 Hax1-pending 101096_s_at AF023482 HS1 binding protein4239 0.19861 2.23 up Mm.3509 Tnfip6 98474_r_at U83903 tumor necrosis factor induced protein 64240 0.19875 3.35 up Mm.5026 Phxr3 101167_at X12807 per-hexamer repeat gene 34241 0.19893 1.25 down Mm.2472 Cops5 95460_at U70736 COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thal4242 0.19901 3.91 up Mm.29800 Cdc25a 161412_r_at AV315419 cell division cycle 25 homolog A (S. cerevisiae)4243 0.19904 1.99 up Mm.14046 Krt1-17 92861_i_at M13805 keratin complex 1, acidic, gene 174244 0.19921 2.50 up Mm.6215 Fosl1 99835_at AF017128 fos-like antigen 14245 0.19924 1.31 up Mm.20805 2410141M05Rik 103672_at AW122572 RIKEN cDNA 2410141M05 gene4246 0.19952 2.63 up Mm.40678 Pde1a 99453_at U56649 phosphodiesterase 1A, calmodulin-dependent4247 0.19953 1.42 down Mm.28892 AA959742 94486_at AW125178 expressed sequence AA9597424248 0.19960 2.26 down Mm.203911 AA407887 161892_r_at AV372708 expressed sequence AA4078874249 0.19974 2.22 up Mm.28721 Brd3 98947_at AW121208 bromodomain-containing 34250 0.19977 1.54 up Mm.195525 D2Bwg0891e 99641_at AW121364 DNA segment, Chr 2, Brigham & Women's Genetics 0891 expressed4251 0.19980 2.10 up Mm.5366 Mm.5366 99348_r_at AA116459 EST4252 0.19981 3.28 up Mm.1155 Tuba4 161592_at AV291613 tubulin alpha 44253 0.19989 8.36 up Mm.147387 Col3a1 98331_at X52046 procollagen, type III, alpha 14254 0.19991 1.98 up Mm.196085 Igh-4 99850_at X01857 immunoglobulin heavy chain 4 (serum IgG1)4255 0.19994 3.03 up Mm.140768 G6pc-rs 95330_at Z47787 glucose-6-phosphatase, catalytic, related sequence4256 0.19996 1.75 down Mm.22453 1190002A23Rik 104324_at AA940036 RIKEN cDNA 1190002A23 gene4257 0.19998 1.73 up Mm.30670 Spnr 103329_at X84692 spermatid perinuclear RNA binding protein4258 0.20006 1.63 up Mm.20889 Cyp8b1 103284_at AF090317 cytochrome P450, 8b1, sterol 12 alpha-hydrolase4259 0.20011 1.30 down Mm.4005 Efnb2 160857_at U30244 ephrin B24260 0.20015 1.66 up Mm.46801 Mm.46801 96972_f_at X00651 M.musculus mRNA (2F7) for IgA V-D-J-heavy chain4261 0.20023 2.33 up Mm.882 Il1rn 93871_at L32838 interleukin 1 receptor antagonist4262 0.20024 1.72 up Mm.87787 Lta 100327_at M17015 lymphotoxin A4263 0.20033 4.56 up Mm.1639 Mcl1 162025_r_at AV257057 myeloid cell leukemia sequence 14264 0.20035 2.16 up Mm.646 Tpm2 161320_r_at AV092243 tropomyosin 2, beta4265 0.20044 1.39 down Mm.460 Supt5h 100094_at U88539 suppressor of Ty 5 homolog (S. cerevisiae)4266 0.20050 1.72 up Mm.37204 Socs5 92287_at AF033187 Socs-54267 0.20051 1.33 up Mm.27972 Nsap1-pending 94985_at AI846392 NS1-associated protein 14268 0.20066 1.64 down Mm.205266 D9Ertd25e 99571_at AW012588 DNA segment, Chr 9, ERATO Doi 25, expressed4269 0.20075 1.46 up Mm.12892 Ube1c 92818_at AF077330 ubiquitin-activating enzyme E1C4270 0.20078 1.19 up Mm.4383 Bin1 99668_at U86405 myc box dependent interacting protein 14271 0.20080 1.58 down Mm.29484 Mrps18b 95159_at AI846849 Mrps18b4272 0.20080 2.53 up Mm.143846 Ptprc 101048_at M14343 protein tyrosine phosphatase, receptor type, C4273 0.20087 1.36 down Mm.156771 3732413I11Rik 96104_at AI047107 RIKEN cDNA 3732413I11 gene4274 0.20089 1.74 down Mm.15351 1110054N06Rik 93055_at AW049376 RIKEN cDNA 1110054N06 gene4275 0.20093 1.57 up Mm.2209 Cd4 92263_at AC002397 CD4 antigen4276 0.20099 2.04 up Mm.100641 Mitf 101159_at Z23066 microphthalmia-associated transcription factor4277 0.20116 2.68 up Mm.10141 Xnp 102030_at AF026032 X-linked nuclear protein4278 0.20123 1.56 up Mm.7221 Lrp1 162002_r_at AV242154 low density lipoprotein receptor-related protein 14279 0.20127 1.72 up Mm.53259 AI256456 162467_r_at AV063606 expressed sequence AI2564564280 0.20130 1.34 up Mm.19830 Adam15 103588_at AF006196 a disintegrin and metalloproteinase domain 15 (metargidin)4281 0.20131 1.74 up Mm.206534 Mm.206534 97097_at AW125669 ESTs, Highly similar to T31099 myosin-RhoGAP protein, Myr 7 - rat [R.norve4282 0.20131 1.51 down Mm.25345 2310003C10Rik 160821_r_at AW124336 RIKEN cDNA 2310003C10 gene4283 0.20132 1.29 up Mm.29454 Npc2 160344_at AB021289 Niemann Pick type C24284 0.20140 1.95 up Mm.46801 Mm.46801 101751_f_at L43568 M.musculus mRNA (2F7) for IgA V-D-J-heavy chain4285 0.20174 1.93 up Mm.8551 Sp100 101847_at AF040242 nuclear antigen Sp1004286 0.20181 2.30 up Mm.1366 Edn2 100695_at X59556 endothelin 24287 0.20182 1.86 up Mm.153159 Cct6a 160459_r_at Z31557 chaperonin subunit 6a (zeta)4288 0.20183 1.22 down Mm.29945 Edf1 96322_at AI836001 endothelial differentiation-related factor 14289 0.20196 2.90 up Mm.6671 1110027O12Rik 93443_at AW212271 RIKEN cDNA 1110027O12 gene4290 0.20216 1.30 up Mm.21419 Taf10 103910_at AJ249987 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated facto4291 0.20219 1.35 down Mm.25306 Rab9 95516_at AB027290 RAB9, member RAS oncogene family4292 0.20219 1.63 up Mm.465 Sdf1 160511_at L12029 stromal cell derived factor 14293 0.20232 1.85 up Mm.22727 D17Wsu51e 162207_f_at AV376940 DNA segment, Chr 17, Wayne State University 51, expressed4294 0.20236 1.50 up Mm.5079 Mm.5079 100493_at X90647 Mus musculus, Similar to hydroxysteroid 11-beta dehydrogenase 2, clone MG4295 0.20236 1.26 up Mm.20047 Adprh 93540_at L13290 ADP-ribosylarginine hydrolase4296 0.20238 1.24 down Mm.3940 Llglh 99054_at D16141 lethal giant larvae homolog4297 0.20245 2.02 down Mm.182043 Itih2 104519_at X70392 inter-alpha trypsin inhibitor, heavy chain 24298 0.20252 1.29 down Mm.4537 Ndufb9 100079_at AI845556 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 94299 0.20283 1.43 down Mm.196624 Cdkap1 98532_at AF011644 CDK2 (cyclin-dependent kinase 2)-asscoaited protein 14300 0.20284 1.92 up Mm.4985 Foxj1 98831_at L13204 forkhead box J14301 0.20286 1.98 up Mm.971 Plg 101985_at J04766 plasminogen4302 0.20293 1.59 down Mm.21754 Mm.21754 93994_at AW212131 Mus musculus 10 day old male pancreas cDNA, RIKEN full-length enriched4303 0.20295 1.81 up 104191_at AI3229724304 0.20306 1.30 down Mm.21841 Sfrs2 94017_s_at X98511 splicing factor, arginine/serine-rich 2 (SC-35)4305 0.20321 1.29 down Mm.200885 AW742570 103404_at AW122831 expressed sequence AW7425704306 0.20331 1.52 up Mm.388 Ada 93205_at M14167 adenosine deaminase4307 0.20334 1.52 up Mm.35829 edr 98526_r_at AI854606 erythroid differentiation regulator4308 0.20335 1.35 up Mm.3856 Tmk 98618_at AA624336 thymidylate kinase4309 0.20338 2.05 up Mm.36302 Mm.36302 97186_s_at AA516600 ESTs4310 0.20339 1.44 down Mm.4479 Reps1 160888_at AF031939 RalBP1 associated Eps domain containing protein4311 0.20340 1.36 up Mm.3865 Seb4l 98624_at X75316 seb4-like (Xenopus laevis)4312 0.20361 1.27 down Mm.41683 0610012G03Rik 99166_at AI845963 RIKEN cDNA 0610012G03 gene4313 0.20368 1.32 down Mm.683 Oaz1 101013_at U52823 ornithine decarboxylase antizyme4314 0.20369 1.67 up Mm.1364 Npn3 102780_at Z31362 neoplastic progression 34315 0.20378 1.67 up Mm.4910 Evx1 98815_at X54239 even skipped homeotic gene 1 homolog4316 0.20383 2.68 up Mm.206770 Cnot7 160401_r_at AI931748 CCR4-NOT transcription complex, subunit 74317 0.20389 1.90 up Mm.1293 Tnf 102629_at D84196 tumor necrosis factor4318 0.20394 2.36 up Mm.24250 S17-pending 92412_s_at X81633 s17 protein4319 0.20399 1.35 down Mm.143877 5530600P05Rik 92350_at AA165759 RIKEN cDNA 5530600P05 gene4320 0.20406 1.30 down Mm.196442 Supt4h2 95795_at U96810 suppressor of Ty 4 homolog 2 (S. cerevisiae)Page 48 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description4321 0.20412 1.41 down Mm.4266 Itm2b 94535_at AW121844 integral membrane protein 2B4322 0.20417 2.00 up Mm.18929 Mm.18929 102979_at AI835278 ESTs, Weakly similar to SH2/SH3 adaptor protein [M.musculus]4323 0.20422 1.56 up Mm.196407 Igk-V21 102585_f_at AB017349 immunoglobulin kappa chain variable 21 (V21)4324 0.20423 1.36 up Mm.993 Ddx15 160572_at AF017153 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 15 (RNA helicase A)4325 0.20427 1.38 up Mm.24228 Mm.24228 95409_at AW047671 ESTs4326 0.20449 2.22 up Mm.20333 Hipk3 103233_at AF077660 homeodomain interacting protein kinase 34327 0.20454 1.44 down Mm.30250 D18Wsu181e 97449_at AI835461 DNA segment, Chr 18, Wayne State University 181, expressed4328 0.20454 1.20 down Mm.4451 Hes1 160887_at D16464 hairy and enhancer of split 1, (Drosophila)4329 0.20454 1.80 up Mm.2209 Cd4 94217_f_at AC002397 CD4 antigen4330 0.20456 1.75 down Mm.4734 Meis1 98790_s_at U33629 myeloid ecotropic viral integration site 14331 0.20459 1.24 down Mm.153865 Inppl1 102988_at U92477 inositol polyphosphate phosphatase-like 14332 0.20468 2.09 up Mm.23692 Csnk2a1-rs4 104545_at U51866 casein kinase II, alpha 1 related sequence 44333 0.20472 2.30 up Mm.27207 4932432N11Rik 160736_at AA690230 RIKEN cDNA 4932432N11 gene4334 0.20474 2.25 up Mm.10762 Tcap 92602_at AJ223855 titin-cap4335 0.20492 2.80 up Mm.27768 6330403K07Rik 161993_r_at AV327149 RIKEN cDNA 6330403K07 gene4336 0.20496 1.61 up Mm.152812 Tep1 93367_at U86137 telomerase associated protein 14337 0.20499 1.53 down Mm.3994 3830417M17Rik 97740_at AI642662 RIKEN cDNA 3830417M17 gene4338 0.20499 1.66 up Mm.3040 Fgl2 97949_at M16238 fibrinogen-like protein 24339 0.20501 2.10 up Mm.86541 Ccr4 162384_f_at AV252118 carbon catabolite repression 4 homolog (S. cerevisiae)4340 0.20505 1.88 up Mm.151790 Keap1 93601_at AB020063 kelch-like ECH-associated protein 14341 0.20506 2.61 up Mm.43751 Krtdap 99654_s_at AA726579 keratinocyte differentiation associated protein4342 0.20511 1.51 up Mm.21688 AI853222 103459_at AW124544 expressed sequence AI8532224343 0.20515 1.87 up Mm.34408 Gp49b 92217_s_at U05265 glycoprotein 49 B4344 0.20518 2.04 up Mm.157929 Mm.157929 101296_at Y10972 ESTs, Weakly similar to PBAS MOUSE PROBASIN PRECURSOR [M.muscu4345 0.20530 1.47 up Mm.2265 Snrp1c 94313_at X96767 U1 small nuclear ribonucleoprotein 1C4346 0.20533 1.43 up Mm.16122 Abcb2 103035_at U60020 ATP-binding cassette, sub-family B (MDR/TAP), member 24347 0.20539 4.63 up Mm.142140 Nfm 92346_at X05640 neurofilament, medium polypeptide4348 0.20541 1.42 down Mm.27557 Cdk9 95037_at AW046639 cyclin-dependent kinase 9 (CDC2-related kinase)4349 0.20546 1.31 down Mm.2313 Caml 104529_at U21960 calcium modulating ligand4350 0.20554 1.17 up Mm.29623 Ddb1 95682_at AB026432 damage specific DNA binding protein 1 (127 kDa)4351 0.20557 1.35 up Mm.22876 AI035728 94842_at AI853630 expressed sequence AI0357284352 0.20569 2.68 up Mm.27170 2610030J16Rik 160224_at AW047009 RIKEN cDNA 2610030J16 gene4353 0.20585 2.19 down Mm.57127 Ifna1 102150_f_at M28587 interferon alpha family, gene 14354 0.20616 1.57 down Mm.25298 Statip1 95513_at AW124310 signal transducer and activator of transcription interacting protein 14355 0.20617 1.53 up Mm.196214 H2-L 93714_f_at AI117211 histocompatibility 2, L region4356 0.20620 2.15 up Mm.157454 D8Ertd531e 93196_at C77771 DNA segment, Chr 8, ERATO Doi 531, expressed4357 0.20626 2.42 up Mm.9757 Pde8a 160941_at AF067806 phosphodiesterase 8A4358 0.20637 2.33 up Mm.212716 Mm.212716 97575_f_at AF036737 Mus musculus mRNA for immunoglobulin heavy chain, mAb 6674359 0.20645 1.33 up Mm.28550 2610016F04Rik 98894_at AA867655 RIKEN cDNA 2610016F04 gene4360 0.20654 1.35 up Mm.24997 Ptdsr 95486_at AA794134 phosphatidylserine receptor4361 0.20660 2.03 up Mm.89477 Crygf 162018_r_at AV360565 crystallin, gamma F4362 0.20663 1.91 up Mm.4418 Cacna1s 101128_at L06234 calcium channel, voltage-dependent, L type, alpha 1S subunit4363 0.20663 1.49 up Mm.30806 Rpl19 97483_at M62952 ribosomal protein L194364 0.20664 1.61 down Mm.19258 2310028D20Rik 160117_at AI850638 RIKEN cDNA 2310028D20 gene4365 0.20667 1.46 down Mm.90520 Txnrd2 160437_at AB027566 thioredoxin reductase 24366 0.20668 1.81 up Mm.4278 Kcnj9 161799_r_at AV350205 potassium inwardly-rectifying channel, subfamily J, member 94367 0.20672 1.72 up Mm.87032 Mm.87032 93847_at AW120669 ESTs, Highly similar to C54689 protein-tyrosine-phosphatase [M.musculus]4368 0.20678 1.88 up Mm.89769 Krt2-6g 161282_r_at AV294234 keratin complex 2, basic, gene 6g4369 0.20681 2.15 up Mm.21492 Mm.21492 103444_at AI272489 Mus musculus, clone IMAGE:5035239, mRNA, partial cds4370 0.20683 1.33 down Mm.21114 Mm.21114 93751_at AW048157 Mus musculus, clone MGC:11980 IMAGE:3601364, mRNA, complete cds4371 0.20697 1.61 up Mm.181422 1190005P17Rik 98089_at AI840541 RIKEN cDNA 1190005P17 gene4372 0.20697 1.39 up Mm.21834 Orc4 104096_at Y16386 origin recognition complex, subunit 44373 0.20709 1.82 up Mm.5323 AW491445 161640_at AV062432 expressed sequence AW4914454374 0.20715 3.91 up Mm.3680 D14Wsu146e 162444_r_at AV351539 DNA segment, Chr 14, Wayne State University 146, expressed4375 0.20717 1.57 up Mm.27168 Mm.27168 94958_at AI850923 ESTs, Moderately similar to COTE_HUMAN COTE1 PROTEI [H.sapiens]4376 0.20720 1.53 down Mm.29780 AU018540 95750_at AI848853 expressed sequence AU0185404377 0.20727 1.87 up Mm.5193 Klk8 104496_i_at X03994 kallikrein 84378 0.20743 1.95 up Mm.28424 Mm.28424 104261_at AA624493 ESTs, Moderately similar to T17285 hypothetical protein DKFZp434N0535.14379 0.20743 1.26 up Mm.808 Magoh 160550_i_at AF035939 mago-nashi homolog, proliferation-associated (Drosophila)4380 0.20750 1.88 down Mm.877 Scyb10 93858_at M33266 small inducible cytokine B subfamily (Cys-X-Cys), member 104381 0.20755 2.14 up Mm.21687 0610025L06Rik 95739_at AA914917 RIKEN cDNA 0610025L06 gene4382 0.20760 1.28 up Mm.157103 AI195443 160104_at AA824102 expressed sequence AI1954434383 0.20763 1.64 up Mm.859 Polg2 93699_at AF006072 polymerase, gamma 24384 0.20764 1.84 up Mm.42096 Gsbs-pending 98292_at AF071562 G substrate4385 0.20774 1.40 up Mm.20829 Emp3 93594_r_at U87948 epithelial membrane protein 34386 0.20784 1.56 up Mm.29140 1110035L05Rik 95052_at AI839150 RIKEN cDNA 1110035L05 gene4387 0.20785 2.13 up Mm.21414 Ccsd 162052_i_at AV267263 copper chaperone for superoxide dismutase4388 0.20795 1.29 down Mm.29452 2310020D23Rik 160343_at AI848458 RIKEN cDNA 2310020D23 gene4389 0.20797 1.57 up Mm.99 Rrm2 102001_at M14223 ribonucleotide reductase M24390 0.20800 1.65 down Mm.2901 Tyro3 96766_s_at AB000828 TYRO3 protein tyrosine kinase 34391 0.20807 1.66 up Mm.3894 Fkbp10 99082_at L07063 FK506 binding protein 10 (65 kDa)4392 0.20818 2.70 up Mm.371 Il4 92286_g_at AA967539 interleukin 44393 0.20820 1.70 up Mm.57234 Npy6r 99811_at U59430 neuropeptide Y receptor Y64394 0.20825 2.02 down Mm.178549 3110018A08Rik 93913_at AI043090 RIKEN cDNA 3110018A08 gene4395 0.20830 1.27 up Mm.809 Jak2 101457_at L16956 Janus kinase 24396 0.20832 1.57 up Mm.204155 AI648091 95896_at AI648091 expressed sequence AI6480914397 0.20843 2.87 up Mm.25038 Mm.25038 95985_at C79548 ESTs4398 0.20877 1.62 up Mm.18517 Rasa3 93319_at U20238 RAS p21 protein activator 34399 0.20881 1.35 down Mm.22413 1110068L01Rik 104315_at AI846773 RIKEN cDNA 1110068L01 gene4400 0.20887 1.23 down Mm.20488 1110008K06Rik 103254_at AW049897 RIKEN cDNA 1110008K06 gene4401 0.20888 1.67 up Mm.4872 Cyct 92929_at M20625 cytochrome c, <strong>test</strong>is4402 0.20892 2.93 up Mm.8011 Dmp1 99903_at AJ242625 dentin matrix protein 14403 0.20892 1.44 up Mm.2769 Mlp 97203_at X61399 MARCKS-like protein4404 0.20897 1.30 down Mm.27893 1110015E22Rik 104217_at AW045753 RIKEN cDNA 1110015E22 gene4405 0.20903 1.93 up Mm.57013 Nek4 93209_at AJ223071 NIMA (never in mitosis gene a)-related expressed kinase 44406 0.20905 2.06 down Mm.29879 5031412I06Rik 96287_at AW123785 RIKEN cDNA 5031412I06 gene4407 0.20912 1.92 up Mm.112 Tcea3 102344_s_at AI132239 transcription elongation factor A (SII), 34408 0.20913 1.32 down Mm.17166 4432409D24Rik 103079_at AA982208 RIKEN cDNA 4432409D24 gene4409 0.20921 2.07 up Mm.28643 Vamp2 98925_at U60150 vesicle-associated membrane protein 24410 0.20926 1.53 down Mm.153637 Mm.153637 99467_at AI846922 Mus musculus, Similar to RAS p21 protein activator, clone MGC:7759 IMAGPage 49 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description4411 0.20936 1.63 up Mm.4041 Dyrk1a 92383_at U58497 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a4412 0.20939 2.09 up Mm.2055 Mmp12 95338_s_at M82831 matrix metalloproteinase 124413 0.20942 1.47 up Mm.7562 Col6a3 97052_at U27810 procollagen, type VI, alpha 34414 0.20944 1.49 up Mm.2878 Sox18 161025_f_at AI836162 SRY-box containing gene 184415 0.20955 2.23 up Mm.22154 Ly6h 103487_at AI849993 lymphocyte antigen 6 complex, locus H4416 0.20963 1.30 up Mm.24477 AA959601 104714_at AW125299 expressed sequence AA9596014417 0.20968 1.63 up Mm.99113 Etl1 161920_r_at AV381829 enhancer trap locus 14418 0.20976 1.20 down Mm.183034 AA617404 94460_at AA691445 expressed sequence AA6174044419 0.20994 1.35 up Mm.4263 Cst3 161522_i_at AV218205 cystatin C4420 0.20999 1.82 up Mm.3965 Stam 161369_r_at AV239611 signal transducing adaptor molecule (SH3 domain and ITAM motif) 14421 0.21000 1.42 down Mm.154589 Mccc1 94940_at AW123316 methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)4422 0.21003 3.70 up Mm.147387 Col3a1 161984_f_at AV234303 procollagen, type III, alpha 14423 0.21005 2.34 down Mm.4450 Esp 92661_at U36488 embryonic stem cell phosphatase4424 0.21015 1.98 up Mm.42177 Rbpsuhl 92493_at Y10926 recombining binding protein suppressor of hairless-like (Drosophila)4425 0.21025 1.84 up Mm.32321 Vamp1 93653_r_at U61751 vesicle-associated membrane protein 14426 0.21033 1.32 up Mm.3399 Traf2 98416_at AF027570 Tnf receptor-associated factor 24427 0.21035 2.80 up Mm.57113 Erbb4 101777_at AF059177 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)4428 0.21064 1.50 down Mm.39088 Sox1 92342_at X94126 SRY-box containing gene 14429 0.21067 1.52 up Mm.29604 D5Wsu46e 161785_f_at AV363068 DNA segment, Chr 5, Wayne State University 46, expressed4430 0.21078 2.65 up Mm.197472 Tcp10b 103058_f_at X58171 t-complex protein 10b4431 0.21080 1.25 up Mm.24787 AA408674 103773_at AW047874 expressed sequence AA4086744432 0.21082 3.29 up Mm.57024 Ear4 101715_at AF017259 eosinophil-associated ribonuclease 44433 0.21084 1.53 up Mm.3275 Map3k8 97106_at D13759 mitogen activated protein kinase kinase kinase 84434 0.21090 2.94 up Mm.17185 Lgmn 93261_at AJ000990 legumain4435 0.21116 1.69 up Mm.1911 AA410048 103204_r_at AW259499 expressed sequence AA4100484436 0.21127 2.49 up Mm.9745 Ldh2 161945_at AV358359 lactate dehydrogenase 2, B chain4437 0.21138 3.79 up Mm.2770 Igf1 95546_g_at X04480 insulin-like growth factor 14438 0.21166 1.21 up Mm.21617 D3Ertd194e 93841_at AW060249 DNA segment, Chr 3, ERATO Doi 194, expressed4439 0.21181 1.39 down Mm.4572 Ppp1cb 100088_at M27073 protein phosphatase 1, catalytic subunit, beta isoform4440 0.21222 1.69 down Mm.27979 Mela 97282_at D10049 melanoma antigen, 80 kDa4441 0.21246 1.65 up Mm.1517 Sybl1 102885_at X96737 synaptobrevin like 14442 0.21248 1.27 up Mm.27186 C76565 160735_at AW046452 expressed sequence C765654443 0.21250 1.30 up Mm.6700 Eif4ebp1 100636_at U28656 eukaryotic translation initiation factor 4E binding protein 14444 0.21253 1.32 down Mm.2152 2600017A12Rik 160669_at AI848835 RIKEN cDNA 2600017A12 gene4445 0.21255 1.84 up Mm.2223 Tcp1 101759_at D00851 t-complex protein 14446 0.21258 1.47 up Mm.28099 Soat1 160767_at L42293 sterol O-acyltransferase 14447 0.21263 2.00 up Mm.196595 Gc 99197_at M55413 group specific component4448 0.21268 1.98 up Mm.7043 Ii 101054_at X00496 Ia-associated invariant chain4449 0.21269 1.36 down Mm.65264 1500010B24Rik 160111_at AI849718 RIKEN cDNA 1500010B24 gene4450 0.21275 1.29 up Mm.41023 1110021E09Rik 97919_at AI837467 RIKEN cDNA 1110021E09 gene4451 0.21288 3.95 up Mm.4587 Ppic 100089_at M74227 peptidylprolyl isomerase C4452 0.21289 1.30 down Mm.29775 0610011D08Rik 160356_at AI851401 RIKEN cDNA 0610011D08 gene4453 0.21294 2.19 up Mm.3896 Dlx2 92332_at M80540 distal-less homeobox 24454 0.21296 1.95 up Mm.200411 Muc10 101139_r_at U37531 mucin 10, submandibular gland salivary mucin4455 0.21298 2.39 up Mm.102140 Jag2 92510_at Y14331 jagged 24456 0.21298 1.97 up Mm.111789 AI848406 95289_r_at AA189811 expressed sequence AI8484064457 0.21306 2.05 up Mm.10984 Slc27a5 92612_at AJ223959 solute carrier family 27 (fatty acid transporter), member 54458 0.21307 1.88 up Mm.2008 Pter 93542_at U28016 phosphotriesterase related4459 0.21309 1.71 up Mm.24959 C77609 95966_at C77609 expressed sequence C776094460 0.21316 1.79 down Mm.24840 C80292 95938_at AA612212 expressed sequence C802924461 0.21316 1.79 up Mm.2437 Bing4-pending 104702_at AI505152 BING4 protein4462 0.21319 1.20 up Mm.20831 Eif2s3y 103674_f_at AJ006584 eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked4463 0.21325 1.52 down Mm.29451 3110057M17Rik 96839_at AI415446 RIKEN cDNA 3110057M17 gene4464 0.21330 2.24 up Mm.24803 Slc26a2 95935_at D42049 solute carrier family 26 (sulfate transporter), member 24465 0.21336 1.77 up Mm.10314 Atp5g2 92570_at AW122482 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subuni4466 0.21337 1.58 up Mm.104747 Igk-V28 101718_f_at U19315 immunoglobulin kappa chain variable 28 (V28)4467 0.21349 1.47 down Mm.2440 Pex7 104706_at U69171 peroxisome biogenesis factor 74468 0.21349 1.81 up Mm.2976 Gp38 104469_at M73748 glycoprotein 384469 0.21350 1.54 down Mm.35089 Prcc 97686_r_at AI604773 papillary renal cell carcinoma (translocation-associated)4470 0.21353 1.86 down Mm.30163 AI195356 160393_at AI853226 EST AI1953564471 0.21355 1.35 down Mm.30072 Cox7a2l 97489_at AI846739 cytochrome c oxidase subunit VIIa polypeptide 2-like4472 0.21362 1.40 down Mm.30119 Sc4mol 160388_at AI848668 sterol-C4-methyl oxidase-like4473 0.21367 5.42 up Mm.15819 Cd68 162173_i_at AV002815 CD68 antigen4474 0.21377 1.72 up Mm.4816 Msx3 92912_at X96518 homeo box, msh-like 34475 0.21379 1.98 up Mm.41746 Rpo2tc1 161508_at AV144516 RNA polymerase II transcriptional coactivator4476 0.21383 2.26 up Mm.197960 C80494 101610_at C80494 expressed sequence C804944477 0.21384 1.29 up Mm.1841 Mrps31 103354_at Z46966 mitochondrial ribosomal protein S314478 0.21385 1.27 down Mm.205996 AA087124 94032_at AI845103 EST AA0871244479 0.21405 1.65 down Mm.15680 H2-Ea 102904_at V00833 histocompatibility 2, class II antigen E alpha4480 0.21405 1.53 up Mm.840 Emu1-pending 161611_f_at AV350190 Emu1 gene4481 0.21405 2.78 up Mm.4511 AI504145 162291_r_at AV377018 expressed sequence AI5041454482 0.21408 1.60 up Mm.7190 Abp1 160923_at AI197481 amiloride binding protein 1 (amine oxidase, copper-containing)4483 0.21408 1.95 up Mm.41770 Fxyd7 99508_at AI844246 FXYD domain-containing ion transport regulator 74484 0.21419 2.06 up Mm.416 Traip 92434_at U77844 TRAF-interacting protein4485 0.21419 3.65 up Mm.3519 Gp5 100740_at Z69595 glycoprotein 5 (platelet)4486 0.21420 2.16 up Mm.10108 Sult1a2 96421_at AF033653 sulfotransferase family 1A, phenol-preferring, member 24487 0.21429 1.86 up Mm.42148 Foxm1 98306_g_at Y11245 forkhead box M14488 0.21431 1.24 down Mm.15755 Sin3a 103011_at L36831 transcriptional regulator, SIN3A (yeast)4489 0.21432 2.90 up Mm.5540 1810054D07Rik 161306_r_at AV058564 RIKEN cDNA 1810054D07 gene4490 0.21438 2.35 up Mm.18635 Rgs10 103384_at AA123848 regulator of G-protein signalling 104491 0.21441 2.14 up Mm.1676 Tyki 103066_at L32973 thymidylate kinase family LPS-inducible member4492 0.21453 2.06 down Mm.4362 Gem 92534_at U10551 GTP binding protein (gene overexpressed in skeletal muscle)4493 0.21455 1.63 up Mm.21873 Ris2 161787_f_at AV363418 retroviral integration site 14494 0.21457 1.43 up Mm.28999 0610033H09Rik 97012_f_at AI838702 RIKEN cDNA 0610033H09 gene4495 0.21460 1.44 down Mm.20964 Gnao 103843_at M36777 guanine nucleotide binding protein, alpha o4496 0.21463 3.81 down Mm.1309 Scn3a 100691_at L42337 sodium channel, voltage-gated, type III, alpha polypeptide4497 0.21471 1.60 up Mm.28386 Knsl5 96168_at AI591702 kinesin-like 5 (mitotic kinesin-like protein 1)4498 0.21472 2.09 up Mm.20870 Rex2 95346_at AF051348 reduced expression 24499 0.21475 2.17 up Mm.2656 Slc17a1 96077_at X77241 solute carrier family 17 vesicular glutamate transporter), member 14500 0.21488 1.63 up Mm.71 Prkdc 93476_at AB011543 protein kinase, DNA activated, catalytic polypeptidePage 50 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description4501 0.21491 2.05 up Mm.181050 Taf15 96554_r_at AW107462 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated facto4502 0.21500 1.24 down Mm.27935 Madh6 104220_at AF010133 MAD homolog 6 (Drosophila)4503 0.21509 2.16 up Mm.7103 Pbx2 92652_at AF030001 pre B-cell leukemia transcription factor 24504 0.21517 1.58 up Mm.202725 AI957095 101423_at AW125560 expressed sequence AI9570954505 0.21534 3.51 up Mm.29477 Scand1 95154_at AI854100 SCAN domain-containing 14506 0.21535 1.43 down Mm.20848 Rfxank 160654_at AI839899 regulatory factor X-associated ankyrin-containing protein4507 0.21539 1.73 up Mm.1283 Scya1 94166_g_at M23501 small inducible cytokine A14508 0.21546 3.29 up Mm.216321 Ate1 97130_at AF079097 arginine-tRNA-protein transferase 14509 0.21550 1.92 up Mm.137268 Hes5 161051_at D32132 hairy and enhancer of split 5, (Drosophila)4510 0.21551 1.19 up Mm.200859 Pafah1b2 160187_at AI846932 platelet-activating factor acetylhydrolase, isoform 1b, alpha2 subunit4511 0.21558 1.88 down Mm.4053 Tln 102732_at AI849746 talin4512 0.21567 1.21 down Mm.22271 Smt3ip1-pending 104287_at AI853807 smt3-specific isopeptidase 14513 0.21572 1.71 up Mm.28161 Zfp36l2 93944_r_at M58564 zinc finger protein 36, C3H type-like 24514 0.21589 1.78 down Mm.1682 Ptpns1 161742_r_at AV317524 protein tyrosine phosphatase, non-receptor type substrate 14515 0.21604 1.32 up Mm.6306 Atp2a3 103935_at AI504474 ATPase, Ca++ transporting, ubiquitous4516 0.21613 2.44 up Mm.154560 Meg3 160172_at Y13832 maternally expressed gene 34517 0.21623 1.28 down Mm.28070 Mm.28070 104231_at AI606915 ESTs, Weakly similar to ROA2 MOUSE HETEROGENEOUS NUCLEAR RIB4518 0.21632 2.33 up Mm.24907 DXErtd11e 95949_at C76382 DNA segment, Chr X, ERATO Doi 11, expressed4519 0.21636 1.22 up Mm.1147 Calm3 92632_at AI842328 calmodulin 34520 0.21639 2.24 up Mm.9970 Aqp8 102200_at AF018952 aquaporin 84521 0.21639 3.89 up Mm.41974 Nkx2-5 97777_at AF091351 NK2 transcription factor related, locus 5 (Drosophila)4522 0.21645 1.30 up Mm.19080 Gtpbp1 161683_r_at AV239949 GTP binding protein 14523 0.21645 2.14 up Mm.4857 Camk2b 100453_at X63615 calcium/calmodulin-dependent protein kinase II, beta4524 0.21658 1.91 up Mm.14438 AU044919 102843_s_at J00475 expressed sequence AU0449194525 0.21663 2.05 up Mm.39472 Mm.39472 162217_r_at AV090583 Mus musculus farnesyl pyrophosphate synthase (Fpps) mRNA, complete cd4526 0.21670 1.61 up Mm.788 Ly6e 101487_f_at U47737 lymphocyte antigen 6 complex, locus E4527 0.21675 2.97 up Mm.3882 Bcl2l 99026_at AF088904 Bcl2-like4528 0.21679 1.27 up Mm.42195 Ruvbl1 160874_r_at AV101823 RuvB-like protein 14529 0.21681 2.68 up Mm.4425 Cldn11 161529_r_at AV230373 claudin 114530 0.21692 2.01 up Mm.131 Hoxa2 102643_at M93148 homeo box A24531 0.21693 1.45 down Mm.4168 Slc12a2 99500_at U13174 solute carrier family 12, member 24532 0.21696 1.76 up Mm.24927 D7Ertd143e 95954_at AA437728 DNA segment, Chr 7, ERATO Doi 143, expressed4533 0.21698 1.29 down Mm.24078 C79732 103706_at AI036406 expressed sequence C797324534 0.21704 2.12 up Mm.5751 Mm.5751 101595_at C78787 ESTs4535 0.21704 1.67 up Mm.42140 Zfp118 92480_f_at AB024004 Zinc finger protein 1184536 0.21724 2.11 up Mm.197936 C79445 94836_at C79445 expressed sequence C794454537 0.21728 1.99 down Mm.7275 Scya25 101403_at AJ249480 small inducible cytokine A254538 0.21735 2.60 up Mm.10081 Gli 103365_s_at AW215551 GLI-Kruppel family member GLI4539 0.21745 1.52 up Mm.4559 Ggtp 100085_at U30509 gamma-glutamyl transpeptidase4540 0.21752 2.06 up Mm.57066 Bcl2l11 99419_g_at AF032459 BCL2-like 11 (apoptosis facilitator)4541 0.21759 2.34 down Mm.212716 Mm.212716 101749_at L43567 Mus musculus mRNA for immunoglobulin heavy chain, mAb 6674542 0.21761 1.39 up Mm.5286 Arbp 101213_at X15267 acidic ribosomal phosphoprotein PO4543 0.21784 2.16 up Mm.2386 Scg3 162237_f_at AV328553 secretogranin III4544 0.21793 1.47 up Mm.196533 2310008D10Rik 95102_at AW123754 RIKEN cDNA 2310008D10 gene4545 0.21795 1.56 up Mm.3904 Fgf15 97721_at AF007268 fibroblast growth factor 154546 0.21795 1.47 up Mm.116 H2-Oa 103828_at AF100956 histocompatibility 2, O region alpha locus4547 0.21802 1.49 down Mm.21295 AU044865 103893_at AW048781 expressed sequence AU0448654548 0.21807 3.06 up Mm.4704 Foxg1 161049_at U36760 forkhead box G14549 0.21809 1.75 up Mm.161 Brca2 102911_at U89652 breast cancer 24550 0.21811 2.43 up Mm.2537 Ncoa2 96508_at U39060 nuclear receptor coactivator 24551 0.21816 1.20 down Mm.13886 Sui1-rs1 92855_at Z50159 suppressor of initiator codon mutations, related sequence 1 (S. cerevisiae)4552 0.21816 2.00 down Mm.3537 Ren1 161269_i_at AV319451 renin 1 structural4553 0.21820 2.40 up Mm.14547 Mm.14547 102833_at AW046220 ESTs, Weakly similar to A39634 probable cell cycle control protein crn - fruit4554 0.21834 7.89 up Mm.980 Tnc 101993_at X56304 tenascin C4555 0.21836 1.57 up Mm.7087 Rab5ep-pending 102724_at AI608324 rabaptin 54556 0.21836 1.44 down Mm.1059 Map2k1 92585_at L02526 mitogen activated protein kinase kinase 14557 0.21846 1.98 up Mm.1904 Ttk 103201_at M86377 Ttk protein kinase4558 0.21853 2.36 up Mm.22213 5730414A08Rik 104276_at AA983101 RIKEN cDNA 5730414A08 gene4559 0.21867 1.36 up Mm.43162 0710008D09Rik 161338_i_at AV124842 RIKEN cDNA 0710008D09 gene4560 0.21868 2.11 up Mm.1013 Lig1 162004_i_at AV242483 ligase I, DNA, ATP-dependent4561 0.21877 1.81 up Mm.175310 H2-Aa 101314_at D64112 histocompatibility 2, class II antigen A, alpha4562 0.21878 1.84 up Mm.138866 Apoe 95356_at D00466 apolipoprotein E4563 0.21889 1.71 up Mm.27592 Ncoa6 95525_at AI850793 nuclear receptor coactivator 64564 0.21898 1.99 up Mm.1051 Casp1 102064_at L28095 caspase 14565 0.21898 1.29 up Mm.29546 Baf53a-pending 95659_at AF041476 BRG1/brm-associated factor 53A4566 0.21902 1.56 up Mm.21135 D12Ertd7e 160957_at AI156978 DNA segment, Chr 12, ERATO Doi 7, expressed4567 0.21917 1.55 down Mm.1418 Scn1b 102808_at L48687 sodium channel, voltage-gated, type I, beta polypeptide4568 0.21923 1.76 up Mm.21902 AA420405 95360_at AA259683 expressed sequence AA4204054569 0.21928 1.39 down Mm.29353 2010110M21Rik 95105_at AI847697 RIKEN cDNA 2010110M21 gene4570 0.21930 1.75 up Mm.56895 D17H6S56E-3 92307_at AF109905 DNA segment, Chr 17, human D6S56E 34571 0.21931 1.55 up Mm.22574 Csf1r 161832_r_at AV028184 colony stimulating factor 1 receptor4572 0.21933 2.93 up Mm.4441 Epb7.2 100052_at X91043 erythrocyte protein band 7.24573 0.21935 1.59 up Mm.7883 Apc 101447_at M88127 adenomatosis polyposis coli4574 0.21939 3.86 up Mm.27317 Coro1a 96648_at AW122039 coronin, actin binding protein 1A4575 0.21942 1.69 up Mm.2874 Cbg 96227_at X70533 corticosteroid binding globulin4576 0.21944 1.46 up Mm.15343 Casq2 93053_at AF068244 calsequestrin 24577 0.21954 1.99 up Mm.56581 2610019F01Rik 161011_at AI595313 RIKEN cDNA 2610019F01 gene4578 0.21959 1.56 up Mm.22317 8430410A17Rik 160684_at AA930519 RIKEN cDNA 8430410A17 gene4579 0.21962 2.02 up Mm.206790 Cttn 94055_at U03184 cortactin4580 0.21962 2.03 up Mm.4860 Ptprl 162376_r_at AV243403 protein tyrosine phosphatase, receptor type, L4581 0.21986 1.54 up Mm.33202 2410018A17Rik 97539_at AI854416 RIKEN cDNA 2410018A17 gene4582 0.21987 1.85 up Mm.175848 S100a11 98600_at U41341 S100 calcium binding protein A11 (calizzarin)4583 0.21998 1.17 down Mm.22333 Rpn1 161400_f_at AV276050 ribophorin I4584 0.22001 2.43 up Mm.196396 Tuba1 100342_i_at M28729 tubulin alpha 14585 0.22004 1.29 down Mm.16553 Nedd4a 93101_s_at U96635 neural precursor cell expressed, developmentally down-regulated gene 4a4586 0.22012 2.08 up Mm.200563 AI854630 161119_at AI854630 expressed sequence AI8546304587 0.22021 1.35 down Mm.3438 Lmna 98059_s_at D49733 lamin A4588 0.22023 1.72 up Mm.16479 2310076D10Rik 160369_at AI849109 RIKEN cDNA 2310076D10 gene4589 0.22028 1.64 up Mm.24936 C76977 95958_at AA667702 expressed sequence C769774590 0.22035 2.01 up Mm.4546 Crhr2 162152_r_at AV332164 corticotropin releasing hormone receptor 2Page 51 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description4591 0.22041 1.53 up Mm.1238 Csf3 94142_at M13926 colony stimulating factor 3 (granulocyte)4592 0.22047 1.89 up Mm.12964 Nsd1 92827_at AF064553 nuclear receptor-binding SET-domain protein 14593 0.22055 2.04 up Mm.27887 Laf4l 95888_at AI507266 lymphoid nuclear protein related to AF4-like4594 0.22057 2.22 up Mm.21881 TOB3 104103_at AI838481 TOB34595 0.22061 2.22 up Mm.4715 Ptpro 100427_at U37465 protein tyrosine phosphatase, receptor type, O4596 0.22070 1.40 down Mm.989 Gna11 102196_at U37413 guanine nucleotide binding protein, alpha 114597 0.22085 1.43 up Mm.30152 Mrpl33 96916_at AW046793 mitochondrial ribosomal protein L334598 0.22091 2.54 up Mm.20452 Ern2 95329_at AF071777 endoplasmic reticulum (ER) to nucleus signalling 24599 0.22117 2.96 up Mm.738 Col4a1 101093_at M15832 procollagen, type IV, alpha 14600 0.22121 1.57 up Mm.3374 Efnb1 98407_at U07602 ephrin B14601 0.22127 1.27 up Mm.183025 Rbm14 100138_f_at X52102 RNA binding motif protein 144602 0.22148 1.43 down Mm.29629 AI480459 97353_at AI837497 expressed sequence AI4804594603 0.22150 1.82 up Mm.954 2410153K17Rik 160940_at AI550400 RIKEN cDNA 2410153K17 gene4604 0.22151 1.57 up Mm.14287 Hspa1l 102714_at L27086 heat shock 70kD protein 1-like4605 0.22152 1.39 down Mm.42154 Trif-pending 100979_at AW209763 Trif gene4606 0.22159 1.68 up Mm.1976 Cdh15 103213_at AJ245402 cadherin 154607 0.22163 1.19 up Mm.27182 1110031I02Rik 160512_at AA606318 RIKEN cDNA 1110031I02 gene4608 0.22169 1.69 down Mm.27665 2010015J01Rik 161838_f_at AV042598 RIKEN cDNA 2010015J01 gene4609 0.22170 1.82 up Mm.4791 Ereg 98802_at D30782 epiregulin4610 0.22171 2.38 up Mm.147824 Abcc8 103274_at AA967624 ATP-binding cassette, sub-family C (CFTR/MRP), member 84611 0.22182 1.62 up Mm.33640 Mm.33640 97115_at AI507107 ESTs, Weakly similar to POL1_HUMAN RETROVIRUS-RELATED POL POL4612 0.22182 2.21 up Mm.27085 9430025F20Rik 160733_at AI035317 RIKEN cDNA 9430025F20 gene4613 0.22183 1.55 up Mm.39053 Ap2b1 99515_at AW046293 adaptor-related protein complex 2, beta 1 subunit4614 0.22183 1.77 up Mm.8854 Agt 101887_at AF045887 angiotensinogen4615 0.22185 1.50 down Mm.26973 2810453H10Rik 104022_at AA590060 RIKEN cDNA 2810453H10 gene4616 0.22186 1.75 up Mm.42043 AJ242955 98281_at AB028868 hypothetical protein, P4(21)n gene4617 0.22188 1.57 up Mm.3572 1110033J19Rik 98148_at AA028728 RIKEN cDNA 1110033J19 gene4618 0.22191 1.30 down Mm.37516 Dnajb11 98572_at AW122551 DnaJ (Hsp40) homolog, subfamily B, member 114619 0.22194 1.52 up Mm.4614 4921519L13Rik 92708_at AI843597 RIKEN cDNA 4921519L13 gene4620 0.22202 1.54 down Mm.40984 Mecp2 99465_at AJ132922 methyl CpG binding protein 24621 0.22221 2.49 up Mm.28172 Phemx 104239_at AW208513 pan hematopoietic expression4622 0.22222 3.88 up Mm.5245 Sele 99333_at M80778 selectin, endothelial cell4623 0.22227 1.81 up Mm.200516 Pitpnb 102696_s_at AI747899 phosphotidylinositol transfer protein, beta4624 0.22233 1.32 up Mm.18834 2310058A11Rik 103413_at AI021091 RIKEN cDNA 2310058A11 gene4625 0.22234 2.30 up Mm.14514 V2r14 100687_f_at AF011424 vomeronasal 2, receptor, 144626 0.22237 1.33 up Mm.17035 AB041568 93256_at AI853728 hypothetical protein, MNCb-12134627 0.22244 1.87 up Mm.1256 Zfp239 102411_at M32057 zinc finger protein 2394628 0.22245 1.30 down Mm.29159 0610011E17Rik 95059_at AW047399 RIKEN cDNA 0610011E17 gene4629 0.22251 1.52 up Mm.55843 Ppp1r2 95681_f_at AW049584 protein phosphatase 1, regulatory (inhibitor) subunit 24630 0.22256 2.84 up Mm.4083 Sema3b 99460_at X85990 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (se4631 0.22258 1.57 up Mm.3054 Idua 104500_at L34111 alpha-L-iduronidase4632 0.22276 1.92 up Mm.24640 Grb10 95450_at AI852006 growth factor receptor bound protein 104633 0.22277 1.41 up Mm.21686 C80633 93978_at AI853240 expressed sequence C806334634 0.22286 1.22 down Mm.14638 Gabarapl1 93011_at AW123904 gamma-aminobutyric acid (GABA(A)) receptor-associated protein-like 14635 0.22292 1.53 down Mm.8473 Adh3 93695_at U20257 alcohol dehydrogenase 3 complex4636 0.22300 1.92 up Mm.5348 1700010P14Rik 161240_f_at AV270995 RIKEN cDNA 1700010P14 gene4637 0.22301 2.52 up Mm.5104 Nfic 93006_at Y07693 nuclear factor I/C4638 0.22302 1.55 up Mm.24426 Sec23a 93711_at D12713 SEC23A (S. cerevisiae)4639 0.22304 2.00 up Mm.24769 Ifi47 104750_at M63630 interferon gamma inducible protein, 47 kDa4640 0.22307 1.48 up Mm.29549 Hes6 97334_at AW048812 hairy and enhancer of split 6, (Drosophila)4641 0.22327 1.39 up Mm.34650 Palm 98454_at Y14771 paralemmin4642 0.22338 1.54 up Mm.203866 AA589382 160255_at AA657044 expressed sequence AA5893824643 0.22340 1.43 up Mm.24818 Mm.24818 95937_at AI429010 ESTs4644 0.22346 1.47 down Mm.2344 Gnb1 94854_g_at U29055 guanine nucleotide binding protein, beta 14645 0.22346 1.77 up Mm.6667 1210002E11Rik 100975_f_at AI854882 RIKEN cDNA 1210002E11 gene4646 0.22359 1.34 up Mm.21156 C77440 93762_at AI841493 expressed sequence C774404647 0.22360 2.05 up Mm.21855 Pglyrp 162475_f_at AV092014 peptidoglycan recognition protein4648 0.22374 2.46 up Mm.5106 Neurod6 98857_at U29086 neurogenic differentiation 64649 0.22376 1.31 up Mm.20895 Nrip1 103288_at AF053062 nuclear receptor interacting protein 14650 0.22377 2.07 up Mm.8877 Hsd17b2 101891_at Y09517 hydroxysteroid 17-beta dehydrogenase 24651 0.22394 2.62 up Mm.3107 Nfatc3 102050_at AI846984 nuclear factor of activated T-cells, cytoplasmic 34652 0.22396 1.50 up Mm.25582 Mm.25582 103959_at AI605405 ESTs4653 0.22405 1.43 up Mm.23018 2810423O19Rik 104525_at AW124812 RIKEN cDNA 2810423O19 gene4654 0.22408 1.86 up Mm.1939 Mm.1939 95294_at AI605509 ESTs4655 0.22410 1.37 up Mm.10702 Cacybp 92596_at U97327 calcyclin binding protein4656 0.22432 1.63 down Mm.36834 C77823 103316_at AI642561 expressed sequence C778234657 0.22442 1.45 down Mm.23118 1300008P06Rik 161770_f_at AV341577 RIKEN cDNA 1300008P06 gene4658 0.22442 1.78 up Mm.28207 D4Wsu132e 161425_r_at AV296797 DNA segment, Chr 4, Wayne State University 132, expressed4659 0.22449 1.52 up Mm.200180 AI607873 92251_f_at AA960657 expressed sequence AI6078734660 0.22453 1.22 up Mm.11112 2210013K02Rik 92622_at AI851064 RIKEN cDNA 2210013K02 gene4661 0.22470 1.29 up Mm.28709 D11Wsu78e 96220_at AW123157 DNA segment, Chr 11, Wayne State University 78, expressed4662 0.22473 1.28 down Mm.19947 Map2k5 103592_at AB019374 mitogen activated protein kinase kinase 54663 0.22477 1.48 down Mm.182328 4921516M08Rik 104356_at AI465543 RIKEN cDNA 4921516M08 gene4664 0.22493 2.49 up Mm.6890 2010107K23Rik 160917_r_at AA710297 RIKEN cDNA 2010107K23 gene4665 0.22496 2.77 up Mm.57233 Rasgrf2 102572_at U67326 RAS protein-specific guanine nucleotide-releasing factor 24666 0.22496 1.85 up Mm.41573 Fmod 161373_r_at AV240231 fibromodulin4667 0.22505 1.24 up Mm.195898 Pbp 162299_f_at AV029120 phosphatidylethanolamine binding protein4668 0.22511 1.48 down Mm.29262 Apel-pending 100392_at AB023494 apelin4669 0.22516 1.69 down Mm.9745 Ldh2 101990_at X51905 lactate dehydrogenase 2, B chain4670 0.22526 2.78 up Mm.212716 Mm.212716 101752_f_at Z22111 Mus musculus mRNA for immunoglobulin heavy chain, mAb 6674671 0.22534 1.33 down Mm.22547 Asah1 94282_at AW124297 N-acylsphingosine amidohydrolase 14672 0.22535 3.94 up Mm.36742 Dcsn 98976_at AJ242912 decysin4673 0.22536 1.70 up Mm.14318 AI324046 102722_g_at D14625 expressed sequence AI3240464674 0.22548 1.57 up Mm.12862 Pcdh12 94169_at Y08715 protocadherin 124675 0.22555 1.34 down Mm.29994 Eno3 96344_at X61600 enolase 3, beta muscle4676 0.22557 1.58 up Mm.28764 D7Ertd486e 93449_at AA675341 DNA segment, Chr 7, ERATO Doi 486, expressed4677 0.22566 2.17 up Mm.5324 A030009H04Rik 161553_i_at AV252253 RIKEN cDNA A030009H04 gene4678 0.22569 1.32 up Mm.20288 Gsr 160646_at AI851983 glutathione reductase 14679 0.22573 1.40 down Mm.28604 Mm.28604 104395_at AW121826 ESTs4680 0.22575 1.28 up Mm.209 2010309E21Rik 160955_at AW124904 RIKEN cDNA 2010309E21 genePage 52 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description4681 0.22576 2.25 up Mm.890 Hoxb1 93888_at X53063 homeo box B14682 0.22587 1.45 up Mm.77432 Txnip 160548_at AI098675 thioredoxin interacting protein4683 0.22590 1.46 up Mm.33263 H2-D1 97540_f_at M69069 histocompatibility 2, D region locus 14684 0.22591 2.56 up Mm.1856 Marco 102974_at U18424 macrophage receptor with collagenous structure4685 0.22597 1.65 up Mm.20213 4933425L11Rik 103613_at AA144642 RIKEN cDNA 4933425L11 gene4686 0.22604 1.29 down Mm.13912 Jtb 102790_at AB016490 jumping translocation breakpoint4687 0.22611 1.83 up Mm.4406 Mmp9 162369_f_at AV239570 matrix metalloproteinase 94688 0.22626 1.16 up Mm.1508 Bzrp 93042_at D21207 benzodiazepine receptor, peripheral4689 0.22628 2.59 up Mm.35844 Gas5 101885_at X59728 growth arrest specific 54690 0.22632 1.73 up Mm.136107 AI585872 95911_at AI585872 expressed sequence AI5858724691 0.22634 1.34 down Mm.3880 Ddx19 99025_at L25125 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 194692 0.22640 2.41 up Mm.1332 Gpx5 161986_f_at AV381732 glutathione peroxidase 54693 0.22640 1.53 up Mm.196352 Krt2-6b 94316_at AB012042 keratin complex 2, basic, gene 6b4694 0.22647 1.51 up Mm.88826 Ora16 96986_at AB030896 gene for odorant receptor A164695 0.22653 1.77 down Mm.26171 Lce-pending 94418_at AI839004 long chain fatty acyl elongase4696 0.22655 1.87 up Mm.742 Dmd 93623_at U56724 dystrophin, muscular dystrophy4697 0.22659 1.94 up Mm.970 Ckmt1 161495_r_at AV091448 creatine kinase, mitochondrial 1, ubiquitous4698 0.22659 1.92 down Mm.29095 C9 104424_at X05475 complement component 94699 0.22668 1.58 up Mm.41989 Aloxe3 97784_at Y14695 arachidonate lipoxygenase 34700 0.22679 2.04 up Mm.45765 2810417H13Rik 161974_r_at AV372058 RIKEN cDNA 2810417H13 gene4701 0.22681 1.27 up Mm.660 Mm.660 100965_at AA108893 ESTs4702 0.22693 1.29 down Mm.176369 Sox15 160805_s_at AB025354 SRY-box containing gene 154703 0.22711 2.16 up Mm.44016 C77137 102140_at C77137 expressed sequence C771374704 0.22713 2.03 up Mm.1148 5830431A10Rik 94136_at AA168476 RIKEN cDNA 5830431A10 gene4705 0.22715 1.43 down Mm.28083 Cd164 97312_at AB014464 CD164 antigen4706 0.22716 1.44 up Mm.20365 Gp1bb 160649_at AB001419 glycoprotein Ib, beta polypeptide4707 0.22717 1.97 down Mm.3396 Zfp42 98414_at M97812 zinc finger protein 424708 0.22734 1.56 up Mm.31387 Nr5a1 100701_r_at AB000490 nuclear receptor subfamily 5, group A, member 14709 0.22737 1.88 up Mm.5399 AI506816 93180_at AI553553 expressed sequence AI5068164710 0.22752 1.54 down Mm.3901 Mst1r 97719_at X74736 macrophage stimulating 1 receptor (c-met-related tyrosine kinase)4711 0.22758 1.29 up Mm.45683 1500034E06Rik 161860_f_at AV062608 RIKEN cDNA 1500034E06 gene4712 0.22776 3.80 up Mm.43831 Lgals1 99669_at X15986 lectin, galactose binding, soluble 14713 0.22790 1.35 up Mm.21421 AI463102 103911_at AI851573 EST AI4631024714 0.22810 1.50 up Mm.4339 Lama5 99931_at U37501 laminin, alpha 54715 0.22820 1.44 up Mm.25171 Fzd8 99415_at U43321 frizzled homolog 8 (Drosophila)4716 0.22852 1.85 up Mm.27444 1810034K18Rik 162096_at AV357276 RIKEN cDNA 1810034K18 gene4717 0.22854 1.44 down Mm.6441 Dncic2 100603_at AF063231 dynein, cytoplasmic, intermediate chain 24718 0.22858 1.96 down Mm.2003 Mdm1 103599_at M20824 transformed mouse 3T3 cell double minute 14719 0.22860 2.15 up Mm.12906 Ddc 160074_at AF071068 dopa decarboxylase4720 0.22862 1.45 up Mm.32990 Pigm 96527_at AI596614 phosphatidylinositol glycan, class M4721 0.22866 1.36 up Mm.27834 2610202O07Rik 160757_at AA940005 RIKEN cDNA 2610202O07 gene4722 0.22866 1.37 up Mm.16925 AI848392 93248_at AI050598 expressed sequence AI8483924723 0.22869 1.16 down Mm.2760 Zipro1 96707_at D10630 zinc finger proliferation 14724 0.22877 1.75 up Mm.35235 R74626 101210_at R74626 expressed sequence R746264725 0.22879 2.00 up Mm.14172 Abcb4 94733_at J03398 ATP-binding cassette, sub-family B (MDR/TAP), member 44726 0.22880 1.33 down Mm.29865 1110020C13Rik 96278_at AI846553 RIKEN cDNA 1110020C13 gene4727 0.22886 1.47 up Mm.14063 Rsdr1-pending 102797_at X95281 retinal short-chain dehydrogenase/reductase 14728 0.22899 1.31 up Mm.16554 Hdh 102927_s_at L23312 Huntington disease gene homolog4729 0.22899 1.63 up Mm.33376 Shoc2 104216_at AF068921 soc-2 (suppressor of clear) homolog (C. elegans)4730 0.22900 1.19 up Mm.30240 Mrpl52 97443_at AI850850 mitochondrial ribosomal protein L524731 0.22904 1.90 up Mm.12935 Tnfrsf17 94190_at AF061505 tumor necrosis factor receptor superfamily, member 174732 0.22905 2.35 up Mm.16106 C4 162390_r_at AV259769 complement component 4 (within H-2S)4733 0.22907 1.29 down Mm.2792 Ptgs1 95597_at M34141 prostaglandin-endoperoxide synthase 14734 0.22909 2.79 up Mm.3147 Ripk1 97091_at U25995 receptor (TNFRSF)-interacting serine-threonine kinase 14735 0.22914 1.61 up Mm.202771 AI507533 162160_at AV027702 expressed sequence AI5075334736 0.22920 1.41 up Mm.3379 Shmt1 98459_at AA913994 serine hydroxymethyl transferase 1 (soluble)4737 0.22926 1.46 down Mm.3705 P4ha2 98983_at U16163 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), a4738 0.22941 1.52 up Mm.4351 Avpr1a 92532_at D49730 arginine vasopressin receptor 1A4739 0.22947 1.72 up Mm.87865 Cma2 95806_f_at M68899 chymase 2, mast cell4740 0.22961 1.76 up Mm.20313 0710001P09Rik 93561_at AI844709 RIKEN cDNA 0710001P09 gene4741 0.22962 1.49 down Mm.4789 Ank1 100439_i_at U76758 ankyrin 1, erythroid4742 0.22964 1.49 down Mm.9699 Pmm2 101949_at AF043514 phosphomannomutase 24743 0.22968 1.61 up Mm.27723 Fem1a 97213_at AF064447 feminization 1 homolog a (C. elegans)4744 0.22980 1.32 up Mm.5831 Abce1 100568_at U90446 ATP-binding cassette, sub-family E (OABP), member 14745 0.22983 1.13 down Mm.29321 9430098E02Rik 104444_at AA689927 RIKEN cDNA 9430098E02 gene4746 0.22985 1.38 down Mm.25231 4932441P04Rik 94356_at AI593074 RIKEN cDNA 4932441P04 gene4747 0.22995 2.23 up Mm.6276 U2af1-rs2 93398_at D45205 U2 small nuclear ribonucleoprotein auxiliary factor (U2AF), 35 kDa, related s4748 0.23002 1.43 down Mm.2623 Serpinb6 96060_at U25844 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 64749 0.23006 2.47 up Mm.12919 Igf2bp1 102627_at AF061569 insulin-like growth factor 2, binding protein 14750 0.23007 1.32 up Mm.24007 2010300F21Rik 94980_at AI006319 RIKEN cDNA 2010300F21 gene4751 0.23020 1.27 up Mm.43580 Minpp1 99640_at AW045481 multiple inositol polyphosphate histidine phosphatase 14752 0.23024 1.84 up Mm.7387 Rpo1-4 161379_at AV245705 RNA polymerase 1-4 (194 kDa subunit)4753 0.23029 1.62 up Mm.104295 Slc10a1 100339_at U95131 solute carrier family 10 (sodium/bile acid cotransporter family), member 14754 0.23029 2.93 up Mm.2450 Rbp1 104716_at X60367 retinol binding protein 1, cellular4755 0.23032 1.38 down Mm.24338 BB101783 104630_at AA914114 expressed sequence BB1017834756 0.23044 2.37 up Mm.479 Mybl1 92902_at L35261 myeloblastosis oncogene-like 14757 0.23049 1.56 up Mm.4827 F7 161458_at AV298640 coagulation factor VII4758 0.23056 1.41 up Mm.42038 Spry4 98278_at AB019280 sprouty homolog 4 (Drosophila)4759 0.23060 1.54 up Mm.24886 4833420N02Rik 160722_at AW060526 RIKEN cDNA 4833420N02 gene4760 0.23061 1.33 up Mm.195204 D2Ertd303e 97083_at AA600468 DNA segment, Chr 2, ERATO Doi 303, expressed4761 0.23066 2.39 up Mm.24741 Slc1a1 104747_at U73521 solute carrier family 1, member 14762 0.23067 2.97 up Mm.45494 Gcg 94633_at Z46845 glucagon4763 0.23071 2.31 up Mm.39496 Zfpm2 92355_at AF107306 zinc finger protein, multitype 24764 0.23104 1.35 up Mm.18203 Eed 103342_at U78103 embryonic ectoderm development4765 0.23136 2.21 up Mm.6904 Fgfr3 160919_r_at M81342 fibroblast growth factor receptor 34766 0.23140 1.78 up Mm.204652 Mm.204652 93199_at Y11009 M.musculus mRNA for L41 ribosomal like-protein4767 0.23140 1.28 down Mm.27947 2410007D12Rik 97276_at AI853425 RIKEN cDNA 2410007D12 gene4768 0.23150 1.34 up Mm.34133 Cd6 92204_at U12434 CD6 antigen4769 0.23171 1.96 up Mm.4397 AA545190 98357_at AA545180 EST AA5451904770 0.23179 1.27 down Mm.4941 Ndpp1 100472_at D10727 NPC derived proline rich protein 1Page 53 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description4771 0.23181 1.92 up Mm.3152 Ppicap 97507_at X67809 peptidylprolyl isomerase C-associated protein4772 0.23188 1.64 down Mm.181562 Adrm1 97875_at AW123694 adhesion regulating molecule 14773 0.23194 1.52 down Mm.202664 AW493766 92871_at AW121840 expressed sequence AW4937664774 0.23200 1.17 up Mm.14585 Lsm4-pending 93008_at AW120557 U6 snRNA-associated SM-like protein 44775 0.23205 1.81 up Mm.25004 Mm.25004 95877_at C78858 EST, Moderately similar to Unknown gene product [H.sapiens]4776 0.23211 1.49 down Mm.14616 Pqbp1 93010_at AJ250406 polyglutamine binding protein 14777 0.23227 1.66 down Mm.7760 Arl6 101439_at AW122716 ADP-ribosylation-like 64778 0.23247 1.66 up Mm.26954 Hoxa11 104021_at U20371 homeo box A114779 0.23254 1.44 down Mm.30991 Phkg2 97971_at AI852148 5phosphorylase kinase, gamma 2 (<strong>test</strong>is)4780 0.23262 1.65 up Mm.4201 Krt1-12 97788_at U02880 keratin complex 1, acidic, gene 124781 0.23271 1.33 up Mm.8975 Itch 101905_at AF037454 itchy4782 0.23280 1.56 up Mm.57052 Grbp 99414_at U43194 GTP-rho binding protein 14783 0.23280 1.73 up Mm.15105 Inpp5d 102884_at U51742 inositol polyphosphate-5-phosphatase, 145 kDa4784 0.23281 1.53 down Mm.11218 Mm.11218 102346_at AI747755 Mus musculus, Similar to excision repair cross-complementing rodent repair4785 0.23283 1.17 down Mm.28189 Spec1-pending 97817_at AW121136 small protein effector 1 of Cdc424786 0.23283 1.60 up Mm.52270 C78948 103132_at C78948 expressed sequence C789484787 0.23296 1.41 up Mm.58771 Rab14 95686_at AW047017 RAB14, member RAS oncogene family4788 0.23297 1.40 up Mm.6957 Rps3a 101664_at Z83368 ribosomal protein S3a4789 0.23305 1.42 up Mm.21679 1300002F13Rik 93975_at AI853531 RIKEN cDNA 1300002F13 gene4790 0.23313 3.01 up Mm.3448 Il5ra 97128_at D90205 interleukin 5 receptor, alpha4791 0.23324 1.57 up Mm.16373 H2-DMa 93092_at U35323 histocompatibility 2, class II, locus DMa4792 0.23328 1.85 up Mm.5183 Bach1 93142_at D86603 BTB and CNC homology 14793 0.23328 1.54 up Mm.151104 D530030D03Rik 94385_at AW049125 RIKEN cDNA D530030D03 gene4794 0.23348 2.35 up Mm.1532 Mm.1532 161094_r_at AW046118 Mus musculus, clone MGC:31332 IMAGE:4224574, mRNA, complete cds4795 0.23353 1.31 up Mm.21758 Cyp2e1 93996_at X01026 cytochrome P450, 2e1, ethanol inducible4796 0.23355 1.78 up Mm.10100 Trrp4 94100_s_at AF011543 transient receptor protein 44797 0.23360 2.48 up Mm.29391 1110007F23Rik 161962_f_at AV366654 RIKEN cDNA 1110007F23 gene4798 0.23376 2.61 up Mm.41612 2900051M01Rik 92944_at AW048549 RIKEN cDNA 2900051M01 gene4799 0.23389 1.29 up Mm.21549 Cryac 160139_at AI848798 crystallin, alpha C4800 0.23391 1.59 up Mm.56904 Kcnd3 99371_at AF107781 potassium voltage-gated channel, Shal-related family, member 34801 0.23392 1.70 up Mm.8702 Cxadr 93725_at U90715 coxsackievirus and adenovirus receptor4802 0.23393 1.35 down Mm.196464 Gnai2 99596_f_at M13963 guanine nucleotide binding protein, alpha inhibiting 24803 0.23400 1.29 up Mm.4891 Dgsc 161247_f_at AV313342 DiGeorge syndrome gene c4804 0.23402 1.68 up Mm.1563 Siat7c 102899_at Y11342 sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-ace4805 0.23426 2.15 up Mm.30069 1200003J11Rik 96875_r_at AI841410 RIKEN cDNA 1200003J11 gene4806 0.23441 1.39 up Mm.28537 Scamp2 162039_f_at AV373571 secretory carrier membrane protein 24807 0.23453 1.68 up Mm.200608 D14Ucla3 161294_f_at AV003873 DNA segment, Chr 14, University of California at Los Angeles 34808 0.23456 1.79 up Mm.180687 0610007P22Rik 103372_at AW046508 RIKEN cDNA 0610007P22 gene4809 0.23462 1.33 down Mm.27861 P2rx4 95586_at AF089751 purinergic receptor P2X, ligand-gated ion channel 44810 0.23466 2.98 up Mm.38470 Dnase1 92865_at AJ000062 deoxyribonuclease I4811 0.23468 1.75 up Mm.5135 Grik2 98864_s_at D10054 glutamate receptor, ionotropic, kainate 2 (beta 2)4812 0.23476 1.55 up Mm.46801 Mm.46801 96992_r_at X51742 M.musculus mRNA (2F7) for IgA V-D-J-heavy chain4813 0.23477 1.70 down Mm.4105 Csnb 99130_at X04490 casein beta4814 0.23484 2.05 up Mm.14301 Oas1a 99383_at M63849 2'-5' oligoadenylate synthetase 1A4815 0.23484 1.32 down Mm.157101 C330007P06Rik 103695_f_at AW047329 RIKEN cDNA C330007P06 gene4816 0.23485 1.48 up Mm.57192 Cyp21a1 100609_at AF049850 cytochrome P450, 21, steroid 21 hydroxylase4817 0.23500 2.02 up Mm.159648 5830413L19Rik 98373_at AI462516 RIKEN cDNA 5830413L19 gene4818 0.23514 1.25 down Mm.30145 Enpp5 104763_at AW048581 ectonucleotide pyrophosphatase/phosphodiesterase 54819 0.23514 3.19 up Mm.29487 1810027D10Rik 102104_f_at AI504305 RIKEN cDNA 1810027D10 gene4820 0.23520 1.73 up 101756_f_at AJ0055694821 0.23524 1.46 up Mm.154195 2810417D08Rik 93437_f_at AI850509 RIKEN cDNA 2810417D08 gene4822 0.23526 1.43 down Mm.2445 Acadl 95425_at U21489 acetyl-Coenzyme A dehydrogenase, long-chain4823 0.23548 1.32 up Mm.3406 Tcfe2a 98040_at D16631 transcription factor E2a4824 0.23561 2.89 up Mm.25089 Mm.25089 162132_f_at AV342672 ESTs, Weakly similar to MAF2 MOUSE TRANSCRIPTION FACTOR MAF2 [4825 0.23563 2.19 up Mm.195831 Cetn1 99995_at D16301 centrin 14826 0.23565 1.91 down Mm.37221 AV208457 97685_at AI666301 expressed sequence AV2084574827 0.23573 1.32 up Mm.25610 4932431F02Rik 96577_i_at AI853019 RIKEN cDNA 4932431F02 gene4828 0.23573 1.23 down Mm.7286 Ctbp1 101081_at AJ010483 C-terminal binding protein 14829 0.23576 2.12 up Mm.144308 Igh-1 98776_at AF035203 immunoglobulin heavy chain 1 (serum IgG2a)4830 0.23583 1.60 down Mm.2045 Mras 103653_at AB004879 muscle and microspikes RAS4831 0.23602 1.38 up Mm.151483 2900026H06Rik 92691_at AW048155 RIKEN cDNA 2900026H06 gene4832 0.23612 1.24 down Mm.18972 2410174K12Rik 93365_s_at AI838149 RIKEN cDNA 2410174K12 gene4833 0.23613 1.68 up Mm.5085 Six4 93001_at D50418 sine oculis-related homeobox 4 homolog (Drosophila)4834 0.23616 1.20 down Mm.7066 C79672 101057_at AW121180 expressed sequence C796724835 0.23618 2.26 up Mm.215396 Mm.215396 92318_at AA544871 ESTs4836 0.23621 1.73 up Mm.27276 Mm.27276 104177_at AA204579 ESTs4837 0.23622 1.41 up Mm.200415 Fbs 97410_at AW049193 fibrosin4838 0.23622 1.35 down Mm.144218 1500026A19Rik 95590_at AA615951 RIKEN cDNA 1500026A19 gene4839 0.23630 1.85 up Mm.11480 2810470K21Rik 97703_at AI427631 RIKEN cDNA 2810470K21 gene4840 0.23647 2.13 up Mm.197519 5031415C07Rik 93779_at AA261092 RIKEN cDNA 5031415C07 gene4841 0.23653 1.76 up 96965_at M165124842 0.23662 3.30 up Mm.24920 Clecsf8 95951_at AF061272 C-type (calcium dependent, carbohydrate recognition domain) lectin, superfa4843 0.23666 1.36 up Mm.159327 5830410O09Rik 97944_f_at AF099808 RIKEN cDNA 5830410O09 gene4844 0.23672 3.57 up Mm.212716 Mm.212716 100375_i_at AF025445 Mus musculus mRNA for immunoglobulin heavy chain, mAb 6674845 0.23678 1.24 up Mm.215129 Mm.215129 162245_f_at AV332872 ESTs4846 0.23698 1.77 up Mm.4890 Fau 100141_at X65922 Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expresse4847 0.23703 1.50 up Mm.200389 4833420O05Rik 160605_s_at AI157260 RIKEN cDNA 4833420O05 gene4848 0.23714 1.60 down Mm.28561 Prkcz 96198_at M94632 protein kinase C, zeta4849 0.23720 1.66 up Mm.200459 0610005C13Rik 104617_at AI042964 RIKEN cDNA 0610005C13 gene4850 0.23745 1.34 down Mm.1706 AA409185 93257_at AW048287 expressed sequence AA4091854851 0.23754 1.40 down Mm.17918 1110063F24Rik 160619_at AI843727 RIKEN cDNA 1110063F24 gene4852 0.23767 1.28 down Mm.889 Rac1 101555_at X57277 RAS-related C3 botulinum substrate 14853 0.23769 1.26 down Mm.30003 2400001E08Rik 96352_at AI848845 RIKEN cDNA 2400001E08 gene4854 0.23770 2.29 up Mm.3096 Gja7 104635_r_at X63100 gap junction membrane channel protein alpha 74855 0.23778 2.11 up Mm.56944 Pou3f3 101305_at M88299 POU domain, class 3, transcription factor 34856 0.23785 1.35 down Mm.139695 Epn2 102333_at AF057286 epsin 24857 0.23792 2.13 up Mm.34931 C77027 97137_at C76924 expressed sequence C770274858 0.23799 1.49 up Mm.116254 Msh3 160488_at L10319 mutS homolog 3 (E. coli)4859 0.23804 1.57 up Mm.30502 2210039B01Rik 100293_at AA268823 RIKEN cDNA 2210039B01 gene4860 0.23807 1.54 down 95093_at AI035334Page 54 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description4861 0.23816 1.41 up Mm.1716 Tncs 162325_f_at AV083137 troponin C, fast skeletal4862 0.23833 1.41 down Mm.257 Rras 94394_at M21019 Harvey rat sarcoma oncogene, subgroup R4863 0.23835 1.64 up Mm.89204 Hsf4 100384_at AB029349 heat shock transcription factor 44864 0.23851 1.69 up Mm.195092 Zfp63 95801_s_at L36316 zinc finger protein 634865 0.23856 1.43 down Mm.181610 6330577E15Rik 95446_at AW120502 RIKEN cDNA 6330577E15 gene4866 0.23860 1.62 up Mm.38441 Galnt3 99011_at U70538 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltra4867 0.23868 1.41 up Mm.4151 EL2 100755_at U04962 elastase4868 0.23878 1.45 up Mm.37755 Mm.37755 97691_at W91754 ESTs, Highly similar to RL2A MOUSE 60S RIBOSOMAL PROTEIN L27A [M4869 0.23886 1.96 up Mm.24934 C77070 95957_at C77070 expressed sequence C770704870 0.23890 1.26 up Mm.76659 Gnefr-pending 93633_at AJ243952 guanine nucleotide exchange factor (RCC1 related)4871 0.23894 1.48 down Mm.22660 Rab18 94319_at L04966 RAB18, member RAS oncogene family4872 0.23903 1.35 down Mm.587 Ptpra 100908_at M36033 protein tyrosine phosphatase, receptor type, A4873 0.23903 1.98 down Mm.3006 Il9 96574_at M30136 interleukin 94874 0.23903 1.52 up Mm.6212 Slc16a8 101623_at AF019111 solute carrier family 16 (monocarboxylic acid transporters), member 84875 0.23908 2.61 up Mm.4742 Pa2g4 162127_r_at AV306721 proliferation-associated 2G4, 38kD4876 0.23913 2.31 up Mm.204806 Mm.204806 96599_at AI845874 ESTs4877 0.23920 1.37 down Mm.19944 5730494G16Rik 103220_at AI851350 RIKEN cDNA 5730494G16 gene4878 0.23923 1.82 up Mm.88829 Casp9 100368_at AB019601 caspase 94879 0.23927 1.24 down Mm.200837 C81323 95069_at AA940430 expressed sequence C813234880 0.23945 1.63 up Mm.4646 Krt1-13 100109_s_at X03492 keratin complex 1, acidic, gene 134881 0.23949 1.24 up Mm.193688 2700059D21Rik 93767_i_at AW124052 RIKEN cDNA 2700059D21 gene4882 0.23952 2.19 up Mm.10692 Sprr2f 94120_s_at AJ005564 small proline-rich protein 2F4883 0.23958 1.41 down Mm.54120 Mm.54120 100889_at AI838576 ESTs, Weakly similar to T17286 hypothetical protein DKFZp434H0350.1 [H.s4884 0.23962 2.24 up Mm.34945 C78441 97144_at C78441 expressed sequence C784414885 0.23963 2.00 up Mm.142724 Og9x 93668_at U65068 OG9 homeobox gene4886 0.23969 1.49 up Mm.79067 1700014P03Rik 100318_at AI892206 RIKEN cDNA 1700014P03 gene4887 0.23970 2.84 up Mm.24531 AA414993 95177_at AA414993 expressed sequence AA4149934888 0.23974 2.04 up Mm.29960 AI326906 161241_at AV272626 expressed sequence AI3269064889 0.23989 1.63 up Mm.141365 Akr1e1 103068_at U68535 aldo-keto reductase family 1, member E14890 0.23992 1.59 up Mm.22086 Rnf14 93958_at AA086863 ring finger protein 144891 0.24000 1.22 down Mm.29490 D10Ertd73e 95161_at AW120628 DNA segment, Chr 10, ERATO Doi 73, expressed4892 0.24018 2.25 up Mm.89310 Sgcb 93898_at AB024921 sarcoglycan, beta (43kD dystrophin-associated glycoprotein)4893 0.24019 2.50 up Mm.7978 Efna5 99887_at U90664 ephrin A54894 0.24025 1.61 up Mm.946 D17Ertd315e 101934_at AI851119 DNA segment, Chr 17, ERATO Doi 315, expressed4895 0.24027 1.67 up Mm.27402 2010001P08Rik 104185_at AA616809 RIKEN cDNA 2010001P08 gene4896 0.24036 1.82 up Mm.20315 Fignl1 160648_at AI047076 fidgetin-like 14897 0.24037 1.25 down Mm.26392 Mm.26392 94426_at AI851052 Mus musculus, Similar to hypothetical protein FLJ20274, clone MGC:7161 IM4898 0.24054 1.32 down Mm.25549 1700016A15Rik 97380_at AI197431 RIKEN cDNA 1700016A15 gene4899 0.24068 1.15 down Mm.42826 Mrp64 99594_at AI844598 mitochondrial ribosomal protein 644900 0.24068 1.35 down Mm.18157 Axot 160103_at AW212859 axotrophin4901 0.24077 1.16 down Mm.806 Cd81 101495_at X59047 CD 81 antigen4902 0.24084 1.20 up Mm.196 Nedd8 93519_s_at AI847056 neural precursor cell expressed, developmentally down-regulated gene 84903 0.24090 1.68 up Mm.56685 Iqgap1 93850_at AI642553 IQ motif containing GTPase activating protein 14904 0.24104 2.17 up Mm.40672 Kcna3 92393_at M30441 potassium voltage-gated channel, shaker-related subfamily, member 34905 0.24111 1.23 down Mm.29608 2610024N24Rik 160348_at AW120787 RIKEN cDNA 2610024N24 gene4906 0.24118 2.43 up Mm.64249 Mm.64249 161483_r_at AV075508 EST4907 0.24118 1.47 up Mm.186 1300011C24Rik 162014_i_at AV248951 RIKEN cDNA 1300011C24 gene4908 0.24140 1.70 up Mm.22514 0610008F14Rik 94279_at AW125279 RIKEN cDNA 0610008F14 gene4909 0.24141 1.71 up Mm.5114 Dvl2 161408_r_at AV312528 dishevelled 2, dsh homolog (Drosophila)4910 0.24142 1.38 up Mm.197839 C80913 103682_at AA122571 expressed sequence C809134911 0.24146 1.59 up Mm.21693 2600016B03Rik 93980_at AW124520 RIKEN cDNA 2600016B03 gene4912 0.24156 1.69 up Mm.4453 Upk2 98370_at U14421 uroplakin 24913 0.24174 1.76 up Mm.28995 2010009J12Rik 103310_at AA220427 RIKEN cDNA 2010009J12 gene4914 0.24179 1.25 down Mm.5262 Chk 100516_at AB030621 choline kinase4915 0.24188 3.35 up Mm.4921 Gria2 162076_r_at AV327031 glutamate receptor, ionotropic, AMPA2 (alpha 2)4916 0.24190 1.35 down Mm.23942 Abcc3 103689_at AA833514 ATP-binding cassette, sub-family C (CFTR/MRP), member 34917 0.24206 1.67 up Mm.6255 Pitx3 99843_at AF005772 paired-like homeodomain transcription factor 34918 0.24219 1.37 up Mm.1260 Nme1 92794_f_at M35970 expressed in non-metastatic cells 1, protein (NM23A) (nucleoside diphospha4919 0.24223 1.91 up Mm.850 Srp14 162477_r_at AV096879 signal recognition particle 14 kDa (homologous Alu RNA binding protein)4920 0.24237 1.45 down Mm.15125 Sdfr1 93043_at D50463 stromal cell derived factor receptor 14921 0.24251 1.35 down Mm.417 Zfp148 99502_at U80078 zinc finger protein 1484922 0.24254 1.49 up Mm.6839 Cdk4 160538_at L01640 cyclin-dependent kinase 44923 0.24254 1.69 up Mm.154431 AF013969 92211_at AF013969 expressed sequence AF0139694924 0.24260 1.33 up Mm.141066 Synj2bp 101548_at AI846345 synaptojanin 2 binding protein4925 0.24261 1.87 up Mm.3009 Sth2 104484_at L27121 sulfotransferase, hydroxysteroid preferring 24926 0.24267 1.38 up Mm.171514 AI414849 103527_at AW124360 expressed sequence AI4148494927 0.24270 1.24 up Mm.21064 2900001O04Rik 103852_at AI848207 RIKEN cDNA 2900001O04 gene4928 0.24273 1.44 down Mm.196373 Hoxa11s 93873_s_at U20366 homeo box A11, opposite strand transcript4929 0.24283 1.38 down Mm.200975 Serf2 162055_f_at AV382097 small EDRK-rich factor 24930 0.24297 1.48 down 160379_at L009194931 0.24304 1.61 up Mm.20377 Mm.20377 103641_at AW124853 ESTs, Moderately similar to SEC_HUMAN SEC PROTEI [H.sapiens]4932 0.24307 1.19 down Mm.27232 5830462I21Rik 94973_at AA840126 RIKEN cDNA 5830462I21 gene4933 0.24315 1.44 up Mm.20132 Mm.20132 100839_at AI327166 EST, Moderately similar to JC5878 plasma hyaluronan-binding protein precu4934 0.24316 1.31 down Mm.41943 Pik3ca 92452_at U03279 phosphatidylinositol 3-kinase, catalytic, alpha polypeptide4935 0.24325 1.76 up Mm.21212 Cpn1 103882_at AI182588 carboxypeptidase N, polypeptide 1, 50kD4936 0.24328 1.66 up Mm.190 Scyc1 103199_at U15607 small inducible cytokine subfamily C, member 1 (lymphotactin)4937 0.24330 1.46 down Mm.2654 Wdr1 96075_at AW060876 WD repeat domain 14938 0.24334 2.27 up Mm.4777 Orm1 100436_at M27008 orosomucoid 14939 0.24351 3.43 up Mm.29975 Gatm 96336_at AI844626 glycine amidinotransferase (L-arginine:glycine amidinotransferase)4940 0.24354 1.20 down Mm.104955 Spint1 97206_at AW230369 serine protease inhibitor, Kunitz type 14941 0.24374 2.14 up Mm.4675 Pla2g2a 92735_at X74266 phospholipase A2, group IIA (platelets, synovial fluid)4942 0.24375 1.55 up Mm.4645 Six1 92722_f_at X80339 sine oculis-related homeobox 1 homolog (Drosophila)4943 0.24384 1.66 up Mm.3783 Mm.3783 160446_at U46068 Mus musculus von Ebner minor salivary gland protein mRNA, complete cds4944 0.24391 1.34 up Mm.206737 Adir 96533_at AI508931 ATP-dependant interferon responsive4945 0.24399 2.21 up Mm.103783 Il12a 100773_at M86672 interleukin 12a4946 0.24405 2.13 up Mm.28546 Mm.28546 104192_at AW121876 Mus musculus, Similar to hypothetical protein FLJ20505, clone MGC:7150 IM4947 0.24422 1.66 up Mm.124 Tmpo 92782_at U39074 thymopoietin4948 0.24423 1.35 up Mm.1802 Prrx2 103327_at X52875 paired related homeobox 24949 0.24426 1.79 up Mm.2779 Gpld1 161399_r_at AV274713 glycosylphosphatidylinositol specific phospholipase D14950 0.24428 1.52 up Mm.1252 Mcpt5 102408_g_at M68898 mast cell protease 5Page 55 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description4951 0.24439 1.37 down Mm.137177 AW050020 97355_at AW050020 expressed sequence AW0500204952 0.24455 2.70 up Mm.140610 Gna12 97227_at M63659 guanine nucleotide binding protein, alpha 124953 0.24461 1.94 up Mm.31387 Nr5a1 161418_r_at AV320880 nuclear receptor subfamily 5, group A, member 14954 0.24472 22.93 up Mm.321 Spp1 97519_at X13986 secreted phosphoprotein 14955 0.24476 1.91 up Mm.88367 Gfra1 93872_at AF014117 glial cell line derived neurotrophic factor family receptor alpha 14956 0.24486 1.72 up Mm.253 AA536646 95514_at AI846302 expressed sequence AA5366464957 0.24493 1.43 down Mm.216207 Mm.216207 160694_at U69599 Mus musculus interferon gamma receptor 2 (Ifngr2), mRNA4958 0.24498 1.47 up Mm.28003 Cbx5 104259_at X99641 chromobox homolog 5 (Drosophila HP1a)4959 0.24499 1.89 up Mm.24912 Mm.24912 95856_at C76489 ESTs4960 0.24506 1.59 up Mm.5567 Pdlim1 100554_at AF053367 PDZ and LIM domain 1 (elfin)4961 0.24515 1.47 up Mm.41935 1200003F12Rik 99194_at AW124271 RIKEN cDNA 1200003F12 gene4962 0.24528 2.49 up Mm.20850 V1ra2 95342_at Y12724 vomeronasal 1 receptor, A24963 0.24528 2.01 up Mm.5290 Pop3-pending 103484_at AA619442 popeye 34964 0.24529 1.48 up Mm.6818 Itgb1bp1 100989_at AJ001373 integrin beta 1 binding protein 14965 0.24531 1.33 up Mm.1947 AW060987 103574_at AI841606 expressed sequence AW0609874966 0.24532 3.79 up Mm.30349 Foxd4 101648_at X86368 forkhead box D44967 0.24554 1.88 up Mm.42175 D15Ertd50e 102086_r_at C77593 DNA segment, Chr 15, ERATO Doi 50, expressed4968 0.24559 1.22 down Mm.20522 Lancl1 103656_at Y16518 LanC (bacterial lantibiotic synthetase component C)-like4969 0.24561 1.56 down Mm.29846 R74996 161998_f_at AV329719 expressed sequence R749964970 0.24565 1.65 down Mm.8149 Mak 93675_at X66983 male germ cell-associated kinase4971 0.24568 1.26 down Mm.202224 AI159700 97118_at AI159700 expressed sequence AI1597004972 0.24570 1.58 up Mm.60219 C79328 161887_r_at AV370769 expressed sequence C793284973 0.24572 1.41 up Mm.7331 Pbx3 93616_g_at AF020200 pre B-cell leukemia transcription factor 34974 0.24576 1.35 up Mm.7409 Mcpt6 93622_at M57626 mast cell protease 64975 0.24581 1.68 down Mm.18709 Sgca 160631_s_at AV206713 sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)4976 0.24583 1.87 down Mm.10509 Mm.10509 94111_r_at D10627 Mus musculus mRNA for zinc finger protein, partial cds4977 0.24590 1.51 up Mm.27613 AI507495 95528_at AA791234 expressed sequence AI5074954978 0.24614 1.87 up Mm.26262 Mos 161867_f_at AV357553 Moloney sarcoma oncogene4979 0.24617 2.30 up Mm.6716 H2-Ab1 100998_at M21932 histocompatibility 2, class II antigen A, beta 14980 0.24624 1.72 up Mm.2180 Hsp84-1 161761_r_at AV302219 heat shock protein, 84 kDa 14981 0.24639 1.65 up Mm.1280 Spt1 94152_at M33974 salivary protein 14982 0.24641 1.47 up Mm.4904 Pou2f3 92933_at Z18537 POU domain, class 2, transcription factor 34983 0.24644 1.44 down Mm.2011 Gstm1 102094_f_at AI841270 glutathione S-transferase, mu 14984 0.24644 2.27 up Mm.154144 Arg1 93097_at U51805 arginase 1, liver4985 0.24645 2.11 up Mm.143765 Pth 102078_at AF066075 parathyroid hormone4986 0.24662 1.63 up Mm.42150 Rasgrp1 98307_at AF106070 RAS guanyl releasing protein 14987 0.24667 1.57 up Mm.219541 Mm.219541 97178_at AI314034 Mus musculus, Similar to RIKEN cDNA 9030624G23 gene, clone MGC:36374988 0.24672 1.39 down Mm.20928 Mtap7 93729_at Y15197 microtubule-associated protein 74989 0.24676 1.56 up Mm.12895 Scya22 102310_at AF052505 small inducible cytokine subfamily A, member 224990 0.24683 1.50 up Mm.1504 Zfp46 102882_at M98502 zinc finger protein 464991 0.24702 2.79 up Mm.2857 Admr 162449_f_at AV355809 adrenomedullin receptor4992 0.24711 1.85 up Mm.116761 Car5a 98137_at X51971 carbonic anhydrase 5a, mitochondrial4993 0.24714 1.26 up Mm.24972 Mvp 162447_f_at AV353436 major vault protein4994 0.24722 1.81 down Mm.86744 Rab23 93718_at Z22821 RAB23, member RAS oncogene family4995 0.24723 1.36 up Mm.28232 Mm.28232 96148_at AI844238 ESTs, Moderately similar to SUS1_HUMAN SUMO-1-specific protease 1 (Se4996 0.24731 1.92 up Mm.180363 2610039C10Rik 160784_r_at AI846439 RIKEN cDNA 2610039C10 gene4997 0.24737 1.45 down Mm.142479 2400003C14Rik 96669_at AW122973 RIKEN cDNA 2400003C14 gene4998 0.24742 1.28 up Mm.44552 Txnrd1 161284_r_at AV299386 thioredoxin reductase 14999 0.24747 1.56 up Mm.14118 V2r9 100677_f_at AF011419 vomeronasal 2, receptor, 95000 0.24749 1.48 down Mm.154358 6430511D02Rik 102009_at AI835274 RIKEN cDNA 6430511D02 gene5001 0.24751 1.52 down Mm.196498 1810010N17Rik 160486_at AI848822 RIKEN cDNA 1810010N17 gene5002 0.24765 2.08 up Mm.874 Il10 100319_at M37897 interleukin 105003 0.24766 1.53 down Mm.218489 Mm.218489 97108_at AW049927 Mus musculus, clone MGC:30621 IMAGE:3673217, mRNA, complete cds5004 0.24770 1.71 up Mm.206691 Hbb-b2 103534_at V00722 hemoglobin, beta adult minor chain5005 0.24771 1.28 down Mm.219645 Mm.219645 96726_at AW049619 Mus musculus, clone MGC:37111 IMAGE:4952234, mRNA, complete cds5006 0.24775 1.21 down Mm.141066 Synj2bp 96734_at AA674143 synaptojanin 2 binding protein5007 0.24784 1.83 up Mm.4027 Hoxa4 97745_at M27432 homeo box A45008 0.24786 1.50 down Mm.34384 Bid 98433_at U75506 BH3 interacting domain death agonist5009 0.24791 1.81 up Mm.1241 Kcna5 161775_f_at AV345198 potassium voltage-gated channel, shaker-related subfamily, member 55010 0.24800 1.38 down Mm.21740 Hnrph1 93990_at Y14196 heterogeneous nuclear ribonucleoprotein H15011 0.24801 1.48 down Mm.5154 F8a 160902_at M83118 factor 8-associated gene A5012 0.24814 1.73 up Mm.70309 3830418C19Rik 100887_at AI838562 RIKEN cDNA 3830418C19 gene5013 0.24835 2.73 up Mm.28678 Mark3 161744_f_at AV317825 MAP/microtubule affinity-regulating kinase 35014 0.24843 1.49 down Mm.21919 C80248 104110_at AW060515 expressed sequence C802485015 0.24847 1.53 up Mm.5879 Tyms 93237_s_at AU044050 thymidylate synthase5016 0.24851 1.27 down Mm.10343 Mm.10343 160578_at AW122388 ESTs5017 0.24854 2.06 up Mm.10701 Siat8d 102318_at X86000 sialyltransferase 8 (alpha-2, 8-sialytransferase) D5018 0.24856 1.76 up Mm.35851 Sap18 98534_at Z97062 Sin3-associated polypeptide 185019 0.24858 1.70 up Mm.3794 Stk18 98996_at L29480 serine/threonine kinase 185020 0.24870 1.76 up Mm.1205 Rpr1 162267_r_at AV361373 rod photoreceptor 15021 0.24880 1.47 down Mm.15351 1110054N06Rik 93056_g_at AW049376 RIKEN cDNA 1110054N06 gene5022 0.24890 1.95 up Mm.10704 Snx12 102319_at AF062484 sorting nexin 125023 0.24912 2.08 up Mm.142718 Kcna4 101786_at U03723 potassium voltage-gated channel, shaker-related subfamily, member 45024 0.24914 1.91 down Mm.40277 Ptprz 92380_r_at AJ133130 protein tyrosine phosphatase, receptor type, Z5025 0.24915 1.86 up Mm.4399 Mm.4399 101126_r_at AA545222 EST5026 0.24921 1.28 up Mm.28975 2610312E17Rik 94510_at AI853476 RIKEN cDNA 2610312E17 gene5027 0.24926 1.34 down Mm.34576 Ierepo1-pending 98083_at AW049031 immediate early response, erythropoietin 15028 0.24936 1.92 up Mm.10739 Advil-pending 102249_at AF041448 advillin5029 0.24937 2.10 up Mm.2305 Tcfeb 104526_at U36393 transcription factor EB5030 0.24944 2.34 up Mm.57203 Hcfc1 100901_at U80821 host cell factor C15031 0.24950 1.41 down Mm.2011 Gstm1 93543_f_at J03952 glutathione S-transferase, mu 15032 0.24950 1.52 up Mm.27828 4930402F02Rik 160755_at AA007891 RIKEN cDNA 4930402F02 gene5033 0.24969 1.33 up Mm.27307 Gng3 94986_at AF069953 guanine nucleotide binding protein (G protein), gamma 3 subunit5034 0.24975 2.14 up Mm.200509 Hspc121-pending 93212_at Z97207 butyrate-induced transcript 15035 0.24979 1.36 down Mm.5390 C77355 93179_at AW049961 expressed sequence C773555036 0.24992 1.86 up Mm.25613 Ier3 161281_f_at AV292869 immediate early response 35037 0.24995 2.12 up Mm.4820 Nf1 98809_s_at D30730 neurofibromatosis 15038 0.25006 1.77 up Mm.153729 2210010C04Rik 92712_at AE000663 RIKEN cDNA 2210010C04 gene5039 0.25011 2.60 up Mm.7281 Col5a1 101080_at AB009993 procollagen, type V, alpha 15040 0.25015 2.29 up Mm.37491 C77405 101692_r_at C77405 expressed sequence C77405Page 56 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description5041 0.25027 1.82 up Mm.214981 Hist1 101784_f_at X16496 histone gene complex 15042 0.25040 1.45 down Mm.919 Zfx 101919_at M32309 zinc finger protein X-linked5043 0.25053 1.58 up Mm.5030 Gkap42-pending 162359_r_at AV220336 42 kD cGMP-dependent protein kinase anchoring protein5044 0.25069 1.67 down Mm.18062 AU044632 103332_at AI197507 expressed sequence AU0446325045 0.25069 2.28 up Mm.13264 Rgs11 161309_r_at AV076835 regulator of G-protein signaling 115046 0.25074 1.37 down Mm.21972 2810037C14Rik 104118_at AW123781 RIKEN cDNA 2810037C14 gene5047 0.25083 1.46 up Mm.6958 Capn2 101040_at D38117 calpain 25048 0.25085 1.72 up Mm.2397 Syp 160181_at X95818 synaptophysin5049 0.25087 1.58 up Mm.16711 Mcmd2 93112_at D86725 mini chromosome maintenance deficient 2 (S. cerevisiae)5050 0.25087 8.16 up Mm.2692 Cd53 94939_at X97227 CD53 antigen5051 0.25088 1.59 up Mm.57243 Hrh2 99815_at D50096 histamine receptor H 25052 0.25100 1.70 up Mm.46801 Mm.46801 101326_at U23025 M.musculus mRNA (2F7) for IgA V-D-J-heavy chain5053 0.25104 1.24 down Mm.22315 AA409502 104294_at AI850948 expressed sequence AA4095025054 0.25117 1.91 up Mm.28681 Mm.28681 104401_at AI846624 ESTs, Weakly similar to ZF29 MOUSE ZINC FINGER PROTEIN 29 [M.musc5055 0.25130 2.22 up Mm.3407 Adcyap1 92200_at AB010149 adenylate cyclase activating polypeptide 15056 0.25135 1.35 down Mm.25018 Mm.25018 95488_at AW045756 Mus musculus, clone IMAGE:3597827, mRNA, partial cds5057 0.25144 1.82 up Mm.20944 Sphk1 103839_at AF068748 sphingosine kinase 15058 0.25153 1.71 up Mm.5168 Adam3 161196_r_at AV254135 a disintegrin and metalloprotease domain 3 (cyri<strong>test</strong>in)5059 0.25169 1.96 up Mm.5224 Mm.5224 101205_at T25652 EST5060 0.25169 1.35 up Mm.42233 Aanat 92512_g_at AF004108 arylalkylamine N-acetyltransferase5061 0.25175 1.51 up Mm.57177 Fgf7 99435_at Z22703 fibroblast growth factor 75062 0.25180 1.63 up Mm.16857 Cdc25c 102934_s_at L16926 cell division cycle 25 homolog C (S. cerevisiae)5063 0.25195 13.63 up Mm.177539 Lzp-s 101753_s_at X51547 P lysozyme structural5064 0.25203 1.34 up Mm.27521 AA409802 104199_at AI646237 expressed sequence AA4098025065 0.25210 1.59 up Mm.23566 D4Ertd13e 94856_r_at AI842362 DNA segment, Chr 4, ERATO Doi 13, expressed5066 0.25216 1.37 up Mm.1960 Mm.1960 161723_at AV264147 ESTs, Weakly similar to beta-transducin [Caenorhabditis elegans] [C.elegan5067 0.25219 1.18 down Mm.182471 2610524G07Rik 99512_at AI852647 RIKEN cDNA 2610524G07 gene5068 0.25226 1.29 up Mm.3094 1200011O22Rik 97488_at AI595893 RIKEN cDNA 1200011O22 gene5069 0.25234 2.01 up Mm.5112 Npy1r 93128_at D63819 neuropeptide Y receptor Y15070 0.25235 1.80 up Mm.50 C87117 160897_at AW060889 expressed sequence C871175071 0.25243 1.75 up Mm.29127 Cipp 104425_at AF060539 channel-interacting PDZ domain protein5072 0.25244 2.84 up Mm.6354 Pigq 101646_at AF030178 phosphatidylinositol glycan, class Q5073 0.25248 2.07 up Mm.1927 Srpx 103568_at AB028049 sushi-repeat-containing protein5074 0.25279 10.59 up Mm.14302 Cmkbr5 161968_f_at AV370035 chemokine (C-C) receptor 55075 0.25279 1.49 down Mm.196592 2310075M17Rik 94871_r_at AW124226 RIKEN cDNA 2310075M17 gene5076 0.25301 1.31 up Mm.3486 Rpl3 100734_at Y00225 ribosomal protein L35077 0.25314 1.24 down Mm.7723 Pabpn1 101476_at U93050 poly(A) binding protein, nuclear 15078 0.25314 1.74 up Mm.1252 Mcpt5 102406_at M73760 mast cell protease 55079 0.25318 1.55 down Mm.5008 Vpreb1 161297_f_at AV015107 pre-B lymphocyte gene 15080 0.25323 1.47 up Mm.228 Homer2-pending 160695_i_at AF093259 homer, neuronal immediate early gene, 25081 0.25328 1.47 up Mm.1228 Cryaa 102393_at J00376 crystallin, alpha A5082 0.25338 1.17 down Mm.28897 2010317E03Rik 160314_at AI839803 RIKEN cDNA 2010317E03 gene5083 0.25358 1.51 up Mm.3470 Rxra 92234_at X66223 retinoid X receptor alpha5084 0.25369 1.68 up Mm.891 Kifc2 93891_at U92949 kinesin family member C25085 0.25372 2.00 up Mm.1001 Pp11r 102203_at M95545 placental protein 11 related5086 0.25379 1.53 down Mm.1951 Rnps1 93518_at X70067 ribonucleic acid binding protein S15087 0.25394 2.43 up Mm.26132 D9Ertd720e 96520_at AA399835 DNA segment, Chr 9, ERATO Doi 720, expressed5088 0.25395 1.42 down Mm.6118 AI790646 100582_at AW123761 expressed sequence AI7906465089 0.25396 2.71 up Mm.5356 AU016588 161141_r_at AV159605 expressed sequence AU0165885090 0.25403 1.39 down Mm.734 Nras 160925_at X13664 neuroblastoma ras oncogene5091 0.25420 1.29 up Mm.203962 Bat3 93922_g_at AI573601 HLA-B-associated transcript 35092 0.25423 1.65 up Mm.4415 Kif2 99962_at D12644 kinesin heavy chain member 25093 0.25468 1.59 down Mm.168 Ifrd1 160092_at V00756 interferon-related developmental regulator 15094 0.25477 1.37 up Mm.24875 Mrps18a 94326_r_at AW060921 mitochondrial ribosomal protein S18A5095 0.25478 1.82 down Mm.1603 Rbbp7 99343_at AA796133 retinoblastoma binding protein 75096 0.25485 1.86 up Mm.42032 Crsp2 97796_at AB019029 cofactor required for Sp1 transcriptional activation subunit 2 (150 kDa)5097 0.25488 1.41 down Mm.86323 AI462446 93702_at AW120888 expressed sequence AI4624465098 0.25489 1.34 up Mm.27216 D19Ertd410e 94967_at AI851365 DNA segment, Chr 19, ERATO Doi 410, expressed5099 0.25493 1.31 down Mm.29089 Pcbp1 94552_at AI839477 poly(rC) binding protein 15100 0.25494 1.87 up Mm.57236 Neurog3 99814_at Y09167 neurogenin 35101 0.25498 2.32 up Mm.4709 Wnt10b 92750_s_at AF029307 wingless related MMTV integration site 10b5102 0.25507 2.00 up Mm.45982 D0Kist4 98763_at U80891 DNA segment, KIST 45103 0.25512 1.55 up Mm.42088 Gbif-pending 92468_at AF028722 globin inducing factor, fetal5104 0.25513 2.20 up Mm.21905 Rab2 162141_r_at AV349603 RAB2, member RAS oncogene family5105 0.25527 2.08 up Mm.66 Rps4x 162244_r_at AV171368 ribosomal protein S4, X-linked5106 0.25530 1.99 up Mm.3556 P2ry1 97168_at U22829 purinergic receptor P2Y, G-protein coupled 15107 0.25531 1.55 up Mm.14663 Atp5l 99678_f_at AU018994 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g5108 0.25549 1.51 up Mm.219134 Zfp67 160331_at Z36549 zinc finger protein 675109 0.25562 1.32 down Mm.27608 Mm.27608 96709_at AI839839 Mus musculus, Similar to chromosome 9 open reading frame 16, clone MGC5110 0.25570 1.75 up Mm.625 Sprr1a 160909_at AF057156 small proline-rich protein 1A5111 0.25575 1.52 up Mm.18263 Ggtla1 102968_at AF077765 gamma-glutamyltransferase-like activity 15112 0.25580 1.46 up Mm.27494 Heph 104194_at AF082567 hephaestin5113 0.25582 1.65 up Mm.2436 Bhlhb2 104701_at Y07836 basic helix-loop-helix domain containing, class B25114 0.25586 1.94 down Mm.1237 Pmp22 161442_at AV351615 peripheral myelin protein, 22 kDa5115 0.25597 1.34 down Mm.197941 2010006G21Rik 97839_at AI841960 RIKEN cDNA 2010006G21 gene5116 0.25603 1.21 down Mm.182114 2310008D22Rik 97505_at AI845999 RIKEN cDNA 2310008D22 gene5117 0.25616 2.72 up Mm.2078 Gfi1 103259_at U58972 growth factor independent 15118 0.25625 2.24 up Mm.30217 Cibkip-pending 96958_at AA647796 calcium and integrin binding, protein kinase interacting protein5119 0.25627 1.71 down Mm.123225 C80816 104256_at AI120844 expressed sequence C808165120 0.25630 1.46 up Mm.23742 Nes 161829_at AV022960 nestin5121 0.25632 1.64 up Mm.20854 Pdi1 95343_at AB013848 peptidyl arginine deiminase, type I5122 0.25649 1.45 down Mm.19135 AI648770 103564_at AI020259 expressed sequence AI6487705123 0.25653 1.53 down Mm.27341 Mm.27341 160739_at AI835081 ESTs, Highly similar to AF227741 1 protein kinase WNK1 [R.norvegicus]5124 0.25656 1.82 up Mm.140509 Alas2 92768_s_at M15268 aminolevulinic acid synthase 2, erythroid5125 0.25664 1.33 up Mm.27703 Mm.27703 160750_at AI851674 Mus musculus, phosphoribosyl pyrophosphate synthetase-associated protein5126 0.25690 1.60 down Mm.5115 Gip 98858_at U34295 gastric inhibitory polypeptide5127 0.25690 6.95 up Mm.14465 Gzmc 102733_at M22527 granzyme C5128 0.25698 1.46 down Mm.144420 0610038P07Rik 104249_g_at AW227650 RIKEN cDNA 0610038P07 gene5129 0.25698 1.77 up Mm.10740 Wnt2b 94126_at AF070988 wingless related MMTV integration site 2b5130 0.25709 1.63 up Mm.38801 1200015A22Rik 98633_at AI854863 RIKEN cDNA 1200015A22 genePage 57 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description5131 0.25714 1.88 up Mm.38779 Mm.38779 101695_at AI747163 EST, Moderately similar to I75615 mammary tumor integration site 6 oncoge5132 0.25720 1.37 down Mm.28200 D11Ertd730e 160772_i_at AW214428 DNA segment, Chr 11, ERATO Doi 730, expressed5133 0.25727 1.51 down Mm.12454 AI452351 92786_at AI626942 expressed sequence AI4523515134 0.25731 1.36 up Mm.66 Rps4x 100780_at M73436 ribosomal protein S4, X-linked5135 0.25758 1.74 up Mm.24771 Il1rap 103769_at X85999 interleukin 1 receptor accessory protein5136 0.25776 2.01 down Mm.21652 3930401K13Rik 93969_at AI854082 RIKEN cDNA 3930401K13 gene5137 0.25778 1.84 up Mm.71797 Mm.71797 161705_r_at AV239269 EST5138 0.25779 1.86 up Mm.57112 Erbb3 101776_at AF059175 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)5139 0.25781 1.30 up Mm.36569 Usp8 98972_at AI574262 ubiquitin specific protease 85140 0.25792 1.32 up Mm.2969 Akap 97368_at U95145 A kinase anchor protein5141 0.25803 2.10 down Mm.3511 Matn2 161776_at AV345275 matrilin 25142 0.25806 1.62 up Mm.2731 Pemt 94987_at U25051 phosphatidylethanolamine N-methyltransferase5143 0.25821 1.48 down 98013_at AA6664645144 0.25824 1.37 down Mm.219661 Mm.219661 95401_at AW050156 Mus musculus, clone IMAGE:4913219, mRNA, partial cds5145 0.25850 1.45 down Mm.200346 AA407068 104210_at AI839082 expressed sequence AA4070685146 0.25866 15.65 up Mm.10299 Col5a2 92567_at L02918 procollagen, type V, alpha 25147 0.25873 1.94 up Mm.29615 2610001J05Rik 162419_r_at AV323674 RIKEN cDNA 2610001J05 gene5148 0.25876 1.38 down Mm.29500 Mm.29500 95647_f_at AI465845 Mus musculus, hypothetical protein FLJ10788, clone MGC:6884 IMAGE:2655149 0.25878 3.05 down Mm.43952 D13Ertd37e 102138_at C77383 DNA segment, Chr 13, ERATO Doi 37, expressed5150 0.25890 2.06 up Mm.4010 Vil 99074_at M98454 villin5151 0.25895 1.28 up Mm.4011 1110046L09Rik 160858_at AW045976 RIKEN cDNA 1110046L09 gene5152 0.25895 1.69 down Mm.183117 D8Wsu151e 96023_at AI852472 DNA segment, Chr 8, Wayne State University 151, expressed5153 0.25897 2.61 down Mm.22706 Bpgm 94815_at X13586 2,3-bisphosphoglycerate mutase5154 0.25915 1.36 up Mm.42767 Rps17 99590_at D25213 ribosomal protein S175155 0.25920 1.40 up Mm.3759 Mnt 92300_at Y07609 max binding protein5156 0.25923 1.60 up Mm.24594 Slc25a19 97373_at AI852682 solute carrier family 25 (mitochondrial deoxynucleotide carrier), member 195157 0.25926 1.90 up Mm.4081 Runx1 92399_at D26532 runt related transcription factor 15158 0.25927 2.14 up Mm.4873 Dlx5 92930_at U67840 distal-less homeobox 55159 0.25927 1.58 up Mm.196638 Rab6kifl 161856_f_at AV059766 Rab6, kinesin-like5160 0.25928 1.61 up Mm.154810 Mm.154810 97169_f_at AF067058 Mus musculus clone L10 variable group of 2-cell-stage gene family mRNA, c5161 0.25931 1.35 down Mm.27560 Uble1b 96701_at U35833 ubiquitin-like 1 (sentrin) activating enzyme E1B5162 0.25942 1.28 up Mm.30078 AA589396 96882_at AI842936 expressed sequence AA5893965163 0.25967 2.63 up Mm.57020 Slc18a3 101354_at AF019045 solute carrier family 18 (vesicular monoamine), member 35164 0.25971 1.99 up Mm.1064 Smcy 100272_at Z29652 selected mouse cDNA on the Y5165 0.25978 1.24 up Mm.6821 Cct4 101011_at L25913 chaperonin subunit 4 (delta)5166 0.25981 1.35 up Mm.20904 Crtap 103817_at AJ006469 cartilage associated protein5167 0.25985 1.38 down Mm.7070 1110030M18Rik 101380_at AW048282 RIKEN cDNA 1110030M18 gene5168 0.25986 1.28 up Mm.2133 AV028425 161941_r_at AV336987 expressed sequence AV0284255169 0.26010 1.78 up Mm.2549 Hk2 161313_at AV085600 hexokinase 25170 0.26016 1.37 up Mm.2077 AA415275 103669_at AA793857 expressed sequence AA4152755171 0.26034 1.82 up Mm.29132 2310045A07Rik 95048_at AI118856 RIKEN cDNA 2310045A07 gene5172 0.26039 1.23 up Mm.28576 1110008B24Rik 98901_at AW047870 RIKEN cDNA 1110008B24 gene5173 0.26039 1.35 down Mm.2720 Mapk8ip 104170_at AF003115 mitogen activated protein kinase 8 interacting protein5174 0.26047 1.48 down Mm.28852 1810004F21Rik 94472_at AW123216 RIKEN cDNA 1810004F21 gene5175 0.26047 1.74 up Mm.852 Scel 161132_at AA727482 sciellin5176 0.26070 1.69 up Mm.5070 Acvr1b 101177_at Z31663 activin A receptor, type 1B5177 0.26071 1.18 up Mm.4011 1110046L09Rik 161147_f_at AV221100 RIKEN cDNA 1110046L09 gene5178 0.26074 1.14 down Mm.28375 Sec61a 160291_at AI838624 SEC61, alpha subunit (S. cerevisiae)5179 0.26075 2.09 up Mm.2965 Mm.2965 161871_f_at AV360150 Mus musculus, Similar to rhodopsin (opsin 2, rod pigment) (retinitis pigmento5180 0.26086 1.71 up Mm.24247 Mm.24247 161103_at AA250256 ESTs5181 0.26098 1.83 up Mm.21983 Bhmt 161404_at AV279130 betaine-homocysteine methyltransferase5182 0.26099 1.79 up Mm.28571 Psmd11 160304_r_at AA414947 proteasome (prosome, macropain) 26S subunit, non-ATPase, 115183 0.26131 1.49 down Mm.25017 Mm.25017 95978_at AA414964 ESTs, Weakly similar to YBF7_CAEEL PROBABLE CATION-TRANSPORTI5184 0.26144 1.26 up Mm.22986 Gltp-pending 161816_r_at AV375661 glycolipid transfer protein5185 0.26148 1.22 down Mm.177991 0610010I12Rik 97269_f_at AI848699 RIKEN cDNA 0610010I12 gene5186 0.26148 2.28 up Mm.456 Gif 92690_at L24191 gastric intrinsic factor5187 0.26171 1.41 up Mm.22248 Igfbp4 94222_at AI838737 insulin-like growth factor binding protein 45188 0.26187 2.03 up Mm.19081 AW260363 103556_at AI840158 expressed sequence AW2603635189 0.26189 1.56 up Mm.212056 Mm.212056 160216_f_at AI503011 ESTs5190 0.26196 1.46 up Mm.26091 Fosb 103990_at X14897 FBJ osteosarcoma oncogene B5191 0.26200 1.74 up Mm.18054 Mm.18054 103331_at AI854450 Mus musculus, clone MGC:28718 IMAGE:4458439, mRNA, complete cds5192 0.26215 1.21 down Mm.1985 1500011L16Rik 93533_at AI853651 RIKEN cDNA 1500011L16 gene5193 0.26228 1.77 up Mm.20156 2610042F04Rik 103605_g_at AW231026 RIKEN cDNA 2610042F04 gene5194 0.26231 2.14 up Mm.675 Oaz2 160467_at AB016275 ornithine decarboxylase antizyme 25195 0.26235 1.48 down Mm.23335 Yme1l1 97102_at AA276948 YME1-like 1 (S. cerevisiae)5196 0.26236 1.52 up Mm.25102 Mm.25102 96485_at C81148 EST5197 0.26244 2.10 up Mm.4583 Chrna1 100021_at M17640 cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)5198 0.26252 2.05 up Mm.310 Zfp103 161940_r_at AV336118 zinc finger protein 1035199 0.26258 1.15 down Mm.27344 AI046671 96658_at AI841906 expressed sequence AI0466715200 0.26274 2.00 down Mm.4792 Zfp354a 98803_at L77247 zinc finger protein 354A5201 0.26275 1.21 down Mm.27427 D14Ucla2 96678_at AW260761 DNA segment, Chr 14, University of California at Los Angeles 25202 0.26277 1.45 down Mm.5364 Mm.5364 99347_f_at AA111360 ESTs5203 0.26296 2.36 down Mm.20888 Elf5 103283_at AF049702 E74-like factor 55204 0.26301 1.86 up Mm.6499 AW121806 93428_at AW121806 expressed sequence AW1218065205 0.26312 1.53 up Mm.182914 2700038C09Rik 93838_at AI846994 RIKEN cDNA 2700038C09 gene5206 0.26323 1.43 up Mm.27284 2810422O20Rik 160999_r_at AI552570 RIKEN cDNA 2810422O20 gene5207 0.26327 1.95 down Mm.4475 Btk 161971_r_at AV227438 Bruton agammaglobulinemia tyrosine kinase5208 0.26338 1.54 down Mm.63881 Adarb1 161436_s_at AV345565 adenosine deaminase, RNA-specific, B15209 0.26354 1.38 up Mm.21119 Litaf-pending 93753_at AI852632 LPS-induced TNF-alpha factor5210 0.26357 1.47 down Mm.28904 D15Ertd781e 96737_at AI849705 DNA segment, Chr 15, ERATO Doi 781, expressed5211 0.26359 1.46 up Mm.982 Edg1 99372_at AF108020 endothelial differentiation sphingolipid G-protein-coupled receptor 15212 0.26365 1.51 up Mm.8026 Pax4 99908_at AB010557 paired box gene 45213 0.26368 1.43 down Mm.38344 Nnp1 98604_at U79774 novel nuclear protein 15214 0.26388 1.59 up Mm.5749 AI450241 101235_f_at C78782 expressed sequence AI4502415215 0.26388 2.07 down Mm.2284 Hexa 162488_at AV133930 hexosaminidase A5216 0.26391 2.08 up Mm.129 Gsc 94187_at M85271 goosecoid5217 0.26395 1.70 up Mm.1306 Gbx2 94200_at Z48800 gastrulation brain homeobox 25218 0.26400 1.40 down Mm.1225 Col17a1 160594_at L08407 procollagen, type XVII, alpha 15219 0.26406 1.31 down Mm.3360 Ywhaz 97544_at D83037 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,5220 0.26423 1.38 down Mm.21853 Pxmp2 104098_at L28835 peroxisomal membrane protein 2, 22 kDaPage 58 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description5221 0.26427 2.99 up Mm.5160 Ugt8 98872_at U48896 UDP-glucuronosyltransferase 85222 0.26432 1.90 up Mm.87787 Lta 102630_s_at M16819 lymphotoxin A5223 0.26434 1.29 up Mm.29483 1600025H15Rik 162284_r_at AV372398 RIKEN cDNA 1600025H15 gene5224 0.26436 1.82 up Mm.3524 Krtap6-2 92253_at D89902 keratin associated protein 6-25225 0.26437 1.34 down Mm.2672 Mgat1 161492_i_at AV089873 mannoside acetylglucosaminyltransferase 15226 0.26438 1.52 down Mm.3459 Dbp 160841_at AW047343 D site albumin promoter binding protein5227 0.26463 2.58 up Mm.153716 Meox2 99937_at Z16406 mesenchyme homeobox 25228 0.26471 1.66 up Mm.10294 Dapk3 92566_at AB007143 death-associated kinase 35229 0.26472 1.43 down Mm.24130 Cd52 104606_at M55561 CD52 antigen5230 0.26473 1.25 down Mm.18728 AI316828 103400_at D50523 expressed sequence AI3168285231 0.26476 1.55 up Mm.1485 Ube2e3 93033_at X92664 ubiquitin-conjugating enzyme E2E 3, UBC4/5 homolog (yeast)5232 0.26488 1.60 up Mm.29008 Iigp-pending 103963_f_at AA914345 interferon-inducible GTPase5233 0.26491 2.12 up Mm.219522 Sang 160097_at AF085738 Sang5234 0.26491 1.36 down Mm.14097 Tapbp 100154_at AI836367 TAP binding protein5235 0.26493 2.16 up Mm.712 Tncc 101063_at M29793 troponin C, cardiac/slow skeletal5236 0.26499 5.30 up Mm.35439 Sparc 97160_at X04017 secreted acidic cysteine rich glycoprotein5237 0.26511 1.80 down Mm.18709 Sgca 103395_at AF019564 sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)5238 0.26511 2.20 up Mm.1791 Dusp6 161536_r_at AV235001 dual specificity phosphatase 65239 0.26515 1.22 down Mm.10288 Atp9a 160577_at AF011336 ATPase, class II, type 9A5240 0.26525 3.08 up Mm.27822 Apobec2 97235_f_at AW124988 apolipoprotein B editing complex 25241 0.26533 1.28 up Mm.88846 Olfr71 97004_at AJ133429 olfactory receptor 715242 0.26534 1.41 up Mm.1431 Shbg 100702_at U85644 sex hormone binding globulin5243 0.26535 1.73 up Mm.35019 Mm.35019 96532_at AA212897 ESTs5244 0.26539 1.49 up Mm.22753 Ctsb 94831_at M65270 cathepsin B5245 0.26544 1.55 up Mm.1775 Hn1 93276_at U90123 hematological and neurological expressed sequence 15246 0.26555 1.47 up Mm.28885 AI834976 104413_at AI834976 expressed sequence AI8349765247 0.26556 1.48 up Mm.8 Usf1 93655_at X95316 upstream transcription factor 15248 0.26558 1.14 down Mm.28077 6720456B07Rik 97311_at AI836509 RIKEN cDNA 6720456B07 gene5249 0.26563 1.59 down Mm.5381 Mrpl45 95556_at AI841364 mitochondrial ribosomal protein L455250 0.26568 1.76 down Mm.20273 2900073H19Rik 103624_at AW121323 RIKEN cDNA 2900073H19 gene5251 0.26572 1.84 down Mm.8359 Pklr 101472_s_at AI195164 pyruvate kinase liver and red blood cell5252 0.26582 1.53 up Mm.26938 Klf2 96109_at U25096 Kruppel-like factor 2 (lung)5253 0.26589 1.16 up Mm.21054 Nsep1 93740_at U33196 nuclease sensitive element binding protein 15254 0.26592 1.91 up Mm.148395 Lamb1-1 162263_f_at AV357656 laminin B1 subunit 15255 0.26593 2.01 up Mm.108076 Pfkp 97834_g_at AI853802 phosphofructokinase, platelet5256 0.26617 1.25 down Mm.2597 Sod2 96042_at L35528 superoxide dismutase 2, mitochondrial5257 0.26620 1.48 down Mm.29869 2410002J21Rik 160367_at AW125223 RIKEN cDNA 2410002J21 gene5258 0.26628 1.28 down Mm.24569 Mm.24569 103756_at AA832886 ESTs, Weakly similar to T31511 hypothetical protein Y116A8C.9 - Caenorha5259 0.26638 1.55 up Mm.28362 AI326478 100683_r_at U62386 expressed sequence AI3264785260 0.26640 1.68 up Mm.632 Tnnt2 100593_at L47600 troponin T2, cardiac5261 0.26648 1.90 up Mm.969 Mm.969 162242_at AV170661 ESTs5262 0.26655 5.68 up Mm.3171 Sfrp1 97997_at U88566 secreted frizzled-related sequence protein 15263 0.26660 2.19 up Mm.30144 Ctla2a 162421_r_at AV290484 cytotoxic T lymphocyte-associated protein 2 alpha5264 0.26666 1.74 up Mm.22742 Fxyd2 94827_at X70060 FXYD domain-containing ion transport regulator 25265 0.26667 1.35 down Mm.154309 Rev1l 98142_at AA930290 REV1-like (S. cerevisiae)5266 0.26672 1.58 up Mm.29088 0610013D04Rik 96786_s_at AA879929 RIKEN cDNA 0610013D04 gene5267 0.26676 1.56 up Mm.27619 0610012A05Rik 104206_at AA815845 RIKEN cDNA 0610012A05 gene5268 0.26677 1.55 down Mm.204508 AA407331 98340_at AA407332 expressed sequence AA4073315269 0.26681 1.55 down 101561_at K022365270 0.26681 1.20 down Mm.20828 Epc1 103263_at AF079765 enhancer of polycomb homolog 1, (Drosophila)5271 0.26683 1.91 up Mm.12559 Hs3st1 102410_at AF019385 heparan sulfate (glucosamine) 3-O-sulfotransferase 15272 0.26687 1.23 down Mm.38930 AA407558 104683_at AW120783 expressed sequence AA4075585273 0.26690 1.93 up Mm.29164 2310021G01Rik 95063_at AI606257 RIKEN cDNA 2310021G01 gene5274 0.26690 1.14 down Mm.41541 Ict1 99150_at AI844357 immature colon carcinoma transcript 15275 0.26699 1.50 up Mm.24640 Grb10 93690_at AF022072 growth factor receptor bound protein 105276 0.26713 1.99 up Mm.10104 Hmx1 94102_at AF009614 H6 homeo box 15277 0.26716 1.82 down Mm.41747 Mm.41747 161030_at AW124134 Mus musculus 10, 11 days embryo whole body cDNA, RIKEN full-length enr5278 0.26720 1.25 down Mm.138450 D17H6S45 92610_at M21332 DNA segment, Chr 17, human D6S455279 0.26731 1.34 up Mm.6974 Krt1-14 101642_at J02644 keratin complex 1, acidic, gene 145280 0.26735 1.32 down Mm.29493 Wdr6 95643_at AW050287 WD repeat domain 65281 0.26738 1.98 down Mm.195089 V2r5 95799_s_at AF011415 vomeronasal 2, receptor, 55282 0.26746 2.07 up Mm.620 Arsa 161286_f_at AV025111 arylsulfatase A5283 0.26748 1.80 up Mm.25108 D2Ertd357e 96394_at C81245 DNA segment, Chr 2, ERATO Doi 357, expressed5284 0.26749 1.31 up Mm.28347 MGC7589 97873_at AI837563 putative inorganic polyphosphate/ATP-NAD kinase5285 0.26759 1.63 up Mm.36775 Ndr3 98554_at AB033922 N-myc downstream regulated 35286 0.26760 1.23 down Mm.24236 Mm.24236 104621_at AW046060 ESTs, Highly similar to T00268 hypothetical protein KIAA0597 [H.sapiens]5287 0.26767 1.20 up Mm.26789 Csnk2b 96099_at X56502 casein kinase II, beta subunit5288 0.26767 1.22 down Mm.1396 Slc30a3 102683_at U76009 solute carrier family 30 (zinc transporter), member 35289 0.26768 3.98 up 94516_f_at M551815290 0.26769 1.94 up Mm.5193 Klk8 161346_f_at AV145185 kallikrein 85291 0.26769 1.43 down Mm.1608 Awp1-pending 93082_at AW124081 associated with Prkcl15292 0.26772 2.07 up Mm.27856 Ptprk 161371_r_at AV240021 protein tyrosine phosphatase, receptor type, K5293 0.26776 1.27 up Mm.2821 6530401N04Rik 104242_f_at AI835622 RIKEN cDNA 6530401N04 gene5294 0.26780 1.98 up Mm.1348 X61497 102777_at X61497 hypothetical protein, I545295 0.26786 1.42 up Mm.24193 Gpc1 104614_at AI852765 glypican 15296 0.26792 1.97 down Mm.2395 Mea1 94890_at D17341 male enhanced antigen 15297 0.26798 1.68 up Mm.13885 Tnfrsf4 102681_at Z21674 tumor necrosis factor receptor superfamily, member 45298 0.26798 1.90 up Mm.4767 Gast 98797_at U34293 gastrin5299 0.26802 1.77 down Mm.133797 Magea5 93868_at AL021127 melanoma antigen, family A, 55300 0.26805 1.78 up Mm.22663 Sqle 161274_at AV324302 squalene epoxidase5301 0.26808 1.94 up Mm.34819 Itih4 98467_at AF023919 inter alpha-trypsin inhibitor, heavy chain 45302 0.26810 1.56 up Mm.141758 Hba-x 100549_at M13125 hemoglobin X, alpha-like embryonic chain in Hba complex5303 0.26815 1.28 down Mm.27518 catp 95029_at AW046747 cation-transporting atpase5304 0.26879 1.49 down Mm.3986 Ghr 99108_s_at U15012 growth hormone receptor5305 0.26887 1.39 down Mm.30155 Atp6l 96919_at M64298 ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16 kDa5306 0.26887 1.42 up Mm.17912 Biklk 93288_at AI835883 Bcl2-interacting killer-like5307 0.26891 1.20 down Mm.41864 1190005K07Rik 104715_at AI152779 RIKEN cDNA 1190005K07 gene5308 0.26901 1.84 up Mm.28263 Clecsf9 96551_at AB024717 C-type (calcium dependent, carbohydrate recognition domain) lectin, superfa5309 0.26902 1.25 up Mm.4055 Mm.4055 92388_at AW045528 Mus musculus, clone IMAGE:5102177, mRNA, partial cds5310 0.26910 1.60 up Mm.21840 4930542G03Rik 94016_at AW124905 RIKEN cDNA 4930542G03 genePage 59 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description5311 0.26917 1.41 up Mm.19799 6130401J04Rik 103582_r_at AI845633 RIKEN cDNA 6130401J04 gene5312 0.26920 1.41 down Mm.89136 H3f3a 100380_at X91866 H3 histone, family 3A5313 0.26920 1.92 up Mm.250 Gbp1 95974_at M55544 guanylate nucleotide binding protein 15314 0.26927 2.45 up Mm.7025 Mm.7025 101671_at AA591039 EST5315 0.26941 1.83 down Mm.34949 C81431 97148_at C81567 expressed sequence C814315316 0.26946 2.23 up Mm.5102 Syt2 101183_at D37793 synaptotagmin 25317 0.26948 1.95 up Mm.35692 Il1rl1 98500_at D13695 interleukin 1 receptor-like 15318 0.26948 1.81 up Mm.2611 Otc 94414_at X07092 ornithine transcarbamylase5319 0.26968 1.39 down Mm.4123 Kcnma1 97759_at U09383 potassium large conductance calcium-activated channel, subfamily M, alpha5320 0.26975 1.69 up Mm.27289 1600023A02Rik 161477_r_at AV019597 RIKEN cDNA 1600023A02 gene5321 0.26976 2.12 up Mm.42225 Klf12 102088_at Y14295 Kruppel-like factor 125322 0.26977 1.75 up Mm.12980 ICRFP703B1614Q5.6 102640_at AI157795 predicted gene ICRFP703B1614Q5.65323 0.26977 1.34 down Mm.34356 AW555115 98057_at AW121162 expressed sequence AW5551155324 0.26977 1.32 down Mm.28839 D5Ertd406e 94462_at AW120719 DNA segment, Chr 5, ERATO Doi 406, expressed5325 0.26978 2.16 down Mm.88761 Tbx14 100355_g_at AF013282 T-box 145326 0.26980 1.21 up Mm.30158 0710001O03Rik 160391_at AI853364 RIKEN cDNA 0710001O03 gene5327 0.27015 1.41 up Mm.21697 5830413E08Rik 103460_at AI849939 RIKEN cDNA 5830413E08 gene5328 0.27024 1.98 up Mm.5519 D15Ertd30e 99358_at C76643 DNA segment, Chr 15, ERATO Doi 30, expressed5329 0.27038 1.17 down Mm.156892 Hnrpd 94303_at U11274 heterogeneous nuclear ribonucleoprotein D5330 0.27044 1.23 down Mm.27526 2610011N19Rik 96693_at AI849453 RIKEN cDNA 2610011N19 gene5331 0.27045 2.22 up Mm.142727 Prg2 161048_at AV146057 proteoglycan 2, bone marrow5332 0.27047 1.58 down Mm.5337 AI852629 93168_at AI852629 expressed sequence AI8526295333 0.27058 4.92 up Mm.45436 Lyzs 100611_at M21050 lysozyme5334 0.27062 1.69 up Mm.1569 Casp11 102905_at Y13089 caspase 115335 0.27068 1.22 up Mm.16783 Pgam1 160091_at AW125401 phosphoglycerate mutase 15336 0.27069 1.91 up Mm.7445 AW491150 99870_at AA080253 expressed sequence AW4911505337 0.27085 1.23 down Mm.155696 Bet1l 98052_at AF003999 blocked early in transport 1 homolog (S. cerevisiae)-like5338 0.27098 2.16 up Mm.88881 Mm.88881 100378_at AI467488 ESTs, Weakly similar to JAK3 MOUSE TYROSINE-PROTEIN KINASE JAK35339 0.27103 1.73 up Mm.87782 Klra8 100326_f_at U12889 killer cell lectin-like receptor, subfamily A, member 85340 0.27104 1.23 down Mm.23744 BC002236 94865_at AW050059 hypothetical protein, MGC: 75135341 0.27112 1.34 up Mm.2209 Cd4 98965_at AC002397 CD4 antigen5342 0.27127 1.55 up Mm.2390 Cited1 160705_at U65091 Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal doma5343 0.27134 1.40 down Mm.43331 Sfrs5 99628_at AF020308 splicing factor, arginine/serine-rich 5 (SRp40, HRS)5344 0.27138 1.68 down Mm.745 Fnbp4 101422_at AW121377 formin binding protein 45345 0.27145 1.58 down Mm.183073 Immt 100589_at AW047808 inner membrane protein, mitochondrial5346 0.27152 1.76 up Mm.24470 5830436K05Rik 95915_at AA409520 RIKEN cDNA 5830436K05 gene5347 0.27165 1.84 up Mm.30602 Mm.30602 97960_at AW125800 ESTs, Weakly similar to UBP2_MOUSE UBIQUITIN CARBOXYL-TERMINAL5348 0.27175 1.66 up Mm.12815 Rab5b 98731_at X84239 RAB5B, member RAS oncogene family5349 0.27189 1.67 up Mm.99965 D1Lub1 101845_s_at M55219 DNA segment, Chr 1, Lubeck 15350 0.27202 1.41 up Mm.4557 Tlk2 100014_at AI845038 tousled-like kinase 2 (Arabidopsis)5351 0.27208 1.35 up Mm.33263 H2-D1 97541_f_at X00246 histocompatibility 2, D region locus 15352 0.27208 2.40 up Mm.21138 Nufip1 161685_r_at AV215254 nuclear fragile X mental retardation protein interacting protein5353 0.27211 1.40 up Mm.157931 Rcvrn 101151_at X66196 recoverin5354 0.27213 1.45 down Mm.202295 AW060714 104119_at AI845028 expressed sequence AW0607145355 0.27215 1.32 down Mm.3318 E4f1 104689_at X76858 E4F transcription factor 15356 0.27223 1.65 up Mm.193091 Mm.193091 161710_r_at AV245646 Mus musculus, clone IMAGE:3708675, mRNA, partial cds5357 0.27226 3.11 up Mm.9336 Gnb4 93949_at M63658 guanine nucleotide binding protein, beta 45358 0.27227 1.39 up Mm.29571 1200017E04Rik 95664_at AW048159 RIKEN cDNA 1200017E04 gene5359 0.27228 1.66 up Mm.34106 AI467657 92201_at AI553024 expressed sequence AI4676575360 0.27229 1.74 down Mm.1232 Mm.1232 92779_f_at Z22552 Mus musculus, clone MGC:8060 IMAGE:3587523, mRNA, complete cds5361 0.27231 1.27 down Mm.46797 Adrb1 93193_at X15643 adrenergic receptor, beta 15362 0.27232 2.67 up Mm.35613 C78344 97170_at C78163 expressed sequence C783445363 0.27247 1.30 down Mm.196325 C80342 160313_at AW046691 expressed sequence C803425364 0.27252 1.68 up Mm.3064 Elk1 96593_at X87257 ELK1, member of ETS oncogene family5365 0.27258 1.64 down Mm.157324 AI225782 99949_at AW060324 expressed sequence AI2257825366 0.27276 1.60 up Mm.29680 1700003K02Rik 97364_at AW213865 RIKEN cDNA 1700003K02 gene5367 0.27276 1.26 down Mm.21501 0610041L09Rik 93815_at AI839425 RIKEN cDNA 0610041L09 gene5368 0.27289 1.45 down Mm.828 Rag1 161740_r_at AV316109 recombination activating gene 15369 0.27297 1.43 up Mm.25549 1700016A15Rik 161352_r_at AV172838 RIKEN cDNA 1700016A15 gene5370 0.27303 1.76 up Mm.196407 Igk-V21 96971_f_at X00652 immunoglobulin kappa chain variable 21 (V21)5371 0.27309 1.24 down Mm.27496 Mm.27496 160234_at AI848382 Mus musculus, Similar to ubiquitin specific protease 1, clone MGC:25528 IM5372 0.27310 1.67 down Mm.3174 Lifr 104659_g_at D17444 leukemia inhibitory factor receptor5373 0.27314 1.33 up Mm.34832 Lapep-pending 98112_r_at AI839225 leucine aminopeptidase5374 0.27316 2.09 up 92541_at X129735375 0.27329 1.23 down Mm.5938 Myh9 100915_at AW125698 myosin heavy chain IX5376 0.27354 1.62 down Mm.2664 Prrg2 162142_f_at AV350073 proline-rich Gla (G-carboxyglutamic acid) polypeptide 25377 0.27363 1.57 up Mm.6500 Kl 100956_at AB005141 klotho5378 0.27369 1.68 down Mm.6660 Scya27 100973_i_at AA672499 small inducible cytokine A275379 0.27370 2.12 down Mm.4909 Cbfa2t1h 92935_at D32007 CBFA2T1 identified gene homolog (human)5380 0.27372 1.56 up Mm.4709 Wnt10b 92752_r_at U61970 wingless related MMTV integration site 10b5381 0.27375 1.91 up Mm.6219 Galr1 99837_at U90657 galanin receptor 15382 0.27378 2.43 up Mm.89850 Nrk 93919_at AB020741 Nik related kinase5383 0.27380 1.88 up Mm.4778 Cspg3 102477_at AW121443 chondroitin sulfate proteoglycan 35384 0.27383 1.91 up Mm.17339 Sult1a1 162130_r_at AV378535 sulfotransferase family 1A, phenol-preferring, member 15385 0.27387 1.72 up Mm.6203 Gp1ba 101620_at U91967 glycoprotein 1b, alpha polypeptide5386 0.27412 1.66 up Mm.3257 Gas7 104678_at U19860 growth arrest specific 75387 0.27427 1.93 up Mm.5095 Sca1 98854_at X83542 spinocerebellar ataxia 1 homolog (human)5388 0.27428 1.51 up Mm.24489 AA408396 94667_at AA408396 expressed sequence AA4083965389 0.27439 1.34 down Mm.1151 Dpp4 92634_at U12620 dipeptidylpeptidase 45390 0.27443 1.31 down Mm.28373 Bag3 96167_at AI643420 Bcl2-associated athanogene 35391 0.27459 1.49 down Mm.40282 Mm.40282 99441_at AW123852 Mus musculus, Similar to gephyrin, clone MGC:38765 IMAGE:5358943, mR5392 0.27461 2.32 up Mm.252 Nqo1 94351_r_at U12961 NAD(P)H dehydrogenase, quinone 15393 0.27472 1.55 down Mm.4881 Pcsk1n 100139_at AI841733 proprotein convertase subtilisin/kexin type 1 inhibitor5394 0.27473 1.66 up Mm.89926 Polk 97651_at AB027563 polymerase (DNA directed) kappa5395 0.27491 1.29 up Mm.117581 Ncl 100144_at X07699 nucleolin5396 0.27495 1.64 up Mm.200673 Lasp1 93930_at U58882 LIM and SH3 protein 15397 0.27500 1.26 up Mm.3195 Hsd17b4 97515_at X89998 hydroxysteroid 17-beta dehydrogenase 45398 0.27501 1.57 up Mm.23975 2400007G07Rik 104581_at AI845438 RIKEN cDNA 2400007G07 gene5399 0.27505 1.57 up Mm.1239 Gfap 94143_at X02801 glial fibrillary acidic protein5400 0.27510 1.87 down Mm.21579 H2bfs 161394_f_at AV261084 H2B histone family, member SPage 60 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description5401 0.27526 1.80 up Mm.27900 1810013D10Rik 161435_i_at AV345278 RIKEN cDNA 1810013D10 gene5402 0.27533 2.12 up Mm.10742 Cyp4a10 92600_f_at AB018421 cytochrome P450, 4a105403 0.27536 1.72 up Mm.34162 Mm.34162 92206_at AA985828 ESTs, Weakly similar to 1615347A ras p21 GTPase activating protein [M.mu5404 0.27540 1.53 up Mm.534 Igfbp7 160527_at AB012886 insulin-like growth factor binding protein 75405 0.27552 3.82 up Mm.140186 Eif4ebp2 96729_at AI848377 eukaryotic translation initiation factor 4E binding protein 25406 0.27557 1.51 up Mm.2937 2310035K24Rik 96819_at AW060875 RIKEN cDNA 2310035K24 gene5407 0.27564 1.97 up Mm.22876 AI035728 162221_i_at AV112892 expressed sequence AI0357285408 0.27567 1.67 up Mm.5706 Mm.5706 161810_r_at AV372413 ESTs, Moderately similar to S12207 hypothetical protein [M.musculus]5409 0.27580 1.40 up Mm.35235 R74626 97158_at AI840785 expressed sequence R746265410 0.27584 1.90 up Mm.1825 Tff2 93302_at U78770 trefoil factor 2 (spasmolytic protein 1)5411 0.27585 1.20 up Mm.18675 Hprt 160107_at K01515 hypoxanthine guanine phosphoribosyl transferase5412 0.27588 1.36 down Mm.3576 Cct3 98153_at L20509 chaperonin subunit 3 (gamma)5413 0.27601 2.09 up Mm.34248 Dab2 104633_at AW123921 disabled homolog 2 (Drosophila)5414 0.27607 2.37 up Mm.22876 AI035728 162179_r_at AV367224 expressed sequence AI0357285415 0.27616 2.01 up Mm.28704 Sec23b 161939_f_at AV335340 SEC23B (S. cerevisiae)5416 0.27617 1.38 up Mm.41522 Zfh4-pending 98760_at L36173 zinc finger homeodomain 45417 0.27620 1.25 up Mm.41390 Mrpl16 99140_at AW124920 mitochondrial ribosomal protein L165418 0.27623 1.60 up Mm.4781 Cyp7b1 92898_at U36993 cytochrome P450, 7b15419 0.27630 1.41 up Mm.3077 Nr1i3 104507_g_at AF009328 nuclear receptor subfamily 1, group I, member 35420 0.27634 1.41 up Mm.7363 Spnb3 93618_at AF026489 beta-spectrin 35421 0.27648 2.13 up Mm.31730 2610020P18Rik 161017_at AI450066 RIKEN cDNA 2610020P18 gene5422 0.27650 1.55 up Mm.5091 Spock1 161054_at X92864 sparc/osteonectin, cwcv and kazal-like domains proteoglycan 15423 0.27659 1.35 up Mm.12914 Usp2 92821_at AF079565 ubiquitin specific protease 25424 0.27665 2.25 up Mm.27339 5430411C10Rik 96654_at AI852916 RIKEN cDNA 5430411C10 gene5425 0.27674 1.82 up Mm.16469 Nmyc1 103048_at M12731 neuroblastoma myc-related oncogene 15426 0.27692 1.30 down Mm.30141 Gnb2 96911_at U34960 guanine nucleotide binding protein, beta 25427 0.27693 1.50 down Mm.127823 C77662 161760_s_at AV330213 expressed sequence C776625428 0.27716 1.46 up Mm.10283 Pdk4 102049_at AJ001418 pyruvate dehydrogenase kinase 45429 0.27725 1.89 up Mm.2018 Cbfb 104653_at AA864065 core binding factor beta5430 0.27734 17.43 up Mm.14868 Gzmg 102876_at J02872 granzyme G5431 0.27737 1.35 down Mm.16340 Fgfr2 93091_s_at M63503 fibroblast growth factor receptor 25432 0.27745 1.40 up Mm.35302 2010004A03Rik 94802_at AI846678 RIKEN cDNA 2010004A03 gene5433 0.27750 2.02 up Mm.21147 C80347 95353_at C80670 expressed sequence C803475434 0.27750 2.52 down Mm.30557 Tcra 97945_at M16118 T-cell receptor alpha chain5435 0.27750 1.28 up Mm.2972 Mm.2972 96569_at AA266298 ESTs5436 0.27763 1.24 up Mm.20845 Abcc5a 103800_at AB019003 ATP-binding cassette, sub-family C (CFTR/MRP), member 5a5437 0.27773 1.86 up Mm.29106 Prss15 92684_at AW122725 protease, serine, 155438 0.27776 1.61 up Mm.20193 Adcy4 95308_at AA397054 adenylate cyclase 45439 0.27783 2.87 up Mm.27685 Mm.27685 95542_at AI835858 ESTs, Moderately similar to TROPOMYOSIN 5, CYTOSKELETAL TYPE [M.5440 0.27792 1.33 up Mm.10508 Ssb 92579_at L00993 Sjogren syndrome antigen B5441 0.27794 1.25 up Mm.14097 Tapbp 162104_f_at AV361189 TAP binding protein5442 0.27799 1.44 up Mm.172842 Mm.172842 102102_at C80410 ESTs, Weakly similar to POL2 MOUSE RETROVIRUS-RELATED POL POLY5443 0.27805 1.31 up Mm.29971 Snx2 96331_at AI842754 sorting nexin 25444 0.27806 1.29 down Mm.3830 Fpgs 160850_at U32197 folylpolyglutamyl synthetase5445 0.27809 1.96 up Mm.55075 2810025N20Rik 160737_at AW060927 RIKEN cDNA 2810025N20 gene5446 0.27816 1.34 up Mm.2854 Tff1 160300_at Z21858 trefoil factor 15447 0.27819 1.57 up Mm.30193 Uae1 97924_at AJ132236 UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase5448 0.27827 1.56 up Mm.87594 Ches1 104665_g_at AA725931 checkpoint suppressor 15449 0.27831 1.22 up Mm.29708 D4Wsu114e 162036_r_at AV260585 DNA segment, Chr 4, Wayne State University 114, expressed5450 0.27842 1.30 up Mm.27375 Mt1a 95003_at AA880275 metallothionein-I activator5451 0.27843 2.13 down Mm.206715 Btbd1 94877_at AI848446 BTB (POZ) domain containing 15452 0.27857 1.47 down Mm.27897 Dnaja1 97261_at AF055664 DnaJ (Hsp40) homolog, subfamily A, member 15453 0.27858 1.29 up Mm.24875 Mrps18a 161767_r_at AV339603 mitochondrial ribosomal protein S18A5454 0.27864 1.15 down Mm.21251 Dp1 103886_at AI850356 deleted in polyposis 15455 0.27881 1.45 up Mm.8009 Ptrf 99901_at AF036249 polymerase I and transcript release factor5456 0.27882 1.37 down Mm.206051 Mm.206051 104561_at AW120990 Mus musculus, Similar to general transcription factor IIIC, polypeptide 5 (63k5457 0.27886 2.74 up Mm.1585 Tm7sf1 103923_at AA656014 transmembrane 7 superfamily member 15458 0.27888 1.78 up Mm.42100 Cyp2c38 102084_f_at AF047725 cytochrome P450, 2c385459 0.27889 1.18 down Mm.206715 Btbd1 94878_at AW125224 BTB (POZ) domain containing 15460 0.27894 1.81 down Mm.37835 Rpl7 97697_at X57960 ribosomal protein L75461 0.27895 2.02 up Mm.181709 Rgs16 161609_at AV349152 regulator of G-protein signaling 165462 0.27903 1.40 down Mm.2602 Hdac1 96046_at X98207 histone deacetylase 15463 0.27903 1.62 up Mm.22700 Gtf2h1 94811_s_at AJ002366 general transcription factor II H, polypeptide 1 (62kD subunit)5464 0.27904 1.85 up Mm.16549 Pold1 161528_r_at AV227261 DNA polymerase delta 1, catalytic domain5465 0.27914 1.88 up Mm.679 Rom1 161525_f_at AV356715 rod outer segment membrane protein 15466 0.27917 1.59 up Mm.29063 2410022L05Rik 161906_f_at AV113045 RIKEN cDNA 2410022L05 gene5467 0.27918 1.62 up Mm.39728 Celsr2 92363_at AI586083 cadherin EGF LAG seven-pass G-type receptor 25468 0.27927 2.13 down Mm.913 T 93941_at X51683 brachyury5469 0.27927 1.69 up Mm.1123 Wnt1 94134_at M11943 wingless-related MMTV integration site 15470 0.27946 1.30 down Mm.28184 2210408E11Rik 104241_at AI854379 RIKEN cDNA 2210408E11 gene5471 0.27947 1.27 down Mm.12166 AU018108 102381_at AA619207 expressed sequence AU0181085472 0.27948 1.21 down Mm.368 Psmb4 98557_f_at U65636 proteasome (prosome, macropain) subunit, beta type 45473 0.27950 1.25 down Mm.7500 Ftl1 99872_s_at L39879 ferritin light chain 15474 0.27951 1.45 up Mm.22661 2810409H07Rik 160166_r_at AI843495 RIKEN cDNA 2810409H07 gene5475 0.27957 1.29 down Mm.10009 D4Wsu53e 92542_at AI849035 DNA segment, Chr 4, Wayne State University 53, expressed5476 0.27958 2.04 up Mm.20988 Myt1 95347_at AF004294 myelin transcription factor 15477 0.27976 1.18 up Mm.20922 Map2k1ip1 160126_at AF082526 mitogen-activated protein kinase kinase 1 interacting protein 15478 0.27993 1.36 down Mm.24521 AA407930 160713_at AI841579 expressed sequence AA4079305479 0.28018 1.15 up Mm.42197 Psmb1 160875_at AF090314 proteasome (prosome, macropain) subunit, beta type 15480 0.28037 2.27 up Mm.6559 Asgr1 161566_r_at AV268262 asialoglycoprotein receptor 15481 0.28045 1.74 up Mm.603 Snrpd1 100577_at M58558 small nuclear ribonucleoprotein D15482 0.28058 1.40 up Mm.171292 2010200I23Rik 160179_at AW124122 RIKEN cDNA 2010200I23 gene5483 0.28069 1.51 up Mm.1945 Pip5k1a 101649_at AF048695 phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha5484 0.28079 1.24 down Mm.24703 AA408880 95457_at AI854214 expressed sequence AA4088805485 0.28088 1.70 up Mm.5046 Ptprj 92985_at D83203 protein tyrosine phosphatase, receptor type, J5486 0.28092 1.33 down Mm.28710 AI429613 96221_at AI606300 expressed sequence AI4296135487 0.28107 1.29 up Mm.55982 4930522D07Rik 160856_at J04761 RIKEN cDNA 4930522D07 gene5488 0.28121 1.53 down Mm.39473 Pcbd 99056_at AW046590 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuc5489 0.28125 1.43 up Mm.4098 Sca10 160981_at AI837246 spinocerebellar ataxia 10 homolog (human)5490 0.28140 1.67 up 102622_r_at AJ011106Page 61 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description5491 0.28144 2.50 up Mm.23803 Gcnt2 95392_at U68182 glucosaminyltransferase, I-branching enzyme5492 0.28145 1.88 up Mm.4771 Nfia 92894_s_at D90174 nuclear factor I/A5493 0.28147 1.35 down Mm.29827 Snd1-pending 96260_at AB021491 staphylococcal nuclease domain containing 15494 0.28153 1.26 down Mm.38343 Mapk12 92323_at Y13439 mitogen-activated protein kinase 125495 0.28156 1.29 up Mm.1393 Ung 102792_at U55040 uracil-DNA glycosylase5496 0.28159 1.72 up Mm.56897 Artn 101278_at AF109402 artemin5497 0.28162 2.30 up Mm.56945 Pou3f2 99385_at M88300 POU domain, class 3, transcription factor 25498 0.28163 1.76 up Mm.39099 Zfp358 99044_at AI847547 zinc finger protein 3585499 0.28171 1.21 down Mm.29499 Cpt2 95646_at U01170 carnitine palmitoyltransferase 25500 0.28174 1.82 up Mm.212716 Mm.212716 93927_f_at L33954 Mus musculus mRNA for immunoglobulin heavy chain, mAb 6675501 0.28181 1.32 down Mm.9488 Clk4 101936_at AF033566 CDC like kinase 45502 0.28189 1.23 down Mm.27477 2010100O12Rik 96687_f_at AI853864 RIKEN cDNA 2010100O12 gene5503 0.28191 1.59 down Mm.25794 Fbxl5 96031_r_at AW259411 f-box and leucine-rich repeat protein 55504 0.28194 1.69 up Mm.15630 Six3 102900_at X90871 sine oculis-related homeobox 3 homolog (Drosophila)5505 0.28197 1.32 down Mm.23470 Mm.23470 95387_f_at AA266467 ESTs5506 0.28205 1.49 up Mm.181959 Egr1 98579_at M28845 early growth response 15507 0.28206 1.59 down Mm.24084 1300019H17Rik 104600_at AI841692 RIKEN cDNA 1300019H17 gene5508 0.28220 1.35 down Mm.28251 Tulp4 160775_at AI848591 tubby like protein 45509 0.28228 1.46 up Mm.465 Sdf1 100112_at L12030 stromal cell derived factor 15510 0.28230 2.03 up Mm.22506 G7e-pending 162344_at AV149386 G7e protein5511 0.28231 1.26 up Mm.196538 Rps11 94767_at U93864 ribosomal protein S115512 0.28235 1.41 down Mm.3465 Epb4.1l4a 161603_r_at AV308245 erythrocyte protein band 4.1-like 4a5513 0.28237 1.19 up Mm.30243 Mm.30243 97446_at AW125010 Mus musculus mRNA for HELG, complete cds5514 0.28242 1.28 down Mm.182440 Apoc1 93354_at Z22661 apolipoprotein CI5515 0.28243 1.62 down Mm.6973 Krtap6-1 101375_at D86421 keratin associated protein 6-15516 0.28245 1.46 up Mm.18087 Lgals9 161301_f_at AV049898 lectin, galactose binding, soluble 95517 0.28276 1.66 up Mm.12916 Zfp54 102626_r_at AF080070 zinc finger protein 545518 0.28276 1.18 down Mm.28422 C78339 97897_at AI848435 expressed sequence C783395519 0.28279 1.20 down Mm.2040 Glb1 161754_f_at AV292258 galactosidase, beta 15520 0.28280 2.97 up Mm.57151 Magea7 101808_at AJ005531 melanoma antigen, family A, 75521 0.28283 1.63 up Mm.39039 Irx3 99034_at Y15001 iroquois related homeobox 3 (Drosophila)5522 0.28298 1.97 up Mm.57128 Ifna4 101789_i_at X01973 interferon alpha family, gene 45523 0.28301 1.81 up Mm.27448 Nrp 95016_at D50086 neuropilin5524 0.28303 2.13 up Mm.196085 Igh-4 101870_at V00793 immunoglobulin heavy chain 4 (serum IgG1)5525 0.28303 1.52 up Mm.754 Ace 101428_at J04947 angiotensin converting enzyme5526 0.28306 2.11 up Mm.30806 Rpl19 161961_at AV366598 ribosomal protein L195527 0.28306 2.07 up Mm.182628 Rad21 161095_i_at D49429 RAD21 homolog (S. pombe)5528 0.28307 1.17 down Mm.28437 2700038L12Rik 160293_at AI839817 RIKEN cDNA 2700038L12 gene5529 0.28310 1.32 up Mm.199871 AI447783 95881_f_at AI447783 expressed sequence AI4477835530 0.28313 2.02 up Mm.34425 Myh2 92218_at AJ002521 myosin, heavy polypeptide 2, skeletal muscle, adult5531 0.28320 1.21 down Mm.914 Cct7 160562_at Z31399 chaperonin subunit 7 (eta)5532 0.28349 1.48 up Mm.711 Tnnt1 101383_at AJ131711 troponin T1, skeletal, slow5533 0.28349 1.46 up Mm.6667 1210002E11Rik 100974_at AI844250 RIKEN cDNA 1210002E11 gene5534 0.28363 1.92 up Mm.7814 Dnmt1 161601_i_at AV302631 DNA methyltransferase (cytosine-5) 15535 0.28365 1.43 up Mm.83917 Mm.83917 161219_r_at AV250023 EST5536 0.28378 1.95 up Mm.5099 2310047B08Rik 160525_f_at AI324118 RIKEN cDNA 2310047B08 gene5537 0.28396 1.46 up Mm.57158 Cyln2 99432_at AJ228865 cytoplasmic linker 25538 0.28404 1.43 down Mm.22231 Sncg 161859_f_at AV062363 synuclein, gamma5539 0.28409 3.36 up Mm.43954 D13Ertd205e 102139_at C78750 DNA segment, Chr 13, ERATO Doi 205, expressed5540 0.28409 1.71 down Mm.12798 Pgr 98726_at M68915 progesterone receptor5541 0.28413 1.48 up Mm.3107 Nfatc3 97975_at D85612 nuclear factor of activated T-cells, cytoplasmic 35542 0.28415 2.33 up Mm.4500 Bdkrb2 98387_at L26047 bradykinin receptor, beta 25543 0.28416 4.07 up Mm.18888 Lum 93353_at AF013262 lumican5544 0.28430 1.81 down Mm.195060 H2-DMb2 101868_i_at X90807 histocompatibility 2, class II, locus Mb25545 0.28431 1.75 up Mm.14868 Gzmg 161690_at AV224140 granzyme G5546 0.28439 1.12 down Mm.27372 Ureb1-pending 96664_at AB025966 upstream regulatory element binding protein 15547 0.28451 1.81 up Mm.6891 Calb3 160918_at AF028071 calbindin-D9K5548 0.28476 1.94 up Mm.204796 Mm.204796 93282_at M11310 Mouse adenine phosphoribosyltransferase (APRT), complete cds5549 0.28477 1.41 down Mm.2402 Rhoip3-pending 94899_at U73200 Rho interacting protein 35550 0.28478 1.91 up Mm.4173 Ddx26 99171_at U57368 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 265551 0.28480 1.67 up Mm.24066 Mm.24066 95892_at AA189214 ESTs5552 0.28495 1.54 up Mm.41128 6230401O10Rik 99466_at AI845653 RIKEN cDNA 6230401O10 gene5553 0.28526 1.61 up Mm.29786 Mm.29786 95753_at AW213883 Mus musculus, clone MGC:36705 IMAGE:3673890, mRNA, complete cds5554 0.28531 1.59 up Mm.39728 Celsr2 92364_at AB028499 cadherin EGF LAG seven-pass G-type receptor 25555 0.28531 1.30 up Mm.27660 5730420G12Rik 97199_at AI854767 RIKEN cDNA 5730420G12 gene5556 0.28544 1.86 up Mm.23955 Wbscr5 103690_at AW125574 Williams-Beuren syndrome chromosome region 5 homolog (human)5557 0.28553 1.53 up Mm.3608 Pax6 92271_at X63963 paired box gene 65558 0.28564 1.31 up Mm.26580 Mm.26580 104000_at AI181346 Mus musculus, clone MGC:28542 IMAGE:4194872, mRNA, complete cds5559 0.28571 1.30 up Mm.36335 D1Wsu40e 95428_at AA688761 DNA segment, Chr 1, Wayne State University 40, expressed5560 0.28571 1.52 down Mm.2560 Rap2ip 103960_at U73941 Rap2 interacting protein5561 0.28574 1.60 up Mm.20634 Coq7 93582_at AF080580 demethyl-Q 75562 0.28581 1.33 up Mm.4941 Ndpp1 161228_f_at AV260677 NPC derived proline rich protein 15563 0.28586 1.57 up Mm.41902 5430423O14Rik 99190_at AI842824 RIKEN cDNA 5430423O14 gene5564 0.28587 1.56 up Mm.218186 Mm.218186 94095_at AI552528 ESTs, Weakly similar to RIKEN cDNA 5830411J07 [Mus musculus] [M.musc5565 0.28598 1.98 up Mm.153916 Adora2a 101364_at Y13344 adenosine A2a receptor5566 0.28602 1.27 up Mm.14767 H2afx 93019_at Z35401 H2A histone family, member X5567 0.28620 2.27 up Mm.8069 Col4a3 100285_at Z35166 procollagen, type IV, alpha 35568 0.28624 1.41 up Mm.22695 Crmp1 104383_at AB006714 collapsin response mediator protein 15569 0.28633 1.21 down Mm.22554 BC003945 104351_at AW120925 hypothetical protein BC0039455570 0.28634 2.65 up Mm.21815 C80453 103470_at AI596993 expressed sequence C804535571 0.28639 1.87 up Mm.9015 Gas11 93937_at U19859 growth arrest specific 115572 0.28652 2.17 up Mm.4925 Lyl1 100468_g_at X57687 lymphoblastomic leukemia5573 0.28661 1.16 down Mm.10374 2610002J02Rik 102056_f_at AA839379 RIKEN cDNA 2610002J02 gene5574 0.28673 1.60 up Mm.28362 AI326478 101157_at V00790 expressed sequence AI3264785575 0.28674 1.20 down Mm.22727 D17Wsu51e 104391_s_at AI850563 DNA segment, Chr 17, Wayne State University 51, expressed5576 0.28685 1.53 down Mm.206842 C76213 97665_i_at C76213 expressed sequence C762135577 0.28685 1.78 up Mm.1682 Ptpns1 95803_at D85785 protein tyrosine phosphatase, non-receptor type substrate 15578 0.28704 1.88 up Mm.10815 Zfp143 102263_at U29513 zinc finger protein 1435579 0.28708 1.75 up Mm.196618 Il1rl1l 160061_at U41805 interleukin 1 receptor-like 1 ligand5580 0.28715 1.74 down Mm.218627 Ppil2 95111_i_at AW122632 peptidylprolyl isomerase (cyclophilin)-like 2Page 62 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description5581 0.28718 1.41 down Mm.28265 Mm.28265 97845_at AI463460 Mus musculus WD repeat protein BIG-3 mRNA, complete cds5582 0.28720 2.04 up Mm.25019 C79242 96367_at C79242 expressed sequence C792425583 0.28723 1.72 up Mm.4911 Cntn1 92936_at X14943 contactin 15584 0.28730 1.62 up Mm.42047 Mmp17 92461_at AB021224 matrix metalloproteinase 175585 0.28733 1.98 down Mm.3020 Pparg 97926_s_at U10374 peroxisome proliferator activated receptor gamma5586 0.28738 1.39 down Mm.3715 AA408384 160847_at AI845321 EST AA4083845587 0.28762 1.41 down Mm.28962 Facl2 94507_at U15977 fatty acid Coenzyme A ligase, long chain 25588 0.28767 2.24 down Mm.1286 Svp2 100689_at M35732 seminal vesicle protein 25589 0.28780 1.22 down Mm.34246 Calm1 96522_at M19381 calmodulin 15590 0.28791 1.97 up Mm.7516 Nasp 101108_at AF034610 nuclear autoantigenic sperm protein (histone-binding)5591 0.28795 1.63 up Mm.1329 Mad 94688_at X83106 Max dimerization protein5592 0.28808 1.61 up Mm.18635 Rgs10 160629_at AI847399 regulator of G-protein signalling 105593 0.28809 1.27 up Mm.9537 Lcn2 97339_at AI841159 lipocalin 25594 0.28825 1.20 up Mm.212981 AU041936 94022_at AI844754 expressed sequence AU0419365595 0.28826 1.32 up Mm.10717 Hap1 102323_at AJ002272 huntingtin-associated protein 15596 0.28830 3.25 up Mm.2183 Lsp1 104093_at D49691 lymphocyte specific 15597 0.28837 2.01 up Mm.24982 C78111 103794_i_at AA986114 expressed sequence C781115598 0.28840 1.49 up 93388_s_at U876195599 0.28861 1.45 up Mm.4658 Cdh3 162097_r_at AV322859 cadherin 35600 0.28872 1.79 up Mm.4223 Pdha2 99542_at M76728 pyruvate dehydrogenase E1 alpha 25601 0.28882 1.59 up Mm.87561 Mm.87561 161258_at AV322247 ESTs5602 0.28882 1.42 up Mm.143805 Mtlrp-pending 99534_at AJ243503 motilin-related peptide5603 0.28887 1.40 up Mm.932 Mm.932 101926_at L41495 Mus musculus DNA segment, Chr X, Celltech Chiroscience 3 (DXCch3), mR5604 0.28887 1.46 up Mm.14157 Mx2 102699_at J03368 myxovirus (influenza virus) resistance 25605 0.28894 1.30 down Mm.7103 Pbx2 101421_at AF030001 pre B-cell leukemia transcription factor 25606 0.28910 2.24 up Mm.24174 AI316495 161438_r_at AV349170 expressed sequence AI3164955607 0.28910 2.09 up Mm.56936 Grin2d 99382_at D12822 glutamate receptor, ionotropic, NMDA2D (epsilon 4)5608 0.28922 1.21 down Mm.3746 Naca 98571_s_at U48363 nascent polypeptide-associated complex alpha polypeptide5609 0.28927 1.30 up Mm.425 Hint 99581_at U60001 histidine triad nucleotide binding protein5610 0.28930 1.99 down Mm.4765 Hoxc9 92891_f_at X55318 homeo box C95611 0.28933 2.12 down Mm.1843 Hsp86-1 161869_i_at AV358673 heat shock protein, 86 kDa 15612 0.28936 1.44 up Mm.1546 Gna15 94753_at M80632 guanine nucleotide binding protein, alpha 155613 0.28942 1.19 up Mm.1032 Hspa4 92571_at D85904 heat shock 70 kDa protein 45614 0.28945 1.81 up Mm.5152 Dlx6 98866_at U67841 distal-less homeobox 65615 0.28946 1.32 up Mm.35738 Catns 98151_s_at Z17804 catenin src5616 0.28952 1.78 up Mm.24374 D10Bwg0629e 103734_at AA985771 DNA segment, Chr 10, Brigham & Women's Genetics 0629 expressed5617 0.28953 1.34 up Mm.265 Rps25 96071_at AI835709 ribosomal protein S255618 0.28953 2.24 up Mm.75467 Calcrl 97795_at AB015595 calcitonin receptor-like5619 0.28958 1.57 down Mm.57033 Mm.57033 96969_at V00779 M.musculus immunoglobulin kappa chain variable region5620 0.28961 1.46 up Mm.2986 AW146116 162226_r_at AV303935 expressed sequence AW1461165621 0.28963 1.52 up Mm.3975 Csnk 99065_at M10114 casein kappa5622 0.28964 2.71 up Mm.22061 Sema4a 161530_r_at AV250428 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) an5623 0.28964 1.21 down Mm.24529 1100001F19Rik 93491_f_at AI836623 RIKEN cDNA 1100001F19 gene5624 0.28979 2.50 up Mm.27227 5730469M10Rik 161735_r_at AV281129 RIKEN cDNA 5730469M10 gene5625 0.28982 1.72 up Mm.3823 Elavl2 92317_at U29088 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)5626 0.28990 1.23 up Mm.18460 Mm.18460 160625_f_at AA048058 Mus musculus, Similar to hypothetical protein FLJ13984, clone MGC:7995 IM5627 0.28992 1.27 up Mm.201596 AI118529 104197_at AI118529 expressed sequence AI1185295628 0.29005 2.18 up Mm.19353 LOC56304 102157_f_at M15520 recombinant antineuraminidase single chain Ig VH and VL domains5629 0.29007 1.73 down Mm.6834 Ifnar2 101015_s_at AF013486 interferon (alpha and beta) receptor 25630 0.29020 1.38 up Mm.28364 AA407901 104253_at AA692074 expressed sequence AA4079015631 0.29030 1.29 down Mm.27261 R75501 104176_at AI850941 expressed sequence R755015632 0.29034 1.83 up Mm.3193 Pkia 98004_at M63554 protein kinase inhibitor, alpha5633 0.29039 1.62 up Mm.12723 Arl4 92805_s_at Y12577 ADP-ribosylation-like 45634 0.29039 1.67 down Mm.3485 Hpxn 98116_at U89889 hemopexin5635 0.29039 1.93 up Mm.8075 Gabra3 94645_at M86568 gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 35636 0.29040 1.50 up Mm.18946 Ap2m1 162442_r_at AV349550 adaptor protein complex AP-2, mu15637 0.29051 2.90 up Mm.2968 Cntn3 96568_at L01991 contactin 35638 0.29057 1.42 up Mm.1330 Pou3f1 102652_at X56959 POU domain, class 3, transcription factor 15639 0.29060 2.17 up Mm.63836 1700024B05Rik 96387_at C80559 RIKEN cDNA 1700024B05 gene5640 0.29062 1.59 up Mm.46767 Gng2 100418_at AW123750 guanine nucleotide binding protein (G protein), gamma 2 subunit5641 0.29063 1.51 down Mm.29581 Hey1 101913_at AW214298 hairy/enhancer-of-split related with YRPW motif 15642 0.29071 1.31 up Mm.661 Tnp1 160533_r_at X12521 transition protein 15643 0.29074 1.80 down Mm.2374 Tac2 103548_at D14423 tachykinin 25644 0.29078 1.14 down Mm.28324 9130014I08Rik 96157_at AI839059 RIKEN cDNA 9130014I08 gene5645 0.29081 1.93 up Mm.200611 Spna1 103941_at U87455 alpha-spectrin 1, erythroid5646 0.29102 1.22 up Mm.29169 Nfs1 95065_at AJ222660 nitrogen fixation gene 1 (S. cerevisiae)5647 0.29103 1.50 up Mm.5166 AB030186 160904_at AI841484 hypothetical protein, clone 1-825648 0.29110 1.38 up Mm.21852 Ptk9l 94020_at Y17808 protein typrotein tyrosine kinase 9-like (A6-related protein)5649 0.29123 1.59 up Mm.219419 2900072D10Rik 160292_at AW123987 RIKEN cDNA 2900072D10 gene5650 0.29130 1.95 up Mm.150472 Dlx6as 97654_at AF022079 distal-less homeobox 6, antisense5651 0.29137 1.32 up Mm.27669 Snrpe 97200_f_at X65704 small nuclear ribonucleoprotein E5652 0.29137 1.35 down Mm.29771 Atp6a1 95746_at AW123765 ATPase, H+ transporting, lysosomal (vacuolar proton pump), alpha 70 kDa, i5653 0.29172 1.25 down Mm.2025 Smn 103620_s_at U77714 survival motor neuron5654 0.29180 1.44 down Mm.38193 Zfp292 99001_at AF017806 zinc finger protein 2925655 0.29192 2.27 down Mm.57045 Kcnma3 99410_at AF039213 potassium large conductance pH-sensitive channel, subfamily M, alpha mem5656 0.29208 1.51 up Mm.181482 Pard6a 92423_at AF070970 par-6 (partitioning defective 6,) homolog alpha (C. elegans)5657 0.29244 3.41 up Mm.4443 Cyp1b1 99979_at X78445 cytochrome P450, 1b1, benz[a]anthracene inducible5658 0.29247 1.47 up Mm.26610 3110027H23Rik 104004_at AI931876 RIKEN cDNA 3110027H23 gene5659 0.29249 1.17 up Mm.4580 Slc4a2 100020_at J04036 solute carrier family 4 (anion exchanger), member 25660 0.29255 1.27 down Mm.15781 Usf2 103013_at X77602 upstream transcription factor 25661 0.29262 3.41 up Mm.1529 Mylpc 93050_at M91602 myosin light chain, phosphorylatable, cardiac ventricles5662 0.29262 1.30 down Mm.154591 Luc7l 95004_at AA920504 Luc7 homolog (S. cerevisiae)-like5663 0.29274 1.60 up Mm.26934 2200008F12Rik 160221_at AA709879 RIKEN cDNA 2200008F12 gene5664 0.29280 1.58 up Mm.18589 2810406K24Rik 103374_at AI173521 RIKEN cDNA 2810406K24 gene5665 0.29281 1.60 down Mm.3241 AA409897 161280_r_at AV292400 expressed sequence AA4098975666 0.29289 1.76 up Mm.200079 AI504772 99925_f_at AI835567 expressed sequence AI5047725667 0.29305 1.92 up Mm.4766 Vmp 162166_f_at AV360742 vesicular membrain protein p245668 0.29330 1.50 up Mm.129025 C79168 93609_at AA797709 expressed sequence C791685669 0.29345 1.94 up Mm.214851 Atoh7 101811_at AF071223 atonal homolog 7 (Drosophila)5670 0.29350 1.17 up Mm.28355 Mm.28355 104250_at AW121353 ESTsPage 63 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description5671 0.29362 1.50 up Mm.21428 2410091N08Rik 103912_at AW046563 RIKEN cDNA 2410091N08 gene5672 0.29370 1.55 down Mm.2159 Bnip3 93836_at AF041054 BCL2/adenovirus E1B 19 kDa-interacting protein 1, NIP35673 0.29371 1.40 up Mm.20304 Bat2 93900_at AW050268 HLA-B associated transcript 25674 0.29375 1.77 up Mm.12867 Erabp 99236_at U68546 epididymal retinoic acid binding protein5675 0.29381 1.26 down Mm.3629 Tcfap2c 92275_at X94694 transcription factor AP-2, gamma5676 0.29387 1.39 up Mm.197231 Mm.197231 100775_at C81070 ESTs5677 0.29395 1.32 up Mm.194 Flt3 95296_r_at M64689 FMS-like tyrosine kinase 35678 0.29397 1.35 down Mm.29475 2810052M02Rik 95151_at AW061307 RIKEN cDNA 2810052M02 gene5679 0.29400 1.28 down Mm.28908 Adam9 96738_at U41765 a disintegrin and metalloproteinase domain 9 (meltrin gamma)5680 0.29403 1.21 up Mm.2376 Nr2f6 104554_at L25674 nuclear receptor subfamily 2, group F, member 65681 0.29413 1.68 up Mm.57111 Lmx1b 101775_at AF078166 LIM homeobox transcription factor 1 beta5682 0.29421 1.89 up Mm.1971 Calr 93523_at M92988 calreticulin5683 0.29438 5.42 up Mm.735 Fbn1 101090_at L29454 fibrillin 15684 0.29438 1.39 up Mm.12886 Scrg1 94181_at AJ223206 scrapie responsive gene 15685 0.29447 2.28 up Mm.10600 Glud 162364_f_at AV231463 glutamate dehydrogenase5686 0.29451 1.80 up Mm.1373 Ppara 102668_at X57638 peroxisome proliferator activated receptor alpha5687 0.29473 1.21 down Mm.56895 D17H6S56E-3 99652_at AF109905 DNA segment, Chr 17, human D6S56E 35688 0.29498 1.46 down Mm.14239 Tpst2 92868_at AF049890 protein-tyrosine sulfotransferase 25689 0.29504 1.31 down Mm.3308 Ywhah 97536_at AW046650 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,5690 0.29506 1.23 up Mm.1912 Cdkn2c 160638_at U19596 cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)5691 0.29510 1.28 down Mm.18705 Vps4b 93337_at U10119 vacuolar protein sorting 4b (yeast)5692 0.29512 1.22 up Mm.180587 5730406O18Rik 160942_at AI843876 RIKEN cDNA 5730406O18 gene5693 0.29538 1.62 up Mm.21049 Loxl 103850_at U79144 lysyl oxidase-like5694 0.29542 1.46 up Mm.32505 Mm.32505 94109_at AI850113 Mus musculus, Similar to zinc finger protein 281, clone MGC:7737 IMAGE:345695 0.29546 1.43 down Mm.3973 Stx8 99063_at AF036716 syntaxin 85696 0.29557 1.30 down Mm.21819 3100004P22Rik 94011_at AI845182 RIKEN cDNA 3100004P22 gene5697 0.29563 1.65 up Mm.4813 Arnt2 92910_at D63644 aryl hydrocarbon receptor nuclear translocator 25698 0.29569 1.91 up Mm.4376 Chi3l1 99952_at X93035 chitinase 3-like 15699 0.29571 1.86 up Mm.57142 Fpr-rs2 101800_at AF071180 formyl peptide receptor, related sequence 25700 0.29573 1.43 up Mm.2179 Azi2 94006_at AB007141 5-azacytidine induced gene 25701 0.29583 1.28 up Mm.21583 AI462438 160672_at AI462438 expressed sequence AI4624385702 0.29585 1.20 up Mm.140 Png 160078_at X97490 phospholipase c neighboring5703 0.29587 1.75 up Mm.21231 2810430O08Rik 103314_at AW046158 RIKEN cDNA 2810430O08 gene5704 0.29601 1.31 down Mm.18538 Mm.18538 103369_at AW049142 ESTs5705 0.29615 1.82 down Mm.24162 AV073337 95895_at AA216858 expressed sequence AV0733375706 0.29642 1.42 up Mm.6929 D17Ertd197e 101369_at AI391071 DNA segment, Chr 17, ERATO Doi 197, expressed5707 0.29643 1.51 up Mm.20420 2810426M17Rik 160650_at AI844711 RIKEN cDNA 2810426M17 gene5708 0.29654 2.09 up Mm.57143 Fpr-rs3 101801_at AF071181 formyl peptide receptor, related sequence 35709 0.29661 1.52 up Mm.5780 C79015 101600_at C79015 expressed sequence C790155710 0.29661 1.84 up Mm.176725 Mm.176725 102880_at U85993 Mus musculus clone IMAGE:349147 unknown protein mRNA, partial cds5711 0.29685 1.20 up Mm.3438 Lmna 98060_at D49733 lamin A5712 0.29697 1.36 up Mm.14860 Anxa1 93037_i_at M69260 annexin A15713 0.29713 1.42 up Mm.1395 Slpi 162333_r_at AV093322 secretory leukocyte protease inhibitor5714 0.29732 1.54 up Mm.2115 Hnrpu 93761_at AF073992 heterogeneous nuclear ribonucleoprotein U5715 0.29743 1.87 up Mm.29064 1300006E06Rik 94540_at AI595772 RIKEN cDNA 1300006E06 gene5716 0.29746 1.58 up Mm.4708 Syk 162363_at AV230910 spleen tyrosine kinase5717 0.29754 1.21 up Mm.27424 2410195B05Rik 96677_at AI849566 RIKEN cDNA 2410195B05 gene5718 0.29763 1.47 up Mm.25544 Mre11a 94376_s_at U60318 meiotic recombination 11 homolog A (S. cerevisiae)5719 0.29779 1.25 down Mm.5031 Gba 100488_at M24119 acid beta glucosidase5720 0.29786 3.40 up Mm.12940 Calmbp1 102632_at AF062378 calmodulin binding protein 15721 0.29789 1.18 up Mm.183073 Immt 162006_r_at AV334115 inner membrane protein, mitochondrial5722 0.29796 2.39 up Mm.1786 Aprt 161330_r_at AV110009 adenine phosphoribosyl transferase5723 0.29800 1.35 up Mm.10708 Top3a 94124_at AB006074 topoisomerase (DNA) 3 alpha5724 0.29801 2.08 up Mm.22830 Cryba1 104518_at AJ239052 crystallin, beta A15725 0.29801 1.39 up Mm.7196 6330407G04Rik 161613_at AV351002 RIKEN cDNA 6330407G04 gene5726 0.29812 2.26 down Mm.20467 Ntrk3 95334_at AF035400 neurotrophic tyrosine kinase, receptor, type 35727 0.29815 1.27 up Mm.25941 2700094L05Rik 94409_at AI843302 RIKEN cDNA 2700094L05 gene5728 0.29816 2.01 down Mm.211738 Mm.211738 102744_at X00697 Mouse T-cell receptor active gamma-chain mRNA from CTL-DFL12 cell line,5729 0.29824 1.48 up Mm.29428 Matn4 96835_at AJ010984 matrilin 45730 0.29828 1.47 up Mm.36292 Ubh1 160946_at AF022792 ubiquitin hydrolyzing enzyme 15731 0.29833 1.70 up Mm.3280 Twist 98028_at M63649 twist gene homolog, (Drosophila)5732 0.29841 1.33 up Mm.3381 Rps8 100732_at X73829 ribosomal protein S85733 0.29857 1.60 down Mm.148877 Recc1 98336_s_at M88489 replication factor C, 140 kDa5734 0.29859 1.43 up Mm.27923 AU042359 160762_at AI846185 expressed sequence AU0423595735 0.29861 1.40 up Mm.24033 D10Wsu102e 160707_at AI854081 DNA segment, Chr 10, Wayne State University 102, expressed5736 0.29869 1.58 down Mm.5061 Arf2 100518_at D87899 ADP-ribosylation factor 25737 0.29887 2.00 up Mm.213026 Bglap-rs1 162296_at AV380924 bone gamma-carboxyglutamate protein, related sequence 15738 0.29892 1.52 down Mm.24621 Crtr1-pending 103761_at AA734817 Tcfcp2-related transcriptional repressor 15739 0.29895 1.30 up Mm.29846 R74996 160819_at AW121600 expressed sequence R749965740 0.29906 1.88 up Mm.27955 Wbscr1 97278_at AI841273 Williams-Beuren syndrome chromosome region 1 homolog (human)5741 0.29922 1.33 down Mm.27695 AA409446 97205_at AI848056 expressed sequence AA4094465742 0.29927 1.57 up Mm.166658 5530400H20Rik 92672_at AW048640 RIKEN cDNA 5530400H20 gene5743 0.29956 1.18 down Mm.41511 1700023M09Rik 94249_at AW226968 RIKEN cDNA 1700023M09 gene5744 0.29959 1.41 down Mm.18344 Psmc3ip 102970_at AB000121 proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protei5745 0.29991 1.63 up Mm.155714 Myh7 161547_f_at AV243986 myosin, heavy polypeptide 7, cardiac muscle, beta5746 0.29993 3.30 up Mm.10809 Fcgr2b 102337_s_at M31312 Fc receptor, IgG, low affinity IIb5747 0.30043 1.43 up Mm.22214 2610008F03Rik 94211_at AA959180 RIKEN cDNA 2610008F03 gene5748 0.30054 1.62 up Mm.23847 Lrp2 103377_at AW259788 low density lipoprotein receptor-related protein 25749 0.30060 1.63 up Mm.86922 Ror2 93724_at AI596034 receptor tyrosine kinase-like orphan receptor 25750 0.30069 1.68 up Mm.27272 AI043088 96639_at W29424 expressed sequence AI0430885751 0.30075 1.67 up Mm.4651 Kifap3 161604_r_at AV308714 kinesin-associated protein 35752 0.30081 1.49 up Mm.27995 Gpr97 104227_at AI504074 G protein-coupled receptor 975753 0.30081 1.67 up Mm.56964 Wnt7a 101316_at M89801 wingless-related MMTV integration site 7A5754 0.30086 1.93 up Mm.40277 Ptprz 92379_f_at AJ133130 protein tyrosine phosphatase, receptor type, Z5755 0.30098 7.41 up Mm.2271 Scya9 104388_at U49513 small inducible cytokine A95756 0.30108 1.32 down Mm.1466 Idb2 93013_at AF077861 inhibitor of DNA binding 25757 0.30113 1.41 up Mm.10689 Punc 94118_r_at AF026465 putative neuronal cell adhesion molecule5758 0.30133 1.60 up Mm.57127 Ifna1 101788_f_at X01974 interferon alpha family, gene 15759 0.30141 1.87 down Mm.157075 2510004L20Rik 104551_at AW124083 RIKEN cDNA 2510004L20 gene5760 0.30149 1.29 down Mm.567 D16Bwg1547e 100895_at AW049497 DNA segment, Chr 16, Brigham & Women's Genetics 1547 expressedPage 64 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description5761 0.30150 1.80 up Mm.3057 Reln 96591_at U24703 reelin5762 0.30151 2.82 down Mm.4775 Sim2 92896_s_at U40576 single-minded 25763 0.30152 1.35 up Mm.44219 2310005B10Rik 160492_at AI648005 RIKEN cDNA 2310005B10 gene5764 0.30160 1.60 up Mm.4802 Hesx1 98804_at U40720 homeo box gene expressed in ES cells5765 0.30185 1.30 up 103432_at AW1226775766 0.30197 1.57 up Mm.42146 Tlr6 98304_at AB020808 toll-like receptor 65767 0.30203 1.28 up Mm.1183 1300004C08Rik 102279_at AW046479 RIKEN cDNA 1300004C08 gene5768 0.30211 1.65 up Mm.2152 2600017A12Rik 161691_at AV227892 RIKEN cDNA 2600017A12 gene5769 0.30212 1.36 down Mm.31787 AI957324 104661_at AF031164 expressed sequence AI9573245770 0.30214 1.29 up Mm.38426 Islr 99010_at AB024538 immunoglobulin superfamily containing leucine-rich repeat5771 0.30218 1.24 up Mm.200104 AI841843 96226_at AI841843 expressed sequence AI8418435772 0.30219 2.13 up Mm.2377 Ednrb 103550_at U32329 endothelin receptor type B5773 0.30219 1.41 up Mm.30487 Slc27a4 97957_at AF072759 solute carrier family 27 (fatty acid transporter), member 45774 0.30219 1.47 up Mm.28502 2410141K03Rik 96189_at AW046184 RIKEN cDNA 2410141K03 gene5775 0.30220 1.35 up Mm.34421 H2-Q7 99379_f_at M27034 histocompatibility 2, Q region locus 75776 0.30227 1.26 down Mm.28335 1500041L05Rik 104247_at AI846291 RIKEN cDNA 1500041L05 gene5777 0.30233 2.52 up Mm.21642 Spic 103454_at AA182189 Spi-C transcription factor (Spi-1/PU.1 related)5778 0.30238 1.84 up Mm.4762 Kif1a 92890_at D29951 kinesin heavy chain member 1A5779 0.30258 1.23 up Mm.796 Sacm1l 160930_at AW123983 SAC1 (supressor of actin mutations 1, homolog)-like (S. cerevisiae)5780 0.30269 1.82 up Mm.22430 Ask-pending 160687_r_at AJ003132 activator of S phase kinase5781 0.30272 1.35 up Mm.3689 Cd37 98980_at U18372 CD37 antigen5782 0.30287 1.94 up Mm.3059 Nsmaf 161700_i_at AV235556 neutral sphingomyelinase (N-SMase) activation associated factor5783 0.30304 1.17 down Mm.22183 AI785303 104148_at AA939571 expressed sequence AI7853035784 0.30307 2.19 up Mm.30024 Emp1 97426_at X98471 epithelial membrane protein 15785 0.30317 1.99 up Mm.8064 Cdh9 94640_at U69136 cadherin 95786 0.30320 2.05 up Mm.25793 Hgn-pending 94401_s_at AA986548 hemogen5787 0.30331 1.63 up Mm.5120 Galc 93131_at D38557 galactosylceramidase5788 0.30338 1.47 up Mm.104747 Igk-V28 101332_at AB001737 immunoglobulin kappa chain variable 28 (V28)5789 0.30340 1.52 down Mm.29541 1110004G16Rik 95656_i_at AW125164 RIKEN cDNA 1110004G16 gene5790 0.30340 1.16 down Mm.193451 Il11ra2 93874_s_at U69491 interleukin 11 receptor, alpha chain 25791 0.30341 1.19 up Mm.33575 Gna-rs1 161304_r_at AV350102 guanine nucleotide binding protein, related sequence 15792 0.30345 1.68 up Mm.89924 Mrpplf3 93929_s_at X16009 mitogen regulated protein, proliferin 35793 0.30347 1.36 down Mm.1773 Sh3d2b 93275_at U58885 SH3 domain protein 2B5794 0.30349 1.39 up Mm.42254 Phka1 92519_at X74616 phosphorylase kinase alpha 15795 0.30350 1.61 up Mm.18553 Mug2 102973_f_at M65238 murinoglobulin 25796 0.30360 1.53 up Mm.206536 Sdc3 98847_at U52826 syndecan 35797 0.30365 1.29 down Mm.1863 Tbca 93333_at U05333 tubulin cofactor a5798 0.30366 1.60 up Mm.25678 Mid2 103967_at AI551105 midline 25799 0.30367 1.65 up Mm.29204 Tactile-pending 104430_at AA981582 T cell activation, increased late expression5800 0.30372 1.46 up Mm.41929 Mm.41929 92451_at AI842588 ESTs, Moderately similar to AF121775 1 nasopharyngeal carcinoma suscep5801 0.30406 1.41 down Mm.196006 Mlh1 104577_at AA920621 mutL homolog 1 (E. coli)5802 0.30409 1.16 up Mm.155000 Clptm1 95713_at D67067 cleft lip and palate associated transmembrane protein 15803 0.30426 1.16 down Mm.46354 Acp5 98859_at M99054 acid phosphatase 5, tartrate resistant5804 0.30428 1.43 up Mm.8055 Tacr1 94635_at X62934 tachykinin receptor 15805 0.30450 1.24 down Mm.29728 Glrx1 95722_at AB013137 glutaredoxin 1 (thioltransferase)5806 0.30457 2.05 up Mm.25090 C80060 96484_at C80857 expressed sequence C800605807 0.30459 1.60 up Mm.3075 Dnajb3 97481_r_at U95607 DnaJ (Hsp40) homolog, subfamily B, member 35808 0.30464 1.85 up Mm.667 Gstm5 161722_f_at AV263874 glutathione S-transferase, mu 55809 0.30500 1.37 down Mm.4268 Rab7 95785_s_at Y13361 RAB7, member RAS oncogene family5810 0.30509 1.87 up Mm.23804 4933426K21Rik 104556_at AI847766 RIKEN cDNA 4933426K21 gene5811 0.30511 1.72 down Mm.1214 Hoxd4 102380_s_at U77364 homeo box D45812 0.30518 1.24 up 93225_s_at AB0102665813 0.30523 1.22 down Mm.24635 2310075G12Rik 95449_at AW049793 RIKEN cDNA 2310075G12 gene5814 0.30524 1.85 up Mm.14313 Tek 102720_at X71426 endothelial-specific receptor tyrosine kinase5815 0.30536 1.24 up 99055_at X940005816 0.30543 1.29 down Mm.28622 AL022641 98918_at AI841920 expressed sequence AL0226415817 0.30543 1.21 down Mm.28148 Cbx3 160272_at AI849356 chromobox homolog 3 (Drosophila HP1 gamma)5818 0.30546 2.21 up Mm.3782 Ott 92306_at X96603 ovary <strong>test</strong>is transcribed5819 0.30546 1.55 up Mm.200691 AI853843 94053_at AI853843 expressed sequence AI8538435820 0.30551 1.62 up Mm.2399 Lama4 161793_at AV365098 laminin, alpha 45821 0.30562 1.78 up Mm.2760 Zipro1 162492_at AV142478 zinc finger proliferation 15822 0.30570 1.76 up Mm.41401 AA589632 97748_at AI854327 expressed sequence AA5896325823 0.30571 1.55 up Mm.24338 BB101783 104631_g_at AA914114 expressed sequence BB1017835824 0.30573 1.25 down Mm.74084 D9Wsu149e 101097_at AW121176 DNA segment, Chr 9, Wayne State University 149, expressed5825 0.30585 1.81 up Mm.2477 Prph1 104751_at X15475 peripherin 15826 0.30585 1.21 down Mm.27839 4930455J02Rik 97241_at AI787713 RIKEN cDNA 4930455J02 gene5827 0.30590 1.34 down Mm.22986 Gltp-pending 104524_at AI842825 glycolipid transfer protein5828 0.30598 1.29 up Mm.5378 Fgfrp 100884_at U04204 fibroblast growth factor regulated protein5829 0.30622 1.54 up Mm.252 Nqo1 94350_f_at U12961 NAD(P)H dehydrogenase, quinone 15830 0.30625 1.15 down Mm.1109 Wbp1 92619_at U40825 WW domain binding protein 15831 0.30638 1.46 up Mm.26930 Mm.26930 104018_at AW060787 ESTs, Moderately similar to LPH RAT LACTASE-PHLORIZIN HYDROLASE5832 0.30656 1.56 down Mm.4683 Fancc 160895_at L08266 Fanconi anemia, complementation group C5833 0.30660 1.37 down Mm.104085 Mm.104085 92900_at AU040769 ESTs5834 0.30667 1.90 up Mm.9986 Mpz 93715_at M62860 myelin protein zero5835 0.30684 1.72 up Mm.16925 AI848392 160093_r_at AV150572 expressed sequence AI8483925836 0.30687 1.73 up Mm.219615 Mm.219615 101820_at X70920 Mus musculus, Similar to lymphocyte antigen 6 complex, locus F, clone MGC5837 0.30691 1.65 down Mm.2921 Prkcq 161853_f_at AV336804 protein kinase C, theta5838 0.30691 1.71 up Mm.22970 Nxph3 98363_at U56650 neurexophilin 35839 0.30692 1.52 up Mm.4355 Uchrp 161999_at AV330895 ubiquintin c-terminal hydrolase related polypeptide5840 0.30694 1.75 up Mm.28806 Ubce7ip3-pending 161152_r_at AV230260 ubiquitin conjugating enzyme 7 interacting protein 35841 0.30699 1.42 up Mm.30023 AL024256 96845_at AI849577 expressed sequence AL0242565842 0.30700 1.19 down Mm.19055 1110068E11Rik 93490_at AI841771 RIKEN cDNA 1110068E11 gene5843 0.30702 1.79 up Mm.25024 Mm.25024 95979_at C79305 ESTs, Moderately similar to S12207 hypothetical protein [M.musculus]5844 0.30715 1.57 up Mm.28286 4931406I20Rik 161937_r_at AV332798 RIKEN cDNA 4931406I20 gene5845 0.30742 2.21 up Mm.35087 AA673488 97133_at AA673488 expressed sequence AA6734885846 0.30744 1.86 down Mm.38868 1300009F09Rik 161472_r_at AV019864 RIKEN cDNA 1300009F09 gene5847 0.30760 1.93 down Mm.212716 Mm.212716 97574_f_at AF036736 Mus musculus mRNA for immunoglobulin heavy chain, mAb 6675848 0.30767 1.33 down Mm.27117 5830482G23Rik 94951_at AI853260 RIKEN cDNA 5830482G23 gene5849 0.30769 1.64 down Mm.3918 Abca4 97730_at AF000149 ATP-binding cassette, sub-family A (ABC1), member 45850 0.30771 1.42 up Mm.44100 Mm.44100 92654_at AI836802 ESTs, Weakly similar to RPA1 MOUSE DNA-DIRECTED RNA POLYMERASPage 65 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description5851 0.30772 2.26 up Mm.194940 AI194696 94993_f_at M29010 expressed sequence AI1946965852 0.30779 1.39 up Mm.4763 Mdfi 100432_f_at U57820 MyoD family inhibitor5853 0.30781 2.07 up 103004_r_at U576115854 0.30785 1.73 up Mm.22514 0610008F14Rik 161331_r_at AV114328 RIKEN cDNA 0610008F14 gene5855 0.30785 1.26 down Mm.4962 Tde1 100151_at L29441 tumor differentially expressed 15856 0.30789 1.48 up Mm.34405 Casp3 98436_s_at U54803 caspase 3, apoptosis related cysteine protease5857 0.30794 1.55 up Mm.117943 Mm.117943 96539_at AW212071 ESTs5858 0.30795 1.92 up Mm.6225 Stx1a 100933_at D45208 syntaxin 1A (brain)5859 0.30810 3.04 up Mm.196770 Bcl2a1b 102914_s_at U23778 B-cell leukemia/lymphoma 2 related protein A1b5860 0.30825 1.41 up Mm.56915 Csf3r 95807_at U05894 colony stimulating factor 3 receptor (granulocyte)5861 0.30858 1.32 up Mm.205855 D13Wsu123e 94452_g_at AI787627 DNA segment, Chr 13, Wayne State University 123, expressed5862 0.30863 1.54 up Mm.28147 0610011M24Rik 96134_at AA755260 RIKEN cDNA 0610011M24 gene5863 0.30867 1.62 up Mm.12654 AU017694 160598_at AW211627 expressed sequence AU0176945864 0.30871 1.16 down Mm.200447 AI256223 104557_at AI847097 expressed sequence AI2562235865 0.30876 1.53 up Mm.2072 2210417J23Rik 103256_at AI509811 RIKEN cDNA 2210417J23 gene5866 0.30878 2.80 up Mm.142354 1190006K01Rik 104723_at AW049986 RIKEN cDNA 1190006K01 gene5867 0.30883 1.29 up Mm.219464 Cdk2 94412_at AJ223733 cyclin-dependent kinase 25868 0.30884 1.17 down Mm.8403 Acox1 101515_at AF006688 acyl-Coenzyme A oxidase 1, palmitoyl5869 0.30888 1.49 down Mm.7261 D14Ertd231e 160924_at AI839362 DNA segment, Chr 14, ERATO Doi 231, expressed5870 0.30910 1.85 up Mm.2422 Pah 95407_at X51942 phenylalanine hydroxylase5871 0.30920 1.31 down Mm.27829 AW558785 95577_at AW049625 expressed sequence AW5587855872 0.30927 1.69 up Mm.29030 Sh3d5 161946_r_at AV359416 SH3 domain protein 55873 0.30929 1.47 down Mm.24485 AA408298 161104_at AI846811 expressed sequence AA4082985874 0.30930 1.26 up Mm.29135 Snrpd2 95049_at AI837853 small nuclear ribonucleoprotein D25875 0.30932 1.81 up Mm.28675 4833427B12Rik 98932_at AI854638 RIKEN cDNA 4833427B12 gene5876 0.30936 1.93 up Mm.4417 Zfp101 99963_at U07861 zinc finger protein 1015877 0.30942 1.30 down Mm.196479 1810030E20Rik 98927_at AI851048 RIKEN cDNA 1810030E20 gene5878 0.30984 1.72 up Mm.4527 Cd3d 92683_at X02339 CD3 antigen, delta polypeptide5879 0.30987 1.56 up Mm.2044 Serpinf1 162429_r_at AV293879 serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigme5880 0.30989 1.83 up Mm.21108 1110061B18Rik 162294_f_at AV377907 RIKEN cDNA 1110061B18 gene5881 0.30999 1.68 down 101174_at Z482385882 0.31019 1.70 up Mm.23690 4930517K11Rik 104544_at AA675604 RIKEN cDNA 4930517K11 gene5883 0.31024 1.79 up Mm.103866 C80425 92520_at C80425 expressed sequence C804255884 0.31033 1.92 down Mm.88406 Itpr2 96420_at M90087 inositol 1,4,5-triphosphate receptor 25885 0.31060 1.81 up Mm.27630 Ars-pending 96537_at AJ132356 Ars component B5886 0.31066 1.21 down Mm.3035 3110006P09Rik 97463_g_at AI847584 RIKEN cDNA 3110006P09 gene5887 0.31072 1.59 up Mm.542 Rbm4 100546_at U89506 RNA binding motif protein 45888 0.31075 2.71 up Mm.79380 Lhx9 93644_at AJ243852 LIM homeobox protein 95889 0.31076 1.57 up Mm.4863 Cebpb 92925_at M61007 CCAAT/enhancer binding protein (C/EBP), beta5890 0.31080 1.41 up Mm.4077 Mm.4077 162251_f_at AV335015 ESTs5891 0.31093 1.29 up Mm.22537 2610100E10Rik 104346_at AI841914 RIKEN cDNA 2610100E10 gene5892 0.31093 1.56 up Mm.15918 Map3k1 103021_r_at AI317205 mitogen activated protein kinase kinase kinase 15893 0.31095 1.47 up Mm.4606 Bcat1 100026_at U42443 branched chain aminotransferase 1, cytosolic5894 0.31111 1.88 up Mm.150 Fcgr1 101793_at X70980 Fc receptor, IgG, high affinity I5895 0.31118 2.15 up Mm.194940 AI194696 161692_r_at AV228333 expressed sequence AI1946965896 0.31122 1.40 up Mm.117068 Cldn2 93934_at AF072128 claudin 25897 0.31125 1.94 up Mm.6231 V2r2 101630_f_at AF011412 vomeronasal 2, receptor, 25898 0.31128 1.47 up Mm.30090 Slc22a6 97431_at U52842 solute carrier family 22 (organic anion transporter), member 65899 0.31139 1.77 up Mm.9431 Prss12 93953_at D89871 protease, serine, 12 neurotrypsin, (motopsin)5900 0.31142 1.64 up Mm.2209 Cd4 103480_at M17080 CD4 antigen5901 0.31157 1.44 up Mm.1803 Tank 103328_at U59864 TRAF family member-associated Nf-kappa B activator5902 0.31172 2.04 up Mm.197696 Pcdha5 97756_s_at AB008181 protocadherin alpha 55903 0.31201 1.93 up Mm.35059 Arhgap5 92247_at U67160 rho GTPase activating protein 55904 0.31206 1.55 down Mm.3907 Slc6a4 161695_f_at AV230927 solute carrier family 6 (neurotransmitter transporter, serotonin), member 45905 0.31211 1.92 up Mm.20855 Il13ra2 95344_at U65747 interleukin 13 receptor, alpha 25906 0.31215 1.18 up Mm.9852 Apg12l 101997_at AI851598 Apg12 autophagy 12-like (S. cerevisiae)5907 0.31217 1.29 up Mm.149203 Mm.149203 96968_at AB024521 Mus musculus mRNA for limitin, complete cds5908 0.31225 1.47 up Mm.368 Psmb4 98556_at AA638816 proteasome (prosome, macropain) subunit, beta type 45909 0.31232 18.19 up Mm.14095 Gzmd 102688_f_at X56990 granzyme D5910 0.31267 1.66 up Mm.1612 F2rl2 94762_at U92972 coagulation factor II (thrombin) receptor-like 25911 0.31267 1.60 down Mm.1364 Npn3 161090_i_at AV374584 neoplastic progression 35912 0.31271 1.68 up Mm.200518 Slc6a6 94405_at AI042802 solute carrier family 6 (neurotransmitter transporter, taurine), member 65913 0.31281 2.38 up Mm.89727 Bop 101904_at U76372 CD8beta opposite strand5914 0.31282 1.54 up Mm.3403 Fgf6 97121_at M92416 fibroblast growth factor 65915 0.31302 1.31 up Mm.27509 1110038O14Rik 96691_at AI845542 RIKEN cDNA 1110038O14 gene5916 0.31305 1.36 up Mm.203962 Bat3 101854_r_at AI844178 HLA-B-associated transcript 35917 0.31319 1.59 up Mm.215214 AW047450 160597_at AW047450 expressed sequence AW0474505918 0.31320 2.19 up Mm.18353 Dpagt2 161420_r_at AV324170 dolichyl-phosphate alpha-N-acetylglucosaminephosphotransferase 25919 0.31329 1.97 up Mm.146 Zfp127 102740_at U19106 zinc finger protein 1275920 0.31337 1.52 down Mm.18133 Cdkl2 160623_at AI847045 cyclin-dependent kinase-like 2 (CDC2-related kinase)5921 0.31338 1.61 up Mm.25081 C80638 96481_at AV251613 expressed sequence C806385922 0.31341 1.81 up Mm.4806 Epha7 92905_at X79082 Eph receptor A75923 0.31366 1.51 up Mm.1994 Taf6 103591_at D49439 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor5924 0.31375 2.12 up Mm.1840 Cyp4b1 162044_f_at AV376161 cytochrome P450, subfamily IV B, polypeptide 15925 0.31380 1.23 up Mm.2338 Glns 161826_r_at AV381947 glutamine synthetase5926 0.31383 1.29 up Mm.22929 C77080 161696_f_at AV232292 expressed sequence C770805927 0.31387 1.27 down Mm.27406 Mm.27406 96676_at AW121875 ESTs5928 0.31393 1.41 up Mm.22690 Nr1h3 104381_at AF085745 nuclear receptor subfamily 1, group H, member 35929 0.31395 2.20 up Mm.24179 AW061228 161574_r_at AV356516 expressed sequence AW0612285930 0.31407 1.26 up Mm.18803 Timm22 93348_at AA760359 translocase of inner mitochondrial membrane 22 homolog (yeast)5931 0.31408 1.71 up Mm.1196 AW536703 93916_at U50384 expressed sequence AW5367035932 0.31411 1.08 up Mm.154136 2500003M10Rik 93599_at AI841260 RIKEN cDNA 2500003M10 gene5933 0.31412 1.46 up Mm.24280 4921514G19Rik 161870_at AV359471 RIKEN cDNA 4921514G19 gene5934 0.31420 1.19 down Mm.3479 Atp6f 98104_at AI842889 ATPase, H+ transporting, lysosomal (vacuolar proton pump)5935 0.31422 1.40 up Mm.67998 Tcerg1 101008_at AB023485 transcription elongation regulator 1 (CA150)5936 0.31443 1.35 down Mm.5601 D8Ertd91e 93195_at AI957146 DNA segment, Chr 8, ERATO Doi 91, expressed5937 0.31457 1.40 down Mm.13000 Hal 92833_at L07645 histidine ammonia lyase5938 0.31463 1.50 up Mm.18810 2900028O21Rik 93350_f_at AW209414 RIKEN cDNA 2900028O21 gene5939 0.31469 1.40 up Mm.27920 Mm.27920 104219_f_at AI447483 ESTs, Moderately similar to YO11 MOUSE HYPOTHETICAL PROTEIN ORF5940 0.31473 1.30 down Mm.45217 Mm.45217 92338_f_at AI957030 Mus musculus, clone MGC:12134 IMAGE:3710576, mRNA, complete cdsPage 66 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description5941 0.31483 2.44 up Mm.10685 Npy5r 94115_at AF049329 neuropeptide Y receptor Y55942 0.31510 1.28 down Mm.20325 Naga 103637_at AJ223966 N-acetyl galactosaminidase, alpha5943 0.31519 2.03 down Mm.200561 C79663 162380_r_at AV245426 expressed sequence C796635944 0.31558 1.32 down Mm.7335 Cnbp 101088_f_at U20326 cellular nucleic acid binding protein5945 0.31594 1.50 up Mm.87779 Klk1 100681_f_at V00829 kallikrein 15946 0.31600 2.71 up Mm.202142 Defcr 92812_f_at U02995 defensin related cryptdin peptide5947 0.31607 1.31 up Mm.148155 Mod1 101082_at J02652 malic enzyme, supernatant5948 0.31610 1.38 down Mm.28060 2310058J06Rik 95627_at AW046038 RIKEN cDNA 2310058J06 gene5949 0.31616 1.56 up Mm.182227 4931406C07Rik 96091_at AW060190 RIKEN cDNA 4931406C07 gene5950 0.31616 1.40 up Mm.21587 Slc9a3r2 104064_at AW045908 solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 25951 0.31620 1.54 up Mm.29203 Mm.29203 96804_at AI854811 Mus musculus, clone MGC:7905 IMAGE:3583039, mRNA, complete cds5952 0.31627 1.59 up Mm.182309 Prodh2 103452_at AA675075 proline dehydrogenase (oxidase) 25953 0.31646 1.48 up Mm.25547 0610037B21Rik 94377_at AI854793 RIKEN cDNA 0610037B21 gene5954 0.31653 1.23 up Mm.27853 D7Wsu180e 162153_i_at AV333522 DNA segment, Chr 7, Wayne State University 180, expressed5955 0.31662 1.20 up Mm.26792 2310056P07Rik 160218_at AW123751 RIKEN cDNA 2310056P07 gene5956 0.31662 2.56 up Mm.27805 AI266885 104213_at AI266885 expressed sequence AI2668855957 0.31664 1.23 up Mm.6065 Impdh2 100578_at M33934 inosine 5'-phosphate dehydrogenase 25958 0.31671 1.78 up Mm.4352 Col15a1 99637_at AF011450 procollagen, type XV5959 0.31675 1.23 up Mm.29829 AI326010 96262_at AI836812 expressed sequence AI3260105960 0.31680 2.18 up Mm.20206 Aqp2 103612_at AI661431 aquaporin 25961 0.31681 1.76 down Mm.24573 Gab1 93902_at AJ250669 growth factor receptor bound protein 2-associated protein 15962 0.31692 1.71 up Mm.24971 C77815 95864_at C77815 expressed sequence C778155963 0.31693 1.46 up Mm.6822 Edr1 100992_at U63386 early development regulator 1 (homolog of polyhomeotic 1)5964 0.31709 1.23 down Mm.7524 Dag1 101109_at U43512 dystroglycan 15965 0.31715 1.71 up Mm.27592 Ncoa6 95351_at AA414339 nuclear receptor coactivator 65966 0.31727 1.35 up Mm.29670 C79673 160815_at AA709534 expressed sequence C796735967 0.31753 1.78 up Mm.28780 Plxnb2 94447_at AA726837 plexin B25968 0.31757 1.56 up Mm.6609 Serpind1 100966_at U07425 serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member5969 0.31782 1.53 down Mm.18783 2610019A05Rik 103405_at AI845617 RIKEN cDNA 2610019A05 gene5970 0.31783 2.50 up Mm.30374 Crygc 93457_at Z22573 crystallin, gamma C5971 0.31785 1.38 down Mm.23894 Dhodh 103683_at AF029667 dihydroorotate dehydrogenase5972 0.31788 1.25 down Mm.18494 Map2k3 93314_g_at X93150 mitogen activated protein kinase kinase 35973 0.31790 1.56 up Mm.2209 Cd4 103993_at AC002397 CD4 antigen5974 0.31800 1.55 up Mm.4214 Pla2g10 161034_at AA607557 phospholipase A2, group X5975 0.31801 1.60 up Mm.88823 Or10 96983_at AB030893 gene for odorant receptor MOR105976 0.31808 5.02 up Mm.172 Lox 160095_at D10837 lysyl oxidase5977 0.31808 1.99 up Mm.4196 AA511261 101117_at AA511261 expressed sequence AA5112615978 0.31813 1.97 up Mm.7381 Hig1-pending 161976_r_at AV372261 hypoxia induced gene 15979 0.31832 1.19 up Mm.141083 Mm.141083 100988_at AA796690 ESTs5980 0.31838 1.18 up Mm.116 H2-Oa 99953_at AF100956 histocompatibility 2, O region alpha locus5981 0.31848 1.56 up Mm.3485 Hpxn 161827_f_at AV105307 hemopexin5982 0.31858 1.50 up Mm.4866 Etv1 92927_at L10426 ets variant gene 15983 0.31862 1.51 up Mm.8008 Crx 99900_at U77615 cone-rod homeobox containing gene5984 0.31866 1.18 down Mm.65264 1500010B24Rik 93358_at AI836451 RIKEN cDNA 1500010B24 gene5985 0.31868 1.58 up Mm.28261 Ncoa4 161381_r_at AV246755 nuclear receptor coactivator 45986 0.31869 1.45 up Mm.24570 AA589481 161581_r_at AV316101 expressed sequence AA5894815987 0.31870 1.52 up Mm.22182 Wnt11 103490_at X70800 wingless-related MMTV integration site 115988 0.31887 1.90 up Mm.213064 Mm.213064 161679_r_at AV174039 Mus musculus, clone MGC:19411 IMAGE:3483521, mRNA, complete cds5989 0.31892 1.49 up Mm.28800 Mm.28800 161356_at AV207158 ESTs5990 0.31901 1.66 up Mm.24053 AA986766 103703_f_at AI647632 expressed sequence AA9867665991 0.31902 1.72 up Mm.4767 Gast 162472_f_at AV072692 gastrin5992 0.31905 1.45 down Mm.7362 Lmnb2 101414_at X54098 lamin B25993 0.31915 1.66 up Mm.29973 Cyp2c40 96334_f_at AF047727 cytochrome P450, 2c405994 0.31916 1.70 up Mm.193062 Dcpp 93765_at U03711 demilune cell and parotid protein5995 0.31946 1.15 down Mm.15622 B4galt1 103002_at M27923 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 15996 0.31947 1.23 down Mm.4263 Cst3 99586_at U10098 cystatin C5997 0.31948 1.46 up Mm.20908 Shd 103819_at AB018423 src homology 2 domain-containing transforming protein D5998 0.31948 1.53 down Mm.24397 4933436C10Rik 160189_at AI843747 RIKEN cDNA 4933436C10 gene5999 0.31956 1.78 up Mm.1323 Snrpb2 162026_r_at AV366144 U2 small nuclear ribonucleoprotein B6000 0.31958 1.40 up Mm.24880 Mm.24880 161108_r_at W40747 ESTs, Weakly similar to B39898 phospholipase A2 [M.musculus]6001 0.31960 1.44 up Mm.206841 C79747 101906_at AA032310 expressed sequence C797476002 0.31974 1.20 down Mm.23834 Mm.23834 95395_at AI225869 Mus musculus, clone IMAGE:3994696, mRNA, partial cds6003 0.31976 1.33 up Mm.42101 Cyp2c39 98295_at AF047726 cytochrome P450, 2c396004 0.31993 1.39 up Mm.10272 Lrrfip1 92563_at AF045573 leucine rich repeat (in FLII) interacting protein 16005 0.32006 1.31 down Mm.195916 D18Wsu154e 160976_at AA222943 DNA segment, Chr 18, Wayne State University 154, expressed6006 0.32021 2.18 up Mm.4665 Aebp1 100411_at AF053943 AE binding protein 16007 0.32021 1.79 up Mm.368 Psmb4 98558_r_at U65636 proteasome (prosome, macropain) subunit, beta type 46008 0.32022 1.71 up Mm.1818 Mm.1818 94800_at AA185333 ESTs6009 0.32024 1.24 up Mm.34490 2610318I15Rik 98439_at AW049356 RIKEN cDNA 2610318I15 gene6010 0.32024 1.22 down Mm.29049 1190006A08Rik 160322_at AW123666 RIKEN cDNA 1190006A08 gene6011 0.32032 2.06 up Mm.34556 Car14 97365_at AI848032 carbonic anhydrase 146012 0.32041 1.43 up Mm.14297 Nr2f1 102715_at X74134 nuclear receptor subfamily 2, group F, member 16013 0.32042 1.47 up Mm.14798 Rps13 93027_r_at AI836214 ribosomal protein S136014 0.32052 1.25 up Mm.24950 D16Ertd36e 162337_f_at AV101197 DNA segment, Chr 16, ERATO Doi 36, expressed6015 0.32062 1.16 down Mm.6586 AI836376 100621_at AI848825 expressed sequence AI8363766016 0.32072 1.20 down Mm.1838 Vamp8 100345_f_at W65964 vesicle-associated membrane protein 86017 0.32074 1.31 down Mm.5612 C85189 161342_r_at AV136028 expressed sequence C851896018 0.32076 1.35 up Mm.27701 Arhd 95547_at D89821 ras homolog D (RhoD)6019 0.32090 1.45 up Mm.22116 AI507170 104138_at AW125119 expressed sequence AI5071706020 0.32091 1.82 up Mm.114116 GU2 161800_r_at AV369200 nucleolar protein GU26021 0.32125 2.02 up Mm.14104 Kcna6 94719_at M96688 potassium voltage-gated channel, shaker-related, subfamily, member 66022 0.32128 1.37 down Mm.24848 1110020I04Rik 95478_at AW124231 RIKEN cDNA 1110020I04 gene6023 0.32135 1.26 down Mm.3158 Rplp1 94952_at AI152780 ribosomal protein, large, P16024 0.32138 1.24 up Mm.28480 Fkbp3 160416_at U62545 FK506 binding protein 3 (25kD)6025 0.32140 1.73 up Mm.183986 D6Bwg1452e 99779_at N28141 DNA segment, Chr 6, Brigham & Women's Genetics 1452 expressed6026 0.32150 1.38 down Mm.2969 Akap 97367_at U95146 A kinase anchor protein6027 0.32159 1.37 down Mm.4340 Zfp100 99932_at U14556 zinc finger protein 1006028 0.32164 1.25 up Mm.38295 AI846570 97744_at AI847619 expressed sequence AI8465706029 0.32181 1.72 up Mm.195451 Gosr2 94070_at AW125571 golgi SNAP receptor complex member 26030 0.32201 1.40 up Mm.17249 Hebp1 103085_at AB013095 heme binding protein 1Page 67 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description6031 0.32216 2.09 up Mm.154036 Mm.154036 93959_at AA863909 ESTs6032 0.32216 1.90 up Mm.5932 C80360 101608_at C80360 expressed sequence C803606033 0.32224 1.76 down Mm.29090 4021401A16Rik 161880_r_at AV087390 RIKEN cDNA 4021401A16 gene6034 0.32230 1.49 up Mm.2657 En1 96523_at L12703 engrailed 16035 0.32234 1.21 down Mm.25143 Mprs15 95498_at AI836029 mitochondrial ribosomal protein S156036 0.32235 1.93 up Mm.14530 Rab1 92883_at AI853053 RAB1, member RAS oncogene family6037 0.32238 1.86 down Mm.2656 Slc17a1 96078_g_at X77241 solute carrier family 17 vesicular glutamate transporter), member 16038 0.32240 1.24 up Mm.30169 Ehd1 96930_at AI844128 EH-domain containing 16039 0.32245 2.53 up Mm.25088 C80113 96483_at C80828 expressed sequence C801136040 0.32258 1.92 up Mm.57193 Nat3 101825_at X72959 N-acetyltransferase 36041 0.32264 1.26 up Mm.2536 Alk 96506_at D83002 anaplastic lymphoma kinase6042 0.32264 1.11 down Mm.22403 2610020G18Rik 104313_at AI842432 RIKEN cDNA 2610020G18 gene6043 0.32275 1.32 up Mm.181005 Rab10 101933_at AF035646 RAB10, member RAS oncogene family6044 0.32276 1.69 up Mm.4351 Avpr1a 161189_r_at AV240013 arginine vasopressin receptor 1A6045 0.32279 1.59 up Mm.28553 5730589K01Rik 161187_f_at AV247282 RIKEN cDNA 5730589K01 gene6046 0.32281 1.57 down Mm.18036 E2f1 102963_at L21973 E2F transcription factor 16047 0.32283 1.58 up Mm.27467 Arhj 104697_at AW121127 ras homolog gene family, member J6048 0.32284 2.33 up Mm.8062 Zic4 100284_at D78174 zinc finger protein of the cerebellum 46049 0.32294 1.24 up Mm.38786 Mm.38786 96746_at AW124813 Mus musculus, clone IMAGE:3586777, mRNA, partial cds6050 0.32305 1.48 down Mm.17339 Sult1a1 103087_at L02331 sulfotransferase family 1A, phenol-preferring, member 16051 0.32318 1.44 down Mm.43721 Snrpn 102163_at X60388 small nuclear ribonucleoprotein N6052 0.32321 2.00 up Mm.8039 Areg 99915_at L41352 amphiregulin6053 0.32330 1.44 down Mm.182913 Csnk1d 162001_f_at AV333030 casein kinase 1, delta6054 0.32332 2.16 up Mm.5279 D7Bwg0826e 101211_at R74675 DNA segment, Chr 7, Brigham & Women's Genetics 0826 expressed6055 0.32347 1.42 down Mm.8000 Cmkbr8 99895_at AF001277 chemokine (C-C) receptor 86056 0.32358 1.43 up Mm.29615 2610001J05Rik 97346_at AW124115 RIKEN cDNA 2610001J05 gene6057 0.32370 1.95 up Mm.10279 Crap 102048_at AF041847 cardiac responsive adriamycin protein6058 0.32373 1.44 up Mm.74594 Gcl 100281_at AW060252 germ cell-less homolog (Drosophila)6059 0.32375 2.46 up Mm.22708 Serpinh1 94817_at X60676 serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), me6060 0.32377 2.27 up Mm.29358 2700055K07Rik 95108_at AI847955 RIKEN cDNA 2700055K07 gene6061 0.32388 1.63 up Mm.57 Acr 93207_at D00754 preproacrosin6062 0.32389 1.44 down Mm.3410 Six5 97122_at D83146 sine oculis-related homeobox 5 homolog (Drosophila)6063 0.32392 1.31 up Mm.7756 Dnalc4 101480_at AB010031 dynein, axon, light chain 46064 0.32395 1.37 up Mm.27988 D2Ertd52e 104225_at AI645050 DNA segment, Chr 2, ERATO Doi 52, expressed6065 0.32395 1.26 up Mm.56926 0610037M15Rik 99378_f_at M18837 RIKEN cDNA 0610037M15 gene6066 0.32398 1.56 down Mm.8858 Rora 101888_at Y08640 RAR-related orphan receptor alpha6067 0.32408 1.60 up Mm.104747 Igk-V28 97570_at AF044198 immunoglobulin kappa chain variable 28 (V28)6068 0.32408 1.51 up Mm.12842 Vcl 94964_at L18880 vinculin6069 0.32413 1.60 up Mm.182905 Slc12a3 93570_at U61085 solute carrier family 12, member 36070 0.32424 1.41 down Mm.8649 Mox2 101851_at AF029215 antigen identified by monoclonal antibody MRC OX-26071 0.32443 1.95 up Mm.27577 Mm.27577 162290_f_at AV376843 ESTs, Weakly similar to ZF26 MOUSE ZINC FINGER PROTEIN 26 [M.musc6072 0.32447 1.41 up Mm.14483 Birc3 161883_f_at AV367276 baculoviral IAP repeat-containing 36073 0.32452 1.30 up Mm.196584 Map2k2 92543_at AW123542 mitogen activated protein kinase kinase 26074 0.32458 1.92 up Mm.87443 Kpna4 100320_at AF020771 karyopherin (importin) alpha 46075 0.32459 1.96 up Mm.20122 Mm.20122 95306_at AI326966 Mus musculus urotensin II receptor mRNA, complete cds6076 0.32459 1.40 up Mm.38802 D11Moh35 160454_at AW123401 DNA segment, Chr 11, KL Mohlke 356077 0.32491 1.42 up Mm.21344 2010200J04Rik 160666_at AI835436 RIKEN cDNA 2010200J04 gene6078 0.32502 1.20 up Mm.196045 4930467B06Rik 103663_at AI837330 RIKEN cDNA 4930467B06 gene6079 0.32512 1.64 up Mm.12930 Bazf 94189_at AB011665 BcL6-associated zinc finger protein6080 0.32514 1.64 up Mm.56941 Olfr15 102583_at AJ132195 olfactory receptor 156081 0.32523 1.37 up Mm.4756 Lepr 93600_at AJ011565 leptin receptor6082 0.32532 1.21 up Mm.27800 1810029G24Rik 160250_at AW049643 RIKEN cDNA 1810029G24 gene6083 0.32545 2.28 up Mm.200381 Capn3 99813_g_at X92523 calpain 36084 0.32552 1.59 down Mm.27005 Vsnl1 92995_at D21165 visinin-like 16085 0.32558 1.69 up Mm.175392 Defcr3 100351_f_at U02997 defensin related cryptdin 36086 0.32576 1.22 up Mm.1246 Irf1 102401_at M21065 interferon regulatory factor 16087 0.32576 1.54 up Mm.22699 Sepp1 95369_at AF021345 selenoprotein P, plasma, 16088 0.32577 1.73 up Mm.19109 Krt1-1 103558_at M27734 keratin complex 1, acidic, gene 16089 0.32579 1.94 up Mm.24765 C79397 161952_r_at AV361572 expressed sequence C793976090 0.32599 1.36 up Mm.1654 Mm.1654 103056_at AI849721 ESTs, Moderately similar to AF151806 1 CGI-48 protein [H.sapiens]6091 0.32602 1.58 up Mm.46793 Akp3 102147_at M61705 alkaline phosphatase 3, in<strong>test</strong>ine, not Mn requiring6092 0.32616 1.86 up Mm.16193 Muc1 103869_at U16175 mucin 1, transmembrane6093 0.32623 1.43 down Mm.34933 Mm.34933 97138_at C77335 ESTs6094 0.32635 1.12 down Mm.27445 Fbxo6b 95014_at AA794247 f-box only protein 6b6095 0.32642 1.26 up Mm.17640 Psmd10 103319_at AB022022 proteasome (prosome, macropain) 26S subunit, non-ATPase, 106096 0.32692 1.85 up Mm.4918 Nr3c1 98818_at X04435 nuclear receptor subfamily 3, group C, member 16097 0.32692 2.12 up Mm.4908 Csng 100463_at D10215 casein gamma6098 0.32714 1.36 up Mm.7156 Gpx3 101676_at U13705 glutathione peroxidase 36099 0.32717 1.34 up Mm.25988 Bcl2l10 96044_at AF067660 Bcl2-like 106100 0.32718 1.27 down Mm.172436 5830471E12Rik 103584_at AW124334 RIKEN cDNA 5830471E12 gene6101 0.32727 1.47 up Mm.8771 Pip5k2a 101865_at AB009615 phosphatidylinositol-4-phosphate 5-kinase, type II, alpha6102 0.32730 1.31 down Mm.26931 Eif2ak4 94941_at AJ243533 eukaryotic translation initiation factor 2 alpha kinase 46103 0.32748 1.27 down Mm.6354 Pigq 100594_at AB008895 phosphatidylinositol glycan, class Q6104 0.32763 2.10 up Mm.4803 Shc3 101149_at U46854 src homology 2 domain-containing transforming protein C36105 0.32768 1.59 up Mm.4372 Rorc 99951_at AF019660 RAR-related orphan receptor gamma6106 0.32777 1.19 down Mm.19788 Klf9 93528_s_at AI848050 Kruppel-like factor 96107 0.32799 1.59 up Mm.37312 Pign 92296_at AB030316 phosphatidylinositol glycan, class N6108 0.32806 1.67 down Mm.20249 Tyk2 97573_at AF052607 tyrosine kinase 26109 0.32816 1.76 up Mm.29564 Mmp2 95663_at M84324 matrix metalloproteinase 26110 0.32820 1.51 up Mm.4677 Irf4 92737_at U20949 interferon regulatory factor 46111 0.32829 1.23 up Mm.28941 Rab34 160317_at AI835712 RAB34, member of RAS oncogene family6112 0.32845 1.60 up Mm.57191 Vav 96511_s_at D83266 vav oncogene6113 0.32851 1.54 up Mm.4288 Sry 99555_at AF068054 sex determining region of Chr Y6114 0.32851 1.14 down Mm.21985 AW107754 160149_at AI841543 expressed sequence AW1077546115 0.32851 1.37 up Mm.27311 AI463227 94988_at AI840761 expressed sequence AI4632276116 0.32864 1.65 down Mm.28015 Pdzk1 97287_at AW046638 PDZ domain containing 16117 0.32873 2.58 up Mm.28738 C330027I04Rik 162046_at AV377022 RIKEN cDNA C330027I04 gene6118 0.32884 1.85 down Mm.23794 Mm.23794 99699_at AF014454 Mus musculus murine retrovirus readthrough RNA sequence6119 0.32885 1.29 down Mm.24309 Mm.24309 103731_at AI837319 ESTs, Moderately similar to TSC1_RAT HAMARTIN (TUBEROUS SCLERO6120 0.32887 1.68 up Mm.2464 AB041616 104731_at AI551347 hypothetical protein, MNCb-3350Page 68 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description6121 0.32891 1.12 down Mm.30246 Cd151 97932_f_at D89290 CD151 antigen6122 0.32896 1.97 up Mm.9001 Nlk 93935_at AF036332 nemo like kinase6123 0.32914 1.54 up Mm.1650 Expi 103051_at X93037 extracellular proteinase inhibitor6124 0.32921 1.61 up Mm.4577 Nr6a1 92696_at U09563 nuclear receptor subfamily 6, group A, member 16125 0.32934 2.53 up Mm.28917 1810045K17Rik 161908_i_at AV115292 RIKEN cDNA 1810045K17 gene6126 0.32948 1.20 up Mm.7524 Dag1 161183_at AV244370 dystroglycan 16127 0.32950 1.67 up Mm.1270 Prl 92803_at X04418 prolactin6128 0.32951 2.25 up Mm.3746 Naca 161669_r_at AV171080 nascent polypeptide-associated complex alpha polypeptide6129 0.32963 1.54 up Mm.36526 Spi12 103306_at AW259940 serine protease inhibitor 126130 0.32976 1.56 down Mm.6216 Cyp40 99836_at AB006034 cytochrome P450, 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase)6131 0.32983 1.70 up Mm.214491 Pld1 101628_g_at U87868 phospholipase D16132 0.32990 1.42 up Mm.27343 Emcn-pending 94997_at AF060883 endomucin6133 0.33022 1.30 down Mm.30016 C87222 96360_at AW125498 expressed sequence C872226134 0.33028 1.81 up Mm.20422 Nrl 102612_at L14935 neural retina leucine zipper gene6135 0.33038 1.65 up Mm.196619 6330415C05Rik 101022_at AI154281 RIKEN cDNA 6330415C05 gene6136 0.33040 1.27 up Mm.12951 Nme6 92824_at AF051942 expressed in non-metastatic cells 6, protein (nucleoside diphosphate kinase)6137 0.33049 1.29 up Mm.28780 Plxnb2 96464_at N28179 plexin B26138 0.33058 1.15 up Mm.4441 Epb7.2 100051_at U17297 erythrocyte protein band 7.26139 0.33081 1.66 up Mm.56957 Grin2b 101312_at D10651 glutamate receptor, ionotropic, NMDA2B (epsilon 2)6140 0.33087 1.24 up Mm.4182 Prkcb 99510_at X59274 protein kinase C, beta6141 0.33088 1.51 up Mm.214500 1810027O01Rik 92316_f_at J00592 RIKEN cDNA 1810027O01 gene6142 0.33092 1.29 up Mm.116802 Nfatc2 93073_at U36576 nuclear factor of activated T-cells, cytoplasmic 26143 0.33100 1.11 up Mm.29978 Egln2 96338_at AW125059 EGL nine homolog 2 (C. elegans)6144 0.33101 1.67 up Mm.29625 Mm.29625 97352_f_at AW123567 ESTs, Weakly similar to COXG MOUSE CYTOCHROME C OXIDASE POLY6145 0.33108 1.14 up Mm.139243 Mm.139243 104677_at AI852008 Mus musculus, Similar to alpha 1,2-mannosidase, clone IMAGE:3498155, m6146 0.33110 1.51 down Mm.28863 Fstl3 104452_at AI845896 follistatin-like 36147 0.33110 1.46 up Mm.8911 Psmb5 160559_at AV124768 proteasome (prosome, macropain) subunit, beta type 56148 0.33116 1.65 down 100672_at M334676149 0.33119 2.73 up Mm.31883 AI447669 100313_at AF041409 expressed sequence AI4476696150 0.33130 1.78 up Mm.182246 8430430L24Rik 162395_r_at AV272579 RIKEN cDNA 8430430L24 gene6151 0.33130 1.43 up Mm.26040 2610207P08Rik 97164_at C77566 RIKEN cDNA 2610207P08 gene6152 0.33136 1.34 up Mm.4269 Tcf4 160483_at U16322 transcription factor 46153 0.33136 1.13 down Mm.196846 Rad23b 96102_i_at X92411 RAD23b homolog (S. cerevisiae)6154 0.33148 1.68 up Mm.1315 Epx 94205_at D78353 eosinophil peroxidase6155 0.33194 1.66 up Mm.29725 Mapkapk2 160353_i_at X76850 MAP kinase-activated protein kinase 26156 0.33200 1.44 down Mm.139284 Mm.139284 98388_at AW049331 ESTs, Moderately similar to dJ101K10.1 [H.sapiens]6157 0.33212 1.52 up Mm.5046 Ptprj 92983_at D49393 protein tyrosine phosphatase, receptor type, J6158 0.33213 1.37 up Mm.199952 AW124433 93153_at AW124433 expressed sequence AW1244336159 0.33231 1.69 down Mm.28479 Lag 97910_at X94915 leukemia-associated gene6160 0.33236 1.23 up Mm.916 H2afz 101954_at U70494 H2A histone family, member Z6161 0.33256 2.01 up Mm.57107 Swap70 93218_at AF053974 SWAP complex protein, 70 kDa6162 0.33256 1.80 up Mm.371 Il4 92285_at AA967539 interleukin 46163 0.33267 1.66 up Mm.15085 Spi2-1 102860_at M64085 serine protease inhibitor 2-16164 0.33280 1.99 down Mm.216274 Mm.216274 97710_f_at AI425990 ESTs6165 0.33281 1.46 down Mm.205433 D18362 103206_at AI049099 expressed sequence D183626166 0.33284 3.56 up Mm.4263 Cst3 162240_r_at AV153157 cystatin C6167 0.33284 1.42 down Mm.182715 2700094G22Rik 95114_s_at AI844999 RIKEN cDNA 2700094G22 gene6168 0.33284 1.74 down Mm.127823 C77662 99364_at AI661370 expressed sequence C776626169 0.33286 1.84 up Mm.4598 Bcan 92700_at X87096 brevican6170 0.33307 1.42 down Mm.89564 Pnck 93910_at AB023027 pregnancy upregulated non-ubiquitously expressed CaM kinase6171 0.33314 1.43 down Mm.21203 AI227013 93773_f_at AI835041 expressed sequence AI2270136172 0.33320 2.17 up Mm.3471 Car1 98098_at M32452 carbonic anhydrase 16173 0.33321 1.34 up Mm.4387 Bad 161500_i_at AV102186 Bcl-associated death promoter6174 0.33332 1.38 up Mm.59041 2700097O09Rik 160980_at AI837288 RIKEN cDNA 2700097O09 gene6175 0.33342 1.82 up Mm.19973 0710008C12Rik 103594_at AW124512 RIKEN cDNA 0710008C12 gene6176 0.33350 1.74 down Mm.28981 Mm.28981 94513_r_at AI843210 Mus musculus, archain 1, clone MGC:27546 IMAGE:4480874, mRNA, comp6177 0.33353 1.61 up Mm.29098 AU015645 96789_i_at AW125222 expressed sequence AU0156456178 0.33363 1.68 up Mm.369 Abca1 94354_at AI845514 ATP-binding cassette, sub-family A (ABC1), member 16179 0.33381 1.67 up Mm.36640 Map3k6 92276_at AB021861 mitogen-activated protein kinase kinase kinase 66180 0.33393 1.16 down Mm.29683 1110002H15Rik 95698_at AI851810 RIKEN cDNA 1110002H15 gene6181 0.33399 1.58 up Mm.20427 Mm.20427 102613_at AF075717 Mus musculus transforming growth factor beta 1-induced factor 2 mRNA, co6182 0.33411 1.21 down Mm.218669 Tcea1 101527_at M18209 transcription elongation factor A (SII) 16183 0.33412 1.43 up Mm.5458 2600017H24Rik 100890_at AI173038 RIKEN cDNA 2600017H24 gene6184 0.33430 1.41 up Mm.4189 Ccna2 99186_at X75483 cyclin A26185 0.33431 1.24 up Mm.2509 Col6a1 95493_at X66405 procollagen, type VI, alpha 16186 0.33436 1.70 up Mm.28867 Tpp2 161537_f_at AV236858 tripeptidyl peptidase II6187 0.33436 1.21 up Mm.30057 AI648866 96864_at AI848770 expressed sequence AI6488666188 0.33437 1.20 down Mm.14722 Ywhaq 97061_g_at AW215489 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,6189 0.33439 4.54 up Mm.147387 Col3a1 102990_at AA655199 procollagen, type III, alpha 16190 0.33443 1.50 up Mm.4926 Pacsin1 92949_at X85124 protein kinase C and casein kinase substrate in neurons 16191 0.33455 1.25 up Mm.4429 Ube2e1 92660_f_at X92665 ubiquitin-conjugating enzyme E2E 1, UBC4/5 homolog (yeast)6192 0.33457 1.42 up Mm.150 Fcgr1 102879_s_at M31314 Fc receptor, IgG, high affinity I6193 0.33458 1.55 up Mm.20827 Hipk1 103262_at AF077658 homeodomain interacting protein kinase 16194 0.33458 1.98 up 97561_at AF0273016195 0.33474 1.63 up Mm.4921 Gria2 92945_at L32372 glutamate receptor, ionotropic, AMPA2 (alpha 2)6196 0.33479 1.90 up Mm.158 AV253284 102907_at AW125043 expressed sequence AV2532846197 0.33481 1.52 up Mm.2470 2610201A13Rik 95927_f_at AA222883 RIKEN cDNA 2610201A13 gene6198 0.33494 1.36 up Mm.4956 Fgf4 98826_at X14849 fibroblast growth factor 46199 0.33495 2.66 up Mm.29254 Igfbp3 95082_at AI842277 insulin-like growth factor binding protein 36200 0.33503 1.51 down Mm.87808 Raet1c 102649_s_at D64162 retinoic acid early transcript gamma6201 0.33504 1.31 up Mm.16771 H2-K 93120_f_at V00746 histocompatibility 2, K region6202 0.33514 1.25 down Mm.27918 5730434B08Rik 95596_at AW122957 RIKEN cDNA 5730434B08 gene6203 0.33518 1.21 up Mm.17989 Cct8 160102_at Z37164 chaperonin subunit 8 (theta)6204 0.33521 1.20 down Mm.2033 2700033I16Rik 93562_at AI854366 RIKEN cDNA 2700033I16 gene6205 0.33547 1.26 down Mm.4114 Slc3a2 99133_at X14309 solute carrier family 3 (activators of dibasic and neutral amino acid transport)6206 0.33549 1.26 down Mm.28223 Idb4 96144_at AJ001972 inhibitor of DNA binding 46207 0.33553 1.18 down Mm.89515 Snx9 160593_at AW120567 sorting nexin 96208 0.33558 1.41 down Mm.5071 Sema3c 101178_at X85994 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (se6209 0.33560 1.82 up Mm.2161 Apom 93840_at AA655303 apolipoprotein M6210 0.33560 1.10 down Mm.46790 2210016F16Rik 160513_at AA646408 RIKEN cDNA 2210016F16 genePage 69 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description6211 0.33564 1.23 down Mm.967 AI848598 93962_at AI848598 expressed sequence AI8485986212 0.33578 1.40 up Mm.488 Selel 94364_at AI847926 selectin, endothelial cell, ligand6213 0.33583 1.26 down Mm.7414 Nsg1 101099_at M98530 neuron specific gene family member 16214 0.33597 1.89 up Mm.10563 Mtf2 161470_r_at AV354760 metal response element binding transcription factor 26215 0.33601 1.82 up Mm.3810 Pik3c2a 92312_at U55772 phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide6216 0.33604 1.45 up Mm.2827 Ngp 96153_at L37297 neutrophilic granule protein6217 0.33604 2.23 up Mm.24491 AA408511 160973_at AA590345 expressed sequence AA4085116218 0.33612 1.34 down Mm.193041 Map3k7ip2 160309_at AW259500 mitogen-activated protein kinase kinase kinase 7 interacting protein 26219 0.33613 1.36 down Mm.23118 1300008P06Rik 161333_f_at AV115644 RIKEN cDNA 1300008P06 gene6220 0.33613 2.17 up Mm.45436 Lyzs 162309_at AV014891 lysozyme6221 0.33648 1.48 up Mm.10112 Alx3 96423_at U96109 aristaless 36222 0.33654 1.65 down Mm.200122 Mm.200122 94227_at M27685 Mus musculus 10 days neonate head cDNA, RIKEN full-length enriched libra6223 0.33668 1.29 up Mm.12959 Grpel2 102761_at AF041060 GrpE-like 2, mitochondrial6224 0.33682 1.57 up Mm.19307 Ltbp1 103209_at AF022889 latent transforming growth factor beta binding protein 16225 0.33693 1.79 up 102076_at AJ2359406226 0.33697 1.21 up Mm.2018 Cbfb 93547_at L03279 core binding factor beta6227 0.33716 1.64 up Mm.22727 D17Wsu51e 104392_at AI122121 DNA segment, Chr 17, Wayne State University 51, expressed6228 0.33718 1.61 up Mm.35807 2010004N24Rik 160436_at AI854272 RIKEN cDNA 2010004N24 gene6229 0.33720 1.70 up Mm.87835 V2r12 101353_at AF022252 vomeronasal 2, receptor, 126230 0.33734 1.48 up Mm.3732 Mail-pending 98988_at AA614971 molecule possessing ankyrin-repeats induced by lipopolysaccharide6231 0.33753 1.37 up Mm.29890 2700043D08Rik 162458_i_at AV009978 RIKEN cDNA 2700043D08 gene6232 0.33754 1.20 down Mm.24821 1200013P24Rik 160195_at AI846961 RIKEN cDNA 1200013P24 gene6233 0.33757 1.34 down Mm.5572 D1Ertd147e 93191_at AW061328 DNA segment, Chr 1, ERATO Doi 147, expressed6234 0.33764 1.62 up Mm.22645 AW212954 104373_at AW046876 expressed sequence AW2129546235 0.33775 1.80 up Mm.22629 Krt2-6a 104370_s_at K02108 keratin complex 2, basic, gene 6a6236 0.33801 1.25 down Mm.21096 Eral1 103858_at AW124023 Era (G-protein)-like 1 (E. coli)6237 0.33811 1.45 up Mm.64458 Mm.64458 161493_at AV090440 EST6238 0.33811 1.34 up Mm.144235 Pxf 95074_at AW125309 peroxisomal farnesylated protein6239 0.33812 1.51 up Mm.38011 Bri3 96037_at X61454 brain protein I36240 0.33814 1.26 down Mm.29800 Cdc25a 97390_at AW125294 cell division cycle 25 homolog A (S. cerevisiae)6241 0.33820 1.61 down Mm.5187 Glrp1 101197_at U46463 glutamine repeat protein 16242 0.33836 1.26 up Mm.22746 2210416J16Rik 94829_at AW121838 RIKEN cDNA 2210416J16 gene6243 0.33853 1.43 up Mm.8059 Sema4b 94637_at X85992 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) an6244 0.33868 1.14 up Mm.10433 Aip 92575_at U85489 aryl-hydrocarbon receptor-interacting protein6245 0.33871 1.52 up Mm.181833 8430404F20Rik 92325_at AI326889 RIKEN cDNA 8430404F20 gene6246 0.33876 1.83 up Mm.57004 H2-M9 101299_at M20985 histocompatibility 2, M region locus 96247 0.33876 1.60 up Mm.4674 Melk 100416_at L76158 maternal embryonic leucine zipper kinase6248 0.33879 1.79 up Mm.6333 E2f3 93405_at AF015948 E2F transcription factor 36249 0.33896 1.65 up Mm.88845 Olfr37e 97003_at AJ133428 olfactory receptor 37e6250 0.33898 1.39 up Mm.30177 2700047N05Rik 96932_at AA915342 RIKEN cDNA 2700047N05 gene6251 0.33898 1.40 up Mm.29847 Mm.29847 96269_at AA716963 Mus musculus, Similar to isopentenyl-diphosphate delta isomerase, clone MG6252 0.33909 1.16 down Mm.22264 Apg5l 94225_at AI844679 autophagy 5-like6253 0.33910 1.32 up Mm.4181 Jak3 99509_s_at L40172 Janus kinase 36254 0.33911 1.65 up Mm.1478 Efna2 102869_at U14941 ephrin A26255 0.33915 1.68 up Mm.19353 LOC56304 102155_f_at K03461 recombinant antineuraminidase single chain Ig VH and VL domains6256 0.33916 6.07 up Mm.14431 Gzmf 102822_at J03257 granzyme F6257 0.33916 1.10 up Mm.28092 0610009E20Rik 160267_at AI845987 RIKEN cDNA 0610009E20 gene6258 0.33919 1.68 up Mm.218620 R75030 99337_at AI844631 expressed sequence R750306259 0.33921 1.47 up Mm.4352 Col15a1 162483_f_at AV112006 procollagen, type XV6260 0.33929 1.88 up Mm.1361 Cga 94700_at J00643 glycoprotein hormones, alpha subunit6261 0.33936 1.45 up Mm.14438 AU044919 102844_at D78344 expressed sequence AU0449196262 0.33937 2.90 up Mm.34899 AA517864 97134_at AA517864 expressed sequence AA5178646263 0.33939 1.34 up Mm.29906 Ebp2 96297_at AI845934 EBNA1 binding protein 26264 0.33939 1.63 up Mm.43568 Fzd3 98348_at U43205 frizzled homolog 3 (Drosophila)6265 0.33940 2.00 up Mm.8054 Tacr2 94634_at X62933 tachykinin receptor 26266 0.33943 1.24 down Mm.28219 Mm.28219 97829_at AI838053 Mus musculus, Similar to CDP-diacylglycerol--inositol 3-phosphatidyltransfer6267 0.33944 1.50 up Mm.14145 Mm.14145 102695_at AF021335 Mus musculus, Similar to T-cell receptor gamma, variable 4, clone MGC:6236268 0.33962 1.30 down Mm.39586 Mm.39586 101697_f_at AI844607 EST6269 0.33970 1.23 down Mm.2938 Igf2r 95117_at U04710 insulin-like growth factor 2 receptor6270 0.33976 1.33 down Mm.202695 AI843066 103447_at AI835989 expressed sequence AI8430666271 0.33977 1.24 down Mm.182921 2310061B02Rik 95520_at AI843845 RIKEN cDNA 2310061B02 gene6272 0.33981 1.30 up Mm.29542 AI256843 95658_at AW061085 expressed sequence AI2568436273 0.34003 1.67 up Mm.39086 Adra1b 92340_at Y12738 adrenergic receptor, alpha 1b6274 0.34007 1.56 up Mm.6072 Clta 100580_at AA896182 clathrin, light polypeptide (Lca)6275 0.34007 1.27 down Mm.2701 Dnajb6 96120_at AW124750 DnaJ (Hsp40) homolog, subfamily B, member 66276 0.34038 1.57 up Mm.87279 Mef2a 94133_r_at U94423 myocyte enhancer factor 2A6277 0.34040 1.38 down Mm.46801 Mm.46801 96963_s_at L14553 M.musculus mRNA (2F7) for IgA V-D-J-heavy chain6278 0.34042 1.53 up Mm.32580 1200014O24Rik 161556_at AV256180 RIKEN cDNA 1200014O24 gene6279 0.34048 2.11 up Mm.153963 Cd8b 162410_s_at AV316162 CD8 antigen, beta chain6280 0.34052 1.70 up Mm.141399 2310068B06Rik 161732_at AV273779 RIKEN cDNA 2310068B06 gene6281 0.34055 1.74 up Mm.205791 Atp1a1 93796_at AW123952 ATPase, Na+/K+ transporting, alpha 1 polypeptide6282 0.34068 1.82 up Mm.214545 6230410J09Rik 160418_at AI852085 RIKEN cDNA 6230410J09 gene6283 0.34070 1.22 down Mm.20175 2810431B21Rik 103608_at AI842636 RIKEN cDNA 2810431B21 gene6284 0.34080 1.25 down Mm.39472 Mm.39472 99098_at AW045533 Mus musculus farnesyl pyrophosphate synthase (Fpps) mRNA, complete cd6285 0.34099 1.44 up Mm.1114 Gla 94832_at U58105 galactosidase, alpha6286 0.34117 1.32 up Mm.56685 Iqgap1 100561_at AW209098 IQ motif containing GTPase activating protein 16287 0.34128 1.55 down Mm.4083 Sema3b 161801_r_at AV369830 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (se6288 0.34146 1.43 up Mm.35300 Aire 97159_at AJ007715 autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectoder6289 0.34189 1.76 up Mm.638 Mm.638 93411_at AI152789 ESTs6290 0.34191 1.86 up Mm.16710 Impnb 161936_at AV330502 importin beta6291 0.34192 1.96 up Mm.1357 Asgr2 102662_at X53042 asialoglycoprotein receptor 26292 0.34206 1.81 up Mm.196415 Magea8 103291_at AJ005532 melanoma antigen, family A, 86293 0.34208 1.61 down Mm.16525 Plk 101349_at U73170 polo-like kinase homolog, (Drosophila)6294 0.34208 1.24 up Mm.200372 Coro1c 98107_at AW123801 coronin, actin binding protein 1C6295 0.34210 1.98 down Mm.29183 Mrpl2 161910_at AV119058 mitochondrial ribosomal protein L26296 0.34252 1.43 up Mm.24475 Mm.24475 103745_at AW227027 ESTs, Moderately similar to T48681 hypothetical protein DKFZp761E0611.16297 0.34258 1.66 up Mm.180333 Mutyh 96558_at AI049068 mutY homolog (E. coli)6298 0.34267 1.32 up Mm.6148 Mm.6148 99828_at AA673252 ESTs6299 0.34269 1.37 down Mm.30728 Arpp19-pending 97259_at AJ005983 cyclic AMP phosphoprotein, 19 kDa6300 0.34269 1.76 up Mm.12407 Creb3 92784_at AI841599 cAMP responsive element binding protein 3Page 70 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description6301 0.34280 1.47 up Mm.57200 Chrm1 101829_at J04192 cholinergic receptor, muscarinic 1, CNS6302 0.34282 1.67 down Mm.8031 Fmr2 99912_at AJ001549 fragile X mental retardation 2 homolog6303 0.34282 14.56 up Mm.14424 Gzme 102728_f_at M36901 granzyme E6304 0.34302 1.93 up Mm.41498 Mc2r 92429_at D31952 melanocortin 2 receptor6305 0.34308 1.50 up Mm.42041 Insrr 98279_at AB007135 insulin receptor-related receptor6306 0.34313 1.65 up Mm.206824 1810057I13Rik 101863_at C78246 RIKEN cDNA 1810057I13 gene6307 0.34326 1.42 up Mm.6735 Prep 100983_at AB022053 prolyl endopeptidase6308 0.34352 1.32 up Mm.25269 AA408648 94363_at AI840815 EST AA4086486309 0.34353 1.37 up Mm.667 Gstm5 100630_f_at AA241764 glutathione S-transferase, mu 56310 0.34362 1.68 up Mm.29363 2310044F10Rik 162433_f_at AV299073 RIKEN cDNA 2310044F10 gene6311 0.34364 1.99 up Mm.25210 0910001K16Rik 95509_at AA607809 RIKEN cDNA 0910001K16 gene6312 0.34375 1.89 down Mm.4569 Nin 92693_at U40342 ninein6313 0.34381 2.10 down Mm.57063 Cmar 101739_at Z50147 cell matrix adhesion regulator6314 0.34389 1.46 up Mm.12810 Tnfrsf8 98728_at U25416 tumor necrosis factor receptor superfamily, member 86315 0.34389 1.82 up Mm.57007 Kist 99401_at Y10725 kinase interacting with leukemia-associated gene (stathmin)6316 0.34389 1.41 down Mm.21406 C330016H24Rik 103908_at AW121857 RIKEN cDNA C330016H24 gene6317 0.34393 1.93 up Mm.81458 Mm.81458 162208_f_at AV077940 EST6318 0.34393 1.61 up Mm.90115 Lypla1 101945_g_at U89352 lysophospholipase 16319 0.34395 1.47 up Mm.2534 Pstpip1 161244_f_at AV312229 proline-serine-threonine phosphatase-interacting protein 16320 0.34397 1.45 up Mm.3737 AA408954 100747_at AA408954 expressed sequence AA4089546321 0.34398 1.89 up Mm.1417 Rptn 94732_at X99251 repetin6322 0.34400 1.72 up Mm.139091 Mm.139091 161944_at AV209747 EST6323 0.34401 1.30 down Mm.25293 Pcmt1 95512_at M60320 protein-L-isoaspartate (D-aspartate) O-methyltransferase 16324 0.34409 1.44 up Mm.20371 Mm.20371 103241_at AA036065 ESTs, Weakly similar to ADENYLATE CYCLASE, TYPE VII [M.musculus]6325 0.34411 1.55 up Mm.4955 Kcne1 98825_at X60457 potassium voltage-gated channel, Isk-related subfamily, member 16326 0.34429 1.27 down Mm.27714 3230401N03Rik 97211_at AI747444 RIKEN cDNA 3230401N03 gene6327 0.34447 1.15 down Mm.200971 AI894167 96184_at AI835242 expressed sequence AI8941676328 0.34449 2.54 up Mm.4875 Dll1 161634_r_at AV007019 delta-like 1 (Drosophila)6329 0.34459 1.29 down Mm.3561 5033414D02Rik 98495_at AI846906 RIKEN cDNA 5033414D02 gene6330 0.34462 1.30 down Mm.46513 2610200G18Rik 162249_f_at AV334573 RIKEN cDNA 2610200G18 gene6331 0.34467 1.35 up Mm.200507 Tbce 160140_at AI852161 tubulin-specific chaperone e6332 0.34467 1.82 up Mm.18539 1190006F07Rik 93322_at AI849570 RIKEN cDNA 1190006F07 gene6333 0.34493 1.79 up Mm.6824 Sultn-pending 160537_at AF026073 amine N-sulfotransferase6334 0.34499 1.50 up Mm.222 Trp53 104154_at AB021961 transformation related protein 536335 0.34500 1.54 down Mm.27822 Apobec2 97234_at AA792453 apolipoprotein B editing complex 26336 0.34506 1.72 up Mm.4766 Vmp 92892_at D83206 vesicular membrain protein p246337 0.34510 1.40 up Mm.41568 Mm.41568 92432_at AI844359 ESTs, Weakly similar to ZF93_MOUSE ZINC FINGER PROTEIN 93 (ZFP-936338 0.34516 1.61 up Mm.157101 C330007P06Rik 161963_f_at AV367333 RIKEN cDNA C330007P06 gene6339 0.34520 2.11 up Mm.153097 Adam4 92733_at U22058 a disintegrin and metalloprotease domain 46340 0.34529 1.52 up Mm.36715 2600009M07Rik 98552_at AW060657 RIKEN cDNA 2600009M07 gene6341 0.34531 1.42 up Mm.56167 5730497N19Rik 160632_at AW124627 RIKEN cDNA 5730497N19 gene6342 0.34535 3.92 up Mm.145 Scya2 102736_at M19681 small inducible cytokine A26343 0.34551 1.16 up Mm.29067 AI194990 94352_at AI850675 expressed sequence AI1949906344 0.34556 1.38 up Mm.25283 AI893437 103942_at AA607375 expressed sequence AI8934376345 0.34559 1.52 up 101792_at V007896346 0.34567 1.21 up Mm.20914 Rps6ka4 93602_at AF074714 ribosomal protein S6 kinase, 90kD, polypeptide 46347 0.34600 1.40 up Mm.8038 Zap70 93663_r_at AI386093 zeta-chain (TCR) associated protein kinase (70kD)6348 0.34619 1.53 up Mm.4509 Runx2 161378_r_at AV245229 runt related transcription factor 26349 0.34636 1.77 up Mm.41976 Cdh8 101701_at X95600 cadherin 86350 0.34643 1.16 down Mm.140365 Eif2b 95046_s_at M98036 eukaryotic translation initiation factor 2B6351 0.34644 1.38 up Mm.35806 2300002G24Rik 98519_r_at AI604345 RIKEN cDNA 2300002G24 gene6352 0.34652 1.49 down Mm.20457 Chrd 103249_at AF069501 chordin6353 0.34677 1.31 up Mm.4206 4432417N03Rik 99523_at AA684502 RIKEN cDNA 4432417N03 gene6354 0.34682 1.79 up Mm.3086 Pet2 96597_at M95564 plasmacytoma expressed transcript 26355 0.34697 1.56 up Mm.3951 Thy1 99057_at M12379 thymus cell antigen 1, theta6356 0.34709 1.34 down Mm.41656 AW457192 99159_at AI842675 expressed sequence AW4571926357 0.34709 1.81 up Mm.24647 AU046135 104735_at AI842065 expressed sequence AU0461356358 0.34712 1.92 up Mm.27685 Mm.27685 95543_at AI843046 ESTs, Moderately similar to TROPOMYOSIN 5, CYTOSKELETAL TYPE [M.6359 0.34721 1.21 down Mm.21705 1110049G11Rik 104078_g_at AW121992 RIKEN cDNA 1110049G11 gene6360 0.34729 1.28 up Mm.34548 1810013K23Rik 102943_at AI099344 RIKEN cDNA 1810013K23 gene6361 0.34734 1.40 down Mm.22628 AI790651 162332_f_at AV091649 expressed sequence AI7906516362 0.34740 1.34 up Mm.1840 Cyp4b1 103353_f_at D50834 cytochrome P450, subfamily IV B, polypeptide 16363 0.34751 3.90 up Mm.4575 Cspg2 100019_at D45889 chondroitin sulfate proteoglycan 26364 0.34776 1.59 up Mm.25008 C79052 95879_at C79052 expressed sequence C790526365 0.34786 1.57 up Mm.99 Rrm2 100349_at C79615 ribonucleotide reductase M26366 0.34789 1.55 down Mm.21640 9430016H08Rik 160958_at AA178265 RIKEN cDNA 9430016H08 gene6367 0.34805 1.41 down Mm.90760 Mm.90760 101582_at AI853259 Mus musculus, Similar to nucleolar GTPase, clone MGC:7863 IMAGE:350136368 0.34806 1.36 up Mm.4292 Tieg 99603_g_at AF064088 TGFB inducible early growth response6369 0.34816 1.68 down Mm.14112 Klra6 100674_f_at U10092 killer cell lectin-like receptor, subfamily A, member 66370 0.34817 1.34 down Mm.31267 AA408228 104643_at AI850846 expressed sequence AA4082286371 0.34825 1.61 up Mm.22480 Dmtf1 94272_g_at U70017 cyclin D binding myb-like transcription factor 16372 0.34827 1.29 down Mm.24104 Mprs17 94909_at AW046919 mitochondrial ribosomal protein S176373 0.34834 1.48 up Mm.206653 Mm.206653 161798_r_at AV349827 ESTs6374 0.34837 3.20 up Mm.41931 Mfap5-pending 99518_at AW121179 microfibrillar associated protein 56375 0.34851 1.45 down Mm.2556 Azi1 103956_at D88509 5-azacytidine induced gene 16376 0.34853 1.40 up Mm.3881 Tcf15 97717_at U18658 transcription factor 156377 0.34856 1.20 down Mm.18959 Stx18 160635_at AI849070 syntaxin 186378 0.34870 1.60 up Mm.2165 Sap 104072_at M23552 serum amyloid P-component6379 0.34880 1.67 up Mm.736 Sh3d2c2 101412_at U58887 SH3 domain protein 2 C26380 0.34883 2.47 up Mm.24816 F2r 95474_at AW123850 coagulation factor II (thrombin) receptor6381 0.34886 1.54 up Mm.130425 Npn1 101168_at Z31360 neoplastic progression 16382 0.34892 1.49 up Mm.25765 Mm.25765 103976_at AI158159 ESTs6383 0.34897 1.42 up Mm.1881 AI325941 103408_at AI007117 expressed sequence AI3259416384 0.34926 1.62 down Mm.735 Fbn1 162170_r_at AV363605 fibrillin 16385 0.34928 1.61 up Mm.28148 Cbx3 100405_at X56683 chromobox homolog 3 (Drosophila HP1 gamma)6386 0.34932 1.31 down Mm.4719 Fdxr 92754_at D49920 ferredoxin reductase6387 0.34933 1.73 up Mm.2924 Pdgfra 95079_at M57683 platelet derived growth factor receptor, alpha polypeptide6388 0.34945 1.63 up Mm.3386 Dtna 92184_at X95226 dystrobrevin alpha6389 0.34946 1.21 down Mm.28123 Fastk 97800_at AI837308 Fas-activated serine/threonine kinase6390 0.34954 1.62 up Mm.147354 Gabrg1 100372_at X55272 gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 1Page 71 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description6391 0.34955 1.57 up Mm.4213 Gdf3 92476_at L06443 growth differentiation factor 36392 0.34956 1.69 up Mm.3946 Trhr 97735_at M59811 thyrotropin releasing hormone receptor6393 0.34957 1.48 down Mm.103427 Mm.103427 96545_s_at AI447510 ESTs, Highly similar to unnamed protein product [H.sapiens]6394 0.34959 1.83 up Mm.6611 Slc27a2 100967_at AF072757 solute carrier family 27 (fatty acid transporter), member 26395 0.34979 1.48 up Mm.26262 Mos 96521_at J00372 Moloney sarcoma oncogene6396 0.34989 1.34 up Mm.1216 Mgmt 102285_at M84524 0-6-methylguanine-DNA methyltransferase6397 0.34992 1.48 up Mm.3536 Myo5b 161747_i_at AV321353 myosin Vb6398 0.34996 1.47 up Mm.20913 Swap2-pending 103822_at AF042799 suppressor of white apricot homolog 2-pending6399 0.34996 1.32 up Mm.19065 Pscd3 103433_at AI846077 pleckstrin homology, Sec7 and coiled/coil domains 36400 0.34997 1.46 down Mm.20469 Hif3a 95336_at AF060194 hypoxia inducible factor 3, alpha subunit6401 0.34998 1.55 up Mm.30276 Spt2 101636_at M33975 salivary protein 26402 0.35007 1.57 down Mm.6510 Zp2 93429_at M34148 zona pellucida glycoprotein 26403 0.35007 1.62 up 92742_at U774626404 0.35011 1.50 up Mm.197950 C79210 104222_f_at C79210 expressed sequence C792106405 0.35019 1.89 up Mm.179011 Vav2 162035_f_at AV259885 Vav2 oncogene6406 0.35022 1.31 down Mm.22409 Clic4 94256_at AI849533 chloride intracellular channel 4 (mitochondrial)6407 0.35023 1.28 down Mm.14796 Mgst1 93026_at AW124337 microsomal glutathione S-transferase 16408 0.35028 1.41 up Mm.21126 AI447817 104612_g_at AI854008 expressed sequence AI4478176409 0.35043 1.27 up Mm.1021 Vcam1 92560_g_at U12884 vascular cell adhesion molecule 16410 0.35083 1.55 up Mm.19073 9430080K19Rik 103435_at AW045910 RIKEN cDNA 9430080K19 gene6411 0.35099 1.33 down Mm.21667 Psmd12 93971_f_at AI838669 proteasome (prosome, macropain) 26S subunit, non-ATPase, 126412 0.35107 1.32 up Mm.9286 Rad51l3 101924_at AF034955 RAD51-like 3 (S. cerevisiae)6413 0.35108 1.92 up Mm.12871 Dcx 102307_at AB011678 doublecortin6414 0.35112 1.59 up Mm.4814 Neurod2 98808_at D83507 neurogenic differentiation 26415 0.35112 1.45 down Mm.22633 Dgat1 162316_f_at AV063528 diacylglycerol O-acyltransferase 16416 0.35125 1.37 up Mm.298 Mm.298 93506_at AW121063 Mus musculus, Similar to solute carrier family 25 (mitochondrial carrier; phos6417 0.35127 1.31 up Mm.3388 Mm.3388 92185_at AI846023 ESTs, Weakly similar to ADP-ribosylation-like 4 [Mus musculus] [M.musculu6418 0.35154 1.32 up Mm.23825 Mrpl20 94875_at AI838915 mitochondrial ribosomal protein L206419 0.35158 1.41 up Mm.5289 Gapd 162176_r_at AV008547 glyceraldehyde-3-phosphate dehydrogenase6420 0.35161 1.60 up Mm.22753 Ctsb 162271_f_at AV363907 cathepsin B6421 0.35181 1.28 up Mm.200874 AI851081 96732_at AI851081 expressed sequence AI8510816422 0.35189 1.45 up Mm.4258 Ogn 160877_at AA647799 osteoglycin6423 0.35190 1.44 up Mm.29755 Incenp 104468_at AW045530 inner centromere protein6424 0.35195 1.22 down Mm.24276 C1r 95415_f_at AI132585 complement component 1, r subcomponent6425 0.35232 1.36 up Mm.4953 Frk 92959_at Z48757 B-cell src-homology tyrosine kinase6426 0.35239 1.39 up Mm.136604 Nfil3 102955_at U83148 nuclear factor, interleukin 3, regulated6427 0.35250 1.18 up Mm.2849 Hspa9a 97914_at D17666 heat shock protein, 74 kDa, A6428 0.35257 1.31 down Mm.8684 Agpat1 93720_at AB005623 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltr6429 0.35278 1.56 up Mm.34158 2810407E23Rik 95944_at AV299153 RIKEN cDNA 2810407E23 gene6430 0.35281 1.41 up Mm.183043 2300003P22Rik 95740_at AA727291 RIKEN cDNA 2300003P22 gene6431 0.35284 1.42 up Mm.171337 Mm.171337 96053_i_at Y17345 Mus musculus mRNA for protein-tyrosine-phosphatase IF16432 0.35285 1.49 up Mm.4831 Htr3a 92919_at M74425 5-hydroxytryptamine (serotonin) receptor 3A6433 0.35290 1.76 up Mm.41060 C81219 96570_at AV381276 expressed sequence C812196434 0.35301 1.42 up Mm.144157 Ghrh 100938_at M31658 growth hormone releasing hormone6435 0.35304 1.44 up Mm.22637 0910001L24Rik 161243_f_at AV284333 RIKEN cDNA 0910001L24 gene6436 0.35318 3.12 up Mm.6120 Fbln2 100928_at X75285 fibulin 26437 0.35319 1.25 down Mm.186 1300011C24Rik 93327_at AI842665 RIKEN cDNA 1300011C24 gene6438 0.35319 1.33 up Mm.8033 Chad 99913_at U96626 chondroadherin6439 0.35325 1.35 down Mm.203310 2410074K14Rik 100492_at AW122807 RIKEN cDNA 2410074K14 gene6440 0.35328 1.45 down Mm.57210 Olfr16 102554_at X92969 olfactory receptor 166441 0.35346 1.15 up Mm.27607 Ranbp16 102476_f_at AW121303 RAN binding protein 166442 0.35358 1.45 up Mm.140568 1100001I22Rik 96309_r_at AI746498 RIKEN cDNA 1100001I22 gene6443 0.35359 1.38 up Mm.1008 Ptgds 102105_f_at AI840733 prostaglandin D2 synthase (21 kDa, brain)6444 0.35368 1.19 up Mm.215172 Plec1 103855_at AW123286 plectin 16445 0.35370 2.08 up Mm.6575 Cyp24 93435_at D89669 cytochrome P450, 246446 0.35376 1.29 down Mm.4596 Zfp97 98761_i_at L20450 zinc finger protein 976447 0.35381 1.14 up Mm.4653 TgN737Rpw 100404_at L31959 transgene insert site 737, insertional mutation, polycystic kidney disease6448 0.35383 1.43 down Mm.2418 Zfp144 103718_at D90085 zinc finger protein 1446449 0.35389 1.67 up Mm.24385 Mm.24385 162154_i_at AV333872 ESTs6450 0.35392 1.28 down Mm.8155 Tgif 101502_at X89749 TG interacting factor6451 0.35395 1.55 up Mm.200381 Capn3 99812_at X92523 calpain 36452 0.35396 1.75 up Mm.46172 Mm.46172 160506_at AA673494 Mus musculus cAMP-dependent protein kinase regulatory subunit mRNA, co6453 0.35402 1.45 down Mm.3938 Adora2b 97733_at U05673 adenosine A2b receptor6454 0.35403 1.48 up Mm.25058 C80012 95994_at C80007 expressed sequence C800126455 0.35452 1.43 down Mm.20890 Mbd4 103285_at AF072249 methyl-CpG binding domain protein 46456 0.35453 1.62 down Mm.29966 Ptbp2 94088_at AW228429 polypyrimidine tract binding protein 26457 0.35469 1.70 down Mm.1452 Cd86 102831_s_at U39456 CD86 antigen6458 0.35471 1.22 down Mm.29005 AU021749 96762_at AW046160 expressed sequence AU0217496459 0.35478 1.45 up Mm.196424 Prlpg 101874_s_at AF020525 prolactin-like protein G6460 0.35505 1.33 down Mm.219445 Carm1-pending 99169_at AW122165 coactivator-associated arginine methyltransferase 16461 0.35513 1.31 down Mm.4789 Ank1 100440_f_at U76758 ankyrin 1, erythroid6462 0.35524 1.57 down Mm.1078 Mm.1078 94129_at AA164101 ESTs6463 0.35527 1.65 up Mm.42046 Park2 102073_at AB019558 parkin6464 0.35532 1.22 up Mm.29809 2410015J15Rik 97392_at AW050086 RIKEN cDNA 2410015J15 gene6465 0.35534 1.33 down Mm.8687 Cap1 93721_at L12367 adenylyl cyclase-associated CAP protein homolog 1 (S. cerevisiae, S. pombe6466 0.35541 1.62 up Mm.1283 Scya1 94165_at M23501 small inducible cytokine A16467 0.35544 1.42 down Mm.4770 Fzd7 101143_at U43320 frizzled homolog 7 (Drosophila)6468 0.35548 1.28 down Mm.36894 Tcf12 98981_s_at X64840 transcription factor 126469 0.35551 1.68 up Mm.2954 AI552542 104457_at AI639614 expressed sequence AI5525426470 0.35560 2.30 up Mm.18652 Sms 96995_at AJ245865 spermine synthase6471 0.35594 1.46 up Mm.11480 2810470K21Rik 160585_at AA867497 RIKEN cDNA 2810470K21 gene6472 0.35608 1.28 up Mm.57076 Bdkrb 101748_at U47281 bradykinin receptor, beta6473 0.35610 2.10 up Mm.339 AI596198 97119_at AI596198 expressed sequence AI5961986474 0.35625 1.59 up Mm.190034 Mm.190034 161578_r_at AV356510 EST6475 0.35625 1.55 up Mm.214642 Mm.214642 104450_at U15647 Mus musculus zinc finger protein 352 mRNA, complete cds6476 0.35632 1.75 up Mm.6120 Fbln2 161930_r_at AV321999 fibulin 26477 0.35633 1.23 up Mm.193088 Clcn4-2 104704_at AI837630 chloride channel 4-26478 0.35642 1.35 up Mm.1065 Mm.1065 94113_at AA163908 ESTs6479 0.35646 1.48 up Mm.23828 2410041F14Rik 103553_at AA867646 RIKEN cDNA 2410041F14 gene6480 0.35660 1.61 up Mm.111789 AI848406 95288_i_at AA189811 expressed sequence AI848406Page 72 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description6481 0.35676 1.55 up Mm.56987 Opn1sw 99395_at U92562 opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)6482 0.35677 1.32 down Mm.171292 2010200I23Rik 95613_at AW122573 RIKEN cDNA 2010200I23 gene6483 0.35687 1.24 down Mm.200785 AI427066 160630_at AW123599 expressed sequence AI4270666484 0.35691 1.21 down Mm.88188 Ddx3 101542_f_at L25126 DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 36485 0.35705 1.34 up Mm.2952 Fen1 97327_at L26320 flap structure specific endonuclease 16486 0.35713 1.65 up Mm.42052 Mcpt-ps1 102075_at X78543 mast cell protease, pseudogene 16487 0.35755 1.52 up Mm.4707 Gabrb2 101138_at U14419 gamma-aminobutyric acid (GABA-A) receptor, subunit beta 26488 0.35765 1.27 up Mm.29456 Pgls 95147_at AI843795 6-phosphogluconolactonase6489 0.35771 1.81 down Mm.56930 Kcna2 99380_at M30440 potassium voltage-gated channel, shaker-related subfamily, member 26490 0.35776 1.29 down Mm.157135 2610023M21Rik 96266_at AI841982 RIKEN cDNA 2610023M21 gene6491 0.35787 1.81 up Mm.35531 Myh4 98488_at AJ223361 myosin, heavy polypeptide 4, skeletal muscle6492 0.35792 1.31 down Mm.2898 Bcl7c 96753_at Y11905 B-cell CLL/lymphoma 7C6493 0.35793 1.25 down Mm.2012 Eps8 103222_at L21671 epidermal growth factor receptor pathway substrate 86494 0.35802 2.08 up Mm.196718 Hbb-bh1 161501_at AV111846 hemoglobin Z, beta-like embryonic chain6495 0.35819 1.47 up Mm.193 Itm2a 93511_at L38971 integral membrane protein 2A6496 0.35827 1.71 up Mm.1399 Gcm2 94710_g_at D88611 glial cells missing homolog 2 (Drosophila)6497 0.35828 1.30 down Mm.27801 Slc30a4 95571_at AF004100 solute carrier family 30 (zinc transporter), member 46498 0.35829 2.51 up Mm.5304 Gabra2 101215_at M86567 gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 26499 0.35838 1.46 down Mm.27218 Mrgx-pending 96633_s_at AA529583 MORF-related gene X6500 0.35838 1.20 down Mm.21634 Ube4b 93966_at AI849706 ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)6501 0.35847 1.33 down Mm.5935 AI317193 93240_f_at AI838094 expressed sequence AI3171936502 0.35849 1.28 up Mm.196037 Hoxb8 92915_s_at X13961 homeo box B86503 0.35852 1.54 up Mm.29564 Mmp2 161509_at AV145762 matrix metalloproteinase 26504 0.35866 1.92 up 101780_at X662856505 0.35867 1.45 up Mm.104919 Bcas2 97701_at AI181906 breast carcinoma amplified sequence 26506 0.35875 2.15 up Mm.174372 Cyp2d10 101287_s_at M24264 cytochrome P450, 2d106507 0.35878 1.33 up Mm.4190 Slc12a4 92450_at AF047339 solute carrier family 12, member 46508 0.35892 1.57 up Mm.29966 Ptbp2 160374_r_at AI119718 polypyrimidine tract binding protein 26509 0.35897 1.31 up Mm.196407 Igk-V21 94725_f_at X88903 immunoglobulin kappa chain variable 21 (V21)6510 0.35898 1.55 down Mm.3072 Sipa1 162007_i_at AV337065 signal-induced proliferation associated gene 16511 0.35900 1.76 up Mm.41171 Tnfsf9 92415_at L15435 tumor necrosis factor (ligand) superfamily, member 96512 0.35906 1.41 down Mm.44501 2500002G23Rik 92664_at AW050270 RIKEN cDNA 2500002G23 gene6513 0.35914 1.36 up Mm.55143 Dkk3 93188_at AJ243964 dickkopf homolog 3 (Xenopus laevis)6514 0.35921 1.25 up Mm.29138 Chordc1 160330_at AW122453 cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein6515 0.35925 1.84 down Mm.4161 Krt1-2 162214_r_at AV087860 keratin complex 1, acidic, gene 26516 0.35933 1.33 up Mm.28957 Peli1 94505_at AW124934 pellino 16517 0.35940 2.02 up 97560_at AF0374376518 0.35942 1.14 up Mm.182271 1300003G02Rik 94241_at AI837229 RIKEN cDNA 1300003G02 gene6519 0.35942 1.25 up Mm.10182 Gtf2h4 102039_at AI850881 general transcription factor II H, polypeptide 46520 0.35946 1.68 up Mm.196043 Idh3a 161652_r_at AV095915 isocitrate dehydrogenase 3 (NAD+) alpha6521 0.35955 1.33 down Mm.87279 Mef2a 93852_at AW045443 myocyte enhancer factor 2A6522 0.35977 1.62 up Mm.27918 5730434B08Rik 92413_at AI846986 RIKEN cDNA 5730434B08 gene6523 0.35991 1.26 up Mm.43786 Cox7c 99660_f_at X52940 cytochrome c oxidase, subunit VIIc6524 0.36002 1.62 up Mm.154890 Sars2-pending 161681_i_at AV160849 seryl-aminoacyl-tRNA synthetase 26525 0.36003 1.17 down Mm.28288 1110007I12Rik 104245_at AW124639 RIKEN cDNA 1110007I12 gene6526 0.36009 1.39 down Mm.30080 Eif3s4 96883_at U70733 eukaryotic translation initiation factor 3, subunit 4 (delta, 44 kDa)6527 0.36015 1.22 down Mm.43017 0610040D20Rik 99616_s_at AI842156 RIKEN cDNA 0610040D20 gene6528 0.36020 1.12 down Mm.29685 Dnajc8 95699_f_at AI848094 DnaJ (Hsp40) homolog, subfamily C, member 86529 0.36031 1.16 up Mm.29041 C85417 94530_at AI840376 expressed sequence C854176530 0.36063 1.41 up Mm.3786 Slc34a2 98994_at AF081499 solute carrier family 34 (sodium phosphate), member 26531 0.36066 2.97 up Mm.2019 Mrc1 103226_at Z11974 mannose receptor, C type 16532 0.36070 1.71 down Mm.212362 Mm.212362 97088_at AI481463 ESTs, Weakly similar to C53B4.2.p [Caenorhabditis elegans] [C.elegans]6533 0.36072 1.63 up Mm.554 Mcsp 100891_at M88463 mitochondrial capsule selenoprotein6534 0.36074 2.08 up Mm.20434 Klrg1 95320_at AF097357 killer cell lectin-like receptor subfamily G, member 16535 0.36076 1.52 up Mm.182692 Sh3glb1 103569_at AI842874 SH3-domain GRB2-like B1 (endophilin)6536 0.36080 1.46 up Mm.37835 Rpl7 161226_f_at AV259893 ribosomal protein L76537 0.36092 1.86 up Mm.215 Hoxb6 102579_f_at M11988 homeo box B66538 0.36092 1.69 up Mm.24762 Mm.24762 95931_at AI314706 ESTs6539 0.36093 1.30 up Mm.6710 Rock1 100980_at U58512 Rho-associated coiled-coil forming kinase 16540 0.36099 1.79 up Mm.28638 Sh3bgr 161935_r_at AV329249 SH3-binding domain glutamic acid-rich protein6541 0.36104 2.25 up Mm.29075 0710005K15Rik 94545_at AW123115 RIKEN cDNA 0710005K15 gene6542 0.36106 1.46 up Mm.57034 Fut4 99406_at U33457 fucosyltransferase 46543 0.36116 1.41 up Mm.196445 Traf5 103255_at D78141 Tnf receptor-associated factor 56544 0.36126 1.52 down Mm.25119 3230401D17Rik 160200_at AA816191 RIKEN cDNA 3230401D17 gene6545 0.36133 1.98 up Mm.2567 Elovl2 94393_r_at AI317360 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like6546 0.36146 1.97 up Mm.197620 Klra4 94776_f_at U10090 killer cell lectin-like receptor, subfamily A, member 46547 0.36152 1.37 up Mm.40620 9130415E20Rik 95020_at AI848868 RIKEN cDNA 9130415E20 gene6548 0.36157 1.31 down Mm.28424 Mm.28424 104246_at AI852340 ESTs, Moderately similar to T17285 hypothetical protein DKFZp434N0535.16549 0.36160 1.49 up Mm.29987 B230114J08Rik 161222_r_at AV256386 RIKEN cDNA B230114J08 gene6550 0.36169 1.35 up Mm.5697 Mm.5697 93203_f_at AW107463 ESTs6551 0.36180 1.12 up Mm.1418 Scn1b 161510_f_at AV151915 sodium channel, voltage-gated, type I, beta polypeptide6552 0.36183 1.30 up Mm.24662 S100a1 95453_f_at AF087687 S100 calcium binding protein A16553 0.36186 1.15 up Mm.30010 Arpc1b 96357_at AW212775 actin related protein 2/3 complex, subunit 1B (41 kDa)6554 0.36194 1.26 up Mm.30232 D9Bwg1455e 97928_at AW045278 DNA segment, Chr 9, Brigham & Women's Genetics 1455 expressed6555 0.36198 1.59 up Mm.24905 Mm.24905 95948_at C76370 ESTs6556 0.36199 1.31 down Mm.34562 Sart1 98449_at AB014721 squamous cell carcinoma antigen recognized by T-cells 16557 0.36210 1.66 up Mm.5791 C79122 99818_at C79122 expressed sequence C791226558 0.36212 1.37 down Mm.206889 AI414051 96563_at AI414051 expressed sequence AI4140516559 0.36213 1.26 up Mm.12950 Gdap10 94192_at Y17860 ganglioside-induced differentiation-associated-protein 106560 0.36214 1.72 down Mm.18775 2310007H09Rik 103403_at AW060833 RIKEN cDNA 2310007H09 gene6561 0.36217 1.21 down Mm.35833 Dci 98527_at Z14050 dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenyme A isom6562 0.36218 1.99 up Mm.28270 Cdc5l 95610_at AA636547 cell division cycle 5-like (S. pombe)6563 0.36229 1.43 up Mm.16347 Pnoc 102923_at U44027 prepronociceptin6564 0.36240 1.65 up Mm.89986 Avpr1b 96585_at AJ006691 arginine vasopressin receptor 1B6565 0.36243 1.47 up Mm.35840 Dtprp 98529_at AF011385 decidual/trophoblast prolactin-related protein6566 0.36260 1.30 up Mm.183042 Impa1 101498_at AF042730 inositol (myo)-1(or 4)-monophosphatase 16567 0.36266 1.87 up Mm.19214 Klk16 100719_f_at J03877 kallikrein 166568 0.36272 1.48 down Mm.1517 Sybl1 162113_r_at AV367027 synaptobrevin like 16569 0.36279 1.44 up Mm.26595 Zfp275 104002_at AI153693 Zinc finger protein 2756570 0.36285 1.53 up Mm.5007 Itga2 98834_at X75427 integrin alpha 2Page 73 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description6571 0.36285 1.38 up Mm.2141 Psme3 93803_at AB007139 proteaseome (prosome, macropain) 28 subunit, 36572 0.36287 1.85 up Mm.89194 Siat7a 100382_at Y11274 sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-beta-galactosyl-1,3)-N-ace6573 0.36293 1.35 down Mm.36907 AA409624 92281_at AA038443 expressed sequence AA4096246574 0.36297 1.40 up Mm.1269 Ppy 162464_f_at AV060302 pancreatic polypeptide6575 0.36307 1.40 down Mm.7329 Gamt 101408_at AF010499 guanidinoacetate methyltransferase6576 0.36325 1.33 up Mm.4658 Cdh3 100409_at X06340 cadherin 36577 0.36327 1.51 up Mm.57183 Mc3r 101822_at X74983 melanocortin 3 receptor6578 0.36327 1.32 down Mm.21655 R74783 103455_at AI591555 expressed sequence R747836579 0.36341 1.30 up Mm.25845 Adh4 103983_at AI046345 alcohol dehydrogenase 4 (class II), pi polypeptide6580 0.36344 1.85 down Mm.22702 Slc23a2 104387_at AF058318 solute carrier family 23 (nucleobase transporters), member 26581 0.36350 1.52 up Mm.2924 Pdgfra 160332_at AI840738 platelet derived growth factor receptor, alpha polypeptide6582 0.36353 1.40 up Mm.21414 Ccsd 161506_r_at AV131676 copper chaperone for superoxide dismutase6583 0.36357 1.36 down Mm.4839 Acvrl1 100450_r_at L48015 activin A receptor, type II-like 16584 0.36369 2.18 up Mm.12858 Eif4a1 162355_at AV160244 eukaryotic translation initiation factor 4A16585 0.36376 1.82 up Mm.25612 Tfpi2 94383_at D50586 tissue factor pathway inhibitor 26586 0.36383 1.25 up Mm.28216 Siva-pending 97828_at AF033115 Cd27 binding protein (Hindu God of destruction)6587 0.36395 1.56 up Mm.5612 C85189 100556_at AW121930 expressed sequence C851896588 0.36399 1.16 up Mm.6200 Col7a1 93383_at U32107 procollagen, type VII, alpha 16589 0.36410 1.71 up 101339_at AE0006656590 0.36417 1.15 down Mm.35812 Psmd8 98522_at AI839158 proteasome (prosome, macropain) 26S subunit, non-ATPase, 86591 0.36424 1.41 up Mm.193478 Klra7 97761_f_at U10094 killer cell lectin-like receptor, subfamily A, member 76592 0.36425 1.41 up Mm.89572 Mm.89572 97258_at AI841387 Mus musculus, clone MGC:7674 IMAGE:3496398, mRNA, complete cds6593 0.36430 1.67 up Mm.3058 Pik3r1 96592_at U50413 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)6594 0.36432 1.44 up Mm.396 Usp9x 99102_at U67874 ubiquitin specific protease 9, X chromosome6595 0.36432 1.39 up Mm.23880 3110052F15Rik 104567_at AI848526 RIKEN cDNA 3110052F15 gene6596 0.36435 1.22 down Mm.26537 D10Ertd438e 94435_at AI839117 DNA segment, Chr 10, ERATO Doi 438, expressed6597 0.36438 1.91 up Mm.30059 Macs 96865_at M60474 myristoylated alanine rich protein kinase C substrate6598 0.36439 1.49 up Mm.28719 2700038M07Rik 98946_at AF033186 RIKEN cDNA 2700038M07 gene6599 0.36461 1.74 up Mm.36563 Mm.36563 97191_at AA517032 ESTs6600 0.36470 1.37 down Mm.29094 Mm.29094 96787_at AA880891 Mus musculus, clone MGC:25863 IMAGE:4196269, mRNA, complete cds6601 0.36477 1.75 down Mm.27292 D6Wsu157e 161242_f_at AV272640 DNA segment, Chr 6, Wayne State University 157, expressed6602 0.36497 1.13 down Mm.34632 Suclg2 160428_at AF058956 succinate-Coenzyme A ligase, GDP-forming, beta subunit6603 0.36512 1.60 up Mm.196037 Hoxb8 96417_s_at M18399 homeo box B86604 0.36532 1.36 up Mm.42196 Np95 99564_at D87908 nuclear protein 956605 0.36536 1.35 down Mm.19974 0610012F07Rik 103595_at AW012359 RIKEN cDNA 0610012F07 gene6606 0.36542 1.43 up Mm.212785 Tcp10 100359_at M22602 t-complex protein-10 complex6607 0.36542 1.22 down Mm.21650 Pdcd5 93968_at AA870917 programmed cell death 56608 0.36543 2.03 up Mm.27126 AI606951 160997_at AI606951 expressed sequence AI6069516609 0.36554 1.64 up Mm.14614 Mm.14614 94749_f_at AF067062 Mus musculus clone L8 variable group of 2-cell-stage gene family mRNA, co6610 0.36570 1.39 up Mm.213024 Mm.213024 161917_i_at AV380429 EST, Highly similar to 1903270A phenylethanolamine N-methyltransferase [M6611 0.36571 1.34 down Mm.5028 Arix 92980_at X75014 aristaless homeobox gene homolog (Drosophila)6612 0.36576 1.27 up Mm.29700 2900010M23Rik 95707_at AA615853 RIKEN cDNA 2900010M23 gene6613 0.36593 1.51 up Mm.12808 Prkce 94161_at AF028009 protein kinase C, epsilon6614 0.36595 1.28 down Mm.29379 1810018M05Rik 160339_at AI850569 RIKEN cDNA 1810018M05 gene6615 0.36597 1.49 down Mm.26544 Hoxd9 103741_at X62669 homeo box D96616 0.36608 2.37 down Mm.3915 Mobp 99048_g_at U81317 myelin-associated oligodendrocytic basic protein6617 0.36618 1.50 up Mm.29157 Ugt2b5 96796_f_at X06358 UDP-glucuronosyltransferase 2 family, member 56618 0.36631 1.40 down Mm.23982 AU015179 104585_at AI316546 expressed sequence AU0151796619 0.36633 1.68 down Mm.24937 1500001M20Rik 162417_at AV322862 RIKEN cDNA 1500001M20 gene6620 0.36634 1.20 down Mm.28121 1110061A19Rik 160268_at AI847146 RIKEN cDNA 1110061A19 gene6621 0.36641 1.77 up Mm.57010 Art2a 99403_at X52991 ADP-ribosyltransferase 2a6622 0.36667 1.69 up Mm.304 Rb1 161858_f_at AV338260 retinoblastoma 16623 0.36669 1.43 up Mm.29674 Ptk2 161982_at AV233274 PTK2 protein tyrosine kinase 26624 0.36679 1.18 down Mm.2551 Sec22l1 103953_at U91538 SEC22 vesicle trafficking protein-like 1 (S. cerevisiae)6625 0.36687 1.61 down Mm.3390 Myo1b 98409_at L00923 myosin Ib6626 0.36699 1.16 down Mm.29834 0610008N23Rik 96264_at AW061235 RIKEN cDNA 0610008N23 gene6627 0.36701 1.14 down Mm.34456 2400003N08Rik 98070_at AI844794 RIKEN cDNA 2400003N08 gene6628 0.36709 1.66 up Mm.97570 Mm.97570 162282_f_at AV371866 ESTs6629 0.36718 1.20 down Mm.21537 1110018J12Rik 104058_at AW047528 RIKEN cDNA 1110018J12 gene6630 0.36719 2.00 down Mm.4497 Ptk6 98384_at U16805 protein tyrosine kinase 66631 0.36721 1.65 up Mm.2932 Cmkbr7 104443_at L31580 chemokine (C-C) receptor 76632 0.36724 1.41 up Mm.206653 Mm.206653 104402_at AA030469 ESTs6633 0.36731 1.37 down Mm.25783 1110051M20Rik 94400_at AI843094 RIKEN cDNA 1110051M20 gene6634 0.36736 1.99 up Mm.200428 AA407323 103502_at AA866768 expressed sequence AA4073236635 0.36736 1.49 up Mm.18041 Calm2 161133_at AV122577 calmodulin 26636 0.36737 1.69 down Mm.181969 Timp2 161515_i_at AV156389 tissue inhibitor of metalloproteinase 26637 0.36748 2.17 up Mm.56906 Gjb4 99373_at M91443 gap junction membrane channel protein beta 46638 0.36750 1.27 up Mm.27155 Dgcr6 161512_r_at AV153952 DiGeorge syndrome chromosome region 66639 0.36755 1.47 up Mm.15512 Kcnab2 102892_at U65592 potassium voltage-gated channel, shaker-related subfamily, beta member 26640 0.36756 1.22 down Mm.18161 Papss1 93298_at U34883 3'-phosphoadenosine 5'-phosphosulfate synthase 16641 0.36767 1.66 down Mm.4605 Tbx2 161146_r_at AV220470 T-box 26642 0.36770 1.66 down Mm.3093 Serpine2 97487_at X70296 serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activato6643 0.36788 1.53 up Mm.180108 Cacna1h 160953_at AF051947 calcium channel, voltage-dependent, T type, alpha 1H subunit6644 0.36795 1.27 down Mm.21331 4930451A13Rik 103901_at AW213777 RIKEN cDNA 4930451A13 gene6645 0.36795 1.69 up Mm.26791 Gnrhr 104012_at L28756 gonadotropin releasing hormone receptor6646 0.36796 1.25 up Mm.11285 AI836109 102350_at AI836109 expressed sequence AI8361096647 0.36799 1.25 down Mm.144420 0610038P07Rik 104248_at AW227650 RIKEN cDNA 0610038P07 gene6648 0.36804 1.42 up Mm.4141 Vldlr 160865_at L33417 very low density lipoprotein receptor6649 0.36816 1.25 up Mm.3414 Ptpn13 98424_at D83966 protein tyrosine phosphatase, non-receptor type 136650 0.36819 1.66 up Mm.1349 Il1r2 161689_f_at AV223216 interleukin 1 receptor, type II6651 0.36820 1.78 up Mm.29997 6030455P07Rik 96347_at AW106423 RIKEN cDNA 6030455P07 gene6652 0.36821 1.89 up Mm.8239 Apoc4 101463_at Z24722 apolipoprotein CIV6653 0.36824 2.27 up Mm.2137 Sin3b 93790_at L38622 transcriptional regulator, SIN3B (yeast)6654 0.36830 1.56 up Mm.4146 Pdgfrb 160867_at X04367 platelet derived growth factor receptor, beta polypeptide6655 0.36833 1.35 down Mm.29092 5730408C10Rik 94555_at AI845579 RIKEN cDNA 5730408C10 gene6656 0.36839 1.77 up Mm.4242 Mm.4242 101121_at AA517747 EST6657 0.36846 1.49 up Mm.5874 Mm.5874 99824_at C79764 ESTs6658 0.36866 1.52 up Mm.72173 Sgcg 101394_at AB024922 sarcoglycan, gamma (35kD dystrophin-associated glycoprotein)6659 0.36866 1.26 up Mm.33996 Mx1 98417_at M21038 myxovirus (influenza virus) resistance 16660 0.36881 1.67 up Mm.4665 Aebp1 100412_g_at AF053943 AE binding protein 1Page 74 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description6661 0.36884 1.39 up Mm.25109 C81268 96486_at C81257 expressed sequence C812686662 0.36886 1.93 up Mm.12916 Zfp54 102625_f_at AF080070 zinc finger protein 546663 0.36888 1.25 up Mm.88548 Mm.88548 161085_r_at AA682038 ESTs6664 0.36890 1.24 up Mm.3845 D6Ertd109e 160451_at D87691 DNA segment, Chr 6, ERATO Doi 109, expressed6665 0.36894 1.65 down Mm.2312 2600017J23Rik 103529_at AW125505 RIKEN cDNA 2600017J23 gene6666 0.36916 1.58 up Mm.24361 AI118078 95905_at AI118078 expressed sequence AI1180786667 0.36934 1.81 up Mm.21830 Ril-pending 162494_at AV146972 reversion induced LIM gene6668 0.36937 1.19 down Mm.2411 G3bp2-pending 94913_at U65313 Ras-GTPase-activating protein (GAP) SH3-domain binding protein 26669 0.36937 1.41 up Mm.51136 1110035J23Rik 94483_at AW060442 RIKEN cDNA 1110035J23 gene6670 0.36937 1.31 up Mm.4723 Sct 162163_at AV038238 secretin6671 0.36951 1.62 down Mm.20240 Ckmt2 162015_f_at AV250974 creatine kinase, mitochondrial 26672 0.36969 1.76 up Mm.57179 Ly6f 99437_at X70922 lymphocyte antigen 6 complex, locus F6673 0.36973 1.49 up Mm.5764 Mm.5764 101598_at C78889 ESTs6674 0.36985 1.32 down Mm.195848 Amd2 100324_g_at Z23077 S-adenosylmethionine decarboxylase 26675 0.36989 2.33 up Mm.117180 Cfi 99927_at U47810 complement component factor i6676 0.36994 1.72 up Mm.4895 Zyx 100143_at Y07711 zyxin6677 0.37021 1.37 up Mm.28020 Crsp3 95616_at AA674714 cofactor required for Sp1 transcriptional activation, subunit 3 (130kD)6678 0.37032 1.29 down Mm.143167 0610010J20Rik 160347_at AW125168 RIKEN cDNA 0610010J20 gene6679 0.37054 1.82 up Mm.4485 Rgl1 161260_f_at AV290142 ral guanine nucleotide dissociation stimulator,-like 16680 0.37065 1.28 up Mm.206768 Ero1l 97870_s_at AA798624 ERO1-like (S. cerevisiae)6681 0.37070 1.15 down Mm.182628 Rad21 94768_at D37790 RAD21 homolog (S. pombe)6682 0.37072 2.59 up Mm.27001 AI425994 162273_at AV365510 EST AI4259946683 0.37077 1.28 up Mm.86541 Ccr4 93908_f_at X16670 carbon catabolite repression 4 homolog (S. cerevisiae)6684 0.37079 1.27 down Mm.10124 Chkl 102027_s_at AA204010 choline kinase-like6685 0.37105 1.76 up Mm.381 Adfp 161443_r_at AV351846 adipose differentiation related protein6686 0.37105 1.36 down Mm.2082 Apod 93592_at X82648 apolipoprotein D6687 0.37114 1.58 up Mm.10096 Hcrt 94098_at AF019566 hypocretin6688 0.37118 1.98 up 161125_at X984566689 0.37126 1.18 down Mm.23693 2010320M17Rik 94863_r_at AI850000 RIKEN cDNA 2010320M17 gene6690 0.37132 1.76 down Mm.43510 D1Ertd5e 102127_at C76274 DNA segment, Chr 1, ERATO Doi 5, expressed6691 0.37141 1.50 up Mm.56941 Olfr15 98779_at AL078630 olfactory receptor 156692 0.37147 1.36 up Mm.27807 Mm.27807 160627_at AA738710 ESTs, Weakly similar to S56112 RNA helicase [M.musculus]6693 0.37165 1.12 up Mm.25059 jmj 94341_at D31967 jumonji6694 0.37166 1.23 down Mm.140508 Trim11 94021_at AW048336 tripartite motif protein 116695 0.37169 1.31 down Mm.25694 Fnbp2 96516_at AA960459 formin binding protein 26696 0.37174 1.20 up Mm.27787 0610009D16Rik 95565_at AI852873 RIKEN cDNA 0610009D16 gene6697 0.37177 2.28 up Mm.197422 Gsta2 101872_at J03958 glutathione S-transferase, alpha 2 (Yc2)6698 0.37197 1.18 down Mm.56337 Pafah1b1 100560_at U95116 platelet-activating factor acetylhydrolase, isoform 1b, beta1 subunit6699 0.37207 1.35 down Mm.153797 Bcl2 98869_g_at L31532 B-cell leukemia/lymphoma 26700 0.37210 1.22 down Mm.29855 Mm.29855 96272_at AI848471 Mus musculus tyrosine phosphatase LAR (Ptprf) mRNA, complete cds6701 0.37212 1.57 up Mm.1269 Ppy 94148_at M18208 pancreatic polypeptide6702 0.37234 1.35 up Mm.29798 Cd34 160358_at AI847784 CD34 antigen6703 0.37252 1.21 down Mm.28130 Pctk3 96128_at X69026 PCTAIRE-motif protein kinase 36704 0.37261 2.22 up Mm.116254 Msh3 162155_f_at AV336534 mutS homolog 3 (E. coli)6705 0.37266 1.19 down Mm.28842 Clcn3 94463_at X78874 chloride channel 36706 0.37267 1.45 up Mm.42096 Gsbs-pending 98293_g_at AF071562 G substrate6707 0.37268 1.36 down Mm.6813 Bmp4 93456_r_at L47480 bone morphogenetic protein 46708 0.37269 1.22 down Mm.23082 3110041O18Rik 95383_at AI415418 RIKEN cDNA 3110041O18 gene6709 0.37270 1.21 up Mm.213064 Mm.213064 161014_at AI595912 Mus musculus, clone MGC:19411 IMAGE:3483521, mRNA, complete cds6710 0.37277 1.17 up Mm.26242 Mm.26242 94422_at AI842938 ESTs, Highly similar to T00361 hypothetical protein KIAA0678 [H.sapiens]6711 0.37282 2.55 up Mm.6211 Amac1 161393_at AV260461 acyl-malonyl condensing enzyme6712 0.37284 1.76 up Mm.2544 Ms4a1 96509_at J05019 membrane-spanning 4-domains, subfamily A, member 16713 0.37284 1.69 up Mm.42516 C76472 102106_at C76472 expressed sequence C764726714 0.37293 1.33 up Mm.4300 Ccnc 99558_at U62638 cyclin C6715 0.37306 1.97 up Mm.25015 D2Ertd239e 95977_at C79214 DNA segment, Chr 2, ERATO Doi 239, expressed6716 0.37309 1.39 up Mm.32906 Pcsk6 101196_at D50060 proprotein convertase subtilisin/kexin type 66717 0.37313 1.40 up Mm.154915 Rps29 98523_at L31609 ribosomal protein S296718 0.37316 1.43 up Mm.20156 2610042F04Rik 103604_at AW231026 RIKEN cDNA 2610042F04 gene6719 0.37326 1.46 down Mm.28453 Mm.28453 96556_at C81463 ESTs, Highly similar to T46482 hypothetical protein DKFZp434A045.1 [H.sap6720 0.37332 1.71 up Mm.10331 Tnfaip1 92572_at AI509617 tumor necrosis factor, alpha-induced protein 1 (endothelial)6721 0.37337 1.71 up Mm.470 Irebf1-pending 96400_at M55290 interferon response element binding factor 16722 0.37354 1.33 down Mm.10174 1810004B07Rik 102036_at AW046757 RIKEN cDNA 1810004B07 gene6723 0.37358 1.26 up Mm.29087 2510009N07Rik 94551_at AI853061 RIKEN cDNA 2510009N07 gene6724 0.37378 2.36 up Mm.30133 Etohi6 96906_at AI837904 ethanol induced 66725 0.37387 1.60 up Mm.21144 C79407 103308_at AI450597 expressed sequence C794076726 0.37389 1.27 down Mm.25161 Sirt2 95502_at AI840267 sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisia6727 0.37416 1.33 down Mm.218761 Sfrs10 95791_s_at U14648 splicing factor, arginine/serine-rich 106728 0.37422 1.25 up Mm.24873 Nola1 104766_at AI851198 nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs)6729 0.37434 1.24 up Mm.182053 1810030E05Rik 95601_at AW125420 RIKEN cDNA 1810030E05 gene6730 0.37435 1.30 up Mm.18618 Gcat 160628_at AI849354 glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase)6731 0.37436 1.25 up Mm.24219 1810037I17Rik 95406_at AW125347 RIKEN cDNA 1810037I17 gene6732 0.37444 1.61 up Mm.4350 Es31 99941_at L11333 esterase 316733 0.37451 1.33 up Mm.6595 Map3k5 99855_at AB006787 mitogen activated protein kinase kinase kinase 56734 0.37465 1.19 up Mm.10076 Mrpl13 102019_at AA666635 mitochondrial ribosomal protein L136735 0.37481 1.48 up Mm.55092 Mm.55092 99356_r_at AI644566 ESTs6736 0.37487 1.79 down Mm.27453 D5Wsu31e 161453_r_at AV293460 DNA segment, Chr 5, Wayne State University 31, expressed6737 0.37492 1.29 down Mm.24156 Fbxo8 94917_at AI844932 f-box only protein 86738 0.37493 1.19 down Mm.121878 Tpm1 160532_at M22479 tropomyosin 1, alpha6739 0.37500 1.46 up Mm.20488 1110008K06Rik 161576_f_at AV281450 RIKEN cDNA 1110008K06 gene6740 0.37500 1.63 up Mm.4528 Lag3 98392_at X98113 lymphocyte-activation gene 36741 0.37501 1.29 up Mm.24763 Scoc 95467_at AW120746 short coiled coil protein6742 0.37507 1.37 down Mm.37672 Ikbke 92301_at AB016589 inhibitor of kappaB kinase epsilon6743 0.37516 1.42 up Mm.4194 AA511254 97775_at AI503257 expressed sequence AA5112546744 0.37519 1.23 down Mm.25648 2400004O09Rik 160991_at AI846893 RIKEN cDNA 2400004O09 gene6745 0.37520 4.26 up Mm.4159 Thbs1 160469_at M62470 thrombospondin 16746 0.37523 1.81 down Mm.196344 Clu 95286_at D14077 clusterin6747 0.37538 1.66 up Mm.3848 7420700M05Rik 92324_at AA823643 RIKEN cDNA 7420700M05 gene6748 0.37539 1.41 up Mm.4446 Gnaq 99981_at M55412 guanine nucleotide binding protein, alpha q polypeptide6749 0.37556 1.20 up Mm.6874 Surf1 98168_at M14689 surfeit gene 16750 0.37567 1.20 up Mm.29816 Pdcd6ip 95040_at AI840810 programmed cell death 6 interacting proteinPage 75 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description6751 0.37568 1.24 down Mm.26304 AU022220 94424_at AW048712 expressed sequence AU0222206752 0.37568 1.45 up Mm.213078 Fv4 103049_at M29211 Friend virus susceptibility 46753 0.37570 1.29 down Mm.28555 1200003C05Rik 160302_at AW046391 RIKEN cDNA 1200003C05 gene6754 0.37581 1.46 up Mm.200898 LOC55933 100996_at AF015811 putative lysophosphatidic acid acyltransferase6755 0.37590 1.36 up Mm.21882 Cd84 100914_at AA624599 CD84 antigen6756 0.37593 1.63 up Mm.626 Psme2 161938_r_at AV333841 proteasome (prosome, macropain) 28 subunit, beta6757 0.37606 1.29 down Mm.2223 Tcp1 94218_at M20130 t-complex protein 16758 0.37609 1.45 up Mm.179011 Vav2 92998_at U37017 Vav2 oncogene6759 0.37617 1.34 down Mm.12821 Atp4a 94163_at U17282 ATPase, H+/K+ transporting, alpha polypeptide6760 0.37623 1.33 down Mm.177991 0610010I12Rik 97268_i_at AI848699 RIKEN cDNA 0610010I12 gene6761 0.37623 1.35 up Mm.1268 Plp 92801_at M37335 proteolipid protein (myelin)6762 0.37635 1.65 up Mm.5020 Sema3a 98835_at D85028 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (se6763 0.37643 1.34 down Mm.203837 AI842544 104298_at AI842544 expressed sequence AI8425446764 0.37653 1.21 up Mm.41801 2610511E03Rik 99182_at AI846712 RIKEN cDNA 2610511E03 gene6765 0.37674 1.26 down Mm.28689 Tbrg1 98937_at AW049795 transforming growth factor beta regulated gene 16766 0.37690 1.47 up Mm.28362 AI326478 97577_f_at AF042086 expressed sequence AI3264786767 0.37703 1.37 down Mm.27062 3110031O14Rik 100356_at AW121051 RIKEN cDNA 3110031O14 gene6768 0.37706 1.38 up Mm.2209 Cd4 103931_at AC002397 CD4 antigen6769 0.37707 1.24 up Mm.31946 1810063B05Rik 97514_at AW046438 RIKEN cDNA 1810063B05 gene6770 0.37707 1.41 down Mm.4605 Tbx2 92705_at U15566 T-box 26771 0.37725 1.20 down Mm.21079 Pccb 160128_at AA882332 propionyl Coenzyme A carboxylase, beta polypeptide6772 0.37756 1.46 down Mm.30108 4921510D23Rik 96896_at AW214159 RIKEN cDNA 4921510D23 gene6773 0.37763 1.63 up Mm.35334 Rpgr 95550_at AJ238396 retinitis pigmentosa GTPase regulator6774 0.37776 1.73 up Mm.57005 Notch2 101342_at D32210 Notch gene homolog 2, (Drosophila)6775 0.37783 1.22 up Mm.28595 2410018C03Rik 96200_at AI838344 RIKEN cDNA 2410018C03 gene6776 0.37796 1.83 up Mm.83 R74903 93685_at AI843893 expressed sequence R749036777 0.37810 1.37 up Mm.4183 Plau 97772_at M17922 plasminogen activator, urokinase6778 0.37813 1.24 up Mm.29253 2310032N20Rik 95081_at AI840176 RIKEN cDNA 2310032N20 gene6779 0.37815 1.18 up Mm.36879 Cltb 98560_at AI849152 clathrin, light polypeptide (Lcb)6780 0.37820 1.39 up Mm.44242 2310020A21Rik 100043_f_at AI173973 RIKEN cDNA 2310020A21 gene6781 0.37834 1.73 up Mm.44245 Adcyap1r1 98362_s_at AW048431 adenylate cyclase activating polypeptide 1 receptor 16782 0.37835 1.31 down Mm.29090 4021401A16Rik 94554_at AW120965 RIKEN cDNA 4021401A16 gene6783 0.37840 1.83 up Mm.5349 1700018F16Rik 161065_at AI507039 RIKEN cDNA 1700018F16 gene6784 0.37842 1.93 up Mm.6238 Sox11 93669_f_at AW107922 SRY-box containing gene 116785 0.37844 1.49 up Mm.222 Trp53 104275_g_at AB021961 transformation related protein 536786 0.37848 1.55 up Mm.21414 Ccsd 162382_f_at AV248506 copper chaperone for superoxide dismutase6787 0.37850 1.96 up Mm.5035 Pax9 98838_at X84000 paired box gene 96788 0.37855 1.97 up Mm.196607 Eif5a 95697_at AI839906 eukaryotic translation initiation factor 5a6789 0.37861 1.73 up Mm.174372 Cyp2d10 98612_at M24263 cytochrome P450, 2d106790 0.37907 1.38 up 100389_at AF0212316791 0.37909 1.45 up Mm.10728 Mybpc3 160582_at AF059576 myosin binding protein C, cardiac6792 0.37910 1.34 down Mm.40998 Kpna6 92405_at AF020773 karyopherin (importin) alpha 66793 0.37914 1.25 down Mm.154387 Tkt 101964_at U05809 transketolase6794 0.37922 1.26 down Mm.30670 Spnr 103330_at AI838709 spermatid perinuclear RNA binding protein6795 0.37931 1.45 up Mm.8068 Erf 93671_at U58533 Est2 repressor factor6796 0.37939 1.22 up Mm.1158 Atp6n2 160960_at AA881202 ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic ac6797 0.37940 2.88 up Mm.10681 Osf2-pending 92593_at D13664 osteoblast specific factor 2 (fasciclin I-like)6798 0.37945 1.17 up Mm.10082 Hip2 92547_at AB011081 huntingtin interacting protein 26799 0.37949 1.30 up Mm.2547 Dad1 161655_at AV099898 defender against cell death 16800 0.37952 1.19 down Mm.16710 Impnb 93111_at D45836 importin beta6801 0.37955 1.40 down Mm.7310 3110079O15Rik 161928_at AV169008 RIKEN cDNA 3110079O15 gene6802 0.37956 1.13 down Mm.25941 2700094L05Rik 94410_f_at AA611413 RIKEN cDNA 2700094L05 gene6803 0.37966 1.76 up Mm.56993 Gzmk 99398_at AF011446 granzyme K6804 0.37978 1.33 up Mm.658 Slc25a5 100617_at U10404 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocato6805 0.37978 1.12 down Mm.28883 Peci 94485_at AI840013 peroxisomal delta3, delta2-enoyl-Coenzyme A isomerase6806 0.37984 1.37 down Mm.1860 Pitpnm 103376_s_at AF006467 phosphatidylinositol membrane-associated6807 0.37990 1.57 down Mm.27913 2310032M22Rik 104218_s_at AI507524 RIKEN cDNA 2310032M22 gene6808 0.37996 1.61 up Mm.42578 Rpl13 161289_at AV302606 ribosomal protein L136809 0.38022 1.27 down Mm.29999 C79125 97422_at AW048882 expressed sequence C791256810 0.38027 1.28 down Mm.29475 2810052M02Rik 95152_g_at AW061307 RIKEN cDNA 2810052M02 gene6811 0.38031 1.41 down Mm.142731 Reg1 160213_at D14010 regenerating islet-derived 16812 0.38036 1.37 down Mm.4355 Uchrp 99639_at D84096 ubiquintin c-terminal hydrolase related polypeptide6813 0.38038 2.36 up Mm.87759 Enah 93864_s_at U72521 enabled homolog (Drosophila)6814 0.38077 1.31 up Mm.1426 Rgs14 102711_at U85055 regulator of G-protein signaling 146815 0.38082 1.65 up Mm.41931 Mfap5-pending 99517_at AA832724 microfibrillar associated protein 56816 0.38091 1.51 up Mm.4639 Cebpd 160894_at X61800 CCAAT/enhancer binding protein (C/EBP), delta6817 0.38106 1.61 up Mm.153999 Prlpf 162303_f_at AV035923 prolactin-like protein F6818 0.38115 1.37 down Mm.30114 Als2 96900_at AW125480 amyotrophic lateral sclerosis 2 (juvenile) homolog (human)6819 0.38117 1.29 up Mm.28726 C77032 98948_at AI785289 EST C770326820 0.38123 1.32 down Mm.42253 Slc22a5 98322_at AB015800 solute carrier family 22 (organic cation transporter), member 56821 0.38134 1.37 up Mm.29098 AU015645 161594_f_at AV291935 expressed sequence AU0156456822 0.38138 1.15 up Mm.22360 1200016D08Rik 94244_at AW123807 RIKEN cDNA 1200016D08 gene6823 0.38144 1.22 up Mm.4619 Msh2 162009_f_at AV246753 mutS homolog 2 (E. coli)6824 0.38145 1.87 up Mm.42036 Slc7a11 101713_at AB022345 solute carrier family 7 (cationic amino acid transporter, y+ system), member6825 0.38154 1.44 up Mm.38889 Rab17 92329_at X70804 RAB17, member RAS oncogene family6826 0.38159 1.26 down Mm.23173 2610100K07Rik 104532_at AI852126 RIKEN cDNA 2610100K07 gene6827 0.38170 1.28 down Mm.1167 Junb 102363_r_at U20735 Jun-B oncogene6828 0.38176 2.04 up Mm.204204 AA517841 95248_at AA517841 expressed sequence AA5178416829 0.38187 1.57 up Mm.56991 Galnt4 101333_at U73819 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltra6830 0.38200 1.98 up Mm.981 Mm.981 101952_at AI019095 Mus musculus C21orf18 mRNA, complete cds6831 0.38205 1.39 up Mm.2627 Xrcc5 96063_at X66323 X-ray repair complementing defective repair in Chinese hamster cells 56832 0.38207 1.17 down Mm.27895 AU040105 95591_at AI843335 expressed sequence AU0401056833 0.38207 1.70 down Mm.196085 Igh-4 101871_f_at X88902 immunoglobulin heavy chain 4 (serum IgG1)6834 0.38217 1.38 up Mm.219670 Mm.219670 92843_r_at AW046013 Mus musculus, Similar to eukaryotic translation initiation factor 4 gamma, 1,6835 0.38220 1.30 up Mm.27063 Trip6 94948_at AF097511 thyroid hormone receptor interactor 66836 0.38227 1.81 up Mm.17336 Hemt1 102949_g_at AJ242830 hematopoietic cell transcript 16837 0.38238 1.39 up Mm.201606 AI325109 100614_at X04405 expressed sequence AI3251096838 0.38252 1.19 up Mm.25703 D3Ertd330e 94395_at AI194254 DNA segment, Chr 3, ERATO Doi 330, expressed6839 0.38253 1.13 down Mm.2154 Mxi1 160138_at L38822 Max interacting protein 16840 0.38255 1.58 up Mm.21938 Rps20 94039_at AW046100 ribosomal protein S20Page 76 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description6841 0.38265 1.33 down Mm.89191 Ptprd 93485_at AI844911 protein tyrosine phosphatase, receptor type, D6842 0.38266 1.20 up Mm.37210 Ap1g1 103242_at AW123834 adaptor protein complex AP-1, gamma 1 subunit6843 0.38271 1.22 down Mm.29820 Bnip3l 96255_at AF067395 BCL2/adenovirus E1B 19 kDa-interacting protein 3-like6844 0.38274 1.64 up Mm.182067 Inpp5e 96848_at AW120756 inositol polyphosphate-5-phosphatase, 72 kDa6845 0.38298 1.56 down Mm.1273 Rarg 102419_at M34476 retinoic acid receptor, gamma6846 0.38304 1.20 up Mm.28750 Utx 102222_at AJ002730 ubiquitously transcribed tetratricopeptide repeat gene, X chromosome6847 0.38307 1.42 up Mm.196388 5830450F21Rik 160566_at AW121166 RIKEN cDNA 5830450F21 gene6848 0.38315 1.30 down Mm.22511 2310004I24Rik 104334_at AW060314 RIKEN cDNA 2310004I24 gene6849 0.38324 1.35 down Mm.15701 Trim28 93071_at X99644 tripartite motif protein 286850 0.38324 1.22 up Mm.12459 AW549277 92787_at AI845902 expressed sequence AW5492776851 0.38332 1.23 down Mm.27707 AU014660 160242_at AW121453 expressed sequence AU0146606852 0.38333 1.47 up Mm.10 Srm 92540_f_at Z67748 spermidine synthase6853 0.38336 1.22 down Mm.29864 Arpc5 96277_at AI850118 actin related protein 2/3 complex, subunit 5 (165 kDa)6854 0.38336 1.45 up Mm.29874 Myadm 96285_at AJ001616 myeloid-associated differentiation marker6855 0.38360 1.39 up Mm.2135 Folr1 162302_f_at AV035020 folate receptor 1 (adult)6856 0.38364 1.83 up Mm.3258 Plfr 98023_r_at K03237 proliferin related protein6857 0.38372 1.45 up Mm.3979 Mm.3979 102122_f_at AI323533 Mus musculus, Similar to ubiquitin-like 4, clone MGC:19132 IMAGE:42156996858 0.38376 1.32 up Mm.14109 H2-T3 102692_s_at D86082 histocompatibility 2, T region locus 36859 0.38380 1.15 down Mm.998 Psen1 102201_s_at L42177 presenilin 16860 0.38381 1.48 up Mm.7580 H2ls 101433_at AF010452 histocompatibility-2 complex class 1-like sequence6861 0.38399 1.55 down Mm.24276 C1r 161571_f_at AV239653 complement component 1, r subcomponent6862 0.38403 1.18 up Mm.4631 2310079H06Rik 161044_at AA727730 RIKEN cDNA 2310079H06 gene6863 0.38405 1.22 up Mm.27769 Mm.27769 97224_at AI851394 ESTs, Moderately similar to JC4899 proline rich protein - rat [R.norvegicus]6864 0.38411 1.76 up Mm.203391 AW229127 95902_at AW229127 expressed sequence AW2291276865 0.38421 1.37 up Mm.5011 Zfp37 92974_at X52533 zinc finger protein 376866 0.38425 1.86 up Mm.153729 2210010C04Rik 101337_at AE000663 RIKEN cDNA 2210010C04 gene6867 0.38433 1.74 down Mm.5409 Mm.5409 93181_r_at AW048354 ESTs6868 0.38437 1.30 up Mm.29116 Mm.29116 96791_at AW047875 ESTs6869 0.38438 1.45 up 96993_at U568376870 0.38440 1.63 up Mm.140988 Aldh1a3 98372_at AW050387 aldehyde dehydrogenase family 1, subfamily A36871 0.38464 1.40 up Mm.1482 Kcnj8 102849_at D88159 potassium inwardly-rectifying channel, subfamily J, member 86872 0.38466 3.72 down Mm.100276 Rdh6 102013_at AF030513 retinol dehydrogenase type 66873 0.38469 1.37 up Mm.23662 Sema6c 160700_i_at AB013729 sema domain, transmembrane domain (TM), and cytoplasmic domain, (sema6874 0.38486 1.40 up Mm.3102 Tal1 97973_at U01530 T-cell acute lymphocytic leukemia 16875 0.38497 1.31 up Mm.25613 Ier3 94384_at X67644 immediate early response 36876 0.38503 2.03 up Mm.4967 Itgam 98828_at X07640 integrin alpha M6877 0.38521 1.65 down Mm.57042 Nmbr 101726_at AB010281 neuromedin B receptor6878 0.38532 1.16 down Mm.29989 1110018L13Rik 96341_at AI849280 RIKEN cDNA 1110018L13 gene6879 0.38549 1.65 up Mm.2388 AI852661 95397_at AI852661 expressed sequence AI8526616880 0.38563 1.27 up Mm.14707 Mm.14707 102841_at AA623483 ESTs, Moderately similar to ubiquitin A-52 residue ribosomal protein fusion6881 0.38564 1.59 down Mm.5243 Oprd1 99332_at L11064 opioid receptor, delta 16882 0.38583 1.73 up Mm.206869 AI854265 97752_at AI854265 expressed sequence AI8542656883 0.38592 1.71 up Mm.18530 Ifi203 93321_at AF022371 interferon activated gene 2036884 0.38596 1.76 up Mm.172931 C78891 98598_at C78891 expressed sequence C788916885 0.38598 1.17 up Mm.28606 2310079C17Rik 98914_at AI853634 RIKEN cDNA 2310079C17 gene6886 0.38600 1.22 down Mm.117037 Pi4k2a-pending 160307_at AW121695 phosphatidylinositol 4-kinase type 2 alpha6887 0.38610 1.58 up Mm.68992 AV103077 93462_at AA168418 expressed sequence AV1030776888 0.38629 1.59 up Mm.154195 2810417D08Rik 93436_i_at AI850509 RIKEN cDNA 2810417D08 gene6889 0.38631 1.31 up Mm.12193 Mm.12193 102387_at AA799042 Mus musculus, Similar to 60S ribosomal protein L30 isolog, clone MGC:67356890 0.38645 1.73 up Mm.3535 Nr2c2 98479_f_at U32939 nuclear receptor subfamily 2, group C, member 26891 0.38653 1.35 up Mm.20440 Htr4 95322_g_at Y09588 5 hydroxytryptamine (serotonin) receptor 46892 0.38655 1.24 down Mm.28816 AI428238 96239_at AA815503 expressed sequence AI4282386893 0.38696 1.31 up Mm.9474 Dermo1 160939_at U36384 dermis expressed 16894 0.38728 1.30 up Mm.196220 Eif2a 94253_at AW061243 eukaryotic translation initiation factor 2A6895 0.38729 1.53 up Mm.2093 Sna 103830_at M95604 snail homolog, (Drosophila)6896 0.38736 1.71 up Mm.24035 D16Ertd480e 161266_r_at AV315320 DNA segment, Chr 16, ERATO Doi 480, expressed6897 0.38746 1.52 up Mm.4800 Prdm1 92904_at U08185 PR domain containing 1, with ZNF domain6898 0.38750 1.56 down Mm.24750 Pr-pending 95464_at AI048265 voltage-dependent calcium channel gamma subunit-like protein6899 0.38773 1.39 down Mm.7861 Hnrpdl 96083_s_at AI226368 heterogeneous nuclear ribonucleoprotein D-like6900 0.38790 1.38 down Mm.20942 Mg29 103838_at AB010144 mitsugumin 296901 0.38797 1.57 up Mm.93826 Mm.93826 161942_f_at AV337197 ESTs6902 0.38810 1.12 down Mm.2400 Gpx4 94897_at D87896 glutathione peroxidase 46903 0.38817 1.58 up Mm.48757 Fes 92188_s_at X12616 feline sarcoma oncogene6904 0.38819 1.27 down Mm.41454 Cenpb 99486_at X55038 centromere autoantigen B6905 0.38826 1.54 up Mm.10099 Nptx2 94099_at AF049124 neuronal pentraxin 26906 0.38834 1.42 up Mm.1499 Pkib 102858_at L02241 protein kinase inhibitor beta, cAMP dependent, <strong>test</strong>is specific6907 0.38834 1.17 up Mm.2454 Sh3d19 103755_at D89677 SH3 domain protein D196908 0.38853 1.41 up Mm.215120 Ifi205 94224_s_at M74123 interferon activated gene 2056909 0.38855 1.73 down Mm.1452 Cd86 102830_at L25606 CD86 antigen6910 0.38859 1.32 up Mm.34104 Ncoa6ip 93911_at AI315090 nuclear receptor coactivator 6 interacting protein6911 0.38861 2.75 up Mm.200928 C79645 161797_r_at AV368612 expressed sequence C796456912 0.38877 1.46 up Mm.42162 Sox7 92487_at AB023419 SRY-box containing gene 76913 0.38902 1.35 down Mm.207 Hoxb5 103666_at M26283 homeo box B56914 0.38903 1.75 up Mm.4921 Gria2 92946_f_at L32372 glutamate receptor, ionotropic, AMPA2 (alpha 2)6915 0.38918 1.30 down Mm.18728 AI316828 161749_r_at AV324433 expressed sequence AI3168286916 0.38939 1.09 down Mm.28170 Rela 97813_at M61909 v-rel reticuloendotheliosis viral oncogene homolog A, (avian)6917 0.38952 1.60 up Mm.6834 Ifnar2 101014_at Y09864 interferon (alpha and beta) receptor 26918 0.38953 1.54 up Mm.24038 Gbp2 104597_at AJ007970 guanylate nucleotide binding protein 26919 0.38955 1.70 up Mm.24432 Mm.24432 95909_at AI662793 ESTs6920 0.38970 1.55 up Mm.100720 9130023P14Rik 92277_at AW125858 RIKEN cDNA 9130023P14 gene6921 0.38976 1.19 down Mm.23885 C76904 103681_at AW049274 expressed sequence C769046922 0.38977 1.35 down Mm.68887 Lamb2 101359_at U43541 laminin, beta 26923 0.38979 1.42 up Mm.28996 Timm10 96760_at AW122428 translocase of inner mitochondrial membrane 10 homolog (yeast)6924 0.38981 1.63 up Mm.46299 Gngt2 160893_at AI882325 guanine nucleotide binding protein (G protein), gamma transducing activity p6925 0.38986 1.60 down Mm.2735 Cubn 94999_at AJ010338 cubilin (intrinsic factor-cobalamin receptor)6926 0.38990 1.46 up Mm.14775 Mm.14775 94114_at Y12290 Mus musculus, H4 histone family, member A, clone MGC:30488 IMAGE:4206927 0.38993 1.29 up Mm.168789 Cdkn1c 95471_at U22399 cyclin-dependent kinase inhibitor 1C (P57)6928 0.38995 1.25 up Mm.934 Serpinf2 101928_at Z36774 serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigme6929 0.39004 1.22 down Mm.24220 2310003F16Rik 95408_at AW124487 RIKEN cDNA 2310003F16 gene6930 0.39030 1.23 down Mm.8211 Pja1 101461_f_at U06944 praja1, RING-H2 motif containingPage 77 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description6931 0.39033 1.53 up Mm.21408 4631426H08Rik 93801_at AA763275 RIKEN cDNA 4631426H08 gene6932 0.39040 1.33 up Mm.143833 Klk21 101289_f_at M17979 kallikrein 216933 0.39041 1.12 down Mm.200783 AU014939 96723_f_at AW122911 expressed sequence AU0149396934 0.39051 1.29 up Mm.30262 Klf5 97937_at AA611766 Kruppel-like factor 56935 0.39052 1.27 down Mm.27142 2610306D21Rik 94954_at AI846628 RIKEN cDNA 2610306D21 gene6936 0.39056 1.31 up Mm.86686 H2-M10.1 100304_at AI449957 histocompatibility 2, M region locus 10.16937 0.39057 1.33 up Mm.31726 AI838661 160831_at AI838661 expressed sequence AI8386616938 0.39072 1.64 up Mm.39095 Ntn1 97728_at U65418 netrin 16939 0.39075 1.59 up Mm.20355 Wnt4 103238_at M89797 wingless-related MMTV integration site 46940 0.39097 1.76 up Mm.8534 Egfr 101840_at L06864 epidermal growth factor receptor6941 0.39121 1.18 up Mm.726 Bsg 101078_at Y16258 basigin6942 0.39134 1.26 up Mm.12441 AU014645 102400_at AW125118 expressed sequence AU0146456943 0.39135 1.48 up Mm.4662 Irg1 98773_s_at AI323667 immunoresponsive gene 16944 0.39143 1.51 up Mm.34644 Zfp312 92229_at AW047710 zinc finger protein 3126945 0.39166 1.52 up Mm.56951 Fpr1 99387_at L22181 formyl peptide receptor 16946 0.39190 1.80 down Mm.56950 Mm.56950 101307_at Y10221 Mus musculus, Similar to cytochrome P450, 4a10, clone MGC:25972 IMAGE6947 0.39195 1.37 up Mm.24990 C78282 95971_at C78282 expressed sequence C782826948 0.39213 1.53 up Mm.925 Tfdp1 97565_r_at AF043939 transcription factor Dp 16949 0.39231 1.20 up Mm.145384 1810031K02Rik 96219_at AI850357 RIKEN cDNA 1810031K02 gene6950 0.39245 1.45 up Mm.24842 2310046B19Rik 104761_at AA612450 RIKEN cDNA 2310046B19 gene6951 0.39271 1.41 up Mm.88406 Itpr2 94565_at AB012393 inositol 1,4,5-triphosphate receptor 26952 0.39291 1.40 down Mm.57036 Omp 99407_at U02557 olfactory marker protein6953 0.39295 1.45 down Mm.5820 Msc 93234_at AF087035 musculin6954 0.39303 1.46 down Mm.42049 Papolb 161033_at AB030729 poly (A) polymerase beta (<strong>test</strong>is specific)6955 0.39317 1.93 up Mm.23288 Eomes 93880_at AB031037 eomesodermin homolog (Xenopus laevis)6956 0.39328 1.43 up Mm.318 2010107E04Rik 97512_at AW226650 RIKEN cDNA 2010107E04 gene6957 0.39330 1.57 up Mm.116700 Crlf1 98389_at AW046428 cytokine receptor-like factor 16958 0.39354 1.88 up Mm.4806 Epha7 92906_at X79083 Eph receptor A76959 0.39361 1.54 up Mm.1799 AW413091 102961_at AI118358 expressed sequence AW4130916960 0.39377 1.38 up Mm.70066 Dhh 99861_at X76292 desert hedgehog homolog, (Drosophila)6961 0.39386 2.36 up Mm.135039 Mm.135039 93166_at AI448307 ESTs6962 0.39391 1.40 up Mm.28843 Mafg 96147_at AW125070 v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)6963 0.39394 1.38 up 101290_at M148726964 0.39397 1.65 up Mm.3010 2810405F18Rik 97434_at AI646411 RIKEN cDNA 2810405F18 gene6965 0.39406 1.58 up Mm.1249 Lamc1 102404_at J03484 laminin, gamma 16966 0.39415 1.30 down Mm.20000 Ddx9 103598_at U91922 DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 96967 0.39433 1.81 up Mm.997 Il12b 100779_at M86671 interleukin 12b6968 0.39445 1.22 down Mm.196479 1810030E20Rik 96059_at AA823336 RIKEN cDNA 1810030E20 gene6969 0.39446 2.56 down Mm.30313 Ncam2 96581_at AF001286 neural cell adhesion molecule 26970 0.39463 1.60 up Mm.25608 1110057K04Rik 161190_r_at AV240195 RIKEN cDNA 1110057K04 gene6971 0.39476 1.33 down Mm.42193 Spin 99528_at AW122015 spindlin6972 0.39481 1.84 up Mm.139748 Klra9 94779_f_at U34891 killer cell lectin-like receptor subfamily A, member 96973 0.39488 1.67 down Mm.31927 Tm4sf9-pending 92426_at AI877157 transmembrane 4 superfamily member 96974 0.39490 2.36 up Mm.5175 Fert2 99321_at U76762 fer (fms/fps related) protein kinase, <strong>test</strong>is specific 26975 0.39510 1.29 up Mm.20176 Cryga 103609_at K02587 crystallin, gamma A6976 0.39516 1.36 down Mm.5077 Msi1h 98851_at D49654 Musashi homolog 1(Drosophila)6977 0.39532 1.68 up Mm.643 Rps15 100602_at M33330 ribosomal protein S156978 0.39536 1.35 down Mm.5092 Pla2g1br 98853_at D30779 phospholipase A2, group IB, pancreas, receptor6979 0.39555 1.17 down Mm.22596 Tstap35b 162500_f_at AV171573 tissue specific transplantation antigen P35B6980 0.39557 1.43 down Mm.23808 D12Wsu95e 104558_at AA867123 DNA segment, Chr 12, Wayne State University 95, expressed6981 0.39581 1.29 up Mm.727 Tbx6 93611_at U57331 T-box 66982 0.39599 1.32 up Mm.170023 Mm.170023 103078_at AA881018 Mus musculus, clone MGC:25977 IMAGE:4241375, mRNA, complete cds6983 0.39622 1.24 down Mm.23222 Gs2na-pending 100878_at AW124985 nuclear autoantigen6984 0.39624 1.56 up Mm.22789 Mm.22789 95371_g_at AI413435 ESTs, Highly similar to CAD4 MOUSE RETINAL-CADHERIN PRECURSOR6985 0.39630 1.23 down Mm.21505 Cars 104048_at AI848732 cysteinyl-tRNA synthetase6986 0.39642 1.29 down Mm.3254 Mm.3254 161019_at W41560 ESTs, Weakly similar to zinc finger protein 105 [M.musculus]6987 0.39659 1.79 down Mm.5046 Ptprj 92984_g_at D49393 protein tyrosine phosphatase, receptor type, J6988 0.39664 1.34 up Mm.501 Abt1-pending 160898_at AB021860 activator of basal transcription6989 0.39673 1.24 down Mm.28917 1810045K17Rik 94931_at AI851104 RIKEN cDNA 1810045K17 gene6990 0.39702 1.32 up Mm.28827 AI463271 96722_at AA647555 expressed sequence AI4632716991 0.39713 1.68 down Mm.27035 Qscn6 96601_at AW045751 quiescin Q66992 0.39718 1.18 down Mm.6766 5031439A09Rik 101001_at AI647612 RIKEN cDNA 5031439A09 gene6993 0.39719 1.32 up Mm.20294 Sps2 93557_at U43285 selenophosphate synthetase 26994 0.39720 1.69 down Mm.2961 Tgm3 96566_at L10385 transglutaminase 3, E polypeptide6995 0.39720 1.22 up Mm.28859 Gnai1 104412_at AI153412 guanine nucleotide binding protein, alpha inhibiting 16996 0.39721 1.33 up Mm.734 Nras 94362_at AI843682 neuroblastoma ras oncogene6997 0.39737 1.92 up Mm.153729 2210010C04Rik 99400_at AE000663 RIKEN cDNA 2210010C04 gene6998 0.39738 1.44 up Mm.7053 Mm.7053 162017_at AV252577 ESTs6999 0.39741 1.71 up Mm.7459 Cyp4a14 101103_at Y11638 cytochrome P450, 4a147000 0.39745 1.18 up Mm.21475 C79874 103442_at AI843399 expressed sequence C798747001 0.39757 1.99 up Mm.378 Htr2c 97692_at M63685 5-hydroxytryptamine (serotonin) receptor 2C7002 0.39762 1.39 down Mm.25455 Mm.25455 160990_r_at AA170696 Mus musculus adult male <strong>test</strong>is cDNA, RIKEN full-length enriched library, clo7003 0.39776 1.63 up Mm.42197 Psmb1 161923_at AV143146 proteasome (prosome, macropain) subunit, beta type 17004 0.39777 1.26 down Mm.26772 2610207I16Rik 96095_i_at AI648018 RIKEN cDNA 2610207I16 gene7005 0.39783 1.21 down Mm.495 1200006I17Rik 100473_at AI851750 RIKEN cDNA 1200006I17 gene7006 0.39803 1.78 up Mm.157929 Mm.157929 102142_r_at AW046850 ESTs, Weakly similar to PBAS MOUSE PROBASIN PRECURSOR [M.muscu7007 0.39821 1.56 up Mm.28068 Diap3 95628_at AF094519 diaphanous homolog 3 (Drosophila)7008 0.39826 1.13 up Mm.200828 AA960140 104467_at AA763004 expressed sequence AA9601407009 0.39827 1.52 up Mm.42202 R-spondin 98312_at AB016768 thrombospondin type 1 domain7010 0.39836 1.62 up Mm.24183 Tagln3 160185_at AB031291 transgelin 37011 0.39852 1.56 up Mm.3819 Col12a1 92314_at U25652 procollagen, type XII, alpha 17012 0.39854 1.49 up Mm.15819 Cd68 103016_s_at X68273 CD68 antigen7013 0.39856 1.23 up Mm.20848 Rfxank 103801_at AF094761 regulatory factor X-associated ankyrin-containing protein7014 0.39859 1.37 up Mm.28021 AW228608 160261_i_at AI849416 expressed sequence AW2286087015 0.39875 1.25 down Mm.28598 Jak1 98911_at AI837528 Janus kinase 17016 0.39880 1.81 up Mm.8027 Trrp6 99909_at U49069 transient receptor protein 67017 0.39890 1.29 up Mm.22724 Plaa 160169_at AI851407 phospholipase A2, activating protein7018 0.39893 1.18 up Mm.82064 1110061L23Rik 96621_at AW048608 RIKEN cDNA 1110061L23 gene7019 0.39894 1.36 up Mm.4573 Frat1 92695_at U58974 frequently rearranged in advanced T-cell lymphomas7020 0.39915 1.17 down Mm.27444 1810034K18Rik 160743_at AI844222 RIKEN cDNA 1810034K18 genePage 78 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description7021 0.39915 1.33 up Mm.14812 Zfp51 102872_f_at X74855 zinc finger protein 517022 0.39919 1.81 up Mm.3943 Thpo 97734_at L34169 thrombopoietin7023 0.39927 1.53 down Mm.87720 Arfrp1 101866_at AW060486 ADP-ribosylation factor related protein 17024 0.39932 1.40 up Mm.88078 Es1 101537_at AF034435 esterase 17025 0.39941 1.28 down Mm.687 Arhb 101030_at X99963 ras homolog B (RhoB)7026 0.39945 1.53 down Mm.1103 2010003O02Rik 161660_r_at AV089517 RIKEN cDNA 2010003O02 gene7027 0.39968 1.27 down Mm.202771 AI507533 94380_at AI852581 expressed sequence AI5075337028 0.39978 1.44 up Mm.20858 Gtse1 103270_at AJ222580 G two S phase expressed protein 17029 0.39992 1.17 up Mm.24789 5930415H02Rik 95470_at AI846025 RIKEN cDNA 5930415H02 gene7030 0.39994 2.22 up Mm.14100 Scn9a 100670_at L42338 sodium channel, voltage-gated, type IX, alpha polypeptide7031 0.39995 1.39 up Mm.6667 1210002E11Rik 162377_f_at AV245111 RIKEN cDNA 1210002E11 gene7032 0.40012 1.18 up Mm.45683 1500034E06Rik 97271_at AI845593 RIKEN cDNA 1500034E06 gene7033 0.40012 1.89 up Mm.5584 Mm.5584 161068_at AW123574 ESTs7034 0.40024 1.13 up Mm.1886 Refbp1 160633_at U89876 RNA and export factor binding protein 17035 0.40040 1.25 up Mm.153481 Canx 94886_at L18888 calnexin7036 0.40041 1.15 down Mm.15243 Clpp 93048_at AJ005253 caseinolytic protease, ATP-dependent, proteolytic subunit homolog (E. coli)7037 0.40051 1.22 down Mm.15811 Bcl6 103015_at U41465 B-cell leukemia/lymphoma 67038 0.40053 1.46 down Mm.27047 Mm.27047 104032_at AI850087 ESTs, Weakly similar to A54602 microtubule-associated serine/threonine pro7039 0.40074 1.22 down Mm.28280 Renbp 96154_at AA600645 renin binding protein7040 0.40093 1.72 up Mm.34808 Krtap5-4 92240_at AA739024 keratin associated protein 5-47041 0.40100 1.39 down Mm.34570 Rpo1-3 98082_at D86609 RNA polymerase 1-3 (16 kDa subunit)7042 0.40102 1.11 down Mm.29032 D10Ertd214e 94526_at AI848453 DNA segment, Chr 10, ERATO Doi 214, expressed7043 0.40110 1.97 up Mm.1948 Tctex1 162241_r_at AV165145 t-complex <strong>test</strong>is expressed 17044 0.40140 1.46 up Mm.42126 Gprk7 92473_at Y11092 G protein-coupled receptor kinase 77045 0.40144 1.58 up Mm.219672 Mtmr1 103264_at AF073997 myotubularin related protein 17046 0.40154 1.78 down Mm.42086 Mm.42086 102079_at AF069744 Mus musculus Aip1 mRNA, complete cds7047 0.40158 1.27 up Mm.42035 Sema4f 92460_at AB022316 sema domain, immunoglobulin domain (Ig), TM domain, and short cytoplasm7048 0.40162 1.58 up Mm.1433 Npy2r 100703_at D86238 neuropeptide Y receptor Y27049 0.40199 1.21 down Mm.196396 Tuba1 100343_f_at M28729 tubulin alpha 17050 0.40206 1.22 up Mm.18418 Mapre1 93306_at U51196 microtubule-associated protein, RP/EB family, member 17051 0.40211 1.21 down Mm.22700 Gtf2h1 94812_at AA684175 general transcription factor II H, polypeptide 1 (62kD subunit)7052 0.40227 1.42 up Mm.27062 3110031O14Rik 100357_g_at AW121051 RIKEN cDNA 3110031O14 gene7053 0.40229 1.79 up Mm.4656 Sox6 92726_at AJ010605 SRY-box containing gene 67054 0.40233 1.18 up Mm.3439 Arhgef7 98434_at U96634 Rho guanine nucleotide exchange factor (GEF7)7055 0.40235 1.30 up Mm.3282 Diap1 104681_at U96963 diaphanous homolog 1 (Drosophila)7056 0.40248 1.67 up Mm.3539 Masp2 98481_at AB009459 mannan-binding lectin serine protease 27057 0.40259 1.35 down Mm.196502 1700025B18Rik 160124_r_at U13839 RIKEN cDNA 1700025B18 gene7058 0.40259 1.92 up Mm.21017 Pfkfb1 103297_at X98848 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 17059 0.40274 1.91 up Mm.202142 Defcr 101794_f_at U12562 defensin related cryptdin peptide7060 0.40276 1.27 down Mm.196592 2310075M17Rik 94870_f_at AW124226 RIKEN cDNA 2310075M17 gene7061 0.40281 1.44 down Mm.205266 D9Ertd25e 102004_at AI530403 DNA segment, Chr 9, ERATO Doi 25, expressed7062 0.40296 1.60 up Mm.102 Rfx2 102219_at X76089 regulatory factor (trans-acting) 27063 0.40297 1.30 down Mm.28312 0610039A15Rik 97862_s_at AI835477 RIKEN cDNA 0610039A15 gene7064 0.40297 1.20 down Mm.24584 4930579A11Rik 95444_at AW122274 RIKEN cDNA 4930579A11 gene7065 0.40323 1.15 down Mm.29430 AA408210 95136_at AW049185 expressed sequence AA4082107066 0.40345 1.52 up Mm.23695 Dhfr 104547_at J00388 dihydrofolate reductase7067 0.40346 1.38 up Mm.42083 Plcb1 92465_at U85713 phospholipase C, beta 17068 0.40352 1.31 up Mm.3470 Rxra 92235_g_at X66223 retinoid X receptor alpha7069 0.40354 1.57 up Mm.57051 Cmkbr1 99413_at U29678 chemokine (C-C) receptor 17070 0.40375 1.17 down Mm.25548 Kpna3 96010_at AW047023 karyopherin (importin) alpha 37071 0.40389 1.17 down Mm.29572 AA408242 95666_at AW123404 expressed sequence AA4082427072 0.40400 1.42 up Mm.38261 Ubce8 98597_at AW048912 ubiquitin-conjugating enzyme 87073 0.40436 1.23 down Mm.1075 2010004M01Rik 102331_at AW120586 RIKEN cDNA 2010004M01 gene7074 0.40438 1.41 up Mm.2230 Dri1 103496_at U60335 dead ringer homolog 1 (Drosophila)7075 0.40450 1.29 down Mm.200500 AI414047 97226_at AW125649 expressed sequence AI4140477076 0.40461 1.11 down Mm.196149 1110008E19Rik 93269_at AI848952 RIKEN cDNA 1110008E19 gene7077 0.40475 1.32 up Mm.153911 Pls2 101327_at U82610 plastin 2, L7078 0.40488 1.21 down Mm.423 Mm.423 161272_f_at AV321418 ESTs, Weakly similar to AF171875 1 g1-related zinc finger protein [M.muscu7079 0.40490 1.17 down Mm.171708 Zfp110 160220_at AJ242914 zinc finger protein 1107080 0.40495 1.35 down Mm.5903 Gpaa1 100911_at AB002136 GPI anchor attachment protein 17081 0.40495 1.44 up Mm.5209 Mm.5209 93145_at AI840824 ESTs7082 0.40524 1.44 up Mm.4154 Il10rb 99491_at U53696 interleukin 10 receptor, beta7083 0.40538 1.38 up Mm.648 Prnp 100606_at M18070 prion protein7084 0.40544 1.49 down Mm.204126 AA517650 101119_at AA517650 expressed sequence AA5176507085 0.40550 1.11 down Mm.22669 D11Bwg0554e 103515_at AW123409 DNA segment, Chr 11, Brigham & Women's Genetics 0554 expressed7086 0.40559 1.50 up Mm.19353 LOC56304 96973_f_at X02468 recombinant antineuraminidase single chain Ig VH and VL domains7087 0.40563 1.31 up Mm.3059 Nsmaf 160826_at AF013632 neutral sphingomyelinase (N-SMase) activation associated factor7088 0.40575 1.26 up Mm.31979 Nudel-pending 98884_r_at AI837311 nuclear distribution gene E-like7089 0.40578 1.17 down Mm.40 Cops3 99113_at AF071313 COP9 (constitutive photomorphogenic) homolog, subunit 3 (Arabidopsis thal7090 0.40578 1.56 down Mm.87837 Zfa 95800_s_at X53250 zinc finger protein, autosomal7091 0.40580 1.50 up Mm.24909 D12Ertd19e 95855_at C76460 DNA segment, Chr 12, ERATO Doi 19, expressed7092 0.40580 1.31 up Mm.56895 D17H6S56E-3 101277_at AF109905 DNA segment, Chr 17, human D6S56E 37093 0.40592 1.33 down Mm.2180 Hsp84-1 95359_at M18186 heat shock protein, 84 kDa 17094 0.40595 1.41 down Mm.201008 C77450 99362_at C77098 expressed sequence C774507095 0.40598 1.80 up Mm.7060 Naalad2 161079_at AW122909 N-acetylated alpha-linked acidic dipeptidase 27096 0.40601 1.37 up Mm.200381 Capn3 103272_at AF091998 calpain 37097 0.40603 1.54 up Mm.197701 Mup5 101635_f_at M16360 major urinary protein 57098 0.40611 1.33 up Mm.3251 Pcsk4 104674_s_at L21221 proprotein convertase subtilisin/kexin type 47099 0.40620 1.34 down Mm.1232 Mm.1232 92780_f_at M90535 Mus musculus, clone MGC:8060 IMAGE:3587523, mRNA, complete cds7100 0.40623 1.71 up Mm.22314 Abca3 160155_at AA681747 ATP-binding cassette, sub-family A (ABC1), member 37101 0.40624 1.18 down Mm.200776 AA409223 97458_at AI845935 expressed sequence AA4092237102 0.40641 1.30 up Mm.4929 Nfya 100469_at D78642 nuclear transcription factor-Y alpha7103 0.40647 2.23 up Mm.88822 Or28 96981_at AB030892 gene for odorant receptor MOR287104 0.40653 1.50 up Mm.42193 Spin 160843_at AA796214 spindlin7105 0.40663 1.16 down Mm.19101 Ddx5 93493_at X65627 DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 57106 0.40664 1.40 up Mm.4744 Gdf5 98793_at U08337 growth differentiation factor 57107 0.40667 1.34 down Mm.27979 Mela 93861_f_at M17327 melanoma antigen, 80 kDa7108 0.40684 1.20 down Mm.28115 2310001H13Rik 96124_at AI835632 RIKEN cDNA 2310001H13 gene7109 0.40695 1.22 up Mm.104491 Hsp30-pending 162420_r_at AV290470 heat shock protein, 30 kDa7110 0.40702 1.62 up Mm.27453 D5Wsu31e 161191_i_at AV250852 DNA segment, Chr 5, Wayne State University 31, expressedPage 79 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description7111 0.40705 1.23 down Mm.24365 0610042A05Rik 95420_at AW120625 RIKEN cDNA 0610042A05 gene7112 0.40709 1.27 up Mm.24676 Mm.24676 104741_at AI843023 ESTs, Highly similar to AF151847 1 CGI-89 protein [H.sapiens]7113 0.40714 1.55 up Mm.24124 Zfp96 104604_at U62908 zinc finger protein 967114 0.40719 1.21 up Mm.8068 Erf 93670_at AW048233 Est2 repressor factor7115 0.40737 1.15 down Mm.24777 Mm.24777 103771_at AI837993 ESTs7116 0.40745 1.31 down Mm.29627 AA407588 95685_at AI849678 expressed sequence AA4075887117 0.40749 1.44 up Mm.57240 Hrh1 102576_at D50095 histamine receptor H 17118 0.40762 2.58 down Mm.3787 Svs6 97698_at U19486 seminal vesicle secretion 67119 0.40785 1.56 up Mm.29758 Tcp11 97382_at X52129 t-complex protein 117120 0.40799 1.30 down Mm.42130 Insm1 102085_at AF044669 insulinoma-associated 17121 0.40814 1.64 up Mm.5101 Syt1 93005_at D37792 synaptotagmin 17122 0.40814 1.26 up Mm.29896 Rpl21 96290_f_at U93863 ribosomal protein L217123 0.40815 1.53 down Mm.2131 Ela1 93783_at M27347 elastase 1, pancreatic7124 0.40820 1.76 up Mm.5822 Mm.5822 99821_at C79629 ESTs7125 0.40836 1.17 down Mm.8552 Birc5 98458_at AI155192 baculoviral IAP repeat-containing 57126 0.40838 1.37 up Mm.196621 Rpl22 92856_at D17653 ribosomal protein L227127 0.40845 1.18 down Mm.34641 Amfr 98094_f_at AI843627 autocrine motility factor receptor7128 0.40875 1.46 down Mm.6374 Mm.6374 93409_at AA139057 ESTs7129 0.40876 1.36 down Mm.34869 Ndufa1 98117_at AW046724 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 17130 0.40884 1.44 up Mm.28035 Mm.28035 93478_at AA612483 ESTs, Weakly similar to TRHY_HUMAN TRICHOHYALI [H.sapiens]7131 0.40899 1.15 up Mm.21158 Frap1 103309_at AI853977 FK506 binding protein 12-rapamycin associated protein 17132 0.40903 1.65 up Mm.26993 Cyp3a25 104024_at Y11995 cytochrome P450, 3a257133 0.40910 1.41 up Mm.2319 Sclip 161934_f_at AV160353 Scgn10 like-protein7134 0.40932 1.47 up Mm.8007 Cmkbr6 99899_at AJ222714 chemokine (C-C) receptor 67135 0.40961 1.73 up Mm.3845 D6Ertd109e 161344_r_at AV138114 DNA segment, Chr 6, ERATO Doi 109, expressed7136 0.40970 1.36 down Mm.30412 5430400P17Rik 93700_at AI838022 RIKEN cDNA 5430400P17 gene7137 0.40992 1.18 up Mm.29867 Ndufa2 96280_at AI851603 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 27138 0.41003 1.32 up Mm.89928 Ghrhr 97652_at L07379 growth hormone releasing hormone receptor7139 0.41025 1.70 up Mm.608 2700089E24Rik 100926_at AI837334 RIKEN cDNA 2700089E24 gene7140 0.41026 1.67 down Mm.184351 Aqp4 102704_at U88623 aquaporin 47141 0.41027 1.27 up Mm.28362 AI326478 100377_f_at L33952 expressed sequence AI3264787142 0.41046 1.30 down Mm.22409 Clic4 94255_g_at AI845237 chloride intracellular channel 4 (mitochondrial)7143 0.41048 1.63 up Mm.29286 Ybx2 104440_at AF073954 Y box protein 27144 0.41048 1.68 up Mm.183095 Krt1-4 160274_at AA755053 keratin complex 1, acidic, gene 47145 0.41056 1.78 up Mm.219664 Tgfa 92369_at M92420 transforming growth factor alpha7146 0.41089 1.29 down Mm.157125 Mm.157125 102207_at AW123249 Mus musculus, clone MGC:12117 IMAGE:3710089, mRNA, complete cds7147 0.41095 1.72 up Mm.8585 Cbl 100291_at X57111 Casitas B-lineage lymphoma7148 0.41106 1.51 down Mm.42054 Zfp146 98285_at AJ224763 zinc finger protein 1467149 0.41112 1.65 up Mm.10106 Tspy-ps 94103_at AJ001379 <strong>test</strong>is specific protein-Y encoded, pseudogene7150 0.41113 1.38 up Mm.61526 Pbx1 94803_at AF020197 pre B-cell leukemia transcription factor 17151 0.41136 1.52 up Mm.17946 Gt(ROSA)26Sor 160620_at U83174 gene trap ROSA 26, Philippe Soriano7152 0.41137 1.28 down Mm.28858 2810051A14Rik 160312_at AW125031 RIKEN cDNA 2810051A14 gene7153 0.41145 1.23 up Mm.1251 Mag 161846_r_at AV331957 myelin-associated glycoprotein7154 0.41154 1.58 up Mm.1999 Attp-pending 95304_at U97571 signaling molecule ATTP7155 0.41157 1.74 down Mm.3739 D10Wsu159e 100748_at AA409010 DNA segment, Chr 10, Wayne State University 159, expressed7156 0.41159 1.50 down Mm.219659 Hist2 102557_at U62673 histone gene complex 27157 0.41169 1.42 up Mm.3368 Spi6 98405_at U96700 serine protease inhibitor 67158 0.41187 1.14 up Mm.21606 Rtn3 102137_f_at AI845856 reticulon 37159 0.41197 1.43 up Mm.3110 Ktn1 161985_f_at AV380640 kinectin 17160 0.41201 1.55 up Mm.23122 Fancg 103530_at AW049598 Fanconi anemia, complementation group G7161 0.41211 1.17 down Mm.28356 Vps29 97876_at AI842008 vacuolar protein sorting 29 (S. pombe)7162 0.41217 1.35 up Mm.97 Semcap2-pending 101950_at AF061262 semaF cytoplasmic domain associated protein 27163 0.41259 1.18 up Mm.31387 Nr5a1 101665_at C85959 nuclear receptor subfamily 5, group A, member 17164 0.41266 1.30 down Mm.20521 Hdac3 103655_at AF074882 histone deacetylase 37165 0.41273 1.58 up Mm.27768 6330403K07Rik 95559_at AI838836 RIKEN cDNA 6330403K07 gene7166 0.41280 1.39 up Mm.41787 Nme4 160473_at AI836205 expressed in non-metastatic cells 4, protein (NM23-M4)(nucleoside diphosph7167 0.41295 2.02 up Mm.7444 Viaat 101420_at AJ001598 vesicular inhibitory amino acid transporter7168 0.41324 1.83 up Mm.27881 Usmg4 161728_f_at AV268004 upregulated during skeletal muscle growth 47169 0.41335 1.34 down Mm.6973 Krtap6-1 101374_at D86420 keratin associated protein 6-17170 0.41336 1.35 up Mm.200674 C86129 95540_r_at AI574242 expressed sequence C861297171 0.41339 1.14 down Mm.38802 D11Moh35 98635_at AI854629 DNA segment, Chr 11, KL Mohlke 357172 0.41356 1.39 up Mm.42123 2310008H09Rik 160872_f_at AF034580 RIKEN cDNA 2310008H09 gene7173 0.41374 1.28 down Mm.39082 Taf1b 99041_at Y09973 TATA box binding protein (Tbp)-associated factor, RNA polymerase I, B7174 0.41383 1.21 up Mm.1641 Car4 161818_f_at AV376445 carbonic anhydrase 47175 0.41389 1.56 up Mm.5540 1810054D07Rik 101222_f_at C76819 RIKEN cDNA 1810054D07 gene7176 0.41406 1.23 down Mm.20354 Klc1 97984_i_at AA709672 kinesin light chain 17177 0.41407 1.43 down Mm.4923 Mm.4923 100465_i_at AA655823 ESTs7178 0.41411 1.36 up Mm.5457 C76132 99351_at C76132 expressed sequence C761327179 0.41421 1.36 up Mm.23692 Csnk2a1-rs4 104546_g_at U51866 casein kinase II, alpha 1 related sequence 47180 0.41426 1.20 down Mm.4793 Gaa 160516_at U49351 glucosidase, alpha, acid7181 0.41441 1.24 up Mm.35605 Cdh1 98140_at X60961 cadherin 17182 0.41442 1.48 up Mm.4094 Cyp3a13 99463_at X63023 cytochrome P450, steroid inducible 3a137183 0.41454 1.46 up Mm.21160 2200003J09Rik 160132_at AA710635 RIKEN cDNA 2200003J09 gene7184 0.41464 1.36 down Mm.31129 C79952 161112_at AV251443 expressed sequence C799527185 0.41470 1.29 down Mm.30052 D4Wsu125e 96861_at AI852376 DNA segment, Chr 4, Wayne State University 125, expressed7186 0.41471 1.42 down Mm.78093 AV308913 161206_at AV243849 expressed sequence AV3089137187 0.41483 1.50 up Mm.57229 Atoh1 102569_at D43694 atonal homolog 1 (Drosophila)7188 0.41490 1.47 up Mm.27227 5730469M10Rik 96634_at AI850090 RIKEN cDNA 5730469M10 gene7189 0.41501 1.61 up Mm.10707 Ppargc1 102240_at AF049330 peroxisome proliferative activated receptor, gamma, coactivator 17190 0.41505 1.27 down Mm.219641 Mm.219641 102686_at AI605493 Mus musculus, Similar to hypothetical protein MGC2705, clone MGC:364717191 0.41508 1.13 down Mm.196846 Rad23b 96103_f_at X92411 RAD23b homolog (S. cerevisiae)7192 0.41512 1.45 up Mm.39721 AI649392 160855_at AI035236 expressed sequence AI6493927193 0.41520 1.11 down Mm.116858 Ap4s1 104565_at AI847561 adaptor-related protein complex AP-4, sigma 17194 0.41526 1.53 up Mm.3057 Reln 161231_r_at AV263736 reelin7195 0.41528 1.38 down Mm.57038 Hes2 101724_at AB009967 hairy and enhancer of split 2 (Drosophila)7196 0.41533 1.16 up Mm.29604 D5Wsu46e 97343_at AI852735 DNA segment, Chr 5, Wayne State University 46, expressed7197 0.41533 1.36 down Mm.175032 1500001K17Rik 102018_at AI854879 RIKEN cDNA 1500001K17 gene7198 0.41535 1.23 down Mm.37562 2410142G14Rik 103428_at AW049684 RIKEN cDNA 2410142G14 gene7199 0.41555 1.18 down Mm.7335 Cnbp 101086_f_at X63866 cellular nucleic acid binding protein7200 0.41558 1.21 down Mm.29553 0610025L15Rik 95660_at AI851815 RIKEN cDNA 0610025L15 genePage 80 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description7201 0.41559 1.35 up Mm.285 Kdr 104265_at X70842 kinase insert domain protein receptor7202 0.41565 1.78 up Mm.1682 Ptpns1 103070_at AB018194 protein tyrosine phosphatase, non-receptor type substrate 17203 0.41577 1.41 down Mm.26214 5730502D15Rik 93244_at AI158563 RIKEN cDNA 5730502D15 gene7204 0.41577 1.44 down Mm.37819 6330416M07Rik 161062_r_at AW049573 RIKEN cDNA 6330416M07 gene7205 0.41579 1.50 up Mm.4974 Ncam1 100153_at X15052 neural cell adhesion molecule 17206 0.41579 1.15 down Mm.21118 AU044614 93752_at AI848393 expressed sequence AU0446147207 0.41582 1.66 up Mm.42258 Cmkbr10 98323_at AJ132336 chemokine (C-C) receptor 107208 0.41601 1.46 down Mm.10105 Psx1 102212_at AF017453 placenta specific homeobox 17209 0.41603 1.12 up Mm.22602 Atp6k 94301_at AI843269 ATPase, H+ transporting lysosomal (vacuolar proton pump), 9.2 kDa7210 0.41611 1.95 up Mm.1560 AI851258 161178_at AV232981 expressed sequence AI8512587211 0.41622 1.38 down Mm.3512 Onecut1 100737_at U95945 one cut domain, family member 17212 0.41627 1.54 up Mm.23995 Hamp 104588_at AI255961 hepcidin antimicrobial peptide7213 0.41629 1.54 down Mm.897 Pou2af1 93915_at Z54283 POU domain, class 2, associating factor 17214 0.41631 1.15 up Mm.23678 Mm.23678 103545_at AA240695 ESTs7215 0.41638 1.18 down Mm.23739 0610041O14Rik 160174_at AI851650 RIKEN cDNA 0610041O14 gene7216 0.41640 1.22 down Mm.21071 Arl2 103854_at AW049387 ADP-ribosylation-like 27217 0.41645 1.72 down Mm.39861 Gng4 99898_at U37527 guanine nucleotide binding protein (G protein), gamma 4 subunit7218 0.41649 1.35 up Mm.26587 Thra 99077_at X07750 thyroid hormone receptor alpha7219 0.41651 1.28 down Mm.26898 D9Bwg1371e 160730_at AI503987 DNA segment, Chr 9, Brigham & Women's Genetics 1371 expressed7220 0.41656 1.61 up Mm.24951 Mm.24951 95962_at AV375731 ESTs7221 0.41661 1.47 up Mm.990 Prkcm 94087_at Z34524 protein kinase C, mu7222 0.41667 1.19 up Mm.205538 AL022757 104574_at AW210607 expressed sequence AL0227577223 0.41669 1.56 up Mm.3141 Ccnd2 97504_at M83749 cyclin D27224 0.41676 1.21 down Mm.17523 0610038F07Rik 103097_at AI844487 RIKEN cDNA 0610038F07 gene7225 0.41682 1.50 up Mm.18607 Prlpa 103378_at AF011383 prolactin-like protein A7226 0.41688 1.58 up Mm.22477 Aqp9 104328_at AA967194 aquaporin 97227 0.41696 1.25 down Mm.28262 Rgs2 97844_at U67187 regulator of G-protein signaling 27228 0.41706 1.21 down Mm.21749 5430437P03Rik 93992_at AW123342 RIKEN cDNA 5430437P03 gene7229 0.41711 1.27 down Mm.12568 AW541137 102412_at AI226158 expressed sequence AW5411377230 0.41711 1.15 down Mm.29348 AI596259 95103_at AI839824 expressed sequence AI5962597231 0.41713 1.33 up Mm.19669 Pfkfb3 160641_at AI021573 inducible 6-phosphofructo-2-kinase7232 0.41720 1.28 down Mm.29541 1110004G16Rik 95657_f_at AW125164 RIKEN cDNA 1110004G16 gene7233 0.41741 1.31 up Mm.22627 Eps15 104006_at L21768 epidermal growth factor receptor pathway substrate 157234 0.41751 1.34 up Mm.15295 Ephx2 93051_at Z37107 epoxide hydrolase 2, cytoplasmic7235 0.41770 1.19 down Mm.10528 Hars 92580_at U39473 histidyl tRNA synthetase7236 0.41781 1.39 up Mm.3451 Fmr1 98441_at L23971 fragile X mental retardation syndrome 1 homolog7237 0.41786 1.54 down Mm.5116 Cutl2 93129_at U45665 cut-like 2 (Drosophila)7238 0.41789 1.37 down Mm.23845 1600017K21Rik 162487_f_at AV122373 RIKEN cDNA 1600017K21 gene7239 0.41789 1.65 up Mm.6126 Mm.6126 101614_at AA672648 ESTs7240 0.41790 1.27 down Mm.28103 1810009A15Rik 96121_at AW047866 RIKEN cDNA 1810009A15 gene7241 0.41800 1.72 up Mm.7244 Agr2 162200_r_at AV062476 anterior gradient 2 (Xenopus laevis)7242 0.41825 1.87 up Mm.371 Il4 92283_s_at X03532 interleukin 47243 0.41831 1.70 up Mm.63514 Abcc6 93407_at AB028737 ATP-binding cassette, sub-family C (CFTR/MRP), member 67244 0.41844 1.56 up Mm.5740 C78704 101234_at C78704 expressed sequence C787047245 0.41853 1.58 up Mm.10287 Dnase1l3 94107_at AF047355 deoxyribonuclease 1-like 37246 0.41868 1.20 up Mm.29323 Mm.29323 95098_at AI844756 Mus musculus, clone MGC:7865 IMAGE:3501511, mRNA, complete cds7247 0.41870 1.35 down Mm.2493 Kcna1 103787_at Y00305 potassium voltage-gated channel, shaker-related subfamily, member 17248 0.41883 2.01 down Mm.44170 Vdr 99965_at D31969 vitamin D receptor7249 0.41887 1.33 down Mm.1120 Ebaf 102345_at D83921 endometrial bleeding associated factor7250 0.41895 1.35 down Mm.42053 H2-T18 98284_f_at X03052 histocompatibility 2, T region locus 187251 0.41926 1.52 up Mm.148315 Nthl1 93385_at Y09688 nth (endonuclease III)-like 1 (E.coli)7252 0.41926 1.65 down Mm.29544 Capn10 161307_f_at AV350809 calpain 107253 0.41929 1.49 up Mm.33671 Ctse 104696_at AJ009840 cathepsin E7254 0.41932 1.19 down Mm.213114 AI788588 102863_at AI550530 expressed sequence AI7885887255 0.41945 1.15 up Mm.195503 Mrps24 101085_at AI854257 mitochondrial ribosomal protein S247256 0.41957 1.66 up Mm.212538 H2-Q8 97173_f_at M27134 histocompatibility 2, Q region locus 87257 0.41960 1.71 up 102916_s_at AB0102667258 0.41967 1.62 up Mm.189913 Mm.189913 161460_r_at AV344027 EST7259 0.41977 1.55 up Mm.24760 4921528E07Rik 160935_at AI036466 RIKEN cDNA 4921528E07 gene7260 0.41994 1.42 up Mm.20236 Daf1 103617_at D63679 decay accelerating factor 17261 0.41996 1.65 down Mm.1312 Tcrb-V8.2 94202_at L37871 T-cell receptor beta, variable 8.27262 0.41999 1.18 down Mm.29803 Aldh9a1 96243_f_at AW120804 aldehyde dehydrogenase 9, subfamily A17263 0.42006 1.26 up Mm.24851 Mm.24851 95939_i_at AW047237 ESTs7264 0.42015 1.19 down Mm.886 2210419D22Rik 93877_at AI834777 RIKEN cDNA 2210419D22 gene7265 0.42017 1.50 up Mm.57239 Orm3 102575_at S38219 orosomucoid 37266 0.42017 1.31 up Mm.4945 Notch3 92956_at X74760 Notch gene homolog 3, (Drosophila)7267 0.42030 1.16 down Mm.24403 Mm.24403 103738_at AW122812 ESTs, Weakly similar to B24264 proline-rich protein MP3 - mouse [M.muscu7268 0.42032 1.48 up Mm.7515 Calu 101107_at U81829 calumenin7269 0.42033 1.61 up Mm.22777 Plf 94838_r_at K02245 proliferin7270 0.42044 1.29 up 100567_at M204977271 0.42048 1.10 down Mm.30068 D10Ertd190e 96872_at AI835846 DNA segment, Chr 10, ERATO Doi 190, expressed7272 0.42072 1.20 down Mm.117547 AA407358 103720_at AI449034 expressed sequence AA4073587273 0.42081 1.21 down Mm.9440 Ptdss1 161864_f_at AV068306 phosphatidylserine synthase 17274 0.42089 1.46 down Mm.7601 Sla 99876_at U29056 src-like adaptor protein7275 0.42094 1.43 up Mm.56955 Tal2 101310_at M81077 T-cell acute lymphocytic leukemia 27276 0.42099 1.52 up Mm.9537 Lcn2 161684_r_at AV210775 lipocalin 27277 0.42106 1.77 up Mm.12837 Nos3 94167_at U53142 nitric oxide synthase 3, endothelial cell7278 0.42107 1.13 down Mm.444 Idb1 100050_at M31885 inhibitor of DNA binding 17279 0.42112 1.17 down Mm.28806 Ubce7ip3-pending 94457_at AW049735 ubiquitin conjugating enzyme 7 interacting protein 37280 0.42132 1.41 up Mm.4678 Stk3 98775_at U28726 serine/threonine kinase 3 (Ste20, yeast homolog)7281 0.42133 1.66 up Mm.2682 Mep1b 94936_at L15193 meprin 1 beta7282 0.42142 1.71 up Mm.26147 Mm.26147 94415_at AA710439 ESTs7283 0.42149 1.27 up Mm.85892 1110020A23Rik 95635_g_at AI848107 RIKEN cDNA 1110020A23 gene7284 0.42156 1.21 up Mm.153486 Afg3l1 103625_at AA797556 AFG3(ATPase family gene 3)-like 1 (yeast)7285 0.42158 1.56 up Mm.66913 Zfp60 93446_at U48721 zinc finger protein 607286 0.42162 1.21 up Mm.39001 1110018N15Rik 92336_at AI834936 RIKEN cDNA 1110018N15 gene7287 0.42169 1.51 down Mm.22370 Mm.22370 103503_at AI842940 Mus musculus, Similar to phospholipase C, gamma 2 (phosphatidylinositol-s7288 0.42184 1.39 up Mm.28905 AW050213 104414_at AW050194 expressed sequence AW0502137289 0.42186 1.31 up Mm.5879 Tyms 93236_s_at M13352 thymidylate synthase7290 0.42240 1.84 up Mm.37682 Ercc4 92704_at AC004155 excision repair cross-complementing rodent repair deficiency, complementatPage 81 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description7291 0.42241 1.26 up Mm.3140 Mpdz 100728_at AJ131869 multiple PDZ domain protein7292 0.42245 1.55 up Mm.1379 Matn1 102785_at U35035 matrilin 1, cartilage matrix protein 17293 0.42264 1.55 up Mm.3174 Lifr 97006_s_at X99778 leukemia inhibitory factor receptor7294 0.42297 1.29 down Mm.218790 Tcf7l2 102241_f_at AF107298 transcription factor 7-like 2, T-cell specific, HMG-box7295 0.42301 1.61 up Mm.87835 V2r12 95798_f_at AF011422 vomeronasal 2, receptor, 127296 0.42301 1.53 up Mm.24640 Grb10 93691_s_at U18996 growth factor receptor bound protein 107297 0.42302 1.40 up Mm.197816 Mm.197816 162360_f_at AV223598 Mus musculus, Similar to hypothetical protein FLJ22405, clone MGC:192907298 0.42305 1.39 down Mm.190436 2010012F05Rik 99472_at AI845515 RIKEN cDNA 2010012F05 gene7299 0.42311 1.26 down Mm.3395 1110003B01Rik 162326_at AV084635 RIKEN cDNA 1110003B01 gene7300 0.42317 1.47 up Mm.5043 Fos 160901_at V00727 FBJ osteosarcoma oncogene7301 0.42328 1.68 up Mm.144218 1500026A19Rik 161066_at AA111463 RIKEN cDNA 1500026A19 gene7302 0.42361 1.20 up Mm.27123 4921525H23Rik 96616_at AI891629 RIKEN cDNA 4921525H23 gene7303 0.42375 1.61 down Mm.2831 Nap1l4 161505_i_at AV130885 nucleosome assembly protein 1-like 47304 0.42383 1.43 up Mm.5133 Mtnr1a 101190_at U52222 melatonin receptor 1A7305 0.42397 1.49 up Mm.7331 Pbx3 96580_at AF020199 pre B-cell leukemia transcription factor 37306 0.42397 1.22 up Mm.16084 Tpst1 103032_at AF038008 protein-tyrosine sulfotransferase 17307 0.42402 1.27 up Mm.45752 1300007F04Rik 101432_at AI504100 RIKEN cDNA 1300007F04 gene7308 0.42402 1.21 down Mm.88777 Fts 101894_s_at X71978 fused toes7309 0.42404 1.78 up Mm.30049 C1qbp 96857_at W41861 complement component 1, q subcomponent binding protein7310 0.42412 1.70 up Mm.29487 1810027D10Rik 97322_at AI835093 RIKEN cDNA 1810027D10 gene7311 0.42421 1.30 up Mm.38445 Tmod3 99013_f_at AI846797 tropomodulin 37312 0.42426 1.22 up Mm.2186 Rpo2-3 160146_r_at D83999 RNA polymerase II 37313 0.42436 1.44 up Mm.16831 Ckb 162257_i_at AV339532 creatine kinase, brain7314 0.42438 1.20 down Mm.3294 Ppp5c 97532_at AF018262 protein phosphatase 5, catalytic subunit7315 0.42441 1.41 down Mm.199172 AV206827 162402_r_at AV279579 expressed sequence AV2068277316 0.42463 1.19 down Mm.28638 Sh3bgr 96205_at AW048272 SH3-binding domain glutamic acid-rich protein7317 0.42470 1.58 up Mm.1438 Kcnab1 162087_f_at AV335854 potassium voltage-gated channel, shaker-related subfamily, beta member 17318 0.42479 1.22 down Mm.3506 Arg2 98473_at AF032466 arginase type II7319 0.42494 1.54 up Mm.12949 Foxc1 160604_at AF045017 forkhead box C17320 0.42496 1.19 up Mm.196043 Idh3a 94534_at AI835446 isocitrate dehydrogenase 3 (NAD+) alpha7321 0.42506 1.26 up Mm.25065 D9Ertd306e 96375_at C80249 DNA segment, Chr 9, ERATO Doi 306, expressed7322 0.42523 1.41 up Mm.3441 Ryr3 97126_at D38218 ryanodine receptor 37323 0.42534 1.57 up Mm.24796 D7Ertd187e 95934_at AA575399 DNA segment, Chr 7, ERATO Doi 187, expressed7324 0.42538 1.23 down Mm.23467 D5Ertd189e 103538_at AW121328 DNA segment, Chr 5, ERATO Doi 189, expressed7325 0.42542 1.43 up Mm.214500 1810027O01Rik 93639_r_at M94349 RIKEN cDNA 1810027O01 gene7326 0.42590 1.41 up Mm.44063 C79576 92653_at AI482432 expressed sequence C795767327 0.42595 1.81 up Mm.252 Nqo1 100725_at M36660 NAD(P)H dehydrogenase, quinone 17328 0.42595 1.76 up Mm.14302 Cmkbr5 102719_f_at X94151 chemokine (C-C) receptor 57329 0.42595 1.53 down Mm.28787 Klf3 100010_at U36340 Kruppel-like factor 3 (basic)7330 0.42596 1.35 up Mm.5047 Zic2 98844_at AW049464 zinc finger protein of the cerebellum 27331 0.42601 1.55 up Mm.4925 Lyl1 100467_at X57687 lymphoblastomic leukemia7332 0.42609 1.24 down Mm.143817 Nek7 102827_at AW124633 NIMA (never in mitosis gene a)-related expressed kinase 77333 0.42631 1.10 down Mm.27951 1810015M01Rik 97277_at AI844179 RIKEN cDNA 1810015M01 gene7334 0.42650 1.67 up Mm.1408 Adm 102798_at U77630 adrenomedullin7335 0.42667 1.34 down Mm.25319 4930507D05Rik 94368_at AW049139 RIKEN cDNA 4930507D05 gene7336 0.42675 1.20 down Mm.197515 Tuba2 98759_f_at M28727 tubulin alpha 27337 0.42678 1.66 up Mm.25789 Csna 96030_at M36780 casein alpha7338 0.42713 1.22 down Mm.2820 Glk 97820_at AB027012 galactokinase7339 0.42763 1.28 up Mm.1411 Lig3 102803_at U66058 ligase III, DNA, ATP-dependent7340 0.42781 1.50 up Mm.89202 Ccxcr1 97053_at AB028459 chemokine (C motif) XC receptor 17341 0.42787 1.55 up Mm.10805 Col13a1 102262_r_at U30292 procollagen, type XIII, alpha 17342 0.42796 1.34 up Mm.23959 Trim13 103691_at AI592541 tripartite motif protein 137343 0.42796 1.46 up Mm.57227 Hoxd13 102567_at X99291 homeo box D137344 0.42803 1.26 up Mm.25185 AI035632 96491_at AI035632 expressed sequence AI0356327345 0.42807 1.59 up Mm.22513 Kifc3 104335_at AW124084 kinesin family member C37346 0.42811 1.14 down Mm.24277 2700018N07Rik 104626_at AI787137 RIKEN cDNA 2700018N07 gene7347 0.42813 1.50 down Mm.140330 2300002L21Rik 95747_at AI841112 RIKEN cDNA 2300002L21 gene7348 0.42825 1.27 down Mm.1483 Tnk2 102850_at AF037260 tyrosine kinase, non-receptor, 27349 0.42827 1.45 up Mm.56915 Csf3r 93198_at M58288 colony stimulating factor 3 receptor (granulocyte)7350 0.42839 1.67 up 101201_r_at T256057351 0.42847 1.30 down Mm.22521 1190004M21Rik 104339_at AW060236 RIKEN cDNA 1190004M21 gene7352 0.42858 1.59 up Mm.195461 Rhced 103340_at AF057524 Rhesus blood group CE and D7353 0.42888 1.10 up Mm.181968 1700060B08Rik 94374_at AI850378 RIKEN cDNA 1700060B08 gene7354 0.42891 1.40 up Mm.23801 Vax1 95391_at AB020495 ventral anterior homeobox containing gene 17355 0.42893 1.56 up Mm.142722 Ngfg 161840_f_at AV043739 nerve growth factor, gamma7356 0.42893 1.30 down Mm.19015 Srr 93488_at AI840579 serine racemase7357 0.42894 1.34 down Mm.20472 Veli2-pending 103253_at AF087694 vertebrate homolog of C. elegans Lin-7 type 27358 0.42898 1.70 up Mm.15802 Epb4.2 102908_at U04055 erythrocyte protein band 4.27359 0.42901 1.24 up Mm.21048 1110025F07Rik 103848_at AW121188 RIKEN cDNA 1110025F07 gene7360 0.42913 1.13 down Mm.129578 Mm.129578 160962_at W71352 Mus musculus, Similar to BCL2-associated athanogene 2, clone MGC:287867361 0.42918 1.22 down Mm.43397 Mrpl54 99630_at AW060257 mitochondrial ribosomal protein L547362 0.42919 1.35 up Mm.156583 Cals1 102773_at X61397 carbonic anhydrase-like sequence 17363 0.42922 1.69 up Mm.19170 Metap2 93505_at AB003144 methionine aminopeptidase 27364 0.42928 1.50 up Mm.27711 1700037H04Rik 161519_f_at AV210958 RIKEN cDNA 1700037H04 gene7365 0.42939 1.31 down Mm.27001 AI425994 160995_at AI425994 EST AI4259947366 0.42946 1.23 up Mm.29585 Cacna1g 104460_at AJ012569 calcium channel, voltage-dependent, T type, alpha 1G subunit7367 0.42947 1.21 up Mm.1978 Cte1 103581_at Y14004 cytosolic acyl-CoA thioesterase 17368 0.42955 2.35 down Mm.25014 C79179 96365_at C79179 expressed sequence C791797369 0.42955 1.72 down Mm.3392 Pak3 161021_at U39738 p21 (CDKN1A)-activated kinase 37370 0.42958 1.43 up Mm.263 Reg3g 162187_f_at AV049722 regenerating islet-derived 3 gamma7371 0.42960 1.44 up 102723_at V015267372 0.42965 1.53 up Mm.218551 Mm.218551 101687_r_at C79518 ESTs7373 0.42967 1.50 up Mm.4095 Xist 99126_at L04961 inactive X specific transcripts7374 0.42976 1.20 up Mm.29072 R75565 96781_at AI838293 expressed sequence R755657375 0.42983 1.12 up Mm.9703 Atox1 101984_at AF004591 ATX1 (antioxidant protein 1) homolog 1 (yeast)7376 0.42995 1.35 up Mm.117581 Ncl 160521_at U01139 nucleolin7377 0.43012 1.53 down Mm.6156 AA673486 93376_at AA673486 expressed sequence AA6734867378 0.43012 1.22 down Mm.85763 D4Ertd27e 100290_f_at AI197337 DNA segment, Chr 4, ERATO Doi 27, expressed7379 0.43014 1.47 up Mm.56915 Csf3r 95808_g_at U05894 colony stimulating factor 3 receptor (granulocyte)7380 0.43024 1.49 down Mm.12842 Vcl 94963_at AI462105 vinculinPage 82 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description7381 0.43028 1.60 up Mm.4511 AI504145 162378_r_at AV245223 expressed sequence AI5041457382 0.43037 1.25 down Mm.1104 Ube1x 162497_r_at AV154427 ubiquitin-activating enzyme E1, Chr X7383 0.43039 1.53 up Mm.26693 B4galt2 104005_at AB019541 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 27384 0.43048 1.35 down Mm.12479 1700128E15Rik 102297_at AW046082 RIKEN cDNA 1700128E15 gene7385 0.43061 1.78 up Mm.23895 Tekt2 103684_at AB027138 tektin 27386 0.43065 1.37 up Mm.20449 Mpp3 103247_at AF079366 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)7387 0.43072 1.16 down Mm.157711 Elac2 97167_g_at W49316 elaC homolog 2 (E. coli)7388 0.43080 1.43 up Mm.218360 Mm.218360 96214_at AA672784 Mus musculus, clone IMAGE:3983821, mRNA, partial cds7389 0.43082 1.33 up Mm.4512 1110001J05Rik 161042_at AI324801 RIKEN cDNA 1110001J05 gene7390 0.43097 1.79 up Mm.4461 Il5 98374_at X06271 interleukin 57391 0.43099 1.27 down Mm.20920 Lrf 103826_at AF086830 leukemia/lymphoma related factor7392 0.43131 1.10 down Mm.382 Dlgh1 160849_at U93309 discs, large homolog 1 (Drosophila)7393 0.43141 1.60 up Mm.740 Mm.740 99868_at AA145988 EST7394 0.43153 1.13 up Mm.297 Actb 95705_s_at J04181 actin, beta, cytoplasmic7395 0.43155 1.29 down Mm.20430 Zfp105 95318_at AF045565 zinc finger protein 1057396 0.43157 1.50 up Mm.89918 Podxl 100394_at AB028048 podocalyxin-like7397 0.43160 1.23 up Mm.16973 Lect2 102938_at AB009687 leukocyte cell-derived chemotaxin 27398 0.43161 1.19 down Mm.202662 AV021402 96130_at AA822531 expressed sequence AV0214027399 0.43168 1.64 up Mm.80 Afp 161629_i_at AV037200 alpha fetoprotein7400 0.43184 1.72 up Mm.161070 Mm.161070 101670_at AA589511 ESTs7401 0.43184 1.77 up Mm.153202 3300001M08Rik 103928_at AI788018 RIKEN cDNA 3300001M08 gene7402 0.43189 1.10 down Mm.17537 Cgbp-pending 103099_f_at AI663971 CpG binding protein7403 0.43190 1.24 up Mm.258 Atp5g1 161324_r_at AV100202 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subuni7404 0.43190 1.62 down Mm.214491 Pld1 101627_at U87868 phospholipase D17405 0.43191 1.45 up Mm.24963 C77681 95967_at C77695 expressed sequence C776817406 0.43195 1.66 up Mm.25292 Krt2-16 96503_at X65505 keratin complex 2, basic, gene 167407 0.43198 1.30 up Mm.197519 5031415C07Rik 93778_at AA717815 RIKEN cDNA 5031415C07 gene7408 0.43202 1.31 down Mm.140246 Zfp91 94064_at U05343 zinc finger protein 917409 0.43204 1.48 up 99805_at X984567410 0.43206 1.17 up Mm.34298 1300018I05Rik 98049_at AI853458 RIKEN cDNA 1300018I05 gene7411 0.43214 1.15 down Mm.200417 ORF60 94386_at AI850140 open reading frame 607412 0.43222 1.24 up Mm.3182 Icsbp 98002_at M32489 interferon concensus sequence binding protein7413 0.43232 1.21 up Mm.21297 Sb1 103894_at AW060871 SETA binding protein 17414 0.43239 1.33 up Mm.35784 Sox3 103302_r_at AA866668 SRY-box containing gene 37415 0.43241 1.34 down Mm.28188 Gcs1 96139_at AF001797 glucosidase 17416 0.43241 1.19 down Mm.4383 Bin1 92220_s_at U60884 myc box dependent interacting protein 17417 0.43251 1.27 up Mm.2133 AV028425 103900_at AW124150 expressed sequence AV0284257418 0.43260 1.47 up Mm.89956 Abcc1a 99329_at AF022908 ATP-binding cassette, sub-family C (CFTR/MRP), member 1a7419 0.43273 1.66 up Mm.24611 Pros1 104728_at L27439 protein S (alpha)7420 0.43276 1.36 up Mm.4594 Mybl2 161160_f_at AV214934 myeloblastosis oncogene-like 27421 0.43278 1.41 up Mm.20396 Crat 161989_f_at AV238359 carnitine acetyltransferase7422 0.43280 1.26 down Mm.143977 Hrsp12 96048_at U50631 heat-responsive protein 127423 0.43304 1.65 down Mm.195898 Pbp 93124_at U43206 phosphatidylethanolamine binding protein7424 0.43315 1.65 up Mm.4932 Hoxd1 98820_g_at M87802 homeo box D17425 0.43322 1.41 up Mm.157012 Tcrb-V13 99389_at M21673 T-cell receptor beta, variable 137426 0.43326 1.36 down Mm.27041 Map3k3 94946_at U43187 mitogen activated protein kinase kinase kinase 37427 0.43338 1.21 down Mm.24765 C79397 102131_f_at AU014874 expressed sequence C793977428 0.43342 1.68 up Mm.203896 Lman1 161288_r_at AV027479 lectin, mannose-binding, 17429 0.43347 1.61 up Mm.1248 Cdc45l 102403_at AF098068 cell division cycle 45 homolog (S. cerevisiae)-like7430 0.43367 1.28 up 92395_r_at AB0102667431 0.43376 1.63 up Mm.196407 Igk-V21 97566_f_at AF045024 immunoglobulin kappa chain variable 21 (V21)7432 0.43394 1.30 down Mm.31395 Cpe 99642_i_at X61232 carboxypeptidase E7433 0.43406 1.38 up Mm.10154 Tesk1 102033_at AB003494 <strong>test</strong>is specific protein kinase 17434 0.43407 1.47 up Mm.16373 H2-DMa 162346_f_at AV153894 histocompatibility 2, class II, locus DMa7435 0.43407 1.58 up Mm.7507 Nkx2-6 99873_at AF045150 NK2 transcription factor related, locus 6 (Drosophila)7436 0.43411 1.13 down Mm.101274 2010008E23Rik 94417_at AI852949 RIKEN cDNA 2010008E23 gene7437 0.43411 1.32 down Mm.24002 1700023O11Rik 104593_at AI849396 RIKEN cDNA 1700023O11 gene7438 0.43417 1.37 up Mm.199549 AW146114 102015_at AI840678 expressed sequence AW1461147439 0.43422 1.34 up Mm.3283 G0s2 97531_at X95280 G0/G1 switch gene 27440 0.43423 1.39 down Mm.28397 C76649 97888_at AI849676 expressed sequence C766497441 0.43423 1.64 up Mm.3746 Naca 98570_at AI956211 nascent polypeptide-associated complex alpha polypeptide7442 0.43426 1.46 up Mm.140568 1100001I22Rik 96308_r_at AW121947 RIKEN cDNA 1100001I22 gene7443 0.43426 1.67 up Mm.7486 Bmp2 161901_r_at AV374010 bone morphogenetic protein 27444 0.43436 1.54 up Mm.215173 Ptcra 98354_at U16958 pre T-cell antigen receptor alpha7445 0.43436 1.24 down Mm.6670 Prkag1 100632_at AF036535 protein kinase, AMP-activated, gamma 1 non-catalytic subunit7446 0.43455 1.69 up Mm.3177 Ly64 98000_at J04634 lymphocyte antigen 647447 0.43469 1.39 down Mm.44497 AI851387 102922_at AI851387 expressed sequence AI8513877448 0.43470 1.29 up Mm.18590 Tm4sf2 93326_at D26483 transmembrane 4 superfamily member 27449 0.43478 1.32 up Mm.22628 AI790651 104368_at U51204 expressed sequence AI7906517450 0.43507 1.13 down Mm.4437 Mapk14 99978_s_at D83073 mitogen activated protein kinase 147451 0.43514 2.18 up Mm.944 Img 101970_at D78572 integral membrane glycoprotein7452 0.43518 1.20 down Mm.4891 Dgsc 100142_at X95480 DiGeorge syndrome gene c7453 0.43520 1.35 up Mm.14410 Try2 92873_f_at X04574 trypsin 27454 0.43528 1.64 up Mm.1421 Adamts1 160606_r_at D67076 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin7455 0.43535 1.17 up Mm.203 Apex 93559_at D90374 apurinic/apyrimidinic endonuclease7456 0.43540 1.73 up Mm.69185 Mm.69185 161624_r_at AV027707 EST7457 0.43571 1.21 down Mm.38460 1500012D08Rik 98610_at AW047926 RIKEN cDNA 1500012D08 gene7458 0.43590 1.34 down Mm.18974 Gabpa 103440_at AW226540 GA repeat binding protein, alpha7459 0.43605 1.24 up Mm.20964 Gnao 103844_at M36778 guanine nucleotide binding protein, alpha o7460 0.43634 1.56 up Mm.193462 Pira1 95784_at U96682 paired-Ig-like receptor A17461 0.43644 1.12 down Mm.21728 Psma7 93988_at AI836676 proteasome (prosome, macropain) subunit, alpha type 77462 0.43663 1.20 up Mm.21199 Obph1-pending 103311_at AW121299 oxysterol binding protein homolog 17463 0.43673 1.23 down Mm.60219 C79328 96921_at AW060765 expressed sequence C793287464 0.43690 1.22 up Mm.9821 Sah 102193_at AA791891 SA rat hypertension-associated homolog7465 0.43707 1.24 up Mm.1231 Cyr61 92777_at M32490 cysteine rich protein 617466 0.43708 1.14 down Mm.22717 W91701 104390_at AI836916 expressed sequence W917017467 0.43716 1.26 down Mm.2538 Pld2 94371_at U87557 phospholipase D27468 0.43718 1.43 up Mm.4316 Arnt 97185_at AI451564 aryl hydrocarbon receptor nuclear translocator7469 0.43722 1.37 up Mm.2265 Snrp1c 101292_f_at X79214 U1 small nuclear ribonucleoprotein 1C7470 0.43723 1.17 down Mm.24046 AI854770 95889_at AI854770 expressed sequence AI854770Page 83 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description7471 0.43756 1.56 down Mm.26852 Mm.26852 161334_r_at AV115721 ESTs, Moderately similar to zinc finger protein 277 [Homo sapiens] [H.sapie7472 0.43759 1.34 up Mm.4211 Slc8a1 99524_at AF004666 solute carrier family 8 (sodium/calcium exchanger), member 17473 0.43764 1.34 up Mm.28297 BC002318 162005_at AV243190 hypothetical protein, MGC:83037474 0.43770 1.44 up Mm.3170 Papola 160681_at AI131735 poly (A) polymerase alpha7475 0.43775 1.59 up Mm.27553 9530019H02Rik 103792_at AA041969 RIKEN cDNA 9530019H02 gene7476 0.43780 1.22 down Mm.140785 Scd1 94056_at M21285 stearoyl-Coenzyme A desaturase 17477 0.43783 1.29 up Mm.18939 Pmm1 93360_at AF007267 phosphomannomutase 17478 0.43791 1.31 up Mm.52067 Uchl5 100512_at AI838853 ubiquitin carboxyl-terminal esterase L57479 0.43792 1.46 up Mm.320 Pola2 161739_r_at AV314625 DNA polymerase alpha 2, 68 kDa7480 0.43793 2.26 up Mm.757 Arha2 101768_at AF014374 ras homolog A27481 0.43803 1.36 down Mm.19310 Cors-pending 103570_at AI315647 collagenous repeat-containing sequence7482 0.43804 1.40 down Mm.424 Atp1b3 99579_at U59761 ATPase, Na+/K+ transporting, beta 3 polypeptide7483 0.43804 1.46 down Mm.29708 D4Wsu114e 162028_f_at AV366396 DNA segment, Chr 4, Wayne State University 114, expressed7484 0.43813 1.37 up Mm.2821 6530401N04Rik 161437_f_at AV349142 RIKEN cDNA 6530401N04 gene7485 0.43814 1.58 up Mm.42222 Utrn 92507_at Y12229 utrophin7486 0.43827 1.48 up Mm.29429 3110038L01Rik 95134_at AW124483 RIKEN cDNA 3110038L01 gene7487 0.43833 1.71 up Mm.14438 AU044919 92740_at J00475 expressed sequence AU0449197488 0.43842 1.36 up Mm.24870 AA409944 95481_at AI844374 expressed sequence AA4099447489 0.43849 1.40 down Mm.37199 Gstm3 97681_f_at J03953 glutathione S-transferase, mu 37490 0.43863 1.64 down Mm.38931 Mme 92331_at M81591 membrane metallo endopeptidase7491 0.43899 1.24 up Mm.27692 1110003P16Rik 97204_s_at AI850983 RIKEN cDNA 1110003P16 gene7492 0.43917 1.61 down Mm.6891 Calb3 161835_at AV037012 calbindin-D9K7493 0.43935 1.56 up Mm.6856 Pttg1 101026_at AF071209 pituitary tumor-transforming 17494 0.43938 1.25 up Mm.18210 Msh6 93299_at AF031087 mutS homolog 6 (E. coli)7495 0.43939 1.26 down Mm.14064 Mat1a 92864_at L13622 methionine adenosyltransferase I, alpha7496 0.43946 1.18 down Mm.20188 1190006C12Rik 93548_at AW122942 RIKEN cDNA 1190006C12 gene7497 0.43954 1.31 up Mm.28848 AI182287 94468_at AI842102 expressed sequence AI1822877498 0.43959 1.25 up Mm.4450 Esp 92662_g_at U36488 embryonic stem cell phosphatase7499 0.43981 2.08 up Mm.3126 Fhl1 97499_at AI839950 four and a half LIM domains 17500 0.43999 1.39 up Mm.24873 Nola1 160720_at AI845303 nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs)7501 0.44001 1.12 up Mm.16716 Lamp1 160089_at M32015 lysosomal membrane glycoprotein 17502 0.44002 1.66 up Mm.29017 4733401H14Rik 96770_at AA607761 RIKEN cDNA 4733401H14 gene7503 0.44003 1.31 up Mm.33896 Hhex 98408_at AB017132 hematopoietically expressed homeobox7504 0.44007 1.23 up Mm.12508 Kpna2 92790_at D55720 karyopherin (importin) alpha 27505 0.44027 1.81 down Mm.12948 F2rl3 94191_at AF080215 coagulation factor II (thrombin) receptor-like 37506 0.44027 1.66 up Mm.36225 Prlpi 92274_at AB019118 prolactin-like protein I7507 0.44032 1.36 up Mm.39103 Mcam 160458_at AI853261 melanoma cell adhesion molecule7508 0.44033 1.30 up Mm.20440 Htr4 95323_at Y09585 5 hydroxytryptamine (serotonin) receptor 47509 0.44041 1.24 down Mm.9925 Idh1 160571_at AF020039 isocitrate dehydrogenase 1 (NADP+), soluble7510 0.44044 1.71 up Mm.154915 Rps29 162335_at AV097886 ribosomal protein S297511 0.44053 1.38 up Mm.137885 Plod3 161253_i_at AV319503 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 37512 0.44057 1.27 down Mm.182913 Csnk1d 97263_s_at AI846289 casein kinase 1, delta7513 0.44061 1.42 up Mm.4654 Ptpn5 162053_i_at AV381397 protein tyrosine phosphatase, non-receptor type 57514 0.44075 1.26 up Mm.29901 1500034J01Rik 161719_f_at AV261613 RIKEN cDNA 1500034J01 gene7515 0.44077 1.27 down Mm.154662 Col9a1 104483_at L12215 procollagen, type IX, alpha 17516 0.44080 1.21 up Mm.44513 Cckbr 101344_at AF019371 cholecystokinin B receptor7517 0.44089 1.29 up Mm.1122 Alox12-ps2 161947_f_at AV359829 arachidonate 12-lipoxygenase, pseudogene 27518 0.44093 1.61 up Mm.23868 Mm.23868 161794_i_at AV348607 Mus musculus brain cDNA, clone MNCb-41377519 0.44115 1.79 up Mm.324 Amy2 97524_f_at X02578 amylase 2, pancreatic7520 0.44126 1.54 up Mm.4139 Rtkn 162243_f_at AV170878 rhotekin7521 0.44139 1.14 down Mm.391 9130413I22Rik 160457_at AW125397 RIKEN cDNA 9130413I22 gene7522 0.44156 1.31 down Mm.636 Selenbp1 100596_at M32032 selenium binding protein 17523 0.44190 1.30 up Mm.24078 C79732 160967_at AA189555 expressed sequence C797327524 0.44204 1.26 down Mm.22347 Pnn 94239_at Y08701 pinin7525 0.44216 1.22 up Mm.12625 Mtap4 92795_at M72414 microtubule-associated protein 47526 0.44224 1.53 up Mm.8817 Mm.8817 101541_at AA824072 ESTs, Weakly similar to S50828 hypothetical protein - Escherichia coli [E.co7527 0.44229 1.73 up Mm.89935 Dsc3 97655_at Y11169 desmocollin 37528 0.44232 1.50 up Mm.34064 Stat5b 92199_at U21110 signal transducer and activator of transcription 5B7529 0.44235 1.24 up Mm.24765 C79397 104749_at AW123623 expressed sequence C793977530 0.44241 1.72 down Mm.29786 Mm.29786 161172_f_at AV228594 Mus musculus, clone MGC:36705 IMAGE:3673890, mRNA, complete cds7531 0.44244 1.17 down Mm.3330 Polm 104690_at AI462166 polymerase (DNA directed), mu7532 0.44248 1.13 down Mm.3464 Flt1 98453_at D88690 FMS-like tyrosine kinase 17533 0.44288 1.30 up Mm.2620 Slc19a1 162123_f_at AV375147 solute carrier family 19 (sodium/hydrogen exchanger), member 17534 0.44289 1.82 up Mm.1252 Mcpt5 102407_at M68898 mast cell protease 57535 0.44297 1.33 up Mm.195090 Vpreb2 100295_at M34597 pre-B lymphocyte gene 27536 0.44310 1.50 up Mm.14455 Tgfbi 161157_r_at AV231282 transforming growth factor, beta induced, 68 kDa7537 0.44312 1.24 down Mm.30009 Arl6ip5 97424_at AW049647 ADP-ribosylation-like factor 6 interacting protein 57538 0.44318 1.31 down Mm.71015 2700053F16Rik 96831_at AA755004 RIKEN cDNA 2700053F16 gene7539 0.44326 1.20 up Mm.42195 Ruvbl1 99537_at AF100694 RuvB-like protein 17540 0.44340 1.18 down Mm.141197 Wbp11 98617_at AF071186 WW domain binding protein 117541 0.44359 1.58 up Mm.9213 Esr1 161113_at AA023625 estrogen receptor 1 (alpha)7542 0.44361 1.36 up Mm.29878 1300006C06Rik 161729_f_at AV268039 RIKEN cDNA 1300006C06 gene7543 0.44373 1.32 down Mm.24216 Rbbp9 93222_at AF039563 retinoblastoma binding protein 97544 0.44374 1.17 down Mm.200788 C77286 103981_at AI842281 expressed sequence C772867545 0.44396 1.26 down Mm.61526 Pbx1 94325_at AW124932 pre B-cell leukemia transcription factor 17546 0.44396 1.33 up Mm.17519 Zfp259 103096_at U41287 zinc finger protein 2597547 0.44401 1.40 down Mm.57093 Cacng1 100896_at AJ006306 calcium channel, voltage-dependent, gamma subunit 17548 0.44410 1.60 down Mm.4543 Dlx1 98394_at U51000 distal-less homeobox 17549 0.44413 1.25 up Mm.200220 A230106A15Rik 104030_at AI848841 RIKEN cDNA A230106A15 gene7550 0.44441 1.22 down Mm.35837 2510006D16Rik 98528_at AI854901 RIKEN cDNA 2510006D16 gene7551 0.44450 1.25 up Mm.22383 Mm.22383 160156_at AA981015 Mus musculus, Similar to hypothetical protein DKFZp566A1524, clone MGC7552 0.44454 1.16 down Mm.6565 Fkbp8 100613_at AF030635 FK506 binding protein 8 (38 kDa)7553 0.44456 1.30 down Mm.45048 Stam2 103286_at AB012611 signal transducing adaptor molecule (SH3 domain and ITAM motif) 27554 0.44474 1.38 down Mm.28521 2310066K23Rik 160786_f_at AI843424 RIKEN cDNA 2310066K23 gene7555 0.44484 1.25 down Mm.29163 Cast 95062_at AB026997 calpastatin7556 0.44485 1.18 down Mm.30652 Mm.30652 96594_at AA615831 ESTs7557 0.44505 1.72 up Mm.4817 Abcd2 92913_at Z48670 ATP-binding cassette, sub-family D (ALD), member 27558 0.44506 1.40 up Mm.20181 Pde4b 103610_at AI180687 phosphodiesterase 4B, cAMP specific7559 0.44509 1.39 up Mm.3990 Skd3 162000_r_at AV332176 suppressor of K+ transport defect 37560 0.44512 1.18 up Mm.27622 Dbnl 95529_at U58884 drebrin-likePage 84 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description7561 0.44515 1.33 up Mm.6180 Klrb1c 93380_at M77678 killer cell lectin-like receptor subfamily A member 1C7562 0.44530 1.21 up Mm.141993 Mbnl 96354_at AI854802 muscleblind-like (Drosophila)7563 0.44531 1.13 up Mm.44123 AI449518 160490_at AI847127 expressed sequence AI4495187564 0.44540 1.18 up Mm.29098 AU015645 162031_f_at AV367320 expressed sequence AU0156457565 0.44542 1.43 up Mm.29088 0610013D04Rik 162403_at AV282092 RIKEN cDNA 0610013D04 gene7566 0.44551 1.16 up Mm.26116 Smarcb1 96050_at AJ011740 SWI/SNF related, matrix associated, actin dependent regulator of chromatin,7567 0.44577 1.18 down Mm.25042 1110004L07Rik 94340_at AW124224 RIKEN cDNA 1110004L07 gene7568 0.44579 1.15 up Mm.55982 4930522D07Rik 103218_at J04761 RIKEN cDNA 4930522D07 gene7569 0.44581 1.48 down Mm.5034 Pde7a 100489_at U68171 phosphodiesterase 7A7570 0.44598 1.24 down Mm.56895 D17H6S56E-3 95654_at AF109905 DNA segment, Chr 17, human D6S56E 37571 0.44600 1.32 up Mm.5130 Wnt10a 98862_at U61969 wingless related MMTV integration site 10a7572 0.44601 1.57 up Mm.12625 Mtap4 161781_at AV361479 microtubule-associated protein 47573 0.44618 1.27 down Mm.200980 4933429H19Rik 99501_at AA882416 RIKEN cDNA 4933429H19 gene7574 0.44625 1.43 down Mm.56918 G6pd2 101294_g_at Z84471 glucose-6-phosphate dehydrogenase 27575 0.44627 1.43 up Mm.57198 Hpvc2 101827_at X52164 human papillomavirus 18 E5 central sequence motif gene 27576 0.44636 1.25 up Mm.5140 Slc7a3 93133_at U70859 solute carrier family 7 (cationic amino acid transporter, y+ system), member7577 0.44644 1.42 up Mm.28047 2310022K15Rik 161646_r_at AV087256 RIKEN cDNA 2310022K15 gene7578 0.44653 1.26 down Mm.6157 2510042P03Rik 160908_r_at AI839518 RIKEN cDNA 2510042P03 gene7579 0.44688 1.15 down Mm.2344 Gnb1 94853_at U29055 guanine nucleotide binding protein, beta 17580 0.44694 1.63 up Mm.14301 Oas1a 102717_at X58077 2'-5' oligoadenylate synthetase 1A7581 0.44702 1.75 up Mm.1023 Mm.1023 161204_r_at AV260414 ESTs7582 0.44727 1.63 up Mm.39093 Shox2 99042_s_at U66918 short stature homeobox 27583 0.44731 1.41 up Mm.394 Icam2 99053_at X65493 intercellular adhesion molecule 27584 0.44740 1.29 up Mm.36248 Vrl1 98963_at AB021665 vanilloid receptor-like protein 17585 0.44751 1.17 down Mm.24538 Cop1-pending 95437_at AI836139 constitutive photomorphogenic protein 1 (Arabidopsis)7586 0.44756 1.19 up Mm.6424 Itgb5 162218_f_at AV106844 integrin beta 57587 0.44760 1.36 up Mm.181290 Mrpl49 94283_at AI854652 mitochondrial ribosomal protein L497588 0.44762 1.33 down Mm.19804 Spg4 98428_at AJ246002 spastic paraplegia 4 homolog (human)7589 0.44769 1.46 down Mm.25031 Mm.25031 95982_at AI415393 ESTs7590 0.44778 1.55 up Mm.27538 Tcl1b1 96694_at AA675004 T-cell leukemia/lymphoma 1B, 17591 0.44780 1.50 up Mm.3960 Irf3 162425_f_at AV292430 interferon regulatory factor 37592 0.44783 1.33 up Mm.504 Bmx 98840_at AF012104 BMX non-receptor tyrosine kinase7593 0.44786 1.29 up Mm.89930 Mem1 97653_at X95349 maternal embryonic message 17594 0.44787 1.73 up Mm.206792 Mageb2 95781_at U19032 melanoma antigen, family B, 27595 0.44807 1.22 up Mm.46535 Mm.46535 161487_f_at AV080542 ESTs, Moderately similar to AT93 MOUSE ATP SYNTHASE LIPID-BINDING7596 0.44824 1.20 down Mm.29153 2610205H19Rik 95058_f_at AW121984 RIKEN cDNA 2610205H19 gene7597 0.44827 1.25 up Mm.22587 G4-1-pending 160691_at AI850270 phosphatase subunit gene g4-17598 0.44858 1.40 up Mm.3292 Grin1 104686_at D10028 glutamate receptor, ionotropic, NMDA1 (zeta 1)7599 0.44880 1.25 up Mm.20615 Pex11a 103660_at AF093669 peroxisomal biogenesis factor 11a7600 0.44894 1.76 up Mm.24899 Mm.24899 95853_at C76257 ESTs7601 0.44900 1.71 up Mm.196286 4833408P15Rik 94479_at AW124464 RIKEN cDNA 4833408P15 gene7602 0.44908 1.10 up Mm.103427 Mm.103427 96546_r_at AI447510 ESTs, Highly similar to unnamed protein product [H.sapiens]7603 0.44909 1.26 up Mm.37756 Eppb9-pending 98992_at AB030483 endothelial precursor protein B97604 0.44914 1.28 up Mm.2902 Ptprn 104422_at U11812 protein tyrosine phosphatase, receptor-type, N7605 0.44924 1.16 down Mm.27112 Mm.27112 96614_at AA763368 ESTs, Moderately similar to Y247_HUMAN HYPOTHETICAL PROTEIN KIAA7606 0.44937 1.42 up Mm.34637 Catna2 92228_at D25282 catenin alpha 27607 0.44953 1.21 down Mm.8021 Cntnap1 94626_at AF039833 contactin associated protein 17608 0.44953 1.20 down Mm.204682 Mm.204682 102670_at AI848706 Mus musculus Hcc8 mRNA, complete cds7609 0.44961 1.70 down Mm.86922 Ror2 93723_at AB010384 receptor tyrosine kinase-like orphan receptor 27610 0.44962 1.28 up Mm.1741 Relb 103091_at M83380 avian reticuloendotheliosis viral (v-rel) oncogene related B7611 0.44965 1.24 up Mm.8137 Chd1 101459_at L10410 chromodomain helicase DNA binding protein 17612 0.44992 1.27 up Mm.29859 Eif2s2 160365_at AW125491 eukaryotic translation initiation factor 2, subunit 2 (beta, 38kDa)7613 0.44993 1.48 up Mm.28161 Zfp36l2 160273_at AA960603 zinc finger protein 36, C3H type-like 27614 0.45009 1.13 down Mm.20946 Psmc3 93735_f_at D49686 proteasome (prosome, macropain) 26S subunit, ATPase 37615 0.45010 1.54 up Mm.43213 9030402K04Rik 99620_at AW060546 RIKEN cDNA 9030402K04 gene7616 0.45015 1.64 up Mm.24486 AA408304 94664_at AA408304 expressed sequence AA4083047617 0.45025 1.21 up Mm.7233 Mm.7233 161081_at AA733664 ESTs, Weakly similar to S24577 ovarian protein - fruit fly [D.melanogaster]7618 0.45028 1.25 down Mm.29674 Ptk2 97363_at M95408 PTK2 protein tyrosine kinase 27619 0.45029 1.28 down Mm.5021 Ddr1 100155_at L57509 discoidin domain receptor family, member 17620 0.45034 1.21 up Mm.29638 2900070I05Rik 97358_at AI851356 RIKEN cDNA 2900070I05 gene7621 0.45052 1.42 up Mm.27254 Enpp1 104174_at J02700 ectonucleotide pyrophosphatase/phosphodiesterase 17622 0.45062 1.40 down Mm.22842 Cd2 95373_at X06143 CD2 antigen7623 0.45083 1.47 up Mm.22242 AW112037 104260_at AW123061 expressed sequence AW1120377624 0.45123 1.24 up Mm.2770 Igf1 95545_at X04480 insulin-like growth factor 17625 0.45131 1.43 up Mm.1404 Mesp1 102795_at D83674 mesoderm posterior 17626 0.45148 1.44 up Mm.16958 Nipsnap1 93251_at AJ001260 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein ho7627 0.45172 1.79 up Mm.23757 Mm.23757 99681_at T25554 EST7628 0.45193 1.21 down Mm.56 Dscr1 100555_at AI846152 Down syndrome critical region homolog 1 (human)7629 0.45194 1.65 up Mm.89926 Polk 162307_at AV007877 polymerase (DNA directed) kappa7630 0.45205 1.52 up Mm.1193 Enpep 102373_at M29961 glutamyl aminopeptidase7631 0.45220 1.17 up Mm.7500 Ftl1 162479_f_at AV097950 ferritin light chain 17632 0.45231 1.13 down Mm.26783 Mm.26783 94933_at AI853739 Mus musculus, clone MGC:6974 IMAGE:3154632, mRNA, complete cds7633 0.45232 1.26 down Mm.549 Ifngr 100552_at M28233 interferon gamma receptor7634 0.45234 1.23 down Mm.29101 2410004M09Rik 94556_at AI746846 RIKEN cDNA 2410004M09 gene7635 0.45234 1.55 up Mm.26609 D8Ertd69e 94922_i_at AA543502 DNA segment, Chr 8, ERATO Doi 69, expressed7636 0.45253 1.35 up Mm.2289 1500015A01Rik 103524_at AA691078 RIKEN cDNA 1500015A01 gene7637 0.45259 1.13 up Mm.5980 Mm.5980 97163_g_at AI563699 ESTs, Weakly similar to NFM MOUSE NEUROFILAMENT TRIPLET M PRO7638 0.45261 1.62 down Mm.21919 C80248 161854_f_at AV336853 expressed sequence C802487639 0.45264 1.15 up Mm.195498 Slc25a17 97472_at AJ006341 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein7640 0.45287 1.35 up Mm.20439 Cdon 102621_at AF090866 cell adhesion molecule-related/down-regulated by oncogenes7641 0.45292 1.14 down Mm.3261 Cnih 97528_at AF022811 cornichon homolog (Drosophila)7642 0.45315 1.28 down Mm.1158 Atp6n2 102273_at M31226 ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic ac7643 0.45318 1.90 up Mm.15621 Cftr 94758_s_at X72694 cystic fibrosis transmembrane conductance regulator homolog7644 0.45321 1.42 up Mm.12932 Blm 102631_at AB008674 Bloom syndrome homolog (human)7645 0.45341 1.85 up Mm.390 Cd152 97718_at X05719 CD152 antigen7646 0.45344 1.53 up Mm.47384 Clecsf6 92762_at AJ133533 C-type (calcium dependent, carbohydrate recognition domain) lectin, superfa7647 0.45355 1.33 down Mm.199019 AW047776 100058_at AW047776 expressed sequence AW0477767648 0.45359 2.00 up Mm.22763 Fstl 94833_at M91380 follistatin-like7649 0.45362 1.17 up Mm.200168 AA672638 99503_at AW045204 expressed sequence AA6726387650 0.45394 1.34 up Mm.88820 Syt10 96979_at AB026807 synaptotagmin 10Page 85 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description7651 0.45424 1.30 up Mm.1853 Galgt1 103367_at U18975 UDP-N-acetyl-alpha-D-galactosamine:(N-acetylneuraminyl)-galactosylglucos7652 0.45445 1.51 up Mm.41268 Zac1 92502_at X95504 zinc finger protein regulator of apoptosis and cell cycle arrest7653 0.45448 1.32 down Mm.31979 Nudel-pending 98883_r_at AW047320 nuclear distribution gene E-like7654 0.45466 1.46 up Mm.4509 Runx2 92676_at D14636 runt related transcription factor 27655 0.45468 1.21 up Mm.56905 Tbc1d1 96637_at U33005 tre-2/USP6, BUB2, cdc16) domain family, member 17656 0.45473 1.34 down Mm.4635 Kif3a 100398_at D12645 kinesin family member 3a7657 0.45489 2.37 up Mm.157783 AI893585 101746_i_at X94419 expressed sequence AI8935857658 0.45492 1.25 down Mm.1444 Cops7a 92875_s_at AI852725 COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis tha7659 0.45500 1.26 up Mm.20343 Ring1 103236_at Y12881 ring finger protein 17660 0.45504 1.22 down Mm.20901 Pex11b 103814_at AF093671 peroxisomal biogenesis factor 11b7661 0.45511 1.25 up Mm.4312 Slc9a1 161201_r_at AV242253 solute carrier family 9 (sodium/hydrogen exchanger), member 17662 0.45527 1.41 up Mm.17336 Hemt1 102950_at AJ011023 hematopoietic cell transcript 17663 0.45551 1.23 down Mm.27330 Smarce1 96651_at AF035263 SWI/SNF related, matrix associated, actin dependent regulator of chromatin,7664 0.45556 1.37 up Mm.10651 Gch 102313_at L09737 GTP cyclohydrolase 17665 0.45559 1.58 up Mm.5516 C76614 99357_at C76640 expressed sequence C766147666 0.45567 1.42 down Mm.34942 DXErtd242e 97142_at C80153 DNA segment, Chr X, ERATO Doi 242, expressed7667 0.45571 1.15 up Mm.597 Pafah1b3 100576_at U57746 platelet-activating factor acetylhydrolase, isoform 1b, alpha1 subunit7668 0.45584 1.42 down Mm.45579 Igifbp 92689_at AB019505 interferon gamma inducing factor binding protein7669 0.45586 1.31 up Mm.202383 Hnf4 92713_at D29015 hepatic nuclear factor 47670 0.45591 1.19 up Mm.100113 Rpl10 98342_at M93980 ribosomal protein 107671 0.45598 1.19 up Mm.2295 AI842396 95378_at AI842396 expressed sequence AI8423967672 0.45608 1.20 down Mm.196173 Actg 96573_at M21495 actin, gamma, cytoplasmic7673 0.45611 1.28 up Mm.17519 Zfp259 161881_f_at AV366702 zinc finger protein 2597674 0.45612 1.19 down Mm.5624 Ddx16 96212_at AI853918 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 167675 0.45627 1.45 down Mm.45108 Ddx25 92678_at AA982686 DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 257676 0.45627 1.58 down Mm.12882 Hsd17b7 94177_at Y15733 hydroxysteroid 17-beta dehydrogenase 77677 0.45627 1.18 down Mm.28994 Mm.28994 103716_at AI851218 Mus musculus, clone MGC:6302 IMAGE:2655022, mRNA, complete cds7678 0.45643 1.12 down Mm.27328 2310042M24Rik 96649_at AW046552 RIKEN cDNA 2310042M24 gene7679 0.45654 1.43 up Mm.41268 Zac1 92501_s_at X95503 zinc finger protein regulator of apoptosis and cell cycle arrest7680 0.45656 1.47 up Mm.1061 Fdx1 160062_i_at W41701 ferredoxin 17681 0.45656 1.22 up Mm.1215 Crybb2 162019_r_at AV360936 crystallin, beta B27682 0.45664 1.12 down Mm.790 Tparl 160549_at M23568 TPA regulated locus7683 0.45664 1.45 up Mm.25845 Adh4 103982_s_at AJ245750 alcohol dehydrogenase 4 (class II), pi polypeptide7684 0.45668 1.43 down Mm.38233 Ptk9 93646_at U82324 protein tyrosine kinase 97685 0.45669 1.27 down Mm.43278 Olfm1 99623_s_at D78265 olfactomedin 17686 0.45678 1.33 down Mm.27506 0610039N19Rik 95026_at AW047688 RIKEN cDNA 0610039N19 gene7687 0.45681 1.31 up Mm.20392 Dnajb8 103645_at AI326313 DnaJ (Hsp40) homolog, subfamily B, member 87688 0.45689 1.40 down Mm.4991 Tpo 98832_at X60703 thyroid peroxidase7689 0.45691 1.10 down Mm.29266 Lmo2 96810_at AI154017 LIM only 27690 0.45693 1.25 down Mm.44883 Mm.44883 161050_at AI504506 ESTs7691 0.45701 1.39 up Mm.28512 Mm.28512 162048_r_at AV378443 Mus musculus, clone IMAGE:5037434, mRNA, partial cds7692 0.45703 1.86 up Mm.202299 AA407132 95917_at AA407132 expressed sequence AA4071327693 0.45705 1.56 down Mm.180905 Dpysl3 101503_at X87817 dihydropyrimidinase-like 37694 0.45715 1.43 down Mm.5749 AI450241 97610_f_at AI450241 expressed sequence AI4502417695 0.45723 1.52 up Mm.4644 Zp3r 100402_f_at U17108 zona pellucida 3 receptor7696 0.45774 1.14 down Mm.29599 Mrps14 97342_at AW060867 mitochondrial ribosomal protein S147697 0.45778 1.30 up Mm.30255 H2afy 160399_r_at AA646966 H2A histone family, member Y7698 0.45792 1.36 up Mm.7283 Mmp15 93612_at D86332 matrix metalloproteinase 157699 0.45839 1.25 up Mm.46033 AI562151 160891_at AA980377 expressed sequence AI5621517700 0.45843 1.11 up Mm.5236 Rgds 100530_at L07924 ral guanine nucleotide dissociation stimulator7701 0.45843 1.29 down Mm.20818 2600002E23Rik 93591_at AW045323 RIKEN cDNA 2600002E23 gene7702 0.45850 1.40 up Mm.27086 2410012A13Rik 161616_f_at AV354117 RIKEN cDNA 2410012A13 gene7703 0.45917 1.31 down Mm.27139 1300019N10Rik 104164_at AI181257 RIKEN cDNA 1300019N10 gene7704 0.45947 1.41 up Mm.4546 Crhr2 98395_at U21729 corticotropin releasing hormone receptor 27705 0.45950 1.30 up Mm.5761 C78859 101596_at C78859 expressed sequence C788597706 0.45954 1.15 down Mm.20755 Supt6h 103668_at U40375 suppressor of Ty 6 homolog (S. cerevisiae)7707 0.45955 1.54 up Mm.14120 V2r10 94722_f_at AF011420 vomeronasal 2, receptor, 107708 0.45958 1.70 up Mm.24596 1700013L23Rik 161837_r_at AV040792 RIKEN cDNA 1700013L23 gene7709 0.45963 1.21 down Mm.1761 Clk 93274_at M38381 CDC-like kinase7710 0.45967 1.23 up Mm.29663 Top1 95694_at X70956 topoisomerase (DNA) I7711 0.45970 1.49 up Mm.2534 Pstpip1 103946_at U87814 proline-serine-threonine phosphatase-interacting protein 17712 0.45973 1.31 down Mm.21950 AI426782 160678_at AA871166 EST AI4267827713 0.45984 1.63 up Mm.29117 Mm.29117 94563_at AJ011080 Mus musculus mRNA for alpha-albumin protein7714 0.45993 1.28 up Mm.27230 Rbms1 94972_at AB026569 RNA binding motif, single stranded interacting protein 17715 0.46002 1.57 up Mm.203898 2810407J07Rik 93846_at AF030522 RIKEN cDNA 2810407J07 gene7716 0.46004 1.16 up Mm.29606 0610009C03Rik 95677_at AA881621 RIKEN cDNA 0610009C03 gene7717 0.46024 1.34 up Mm.214929 Mm.214929 93848_at AW124635 ESTs, Weakly similar to serine/threonine kinase 25 (yeast); Ste20-like kinas7718 0.46027 1.77 up Mm.30088 Clpx 94961_at AI851962 caseinolytic protease X (E.coli)7719 0.46053 1.44 up Mm.4952 Irs1 92205_at AF090738 insulin receptor substrate 17720 0.46066 1.83 down Mm.22970 Nxph3 102573_at U56651 neurexophilin 37721 0.46081 1.23 up Mm.1640 Cdr2 93094_at U88588 cerebellar degeneration-related 27722 0.46088 1.56 up Mm.22657 3300001P10Rik 94317_at AW214124 RIKEN cDNA 3300001P10 gene7723 0.46093 1.19 up Mm.157910 Adam28 101723_r_at U06146 a disintegrin and metalloprotease domain 287724 0.46109 1.24 up Mm.21108 1110061B18Rik 93749_at AI848045 RIKEN cDNA 1110061B18 gene7725 0.46114 1.52 up Mm.121 Tnfrsf7 102281_at L24495 tumor necrosis factor receptor superfamily, member 77726 0.46118 1.47 up Mm.1276 Sag 94150_at M24086 retinal S-antigen7727 0.46118 1.23 down Mm.218627 Ppil2 95110_at AI265655 peptidylprolyl isomerase (cyclophilin)-like 27728 0.46126 1.37 up Mm.142 Lck 161265_f_at AV314529 lymphocyte protein tyrosine kinase7729 0.46128 1.14 up Mm.196578 Mtch1-pending 95689_at AI840995 mitochondrial carrier homolog 17730 0.46145 1.45 up Mm.10810 P140-pending 94130_at AF040944 P140 gene7731 0.46148 1.34 up Mm.2726 Itpr1 93895_s_at M21530 inositol 1,4,5-triphosphate receptor 17732 0.46156 1.17 up Mm.43415 Cox6a1 99631_f_at U08440 cytochrome c oxidase, subunit VI a, polypeptide 17733 0.46160 1.38 down Mm.18889 1700008H23Rik 160634_at AI848201 RIKEN cDNA 1700008H23 gene7734 0.46165 1.43 up Mm.108076 Pfkp 97833_at AI853802 phosphofructokinase, platelet7735 0.46190 1.28 down Mm.24472 AA408038 103744_at AI852760 expressed sequence AA4080387736 0.46201 1.46 up Mm.133560 Ddx10 99878_at AW124460 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 10 (RNA helicase)7737 0.46208 1.22 up Mm.88842 Olfr37b 97000_s_at AJ133425 olfactory receptor 37b7738 0.46218 1.29 up Mm.44276 Mm.44276 102143_at AW047018 EST7739 0.46244 1.90 up Mm.29651 1110030L07Rik 162398_at AV274917 RIKEN cDNA 1110030L07 gene7740 0.46261 1.23 up Mm.16110 Ccne1 103034_at X75888 cyclin E1Page 86 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description7741 0.46274 1.47 down Mm.27086 2410012A13Rik 162258_f_at AV339602 RIKEN cDNA 2410012A13 gene7742 0.46279 1.28 up Mm.1662 Fxyd3 103060_at AW060519 FXYD domain-containing ion transport regulator 37743 0.46293 1.26 up Mm.931 Il2rb 100764_at M28052 interleukin 2 receptor, beta chain7744 0.46304 1.35 down Mm.1236 Gadd45a 102292_at U00937 growth arrest and DNA-damage-inducible 45 alpha7745 0.46314 1.89 up Mm.200671 Mdm4 93338_at AF007110 transformed mouse 3T3 cell double minute 47746 0.46320 1.15 down Mm.12926 Pparbp 160603_at AF000294 peroxisome proliferator activated receptor binding protein7747 0.46323 1.46 up Mm.3174 Lifr 104657_at D26177 leukemia inhibitory factor receptor7748 0.46326 1.42 up Mm.1227 Msr1 94140_at M59446 macrophage scavenger receptor 17749 0.46328 1.33 down Mm.86654 Mtap6 101855_at Y14754 microtubule-associated protein 67750 0.46348 1.27 up Mm.3207 Lrpb7 161392_f_at AV257486 leucine rich protein, B7 gene7751 0.46352 1.32 up Mm.27804 Ierepo4-pending 161454_r_at AV294503 immediate early response, erythropoietin 47752 0.46353 1.26 up Mm.21772 Smarcd2 161414_f_at AV317359 SWI/SNF related, matrix associated, actin dependent regulator of chromatin,7753 0.46360 1.11 up Mm.21687 0610025L06Rik 104074_at AW212109 RIKEN cDNA 0610025L06 gene7754 0.46370 1.40 up Mm.21297 Sb1 162238_r_at AV149482 SETA binding protein 17755 0.46392 1.65 up Mm.24461 Mm.24461 95912_at AA407546 ESTs7756 0.46404 1.19 down Mm.17917 2600015J22Rik 160100_at AI834847 RIKEN cDNA 2600015J22 gene7757 0.46406 1.57 up Mm.7103 Pbx2 96808_at AF030001 pre B-cell leukemia transcription factor 27758 0.46426 1.17 down Mm.29940 Mm.29940 104477_at AW047643 ESTs7759 0.46432 1.71 up Mm.157783 AI893585 101320_f_at L28059 expressed sequence AI8935857760 0.46434 1.50 up 97746_f_at X668617761 0.46434 1.12 down Mm.46401 Son 100401_at AA673981 Son cell proliferation protein7762 0.46440 1.51 up Mm.4763 Mdfi 100434_s_at U57822 MyoD family inhibitor7763 0.46445 1.49 up Mm.6840 5730507C05Rik 104586_at AI842878 RIKEN cDNA 5730507C05 gene7764 0.46467 1.40 up Mm.7097 AA675035 101673_r_at AA675035 expressed sequence AA6750357765 0.46472 1.37 up Mm.25250 AI648812 103939_at AW121399 expressed sequence AI6488127766 0.46474 1.25 down Mm.22526 2310004B05Rik 104342_i_at AI845798 RIKEN cDNA 2310004B05 gene7767 0.46480 1.39 up Mm.36571 D4Ertd58e 101688_at C77672 DNA segment, Chr 4, ERATO Doi 58, expressed7768 0.46487 1.26 down Mm.18652 Sms 98136_at AF031486 spermine synthase7769 0.46500 1.31 up Mm.21526 Tnfrsf19 160670_at AW122863 tumor necrosis factor receptor superfamily, member 197770 0.46503 1.45 up Mm.138866 Apoe 161321_i_at AV092985 apolipoprotein E7771 0.46508 1.07 down Mm.16763 Aldo1 161889_f_at AV102160 aldolase 1, A isoform7772 0.46514 1.59 down Mm.4347 Xrcc1 99938_at U02887 X-ray repair complementing defective repair in Chinese hamster cells 17773 0.46530 1.91 up Mm.32472 Fgf14 99424_at U66204 fibroblast growth factor 147774 0.46531 1.17 up Mm.22597 2310042E05Rik 94300_f_at AI839497 RIKEN cDNA 2310042E05 gene7775 0.46533 1.51 down Mm.5097 Cncg4 161210_f_at AV246992 cyclic nucleotide gated channel 47776 0.46553 1.40 up Mm.42033 Gab2 98276_at AB018414 growth factor receptor bound protein 2-associated protein 27777 0.46577 1.30 up Mm.4776 Acrv1 161403_r_at AV278150 acrosomal vesicle protein 17778 0.46613 1.47 up Mm.25 Gas2 94337_at M21828 growth arrest specific 27779 0.46623 1.27 up Mm.57044 C5r1 101728_at S46665 complement component 5, receptor 17780 0.46625 1.51 up Mm.24001 Mef2c 97357_at AI426400 myocyte enhancer factor 2C7781 0.46628 1.23 down Mm.3863 Por 161668_f_at AV140072 P450 (cytochrome) oxidoreductase7782 0.46629 1.35 up Mm.42184 Vamp5 92496_at AF035643 vesicle-associated membrane protein 57783 0.46634 1.25 up Mm.3983 Figf 92365_at X99572 c-fos induced growth factor7784 0.46648 1.23 up Mm.6856 Pttg1 101027_s_at AF069051 pituitary tumor-transforming 17785 0.46657 1.75 up Mm.25652 Gjb6 161607_r_at AV346646 gap junction membrane channel protein beta 67786 0.46713 1.61 up 101669_at AA5894927787 0.46749 1.41 up Mm.153710 B3galt3 98961_at AI841494 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 37788 0.46755 1.41 up Mm.1425 Adcy8 94737_at U85021 adenylate cyclase 87789 0.46764 1.39 up Mm.1674 Atp5j2 93114_at AI843947 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f, isoform7790 0.46785 1.74 up Mm.29699 Ap1b1 161249_at AV314679 adaptor protein complex AP-1, beta 1 subunit7791 0.46793 1.40 up Mm.2299 Nmrk 95380_at L19057 non MHC restricted killing associated7792 0.46802 1.54 up Mm.2380 Npas2 95390_at U77969 neuronal PAS domain protein 27793 0.46805 1.14 down Mm.1664 Rab33b 97058_f_at AW208630 RAB33B, member of RAS oncogene family7794 0.46810 1.39 up Mm.12802 Nppc 94156_at D28873 natriuretic peptide precursor type C7795 0.46822 1.48 up Mm.88589 D1Ertd83e 96431_at C77977 DNA segment, Chr 1, ERATO Doi 83, expressed7796 0.46848 1.35 up Mm.144308 Igh-1 102159_at M86750 immunoglobulin heavy chain 1 (serum IgG2a)7797 0.46870 1.38 down Mm.203876 AA408650 161105_at AV296012 expressed sequence AA4086507798 0.46904 1.39 up Mm.7335 Cnbp 101087_r_at X63866 cellular nucleic acid binding protein7799 0.46911 1.28 down Mm.42191 Odz3 92500_at AB025412 odd Oz/ten-m homolog 3 (Drosophila)7800 0.46926 1.68 up Mm.156759 2410018L13Rik 161886_at AV096455 RIKEN cDNA 2410018L13 gene7801 0.46939 1.31 up Mm.44784 Adam22 161039_at AB009674 a disintegrin and metalloprotease domain 227802 0.46954 1.10 up Mm.196148 2700067I02Rik 94323_at AW048132 RIKEN cDNA 2700067I02 gene7803 0.46973 1.63 up Mm.24999 C78878 95973_at C78878 expressed sequence C788787804 0.46985 1.47 up Mm.14121 V2r16 100679_at AF011426 vomeronasal 2, receptor, 167805 0.47034 1.18 down Mm.28600 D13Wsu64e 98912_at AW047811 DNA segment, Chr 13, Wayne State University 64, expressed7806 0.47035 1.28 up Mm.28362 AI326478 101743_f_at X94420 expressed sequence AI3264787807 0.47053 1.18 down Mm.52 1810033A19Rik 100527_at AW124744 RIKEN cDNA 1810033A19 gene7808 0.47056 1.61 up Mm.41973 Ddc8-pending 92455_at Y09878 <strong>test</strong>is specific protein, Ddc87809 0.47074 1.27 down Mm.9287 Mtssk 160938_at U02313 microtubule associated <strong>test</strong>is specific serine/threonine protein kinase7810 0.47084 1.20 up Mm.212 1110013G13Rik 103881_at AA691185 RIKEN cDNA 1110013G13 gene7811 0.47085 1.62 down Mm.20429 Prox1 102614_at AF061576 prospero-related homeobox 17812 0.47085 1.16 down Mm.27339 5430411C10Rik 96655_g_at AI852916 RIKEN cDNA 5430411C10 gene7813 0.47111 1.32 down Mm.29391 1110007F23Rik 96826_at AI845827 RIKEN cDNA 1110007F23 gene7814 0.47130 1.83 down Mm.33669 Cldn1 97546_at AF072127 claudin 17815 0.47139 1.24 up Mm.2950 Pms2 104454_at U28724 postmeiotic segregation increased 2 (S. cerevisiae)7816 0.47159 1.24 up Mm.24570 AA589481 103757_at AA755810 expressed sequence AA5894817817 0.47180 1.26 down Mm.876 Cyp2b9 101862_at M21855 cytochrome P450, 2b9, phenobarbitol inducible, type a7818 0.47181 1.28 up Mm.2334 Madh2 104536_at U60530 MAD homolog 2 (Drosophila)7819 0.47184 1.33 up Mm.35523 D2Ertd93e 97165_r_at C77278 DNA segment, Chr 2, ERATO Doi 93, expressed7820 0.47192 1.34 up Mm.33065 Edg6 104687_at AJ006074 endothelial differentiation, G-protein-coupled receptor 67821 0.47194 1.47 up Mm.24922 D12Ertd123e 95953_at C76770 DNA segment, Chr 12, ERATO Doi 123, expressed7822 0.47199 1.16 up Mm.20945 Rgs19ip1 93733_r_at AF104358 regulator of G-protein signaling 19 interacting protein 17823 0.47226 1.42 up Mm.1424 Ext1 102811_at X96639 exostoses (multiple) 17824 0.47238 1.24 down Mm.28768 Ptges 104406_at AI060798 prostaglandin E synthase7825 0.47248 1.15 down Mm.2080 Gtl3 93588_at Z54179 gene trap locus 37826 0.47255 1.41 up Mm.42241 Barx1 162321_f_at AV073804 BarH-like homeobox 17827 0.47263 1.37 up Mm.24973 C77874 95970_at C78196 expressed sequence C778747828 0.47289 1.35 up 94717_f_at K012387829 0.47298 1.36 up Mm.683 Oaz1 161360_at AV212241 ornithine decarboxylase antizyme7830 0.47301 1.56 down Mm.5727 2610019F03Rik 161405_r_at AV280467 RIKEN cDNA 2610019F03 genePage 87 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description7831 0.47303 1.21 down Mm.33285 1700030G05Rik 98397_at AI852694 RIKEN cDNA 1700030G05 gene7832 0.47305 1.18 down Mm.41304 Gpnat1 94369_at AW123026 glucosamine-phosphate N-acetyltransferase 17833 0.47311 1.16 up Mm.7329 Gamt 161644_f_at AV080704 guanidinoacetate methyltransferase7834 0.47338 1.17 up Mm.4454 Elk3 160373_i_at AI839175 ELK3, member of ETS oncogene family7835 0.47342 1.09 up Mm.28058 Ndufb5 97307_f_at AI842808 NADH dehydrogenase (ubiquinone) 1 beta subcomplex 57836 0.47376 1.93 down Mm.87699 Actl7b 101864_at AI173190 actin-like 7b7837 0.47378 1.36 up Mm.15409 Limk1 102889_r_at X86569 LIM-domain containing, protein kinase7838 0.47387 1.44 up Mm.2871 AU020082 96559_at AI607745 expressed sequence AU0200827839 0.47401 1.28 up 93665_at X560077840 0.47405 1.59 up Mm.200653 D18875 162010_r_at AV246802 expressed sequence D188757841 0.47410 1.26 down Mm.30165 Mm.30165 160394_at AI854302 Mus musculus, Similar to CGI-87 protein, clone IMAGE:3491602, mRNA, pa7842 0.47415 1.19 down Mm.18795 1300010O06Rik 160110_at AW124007 RIKEN cDNA 1300010O06 gene7843 0.47433 1.40 up Mm.2524 Dmc1h 96498_at D64107 disrupted meiotic cDNA 1 homolog7844 0.47436 1.33 up Mm.41801 2610511E03Rik 160474_at AW046278 RIKEN cDNA 2610511E03 gene7845 0.47444 1.55 up Mm.15630 Six3 102901_at D83144 sine oculis-related homeobox 3 homolog (Drosophila)7846 0.47457 1.24 up Mm.2998 Nedd1 160823_at D10712 neural precursor cell expressed, developmentally down-regulated gene 17847 0.47462 1.21 up Mm.8003 Mc5r 99896_at U08354 melanocortin 5 receptor7848 0.47464 1.52 up Mm.56948 Nt5 93202_at L12059 5' nucleotidase7849 0.47482 1.46 up Mm.731 Il12rb1 98240_at U23922 interleukin 12 receptor, beta 17850 0.47485 1.45 up Mm.89769 Krt2-6g 101569_at AB033744 keratin complex 2, basic, gene 6g7851 0.47492 1.54 up Mm.20857 Zfp125 103269_f_at AJ005350 zinc finger protein 1257852 0.47501 1.21 up Mm.182439 Th1l 94015_at AW060447 TH1-like homolog (Drosophila)7853 0.47502 1.47 up Mm.3542 Pthr 98482_at X78936 parathyroid hormone receptor7854 0.47513 1.34 up Mm.2982 Dnajb1 96254_at AB028272 DnaJ (Hsp40) homolog, subfamily B, member 17855 0.47527 1.49 up Mm.196581 Mapk1 161583_at AV317327 mitogen activated protein kinase 17856 0.47527 1.24 down Mm.88796 Plf2 93883_at K03235 proliferin 27857 0.47527 1.23 up Mm.101670 Mm.101670 93004_r_at AI842887 Mus musculus, Similar to hypothetical protein FLJ13055, clone MGC:254927858 0.47529 1.28 down Mm.24471 AA409766 94662_at AA409766 expressed sequence AA4097667859 0.47531 1.53 up Mm.87109 Tpk1 93849_at AB027568 thiamin pyrophosphokinase7860 0.47533 1.60 up Mm.4745 Ksr 92765_s_at AI664600 kinase suppressor of ras7861 0.47550 1.85 up Mm.29804 AU016300 97391_at AW012196 expressed sequence AU0163007862 0.47559 1.77 up Mm.867 Scya12 93717_at U50712 small inducible cytokine A127863 0.47563 1.55 up Mm.5060 Zfp92 101172_at U47104 zinc finger protein 927864 0.47566 1.34 down Mm.4038 Fxr1h 161884_r_at AV368725 fragile X mental retardation gene 1, autosomal homolog7865 0.47573 1.18 down Mm.21126 AI447817 160130_at AA795284 expressed sequence AI4478177866 0.47575 1.36 up Mm.4008 Ccnf 99073_at Z47766 cyclin F7867 0.47592 1.53 up Mm.2438 Wnt6 103735_at M89800 wingless-related MMTV integration site 67868 0.47595 1.48 up Mm.4753 Thrb 98795_at U15548 thyroid hormone receptor beta7869 0.47611 1.29 down Mm.23884 1300011P19Rik 103680_at AA683850 RIKEN cDNA 1300011P19 gene7870 0.47643 1.12 down Mm.1090 Gpx1 94132_at X03920 glutathione peroxidase 17871 0.47656 1.80 up Mm.30107 Pon1 96895_at U32684 paraoxonase 17872 0.47658 1.52 up Mm.7512 Prlpb 93628_at AF015563 prolactin-like protein B7873 0.47676 1.58 up Mm.16730 Ngfa 94773_at X01801 nerve growth factor, alpha7874 0.47687 1.32 down Mm.3935 Ddx24 161933_r_at AV326833 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 13 (RNA helicase A)7875 0.47689 1.93 up Mm.2854 Tff1 162320_at AV072208 trefoil factor 17876 0.47689 1.38 up Mm.29815 Mm.29815 160362_at AW124835 Mus musculus, clone MGC:6545 IMAGE:2655444, mRNA, complete cds7877 0.47690 1.17 down Mm.3128 Pitpn 160409_at U96725 phosphatidylinositol transfer protein7878 0.47696 1.29 down Mm.23564 Bet1 101401_at AF007552 blocked early in transport 1 homolog (S. cerevisiae)7879 0.47717 1.44 up Mm.14158 Tbr1 102700_at U49251 T-box brain gene 17880 0.47718 1.22 up Mm.44552 Txnrd1 99985_at AB027565 thioredoxin reductase 17881 0.47721 1.43 up Mm.21173 2310015N07Rik 103874_r_at AA684456 RIKEN cDNA 2310015N07 gene7882 0.47736 1.21 up Mm.41479 Gnrpx-pending 92197_r_at X83733 guanine nucleotide releasing protein x7883 0.47778 1.58 down Mm.3507 Nr4a2 92248_at U86783 nuclear receptor subfamily 4, group A, member 27884 0.47778 1.47 down Mm.153842 Ptgir 98811_at D26157 prostaglandin I receptor (IP)7885 0.47782 1.21 down Mm.20387 1500015N03Rik 103643_at AI844784 RIKEN cDNA 1500015N03 gene7886 0.47783 1.48 up Mm.12194 Psmd3 161674_i_at AV248657 proteasome (prosome, macropain) 26S subunit, non-ATPase, 37887 0.47797 1.27 down Mm.24718 Rbmxrt 160192_at AF031568 RNA binding motif protein, X chromosome retrogene7888 0.47799 1.35 up Mm.30841 Cacna2d1 104510_at U73487 calcium channel, voltage-dependent, alpha2/delta subunit 17889 0.47801 1.39 up Mm.6239 Pdyn 161987_at AV382264 prodynorphin7890 0.47803 1.58 down Mm.421 Mm.421 98294_at AI530483 ESTs7891 0.47813 1.51 up Mm.20152 AI451340 103603_at AI841401 expressed sequence AI4513407892 0.47813 1.22 down Mm.4954 Siat8b 100474_at X99646 sialyltransferase 8 (alpha-2, 8-sialytransferase) B7893 0.47837 1.48 up Mm.7331 Pbx3 93615_at AF020200 pre B-cell leukemia transcription factor 37894 0.47855 1.52 up Mm.16563 Ldh3 93103_at M17587 lactate dehydrogenase 3, C chain, sperm specific7895 0.47856 1.30 down Mm.18603 Hdc 93328_at X57437 histidine decarboxylase cluster7896 0.47864 1.54 up Mm.43677 Apoa2 161924_f_at AV038316 apolipoprotein A-II7897 0.47878 1.19 down Mm.3545 Ica1 162422_r_at AV290932 islet cell autoantigen 1, 69 kDa7898 0.47886 1.43 up Mm.56965 Evi1 99391_at M21829 ecotropic viral integration site 17899 0.47901 1.52 down Mm.42670 Mm.42670 102118_at C76020 ESTs, Highly similar to T00353 hypothetical protein KIAA0697 [H.sapiens]7900 0.47938 1.19 down Mm.10808 Rw1-pending 102336_at AF060565 RW1 protein7901 0.47995 1.32 up Mm.5046 Ptprj 92986_g_at D83203 protein tyrosine phosphatase, receptor type, J7902 0.47999 1.50 up Mm.7087 Rab5ep-pending 101381_at D86066 rabaptin 57903 0.48008 1.45 up Mm.5010 Zfp29 101166_at X55126 zinc finger protein 297904 0.48013 1.52 up Mm.8771 Pip5k2a 162503_f_at AV159979 phosphatidylinositol-4-phosphate 5-kinase, type II, alpha7905 0.48028 1.96 up Mm.4736 Rai1 98791_at D29801 retinoic acid induced 17906 0.48044 1.25 up Mm.12775 AI035637 92810_at AI842259 expressed sequence AI0356377907 0.48057 1.28 up Mm.14601 Gstm2 161357_r_at AV207739 glutathione S-transferase, mu 27908 0.48078 1.13 up Mm.35687 Casp7 98498_at D86353 caspase 77909 0.48100 1.23 up Mm.27903 6330407G11Rik 97267_at AI844771 RIKEN cDNA 6330407G11 gene7910 0.48119 1.23 up Mm.22633 Dgat1 104371_at AF078752 diacylglycerol O-acyltransferase 17911 0.48141 1.23 down Mm.41433 Dffa 160866_at AI182272 DNA fragmentation factor, alpha subunit7912 0.48142 1.38 up Mm.5290 Pop3-pending 102881_at AI182917 popeye 37913 0.48155 1.44 up Mm.12900 F5 102748_at U52925 coagulation factor V7914 0.48169 1.59 up Mm.28170 Rela 162042_i_at AV375524 v-rel reticuloendotheliosis viral oncogene homolog A, (avian)7915 0.48187 1.39 down Mm.14012 D2Ertd544e 102687_at AI035967 DNA segment, Chr 2, ERATO Doi 544, expressed7916 0.48188 1.48 up Mm.2832 Zfp28 100724_at M36516 zinc finger protein 287917 0.48189 1.11 down Mm.196586 Cul2 96232_at AI854281 cullin 27918 0.48202 1.34 up Mm.6594 Clca3 100623_at AB017156 chloride channel calcium activated 37919 0.48221 1.15 down Mm.30217 Cibkip-pending 96957_at AB006463 calcium and integrin binding, protein kinase interacting protein7920 0.48224 1.34 up Mm.4177 Ucp1 161422_f_at AV294354 uncoupling protein 1, mitochondrialPage 88 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description7921 0.48225 1.22 down Mm.2966 Idh2 95693_at U51167 isocitrate dehydrogenase 2 (NADP+), mitochondrial7922 0.48230 1.43 up Mm.1850 BB219290 95284_at AI662509 expressed sequence BB2192907923 0.48242 1.52 up Mm.4974 Ncam1 100152_at X15050 neural cell adhesion molecule 17924 0.48250 1.27 up Mm.2598 Ppap2a 98508_s_at D84376 phosphatidic acid phosphatase 2a7925 0.48272 1.28 up Mm.22594 AI646709 104361_at AI837260 expressed sequence AI6467097926 0.48275 1.18 up 97747_r_at X668617927 0.48305 1.27 down Mm.27841 0610010O12Rik 97242_at AI849011 RIKEN cDNA 0610010O12 gene7928 0.48307 1.49 up Mm.30377 H2-D4 101652_i_at X52914 histocompatibility 2, D region locus 47929 0.48318 1.36 up Mm.5718 C78549 99438_at C78549 expressed sequence C785497930 0.48319 1.55 up Mm.451 Akr1b3 100067_at D32250 aldo-keto reductase family 1, member B3 (aldose reductase)7931 0.48321 1.45 up Mm.3503 Krtap8-2 97152_at D86422 keratin associated protein 8-27932 0.48325 1.28 up 98770_at AF0127087933 0.48338 1.67 up Mm.182574 2610034N03Rik 161957_r_at AV364085 RIKEN cDNA 2610034N03 gene7934 0.48356 1.61 up Mm.1372 Pde6b 94701_at X55968 phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide7935 0.48420 1.19 down Mm.14530 Rab1 92882_at Y00094 RAB1, member RAS oncogene family7936 0.48423 1.17 up Mm.1141 Hdgf 92629_f_at D63707 hepatoma-derived growth factor7937 0.48430 1.30 up Mm.3107 Nfatc3 161162_at AV233152 nuclear factor of activated T-cells, cytoplasmic 37938 0.48436 1.14 down Mm.28746 Gtr2 98950_at AB017616 small GTPase, homolog (S. cerevisiae)7939 0.48439 1.18 up Mm.41562 2610002K22Rik 99151_at AI849679 RIKEN cDNA 2610002K22 gene7940 0.48440 1.24 down 94277_at U662577941 0.48459 1.37 up 101120_at AA5177317942 0.48460 1.27 up Mm.1209 Sspn 102378_at U02487 sarcospan7943 0.48467 1.09 down Mm.4996 Arf5 92968_at D87902 ADP-ribosylation factor 57944 0.48469 1.47 down Mm.1420 Btn1a1 102708_at U67065 butyrophilin, subfamily 1, member A17945 0.48469 1.23 down Mm.201534 AU020229 98169_s_at AU020229 expressed sequence AU0202297946 0.48483 1.15 down Mm.29968 Rab3d 95442_at AI835706 RAB3D, member RAS oncogene family7947 0.48484 1.24 up Mm.29960 AI326906 97414_at AI852022 expressed sequence AI3269067948 0.48496 1.22 down Mm.21287 AW538196 103890_at AW050153 expressed sequence AW5381967949 0.48497 1.44 down Mm.33941 Amy1 101058_at J00356 amylase 1, salivary7950 0.48507 1.81 up Mm.23758 1110008P04Rik 162185_i_at AV368379 RIKEN cDNA 1110008P04 gene7951 0.48508 1.31 down Mm.18625 Aqp1 93330_at L02914 aquaporin 17952 0.48539 1.13 down Mm.28492 D2Ertd391e 98875_at AW121160 DNA segment, Chr 2, ERATO Doi 391, expressed7953 0.48543 1.44 up Mm.29927 AA408278 161355_f_at AV204036 expressed sequence AA4082787954 0.48567 1.55 up Mm.29590 Idh3b 95676_at AI838061 isocitrate dehydrogenase 3 (NAD+) beta7955 0.48576 1.52 up Mm.36562 AA517562 97190_f_at AA516724 EST AA5175627956 0.48593 1.21 down Mm.206786 Tor1b 162430_at AV294852 torsin family 1, member B7957 0.48603 1.21 down Mm.193073 Mm.193073 103978_at AA666669 Mus musculus, Similar to KIAA0663 gene product, clone MGC:6929 IMAGE:7958 0.48605 1.21 up Mm.180763 Rap1ga1 160822_at AI853638 Rap1, GTPase-activating protein 17959 0.48630 1.68 up Mm.10026 Fsp27 102016_at M61737 fat specific gene 277960 0.48636 1.14 up Mm.218790 Tcf7l2 97660_s_at AJ223070 transcription factor 7-like 2, T-cell specific, HMG-box7961 0.48671 1.12 up Mm.175035 0610038D11Rik 96956_at AW125526 RIKEN cDNA 0610038D11 gene7962 0.48673 1.22 down Mm.10019 Scap2 102012_at AB014485 src family associated phosphoprotein 27963 0.48696 1.21 up Mm.181765 AI848081 160709_at AI788201 expressed sequence AI8480817964 0.48697 1.76 up Mm.57077 Mgat3 99423_at L39373 mannoside acetyl glucosaminyltransferase 37965 0.48699 1.30 down Mm.157091 Adcy6 102321_at M93422 adenylate cyclase 67966 0.48700 1.18 up Mm.30166 2810034J18Rik 97922_at AW045597 RIKEN cDNA 2810034J18 gene7967 0.48717 1.14 up Mm.22565 9130011J15Rik 94286_at AW050340 RIKEN cDNA 9130011J15 gene7968 0.48747 1.62 up Mm.183025 Rbm14 162067_at AV278092 RNA binding motif protein 147969 0.48749 1.23 up Mm.7906 Pin1 101492_at AW047032 protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 17970 0.48768 1.61 down Mm.3639 AW121686 97188_at AW121686 expressed sequence AW1216867971 0.48770 1.56 up Mm.42139 Tectb 98301_at X99806 tectorin beta7972 0.48771 1.22 down Mm.1023 Mm.1023 102225_at AA163268 ESTs7973 0.48800 1.22 up Mm.14814 Abcb3 102873_at U60091 ATP-binding cassette, sub-family B (MDR/TAP), member 37974 0.48811 1.38 up 160083_at M633357975 0.48815 1.18 down Mm.30053 1110002B05Rik 96862_at AI848584 RIKEN cDNA 1110002B05 gene7976 0.48844 1.22 down Mm.6787 Sfrs3 101003_at X53824 splicing factor, arginine/serine-rich 3 (SRp20)7977 0.48849 1.73 up Mm.4073 Acrbp 161720_r_at AV262173 proacrosin binding protein7978 0.48868 1.84 up Mm.24675 AA517631 95925_at AA517631 expressed sequence AA5176317979 0.48877 1.13 up Mm.30179 Mm.30179 96934_at AW049074 ESTs7980 0.48879 1.37 down Mm.90710 6-Sep 92462_at AB023622 septin 67981 0.48885 1.27 up Mm.757 Arha2 101111_at AF014371 ras homolog A27982 0.48893 1.15 down Mm.9811 2310008M10Rik 160569_at AI848235 RIKEN cDNA 2310008M10 gene7983 0.48897 1.16 up Mm.3771 Ptprr 92303_at D31898 protein tyrosine phosphatase, receptor type, R7984 0.48905 1.17 down Mm.3358 U2af2 98404_at X64587 U2 small nuclear ribonucleoprotein auxiliary factor (U2AF), 65 kDa7985 0.48916 1.26 down Mm.14744 Sdcbp 93017_at AF077527 syndecan binding protein7986 0.48951 1.40 up Mm.129578 Mm.129578 162270_r_at AV363683 Mus musculus, Similar to BCL2-associated athanogene 2, clone MGC:287867987 0.48956 1.16 down Mm.5624 Ddx16 100559_at AI853344 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 167988 0.48967 1.39 up Mm.25583 C75939 96513_at AA794350 expressed sequence C759397989 0.48978 1.53 down Mm.1258 Tnfrsf1a 161194_r_at AV252882 tumor necrosis factor receptor superfamily, member 1a7990 0.48982 1.48 down Mm.7588 Srprb 101114_at U17343 signal recognition particle receptor, B subunit7991 0.48990 1.28 down Mm.20931 Gosr1 103293_at AF079901 golgi SNAP receptor complex member 17992 0.48996 1.11 down Mm.22121 D7Ertd156e 104140_s_at AI846989 DNA segment, Chr 7, ERATO Doi 156, expressed7993 0.49002 1.38 up Mm.243 Lama1 103729_at M36775 laminin, alpha 17994 0.49002 1.36 down Mm.57092 Sprr3 101762_at Y09227 small proline-rich protein 37995 0.49008 1.45 up Mm.41881 2900002K07Rik 99514_at AI835443 RIKEN cDNA 2900002K07 gene7996 0.49009 1.39 up Mm.41462 Stx6 99146_at AW124355 syntaxin 67997 0.49027 1.55 down Mm.201606 AI325109 100615_at X04405 expressed sequence AI3251097998 0.49041 1.28 up Mm.23810 D19363 99708_at D19363 expressed sequence D193637999 0.49078 1.46 up Mm.24929 Mm.24929 95858_at C76988 ESTs8000 0.49080 1.22 up Mm.206669 AA545208 104522_at AI047617 expressed sequence AA5452088001 0.49080 1.49 up Mm.206737 Adir 161277_r_at AV290846 ATP-dependant interferon responsive8002 0.49087 1.26 down Mm.5547 C76907 93190_at AW209179 expressed sequence C769078003 0.49090 1.28 up Mm.14644 Tsn 93012_at X81464 translin8004 0.49104 1.33 up Mm.28440 Pthlh 104262_at M60057 parathyroid hormone-like peptide8005 0.49116 1.25 up Mm.24564 2810432L12Rik 95440_at AI846093 RIKEN cDNA 2810432L12 gene8006 0.49119 1.14 up Mm.29810 2600001H07Rik 96245_at AW124530 RIKEN cDNA 2600001H07 gene8007 0.49129 1.20 down Mm.7381 Hig1-pending 101094_at AI836820 hypoxia induced gene 18008 0.49134 1.21 up Mm.27880 Cugbp2 97255_at AW061318 CUG triplet repeat,RNA binding protein 28009 0.49160 1.36 up Mm.24724 Ppp1r3c 93933_at U89924 protein phosphatase 1, regulatory (inhibitor) subunit 3C8010 0.49171 1.51 up Mm.56979 Bmp5 99393_at L41145 bone morphogenetic protein 5Page 89 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description8011 0.49175 1.16 down Mm.29793 1700028N03Rik 97387_at AI847879 RIKEN cDNA 1700028N03 gene8012 0.49176 1.22 up Mm.28027 Rbl2 95617_at U36799 retinoblastoma-like 28013 0.49198 1.09 down Mm.2147 Ctsd 93810_at X68378 cathepsin D8014 0.49206 1.59 up Mm.20995 1700029H17Rik 103847_at L04848 RIKEN cDNA 1700029H17 gene8015 0.49207 1.31 up Mm.56941 Olfr15 98011_at AL078630 olfactory receptor 158016 0.49210 1.62 down Mm.195098 Tuba-rs1 101315_at M19413 tubulin alpha, related sequence 18017 0.49212 1.32 up Mm.182434 1700066C05Rik 160584_at AI838704 RIKEN cDNA 1700066C05 gene8018 0.49213 1.41 up Mm.12876 Cmkar3 94173_at AF045146 chemokine (C-X-C) receptor 38019 0.49218 1.18 up Mm.25180 Mm.25180 103934_at AA673769 Mus musculus, Similar to solute carrier family 6 (neurotransmitter transporter8020 0.49240 1.38 up Mm.21579 H2bfs 93834_at M25487 H2B histone family, member S8021 0.49241 1.12 down Mm.26949 D9Ertd394e 96112_at AI851178 DNA segment, Chr 9, ERATO Doi 394, expressed8022 0.49241 1.67 up Mm.24153 0610009A07Rik 103714_at AI265638 RIKEN cDNA 0610009A07 gene8023 0.49254 1.71 up Mm.116802 Nfatc2 93074_g_at U36576 nuclear factor of activated T-cells, cytoplasmic 28024 0.49265 1.16 up Mm.21892 2610005L19Rik 104105_at AI854665 RIKEN cDNA 2610005L19 gene8025 0.49274 1.18 up Mm.23684 Axin 160701_at AF009011 axin8026 0.49288 1.49 up Mm.86787 Mm.86787 100307_at AA002843 ESTs, Weakly similar to simple repeat sequence-containing transcript [Mus8027 0.49289 1.32 up Mm.30049 C1qbp 96856_at AJ001101 complement component 1, q subcomponent binding protein8028 0.49292 1.23 down Mm.21911 1810038D15Rik 94034_at AI839882 RIKEN cDNA 1810038D15 gene8029 0.49303 1.17 up Mm.38497 Pml 99015_at U33626 promyelocytic leukemia8030 0.49321 1.74 up Mm.25 Gas2 94338_g_at M21828 growth arrest specific 28031 0.49322 1.29 up Mm.4834 Hyal2 100447_at AJ000059 hyaluronidase 28032 0.49333 1.23 down Mm.25366 C80612 102875_at AI840487 expressed sequence C806128033 0.49364 1.51 up Mm.23526 2610036L13Rik 160699_at AI877184 RIKEN cDNA 2610036L13 gene8034 0.49374 1.65 up Mm.57094 Fgf2 93216_at AF065903 fibroblast growth factor 28035 0.49376 1.19 down Mm.4633 Snrpa 100101_at L15447 small nuclear ribonucleoprotein polypeptide A8036 0.49391 1.45 up Mm.4988 Rag2 101163_at M64796 recombination activating gene 28037 0.49394 1.37 down Mm.13694 Oat 161278_r_at AV291007 ornithine aminotransferase8038 0.49414 1.15 up Mm.218233 Mm.218233 102969_at AI847369 Mus musculus, Similar to G protein pathway suppressor 2, clone IMAGE:5358039 0.49416 1.14 up Mm.41617 2700099C19Rik 99156_at AI853370 RIKEN cDNA 2700099C19 gene8040 0.49419 1.16 down Mm.2664 Prrg2 94924_at AW122679 proline-rich Gla (G-carboxyglutamic acid) polypeptide 28041 0.49422 1.36 up Mm.10761 Dok2 102334_at AF059583 downstream of tyrosine kinase 28042 0.49432 1.64 up Mm.56990 Ercc2 161572_r_at AV346811 excision repair cross-complementing rodent repair deficiency, complementat8043 0.49444 1.17 down Mm.14534 9130221H12Rik 92884_at AW045468 RIKEN cDNA 9130221H12 gene8044 0.49447 1.14 up Mm.27746 Dscr2 97220_at AW122732 Down syndrome critical region homolog 2 (human)8045 0.49490 1.31 up Mm.5316 Actn3 162164_f_at AV359510 actinin alpha 38046 0.49496 1.23 up Mm.129355 Mm.129355 160392_at AW060358 ESTs, Weakly similar to ADT1 MOUSE ADP,ATP CARRIER PROTEIN, HEA8047 0.49497 1.34 up Mm.1396 Slc30a3 161395_i_at AV262491 solute carrier family 30 (zinc transporter), member 38048 0.49506 1.25 up Mm.22584 Strap 94292_at AF096285 serine/threonine kinase receptor associated protein8049 0.49506 1.43 up Mm.216303 Ntf3 92420_at X53257 neurotrophin 38050 0.49514 1.09 up Mm.41840 Ppp3r1 99183_at AW123013 protein phospatase 3, regulatory subunit B, alpha isoform (calcineurin B, type8051 0.49538 1.20 up Mm.548 Cox6c 100550_f_at AW060422 cytochrome c oxidase, subunit VIc8052 0.49562 1.50 up Mm.4920 Gria1 92943_at X57497 glutamate receptor, ionotropic, AMPA1 (alpha 1)8053 0.49564 1.27 up Mm.200859 Pafah1b2 99023_at U57747 platelet-activating factor acetylhydrolase, isoform 1b, alpha2 subunit8054 0.49568 1.30 up Mm.8728 Aqp7 101859_at AB010100 aquaporin 78055 0.49579 1.24 up Mm.12481 Cetn3 92788_f_at Y12474 centrin 38056 0.49601 1.17 up Mm.4603 Srb1 100095_at U37799 scavenger receptor class B18057 0.49651 1.20 up Mm.140013 Dnm1l 160931_at AW120468 dynamin 1-like8058 0.49662 1.53 up Mm.193395 6330580J24Rik 161766_i_at AV336102 RIKEN cDNA 6330580J24 gene8059 0.49667 1.23 down Mm.22745 Oprs1 94828_at AF004927 opioid receptor, sigma 18060 0.49671 1.81 up Mm.34943 Mm.34943 97143_at C79450 ESTs8061 0.49704 1.16 up Mm.2469 Shfdg1 95456_r_at U41626 split hand/foot deleted gene 18062 0.49705 1.35 down Mm.29088 0610013D04Rik 96118_at AF110520 RIKEN cDNA 0610013D04 gene8063 0.49710 1.13 up Mm.27663 Tceb3 95536_at AB025015 transcription elongation factor B (SIII), polypeptide 3 (110kD)8064 0.49725 1.34 up Mm.16193 Muc1 93716_at U16175 mucin 1, transmembrane8065 0.49726 1.14 down Mm.153758 0610040H15Rik 160402_at AA795613 RIKEN cDNA 0610040H15 gene8066 0.49762 1.12 up Mm.1457 Ddah2 92887_at AF004106 dimethylarginine dimethylaminohydrolase 28067 0.49767 1.43 down Mm.181959 Egr1 161802_i_at AV369921 early growth response 18068 0.49781 1.40 up Mm.3841 Cox8b 161205_at AV260484 cytochrome c oxidase, subunit VIIIb8069 0.49799 1.24 up Mm.4236 Bcap29 160876_at X78684 B-cell receptor-associated protein 298070 0.49803 1.19 down Mm.40321 4631434O19Rik 94801_at AI607332 RIKEN cDNA 4631434O19 gene8071 0.49806 1.31 up Mm.41970 Drd2 97776_at X55674 dopamine receptor 28072 0.49830 1.34 up Mm.18154 Tcl1 93296_at Y15376 T-cell lymphoma breakpoint 18073 0.49836 1.22 down Mm.4628 Smpd1 100099_at Z14132 sphingomyelin phosphodiesterase 1, acid lysosomal8074 0.49847 1.30 up Mm.30199 Csnk1e 97925_at AB028241 casein kinase 1, epsilon8075 0.49852 1.40 up Mm.1752 Sox5 102954_at AJ010604 SRY-box containing gene 58076 0.49910 1.81 down Mm.56965 Evi1 100754_at X54989 ecotropic viral integration site 18077 0.49916 1.19 down Mm.29868 Atp6g1 96281_at AW121246 ATPase, H+ transporting, lysosomal (vacuolar proton pump)8078 0.49919 1.45 up Mm.3988 Sil 92367_at U36778 Tal1 interrupting locus8079 0.49925 1.36 up Mm.30482 Hils1 160404_at AA110326 histone H1-like protein in spermatids 18080 0.49937 1.21 down Mm.196397 D11Ertd333e 100041_at AW124133 DNA segment, Chr 11, ERATO Doi 333, expressed8081 0.49945 1.47 down Mm.24001 Mef2c 104592_i_at AI595996 myocyte enhancer factor 2C8082 0.49958 1.14 down Mm.219659 Hist2 93068_r_at U62674 histone gene complex 28083 0.49977 1.22 down Mm.21921 Borg4-pending 94036_at AI844806 binder of Rho GTPase 48084 0.49981 1.13 down Mm.24719 Arl6ip2 104745_at AA763874 ADP-ribosylation-like factor 6 interacting protein 28085 0.49985 1.71 up Mm.22126 Fabp1 94075_at Y14660 fatty acid binding protein 1, liver8086 0.50001 1.42 up Mm.2550 Agpt 96510_at U83509 angiopoietin8087 0.50003 1.25 up Mm.3680 D14Wsu146e 98977_at AI835044 DNA segment, Chr 14, Wayne State University 146, expressed8088 0.50008 1.12 up Mm.30072 Cox7a2l 160383_at X80899 cytochrome c oxidase subunit VIIa polypeptide 2-like8089 0.50011 1.27 up Mm.7598 hr 99875_at Z32675 hairless8090 0.50027 1.45 up Mm.22062 Cpeb 160680_at Y08260 cytoplasmic polyadenylation element binding protein8091 0.50041 1.33 up Mm.42251 Krt2-18 99569_at AF021836 keratin complex 2, basic, gene 188092 0.50046 1.49 up Mm.1274 Krc 94149_at L07911 kappa B and Rss recognition component8093 0.50053 1.10 down Mm.41326 Gbl-pending 98513_at AI851821 G protein beta subunit-like8094 0.50055 1.30 up Mm.57246 Mycs 102581_at AB016289 myc-like oncogene, s-myc protein8095 0.50059 1.16 down Mm.88295 Crry 161648_at AV087550 complement receptor related protein8096 0.50066 1.10 up Mm.203937 AA960555 96774_at AW047139 expressed sequence AA9605558097 0.50066 1.35 up Mm.30377 H2-D4 101653_f_at X52914 histocompatibility 2, D region locus 48098 0.50067 1.09 up Mm.41098 Hs1bp3-pending 92411_at AJ132192 HS1 binding protein 38099 0.50071 1.49 up Mm.7184 Muc3 101390_at AF027131 mucin 3, in<strong>test</strong>inal8100 0.50079 1.17 up Mm.22649 R74815 103514_at AI850244 expressed sequence R74815Page 90 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description8101 0.50086 1.11 up Mm.35854 2610507B11Rik 98538_at X81632 RIKEN cDNA 2610507B11 gene8102 0.50090 1.30 down Mm.141020 MGC6279 96763_at AI839995 hypothetical protein MGC62798103 0.50106 1.35 up Mm.138529 4733401O11Rik 97111_at AA290180 RIKEN cDNA 4733401O11 gene8104 0.50118 1.15 up Mm.24499 3100002J04Rik 95435_at AI844009 RIKEN cDNA 3100002J04 gene8105 0.50164 1.90 up Mm.27039 1110032N12Rik 161762_at AV303374 RIKEN cDNA 1110032N12 gene8106 0.50165 1.71 up Mm.27291 Bysl 96644_at AF007802 bystin-like8107 0.50166 1.32 down Mm.219461 Fgd1 93674_at U22325 faciogenital dysplasia homolog8108 0.50204 1.09 down Mm.29269 2410001H17Rik 95090_at AA688600 RIKEN cDNA 2410001H17 gene8109 0.50237 1.41 up Mm.29937 2310044H10Rik 162139_r_at AV344835 RIKEN cDNA 2310044H10 gene8110 0.50243 1.13 up Mm.179252 Nd1-pending 97302_at AI854285 Nd18111 0.50272 1.54 down Mm.156955 Ivl 92739_at L28819 involucrin8112 0.50293 1.45 up Mm.16857 Cdc25c 102935_at U15562 cell division cycle 25 homolog C (S. cerevisiae)8113 0.50305 1.18 up Mm.15974 1810030O07Rik 161169_f_at AV237921 RIKEN cDNA 1810030O07 gene8114 0.50307 1.30 up Mm.1387 Rab11a 96238_at AI853996 RAB11a, member RAS oncogene family8115 0.50308 1.39 up Mm.28733 D14Ertd817e 96223_at AW048854 DNA segment, Chr 14, ERATO Doi 817, expressed8116 0.50316 1.30 up Mm.5044 Bmp8a 92982_at M97017 bone morphogenetic protein 8a8117 0.50321 1.22 down Mm.24944 Mm.24944 95961_at AW122131 ESTs, Weakly similar to FAN MOUSE PROTEIN FAN [M.musculus]8118 0.50323 1.44 up Mm.25362 Hox11l2 103948_at AJ223801 homeo box 11-like 28119 0.50326 1.37 up Mm.20857 Zfp125 103268_r_at AI154710 zinc finger protein 1258120 0.50343 1.22 down Mm.435 2410004N11Rik 99940_at AW212667 RIKEN cDNA 2410004N11 gene8121 0.50344 1.30 up Mm.1247 Pcsk2 102296_at M55669 proprotein convertase subtilisin/kexin type 28122 0.50357 1.26 up Mm.3815 Sdc4 98590_at D89571 syndecan 48123 0.50366 1.23 up Mm.28048 0610038H10Rik 160765_at AW120781 RIKEN cDNA 0610038H10 gene8124 0.50369 1.38 up Mm.3907 Slc6a4 99040_at X66119 solute carrier family 6 (neurotransmitter transporter, serotonin), member 48125 0.50379 1.18 down Mm.27182 1110031I02Rik 96626_at AI843401 RIKEN cDNA 1110031I02 gene8126 0.50392 1.18 up Mm.88216 Snrpb 160555_r_at M58761 small nuclear ribonucleoprotein B8127 0.50411 1.29 up Mm.25089 Mm.25089 96391_at C80836 ESTs, Weakly similar to MAF2 MOUSE TRANSCRIPTION FACTOR MAF2 [8128 0.50412 1.31 up Mm.788 Ly6e 102570_at U47850 lymphocyte antigen 6 complex, locus E8129 0.50424 1.15 down Mm.29027 Sparcl1 160319_at U66166 SPARC-like 1 (mast9, hevin)8130 0.50426 1.41 up Mm.1358 M6pr 92846_at X64070 mannose-6-phosphate receptor, cation dependent8131 0.50441 1.41 up Mm.10688 Trrp5 97580_at AF029983 transient receptor protein 58132 0.50443 1.12 up Mm.25308 BC004004 95517_i_at AI846338 hypothetical protein, MGC:75508133 0.50444 1.11 down Mm.27477 2010100O12Rik 96686_i_at AI853864 RIKEN cDNA 2010100O12 gene8134 0.50446 1.51 up Mm.26947 Letm1 160222_i_at AI851685 leucine zipper-EF-hand containing transmembrane protein 18135 0.50448 1.19 up Mm.22277 4833412N02Rik 104289_at AI840662 RIKEN cDNA 4833412N02 gene8136 0.50451 1.34 up Mm.5163 Rin 100505_at U71202 RAS-like protein expressed in neuron8137 0.50454 1.84 up Mm.213078 Fv4 101313_r_at U95783 Friend virus susceptibility 48138 0.50478 1.21 down Mm.29618 2310046A13Rik 97347_at AA838868 RIKEN cDNA 2310046A13 gene8139 0.50482 1.23 up Mm.14437 H2-M3 102731_g_at AA163474 histocompatibility 2, M region locus 38140 0.50535 1.19 down Mm.5728 Adprt2 100903_at AJ007780 ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 28141 0.50552 1.30 up Mm.88062 Tex271 101875_at X81059 <strong>test</strong>is expressed gene 2718142 0.50553 1.27 up Mm.16745 Oxt 94775_at M88355 oxytocin8143 0.50559 1.42 down Mm.22840 Mm.22840 95372_at AA217469 ESTs8144 0.50559 1.43 down Mm.39527 Mm.39527 101696_r_at AI837271 EST8145 0.50576 1.49 up Mm.30438 Tyrp1 97956_g_at X59513 tyrosinase-related protein 18146 0.50582 1.49 up Mm.28623 Mm.28623 96203_at AI847646 Mus musculus, clone IMAGE:4241711, mRNA, partial cds8147 0.50585 1.16 down Mm.1620 Anxa5 93083_at D63423 annexin A58148 0.50589 1.29 up Mm.21539 D1Ucla3 93824_at AI182073 DNA segment, Chr 1, University of California at Los Angeles 38149 0.50590 1.26 down Mm.28412 Mms19l 162400_f_at AV277003 MMS19 (MET18 S. cerevisiae)-like8150 0.50615 1.50 up Mm.4409 Mcpt2 99958_at J05177 mast cell protease 28151 0.50620 1.49 up Mm.3572 1110033J19Rik 98149_s_at AW046496 RIKEN cDNA 1110033J19 gene8152 0.50633 1.46 up Mm.2935 4631408O11Rik 161813_i_at AV374401 RIKEN cDNA 4631408O11 gene8153 0.50648 1.21 up Mm.133825 0610010I23Rik 101593_at AI851454 RIKEN cDNA 0610010I23 gene8154 0.50648 1.24 up Mm.27289 1600023A02Rik 96643_at AW121336 RIKEN cDNA 1600023A02 gene8155 0.50653 1.22 up Mm.12607 Lmo1 102413_at AW124311 LIM only 18156 0.50669 1.18 up Mm.30001 5730434I03Rik 96351_at AI846097 RIKEN cDNA 5730434I03 gene8157 0.50671 1.43 up Mm.4193 Mm.4193 101116_at AA511245 EST8158 0.50696 1.48 down Mm.41639 Mm.41639 92378_at AI849305 Mus musculus, clone IMAGE:3590815, mRNA, partial cds8159 0.50699 1.25 down Mm.2746 Gstt1 95019_at X98055 glutathione S-transferase, theta 18160 0.50703 1.17 down Mm.39061 Adss2 99039_g_at L24554 adenylosuccinate synthetase 2, non muscle8161 0.50708 1.39 up Mm.4636 Neurod1 92717_at U28068 neurogenic differentiation 18162 0.50711 1.12 down Mm.39081 Taf1a 92339_at Y09972 TATA box binding protein (Tbp)-associated factor, RNA polymerase I, A8163 0.50713 1.32 up Mm.4661 Hegfl 92730_at L07264 heparin binding epidermal growth factor-like growth factor8164 0.50721 1.35 up Mm.29205 Brunol4 93147_f_at AI839880 bruno-like 4, RNA binding protein (Drosophila)8165 0.50745 1.09 up Mm.179409 1700030K07Rik 93046_at AW045233 RIKEN cDNA 1700030K07 gene8166 0.50764 1.48 up Mm.35664 D2Ertd97e 161675_f_at AV169168 DNA segment, Chr 2, ERATO Doi 97, expressed8167 0.50772 1.17 down Mm.41401 AA589632 95625_at AI840149 expressed sequence AA5896328168 0.50774 1.57 up Mm.21108 1110061B18Rik 161714_f_at AV250133 RIKEN cDNA 1110061B18 gene8169 0.50781 1.58 up Mm.180150 Ube2v2 161725_r_at AV266107 ubiquitin-conjugating enzyme E2 variant 28170 0.50825 1.35 up Mm.27446 Siat7d 96682_at Y15780 sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-ace8171 0.50827 1.35 up Mm.10081 Gli 94097_at AB025922 GLI-Kruppel family member GLI8172 0.50829 1.63 up Mm.1241 Kcna5 102295_at L22218 potassium voltage-gated channel, shaker-related subfamily, member 58173 0.50837 1.47 up Mm.620 Arsa 100931_at X73230 arylsulfatase A8174 0.50840 1.30 down Mm.3395 1110003B01Rik 160837_at AA036386 RIKEN cDNA 1110003B01 gene8175 0.50842 1.25 up Mm.34150 Slc2a5 160839_at AI606956 solute carrier family 2 (facilitated glucose transporter), member 58176 0.50843 1.22 up Mm.28494 Mrpl11 98876_at AI854160 mitochondrial ribosomal protein L118177 0.50850 1.28 up Mm.6118 AI790646 161257_r_at AV321519 expressed sequence AI7906468178 0.50862 1.53 up Mm.197785 C80388 96571_at C80388 expressed sequence C803888179 0.50863 1.29 up Mm.12267 MGC6685 92774_at AA068153 similar to poly(A)-binding protein, cytoplasmic 4 (inducible form)8180 0.50864 1.38 down Mm.10094 Es2el 160574_at AF037256 expressed sequence 2 embryonic lethal8181 0.50877 1.49 down Mm.66489 D14Ertd114e 161697_r_at AV232600 DNA segment, Chr 14, ERATO Doi 114, expressed8182 0.50882 1.15 down Mm.28684 Mm.28684 96217_at AW060552 Mus musculus, Similar to DNA polymerase beta, clone MGC:6386 IMAGE:358183 0.50885 1.43 up Mm.19669 Pfkfb3 103577_at AI326331 inducible 6-phosphofructo-2-kinase8184 0.50896 1.30 up Mm.218749 Cyp2b10 102701_at M21856 cytochrome P450, 2b10, phenobarbitol inducible, type b8185 0.50910 1.21 down Mm.131074 C030048H19Rik 92525_i_at AW122114 RIKEN cDNA C030048H19 gene8186 0.50928 1.20 down Mm.2074 Ly75 103258_at U19271 lymphocyte antigen 758187 0.50939 1.26 up Mm.154298 4931417M11Rik 99138_at AA756292 RIKEN cDNA 4931417M11 gene8188 0.50942 1.37 up Mm.18041 Calm2 161523_r_at AV225659 calmodulin 28189 0.50942 1.34 up Mm.214684 Mm.214684 99436_at X17018 Mus musculus sialophorin (Spn), mRNA8190 0.50946 1.20 down Mm.29063 2410022L05Rik 96779_f_at AI846315 RIKEN cDNA 2410022L05 genePage 91 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description8281 0.51822 1.25 up Mm.4763 Mdfi 100433_r_at U57820 MyoD family inhibitor8282 0.51831 1.38 up Mm.4342 Tjp1 162298_r_at AV023208 tight junction protein 18283 0.51849 1.84 up Mm.104747 Igk-V28 101331_f_at U55641 immunoglobulin kappa chain variable 28 (V28)8284 0.51857 1.28 up Mm.3508 Barx2 100736_at L77900 BarH-like homeobox 28285 0.51872 1.36 up Mm.42143 Ma2a8 98303_at X79131 antigen identified by monoclonal antibody 2A88286 0.51882 1.45 up Mm.5135 Grik2 98863_at X66117 glutamate receptor, ionotropic, kainate 2 (beta 2)8287 0.51883 1.33 up Mm.57250 Hic1 104462_at AW048074 hypermethylated in cancer 18288 0.51887 1.17 down Mm.196340 Slc31a1 101877_at AI854432 solute carrier family 31, member 18289 0.51901 1.18 down Mm.29697 1300006C19Rik 95702_at AI461803 RIKEN cDNA 1300006C19 gene8290 0.51910 1.17 up Mm.43162 0710008D09Rik 99618_at AI853523 RIKEN cDNA 0710008D09 gene8291 0.51913 1.12 down Mm.24867 Stx4a 103781_at U76832 syntaxin 4A (placental)8292 0.51944 1.44 up Mm.56921 Obp1a 99377_at Y10971 odorant binding protein Ia8293 0.51959 1.20 down Mm.137885 Plod3 160742_at AI840146 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 38294 0.51965 1.14 up Mm.7103 Pbx2 101382_at AF020198 pre B-cell leukemia transcription factor 28295 0.51966 1.16 down Mm.489 Tsbp 100460_at L49502 TPR-containing, SH2-binding phosphoprotein8296 0.51968 1.13 up Mm.200771 C87820 103081_at AA863928 expressed sequence C878208297 0.51969 1.59 up Mm.29904 Mrpl15 161630_i_at AV041981 mitochondrial ribosomal protein L158298 0.51983 1.17 up Mm.34002 Mm.34002 98039_at AI853819 Mus musculus partial mRNA for sr104 protein8299 0.51990 1.18 down Mm.43081 Mapk8ip3 160880_at AB005662 mitogen-activated protein kinase 8 interacting protein 38300 0.51993 1.17 down Mm.21795 Mm.21795 104088_at AW060311 ESTs, Highly similar to I38863 E1B 19K/Bcl-2-interacting protein Nip1 [H.sap8301 0.51996 1.16 up Mm.196614 Eef1a1 94766_at M17878 eukaryotic translation elongation factor 1 alpha 18302 0.52001 1.27 up Mm.21787 2900042B11Rik 104085_at AI852970 RIKEN cDNA 2900042B11 gene8303 0.52039 1.37 down Mm.93826 Mm.93826 161620_f_at AV355545 ESTs8304 0.52046 1.43 down Mm.13052 Kap 94199_at M22810 kidney androgen regulated protein8305 0.52053 1.36 up Mm.25760 Prdc-pending 103975_at AB011030 protein related to DAN and cerberus8306 0.52060 1.29 up Mm.202653 AI132487 94440_at AI173533 expressed sequence AI1324878307 0.52067 1.40 up Mm.4264 Epha6 101122_at U58332 Eph receptor A68308 0.52071 1.47 up Mm.30988 Mfi2 97970_at AB024336 antigen p97 (melanoma associated) identified by monoclonal antibodies 1338309 0.52087 1.36 up Mm.4668 Mpo 100415_at X15378 myeloperoxidase8310 0.52087 1.41 up Mm.37203 Pl2 98568_at M85067 placental lactogen 28311 0.52093 1.15 down Mm.15607 Vegfb 103001_at U43836 vascular endothelial growth factor B8312 0.52130 1.40 up Mm.40615 Kcnq2 99449_at AB000497 potassium voltage-gated channel, subfamily Q, member 28313 0.52133 1.20 up Mm.30015 AW547365 97425_at AI840191 expressed sequence AW5473658314 0.52135 1.15 up Mm.20938 Wbp4 103836_at AF071184 WW domain binding protein 48315 0.52138 1.33 up Mm.57223 Hells 93228_at U25691 helicase, lymphoid specific8316 0.52139 1.22 up Mm.2879 Grik5 162074_r_at AV326295 glutamate receptor, ionotropic, kainate 5 (gamma 2)8317 0.52174 1.28 up Mm.27668 Mm.27668 95539_at AA798971 ESTs, Moderately similar to I57546 Rabin3 - rat [R.norvegicus]8318 0.52187 1.41 up Mm.24748 Mm.24748 95930_at AA536727 ESTs8319 0.52196 1.34 up Mm.1572 AI448995 94759_at AI448995 expressed sequence AI4489958320 0.52207 1.37 up Mm.1280 Spt1 94153_g_at M33974 salivary protein 18321 0.52212 1.47 up Mm.4932 Hoxd1 98819_at M87802 homeo box D18322 0.52222 1.39 up Mm.196638 Rab6kifl 160501_at Y09632 Rab6, kinesin-like8323 0.52230 1.27 up Mm.21138 Nufip1 103868_at AA681274 nuclear fragile X mental retardation protein interacting protein8324 0.52232 1.41 up Mm.44488 1110031K21Rik 95375_r_at AI413993 RIKEN cDNA 1110031K21 gene8325 0.52239 1.21 up Mm.4832 Pitx1 92920_at U71206 paired-like homeodomain transcription factor 18326 0.52240 1.25 down Mm.29088 0610013D04Rik 102267_at AF110520 RIKEN cDNA 0610013D04 gene8327 0.52243 1.22 up Mm.2745 Ctrl 160744_r_at AA244542 chymotrypsin-like8328 0.52247 1.13 down Mm.89958 Mrvi1 97112_at AI157017 MRV integration site 18329 0.52265 1.14 up Mm.34411 Mm.34411 100977_at AA691492 Mus musculus, Similar to pyruvate dehydrogenase kinase, isoenzyme 1, clon8330 0.52277 1.13 up Mm.22353 1810029F08Rik 104302_f_at AI851085 RIKEN cDNA 1810029F08 gene8331 0.52306 1.09 up Mm.196029 Stat3 99099_at U08378 signal transducer and activator of transcription 38332 0.52309 1.51 up Mm.34935 D1Ertd75e 97140_at C77922 DNA segment, Chr 1, ERATO Doi 75, expressed8333 0.52317 1.29 up Mm.20451 Sult4a1 94564_at AF059257 sulfotransferase family 4A, member 18334 0.52326 1.20 up Mm.18213 Tgfb2 93300_at X57413 transforming growth factor, beta 28335 0.52328 1.30 up Mm.31239 D2Bwg1335e 160408_at AI838900 DNA segment, Chr 2, Brigham & Women's Genetics 1335 expressed8336 0.52331 1.18 up Mm.57245 Hsp70-2 96564_at X54401 heat shock protein, 70 kDa 28337 0.52332 1.38 up Mm.24138 Cd44 103005_s_at X66084 CD44 antigen8338 0.52353 1.23 up Mm.135 Cln3 102659_at U68064 ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)8339 0.52360 1.29 up Mm.21964 AU016842 103746_at AA797843 expressed sequence AU0168428340 0.52387 1.39 up Mm.16525 Plk 93099_f_at U01063 polo-like kinase homolog, (Drosophila)8341 0.52397 1.28 up Mm.22637 0910001L24Rik 104372_at AI836883 RIKEN cDNA 0910001L24 gene8342 0.52401 1.56 down Mm.24069 Fem1b 160656_i_at AF064448 feminization 1 homolog b (C. elegans)8343 0.52405 1.44 up Mm.20425 Bsn 95317_at Y17034 bassoon8344 0.52408 1.65 up Mm.30717 Synj2 100676_at AF026123 synaptojanin 28345 0.52416 1.40 up Mm.6375 Gyg1 100597_at AW049730 glycogenin 18346 0.52423 1.25 down Mm.7983 Grid1 94619_at D10171 glutamate receptor, ionotropic, delta 18347 0.52426 1.72 down Mm.28131 BC005682 162116_r_at AV368721 hypothetical protein, MGC: 116138348 0.52445 1.12 down Mm.200161 D4Ertd296e 93238_at AI846822 DNA segment, Chr 4, ERATO Doi 296, expressed8349 0.52465 1.15 down Mm.646 Tpm2 100605_at M81086 tropomyosin 2, beta8350 0.52516 1.48 up Mm.2974 Fbp2 97379_at D42083 fructose bisphosphatase 28351 0.52518 1.20 up Mm.28562 Syt5 104269_at AB026806 synaptotagmin 58352 0.52533 1.34 down Mm.28597 2010003P03Rik 96201_at AW123978 RIKEN cDNA 2010003P03 gene8353 0.52542 1.22 up Mm.196417 Ascl2 101355_at U77628 achaete-scute complex homolog-like 2 (Drosophila)8354 0.52567 1.22 down Mm.214959 BB128963 93235_at AI020029 expressed sequence BB1289638355 0.52571 1.20 up Mm.31308 Entpd2 97986_at U91511 ectonucleoside triphosphate diphosphohydrolase 28356 0.52574 1.30 up Mm.27357 AU015843 160229_at AI846667 expressed sequence AU0158438357 0.52595 1.46 up Mm.4870 Snap91 100455_at M83985 synaptosomal-associated protein, 91 kDa8358 0.52611 1.28 down Mm.20305 Hoxc5 95312_at U28071 homeo box C58359 0.52619 1.45 up Mm.7290 Mm.7290 99867_at AI506277 ESTs8360 0.52621 1.20 down Mm.24972 Mvp 103793_at AI874858 major vault protein8361 0.52621 1.23 down Mm.37395 Mm.37395 98569_at AA690218 Mus musculus, clone MGC:36388 IMAGE:5098924, mRNA, complete cds8362 0.52631 1.23 up Mm.23894 Dhodh 161397_r_at AV272809 dihydroorotate dehydrogenase8363 0.52642 1.34 up Mm.4848 Fyn 100133_at M27266 Fyn proto-oncogene8364 0.52651 1.23 down Mm.38792 Nsdhl 98631_g_at AW106745 NAD(P) dependent steroid dehydrogenase-like8365 0.52652 1.13 up Mm.28128 2310066N05Rik 97802_at AI850195 RIKEN cDNA 2310066N05 gene8366 0.52666 1.17 down Mm.16366 Mtcp1 103044_g_at Z35294 mature T-cell proliferation 18367 0.52686 1.21 down Mm.35815 Rock2 98504_at U58513 Rho-associated coiled-coil forming kinase 28368 0.52728 1.25 up Mm.86933 2900008M13Rik 162080_f_at AV331477 RIKEN cDNA 2900008M13 gene8369 0.52732 1.38 down Mm.218317 4930553M18Rik 94476_at AA672926 RIKEN cDNA 4930553M18 gene8370 0.52752 1.41 up Mm.24876 Elf1 160721_at U19617 E74-like factor 1Page 93 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description8371 0.52774 1.48 up Mm.25030 4733401D09Rik 160984_r_at AI835031 RIKEN cDNA 4733401D09 gene8372 0.52787 1.14 up Mm.2184 2510048O06Rik 94014_at AA760073 RIKEN cDNA 2510048O06 gene8373 0.52799 1.12 down Mm.154511 C79379 96628_at X54327 expressed sequence C793798374 0.52802 1.33 up Mm.1114 Gla 102341_at L46651 galactosidase, alpha8375 0.52810 1.31 up Mm.1627 Mm.1627 94765_at AA050528 ESTs8376 0.52813 1.47 up Mm.1121 Lor 162324_at AV083081 loricrin8377 0.52815 1.47 down Mm.20115 Dao1 103602_at D10210 D-amino acid oxidase8378 0.52824 1.49 up Mm.21099 Mm.21099 103303_at AA798246 ESTs8379 0.52826 1.56 down Mm.12090 Gli2 100395_at X99104 GLI-Kruppel family member GLI28380 0.52834 1.35 down Mm.27953 D19Wsu57e 95603_at AW123955 DNA segment, Chr 19, Wayne State University 57, expressed8381 0.52838 1.19 down Mm.5039 Six2 98839_at X80338 sine oculis-related homeobox 2 homolog (Drosophila)8382 0.52841 1.43 up Mm.4092 Wnt7b 92404_at M89802 wingless-related MMTV integration site 7B8383 0.52847 1.40 up Mm.200415 Fbs 101325_r_at U20239 fibrosin8384 0.52851 1.59 up Mm.154879 Nmu 161032_i_at AI850277 neuromedin8385 0.52884 1.15 down Mm.24426 Sec23a 104709_at AI843665 SEC23A (S. cerevisiae)8386 0.52904 1.22 up Mm.3146 Tcf20 100947_at AI847906 transcription factor 208387 0.52929 1.23 up Mm.20836 Apaf1 103796_at AF064071 apoptotic protease activating factor 18388 0.52944 1.46 up Mm.22279 Casp8ap2 104291_at AA982672 caspase 8 associated protein 28389 0.52970 1.16 up Mm.87864 Cdc2l1 95805_at M58633 cell division cycle 2 homolog (S. pombe)-like 18390 0.52983 1.55 down Mm.3862 Igf2 98622_at X71922 insulin-like growth factor 28391 0.52987 1.58 down Mm.200752 Muc5b 101803_at AJ010792 mucin 5, subtype B, tracheobronchial8392 0.53018 1.10 up Mm.25412 0610011H20Rik 94373_at AA269903 RIKEN cDNA 0610011H20 gene8393 0.53025 1.45 up Mm.29982 Rpl31 96339_at AW048363 ribosomal protein L318394 0.53029 1.59 up Mm.20442 Lrrc6 160952_r_at AF092208 leucine-rich repeat-containing 6 (<strong>test</strong>is)8395 0.53035 1.62 up Mm.18502 Osbpl1a 93317_at W35700 oxysterol binding protein-like 1A8396 0.53038 1.62 down Mm.6306 Atp2a3 93404_g_at U49393 ATPase, Ca++ transporting, ubiquitous8397 0.53045 1.51 up Mm.146332 C87808 161207_at AV261982 expressed sequence C878088398 0.53051 1.14 up Mm.122494 Mm.122494 161895_s_at AV103742 Mus musculus, similar to CG6734 gene product (H. sapiens), clone MGC:328399 0.53066 1.15 up Mm.26994 Rab25 160731_at AI893677 RAB25, member RAS oncogene family8400 0.53087 1.24 up Mm.4137 Chga 162192_f_at AV371732 chromogranin A8401 0.53098 1.30 down Mm.25074 Hnrpc 160199_at AF095257 heterogeneous nuclear ribonucleoprotein C8402 0.53108 1.36 up Mm.218521 Mm.218521 161237_at AV279825 Mus musculus, clone MGC:28589 IMAGE:4212192, mRNA, complete cds8403 0.53123 1.27 up Mm.10305 Hyal1 102230_at AF011567 hyaluronidase 18404 0.53144 1.62 up Mm.34483 Mm.34483 161402_r_at AV277198 ESTs, Weakly similar to C52B9.3.p [Caenorhabditis elegans] [C.elegans]8405 0.53145 1.45 up Mm.8014 Enam 94623_at U82698 enamelin8406 0.53163 1.24 up Mm.202157 1810073P09Rik 95952_at AW124781 RIKEN cDNA 1810073P09 gene8407 0.53168 1.22 up Mm.42011 Foxh1 97789_at AF069303 forkhead box H18408 0.53182 1.48 up Mm.22478 Smarcf1 104329_at AI842326 SWI/SNF related, matrix associated, actin dependent regulator of chromatin,8409 0.53188 1.42 up Mm.4406 Mmp9 99957_at X72795 matrix metalloproteinase 98410 0.53194 1.19 down Mm.3781 Piga 161433_f_at AV308550 phosphatidylinositol glycan, class A8411 0.53202 1.24 down Mm.6478 AW546647 93424_at AI836915 expressed sequence AW5466478412 0.53205 1.19 up Mm.925 Tfdp1 101958_f_at X72310 transcription factor Dp 18413 0.53208 1.18 up Mm.22288 Ccnd1 94232_at AI849928 cyclin D18414 0.53209 1.08 up Mm.22365 Ets2 94246_at J04103 E26 avian leukemia oncogene 2, 3' domain8415 0.53224 1.28 up Mm.909 Dsc1 100760_at X97986 desmocollin 18416 0.53234 1.43 up 101566_f_at M178188417 0.53238 1.32 up Mm.28370 AU021979 160778_at AI846236 expressed sequence AU0219798418 0.53252 1.21 down Mm.3140 Mpdz 93887_at AI854351 multiple PDZ domain protein8419 0.53259 1.23 up Mm.14663 Atp5l 93014_at Y17223 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g8420 0.53260 1.15 down Mm.9684 Vasp 101982_at X98475 vasodilator-stimulated phosphoprotein8421 0.53291 1.27 down Mm.41560 Serpini1 99494_at AJ001700 serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 18422 0.53292 1.09 down Mm.176845 1110069M14Rik 96305_at AI845854 RIKEN cDNA 1110069M14 gene8423 0.53308 1.21 down Mm.195498 Slc25a17 103347_at AI852548 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein8424 0.53313 1.25 down Mm.4360 Cd19 99945_at M28240 CD19 antigen8425 0.53318 1.46 up Mm.29475 2810052M02Rik 95150_at AI852196 RIKEN cDNA 2810052M02 gene8426 0.53347 1.47 up Mm.3732 Mail-pending 161903_f_at AV374591 molecule possessing ankyrin-repeats induced by lipopolysaccharide8427 0.53359 1.61 up Mm.828 Rag1 93683_at M29475 recombination activating gene 18428 0.53395 1.21 up Mm.3948 1110034C02Rik 99100_at AI837104 RIKEN cDNA 1110034C02 gene8429 0.53430 1.30 up Mm.5269 R75531 161061_r_at AA793086 expressed sequence R755318430 0.53444 1.53 up Mm.28081 Tead1 161383_r_at AV248036 TEA domain family member 18431 0.53445 1.33 up Mm.34879 AI316859 98468_r_at AI316859 expressed sequence AI3168598432 0.53467 1.39 up Mm.215512 Mm.215512 161087_r_at AV170591 EST8433 0.53471 1.13 down Mm.30264 Mm.30264 160825_at AI850707 ESTs, Moderately similar to T46399 hypothetical protein DKFZp434N2420.18434 0.53472 1.19 up Mm.35389 Cycs 98132_at X01756 cytochrome c, somatic8435 0.53481 1.14 down Mm.201501 AI427892 161064_f_at AI427892 expressed sequence AI4278928436 0.53481 1.29 up Mm.3860 Ryk 161548_r_at AV244126 receptor-like tyrosine kinase8437 0.53486 1.31 down Mm.14595 Csf2rb1 94748_g_at M34397 colony stimulating factor 2 receptor, beta 1, low-affinity (granulocyte-macroph8438 0.53517 1.27 up Mm.3529 Cappa2 98127_at U16741 capping protein alpha 28439 0.53525 1.21 down Mm.18641 Pte1 103386_at AW046123 peroxisomal acyl-CoA thioesterase 18440 0.53541 1.11 down Mm.21104 Mm.21104 103863_at AW049769 Mus musculus, Similar to CG5104 gene product, clone MGC:8112 IMAGE:358441 0.53545 1.50 up Mm.11746 C80008 160945_at AI597025 expressed sequence C800088442 0.53574 1.30 up Mm.2903 Prim1 96772_at J04620 DNA primase, p49 subunit8443 0.53576 1.13 up Mm.203700 AU017197 96518_at AU017197 expressed sequence AU0171978444 0.53579 1.48 up Mm.982 Edg1 101953_at AF108019 endothelial differentiation sphingolipid G-protein-coupled receptor 18445 0.53583 1.17 down Mm.20929 Herc2 103829_at AF061529 hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RC8446 0.53588 1.44 down Mm.23118 1300008P06Rik 162090_i_at AV318239 RIKEN cDNA 1300008P06 gene8447 0.53591 1.16 up Mm.29460 Ak2 95148_at AB020202 adenylate kinase 28448 0.53600 1.10 down Mm.28931 Mm.28931 96560_at AA648027 ESTs8449 0.53608 1.30 up Mm.14486 D2Ertd542e 92878_at AI848388 DNA segment, Chr 2, ERATO Doi 542, expressed8450 0.53615 1.35 down Mm.4965 Lhx1 92961_at Z27410 LIM homeobox protein 18451 0.53623 1.42 down Mm.6676 Api6 93445_at AF011428 apoptosis inhibitory 68452 0.53644 1.58 down 97049_at AF0052768453 0.53649 1.13 down Mm.193073 Mm.193073 94845_at AW125736 Mus musculus, Similar to KIAA0663 gene product, clone MGC:6929 IMAGE:8454 0.53675 1.44 up Mm.12885 Dach1 94179_at AJ005669 dachshund 1 (Drosophila)8455 0.53685 1.27 down Mm.29429 3110038L01Rik 95135_at AI844396 RIKEN cDNA 3110038L01 gene8456 0.53712 1.30 up Mm.218348 AW212720 160745_at AW049299 expressed sequence AW2127208457 0.53722 1.46 up Mm.4424 Cacna1b 98360_at U04999 calcium channel, voltage-dependent, N type, alpha 1B subunit8458 0.53729 1.58 up Mm.41978 Siat6 97778_at X84234 sialyltransferase 6 (N-acetyllacosaminide alpha 2,3-sialyltransferase)8459 0.53732 1.35 up Mm.5237 Ddef1 161139_f_at AV175719 development and differentiation enhancing8460 0.53750 1.14 up Mm.200373 Sgpl1 96127_at AW048730 sphingosine phosphate lyase 1Page 94 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description8461 0.53753 1.28 down Mm.10117 Xin 102213_at AF051945 cardiac morphogenesis8462 0.53762 1.14 up Mm.31130 Mm.31130 98344_f_at AI850438 ESTs, Moderately similar to VIS3 MOUSE VISININ-LIKE PROTEIN 3 [M.mus8463 0.53768 1.26 up Mm.21915 2610318K02Rik 94035_at AI849961 RIKEN cDNA 2610318K02 gene8464 0.53770 1.23 up Mm.2523 Myt1l 96495_at U86338 myelin transcription factor 1-like8465 0.53780 1.10 down Mm.28919 Dstn 94492_at AB025406 destrin8466 0.53790 1.16 up Mm.3401 Pcsk5 92194_at D17583 proprotein convertase subtilisin/kexin type 58467 0.53793 1.23 down Mm.30837 Ndrl 96596_at U52073 N-myc downstream regulated-like8468 0.53794 1.26 down Mm.16976 Taf9 103073_i_at AI842969 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor8469 0.53802 1.19 down Mm.99776 Xpnpep1 101591_at AI852589 cytosolic aminopeptidase P8470 0.53828 1.38 down Mm.46269 Ins1 97658_f_at X04725 insulin I8471 0.53847 1.32 up Mm.29422 Glrb 104449_at X81202 glycine receptor, beta subunit8472 0.53853 1.13 down Mm.55 Trim27 100553_at L46855 tripartite motif protein 278473 0.53868 1.52 up Mm.27579 2900062L11Rik 95523_at AI839718 RIKEN cDNA 2900062L11 gene8474 0.53882 1.37 up Mm.6083 Mm.6083 93370_at AW046243 ESTs8475 0.53920 1.40 up Mm.5019 Serpinb2 92978_s_at X16490 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 28476 0.53920 1.21 down Mm.23210 Mm.23210 95385_at AI643119 ESTs8477 0.53933 1.19 down Mm.21864 2310075E07Rik 104100_at AI845915 RIKEN cDNA 2310075E07 gene8478 0.53964 1.26 up Mm.10563 Mtf2 103658_r_at AI836552 metal response element binding transcription factor 28479 0.53964 1.34 up Mm.5045 Slc16a2 162219_f_at AV150997 solute carrier family 16 (monocarboxylic acid transporters), member 28480 0.53972 1.45 up Mm.203915 AI132321 162043_i_at AV375706 expressed sequence AI1323218481 0.53984 1.28 up Mm.200650 R74981 161271_r_at AV321362 expressed sequence R749818482 0.54016 1.35 down Mm.8637 Spa17 101850_at Z46299 sperm autoantigenic protein 178483 0.54071 1.25 down Mm.2921 Prkcq 104431_at D11091 protein kinase C, theta8484 0.54072 1.15 down Mm.21556 AW107884 93829_at AW107884 expressed sequence AW1078848485 0.54087 1.40 down Mm.644 Mef2b 93418_g_at D50311 myocyte enhancer factor 2B8486 0.54094 1.29 up Mm.2986 AW146116 96275_f_at AI843327 expressed sequence AW1461168487 0.54113 1.17 up Mm.29114 Gnpat 94562_at AI843968 glyceronephosphate O-acyltransferase8488 0.54131 1.30 up Mm.1635 Pias3 93708_at AF034080 protein inhibitor of activated STAT 38489 0.54132 1.32 down Mm.27463 AI851288 104190_at AI851288 expressed sequence AI8512888490 0.54155 1.60 up Mm.218286 AA516734 99576_at AA516734 expressed sequence AA5167348491 0.54157 1.26 down Mm.27643 Smoc1 96712_at AI848508 secreted modular calcium binding protein 18492 0.54163 1.29 up Mm.29271 Nat6 104439_at AI840198 N-acetyltransferase 68493 0.54169 1.32 up Mm.5098 Gli3 101182_at X95255 GLI-Kruppel family member GLI38494 0.54170 1.32 down Mm.28040 1500036F01Rik 97297_at AI841858 RIKEN cDNA 1500036F01 gene8495 0.54171 1.24 up Mm.38875 Mlsn1 102251_at AF047714 melastatin 18496 0.54176 1.48 up Mm.615 Igh-Ia 99829_at M29011 immunoglobulin heavy chain Ia8497 0.54177 1.34 up Mm.6220 Adam7 101626_at AF013107 a disintegrin and metalloprotease domain 78498 0.54182 1.18 up Mm.8156 Rad51ap1 93676_at U93583 RAD51 associated protein 18499 0.54183 1.36 up Mm.4827 F7 92918_at U66079 coagulation factor VII8500 0.54186 1.16 down Mm.42085 Elf4 98289_at AF016714 E74-like factor 4 (ets domain transcription factor)8501 0.54198 1.27 up Mm.23961 3110023F10Rik 104578_f_at AI195392 RIKEN cDNA 3110023F10 gene8502 0.54209 1.26 up Mm.5085 Six4 92999_at D50416 sine oculis-related homeobox 4 homolog (Drosophila)8503 0.54215 1.15 down Mm.200250 AI317167 104427_at AA930526 expressed sequence AI3171678504 0.54254 1.21 up Mm.31123 C78960 161111_f_at AV238668 expressed sequence C789608505 0.54263 1.19 up Mm.27570 Ndufa6 160237_at AW047339 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6 (14kD, B14)8506 0.54264 1.24 down Mm.27541 Ube2a 96695_at AF089812 ubiquitin-conjugating enzyme E2A, RAD6 homolog (S. cerevisiae)8507 0.54273 1.15 down Mm.18856 Mapk6 103416_at AI844810 mitogen-activated protein kinase 68508 0.54276 1.34 down Mm.40752 Usp29 96433_at AA673236 ubiquitin specific protease 298509 0.54278 1.48 up Mm.1893 1810004I06Rik 93359_at AI839743 RIKEN cDNA 1810004I06 gene8510 0.54289 1.16 up Mm.5234 Mm.5234 161056_at AW045596 ESTs, Weakly similar to A48830 probable transcription regulator NT fin12 - m8511 0.54289 1.24 up Mm.12891 Zfp326 102309_at AB012725 zinc finger protein 3268512 0.54296 1.24 down Mm.14460 Akr1b7 161918_at AV380611 aldo-keto reductase family 1, member B78513 0.54321 1.18 up Mm.12896 Dll3 102746_at AF068865 delta-like 3 (Drosophila)8514 0.54332 1.19 down Mm.25121 Acatn 160201_r_at AB016795 acetyl-Coenzyme A transporter8515 0.54343 1.18 up Mm.27070 C85514 160732_at AA726383 expressed sequence C855148516 0.54346 1.44 down Mm.36520 Ggps1 98970_at AB016044 geranylgeranyl diphosphate synthase 18517 0.54354 1.40 down Mm.196242 Spi2 92583_at D00725 serine protease inhibitor 28518 0.54358 1.19 up Mm.1406 Npm3 102796_at U64450 nucleoplasmin 38519 0.54370 1.46 up Mm.28161 Zfp36l2 93943_f_at M58564 zinc finger protein 36, C3H type-like 28520 0.54394 1.11 down Mm.24808 Fxyd6 95473_s_at AW123338 FXYD domain-containing ion transport regulator 68521 0.54408 1.21 up Mm.41555 AW496496 99493_at AI842066 expressed sequence AW4964968522 0.54412 1.19 up Mm.28278 Cav 97849_at U07645 caveolin, caveolae protein, 22 kDa8523 0.54414 1.26 up Mm.56899 Klrc1 99370_at AF095447 killer cell lectin-like receptor subfamily C, member 18524 0.54426 1.36 up Mm.5574 Mm.5574 101223_r_at C77112 EST8525 0.54432 1.33 up Mm.1703 Tubb5 161673_r_at AV145175 tubulin, beta 58526 0.54433 1.15 up Mm.41479 Gnrpx-pending 92196_f_at X83733 guanine nucleotide releasing protein x8527 0.54435 1.23 up Mm.15512 Kcnab2 162182_f_at AV012348 potassium voltage-gated channel, shaker-related subfamily, beta member 28528 0.54442 1.33 up Mm.58 Itgb7 162193_f_at AV371872 integrin beta 78529 0.54446 1.16 down Mm.2404 Ptpn16 104598_at X61940 protein tyrosine phosphatase, non-receptor type 168530 0.54460 1.32 up Mm.4163 Dsc2 97768_at L33779 desmocollin 28531 0.54489 1.47 up Mm.1616 Ctf1 161479_f_at AV054675 cardiotrophin 18532 0.54510 1.20 up Mm.34374 2200008D09Rik 160421_r_at AA590358 RIKEN cDNA 2200008D09 gene8533 0.54516 1.19 up Mm.6358 Mm.6358 93408_at AI850482 ESTs, Moderately similar to T09222 exocyst complex protein Exo84 - rat [R.8534 0.54539 1.15 down Mm.21126 AI447817 104611_at AI854008 expressed sequence AI4478178535 0.54546 1.33 up Mm.29658 9430096L06Rik 97360_at AI841689 RIKEN cDNA 9430096L06 gene8536 0.54549 1.22 down Mm.28452 0610007H10Rik 160294_at AI843539 RIKEN cDNA 0610007H10 gene8537 0.54552 1.16 down Mm.148007 1110012J22Rik 94290_at AW124346 RIKEN cDNA 1110012J22 gene8538 0.54554 1.12 up Mm.26422 Copg1 96936_at AI020792 coatomer protein complex, subunit gamma 18539 0.54556 1.24 down Mm.21579 H2bfs 93889_f_at X90778 H2B histone family, member S8540 0.54561 1.28 up Mm.3911 Adam10 100751_at AF011379 a disintegrin and metalloprotease domain 108541 0.54561 1.21 up Mm.35784 Sox3 92264_at X94125 SRY-box containing gene 38542 0.54570 1.17 up Mm.253 AA536646 160206_at AI663783 expressed sequence AA5366468543 0.54580 1.49 up Mm.28604 Mm.28604 162368_r_at AV239112 ESTs8544 0.54601 1.30 up Mm.27202 Crygd 162268_at AV361541 crystallin, gamma D8545 0.54605 1.36 up Mm.144413 Ucp2 92792_at U69135 uncoupling protein 2, mitochondrial8546 0.54608 1.56 down Mm.34377 Camk2d 93214_at AF059029 calcium/calmodulin-dependent protein kinase II, delta8547 0.54635 1.21 up Mm.22233 Psmb2 94219_at AI853269 proteasome (prosome, macropain) subunit, beta type 28548 0.54642 1.08 down Mm.4337 Ei24 99629_at AW060710 etoposide induced 2.4 mRNA8549 0.54646 1.10 up Mm.3845 D6Ertd109e 98608_at AI845886 DNA segment, Chr 6, ERATO Doi 109, expressed8550 0.54649 1.21 up Mm.27463 AI851288 104189_at AI122079 expressed sequence AI851288Page 95 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description8551 0.54660 1.45 up Mm.43213 9030402K04Rik 161579_r_at AV313455 RIKEN cDNA 9030402K04 gene8552 0.54674 1.15 up Mm.142105 1200003O06Rik 94549_at AI315650 RIKEN cDNA 1200003O06 gene8553 0.54688 1.16 down Mm.3544 Cacnb3 98483_at X94404 calcium channel, voltage-dependent, beta 3 subunit8554 0.54700 1.25 down Mm.20477 Uty 95337_at AF057367 ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome8555 0.54714 1.25 up Mm.42083 Plcb1 92467_g_at U85714 phospholipase C, beta 18556 0.54742 1.14 down Mm.197816 Mm.197816 93419_at AW215863 Mus musculus, Similar to hypothetical protein FLJ22405, clone MGC:192908557 0.54756 1.17 up Mm.4420 Ptpn21 99970_at D37801 protein tyrosine phosphatase, non-receptor type 218558 0.54775 1.16 down Mm.21110 AA408683 160661_at AI840615 expressed sequence AA4086838559 0.54782 1.17 down Mm.34410 Ruvbl2 160422_at AB013912 RuvB-like protein 28560 0.54788 1.17 up Mm.24750 Pr-pending 95465_s_at AI849587 voltage-dependent calcium channel gamma subunit-like protein8561 0.54802 1.61 up Mm.143805 Mtlrp-pending 160873_at AV206059 motilin-related peptide8562 0.54817 1.42 up Mm.28252 1110018O12Rik 161830_f_at AV025277 RIKEN cDNA 1110018O12 gene8563 0.54848 1.30 down Mm.57013 Nek4 93210_g_at AJ223071 NIMA (never in mitosis gene a)-related expressed kinase 48564 0.54850 1.24 up Mm.3336 1110007C09Rik 160835_i_at AI851695 RIKEN cDNA 1110007C09 gene8565 0.54850 1.08 up 161063_r_at AI0487468566 0.54861 1.37 up Mm.8437 Ambn 93692_f_at U65021 ameloblastin8567 0.54862 1.16 up Mm.3111 Rpl28 100727_at X74856 ribosomal protein L288568 0.54866 1.26 down Mm.25232 Itga6 95511_at X69902 integrin alpha 68569 0.54869 1.36 up Mm.22747 1110068J02Rik 103521_r_at AI197008 RIKEN cDNA 1110068J02 gene8570 0.54871 1.25 down Mm.107441 Zfp26 102277_at M36514 zinc finger protein 268571 0.54874 1.17 up Mm.7387 Rpo1-4 93620_at AF000938 RNA polymerase 1-4 (194 kDa subunit)8572 0.54881 1.22 up Mm.22608 AI747712 104363_at AA763213 expressed sequence AI7477128573 0.54892 1.34 down Mm.28626 2410018G23Rik 98919_at AA867773 RIKEN cDNA 2410018G23 gene8574 0.54905 1.56 up Mm.8016 Dub2 99905_at U70368 deubiquitinating enzyme 28575 0.54906 1.22 down Mm.9122 Pon3 93940_at L76193 paraoxonase 38576 0.54915 1.16 down Mm.23992 Mm.23992 103694_at AW125432 Mus musculus, Similar to KIAA0169 protein, clone IMAGE:5323473, mRNA,8577 0.54922 1.14 down Mm.35127 1110025I09Rik 98125_at AI849193 RIKEN cDNA 1110025I09 gene8578 0.54928 1.45 up Mm.203968 1810015H18Rik 99605_at AA536968 RIKEN cDNA 1810015H18 gene8579 0.54930 1.44 down Mm.20448 Fut9 95328_at AB015426 fucosyltransferase 98580 0.54934 1.44 up Mm.10696 Nrg1 98313_at AB025413 neuregulin 18581 0.54944 1.18 up Mm.29344 Tde1l 95101_at AI834772 tumor differentially expressed 1, like8582 0.54968 1.44 up Mm.157743 Ddx6 93964_s_at AF038995 DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 68583 0.54970 1.14 up Mm.20309 1110039O14Rik 93560_at AI845882 RIKEN cDNA 1110039O14 gene8584 0.54974 1.39 up Mm.6735 Prep 161459_f_at AV301321 prolyl endopeptidase8585 0.54976 1.15 up Mm.30263 Facl5 97456_at AI838021 fatty acid Coenzyme A ligase, long chain 58586 0.54977 1.14 down Mm.27568 6530403D07Rik 104362_at AI853532 RIKEN cDNA 6530403D07 gene8587 0.54979 1.40 down Mm.1280 Spt1 162108_f_at AV293232 salivary protein 18588 0.54994 1.23 down Mm.9326 Rnf13 101965_at AF037205 ring finger protein 138589 0.55003 1.21 up Mm.5048 Mcmd5 162102_r_at AV291335 mini chromosome maintenance deficient 5 (S. cerevisiae)8590 0.55009 1.60 up Mm.1389 Nfatc2ip 100699_at U76759 nuclear factor of activated T-cells, cytoplasmic 2 interacting protein8591 0.55013 1.25 up Mm.25071 Mm.25071 95999_at C80518 ESTs8592 0.55040 1.15 up Mm.24255 Tle3 104623_at X73360 transducin-like enhancer of split 3, homolog of Drosophila E(spl)8593 0.55063 1.33 up Mm.2731 Pemt 161893_i_at AV372813 phosphatidylethanolamine N-methyltransferase8594 0.55064 1.15 up Mm.29631 3830408P06Rik 104463_at AI157789 RIKEN cDNA 3830408P06 gene8595 0.55066 1.10 down Mm.16554 Hdh 102928_at L28827 Huntington disease gene homolog8596 0.55071 1.33 up Mm.23564 Bet1 162495_r_at AV149387 blocked early in transport 1 homolog (S. cerevisiae)8597 0.55077 1.07 up Mm.27990 Mm.27990 97284_at AI853789 Mus musculus, Similar to MIL1 protein, clone MGC:28321 IMAGE:4014844,8598 0.55082 1.16 down Mm.27983 Mln64-pending 95607_at X82457 steroidogenic acute regulatory protein related8599 0.55088 1.23 down Mm.5179 Il12rb2 99323_at U64199 interleukin 12 receptor, beta 28600 0.55104 1.12 down Mm.67 Frg1 100978_at U62105 FSHD region gene 18601 0.55112 1.15 down Mm.22796 2900016D05Rik 104502_f_at AI414025 RIKEN cDNA 2900016D05 gene8602 0.55130 1.20 up Mm.29037 Nubp1 94528_at AI846206 nucleotide binding protein 18603 0.55150 1.52 up Mm.6352 AI449432 100939_at AW123479 expressed sequence AI4494328604 0.55152 1.32 up Mm.8543 Pso 101844_at U94700 peroxisomal sarcosine oxidase8605 0.55156 1.65 up Mm.4227 AA517545 98325_at AA517545 expressed sequence AA5175458606 0.55178 1.21 up Mm.5194 Dlx3 99328_at U79738 distal-less homeobox 38607 0.55201 1.40 down Mm.10661 Slc2a4 162385_i_at AV252545 solute carrier family 2 (facilitated glucose transporter), member 48608 0.55207 1.22 up Mm.27292 D6Wsu157e 96646_at AI846253 DNA segment, Chr 6, Wayne State University 157, expressed8609 0.55226 1.29 up Mm.8471 Per2 93694_at AF036893 period homolog 2 (Drosophila)8610 0.55237 1.22 up Mm.26266 Mm.26266 103994_at AI152867 Mus musculus, eukaryotic translation initiation factor 2C, 2, clone MGC:38668611 0.55244 1.35 up Mm.43640 4921506J03Rik 99163_at AI844232 RIKEN cDNA 4921506J03 gene8612 0.55259 1.08 down Mm.1668 Fmo5 162091_f_at AV318575 flavin containing monooxygenase 58613 0.55263 1.10 down Mm.182951 Psma2 100733_at X70303 proteasome (prosome, macropain) subunit, alpha type 28614 0.55287 1.11 up Mm.25366 C80612 160209_at AI850285 expressed sequence C806128615 0.55290 1.32 up Mm.31387 Nr5a1 101666_at D10584 nuclear receptor subfamily 5, group A, member 18616 0.55303 1.44 up Mm.3193 Pkia 98005_at AW125442 protein kinase inhibitor, alpha8617 0.55307 1.13 down Mm.38868 1300009F09Rik 93993_at AI851062 RIKEN cDNA 1300009F09 gene8618 0.55334 1.18 up Mm.43749 3100001N19Rik 99653_at AI848902 RIKEN cDNA 3100001N19 gene8619 0.55344 1.17 up Mm.182195 3200002M19Rik 161264_f_at AV313633 RIKEN cDNA 3200002M19 gene8620 0.55344 1.31 up Mm.214490 Mm.214490 101823_at X72904 ESTs, Highly similar to S23682 T-cell receptor alpha chain - mouse [M.musc8621 0.55355 1.16 up Mm.3722 Faf1 161364_f_at AV222925 Fas-associated factor 18622 0.55355 1.13 down Mm.2573 Ahcy 96024_at L32836 S-adenosylhomocysteine hydrolase8623 0.55363 1.40 up Mm.21103 D7Wsu128e 103860_at AW209594 DNA segment, Chr 7, Wayne State University 128, expressed8624 0.55371 1.22 up Mm.26730 Hp 96092_at M96827 haptoglobin8625 0.55371 1.15 down Mm.826 Pigf 104725_at AW060401 phosphatidylinositol glycan, class F8626 0.55372 1.10 down Mm.1648 AI553596 94770_at AI553596 expressed sequence AI5535968627 0.55375 1.43 up Mm.4560 Lrpap1 161988_f_at AV234541 low density lipoprotein receptor-related protein associated protein 18628 0.55385 1.32 up Mm.1926 Kcnc1 103208_at Y07521 potassium voltage gated channel, Shaw-related subfamily, member 18629 0.55398 1.57 up Mm.142733 Scn1a 94201_at L42339 sodium channel, voltage-gated, type I, alpha polypeptide8630 0.55405 1.43 up Mm.3924 Cav3 99050_at U36579 caveolin 38631 0.55417 1.64 down Mm.196405 Hsd3b2 101659_at M75886 hydroxysteroid dehydrogenase-2, delta-3-beta8632 0.55418 1.28 up Mm.86453 Aebp2 94869_at AW120832 AE binding protein 28633 0.55430 1.24 down Mm.218494 D3Wsu161e 98016_at AA981268 DNA segment, Chr 3, Wayne State University 161, expressed8634 0.55439 1.33 up Mm.5612 C85189 100558_at AW060241 expressed sequence C851898635 0.55445 1.57 up Mm.2326 Mif 94848_at L39357 macrophage migration inhibitory factor8636 0.55447 1.11 down Mm.25610 4932431F02Rik 96578_r_at AI853019 RIKEN cDNA 4932431F02 gene8637 0.55448 1.22 up Mm.4685 Flg 100420_at J03458 filaggrin8638 0.55475 1.16 up Mm.28311 Mm.28311 96156_at AA874329 ESTs8639 0.55484 1.23 down Mm.31512 Rnf2 97506_at AI043016 ring finger protein 28640 0.55492 1.22 down Mm.28917 1810045K17Rik 96739_at AI852409 RIKEN cDNA 1810045K17 genePage 96 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description8641 0.55493 1.19 down Mm.4428 Mm.4428 162143_f_at AV350479 Mus musculus, clone MGC:31389 IMAGE:4241819, mRNA, complete cds8642 0.55502 1.34 up Mm.3355 Tnfsf6 97113_at U06948 tumor necrosis factor (ligand) superfamily, member 68643 0.55510 1.39 down Mm.196728 Abcg2 93626_at AF103875 ATP-binding cassette, sub-family G (WHITE), member 28644 0.55538 1.11 down Mm.1275 Txn1 92807_at X77585 thioredoxin 18645 0.55542 1.20 down Mm.28553 5730589K01Rik 96197_f_at AI851708 RIKEN cDNA 5730589K01 gene8646 0.55546 1.18 up Mm.29709 Orc6l 95712_at AW045261 origin recognition complex, subunit 6-like (S. cerevisiae)8647 0.55547 1.26 up Mm.27871 2610012O22Rik 97252_at AW120926 RIKEN cDNA 2610012O22 gene8648 0.55547 1.28 down Mm.1689 AI593484 94784_at AI593484 expressed sequence AI5934848649 0.55551 1.34 down Mm.41949 Eya4 92453_at Y17115 eyes absent 4 homolog (Drosophila)8650 0.55556 1.25 up Mm.88819 Syt7 100365_at AB026804 synaptotagmin 78651 0.55557 1.16 down Mm.1032 Hspa4 161745_f_at AV319225 heat shock 70 kDa protein 48652 0.55558 1.36 up Mm.695 Ssh3bp1 101037_at U17698 spectrin SH3 domain binding protein 18653 0.55576 1.25 up Mm.22515 Gpc3 160158_at AI843313 glypican 38654 0.55591 1.12 down Mm.14483 Birc3 102734_at U88909 baculoviral IAP repeat-containing 38655 0.55607 1.30 up Mm.830 Psme1 161293_r_at AV306568 proteasome (prosome, macropain) 28 subunit, alpha8656 0.55611 1.31 up Mm.103863 2810040C05Rik 99006_at C79728 RIKEN cDNA 2810040C05 gene8657 0.55616 1.17 up Mm.1491 Fxyd1 93040_at AF091390 FXYD domain-containing ion transport regulator 18658 0.55624 1.49 up Mm.395 Ptpn8 161848_r_at AV335129 protein tyrosine phosphatase, non-receptor type 88659 0.55630 1.23 up Mm.7106 Bmpr2 99865_at AF003942 bone morphogenic protein receptor, type II (serine/threonine kinase)8660 0.55645 1.17 up Mm.38441 Galnt3 162313_f_at AV055653 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltra8661 0.55651 1.12 up Mm.29605 AU022870 160811_at AW121710 expressed sequence AU0228708662 0.55654 1.34 up Mm.21772 Smarcd2 160675_at M60510 SWI/SNF related, matrix associated, actin dependent regulator of chromatin,8663 0.55675 1.27 down Mm.4801 Prkcl 101148_at D28577 protein kinase C, lambda8664 0.55682 1.24 down Mm.24776 C77118 103770_at AA794189 expressed sequence C771188665 0.55697 1.19 up Mm.148701 Mm.148701 102130_f_at C88243 ESTs, Weakly similar to env polyprotein, retrovirus-related [M.musculus]8666 0.55707 1.21 down Mm.22664 AA407235 104375_at AI844853 expressed sequence AA4072358667 0.55732 1.17 down Mm.35790 Mm.35790 98516_at AI853136 Mus musculus 13 days embryo liver cDNA, RIKEN full-length enriched library8668 0.55744 1.29 up Mm.29927 AA408278 104475_at AW124101 expressed sequence AA4082788669 0.55752 1.66 up Mm.143768 Fbxo3 162451_r_at AV027999 f-box only protein 38670 0.55818 1.12 up Mm.21187 1110005F07Rik 93769_at AI838708 RIKEN cDNA 1110005F07 gene8671 0.55822 1.34 down Mm.3251 Pcsk4 104675_at D01093 proprotein convertase subtilisin/kexin type 48672 0.55824 1.33 down Mm.24886 4833420N02Rik 161756_at AV298145 RIKEN cDNA 4833420N02 gene8673 0.55888 1.36 up Mm.4594 Mybl2 100023_at X70472 myeloblastosis oncogene-like 28674 0.55900 1.48 up Mm.57047 Htr1b 99411_at M85151 5-hydroxytryptamine (serotonin) receptor 1B8675 0.55905 1.24 down Mm.139233 0610042C05Rik 104537_at AW048828 RIKEN cDNA 0610042C05 gene8676 0.55926 1.65 up Mm.196549 Mm.196549 162465_i_at AV062451 Mus musculus, Similar to hypothetical protein DKFZp434G0522, clone MGC8677 0.55933 1.35 down Mm.42152 Fmnl 92483_g_at AF006466 formin-like8678 0.55936 1.19 down Mm.455 Tcf1 161847_r_at AV332839 transcription factor 18679 0.55944 1.16 down Mm.29097 Lims1l 104634_at AA874589 LIM and senescent cell antigen-like domains 1-like8680 0.55946 1.34 up Mm.6370 Miz1 160912_i_at AV375944 Msx-interacting-zinc finger8681 0.55953 1.13 down Mm.830 Psme1 101510_at AB007136 proteasome (prosome, macropain) 28 subunit, alpha8682 0.55988 1.18 down Mm.200673 Lasp1 93793_at AW122780 LIM and SH3 protein 18683 0.55998 1.16 down Mm.29630 Gtf3c1 97354_at AI836082 general transcription factor III C 18684 0.55999 1.26 up Mm.21679 1300002F13Rik 93974_at AW212475 RIKEN cDNA 1300002F13 gene8685 0.56008 1.68 up Mm.27800 1810029G24Rik 161855_at AV056147 RIKEN cDNA 1810029G24 gene8686 0.56012 1.54 up Mm.1590 Mm.1590 94760_at AA177484 ESTs8687 0.56020 1.29 up Mm.31530 Mm.31530 97991_at X02452 Mus musculus, Similar to v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene hom8688 0.56041 1.53 up Mm.5400 Brd7 161290_r_at AV302662 bromodomain-containing 78689 0.56047 1.16 down Mm.28259 4930588M11Rik 160279_at AW123632 RIKEN cDNA 4930588M11 gene8690 0.56053 1.32 up Mm.6476 2700084L22Rik 100955_at AA989957 RIKEN cDNA 2700084L22 gene8691 0.56056 1.26 up Mm.28825 2310038G18Rik 161390_r_at AV256163 RIKEN cDNA 2310038G18 gene8692 0.56056 1.61 down Mm.25231 4932441P04Rik 94355_at AW048394 RIKEN cDNA 4932441P04 gene8693 0.56062 1.42 up Mm.5066 Zfp93 162105_r_at AV361700 zinc finger protein 938694 0.56091 1.28 up Mm.218862 Mm.218862 101531_at AI527354 Mus musculus, clone MGC:25455 IMAGE:4241025, mRNA, complete cds8695 0.56092 1.11 down Mm.30077 Mm.30077 96881_at AW049394 ESTs, Weakly similar to caldesmon 1, isoform 1; L-CAD; H-CAD; NAG22 pr8696 0.56096 1.08 up Mm.28881 Csnk2a2 94482_at AF012251 casein kinase II, alpha 2, polypeptide8697 0.56096 1.31 down Mm.27182 1110031I02Rik 161915_f_at AV133209 RIKEN cDNA 1110031I02 gene8698 0.56097 1.15 up Mm.22651 Ube2v1 160164_at AW125189 ubiquitin-conjugating enzyme E2 variant 18699 0.56106 1.62 up Mm.3504 Krtap6-3 100735_at D89901 keratin associated protein 6-38700 0.56121 1.12 down Mm.2847 Siah2 97906_at Z19581 seven in absentia 28701 0.56131 1.21 down Mm.3347 Mm.3347 104694_at AI152353 Mus musculus, clone MGC:29357 IMAGE:5038660, mRNA, complete cds8702 0.56153 1.14 up Mm.26166 Acp1 96052_at AI852457 acid phosphatase 1, soluble8703 0.56153 1.28 down Mm.12888 Cacng2 94182_at AF077739 calcium channel, voltage-dependent, gamma subunit 28704 0.56185 1.23 down Mm.104747 Igk-V28 101347_at Z95478 immunoglobulin kappa chain variable 28 (V28)8705 0.56223 1.29 up Mm.140965 Bmpr1a 92767_at D16250 bone morphogenetic protein receptor, type 1A8706 0.56227 1.38 up Mm.5031 Gba 162295_at AV379601 acid beta glucosidase8707 0.56245 1.40 up Mm.1135 Cpa3 102351_at J05118 carboxypeptidase A3, mast cell8708 0.56259 1.48 up Mm.27725 A2m 97216_at M93264 alpha-2-macroglobulin8709 0.56259 1.21 up Mm.154309 Rev1l 98141_at AA647048 REV1-like (S. cerevisiae)8710 0.56273 1.57 up Mm.25788 4633402D15Rik 161485_r_at AV078147 RIKEN cDNA 4633402D15 gene8711 0.56278 1.29 up Mm.28160 5730552M22Rik 95980_at AI851147 RIKEN cDNA 5730552M22 gene8712 0.56282 1.13 down Mm.33575 Gna-rs1 98403_at X65026 guanine nucleotide binding protein, related sequence 18713 0.56283 1.16 up Mm.4503 Np220 99999_at D83033 nuclear protein 2208714 0.56317 1.57 down Mm.29683 1110002H15Rik 162323_at AV081681 RIKEN cDNA 1110002H15 gene8715 0.56326 1.18 up Mm.103655 Mrpl39 93062_at AW045881 mitochondrial ribosomal protein L398716 0.56361 1.27 up Mm.4001 Tshb 97741_at M22740 thyroid stimulating hormone, beta subunit8717 0.56376 1.13 up Mm.142343 2310021M12Rik 99142_at AI834895 RIKEN cDNA 2310021M12 gene8718 0.56376 1.44 up Mm.46422 Nek1 161123_i_at AV086728 NIMA (never in mitosis gene a)-related expressed kinase 18719 0.56376 1.15 down Mm.24086 3930401E15Rik 160183_f_at AI846109 RIKEN cDNA 3930401E15 gene8720 0.56378 1.37 down Mm.7977 Oprk1 99886_at L11065 opioid receptor, kappa 18721 0.56391 1.14 down Mm.40068 Tubb3 160462_f_at AW050256 tubulin, beta 38722 0.56401 1.18 down Mm.6645 Akt1 100970_at X65687 thymoma viral proto-oncogene 18723 0.56402 1.20 up Mm.219541 Mm.219541 102091_f_at AA407599 Mus musculus, Similar to RIKEN cDNA 9030624G23 gene, clone MGC:36378724 0.56410 1.22 down Mm.14926 Atp7a 160609_at AI314990 ATPase, Cu++ transporting, alpha polypeptide8725 0.56419 1.20 up Mm.29395 Gnmt 96828_at D89664 glycine N-methyltransferase8726 0.56438 1.64 down Mm.25003 Fgf10 95976_at D89080 fibroblast growth factor 108727 0.56460 1.20 up Mm.26852 Mm.26852 94937_at AW121594 ESTs, Moderately similar to zinc finger protein 277 [Homo sapiens] [H.sapie8728 0.56462 1.30 down Mm.219464 Cdk2 94411_at AJ223732 cyclin-dependent kinase 28729 0.56469 1.56 up Mm.34606 2610511F02Rik 98090_at AW210014 RIKEN cDNA 2610511F02 gene8730 0.56479 1.33 up Mm.35878 6330509M23Rik 161114_i_at AV330064 RIKEN cDNA 6330509M23 genePage 97 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description8731 0.56516 1.43 up Mm.20899 Lrp4 103289_at AB013874 low density lipoprotein receptor-related protein 48732 0.56517 1.18 up Mm.20396 Crat 103646_at X85983 carnitine acetyltransferase8733 0.56521 1.23 down Mm.10510 Fcna 102065_at AB007813 ficolin A8734 0.56523 1.18 up Mm.4618 Sp1 100032_at X60136 trans-acting transcription factor 18735 0.56535 1.21 up Mm.27664 Ulk2 95537_at AB019577 Unc-51 like kinase 2 (C. elegans)8736 0.56549 1.37 up Mm.29105 Gtf3a 94557_at AI850893 general transcription factor III A8737 0.56566 1.05 down Mm.27332 1110015G04Rik 96652_at AI849911 RIKEN cDNA 1110015G04 gene8738 0.56568 1.35 up Mm.2840 Gpcr25 96553_at U39827 G-protein coupled receptor 258739 0.56592 1.12 down Mm.27082 AU022349 96610_at AW046442 expressed sequence AU0223498740 0.56594 1.26 up Mm.716 Cpsf2 104161_at AW047563 cleavage and polyadenylation specific factor 2, 100kD subunit8741 0.56619 1.33 up Mm.8032 P2rxl1 94631_at AB010883 purinergic receptor P2X-like 1, orphan receptor8742 0.56620 1.22 down Mm.35820 Cpo 98505_i_at D16333 coproporphyrinogen oxidase8743 0.56631 1.17 down Mm.2420 Galt 104616_g_at M96265 galactose-1-phosphate uridyl transferase8744 0.56635 1.29 up Mm.2364 Prtn3 104541_at U43525 proteinase 38745 0.56655 1.19 down Mm.27706 Ash2l 97208_at AB020983 ash2 (absent, small, or homeotic)-like (Drosophila)8746 0.56673 1.33 up Mm.25703 D3Ertd330e 160248_at AA986856 DNA segment, Chr 3, ERATO Doi 330, expressed8747 0.56678 1.28 down Mm.11711 Ppp2ca 92638_at Z67745 protein phosphatase 2a, catalytic subunit, alpha isoform8748 0.56693 1.32 down Mm.34465 Cutl1 104240_at X75013 cut-like 1 (Drosophila)8749 0.56709 1.10 down Mm.28981 Mm.28981 94514_s_at AI853439 Mus musculus, archain 1, clone MGC:27546 IMAGE:4480874, mRNA, comp8750 0.56709 1.14 down Mm.25353 2210417O06Rik 96004_at AI851641 RIKEN cDNA 2210417O06 gene8751 0.56722 1.36 down Mm.108854 Mm.108854 162404_i_at AV283478 ESTs8752 0.56727 1.32 up Mm.4937 Napb 92952_f_at X61455 N-ethylmaleimide sensitive fusion protein attachment protein beta8753 0.56730 1.08 down Mm.927 Bub3 101961_at U67327 budding uninhibited by benzimidazoles 3 homolog (S. cerevisiae)8754 0.56737 1.27 up Mm.16650 Zfp62 103063_at Z67747 zinc finger protein 628755 0.56739 1.22 down Mm.219668 2610209F03Rik 101523_at AW046194 RIKEN cDNA 2610209F03 gene8756 0.56748 1.21 down Mm.7780 Rnf34 101481_at AI852555 ring finger protein 348757 0.56761 1.23 up Mm.57057 Grid2 101734_at D13266 glutamate receptor, ionotropic, delta 28758 0.56769 1.74 down Mm.14438 AU044919 92741_g_at J00475 expressed sequence AU0449198759 0.56792 1.22 down Mm.9404 Nbl1 101969_at D50263 neuroblastoma, suppression of tumorigenicity 18760 0.56807 1.41 up Mm.22720 Ces1 103519_at Y12887 carboxylesterase 18761 0.56821 1.20 up Mm.4349 Cel 99939_at U37386 carboxyl ester lipase8762 0.56825 1.13 up Mm.61526 Pbx1 94804_at L27453 pre B-cell leukemia transcription factor 18763 0.56833 1.21 up Mm.44244 ORF12 99191_at AI844939 open reading frame 128764 0.56840 1.11 up Mm.202715 AI551766 104235_at AW122882 expressed sequence AI5517668765 0.56844 1.31 up Mm.108242 Dnahc8 161398_at AV274650 dynein, axon, heavy chain 88766 0.56844 1.23 up Mm.30405 Zfp94 101655_at U46187 zinc finger protein 948767 0.56858 1.27 down Mm.16757 Slc20a1 103065_at M73696 solute carrier family 20, member 18768 0.56878 1.35 down Mm.703 S100a3 101052_g_at AF004941 S100 calcium binding protein A38769 0.56882 1.13 down Mm.24805 2210415M14Rik 95472_f_at AI526902 RIKEN cDNA 2210415M14 gene8770 0.56903 1.34 down Mm.24695 AA517754 95247_at AA517754 expressed sequence AA5177548771 0.56932 1.10 down Mm.6072 Clta 100579_s_at U91848 clathrin, light polypeptide (Lca)8772 0.56933 1.27 up Mm.24797 Mm.24797 104759_at AI851421 ESTs8773 0.56934 1.25 up Mm.4288 Sry 99556_s_at U03645 sex determining region of Chr Y8774 0.56937 1.39 down Mm.12817 Cappa3 102301_at AB026984 capping protein alpha 38775 0.56958 1.63 up Mm.25048 Mm.25048 95988_r_at C79508 ESTs8776 0.56960 1.47 up Mm.4739 Abcb7 92763_at U43892 ATP-binding cassette, sub-family B (MDR/TAP), member 78777 0.56966 1.11 up Mm.5935 AI317193 162275_f_at AV367141 expressed sequence AI3171938778 0.56983 1.34 up Mm.30126 Mir16-pending 96905_at AI853945 membrane interacting protein of RGS168779 0.56996 1.20 down Mm.29736 Coil 97377_at AI843554 coilin8780 0.57000 1.29 up Mm.148800 Saa1 100333_at M13521 serum amyloid A 18781 0.57009 1.13 up Mm.29088 0610013D04Rik 96125_at AF110520 RIKEN cDNA 0610013D04 gene8782 0.57017 1.19 down Mm.39001 1110018N15Rik 160738_at AI836334 RIKEN cDNA 1110018N15 gene8783 0.57024 1.22 down Mm.28963 1810020E01Rik 94508_at AI853772 RIKEN cDNA 1810020E01 gene8784 0.57047 1.15 up Mm.29971 Snx2 96333_g_at AW259199 sorting nexin 28785 0.57057 1.12 down Mm.21474 Ogfr 160668_at AI838195 opioid growth factor receptor8786 0.57071 1.26 up Mm.4364 Il6st 98349_at X62646 interleukin 6 signal transducer8787 0.57077 1.16 up Mm.22270 C76990 103494_at AI047972 expressed sequence C769908788 0.57099 1.18 down Mm.3552 Clock 92257_at AF000998 circadian locomoter output cycles kaput8789 0.57108 1.27 down Mm.661 Tnp1 161216_at AV266077 transition protein 18790 0.57127 1.33 up Mm.4772 Edg2 100435_at U13370 endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor,8791 0.57139 1.24 up Mm.88795 H2-Q10 101898_s_at X16426 histocompatibility 2, Q region locus 108792 0.57170 1.35 up Mm.23897 Mm.23897 103685_at AI839232 ESTs8793 0.57171 1.18 up Mm.423 Mm.423 99574_at AI850887 ESTs, Weakly similar to AF171875 1 g1-related zinc finger protein [M.muscu8794 0.57176 1.20 up Mm.28108 2310016A09Rik 96122_at AW049373 RIKEN cDNA 2310016A09 gene8795 0.57183 1.28 up Mm.35134 Atp2a1 162223_f_at AV241808 ATPase, Ca++ transporting, cardiac muscle, fast twitch 18796 0.57185 1.21 up Mm.10097 Akap7 96413_at AF047716 A kinase anchor protein 78797 0.57187 1.16 up Mm.5231 9130020K17Rik 93148_at AI851013 RIKEN cDNA 9130020K17 gene8798 0.57213 1.24 up Mm.173 Hoxa5 103086_at Y00208 homeo box A58799 0.57220 1.21 up Mm.4116 Tcte3 99134_at U21673 t-complex-associated <strong>test</strong>is expressed 38800 0.57249 1.30 up Mm.180409 Ube2h 100529_at U19854 ubiquitin-conjugating enzyme E2H8801 0.57273 1.13 down Mm.28026 Mm.28026 97292_at AI845225 Mus musculus, clone IMAGE:3979323, mRNA8802 0.57288 1.35 down Mm.3974 Usp4 161305_r_at AV350431 ubiquitin specific protease 4 (proto-oncogene)8803 0.57294 1.22 up Mm.400 2010000G05Rik 99114_r_at AW045905 RIKEN cDNA 2010000G05 gene8804 0.57295 1.37 down Mm.1286 Svp2 161822_at AV378993 seminal vesicle protein 28805 0.57306 1.14 down Mm.28131 BC005682 160769_at AW120606 hypothetical protein, MGC: 116138806 0.57307 1.50 down Mm.18630 Acadvl 161623_at AV027427 acyl-Coenzyme A dehydrogenase, very long chain8807 0.57321 1.26 down Mm.57252 Ror1 102586_at AB010383 receptor tyrosine kinase-like orphan receptor 18808 0.57330 1.10 down Mm.25634 AI451382 96018_r_at AI853561 expressed sequence AI4513828809 0.57339 1.20 down Mm.4063 Ndr1 160464_s_at U60593 N-myc downstream regulated 18810 0.57339 1.19 up Mm.20190 Pla2g1b 160120_i_at AI327450 phospholipase A2, group IB, pancreas8811 0.57341 1.14 down Mm.25011 Mm.25011 160983_at AA790762 ESTs8812 0.57355 1.32 up Mm.6765 Siah1a 102162_at Z19582 seven in absentia 1A8813 0.57368 1.12 up Mm.14722 Ywhaq 97060_at AW215489 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,8814 0.57368 1.45 up Mm.24001 Mef2c 104590_at L13171 myocyte enhancer factor 2C8815 0.57401 1.26 down Mm.6974 Krt1-14 101041_at M13806 keratin complex 1, acidic, gene 148816 0.57415 1.32 down Mm.56941 Olfr15 98321_at AL078630 olfactory receptor 158817 0.57415 1.10 down Mm.22704 Gnai3 94814_at AI957190 guanine nucleotide binding protein, alpha inhibiting 38818 0.57427 1.15 down Mm.14774 Tead4 102866_at X94441 TEA domain family member 48819 0.57442 1.11 up Mm.17873 Mm.17873 103321_at AI536457 ESTs8820 0.57467 1.33 up Mm.87790 Mageb3 95783_g_at U19033 melanoma antigen, family B, 3Page 98 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description8821 0.57480 1.21 down Mm.100331 AI303072 161022_at AV322780 expressed sequence AI3030728822 0.57485 1.08 down Mm.22440 AL033346 94261_at AI836625 expressed sequence AL0333468823 0.57490 1.21 up Mm.7043 Ii 162171_f_at AV363696 Ia-associated invariant chain8824 0.57503 1.20 down Mm.27403 0610012A19Rik 160231_at AI851129 RIKEN cDNA 0610012A19 gene8825 0.57511 1.44 up Mm.447 AI447904 103615_at AA727023 expressed sequence AI4479048826 0.57514 1.26 down Mm.16898 Phgdh 93127_at L21027 3-phosphoglycerate dehydrogenase8827 0.57532 1.15 up Mm.25248 AA960558 94359_at AI849556 expressed sequence AA9605588828 0.57546 1.23 up Mm.21214 1500001L15Rik 93776_at AW124941 RIKEN cDNA 1500001L15 gene8829 0.57568 1.39 down Mm.182255 Cd97 160276_at Y18365 CD97 antigen8830 0.57572 1.16 down Mm.89866 Tuba7 93924_f_at M13443 tubulin alpha 78831 0.57622 1.22 down Mm.4825 Mmp7 92917_at L36244 matrix metalloproteinase 78832 0.57624 1.43 up Mm.104747 Igk-V28 101656_f_at U60442 immunoglobulin kappa chain variable 28 (V28)8833 0.57628 1.35 up Mm.212716 Mm.212716 100376_f_at AF025445 Mus musculus mRNA for immunoglobulin heavy chain, mAb 6678834 0.57647 1.35 up Mm.4952 Irs1 98824_at X69722 insulin receptor substrate 18835 0.57661 1.19 up Mm.29145 D15Ertd806e 96794_at AI851584 DNA segment, Chr 15, ERATO Doi 806, expressed8836 0.57661 1.18 up Mm.24616 0610039J04Rik 103760_at AI849743 RIKEN cDNA 0610039J04 gene8837 0.57672 1.33 up Mm.29802 Mm.29802 96241_at AI845596 Mus musculus, Similar to CGI-67 protein, clone MGC:11699 IMAGE:3964098838 0.57675 1.23 up Mm.42767 Rps17 102129_at C79471 ribosomal protein S178839 0.57682 1.39 up Mm.27173 Ugcgl 96623_at AI853172 UDP-glucose ceramide glucosyltransferase-like8840 0.57687 1.12 up Mm.2073 AW109744 103257_at AA690483 expressed sequence AW1097448841 0.57688 1.18 down Mm.29483 1600025H15Rik 97320_at AI842734 RIKEN cDNA 1600025H15 gene8842 0.57710 1.13 down Mm.2677 AI851343 160994_at AI851343 expressed sequence AI8513438843 0.57723 1.25 up Mm.39364 Kcnab3 102577_at U65593 potassium voltage-gated channel, shaker-related subfamily, beta member 38844 0.57736 1.32 up Mm.42040 Ak4 99959_at AW061337 adenylate kinase 48845 0.57742 1.11 up Mm.24655 1110059E24Rik 160717_at AI854226 RIKEN cDNA 1110059E24 gene8846 0.57781 1.21 up Mm.5118 Ppnr-pending 101186_at X65588 per-pentamer repeat gene8847 0.57782 1.34 down Mm.10669 Gdc1 161753_f_at AV290060 glycerol phosphate dehydrogenase 1, cytoplasmic adult8848 0.57805 1.12 down Mm.29698 Uble1a 95703_at AB024303 ubiquitin-like 1 (sentrin) activating enzyme E1A8849 0.57806 1.22 up Mm.27903 6330407G11Rik 162260_at AV341723 RIKEN cDNA 6330407G11 gene8850 0.57809 1.50 up Mm.57174 Pstpip2 99433_at Y18101 proline-serine-threonine phosphatase-interacting protein 28851 0.57815 1.18 down Mm.379 E2f5 98995_at X86925 E2F transcription factor 58852 0.57816 1.35 up Mm.4906 Zfp90 92934_at X79828 zinc finger protein 908853 0.57822 1.29 up Mm.21070 AI504353 161421_r_at AV292380 expressed sequence AI5043538854 0.57851 1.33 down Mm.141324 Prp13-pending 101417_at AF020191 proline-rich protein 138855 0.57852 1.20 up Mm.6190 Avp 93381_at M88354 arginine vasopressin8856 0.57857 1.14 up Mm.28293 2900053E13Rik 160284_at AI844890 RIKEN cDNA 2900053E13 gene8857 0.57868 1.21 down Mm.18472 2300001E01Rik 93310_at AI836423 RIKEN cDNA 2300001E01 gene8858 0.57871 1.21 up Mm.227 1110004F14Rik 104386_f_at AI843901 RIKEN cDNA 1110004F14 gene8859 0.57884 1.20 down Mm.12051 St7 160591_at AI504013 suppression of tumorigenicity 78860 0.57886 1.45 up Mm.9213 Esr1 93945_at M38651 estrogen receptor 1 (alpha)8861 0.57892 1.53 down Mm.20314 1700001F22Rik 103632_at AI036958 RIKEN cDNA 1700001F22 gene8862 0.57901 1.13 up Mm.214030 Mm.214030 100289_at U92885 ESTs, Highly similar to EFA3 MOUSE EPHRIN-A3 [M.musculus]8863 0.57902 1.27 up Mm.57033 Mm.57033 97568_at AF045027 M.musculus immunoglobulin kappa chain variable region8864 0.57902 1.34 up Mm.57040 Slc6a2 99408_at U76306 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 28865 0.57917 1.50 up Mm.529 Ifng 99334_at K00083 interferon gamma8866 0.57928 1.16 down Mm.1706 AA409185 161386_f_at AV252908 expressed sequence AA4091858867 0.57929 1.40 down Mm.3596 Cops2 98539_at AF071312 COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thal8868 0.57934 1.25 down Mm.548 Cox6c 162319_i_at AV071102 cytochrome c oxidase, subunit VIc8869 0.57952 1.36 up Mm.22554 BC003945 161701_at AV236130 hypothetical protein BC0039458870 0.57955 1.07 up Mm.16533 Rpo2-1 103054_at U37500 RNA polymerase II 18871 0.57956 1.32 up Mm.158200 Aldrl6 93781_at AI119007 aldehyde reductase (aldose reductase)-like 68872 0.57964 1.13 down Mm.24216 Rbbp9 104618_at AI845819 retinoblastoma binding protein 98873 0.57989 1.18 down Mm.182122 Dedd 160160_at AF100342 death effector domain-containing8874 0.58000 1.30 down Mm.46801 Mm.46801 102153_at M36690 M.musculus mRNA (2F7) for IgA V-D-J-heavy chain8875 0.58020 1.37 up Mm.3919 2810011G06Rik 162354_f_at AV160069 RIKEN cDNA 2810011G06 gene8876 0.58029 1.16 down Mm.676 Atf1 100984_at M63725 activating transcription factor 18877 0.58045 1.17 down Mm.1232 Mm.1232 92778_i_at Z22552 Mus musculus, clone MGC:8060 IMAGE:3587523, mRNA, complete cds8878 0.58045 1.77 down Mm.13300 C79490 94690_at C79514 expressed sequence C794908879 0.58047 1.11 down Mm.2236 Pura 103501_at U02098 purine rich element binding protein A8880 0.58058 1.17 down Mm.181074 2610001E17Rik 160298_at AW122012 RIKEN cDNA 2610001E17 gene8881 0.58064 1.23 up Mm.38469 Apbb1 99014_at AI839886 amyloid beta (A4) precursor protein-binding, family B, member 18882 0.58065 1.10 down Mm.21978 Mm.21978 104120_at AW049205 ESTs, Moderately similar to T14771 hypothetical protein DKFZp566F084.1 [8883 0.58071 1.19 down Mm.1881 AI325941 161627_r_at AV174870 expressed sequence AI3259418884 0.58084 1.31 up Mm.3909 Smarca3 92343_at AF010138 SWI/SNF related, matrix associated, actin dependent regulator of chromatin,8885 0.58086 1.41 up Mm.57150 Magea4 101807_at AJ005528 melanoma antigen, family A, 48886 0.58096 1.35 up Mm.22845 Src 99388_at M17031 Rous sarcoma oncogene8887 0.58106 1.19 down Mm.30991 Phkg2 161217_r_at AV249638 5phosphorylase kinase, gamma 2 (<strong>test</strong>is)8888 0.58109 1.24 up Mm.1384 Trim21 102678_at L27990 tripartite motif protein 218889 0.58115 1.20 down Mm.182383 1810014G04Rik 97397_at AI848344 RIKEN cDNA 1810014G04 gene8890 0.58139 1.28 down Mm.1480 Ephb6 162371_r_at AV240015 Eph receptor B68891 0.58142 1.15 down Mm.1203 Fut7 94138_s_at U45980 fucosyltransferase 78892 0.58156 1.21 down Mm.7342 Pdlim3 101089_at AF002283 PDZ and LIM domain 38893 0.58158 1.18 down Mm.14501 Ppm1g 92879_at U42383 protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isofo8894 0.58164 1.23 up Mm.29466 Klf7 104645_at AI853712 Kruppel-like factor 7 (ubiquitous)8895 0.58167 1.08 down Mm.2756 Hmgn1 96699_at X53476 high mobility group nucleosomal binding domain 18896 0.58169 1.14 down Mm.21246 1500019O16Rik 103885_at AW049156 RIKEN cDNA 1500019O16 gene8897 0.58171 1.15 up Mm.347 1810007M14Rik 92233_at AI098965 RIKEN cDNA 1810007M14 gene8898 0.58171 1.22 down Mm.11660 D12Ertd604e 160587_at AW050018 DNA segment, Chr 12, ERATO Doi 604, expressed8899 0.58174 1.44 up Mm.24245 Tcea2 104622_at D86081 transcription elongation factor A (SII), 28900 0.58198 1.23 down Mm.4113 Rae1 160466_at AI048716 RAE1 RNA export 1 homolog (S. pombe)8901 0.58215 1.33 up Mm.29014 Tiam2 160796_at AB022915 T-cell lymphoma invasion and metastasis 28902 0.58229 1.54 down Mm.5763 D12Ertd216e 101597_at C78885 DNA segment, Chr 12, ERATO Doi 216, expressed8903 0.58230 1.37 down Mm.41816 Fap 92441_at Y10007 fibroblast activation protein8904 0.58231 1.53 down Mm.103038 Axcam 102560_at X99043 axonal-associated cell adhesion molecule8905 0.58233 1.14 down Mm.7330 Mm.7330 101409_at AI429868 Mus musculus, Similar to ligatin, clone IMAGE:4982955, mRNA, partial cds8906 0.58237 1.55 up Mm.153466 Scn6a 101132_at L36179 sodium channel, voltage-gated, type VI, alpha polypeptide8907 0.58249 1.37 down Mm.5083 Rab3a 161790_at AV347669 RAB3A, member RAS oncogene family8908 0.58270 1.31 up Mm.5306 Mm.5306 101216_at R75193 EST8909 0.58299 1.16 up Mm.6488 1110014E10Rik 93426_at AA199023 RIKEN cDNA 1110014E10 gene8910 0.58300 1.59 up Mm.5706 Mm.5706 99416_at AU042276 ESTs, Moderately similar to S12207 hypothetical protein [M.musculus]Page 99 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description8911 0.58304 1.37 up Mm.214981 Hist1 101783_i_at X16496 histone gene complex 18912 0.58307 1.40 up Mm.26166 Acp1 161659_f_at AV115928 acid phosphatase 1, soluble8913 0.58311 1.16 up Mm.1843 Hsp86-1 95282_at J04633 heat shock protein, 86 kDa 18914 0.58311 1.27 up Mm.31472 Mesp2 97092_at U71125 mesoderm posterior 28915 0.58332 1.17 up Mm.7420 Tubb4 101419_at M28730 tubulin, beta 48916 0.58337 1.25 up Mm.40678 Pde1a 160861_s_at AI385600 phosphodiesterase 1A, calmodulin-dependent8917 0.58401 1.14 up Mm.4220 Ptprs 160480_at X82288 protein tyrosine phosphatase, receptor type, S8918 0.58401 1.14 down Mm.36241 Bcap37 98545_at X78683 B-cell receptor-associated protein 378919 0.58409 1.19 down Mm.28107 Enpp2 97317_at AW122933 ectonucleotide pyrophosphatase/phosphodiesterase 28920 0.58428 1.64 down Mm.30243 Mm.30243 162140_i_at AV348223 Mus musculus mRNA for HELG, complete cds8921 0.58451 1.19 up Mm.153729 2210010C04Rik 100103_f_at AE000663 RIKEN cDNA 2210010C04 gene8922 0.58463 1.17 down Mm.27635 1110014N07Rik 96711_at AI849191 RIKEN cDNA 1110014N07 gene8923 0.58486 1.21 down Mm.86538 Ccnt1 93712_at AF095640 cyclin T18924 0.58494 1.26 up Mm.30115 2310061P20Rik 97437_f_at AW122483 RIKEN cDNA 2310061P20 gene8925 0.58506 1.16 down Mm.25640 2700026H11Rik 103965_at AI837032 RIKEN cDNA 2700026H11 gene8926 0.58521 1.43 up Mm.153710 B3galt3 98960_s_at AF029792 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 38927 0.58547 1.07 down Mm.29925 Il25 96318_at AW045739 interleukin 258928 0.58551 1.46 up Mm.3140 Mpdz 161708_f_at AV244715 multiple PDZ domain protein8929 0.58563 1.18 down Mm.18761 2010003B14Rik 103402_at AI848522 RIKEN cDNA 2010003B14 gene8930 0.58578 1.36 down Mm.139314 Esg1 160370_at AA683849 embryonal stem cell specific gene 18931 0.58585 1.15 down Mm.200540 R74921 102071_at AI851565 expressed sequence R749218932 0.58594 1.15 up Mm.29711 Adrbk1 104270_at AA982714 adrenergic receptor kinase, beta 18933 0.58596 1.18 up Mm.4258 Ogn 99549_at D31951 osteoglycin8934 0.58609 1.31 up Mm.183102 Actr3 97904_at AW123953 actin-related protein 3 homolog (yeast)8935 0.58620 1.32 up Mm.153893 Psg-ps1 97087_f_at M83348 pregnancy specific glycoprotein pseudogene 18936 0.58638 1.14 up Mm.29415 1810011O01Rik 95131_f_at AI852592 RIKEN cDNA 1810011O01 gene8937 0.58647 1.10 up Mm.24498 Arpc3 95434_at AI851740 actin related protein 2/3 complex, subunit 3 (21 kDa)8938 0.58664 1.39 up Mm.22789 Mm.22789 95370_at AI413435 ESTs, Highly similar to CAD4 MOUSE RETINAL-CADHERIN PRECURSOR8939 0.58667 1.19 up Mm.4150 Osp94 99489_at U23921 osmotic stress protein 94 kDa8940 0.58671 1.25 up Mm.39094 Nog 97727_at U79163 noggin8941 0.58674 1.13 down Mm.41665 1110025J15Rik 99161_at AI843359 RIKEN cDNA 1110025J15 gene8942 0.58689 1.18 down Mm.28370 AU021979 96165_at AW125109 expressed sequence AU0219798943 0.58693 1.35 up Mm.11223 Xdh 97950_at X75129 xanthine dehydrogenase8944 0.58726 1.18 down Mm.219656 Mm.219656 93325_at AI845735 Mus musculus, Similar to polymerase (RNA) II (DNA directed) polypeptide E8945 0.58742 1.10 down Mm.24731 0610012C09Rik 160193_at AW125340 RIKEN cDNA 0610012C09 gene8946 0.58755 1.29 up Mm.2620 Slc19a1 94419_at L23755 solute carrier family 19 (sodium/hydrogen exchanger), member 18947 0.58757 1.52 up Mm.4608 Pvt1 92707_at Z11981 plasmacytoma variant translocation 18948 0.58770 1.21 down Mm.27927 Hnrpa1 97272_at M99167 heterogeneous nuclear ribonucleoprotein A18949 0.58772 1.26 up Mm.28958 Mm.28958 96749_f_at AA619554 ESTs, Weakly similar to T47140 hypothetical protein DKFZp761K1115.1 [H.s8950 0.58781 1.16 up Mm.123038 AA409318 160208_at AW122772 expressed sequence AA4093188951 0.58791 1.22 up Mm.22080 Gdap2 104134_at Y17851 ganglioside-induced differentiation-associated-protein 28952 0.58792 1.42 down Mm.13170 Mm.13170 94684_at AA516942 ESTs8953 0.58798 1.13 down Mm.22711 Ccni 94820_r_at AF005886 cyclin I8954 0.58811 1.24 up Mm.1268 Plp 102101_f_at AI850387 proteolipid protein (myelin)8955 0.58819 1.32 down Mm.140810 Mm.140810 94691_at C80498 ESTs, Weakly similar to YO11 MOUSE HYPOTHETICAL PROTEIN ORF-118956 0.58819 1.44 up Mm.182442 Keg1 96938_at AB028071 kidney expressed gene 18957 0.58833 1.06 down Mm.30624 Eg1-pending 95044_at AI844549 endothelial-derived gene8958 0.58849 1.22 up Mm.25000 C78788 95876_at C78788 expressed sequence C787888959 0.58869 1.28 up Mm.2477 Prph1 161482_f_at AV068234 peripherin 18960 0.58876 1.24 up Mm.157460 Krt2-10 93556_at X99143 keratin complex 2, basic, gene 108961 0.58886 1.17 down Mm.25715 AW226533 103969_at AA981154 expressed sequence AW2265338962 0.58893 1.29 up Mm.608 2700089E24Rik 100925_at AI131982 RIKEN cDNA 2700089E24 gene8963 0.58909 1.22 up Mm.2325 3230402E02Rik 104534_at AA623874 RIKEN cDNA 3230402E02 gene8964 0.58922 1.14 up Mm.826 Pigf 101466_at D50264 phosphatidylinositol glycan, class F8965 0.58923 1.10 down Mm.28327 2510049I19Rik 97866_at AI842858 RIKEN cDNA 2510049I19 gene8966 0.58937 1.26 up Mm.26528 Zfp95 94434_at U62907 zinc finger protein 958967 0.58941 1.11 down Mm.10172 Ctbp2 92554_at AF059735 C-terminal binding protein 28968 0.58964 1.16 down Mm.18513 Tbn-pending 103363_at AW214244 taube nuss8969 0.59032 1.33 up Mm.8217 D6H12S2489E 93679_at AF030313 DNA Segment, Chr 6, human D12S2489E8970 0.59046 1.38 up Mm.142728 Prlpc 99530_at AF090140 prolactin-like protein C8971 0.59054 1.44 down Mm.29032 D10Ertd214e 161504_i_at AV127302 DNA segment, Chr 10, ERATO Doi 214, expressed8972 0.59057 1.28 up Mm.5348 1700010P14Rik 161632_r_at AV046734 RIKEN cDNA 1700010P14 gene8973 0.59061 1.16 down Mm.25779 4930512K19Rik 96029_at AI020542 RIKEN cDNA 4930512K19 gene8974 0.59062 1.15 up Mm.12864 1190002L16Rik 92817_at AW120646 RIKEN cDNA 1190002L16 gene8975 0.59070 1.35 up Mm.196320 5830405F06Rik 93106_i_at M20878 RIKEN cDNA 5830405F06 gene8976 0.59083 1.16 up Mm.12863 Hs2st1 102306_at AF060178 heparan sulfate 2-O-sulfotransferase 18977 0.59085 1.13 up Mm.42026 P2rx7 101712_at AJ009823 purinergic receptor P2X, ligand-gated ion channel, 78978 0.59086 1.46 up Mm.6751 Mm.6751 93450_at AI594295 ESTs, Weakly similar to S28261 centromere protein E [H.sapiens]8979 0.59090 1.09 down Mm.196038 Ppp4c 95631_at AF088911 protein phosphatase 4, catalytic subunit8980 0.59094 1.28 up Mm.987 Map4k4 102195_at U88984 mitogen-activated protein kinase kinase kinase kinase 48981 0.59094 1.28 up Mm.6161 Pcyt1a 99035_at U84207 phosphate cytidylyltransferase 1, choline, alpha isoform8982 0.59098 1.17 down Mm.23962 2610301B20Rik 94893_at AI840411 RIKEN cDNA 2610301B20 gene8983 0.59108 1.21 down Mm.203962 Bat3 93921_at AI573601 HLA-B-associated transcript 38984 0.59109 1.19 up Mm.89484 LOC56795 92370_at AI853831 ADP-ribosylation factor-like membrane-associated protein Arm18985 0.59113 1.17 up Mm.157648 5730403B10Rik 93970_at AI843085 RIKEN cDNA 5730403B10 gene8986 0.59124 1.36 up Mm.24900 Mm.24900 95946_at C76142 ESTs8987 0.59125 1.84 up Mm.143846 Ptprc 101297_at M23158 protein tyrosine phosphatase, receptor type, C8988 0.59145 1.08 down Mm.24517 1110029L11Rik 104720_at AI854789 RIKEN cDNA 1110029L11 gene8989 0.59152 1.12 down Mm.16831 Ckb 93126_at X04591 creatine kinase, brain8990 0.59163 1.11 up Mm.29106 Prss15 160328_at AI838015 protease, serine, 158991 0.59171 1.25 down Mm.3398 Nr2c1 92190_at U28280 nuclear receptor subfamily 2, group C, member 18992 0.59174 1.46 down Mm.10194 Myom2 102041_at AJ001038 myomesin 28993 0.59232 1.42 up Mm.88235 Mm.88235 96408_at C79309 EST8994 0.59241 1.17 up Mm.12904 Stc2 102624_at AF031035 stanniocalcin 28995 0.59261 1.31 up Mm.188571 Mm.188571 95307_at AW047736 ESTs, Weakly similar to T42721 CRP-ductin-alpha precursor - mouse [M.mu8996 0.59265 1.15 up Mm.29708 D4Wsu114e 104466_at AI853033 DNA segment, Chr 4, Wayne State University 114, expressed8997 0.59290 1.10 down Mm.2206 Ndufv2 94062_at AI847609 NADH dehydrogenase (ubiquinone) flavoprotein 28998 0.59298 1.45 up Mm.24887 Npl-pending 94330_at AA710564 N-acetylneuraminate pyruvate lyase8999 0.59302 1.20 down Mm.710 Hmox2 101062_at AF054670 heme oxygenase (decycling) 29000 0.59309 1.21 up Mm.27654 Mm.27654 104207_at AI430272 ESTs, Weakly similar to DIA1 MOUSE DIAPHANOUS PROTEIN HOMOLOGPage 100 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description9001 0.59316 1.18 up Mm.24098 Mm.24098 103710_at AI037032 ESTs, Weakly similar to A48830 probable transcription regulator NT fin12 - m9002 0.59323 1.18 up Mm.23961 3110023F10Rik 104579_r_at AI195392 RIKEN cDNA 3110023F10 gene9003 0.59333 1.19 up Mm.2355 Phb 94855_at X78682 prohibitin9004 0.59333 1.11 up Mm.219 Mm.219 160676_at AI839212 Mus musculus, clone IMAGE:2647796, mRNA9005 0.59345 1.10 down Mm.2000 Mm.2000 93539_at AI118854 ESTs, Highly similar to THROMBOSPONDIN 2 PRECURSOR [M.musculus]9006 0.59347 1.22 down Mm.27546 8430408O15Rik 95035_at AI467390 RIKEN cDNA 8430408O15 gene9007 0.59351 1.17 up Mm.140597 DXImx39e 97341_at AW124082 DNA segment, Chr X, Immunex 39, expressed9008 0.59353 1.21 up Mm.36566 AA575098 97193_at AA575098 expressed sequence AA5750989009 0.59356 1.15 down Mm.1619 C2ta 102917_at AF042158 class II transactivator9010 0.59369 1.07 down Mm.195912 9130026N02Rik 160779_at AI843849 RIKEN cDNA 9130026N02 gene9011 0.59389 1.26 down Mm.57195 Nodal 99801_at X70514 nodal9012 0.59400 1.46 up Mm.140151 Sprr1b 100445_f_at X91825 small proline-rich protein 1B9013 0.59411 1.25 up Mm.716 Cpsf2 160542_at AF012822 cleavage and polyadenylation specific factor 2, 100kD subunit9014 0.59411 1.25 up Mm.6252 Col19a1 99842_at AB000636 procollagen, type XIX, alpha 19015 0.59426 1.16 up Mm.29721 2810025M15Rik 97374_at AI840458 RIKEN cDNA 2810025M15 gene9016 0.59429 1.15 down Mm.180337 3110002K08Rik 97309_at AW214164 RIKEN cDNA 3110002K08 gene9017 0.59468 1.07 down Mm.22635 AA415817 94312_at AI180784 expressed sequence AA4158179018 0.59490 1.09 down Mm.27855 Rfc2 160759_at AA597246 replication factor C (activator 1) 2 (40kD)9019 0.59491 1.12 up Mm.4888 Rad50 100459_at U66887 RAD50 homolog (S. cerevisiae)9020 0.59520 1.15 down Mm.27311 AI463227 94989_at AI848984 expressed sequence AI4632279021 0.59539 1.20 down Mm.6424 Itgb5 100601_at AF022110 integrin beta 59022 0.59565 1.21 up Mm.4390 Numb 99955_at U70674 numb gene homolog (Drosophila)9023 0.59570 1.21 up Mm.7013 0610038L10Rik 97103_at AF031380 RIKEN cDNA 0610038L10 gene9024 0.59577 1.48 up Mm.10709 Ugdh 102322_at AF061017 UDP-glucose dehydrogenase9025 0.59594 1.32 down Mm.7973 Ids 99884_at X75636 iduronate 2-sulfatase9026 0.59599 1.37 down Mm.37 Hox11l1 97679_at M75953 homeo box 11-like 19027 0.59601 1.23 up Mm.30162 Smoc2 96926_at AA980164 secreted modular calcium binding protein 29028 0.59606 1.36 up Mm.27801 Slc30a4 161230_r_at AV275485 solute carrier family 30 (zinc transporter), member 49029 0.59627 1.15 up Mm.31775 Sit-pending 104660_at AJ236881 SHP2 interacting transmembrane adaptor9030 0.59627 1.18 up Mm.10704 Snx12 102320_at AI844369 sorting nexin 129031 0.59652 1.11 down Mm.205601 Mm.205601 94054_at AI841808 Mus musculus, Similar to cortactin isoform B, clone MGC:18474 IMAGE:3989032 0.59654 1.30 up Mm.57205 Adra2c 99804_at M97516 adrenergic receptor, alpha 2c9033 0.59678 1.21 down Mm.196557 D2Wsu81e 100054_s_at AW123127 DNA segment, Chr 2, Wayne State University 81, expressed9034 0.59684 1.26 up Mm.195987 V2r8 101644_f_at AF011418 vomeronasal 2, receptor, 89035 0.59695 1.23 up Mm.388 Ada 93206_g_at M14167 adenosine deaminase9036 0.59716 1.15 up Mm.2834 Glyt1 96160_at X67056 glycine transporter 19037 0.59728 1.10 down Mm.195313 D8Ertd812e 99656_at AI849027 DNA segment, Chr 8, ERATO Doi 812, expressed9038 0.59731 1.12 down Mm.88678 Dnajc2 101890_f_at U53208 DnaJ (Hsp40) homolog, subfamily C, member 29039 0.59739 1.13 up Mm.28780 Plxnb2 160311_at AI841137 plexin B29040 0.59744 1.56 down Mm.8046 Cdkn1b 100278_at U09968 cyclin-dependent kinase inhibitor 1B (P27)9041 0.59744 1.40 up Mm.55398 Mm.55398 161192_at AV252273 ESTs9042 0.59747 1.27 up Mm.14489 Klrb1b 94744_at M77677 killer cell lectin-like receptor subfamily B member 1B9043 0.59770 1.40 up Mm.25259 C81222 160989_r_at AA717225 expressed sequence C812229044 0.59770 1.18 up Mm.3077 Nr1i3 102171_r_at AI132241 nuclear receptor subfamily 1, group I, member 39045 0.59783 1.17 down Mm.12258 1110030J09Rik 160596_at AW050048 RIKEN cDNA 1110030J09 gene9046 0.59784 1.16 down Mm.22072 Noc4 104132_at AW047276 neighbor of Cox49047 0.59786 1.20 up Mm.157743 Ddx6 93965_r_at AF038995 DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 69048 0.59805 1.17 down Mm.4347 Xrcc1 161560_f_at AV264181 X-ray repair complementing defective repair in Chinese hamster cells 19049 0.59805 1.27 up Mm.4846 Lmnb1 160517_at M35153 lamin B19050 0.59856 1.40 up Mm.1940 Csf2rb2 161544_r_at AV242068 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macroph9051 0.59881 1.18 up Mm.180587 5730406O18Rik 162138_s_at AV343519 RIKEN cDNA 5730406O18 gene9052 0.59893 1.20 up Mm.24639 1700012B15Rik 95924_at AA473729 RIKEN cDNA 1700012B15 gene9053 0.59908 1.23 down Mm.21146 Gata6 93925_at AJ243146 GATA binding protein 69054 0.59921 1.10 up Mm.42927 Limk2 99606_at AB005132 LIM motif-containing protein kinase 29055 0.59921 1.13 down Mm.88829 Casp9 100366_at AB019600 caspase 99056 0.59930 1.19 down Mm.3770 Sos2 92302_at Z11664 Son of sevenless homolog 2, (Drosophila)9057 0.59957 1.17 up Mm.7504 Gss 162246_r_at AV333320 glutathione synthetase9058 0.59989 1.06 down Mm.122494 Mm.122494 92963_at AI843231 Mus musculus, similar to CG6734 gene product (H. sapiens), clone MGC:329059 0.59989 1.14 down Mm.29719 Elp3 95717_at AI851229 elongation protein 3 homolog (S. cerevisiae)9060 0.60006 1.41 up Mm.4046 Ms4a2 99446_at M62541 membrane-spanning 4-domains, subfamily A, member 29061 0.60007 1.14 up Mm.41531 2410044K02Rik 99490_at AW050348 RIKEN cDNA 2410044K02 gene9062 0.60024 1.46 up Mm.30246 Cd151 97931_i_at D89290 CD151 antigen9063 0.60037 1.22 up Mm.27490 Mm.27490 161618_r_at AV354397 Mus musculus, Similar to hypothetical protein FLJ20174, clone IMAGE:35959064 0.60057 1.39 up Mm.206404 Mm.206404 162283_r_at AV372356 Mus musculus mRNA for 67 kDa polymerase-associated factor PAF67 (paf69065 0.60063 1.21 up Mm.34940 D3Ertd229e 97141_s_at C79038 DNA segment, Chr 3, ERATO Doi 229, expressed9066 0.60067 1.46 up Mm.5014 Ndph 92976_at X92397 Norrie disease homolog9067 0.60068 1.24 up Mm.144448 Cdx1 103477_at M80463 caudal type homeo box 19068 0.60096 1.32 up Mm.416 Traip 162407_at AV313656 TRAF-interacting protein9069 0.60105 1.31 up Mm.3463 1200014D22Rik 97131_at AW124615 RIKEN cDNA 1200014D22 gene9070 0.60110 1.25 down Mm.2079 Syngr2 93586_at AJ002307 synaptogyrin 29071 0.60115 1.28 up Mm.4172 Slbp 160471_at U75680 stem-loop binding protein9072 0.60140 1.25 down Mm.139091 Mm.139091 94674_at AA408617 EST9073 0.60145 1.16 up Mm.5032 Prph2 161874_r_at AV360626 peripherin 29074 0.60146 1.21 up Mm.46711 Fshb 101737_at U12932 follicle stimulating hormone beta9075 0.60155 1.23 up Mm.29200 2310006I24Rik 95075_at AW229141 RIKEN cDNA 2310006I24 gene9076 0.60166 1.13 down Mm.12909 Apba3 102750_at AF070975 amyloid beta (A4) precursor protein-binding, family A, member 39077 0.60189 1.08 up Mm.88546 Crlz1 103876_at AA760339 charged amino acid rich leucine zipper 19078 0.60221 1.18 up Mm.196037 Hoxb8 96418_r_at M18399 homeo box B89079 0.60235 1.12 up Mm.213000 Mm.213000 99997_at Y07611 ESTs, Highly similar to PC4220 protein kinase [M.musculus]9080 0.60243 1.30 down Mm.18300 Slc3a1 93304_at D88533 solute carrier family 3, member 19081 0.60244 1.36 up Mm.46114 Mm.46114 160505_at AA499784 ESTs9082 0.60271 1.29 up Mm.4980 Chrne 92965_at J04698 cholinergic receptor, nicotinic, epsilon polypeptide9083 0.60276 1.14 up Mm.46801 Mm.46801 99421_at X82692 M.musculus mRNA (2F7) for IgA V-D-J-heavy chain9084 0.60278 1.46 down Mm.104747 Igk-V28 101330_f_at U55617 immunoglobulin kappa chain variable 28 (V28)9085 0.60279 1.35 up Mm.2565 Fig1 96515_at U70430 interleukin-four induced gene 19086 0.60287 1.21 up 93208_at AE0006659087 0.60291 1.14 up Mm.19187 Ptma 100718_at X56135 prothymosin alpha9088 0.60325 1.39 up Mm.9199 Pole2 101920_at AF036898 DNA polymerase epsilon, subunit 29089 0.60326 1.21 up Mm.200358 Tcf7 97995_at X61385 transcription factor 7, T-cell specific9090 0.60327 1.20 down Mm.59353 Prm3 160528_at Z47352 protamine 3Page 101 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description9091 0.60336 1.54 up Mm.141307 Mm.141307 162306_at AV046521 ESTs9092 0.60357 1.65 up Mm.14101 H1f4 94718_at L04141 H1 histone family, member 49093 0.60361 1.34 up Mm.4599 Astn1 92702_at U48797 astrotactin 19094 0.60399 1.32 up Mm.214981 Hist1 94756_at M32461 histone gene complex 19095 0.60401 1.12 up Mm.42108 Dpysl2 98298_at Y10339 dihydropyrimidinase-like 29096 0.60408 1.18 up Mm.138199 4631401O15Rik 94060_at AI852623 RIKEN cDNA 4631401O15 gene9097 0.60433 1.10 down Mm.1387 Rab11a 92854_at D50500 RAB11a, member RAS oncogene family9098 0.60442 1.37 up Mm.5058 Cadps 92988_i_at D86214 Cadependent activator protein for secretion9099 0.60475 1.37 up Mm.20954 Rgs5 96180_at AA958696 regulator of G-protein signaling 59100 0.60480 1.10 up Mm.133962 Vdac3 160551_at U30839 voltage-dependent anion channel 39101 0.60481 1.35 up Mm.8924 Cdkn2b 101900_at AF059567 cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)9102 0.60493 1.15 down Mm.26513 AI255964 96074_at AI528149 expressed sequence AI2559649103 0.60508 1.40 down Mm.4970 Kcnj12 98829_at X80417 potassium inwardly-rectifying channel, subfamily J, member 129104 0.60509 1.72 up Mm.9500 Zpbp 93955_at D17569 zona pellucida binding protein9105 0.60514 1.14 up Mm.26484 2410003H12Rik 94430_at AI850991 RIKEN cDNA 2410003H12 gene9106 0.60515 1.27 up Mm.3808 AA414903 100750_at AA414903 expressed sequence AA4149039107 0.60517 1.23 up Mm.27975 AA672641 96544_at AA672641 expressed sequence AA6726419108 0.60538 1.30 up Mm.3124 3110015B12Rik 97496_f_at AW048944 RIKEN cDNA 3110015B12 gene9109 0.60558 1.32 up Mm.5829 Mm.5829 161126_at AV357533 ESTs, Moderately similar to T47153 hypothetical protein DKFZp564A0772.19110 0.60559 1.42 down Mm.177 AI505014 94793_at AA796791 expressed sequence AI5050149111 0.60567 1.11 down Mm.10214 Tuft1 102043_at AF047704 tuftelin 19112 0.60601 1.17 up Mm.2857 Admr 104271_at D17292 adrenomedullin receptor9113 0.60607 1.24 up Mm.4679 Gdnf 92738_at D49921 glial cell line derived neurotrophic factor9114 0.60611 1.20 down Mm.9524 Cited2 101973_at Y15163 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal doma9115 0.60617 1.21 down Mm.89962 Pfp 93932_at J04148 pore forming protein9116 0.60626 1.31 up Mm.2168 Hc 103458_at M35525 hemolytic complement9117 0.60627 1.14 up Mm.180776 2610318G18Rik 96688_at AI845463 RIKEN cDNA 2610318G18 gene9118 0.60646 1.21 down Mm.28921 Cldn3 94493_at AF095905 claudin 39119 0.60692 1.16 down Mm.14189 AI841487 102702_at AI841487 expressed sequence AI8414879120 0.60713 1.58 up Mm.3962 Blk 92359_at M30903 B lymphoid kinase9121 0.60718 1.08 down Mm.29703 D7Wsu86e 95709_at AW012491 DNA segment, Chr 7, Wayne State University 86, expressed9122 0.60744 1.18 down Mm.35867 Ccne2 104142_at AI626975 cyclin E29123 0.60744 1.10 up Mm.193040 Mrps7 96904_at AI848784 mitchondrial ribosomal protein S79124 0.60763 1.26 up Mm.1355 Iga 102778_at X13450 immunoglobulin-associated alpha9125 0.60769 1.20 up Mm.145488 AU018965 162093_at AV320437 expressed sequence AU0189659126 0.60787 1.21 down Mm.28413 2410004C24Rik 97891_at AI849500 RIKEN cDNA 2410004C24 gene9127 0.60800 1.07 down Mm.8884 Nfkbia 104149_at AI642048 nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha9128 0.60837 1.33 up Mm.56933 Fut1 99381_at Y09883 fucosyltransferase 19129 0.60845 1.37 up Mm.8030 Znfn1a2 94630_at AF044257 zinc finger protein, subfamily 1A, 2 (Helios)9130 0.60850 1.09 down Mm.20948 Tcn2 93736_at AF090686 transcobalamin 29131 0.60860 1.18 up Mm.12901 Hcn3 94188_at AJ225124 hyperpolarization-activated, cyclic nucleotide-gated K+ 39132 0.60863 1.35 up Mm.3489 Saa4 92242_at U65403 serum amyloid A 49133 0.60879 1.13 down Mm.28196 Snx4 97818_at AI838691 sorting nexin 49134 0.60888 1.35 down Mm.5076 Tll 98850_at U34042 tolloid-like9135 0.60889 1.11 up Mm.142814 Arpc4 160094_at AW123518 actin related protein 2/3 complex, subunit 4 (20 kDa)9136 0.60890 1.31 down Mm.14526 Mylpf 162101_f_at AV290649 myosin light chain, phosphorylatable, fast skeletal muscle9137 0.60897 1.14 down Mm.88572 1810020G14Rik 160556_at AW048976 RIKEN cDNA 1810020G14 gene9138 0.60903 1.09 up Mm.24463 2610044B22Rik 95432_f_at AI844034 RIKEN cDNA 2610044B22 gene9139 0.60907 1.25 down Mm.44194 Clic3 160884_at AI415208 chloride intracellular channel 39140 0.60929 1.18 down Mm.27026 Clgn 161734_r_at AV280513 calmegin9141 0.60939 1.18 down Mm.1011 Ncoa3 102024_at AF000581 nuclear receptor coactivator 39142 0.60967 1.27 up Mm.34637 Catna2 92227_s_at D25281 catenin alpha 29143 0.60973 1.21 down Mm.8534 Egfr 101841_at AW049716 epidermal growth factor receptor9144 0.60979 1.09 down Mm.29828 1810036J22Rik 96261_at AW122694 RIKEN cDNA 1810036J22 gene9145 0.60982 1.20 up Mm.27662 1500011H22Rik 160749_at AI846812 RIKEN cDNA 1500011H22 gene9146 0.60993 1.16 up Mm.1175 Jund1 102364_at J04509 Jun proto-oncogene related gene d19147 0.61024 1.14 down Mm.24443 Gdi3 160114_at L36314 guanosine diphosphate (GDP) dissociation inhibitor 39148 0.61059 1.25 up Mm.2035 Fnbp1 103638_at AW046460 formin binding protein 19149 0.61060 1.63 down Mm.30303 Cyp3a16 101639_r_at D26137 cytochrome P450, 3a169150 0.61081 1.22 up Mm.5110 Ovgp1 102092_s_at C86340 oviductal glycoprotein 1, 120kD9151 0.61087 1.27 down Mm.449 Cidea 99994_at AF041376 cell death-inducing DNA fragmentation factor, alpha subunit-like effector A9152 0.61092 1.37 up Mm.2319 Sclip 160170_at AF069708 Scgn10 like-protein9153 0.61108 1.22 down Mm.45234 Impdh1 98390_at U00978 inosine 5'-phosphate dehydrogenase 19154 0.61150 1.20 down Mm.9911 Kcnn4 102198_at AF042487 potassium intermediate/small conductance calcium-activated channel, subfa9155 0.61166 1.14 up Mm.17087 2210412K09Rik 103076_at AW046093 RIKEN cDNA 2210412K09 gene9156 0.61207 1.38 up Mm.10331 Tnfaip1 93215_at AF061346 tumor necrosis factor, alpha-induced protein 1 (endothelial)9157 0.61214 1.23 down Mm.3909 Smarca3 92344_at AF010600 SWI/SNF related, matrix associated, actin dependent regulator of chromatin,9158 0.61230 1.29 down Mm.4424 Cacna1b 100338_s_at AF042066 calcium channel, voltage-dependent, N type, alpha 1B subunit9159 0.61252 1.36 up Mm.4958 Zfp2 101158_at Y00850 zinc finger protein 29160 0.61256 1.24 up Mm.5174 Tsx 93140_at X99946 <strong>test</strong>is specific X-linked gene9161 0.61268 1.31 up Mm.28060 2310058J06Rik 103100_at AI788543 RIKEN cDNA 2310058J06 gene9162 0.61280 1.12 down Mm.27351 Akap8 95001_at AB028920 A kinase anchor protein 89163 0.61281 1.15 down Mm.3716 Mcrs1 98563_f_at AF015309 microspherule protein 19164 0.61297 1.31 up Mm.29055 Cbx1 160797_r_at AW124869 chromobox homolog 1 (Drosophila HP1 beta)9165 0.61308 1.07 up Mm.1552 Ell 102996_at U80227 eleven-nineteen lysine-rich leukemia gene9166 0.61312 1.23 up Mm.3127 Emu2-pending 97982_at AA260139 Emu2 gene9167 0.61313 1.30 up Mm.3879 Hif1a 98628_f_at AF003695 hypoxia inducible factor 1, alpha subunit9168 0.61318 1.36 up Mm.7280 2310061I09Rik 101404_at AI853654 RIKEN cDNA 2310061I09 gene9169 0.61321 1.48 up Mm.2726 Itpr1 161661_i_at AV256307 inositol 1,4,5-triphosphate receptor 19170 0.61324 1.31 up Mm.7320 Madh3 93613_at AB008192 MAD homolog 3 (Drosophila)9171 0.61335 1.27 up Mm.25849 2010003O14Rik 96036_at AW046036 RIKEN cDNA 2010003O14 gene9172 0.61338 1.22 down Mm.28373 Bag3 161980_f_at AV373612 Bcl2-associated athanogene 39173 0.61364 1.25 up Mm.389 Il7r 99030_at M29697 interleukin 7 receptor9174 0.61376 1.25 up Mm.5936 2010013B02Rik 101609_at C80370 RIKEN cDNA 2010013B02 gene9175 0.61381 1.05 down Mm.28287 AU015605 97911_at AI835950 expressed sequence AU0156059176 0.61388 1.25 up Mm.4454 Elk3 99984_at L19953 ELK3, member of ETS oncogene family9177 0.61391 1.32 up Mm.3794 Stk18 162064_at AV277112 serine/threonine kinase 189178 0.61430 1.19 up Mm.10504 Pdpk1 102063_at AF079535 3-phosphoinositide dependent protein kinase-19179 0.61431 1.11 up Mm.4016 Mm.4016 97743_at AW047461 ESTs, Weakly similar to clipper/cleavage and polyadenylation specificity fact9180 0.61431 1.10 down Mm.29057 2900073G15Rik 94536_s_at AI843417 RIKEN cDNA 2900073G15 genePage 102 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description9181 0.61458 1.17 up Mm.181643 2610025M23Rik 103635_at AI648925 RIKEN cDNA 2610025M23 gene9182 0.61491 1.51 down Mm.10143 Alox12b 102216_at Y14334 arachidonate 12-lipoxygenase, 12R type9183 0.61503 1.09 down Mm.2795 Surf4 96542_at M62606 surfeit gene 49184 0.61506 1.15 up Mm.1196 AW536703 102375_at AI843738 expressed sequence AW5367039185 0.61509 1.18 up Mm.4781 Cyp7b1 161345_f_at AV141027 cytochrome P450, 7b19186 0.61516 1.18 down Mm.19941 Acpp 103219_at AI327518 acid phosphatase, prostate9187 0.61522 1.09 down Mm.1190 Nf2 92643_at X74671 neurofibromatosis 29188 0.61548 1.18 down Mm.31178 1300010C19Rik 94257_at AI836117 RIKEN cDNA 1300010C19 gene9189 0.61557 1.34 down Mm.9238 Nck2 93948_at AF043260 non-catalytic region of tyrosine kinase adaptor protein 29190 0.61583 1.26 down Mm.1441 Nap1l2 102819_at X92352 nucleosome assembly protein 1-like 29191 0.61592 1.19 up Mm.7446 8430417G17Rik 93624_at AI225296 RIKEN cDNA 8430417G17 gene9192 0.61606 1.18 up Mm.28655 1300010A20Rik 104398_at AI846222 RIKEN cDNA 1300010A20 gene9193 0.61611 1.11 up Mm.27901 1110020J08Rik 160256_at AA611709 RIKEN cDNA 1110020J08 gene9194 0.61617 1.30 up Mm.25233 1110001A07Rik 160987_r_at AA738737 RIKEN cDNA 1110001A07 gene9195 0.61643 1.17 up Mm.42242 Isl1 92515_at AJ132765 ISL1 transcription factor, LIM/homeodomain, (islet-1)9196 0.61649 1.22 up Mm.20866 Nbn 103805_at AF092840 nibrin9197 0.61661 1.34 up Mm.27705 Prim2 95549_at D13545 DNA primase, p58 subunit9198 0.61661 1.42 up Mm.29717 Ywhag 102259_at AF058799 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma po9199 0.61676 1.18 up Mm.30052 D4Wsu125e 160381_at AI851505 DNA segment, Chr 4, Wayne State University 125, expressed9200 0.61704 1.26 down Mm.143752 Zfp276 93432_at AW125516 zinc finger protein (C2H2 type) 2769201 0.61722 1.14 down Mm.27094 2310008B08Rik 104158_at AW046671 RIKEN cDNA 2310008B08 gene9202 0.61730 1.15 up Mm.3741 AI414265 161024_at AW212673 expressed sequence AI4142659203 0.61734 1.17 up Mm.30405 Zfp94 161465_r_at AV347674 zinc finger protein 949204 0.61749 1.12 up Mm.1141 Hdgf 92630_r_at D63707 hepatoma-derived growth factor9205 0.61770 1.10 down Mm.3049 Cks1 97468_at AB025409 CDC28 protein kinase 19206 0.61771 1.43 down Mm.103869 Mm.103869 100767_at C80936 ESTs9207 0.61775 1.15 up Mm.181880 1110007A14Rik 101922_at AW123408 RIKEN cDNA 1110007A14 gene9208 0.61804 1.19 up Mm.27687 AA408288 162124_r_at AV305398 expressed sequence AA4082889209 0.61809 1.25 up Mm.1400 Gcm1 94711_at D88612 glial cells missing homolog 1 (Drosophila)9210 0.61850 1.14 down Mm.18718 Scml1 103399_at AI853225 sex comb on midleg-like 1 (Drosophila)9211 0.61887 1.31 down Mm.21757 Trfr2 160674_at AI596094 transferrin receptor 29212 0.61892 1.15 down Mm.21310 Cfdp 93784_at AB010828 craniofacial development protein 19213 0.61925 1.10 up Mm.214981 Hist1 96416_f_at Z30939 histone gene complex 19214 0.61926 1.17 up Mm.16660 P4hb 161926_r_at AV147906 prolyl 4-hydroxylase, beta polypeptide9215 0.61928 1.28 up Mm.25248 AA960558 161027_f_at AI594669 expressed sequence AA9605589216 0.61953 1.54 up Mm.86844 Met 100309_at Y00671 met proto-oncogene9217 0.61954 1.15 up Mm.21109 Gsn 161967_at AV369888 gelsolin9218 0.61958 1.52 up Mm.29921 Rasgrf1 96313_at L20899 RAS protein-specific guanine nucleotide-releasing factor 19219 0.61991 1.33 up Mm.20460 Rgr 95331_at AF076930 retinal G protein coupled receptor9220 0.62002 1.35 up Mm.27743 5730454C12Rik 95554_at AI121864 RIKEN cDNA 5730454C12 gene9221 0.62008 1.32 down Mm.3506 Arg2 161246_at AV313286 arginase type II9222 0.62023 1.35 down Mm.35806 2300002G24Rik 98518_f_at AI604345 RIKEN cDNA 2300002G24 gene9223 0.62034 1.24 up Mm.3395 1110003B01Rik 102845_at AI836034 RIKEN cDNA 1110003B01 gene9224 0.62053 1.35 up Mm.4757 Crabp2 100127_at M35523 cellular retinoic acid binding protein II9225 0.62058 1.30 down Mm.28312 0610039A15Rik 97861_at AA840092 RIKEN cDNA 0610039A15 gene9226 0.62061 1.14 up Mm.28830 Pbef-pending 94461_at AI852144 pre-B-cell colony-enhancing factor9227 0.62079 1.18 up Mm.24542 1110013E13Rik 162190_r_at AV370465 RIKEN cDNA 1110013E13 gene9228 0.62079 1.22 down Mm.5154 F8a 162266_f_at AV359917 factor 8-associated gene A9229 0.62083 1.40 up Mm.6110 Bnc 93371_at U88064 basonuclin9230 0.62099 1.12 up Mm.1508 Bzrp 162338_r_at AV107756 benzodiazepine receptor, peripheral9231 0.62114 1.31 up Mm.30063 Fgb 96868_at AI196896 fibrinogen, B beta polypeptide9232 0.62116 1.34 up Mm.2991 Oprl 104474_s_at AF043276 opioid receptor-like9233 0.62117 1.15 down Mm.5662 C77934 99365_at AA734487 expressed sequence C779349234 0.62121 1.22 up Mm.3502 Krtap14 92246_at D85925 keratin associated protein 149235 0.62124 1.29 up Mm.3655 Rad54l 98971_at X97796 RAD54 like (S. cerevisiae)9236 0.62130 1.31 down Mm.1571 2610005L07Rik 161462_r_at AV346841 RIKEN cDNA 2610005L07 gene9237 0.62140 1.14 down Mm.194795 Mgll 97511_at AI846600 monoglyceride lipase9238 0.62142 1.14 up Mm.28365 4930529O08Rik 97880_at AW061024 RIKEN cDNA 4930529O08 gene9239 0.62144 1.18 down Mm.24222 Sphk2 104619_at AI840424 sphingosine kinase 29240 0.62180 1.12 down Mm.953 Smpd2 101940_at AJ222800 sphingomyelin phosphodiesterase 2, neutral9241 0.62183 1.12 up Mm.6799 Fhl2 100986_at AF055889 four and a half LIM domains 29242 0.62187 1.19 up Mm.42201 Hus1 92504_at AF076845 Hus1 homolog (S. pombe)9243 0.62187 1.23 up Mm.14173 Orm2 94734_at M12566 orosomucoid 29244 0.62197 1.37 up Mm.1245 Ifnb 94145_at K00020 interferon beta, fibroblast9245 0.62208 1.20 up Mm.29823 Mgst3 96258_at AI843448 microsomal glutathione S-transferase 39246 0.62227 1.08 up Mm.218924 AI842275 104042_at AI842275 expressed sequence AI8422759247 0.62238 1.12 down Mm.103581 Slc23a1 104267_at AI844736 solute carrier family 23 (nucleobase transporters), member 19248 0.62264 1.29 up Mm.30367 Cntfr 101651_at AF068615 ciliary neurotrophic factor receptor9249 0.62271 1.35 down Mm.200230 AI848715 92374_at AW120691 expressed sequence AI8487159250 0.62273 1.08 up Mm.28805 Set 98550_at AI854006 SET translocation9251 0.62289 1.11 up Mm.2125 0610006O17Rik 93780_at AW060827 RIKEN cDNA 0610006O17 gene9252 0.62294 1.26 up Mm.1345 Gabrg3 100693_at X59300 gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 39253 0.62296 1.26 up Mm.107715 Mm.107715 100306_at AI510297 ESTs9254 0.62300 1.52 up Mm.16729 Klrb1a 94772_at M77753 killer cell lectin-like receptor subfamily B member 1A9255 0.62313 1.10 down Mm.34388 1110001K21Rik 98061_at AI841192 RIKEN cDNA 1110001K21 gene9256 0.62314 1.35 up Mm.128513 AA410078 100744_at AA410078 expressed sequence AA4100789257 0.62319 1.32 up Mm.24964 C77691 95968_at C77691 expressed sequence C776919258 0.62338 1.18 down Mm.6142 Naglu 93373_at U85247 alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)9259 0.62347 1.41 down Mm.4155 Ros1 97764_at U15443 Ros1 proto-oncogene9260 0.62348 1.12 up Mm.200383 2310016N05Rik 97471_at AI848442 RIKEN cDNA 2310016N05 gene9261 0.62350 1.09 down Mm.28742 D19Bwg1357e 160310_at AW046771 DNA segment, Chr 19, Brigham & Women's Genetics 1357 expressed9262 0.62363 1.18 down Mm.42189 Cldn7 99561_f_at AF087825 claudin 79263 0.62363 1.14 up Mm.142195 2210008F15Rik 160398_at AW124661 RIKEN cDNA 2210008F15 gene9264 0.62364 1.26 down Mm.5360 AW413446 99345_at AI644767 expressed sequence AW4134469265 0.62368 1.15 up Mm.29517 2300004O14Rik 95653_at AI841323 RIKEN cDNA 2300004O14 gene9266 0.62374 1.20 up Mm.28717 BC003993 96222_at AI037577 hypothetical protein, MGC:75319267 0.62374 1.14 down Mm.23263 0610041E09Rik 98615_at AW049570 RIKEN cDNA 0610041E09 gene9268 0.62378 1.12 down Mm.28550 2610016F04Rik 98893_at AW048644 RIKEN cDNA 2610016F04 gene9269 0.62382 1.21 down Mm.89830 Ube2c 161137_r_at AV117844 ubiquitin-conjugating enzyme E2C9270 0.62388 1.43 up Mm.25084 C80678 96388_at C80678 expressed sequence C80678Page 103 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description9271 0.62406 1.10 up Mm.22192 Mm.22192 94084_at AI842888 Mus musculus, clone MGC:12007 IMAGE:3602527, mRNA, complete cds9272 0.62419 1.22 up Mm.30105 F13b 97435_at D10071 coagulation factor XIII, beta subunit9273 0.62430 1.12 down Mm.28833 1200010B10Rik 96725_at AI838398 RIKEN cDNA 1200010B10 gene9274 0.62440 1.25 up Mm.148395 Lamb1-1 101948_at X05212 laminin B1 subunit 19275 0.62449 1.07 up Mm.29897 Mm.29897 96291_f_at AI835847 ESTs, Highly similar to NUMM MOUSE NADH-UBIQUINONE OXIDOREDUC9276 0.62449 1.18 down Mm.188194 C80068 101607_at C80068 expressed sequence C800689277 0.62450 1.32 up Mm.28530 Mm.28530 104266_at AI847795 ESTs, Weakly similar to F59B10.1.p [Caenorhabditis elegans] [C.elegans]9278 0.62474 1.16 down Mm.4093 Top2b 99462_at D38046 topoisomerase (DNA) II beta9279 0.62475 1.08 down Mm.21901 D3Ertd176e 94030_at AI853431 DNA segment, Chr 3, ERATO Doi 176, expressed9280 0.62479 1.31 up Mm.78861 Nolc1 95735_at AW049358 nucleolar and coiled-body phosphoprotein 19281 0.62488 1.17 down Mm.8858 Rora 101889_s_at U53228 RAR-related orphan receptor alpha9282 0.62488 1.28 up Mm.4517 Itih3 100002_at X70393 inter-alpha trypsin inhibitor, heavy chain 39283 0.62515 1.48 up Mm.6655 Tead3 100971_at AJ131526 TEA domain family member 39284 0.62516 1.16 up Mm.29404 Stk39 160806_at AF099988 serine/threonine kinase 39, STE20/SPS1 homolog (yeast)9285 0.62533 1.14 up Mm.4541 Sox2 100009_r_at X94127 SRY-box containing gene 29286 0.62541 1.30 down Mm.2581 Epha2 103980_at U07634 Eph receptor A29287 0.62545 1.23 up Mm.167842 Itgp 103611_at AB012693 integrin-associated protein9288 0.62557 1.30 up Mm.25678 Mid2 103968_at Y18881 midline 29289 0.62558 1.25 down Mm.197537 Mup3 101909_f_at M16357 major urinary protein 39290 0.62566 1.06 up Mm.2171 Atpi 93984_at AF002718 ATPase inhibitor9291 0.62576 1.23 up Mm.143818 Nek6 160846_at AI846534 NIMA (never in mitosis gene a)-related expressed kinase 69292 0.62587 1.25 up 99409_at U926549293 0.62603 1.09 down Mm.144699 Nudt3 101977_at AW121873 nudix (nucleotide diphosphate linked moiety X)-type motif 39294 0.62607 1.13 up Mm.1240 Gh 92783_at X02891 growth hormone9295 0.62612 1.25 up Mm.21855 Pglyrp 104099_at AF076482 peptidoglycan recognition protein9296 0.62614 1.32 up Mm.5419 Il17 99349_at U35108 interleukin 179297 0.62628 1.17 up Mm.88825 Ors16 96985_at AB030895 odorant receptor 169298 0.62652 1.10 down Mm.196005 1110002H14Rik 95086_at AI835392 RIKEN cDNA 1110002H14 gene9299 0.62667 1.21 down Mm.25051 Mm.25051 95990_at C80130 ESTs9300 0.62687 1.45 up Mm.180776 2610318G18Rik 161540_r_at AV350451 RIKEN cDNA 2610318G18 gene9301 0.62699 1.15 up Mm.176927 2610301I15Rik 94008_at AW045358 RIKEN cDNA 2610301I15 gene9302 0.62700 1.29 up Mm.3337 Selp 104692_at M72332 selectin, platelet9303 0.62700 1.27 up Mm.31436 Mrg1 97988_at U68383 myeloid ecotropic viral integration site-related gene 19304 0.62715 1.26 up Mm.22768 Cldn5 104516_at U82758 claudin 59305 0.62729 1.26 up Mm.218274 Mm.218274 93479_at AW122413 ESTs, Weakly similar to TYROSINE-PROTEIN KINASE JAK3 [M.musculus]9306 0.62735 1.28 up 93650_i_at M232369307 0.62740 1.09 up Mm.29952 3300001G02Rik 97412_at AI843157 RIKEN cDNA 3300001G02 gene9308 0.62741 1.13 down Mm.589 Gpi1 100574_f_at L09104 glucose phosphate isomerase 1 complex9309 0.62748 1.12 up Mm.27677 2900002J19Rik 97201_s_at AA823381 RIKEN cDNA 2900002J19 gene9310 0.62748 1.36 up Mm.103551 Tollip-pending 93886_at AJ242971 toll interacting protein9311 0.62753 1.25 up Mm.2969 Akap 97369_g_at U95145 A kinase anchor protein9312 0.62756 1.37 up Mm.38370 Pipk5k3 97712_at AF102777 phosphatidylinositol-4-phosphate 5-kinase, type III9313 0.62801 1.20 up Mm.4392 Il15 161037_at U14332 interleukin 159314 0.62807 1.16 down Mm.196475 Mm.196475 93667_at AW120511 Mus musculus F-box-WD40 repeat protein 6 (Fbxw6) mRNA, complete cds9315 0.62818 1.17 down Mm.20841 2410043G19Rik 93596_i_at AA624586 RIKEN cDNA 2410043G19 gene9316 0.62827 1.21 up Mm.196110 Hba-a1 94781_at V00714 hemoglobin alpha, adult chain 19317 0.62839 1.22 up Mm.137885 Plod3 95009_at AW107836 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 39318 0.62853 1.37 down Mm.27272 AI043088 96638_at AI834899 expressed sequence AI0430889319 0.62888 1.26 down Mm.2496 Ina 94335_r_at L27220 internexin neuronal intermediate filament protein, alpha9320 0.62940 1.29 up Mm.4964 Lif 92960_at X12810 leukemia inhibitory factor9321 0.62984 1.12 down Mm.25228 Rnf11 160205_f_at AB024427 ring finger protein 119322 0.62985 1.39 up Mm.5434 Mm.5434 162098_i_at AV359180 Mus musculus, clone IMAGE:3499034, mRNA, partial cds9323 0.63019 1.41 down Mm.200128 Mm.200128 96584_f_at AF067060 Mus musculus clone L3 variable group of 2-cell-stage gene family mRNA, co9324 0.63019 1.13 down Mm.1131 Npdc1 92626_at X67209 neural proliferation, differentiation and control gene 19325 0.63027 1.30 up Mm.4486 Klk6 100061_f_at M13500 kallikrein 69326 0.63031 1.33 up Mm.44410 Prkg2 98368_at L12460 protein kinase, cGMP-dependent, type II9327 0.63033 1.29 up Mm.1314 Kdt1 102644_at U13371 kidney cell line derived transcript 19328 0.63033 1.24 up Mm.143846 Ptprc 101298_g_at M23158 protein tyrosine phosphatase, receptor type, C9329 0.63050 1.14 up Mm.178 Cryab 160098_s_at AI842724 crystallin, alpha B9330 0.63082 1.25 up Mm.3906 Map2k7 99036_s_at AB005654 mitogen activated protein kinase kinase 79331 0.63098 1.16 up Mm.5111 Foxl1 101185_at X92498 forkhead box L19332 0.63100 1.11 down Mm.27913 2310032M22Rik 92703_at AI325791 RIKEN cDNA 2310032M22 gene9333 0.63108 1.11 down Mm.29594 Sart3 161432_f_at AV306387 squamous cell carcinoma antigen recognized by T-cells 39334 0.63124 1.17 up Mm.43213 9030402K04Rik 97161_at AI451558 RIKEN cDNA 9030402K04 gene9335 0.63126 1.30 up Mm.7411 Hdgfrp1 99869_at D63663 hepatoma-derived growth factor, related protein 19336 0.63141 1.07 down Mm.28536 2810410M20Rik 98886_at AI835412 RIKEN cDNA 2810410M20 gene9337 0.63150 1.32 down Mm.19065 Pscd3 103434_at AF001871 pleckstrin homology, Sec7 and coiled/coil domains 39338 0.63163 1.09 up Mm.658 Slc25a5 100618_f_at AA062013 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocato9339 0.63170 1.11 up Mm.16147 G22p1 103036_at M38700 thyroid autoantigen 70 kDa9340 0.63180 1.09 up Mm.12983 Sfxn1 92831_at AI846308 sideroflexin 19341 0.63194 1.31 down Mm.1287 Mapt 102742_g_at M18775 microtubule-associated protein tau9342 0.63205 1.10 up Mm.28308 Nkx6-2 97858_at AW049190 NK6 transcription factor related, locus 2 (Drosophila)9343 0.63219 1.14 up Mm.27687 AA408288 95544_at AI843150 expressed sequence AA4082889344 0.63262 1.20 down Mm.9394 Nfix 101930_at Y07688 nuclear factor I/X9345 0.63264 1.16 down Mm.24495 2410015A15Rik 95433_at AW049776 RIKEN cDNA 2410015A15 gene9346 0.63277 1.20 up Mm.3868 Yy1 99020_at M74590 YY1 transcription factor9347 0.63316 1.33 up Mm.8041 Atp1b2 93664_at X16645 ATPase, Na+/K+ transporting, beta 2 polypeptide9348 0.63324 1.27 up Mm.21559 Nono 93831_at AI316087 non-POU-domain-containing, octamer binding protein9349 0.63332 1.28 down Mm.1561 Bnip2 161712_r_at AV247900 BCL2/adenovirus E1B 19 kDa-interacting protein 1, NIP29350 0.63347 1.30 up Mm.2774 Dio1 95552_at U49861 deiodinase, iodothyronine, type I9351 0.63368 1.26 up Mm.4691 Nid1 100120_at L17324 nidogen 19352 0.63380 1.26 down Mm.2755 Calb2 95036_at X73985 calbindin 29353 0.63387 1.28 up Mm.1193 Enpep 161155_r_at AV230295 glutamyl aminopeptidase9354 0.63388 1.12 down Mm.29562 X83328 95662_at AW211667 EST X833289355 0.63397 1.15 up Mm.4563 Mtf1 100018_at X71327 metal response element binding transcription factor 19356 0.63417 1.09 down Mm.3792 Hiat1 160447_at D88315 hippocampus abundant gene transcript 19357 0.63419 1.23 up Mm.218 Mns1 103468_at D14849 meiosis-specific nuclear structural protein 19358 0.63436 1.14 down Mm.5388 Mm.5388 160979_at AW120820 ESTs9359 0.63441 1.28 up Mm.25793 Hgn-pending 94402_r_at AI172981 hemogen9360 0.63457 1.22 up Mm.5267 2310061O04Rik 161060_i_at AV338120 RIKEN cDNA 2310061O04 genePage 104 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description9361 0.63482 1.27 up Mm.57041 B3galt1 101725_at AF029790 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 19362 0.63483 1.14 up Mm.57061 Lhb 101738_at U25145 luteinizing hormone beta9363 0.63484 1.20 up Mm.57253 Vax2 99817_at AB020498 ventral anterior homeobox containing gene 29364 0.63491 1.29 up Mm.7688 Kif3c 93635_at AF013116 kinesin family member 3c9365 0.63500 1.25 up Mm.1561 Bnip2 93064_at AF035207 BCL2/adenovirus E1B 19 kDa-interacting protein 1, NIP29366 0.63519 1.24 up Mm.1289 Tcrg-V4 102745_at M18858 T-cell receptor gamma, variable 49367 0.63520 1.30 up Mm.1374 Sn 102669_at Z36293 sialoadhesin9368 0.63526 1.28 up Mm.2525 Npas1 100712_at U77967 neuronal PAS domain protein 19369 0.63544 1.12 up Mm.4426 Cd63 160493_at D16432 Cd63 antigen9370 0.63553 1.21 down Mm.196638 Rab6kifl 104090_at AA657164 Rab6, kinesin-like9371 0.63563 1.10 up Mm.71361 Whsc2h 160616_at AW047201 Wolf-Hirschhorn syndrome candidate 2 homolog (human)9372 0.63603 1.12 down Mm.22040 AW556797 104128_at AW048075 expressed sequence AW5567979373 0.63610 1.32 down Mm.11964 Pcdh7 101796_at AB011255 protocadherin 79374 0.63621 1.12 up Mm.20945 Rgs19ip1 93732_f_at AF104358 regulator of G-protein signaling 19 interacting protein 19375 0.63631 1.40 up Mm.24655 1110059E24Rik 162345_at AV152396 RIKEN cDNA 1110059E24 gene9376 0.63646 1.17 up Mm.21926 D5Ertd40e 103476_at AA674794 DNA segment, Chr 5, ERATO Doi 40, expressed9377 0.63672 1.10 up Mm.28291 C76439 160283_at AW045742 expressed sequence C764399378 0.63674 1.14 down Mm.6628 B4galt3 160915_at AW125175 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 39379 0.63675 1.22 up Mm.181880 1110007A14Rik 162201_r_at AV063960 RIKEN cDNA 1110007A14 gene9380 0.63681 1.20 up Mm.17912 Biklk 93287_at AF048838 Bcl2-interacting killer-like9381 0.63697 1.27 down Mm.1414 Stac 94731_at D86639 src homology three (SH3) and cysteine rich domain9382 0.63707 1.17 up Mm.46641 Mm.46641 100410_at AW122781 Mus musculus, RIKEN cDNA C330027G06 gene, clone IMAGE:4951813, m9383 0.63716 1.13 up Mm.2591 Rbm3 96041_at AB016424 RNA binding motif protein 39384 0.63724 1.24 up Mm.194916 Scca2 101816_at AF063937 squamous cell carcinoma antigen 29385 0.63728 1.20 up Mm.4325 Klf4 99622_at U20344 Kruppel-like factor 4 (gut)9386 0.63730 1.11 up Mm.1980 Hspb2 103215_g_at AW048883 heat shock 27kD protein 29387 0.63738 1.17 up Mm.154045 Tacstd2 103648_at Y08830 tumor-associated calcium signal transducer 29388 0.63738 1.16 down Mm.4210 Aldh3a2 161401_f_at AV276715 aldehyde dehydrogenase family 3, subfamily A29389 0.63752 1.06 up Mm.28893 Mm.28893 96733_at AW124597 Mus musculus, Similar to RAP1, GTP-GDP dissociation stimulator 1, clone M9390 0.63764 1.47 up Mm.216261 Mm.216261 97667_at C79525 EST9391 0.63768 1.24 up Mm.249 AA407055 103784_at AI550305 expressed sequence AA4070559392 0.63770 1.10 down Mm.26614 2310001L22Rik 96082_at AI850644 RIKEN cDNA 2310001L22 gene9393 0.63785 1.47 up Mm.5165 Dlx4 98873_at U73329 distal-less homeobox 49394 0.63787 1.12 down Mm.27858 1110036B12Rik 97250_at AW049326 RIKEN cDNA 1110036B12 gene9395 0.63822 1.28 up Mm.29798 Cd34 97773_at AI173145 CD34 antigen9396 0.63838 1.20 down Mm.13828 Wisp2 94704_at AF100778 WNT1 inducible signaling pathway protein 29397 0.63861 1.16 down Mm.42166 Stap-pending 98311_at AB029919 sperm tail associated protein9398 0.63863 1.14 up Mm.3587 2700007P21Rik 92268_at AI854851 RIKEN cDNA 2700007P21 gene9399 0.63880 1.25 up Mm.1376 Creb1 102671_at X67719 cAMP responsive element binding protein 19400 0.63888 1.27 up Mm.4936 Mapk10 161575_f_at AV280750 mitogen activated protein kinase 109401 0.63895 1.22 up Mm.3820 Cmas 161138_r_at AV174251 cytidine monophospho-N-acetylneuraminic acid synthetase9402 0.63895 1.15 up Mm.27738 1700020M16Rik 95551_at AI849232 RIKEN cDNA 1700020M16 gene9403 0.63897 1.19 down Mm.5675 C78076 99366_at AI553536 expressed sequence C780769404 0.63902 1.15 down Mm.135498 0610010K06Rik 96079_at AI853881 RIKEN cDNA 0610010K06 gene9405 0.63930 1.17 down Mm.2209 Cd4 99045_at AC002397 CD4 antigen9406 0.63932 1.13 down Mm.183110 Tk2 101356_at AI843384 thymidine kinase 2, mitochondrial9407 0.63935 1.21 down Mm.29372 0610039D01Rik 95113_at AW124257 RIKEN cDNA 0610039D01 gene9408 0.63952 1.16 up Mm.2655 qk 95096_at AI846695 quaking9409 0.63955 1.11 down Mm.24148 AI465155 104296_at AI847802 expressed sequence AI4651559410 0.63966 1.16 up Mm.23653 Pus1 103544_at AI839083 pseudouridine synthase 19411 0.63989 1.40 up Mm.46801 Mm.46801 96970_at X16740 M.musculus mRNA (2F7) for IgA V-D-J-heavy chain9412 0.64009 1.16 down Mm.613 Anp32 93372_at U73478 acidic nuclear phosphoprotein 329413 0.64015 1.34 up Mm.200869 AI047775 101377_at AI853175 expressed sequence AI0477759414 0.64031 1.14 down Mm.4773 Il18r1 101144_at U43673 interleukin 18 receptor 19415 0.64055 1.26 down Mm.41930 Fxr2h 99516_at AB025311 fragile X mental retardation gene 2, autosomal homolog9416 0.64057 1.42 up Mm.14046 Krt1-17 92862_f_at M13805 keratin complex 1, acidic, gene 179417 0.64068 1.15 up Mm.757 Arha2 101112_g_at AF014371 ras homolog A29418 0.64095 1.10 down Mm.27941 Fkbp1a 160257_at X60203 FK506 binding protein 1a (12 kDa)9419 0.64099 1.45 up Mm.103861 Mm.103861 100350_at C80925 ESTs9420 0.64108 1.28 up Mm.24991 D1Ertd164e 95871_at C78292 DNA segment, Chr 1, ERATO Doi 164, expressed9421 0.64121 1.20 up Mm.3841 Cox8b 160851_r_at U15541 cytochrome c oxidase, subunit VIIIb9422 0.64149 1.23 up Mm.57154 C1qrf-pending 101809_at AF095155 C1q related factor9423 0.64156 1.34 up Mm.4687 Grpr 98781_at U84265 gastrin releasing peptide receptor9424 0.64168 1.43 up Mm.13325 Mm.13325 94693_at C79135 ESTs9425 0.64171 1.19 up Mm.11815 AU019516 160589_at AI854234 expressed sequence AU0195169426 0.64173 1.30 up Mm.31123 C78960 161588_r_at AV321877 expressed sequence C789609427 0.64176 1.20 up Mm.22455 1110025G12Rik 104325_at AI461631 RIKEN cDNA 1110025G12 gene9428 0.64196 1.19 up Mm.12239 Geminin-pending 160069_at AA681520 geminin9429 0.64198 1.42 down Mm.4254 Tshr 98328_at U02602 thyroid stimulating hormone, receptor9430 0.64202 1.33 up Mm.2772 Myh8 160243_r_at M12289 myosin, heavy polypeptide 8, skeletal muscle, perinatal9431 0.64205 1.19 up Mm.193443 Klk13 100334_f_at X58628 kallikrein 139432 0.64207 1.20 up Mm.18626 Capg 161969_f_at AV225548 capping protein (actin filament), gelsolin-like9433 0.64244 1.28 up Mm.28217 Epb4.1l4b 96143_at AA839765 erythrocyte protein band 4.1-like 4b9434 0.64249 1.22 up Mm.25062 Mm.25062 96373_at C80138 ESTs9435 0.64266 1.19 down Mm.175173 Rnase4 96038_at AI840339 ribonuclease, RNase A family 49436 0.64279 1.12 down Mm.85892 1110020A23Rik 95636_at AW123628 RIKEN cDNA 1110020A23 gene9437 0.64280 1.14 up Mm.57066 Bcl2l11 99418_at AF032459 BCL2-like 11 (apoptosis facilitator)9438 0.64284 1.38 up Mm.3914 Slc12a1 99094_at U20973 solute carrier family 12, member 19439 0.64317 1.21 up Mm.16520 Gfra3 102926_at AB008833 glial cell line derived neurotrophic factor family receptor alpha 39440 0.64334 1.16 up 97572_at AF0710799441 0.64337 1.22 up Mm.30136 D8Wsu96e 96907_at AW125538 DNA segment, Chr 8, Wayne State University 96, expressed9442 0.64384 1.24 up Mm.79067 1700014P03Rik 162220_r_at AV111954 RIKEN cDNA 1700014P03 gene9443 0.64395 1.05 down Mm.196479 1810030E20Rik 162013_f_at AV248461 RIKEN cDNA 1810030E20 gene9444 0.64433 1.43 up Mm.57090 Fut2 101760_at AF064792 fucosyltransferase 29445 0.64443 1.15 up Mm.119781 Fli1 94698_at X59421 Friend leukemia integration 19446 0.64445 1.16 down Mm.4379 Pcnt 99663_g_at AI194767 pericentrin9447 0.64452 1.26 up Mm.46816 V1rb5 102166_g_at Y17566 vomeronasal 1 receptor, B59448 0.64452 1.28 up Mm.5180 Nr0b1 93141_at U41568 nuclear receptor subfamily 0, group B, member 19449 0.64460 1.26 up Mm.214491 Pld1 92475_g_at AF083497 phospholipase D19450 0.64485 1.25 down Mm.24916 Mm.24916 95950_at C76551 ESTs, Weakly similar to A53798 58K membrane-associated protein - rat [R.nPage 105 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description9451 0.64511 1.29 up Mm.158904 2900006F19Rik 101440_at AW047074 RIKEN cDNA 2900006F19 gene9452 0.64527 1.30 up Mm.1344 Gata1 102654_at X15763 GATA binding protein 19453 0.64533 1.35 up Mm.22150 Il1b 103486_at M15131 interleukin 1 beta9454 0.64535 1.30 up Mm.4438 Hmga1 162072_at AV311953 high mobility group AT-hook 19455 0.64580 1.26 up Mm.195088 V2r3 100678_s_at AF011413 vomeronasal 2, receptor, 39456 0.64580 1.11 up Mm.9210 Mm.9210 101956_at AI834849 Mus musculus, Similar to cytoskeleton-associated protein 4, clone IMAGE:539457 0.64582 1.11 down Mm.200850 C81439 95531_at AI854771 expressed sequence C814399458 0.64589 1.16 down Mm.15568 Pou2f1 102894_g_at X68363 POU domain, class 2, transcription factor 19459 0.64590 1.20 down Mm.219668 2610209F03Rik 101524_at AI851595 RIKEN cDNA 2610209F03 gene9460 0.64596 1.29 down Mm.4632 Lcn3 101133_at D38580 lipocalin 39461 0.64612 1.16 down Mm.28785 Pcdh13 94449_at AI854522 protocadherin 139462 0.64613 1.16 down Mm.25994 Mm.25994 96045_at AW050142 Mus musculus, Similar to hypothetical protein DKFZp564O1664, clone MGC9463 0.64618 1.21 up Mm.1781 Lcp2 102957_at U20159 lymphocyte cytosolic protein 29464 0.64626 1.17 up Mm.23682 4930453N24Rik 94861_at AA624073 RIKEN cDNA 4930453N24 gene9465 0.64637 1.23 up Mm.14111 Klra5 100673_f_at U10091 killer cell lectin-like receptor, subfamily A, member 59466 0.64660 1.14 down Mm.196581 Mapk1 93253_at D87271 mitogen activated protein kinase 19467 0.64665 1.13 up Mm.30122 Mm.30122 97918_at AA623587 Mus musculus, Similar to hypothetical gene LOC133157, clone IMAGE:39919468 0.64686 1.19 up Mm.5188 Wnt3 99325_at M32502 wingless-related MMTV integration site 39469 0.64702 1.13 up Mm.1777 Hsp60 93277_at X53584 heat shock protein, 60 kDa9470 0.64707 1.15 up Mm.33962 Crlf3 98415_at AF046060 cytokine receptor-like factor 39471 0.64717 1.40 down Mm.595 Bmp7 161461_at AV346015 bone morphogenetic protein 79472 0.64725 1.26 up Mm.41760 R75254 104411_at AA839770 expressed sequence R752549473 0.64739 1.12 up Mm.18714 AW123232 103398_at AW123232 expressed sequence AW1232329474 0.64750 1.14 down Mm.173831 1810010K08Rik 94471_r_at AW045974 RIKEN cDNA 1810010K08 gene9475 0.64755 1.17 up Mm.156264 Csf2ra 99330_at M85078 colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macroph9476 0.64757 1.13 up Mm.3437 Pald 98432_at X99384 paladin9477 0.64760 1.08 down Mm.21126 AI447817 100297_at AA693125 expressed sequence AI4478179478 0.64761 1.26 up Mm.46794 Ifna9 102148_f_at M13660 interferon alpha family, gene 99479 0.64776 1.20 up Mm.12832 Zfp61 102303_i_at L28167 zinc finger protein 619480 0.64784 1.30 down Mm.172556 Amel 94707_s_at M10095 amelogenin9481 0.64794 1.38 up Mm.157442 Mm.157442 98582_at U58988 Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, c9482 0.64796 1.12 down Mm.25575 Matr3 96012_f_at AI835367 matrin 39483 0.64810 1.30 up Mm.88777 Fts 101893_r_at Z67963 fused toes9484 0.64814 1.13 down Mm.30018 Mm.30018 96841_at AW046627 Mus musculus, serine threonine kinase pim3, clone MGC:27707 IMAGE:4929485 0.64814 1.32 up Mm.212716 Mm.212716 97009_f_at L33937 Mus musculus mRNA for immunoglobulin heavy chain, mAb 6679486 0.64815 1.28 down Mm.13979 Krtap8-1 102793_at D86423 keratin associated protein 8-19487 0.64818 1.30 down Mm.204205 AA517858 95249_at AA517858 expressed sequence AA5178589488 0.64823 1.21 up Mm.28484 Tm4sf8-pending 97912_at AI843488 transmembrane 4 superfamily member 89489 0.64824 1.23 up Mm.21597 AI115348 104066_at AI842192 expressed sequence AI1153489490 0.64843 1.07 up Mm.6436 AI449016 99851_at AA172988 expressed sequence AI4490169491 0.64860 1.30 up Mm.371 Il4 92284_r_at X03532 interleukin 49492 0.64862 1.11 down Mm.21954 2310050N11Rik 104114_at AW122450 RIKEN cDNA 2310050N11 gene9493 0.64867 1.14 down Mm.176758 Mm.176758 162229_at AV128236 EST9494 0.64871 1.12 down Mm.26775 Mrpl36 96098_at AI848416 mitochondrial ribosomal protein L369495 0.64884 1.08 down Mm.205791 Atp1a1 93798_at AI839988 ATPase, Na+/K+ transporting, alpha 1 polypeptide9496 0.64885 1.18 down Mm.57202 Shh 101831_at X76290 sonic hedgehog homolog, (Drosophila)9497 0.64910 1.13 up Mm.212712 Iap 97181_f_at M10062 intracisternal A particles9498 0.64913 1.07 down Mm.21623 1110029G07Rik 93843_at AI845580 RIKEN cDNA 1110029G07 gene9499 0.64918 1.32 up Mm.200453 Defcr16 95766_f_at U03066 defensin related cryptdin 169500 0.64930 1.19 down Mm.1469 Ptpn12 102840_at X63440 protein tyrosine phosphatase, non-receptor type 129501 0.64940 1.25 up Mm.2582 Vps45 162110_f_at AV365676 vacuolar protein sorting 45 (yeast)9502 0.64954 1.25 down Mm.140761 Dnajc5 93211_at AF032115 DnaJ (Hsp40) homolog, subfamily C, member 59503 0.64961 1.22 down Mm.4491 Prpmp5-pending 98383_r_at X63004 proline-rich protein MP59504 0.64975 1.16 down Mm.23470 Mm.23470 162133_at AV342910 ESTs9505 0.64983 1.23 up Mm.182149 Dhcr7 98989_at AF057368 7-dehydrocholesterol reductase9506 0.65022 1.20 up Mm.40661 9030412M04Rik 94771_at AA178600 RIKEN cDNA 9030412M04 gene9507 0.65036 1.34 up Mm.142348 Mm.142348 162151_i_at AV329014 ESTs9508 0.65036 1.41 down Mm.1160 AI597080 160586_r_at AI606103 expressed sequence AI5970809509 0.65058 1.11 up Mm.35705 Wig1 92262_at AF012923 wild-type p53-induced gene 19510 0.65068 1.30 down Mm.56895 D17H6S56E-3 98286_at AF109905 DNA segment, Chr 17, human D6S56E 39511 0.65084 1.30 up Mm.41441 5830443C21Rik 103508_at AA919750 RIKEN cDNA 5830443C21 gene9512 0.65115 1.26 up Mm.2529 Phex 96502_at U75646 phosphate regulating neutral endopeptidases on the X chromosome9513 0.65127 1.12 up Mm.162 Mafk 93406_at AB009693 v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)9514 0.65139 1.20 down Mm.10119 Prx 102214_at AJ222969 periaxin9515 0.65139 1.22 up Mm.193086 Mm.193086 160405_at AI842657 Mus musculus, Similar to RIKEN cDNA 1500041N16 gene, clone MGC:12069516 0.65153 1.21 up Mm.27015 Foxd1 160996_at L38607 forkhead box D19517 0.65203 1.25 down Mm.3899 Hcngp-pending 92334_at AF001895 transcriptional regulator protein9518 0.65213 1.41 up Mm.18802 1300017J02Rik 103407_at AA895838 RIKEN cDNA 1300017J02 gene9519 0.65224 1.17 down Mm.24046 AI854770 161707_f_at AV244470 expressed sequence AI8547709520 0.65234 1.16 up Mm.35829 edr 98525_f_at AJ007909 erythroid differentiation regulator9521 0.65249 1.31 down Mm.157893 Mup1 101910_f_at M16359 major urinary protein 19522 0.65261 1.37 up Mm.157012 Tcrb-V13 101043_f_at AE000664 T-cell receptor beta, variable 139523 0.65278 1.29 up Mm.4316 Arnt 92529_s_at U10325 aryl hydrocarbon receptor nuclear translocator9524 0.65294 1.24 up Mm.34079 Impa2 98420_at AA919924 inositol (myo)-1(or 4)-monophosphatase 29525 0.65300 1.10 up Mm.3752 Ranbp1 98573_r_at X56045 RAN binding protein 19526 0.65312 1.12 up Mm.22351 2610001E06Rik 104301_at AI852414 RIKEN cDNA 2610001E06 gene9527 0.65322 1.25 up Mm.24933 C77068 95956_at C76923 expressed sequence C770689528 0.65322 1.24 up Mm.3170 Papola 97996_at U58134 poly (A) polymerase alpha9529 0.65322 1.18 up Mm.6979 Dnmt2 93470_at AF012129 DNA methyltransferase 29530 0.65328 1.15 up Mm.19992 Ttrap-pending 93538_at AW228036 Traf and Tnf receptor associated protein9531 0.65337 1.11 down Mm.28537 Scamp2 104365_at AW046162 secretory carrier membrane protein 29532 0.65352 1.27 down Mm.213458 Mm.213458 93223_at X06307 Mouse T-cell receptor rearranged alpha-chain mRNA V-J-C region, 3' end9533 0.65367 1.41 up Mm.19133 Aplp2 162224_r_at AV313336 amyloid beta (A4) precursor-like protein 29534 0.65374 1.19 up Mm.27886 2410011G03Rik 97256_at AI845291 RIKEN cDNA 2410011G03 gene9535 0.65376 1.15 up Mm.7257 Hspg2 101399_at M77174 perlecan (heparan sulfate proteoglycan 2)9536 0.65386 1.47 down Mm.5348 1700010P14Rik 162304_r_at AV041089 RIKEN cDNA 1700010P14 gene9537 0.65416 1.11 down Mm.21952 Erh 94040_at D73368 enhancer of rudimentary homolog (Drosophila)9538 0.65419 1.13 down Mm.27041 Map3k3 94947_g_at U43187 mitogen activated protein kinase kinase kinase 39539 0.65419 1.10 up Mm.34774 3110004O18Rik 94005_at AI157548 RIKEN cDNA 3110004O18 gene9540 0.65425 1.33 down Mm.29080 1810074H01Rik 96783_at AA683966 RIKEN cDNA 1810074H01 genePage 106 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description9541 0.65468 1.09 down Mm.38521 2700085E05Rik 98613_at AI849876 RIKEN cDNA 2700085E05 gene9542 0.65480 1.19 up Mm.206770 Cnot7 101564_at U21855 CCR4-NOT transcription complex, subunit 79543 0.65482 1.11 down Mm.1725 C87777 102944_at AI850849 expressed sequence C877779544 0.65491 1.27 down Mm.2578 F10 103977_at AF087644 coagulation factor X9545 0.65498 1.21 up Mm.10696 Nrg1 98314_g_at AB025413 neuregulin 19546 0.65500 1.11 down Mm.4341 Pvs 99933_at D26107 poliovirus sensitivity9547 0.65502 1.10 down Mm.144028 U2af1 97486_at AA693246 U2 small nuclear ribonucleoprotein auxiliary factor (U2AF),35 kDa9548 0.65527 1.20 down Mm.43 Myla 160487_at M19436 myosin light chain, alkali, cardiac atria9549 0.65529 1.24 up Mm.178 Cryab 93279_at M63170 crystallin, alpha B9550 0.65550 1.21 down Mm.21975 Mm.21975 103478_at AI846673 ESTs, Weakly similar to AF167320 1 zinc finger protein ZFP113 [M.musculu9551 0.65553 1.26 up Mm.35814 Il11 92266_at U03421 interleukin 119552 0.65581 1.18 down Mm.999 Mpv17 102202_s_at M36411 Mpv17 transgene, kidney disease mutant9553 0.65582 1.23 up Mm.8001 Gprc1h 94622_at U17252 G protein-coupled receptor, family C, group 1, member H9554 0.65595 1.08 up Mm.30069 1200003J11Rik 96874_g_at AI843287 RIKEN cDNA 1200003J11 gene9555 0.65599 1.11 up Mm.14894 Pgcp-pending 93039_at AF009513 plasma glutamate carboxypeptidase9556 0.65608 1.17 up Mm.4936 Mapk10 100470_at L35236 mitogen activated protein kinase 109557 0.65609 1.16 up Mm.29707 Pcbp4 160352_at AI846470 poly(rC) binding protein 49558 0.65609 1.17 down Mm.212672 S100b 101467_at L22144 S100 protein, beta polypeptide, neural9559 0.65611 1.26 up Mm.45656 Mm.45656 161647_f_at AV087536 ESTs9560 0.65626 1.17 down Mm.3596 Cops2 98540_g_at AF071312 COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thal9561 0.65635 1.21 up Mm.89123 Emb 101560_at AW061330 embigin9562 0.65673 1.21 up Mm.30039 Prkar1a 96852_at AW122197 protein kinase, cAMP dependent regulatory, type I, alpha9563 0.65674 1.33 up Mm.3825 Il7 97709_at X07962 interleukin 79564 0.65698 1.14 up Mm.29974 4733401F03Rik 96335_at AI181308 RIKEN cDNA 4733401F03 gene9565 0.65713 1.30 down Mm.16423 Rpl35 93098_at AA538391 ribosomal protein L359566 0.65733 1.12 up Mm.27161 Rage 104166_at AB022695 renal tumor antigen9567 0.65739 1.25 up Mm.202316 W51672 98792_at W51672 expressed sequence W516729568 0.65760 1.06 down Mm.29241 AA407659 104434_at AW048552 expressed sequence AA4076599569 0.65764 1.17 up Mm.3464 Flt1 98452_at D88689 FMS-like tyrosine kinase 19570 0.65791 1.12 up Mm.4481 Il17r 99992_at AI286698 interleukin 17 receptor9571 0.65825 1.32 down Mm.30052 D4Wsu125e 161664_at AV131453 DNA segment, Chr 4, Wayne State University 125, expressed9572 0.65851 1.11 up Mm.3833 Rangap1 98602_at U08110 RAN GTPase activating protein 19573 0.65851 1.21 up Mm.57196 Adra2b 99802_at M94583 adrenergic receptor, alpha 2b9574 0.65852 1.15 down Mm.141867 Timm8b 97477_at AW124594 translocase of inner mitochondrial membrane 8 homolog b (yeast)9575 0.65859 1.08 up Mm.28818 AI462493 94459_at AA681764 expressed sequence AI4624939576 0.65868 1.25 down Mm.43660 Ppt 99646_at AF071025 palmitoyl-protein thioesterase9577 0.65875 1.08 down Mm.41637 2310002N04Rik 99497_at AI852332 RIKEN cDNA 2310002N04 gene9578 0.65897 1.33 up Mm.18218 Gdap1 102967_at Y17850 ganglioside-induced differentiation-associated-protein 19579 0.65900 1.15 down Mm.1993 Cflar 103217_at Y14041 CASP8 and FADD-like apoptosis regulator9580 0.65904 1.13 down Mm.3987 Lama2 92366_at U12147 laminin, alpha 29581 0.65924 1.27 down Mm.45874 Slc7a9 92699_at AJ249198 solute carrier family 7 (cationic amino acid transporter, y+ system), member9582 0.65935 1.21 down Mm.20358 Cdx2 103239_at U00454 caudal type homeo box 29583 0.65950 1.15 up Mm.57225 Gpx2 99810_at X91864 glutathione peroxidase 29584 0.65951 1.11 up Mm.23982 AU015179 104584_f_at AI845823 expressed sequence AU0151799585 0.65955 1.25 up Mm.4361 Calca 92533_at X97991 calcitonin/calcitonin-related polypeptide, alpha9586 0.65960 1.23 up Mm.10301 Pik3c2g 94108_at AB008791 phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide9587 0.65963 1.25 up Mm.45211 Syt9 100363_at AB026802 synaptotagmin 99588 0.65983 1.08 down Mm.30056 1110014J01Rik 160382_at AI845353 RIKEN cDNA 1110014J01 gene9589 0.66003 1.26 down Mm.4425 Cldn11 100044_at U19582 claudin 119590 0.66029 1.23 up Mm.141646 Upa 99118_at U28486 uterine-specific proline-rich acidic protein9591 0.66030 1.15 up Mm.21876 5730488L07Rik 103473_at AA623401 RIKEN cDNA 5730488L07 gene9592 0.66048 1.14 up Mm.200916 Ugt1a6 99580_s_at U16818 UDP glycosyltransferase 1 family, polypeptide A69593 0.66048 1.29 up Mm.4427 Itgav 98366_at U14135 integrin alpha V9594 0.66096 1.13 down Mm.30242 Ppid 97445_at AW122022 peptidylprolyl isomerase D (cyclophilin D)9595 0.66100 1.16 up Mm.28935 Dpt 96742_at AA717826 dermatopontin9596 0.66107 1.21 up Mm.41982 Rs1h 101702_at AJ011381 retinoschisis 1 homolog (human)9597 0.66109 1.13 up Mm.25231 4932441P04Rik 104183_at AI529005 RIKEN cDNA 4932441P04 gene9598 0.66111 1.30 up Mm.177761 Clcn2 92385_at AI847270 chloride channel 29599 0.66134 1.27 up Mm.66 Rps4x 162498_r_at AV167283 ribosomal protein S4, X-linked9600 0.66142 1.22 up Mm.1344 Gata1 161456_f_at AV296708 GATA binding protein 19601 0.66144 1.26 up Mm.28095 AL024016 161223_r_at AV271299 expressed sequence AL0240169602 0.66148 1.12 down Mm.30005 1110021D01Rik 96353_at AW125346 RIKEN cDNA 1110021D01 gene9603 0.66153 1.23 down Mm.3810 Pik3c2a 92311_s_at U52193 phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide9604 0.66155 1.24 up Mm.9010 Ptprg 93936_at L09562 protein tyrosine phosphatase, receptor type, G9605 0.66156 1.11 down Mm.29889 1190002C06Rik 96288_at AI648831 RIKEN cDNA 1190002C06 gene9606 0.66165 1.26 up Mm.218598 Mm.218598 162161_r_at AV340322 ESTs9607 0.66174 1.33 up Mm.57230 Neurod3 161069_at AI323358 neurogenic differentiation 39608 0.66184 1.10 up Mm.25903 Nab1 94408_at U47008 Ngfi-A binding protein 19609 0.66185 1.29 down Mm.41842 Cacna1a 92445_at U76716 calcium channel, voltage-dependent, P/Q type, alpha 1A9610 0.66204 1.22 up Mm.115124 Brp14 100458_at X61450 brain protein 149611 0.66206 1.25 up Mm.39725 Nttp1 161171_at AV226788 neuronal tyrosine/threonine phosphatase 19612 0.66219 1.19 up Mm.25079 Mm.25079 96000_at C80606 ESTs, Highly similar to VPP1_MOUSE VACUOLAR PROTON TRANSLOCA9613 0.66220 1.22 down Mm.21489 AU021774 104046_at AI854141 expressed sequence AU0217749614 0.66223 1.23 up Mm.1215 Crybb2 100688_at M60559 crystallin, beta B29615 0.66300 1.20 down Mm.28734 Btrc 160790_s_at AI746365 beta-transducin repeat containing protein9616 0.66309 1.09 up Mm.21671 D5Wsu45e 93973_at AI854624 DNA segment, Chr 5, Wayne State University 45, expressed9617 0.66316 1.10 down Mm.2500 Mm.2500 160198_at AI842562 ESTs, Weakly similar to KHL1_MOUSE Kelch-like protein 1 [M.musculus]9618 0.66324 1.20 down Mm.205010 2810031L11Rik 160134_at AI841275 RIKEN cDNA 2810031L11 gene9619 0.66337 1.19 up Mm.192224 Zfp36 92830_s_at X14678 zinc finger protein 369620 0.66368 1.14 down Mm.26787 Aox1 104011_at AB017482 aldehyde oxidase 19621 0.66377 1.35 down Mm.34988 Exo1 92244_at AJ238213 exonuclease 19622 0.66379 1.16 up Mm.34446 Cdkn1a 98067_at U09507 cyclin-dependent kinase inhibitor 1A (P21)9623 0.66395 1.08 up Mm.202311 Gna13 100514_at M63660 guanine nucleotide binding protein, alpha 139624 0.66397 1.08 down Mm.34465 Cutl1 98073_at U66249 cut-like 1 (Drosophila)9625 0.66398 1.24 up Mm.21964 AU016842 101662_at AA536986 expressed sequence AU0168429626 0.66410 1.27 down Mm.25988 Bcl2l10 162021_r_at AV362784 Bcl2-like 109627 0.66417 1.14 down Mm.985 Ptpn2 101996_at M80739 protein tyrosine phosphatase, non-receptor type 29628 0.66461 1.26 up Mm.24662 S100a1 95452_i_at AF087687 S100 calcium binding protein A19629 0.66467 1.12 down Mm.2103 Ccng 160127_at L49507 cyclin G9630 0.66469 1.27 up Mm.40996 Pclo 97753_at Y19186 piccolo (presynaptic cytomatrix protein)Page 107 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description9631 0.66477 1.28 down Mm.27625 Mm.27625 96536_at AI596540 ESTs9632 0.66501 1.42 up Mm.45050 Fzd1 161040_at AF054623 frizzled homolog 1, (Drosophila)9633 0.66502 1.30 down Mm.12838 Cyp2j5 92814_at AI114881 cytochrome P450, 2j59634 0.66511 1.33 up Mm.88818 Syt6 100364_at AB026803 synaptotagmin 69635 0.66512 1.18 down Mm.31229 2510022D24Rik 160810_r_at AI844130 RIKEN cDNA 2510022D24 gene9636 0.66513 1.13 down Mm.28392 Deaf1 96171_at AF102818 deformed epidermal autoregulatory factor 1 (Drosophila)9637 0.66518 1.13 up Mm.22491 0910001J09Rik 94274_at AI837415 RIKEN cDNA 0910001J09 gene9638 0.66521 1.15 up Mm.210336 Lgals6 160099_at AF026799 lectin, galactose binding, soluble 69639 0.66526 1.24 up Mm.89197 Theg 93897_at AJ011834 <strong>test</strong>icular haploid expressed gene9640 0.66529 1.12 down Mm.20354 Klc1 97985_f_at AA709672 kinesin light chain 19641 0.66540 1.19 up Mm.1230 Pnliprp2 160070_at M30687 pancreatic lipase-related protein 29642 0.66544 1.36 down Mm.14547 Mm.14547 102834_at AA547587 ESTs, Weakly similar to A39634 probable cell cycle control protein crn - fruit9643 0.66571 1.13 up Mm.2986 AW146116 96276_r_at AI843327 expressed sequence AW1461169644 0.66581 1.33 up Mm.2266 Apoh 94318_at Y11356 apolipoprotein H9645 0.66597 1.12 down Mm.34606 2610511F02Rik 160427_at AW046323 RIKEN cDNA 2610511F02 gene9646 0.66634 1.27 up Mm.2402 Rhoip3-pending 162066_f_at AV277546 Rho interacting protein 39647 0.66654 1.41 up Mm.140173 Defcr5 99551_f_at U12560 defensin related cryptdin 59648 0.66657 1.35 up Mm.23880 3110052F15Rik 162436_at AV345174 RIKEN cDNA 3110052F15 gene9649 0.66670 1.14 down Mm.7086 4931426K16Rik 93475_at AI845581 RIKEN cDNA 4931426K16 gene9650 0.66676 1.27 down Mm.3088 Asph 161015_at AI845273 aspartate-beta-hydroxylase9651 0.66686 1.17 up Mm.141773 1200009I24Rik 101366_f_at AA250299 RIKEN cDNA 1200009I24 gene9652 0.66705 1.13 down Mm.3268 Ube2i 97530_at U82627 ubiquitin-conjugating enzyme E2I9653 0.66722 1.23 up Mm.9093 Strn 100761_at AJ223777 striatin9654 0.66764 1.13 up Mm.218744 1700012P16Rik 161772_i_at AV341773 RIKEN cDNA 1700012P16 gene9655 0.66787 1.39 up Mm.1668 Fmo5 162259_f_at AV341520 flavin containing monooxygenase 59656 0.66791 1.16 up Mm.4067 Lisch7-pending 162274_f_at AV366567 liver-specific bHLH-Zip transcription factor9657 0.66798 1.25 up Mm.177734 1110002E23Rik 96685_at AW121774 RIKEN cDNA 1110002E23 gene9658 0.66810 1.10 up Mm.41972 Phxr4 101700_at X12806 per-hexamer repeat gene 49659 0.66832 1.16 down Mm.27432 Dnajb9 96679_at AW120711 DnaJ (Hsp40) homolog, subfamily B, member 99660 0.66844 1.17 up Mm.39093 Shox2 99043_s_at U65072 short stature homeobox 29661 0.66850 1.06 down Mm.181490 AA959893 98075_at AW121683 expressed sequence AA9598939662 0.66858 1.22 down Mm.26096 Akp5 102132_i_at AU018201 alkaline phosphatase 59663 0.66863 1.23 up Mm.4705 Cplx2 98782_at D38613 complexin 29664 0.66870 1.31 up Mm.27652 AU015195 95532_at AA691059 expressed sequence AU0151959665 0.66900 1.16 down Mm.20884 Rasgrp2 103282_at U78171 RAS, guanyl releasing protein 29666 0.66922 1.05 down Mm.3400 Dvl 98418_at U10115 dishevelled, dsh homolog (Drosophila)9667 0.66933 1.33 up Mm.18630 Acadvl 93334_at Y11770 acyl-Coenzyme A dehydrogenase, very long chain9668 0.66937 1.10 down Mm.2338 Glns 94852_at U09114 glutamine synthetase9669 0.66939 1.12 up Mm.4700 Ercc1 100424_at X07414 excision repair cross-complementing rodent repair deficiency, complementat9670 0.66942 1.09 up Mm.2701 Dnajb6 104625_at AA874130 DnaJ (Hsp40) homolog, subfamily B, member 69671 0.66951 1.17 up Mm.15629 Hgf 102898_at X72307 hepatocyte growth factor9672 0.66965 1.18 up Mm.4278 Kcnj9 98332_at U11860 potassium inwardly-rectifying channel, subfamily J, member 99673 0.66981 1.27 up Mm.27806 Pygm 160754_at AI850363 muscle glycogen phosphorylase9674 0.66990 1.14 up Mm.2861 Slc1a2 96202_at U75372 solute carrier family 1, member 29675 0.66991 1.37 up Mm.4584 Alox15 98758_at L34570 arachidonate 15-lipoxygenase9676 0.67001 1.18 up Mm.21454 Cbr2 93808_at D26123 carbonyl reductase 29677 0.67015 1.16 up Mm.8154 Impact 101501_r_at D87973 imprinted and ancient9678 0.67019 1.22 up Mm.8655 Mm.8655 101853_f_at M12660 Mus musculus complement component factor h (Cfh), mRNA9679 0.67019 1.25 down Mm.1346 Itga4 95292_at AA189389 integrin alpha 49680 0.67027 1.29 down Mm.120807 Ces3 101539_f_at AW226939 carboxylesterase 39681 0.67039 1.14 up Mm.5121 Pam 100496_at U79523 peptidylglycine alpha-amidating monooxygenase9682 0.67054 1.11 up Mm.21420 AA408729 93804_at AI854156 EST AA4087299683 0.67061 1.16 down Mm.6458 Timeless 100953_at AB015598 timeless homolog (Drosophila)9684 0.67070 1.19 down Mm.130961 Mm.130961 100828_at AI648850 ESTs, Moderately similar to MYOSIN LIGHT CHAIN 1, ATRIAL/FOETAL ISO9685 0.67087 1.30 down Mm.5180 Nr0b1 162413_r_at AV319285 nuclear receptor subfamily 0, group B, member 19686 0.67146 1.11 down Mm.1982 AI848108 103216_f_at AW122931 expressed sequence AI8481089687 0.67147 1.12 down Mm.28777 AI115446 94445_at AW125273 expressed sequence AI1154469688 0.67157 1.22 up Mm.21873 Ris2 94024_at AA671429 retroviral integration site 19689 0.67164 1.30 down Mm.24493 D3Wsu167e 94668_at AA408385 DNA segment, Chr 3, Wayne State University 167, expressed9690 0.67179 1.14 up Mm.2399 Lama4 104587_at U69176 laminin, alpha 49691 0.67183 1.26 up Mm.27839 4930455J02Rik 97239_at AI845106 RIKEN cDNA 4930455J02 gene9692 0.67196 1.35 up Mm.2446 Syt4 160190_at U10355 synaptotagmin 49693 0.67203 1.32 up Mm.6426 Tnfsf11 93416_at AF019048 tumor necrosis factor (ligand) superfamily, member 119694 0.67208 1.12 up Mm.22269 Xpo1 94228_at AW123788 exportin 1, CRM1 homolog (yeast)9695 0.67213 1.08 down Mm.3584 AA407621 98509_at AI834979 expressed sequence AA4076219696 0.67226 1.15 up Mm.21964 AU016842 94044_at AA692708 expressed sequence AU0168429697 0.67244 1.13 up Mm.28936 1810035L17Rik 96743_at AA958560 RIKEN cDNA 1810035L17 gene9698 0.67246 1.10 down Mm.25072 Trfp 162114_f_at AV367188 Trf (TATA binding protein-related factor)-proximal protein homolog (Drosoph9699 0.67247 1.19 up Mm.42015 Sema5b 97791_at X97818 sema domain, seven thrombospondin repeats (type 1 and type 1-like), transm9700 0.67250 1.26 up Mm.809 Jak2 96488_at AV246464 Janus kinase 29701 0.67262 1.22 down Mm.143686 Psg16 102694_at U34272 pregnancy specific glycoprotein 169702 0.67280 1.26 up Mm.5438 D7Ertd1e 101663_s_at C76227 DNA segment, Chr 7, ERATO Doi 1, expressed9703 0.67295 1.14 down Mm.6972 Ephb3 93469_at Z49086 Eph receptor B39704 0.67297 1.12 down Mm.28679 0610007P06Rik 98934_at AI847513 RIKEN cDNA 0610007P06 gene9705 0.67306 1.63 down Mm.30300 Ceacam10 161825_f_at AV381191 CEA-related cell adhesion molecule 109706 0.67313 1.25 up Mm.4533 Apoa4 100078_at M64248 apolipoprotein A-IV9707 0.67318 1.19 down Mm.1658 Flt3l 102929_s_at L23636 FMS-like tyrosine kinase 3 ligand9708 0.67329 1.33 up Mm.4630 Ptger2 98768_at AB007696 prostaglandin E receptor 2 (subtype EP2)9709 0.67342 1.24 up Mm.6128 Mm.6128 100929_at AW046351 ESTs9710 0.67350 1.14 up Mm.369 Abca1 97198_at X75926 ATP-binding cassette, sub-family A (ABC1), member 19711 0.67350 1.11 down Mm.3444 Brd2 98066_r_at AL009226 bromodomain-containing 29712 0.67351 1.13 up Mm.388 Ada 98632_at M10319 adenosine deaminase9713 0.67388 1.14 down Mm.28642 AI428936 161008_at AW125870 expressed sequence AI4289369714 0.67391 1.17 up Mm.3230 Scamp3 98015_at AF005036 secretory carrier membrane protein 39715 0.67423 1.22 down Mm.1287 Mapt 102431_at M18775 microtubule-associated protein tau9716 0.67426 1.22 up Mm.27334 Vnn3 104181_at AJ132103 vanin 39717 0.67437 1.28 up Mm.1353 Egr2 161531_r_at AV232606 early growth response 29718 0.67438 1.13 down Mm.45570 Acp2 92688_at X57199 acid phosphatase 2, lysosomal9719 0.67449 1.29 up Mm.14309 Hsd3b4 92869_at L16919 hydroxysteroid dehydrogenase-4, delta-3-beta9720 0.67455 1.14 up Mm.5027 Ezh1 100486_at U60453 enhancer of zeste homolog 1 (Drosophila)Page 108 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description9721 0.67478 1.09 down Mm.4428 Mm.4428 99975_at AA879937 Mus musculus, clone MGC:31389 IMAGE:4241819, mRNA, complete cds9722 0.67489 1.17 up Mm.22067 Tpra40-pending 104131_at AI842363 transmembrane domain protein regulated in adipocytes 40 kDa9723 0.67509 1.42 up Mm.21495 Mapk8 100391_at AB005663 mitogen activated protein kinase 89724 0.67551 1.23 up Mm.22045 Cypf13 162058_f_at AV271456 cytochrome P450 CYP4F139725 0.67556 1.20 up Mm.8201 Nck1 160932_at AF084183 non-catalytic region of tyrosine kinase adaptor protein 19726 0.67559 1.29 down Mm.219631 Mm.219631 93870_at M64429 Mouse B-raf oncogene mRNA, complete cds9727 0.67559 1.21 up Mm.40321 4631434O19Rik 161447_f_at AV355157 RIKEN cDNA 4631434O19 gene9728 0.67562 1.14 up Mm.32738 Mm.32738 97105_at AI642677 ESTs9729 0.67585 1.18 up Mm.27582 AA617265 160238_at AW045981 expressed sequence AA6172659730 0.67598 1.12 down Mm.25640 2700026H11Rik 161966_f_at AV369013 RIKEN cDNA 2700026H11 gene9731 0.67701 1.15 up Mm.14747 Ifitm3l 93018_at AI790103 interferon induced transmembrane protein 3-like9732 0.67717 1.18 down Mm.1361 Cga 162502_f_at AV173687 glycoprotein hormones, alpha subunit9733 0.67750 1.25 down Mm.212678 Mm.212678 161545_r_at AV242257 Mouse adult skeletal muscle myosin heavy chain mrna carboxyl-end, segme9734 0.67752 1.24 up Mm.27481 Akap12 95022_at AB020886 A kinase (PRKA) anchor protein (gravin) 129735 0.67754 1.35 up Mm.34947 C80892 97147_at C80892 expressed sequence C808929736 0.67759 1.10 down Mm.201803 AW125421 98356_at AW125421 expressed sequence AW1254219737 0.67770 1.18 up Mm.4438 Hmga1 100049_at J04179 high mobility group AT-hook 19738 0.67778 1.13 down Mm.27795 AA408420 161429_at AV305288 expressed sequence AA4084209739 0.67791 1.14 up Mm.195249 Timm44 98106_at U69898 translocator of inner mitochondrial membrane 449740 0.67795 1.10 down Mm.205937 2010004P11Rik 94898_at AI848555 RIKEN cDNA 2010004P11 gene9741 0.67821 1.23 up Mm.3007 Mm.3007 96576_at AI464718 ESTs9742 0.67838 1.29 up Mm.24134 D12Ertd364e 95894_at AW125034 DNA segment, Chr 12, ERATO Doi 364, expressed9743 0.67841 1.25 up Mm.200561 C79663 98247_at C79663 expressed sequence C796639744 0.67846 1.21 up Mm.2824 Entpd1 160774_at AF037366 ectonucleoside triphosphate diphosphohydrolase 19745 0.67850 1.25 up Mm.26644 1810055D05Rik 161663_f_at AV130375 RIKEN cDNA 1810055D05 gene9746 0.67855 1.08 down Mm.2065 Ctps2 160652_at U49385 cytidine 5'-triphosphate synthase 29747 0.67857 1.22 up Mm.4769 Fzd6 101142_at U43319 frizzled homolog 6 (Drosophila)9748 0.67882 1.26 down Mm.28369 Fbxo15 96162_at AA683807 f-box only protein 159749 0.67914 1.30 up Mm.21453 Mm.21453 104040_at AW045279 ESTs, Weakly similar to S44893 ZK1236.7 protein - Caenorhabditis elegans9750 0.67922 1.24 up Mm.5114 Dvl2 100495_at U24160 dishevelled 2, dsh homolog (Drosophila)9751 0.67925 1.14 down Mm.25581 5730406H10Rik 96014_at AI847863 RIKEN cDNA 5730406H10 gene9752 0.67939 1.22 up Mm.66204 Mm.66204 161543_at AV240479 EST9753 0.67945 1.11 down Mm.4341 Pvs 99934_at M80206 poliovirus sensitivity9754 0.67950 1.09 up Mm.205422 Mm.205422 103479_at AI593535 ESTs9755 0.67961 1.13 down Mm.7103 Pbx2 101345_at AF030001 pre B-cell leukemia transcription factor 29756 0.67962 1.08 down Mm.27213 Mm.27213 160225_at AI840450 Mus musculus, general transcription factor IIB, clone MGC:6859 IMAGE:2659757 0.67962 1.16 down Mm.502 Ifnar 100483_at M89641 interferon (alpha and beta) receptor9758 0.67967 1.05 down Mm.29405 Rbx1 95124_i_at AW122337 ring-box 19759 0.67972 1.11 up Mm.2206 Ndufv2 162327_f_at AV084684 NADH dehydrogenase (ubiquinone) flavoprotein 29760 0.67973 1.22 down Mm.55843 Ppp1r2 95680_at AI851984 protein phosphatase 1, regulatory (inhibitor) subunit 29761 0.67987 1.22 down Mm.22413 1110068L01Rik 104717_at AI848330 RIKEN cDNA 1110068L01 gene9762 0.67997 1.23 down Mm.1346 Itga4 102656_at X53177 integrin alpha 49763 0.68008 1.19 down Mm.1224 Cd3z 102287_at J04967 CD3 antigen, zeta polypeptide9764 0.68021 1.16 up Mm.43345 AI844545 92531_at AI844545 expressed sequence AI8445459765 0.68031 1.36 up Mm.2531 Cfc1 103945_at U57720 cripto, FRL-1, cryptic family 19766 0.68052 1.12 down Mm.4550 Atp1b1 161467_f_at AV348528 ATPase, Na+/K+ transporting, beta 1 polypeptide9767 0.68063 1.26 up 96966_at M302089768 0.68075 1.14 up Mm.14318 AI324046 102721_at D14625 expressed sequence AI3240469769 0.68097 1.29 up Mm.5168 Adam3 100526_f_at X64227 a disintegrin and metalloprotease domain 3 (cyri<strong>test</strong>in)9770 0.68108 1.20 up Mm.56920 Kcnj5 99376_at U33631 potassium inwardly-rectifying channel, subfamily J, member 59771 0.68121 1.17 up Mm.1008 Ptgds 92546_r_at AB006361 prostaglandin D2 synthase (21 kDa, brain)9772 0.68125 1.18 down Mm.5073 Sp4 92993_r_at AI324972 trans-acting transcription factor 49773 0.68169 1.29 up Mm.196638 Rab6kifl 103679_at AA940503 Rab6, kinesin-like9774 0.68191 1.33 up Mm.190436 2010012F05Rik 99473_at AI847622 RIKEN cDNA 2010012F05 gene9775 0.68193 1.27 up Mm.22765 5730508B09Rik 104515_at AI286818 RIKEN cDNA 5730508B09 gene9776 0.68199 1.09 down Mm.67837 Spph1-pending 94501_at AI835784 sphingosine-1-phosphate phosphatase 19777 0.68221 1.14 up Mm.30212 C76483 161464_f_at AV347226 EST C764839778 0.68231 1.13 up Mm.28365 4930529O08Rik 160289_s_at AI849904 RIKEN cDNA 4930529O08 gene9779 0.68233 1.15 down Mm.684 Ctsc 101019_at U74683 cathepsin C9780 0.68236 1.14 down Mm.1528 Gpc4 102886_at X83577 glypican 49781 0.68252 1.09 down Mm.200695 Tor2a 97557_at AI841457 torsin family 2, member A9782 0.68312 1.34 up 100361_f_at M302079783 0.68324 1.19 up Mm.73550 Stra13 93526_at U95004 stimulated by retinoic acid 139784 0.68324 1.18 down Mm.3555 Vdac1 98139_at U30840 voltage-dependent anion channel 19785 0.68326 1.08 up Mm.29183 Mrpl2 95067_at AI837821 mitochondrial ribosomal protein L29786 0.68327 1.12 down Mm.46624 2610028H07Rik 100115_at AW124128 RIKEN cDNA 2610028H07 gene9787 0.68343 1.12 up Mm.200634 Lef1 103628_at D16503 lymphoid enhancer binding factor 19788 0.68361 1.36 up Mm.5073 Sp4 92992_i_at AI324972 trans-acting transcription factor 49789 0.68367 1.29 up Mm.27087 2010012C24Rik 161283_i_at AV021443 RIKEN cDNA 2010012C24 gene9790 0.68384 1.11 down Mm.196580 Mm.196580 160165_at AI850365 Mus musculus, ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast),9791 0.68385 1.17 down Mm.1626 Tnfrsf6 102921_s_at M83649 tumor necrosis factor receptor superfamily, member 69792 0.68404 1.12 down Mm.314 AV011803 161016_at AA673574 expressed sequence AV0118039793 0.68405 1.30 up Mm.14438 AU044919 101276_at X55984 expressed sequence AU0449199794 0.68425 1.15 down Mm.196189 Angptl4 102114_f_at AI326963 angiopoietin-like 49795 0.68434 1.10 up Mm.23010 2810443J12Rik 99185_at AW047026 RIKEN cDNA 2810443J12 gene9796 0.68435 1.15 up Mm.12155 Stxbp3 92648_at U19521 syntaxin binding protein 39797 0.68448 1.26 down Mm.26595 Zfp275 161503_f_at AV124943 Zinc finger protein 2759798 0.68454 1.17 up Mm.22085 Arl3 104135_at AW045474 ADP-ribosylation-like 39799 0.68485 1.18 down Mm.12806 Ptafr 94158_f_at AF004858 platelet-activating factor receptor9800 0.68497 1.13 down Mm.27435 Boct-pending 95012_at AB012808 organic cation transporter9801 0.68509 1.07 up Mm.2287 Psma5 94841_at AW048997 proteasome (prosome, macropain) subunit, alpha type 59802 0.68513 1.19 down Mm.5438 D7Ertd1e 101218_at C76002 DNA segment, Chr 7, ERATO Doi 1, expressed9803 0.68534 1.23 up Mm.42080 Klk4 98288_at AF019979 kallikrein 4 (prostase, enamel matrix, prostate)9804 0.68538 1.09 down Mm.1318 Abl1 102772_at J02995 v-abl Abelson murine leukemia oncogene 19805 0.68549 1.37 up Mm.29350 Sdc2 162215_f_at AV380769 syndecan 29806 0.68550 1.18 down Mm.30029 Eef2k 104481_at U93848 eukaryotic elongation factor-2 kinase9807 0.68570 1.20 up Mm.20129 5730470C09Rik 103393_at AA738776 RIKEN cDNA 5730470C09 gene9808 0.68572 1.21 down Mm.20240 Ckmt2 103618_at AI181132 creatine kinase, mitochondrial 29809 0.68588 1.12 up Mm.29489 Mrpl34 160345_at AW125562 mitochondrial ribosomal protein L349810 0.68592 1.10 up Mm.27431 Traf3 95010_at U21050 Tnf receptor-associated factor 3Page 109 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description9811 0.68595 1.15 up Mm.4084 Ndst2 92400_at X75885 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 29812 0.68605 1.22 down Mm.849 Ppm1b 101836_at D45859 protein phosphatase 1B, magnesium dependent, beta isoform9813 0.68613 1.21 up Mm.200516 Pitpnb 102697_at U46934 phosphotidylinositol transfer protein, beta9814 0.68614 1.27 up Mm.46801 Mm.46801 102154_f_at M13284 M.musculus mRNA (2F7) for IgA V-D-J-heavy chain9815 0.68621 1.11 down Mm.22612 Mapkapk5 104364_at AF039840 MAP kinase-activated protein kinase 59816 0.68646 1.13 up Mm.28109 0610006H08Rik 97318_at AI846197 RIKEN cDNA 0610006H08 gene9817 0.68657 1.16 up Mm.29467 Rrad 97319_at AF084466 Ras-related associated with diabetes9818 0.68664 1.23 up Mm.2810 Chrng 161215_at AV248455 cholinergic receptor, nicotinic, gamma polypeptide9819 0.68675 1.19 up Mm.28110 Mm.28110 96326_at AI255353 Mus musculus, Similar to Tyrosine aminotransferase, clone MGC:37790 IMA9820 0.68698 1.19 down Mm.9478 Edn3 100766_at U32330 endothelin 39821 0.68712 1.15 up Mm.22345 2310046G15Rik 94238_at AW228316 RIKEN cDNA 2310046G15 gene9822 0.68733 1.14 down Mm.69 Nudc 101033_at Y15522 nuclear distribution gene C homolog (Aspergillus)9823 0.68737 1.20 up Mm.25054 Mm.25054 95991_at C79862 ESTs9824 0.68738 1.07 down Mm.18237 Dnajc1 103344_at L16953 DnaJ (Hsp40) homolog, subfamily C, member 19825 0.68740 1.17 down Mm.26564 AU019795 94439_at AW124363 expressed sequence AU0197959826 0.68740 1.07 up Mm.182412 Cdc16 96236_at AW122965 CDC16 (cell division cycle 16 homolog (S. cerevisiae)9827 0.68747 1.22 up Mm.3833 Rangap1 98603_s_at U20857 RAN GTPase activating protein 19828 0.68749 1.29 up Mm.1311 Mug1 92837_f_at M65736 murinoglobulin 19829 0.68751 1.17 up Mm.12818 Ddx4 94162_at D14859 DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 49830 0.68756 1.18 down Mm.27065 Chp-pending 96606_at AB025217 calcium binding protein P229831 0.68766 1.09 up Mm.29138 Chordc1 95050_at AW124547 cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein9832 0.68768 1.29 down Mm.39494 Mm.39494 92354_at AW122036 ESTs, Highly similar to MAF2 MOUSE TRANSCRIPTION FACTOR MAF2 [M9833 0.68771 1.11 up Mm.21974 Csk 94046_at U05247 c-src tyrosine kinase9834 0.68780 1.21 down Mm.3291 Flt4 104416_at L07296 FMS-like tyrosine kinase 49835 0.68784 1.14 down Mm.2547 Dad1 96008_at U81052 defender against cell death 19836 0.68825 1.19 down Mm.172523 Mm.172523 102110_at AA516748 EST9837 0.68831 1.37 down Mm.30169 Ehd1 96929_at AW122108 EH-domain containing 19838 0.68842 1.16 up Mm.23368 Acate2-pending 160171_f_at AI854821 acyl-Coenzyme A thioesterase 2, mitochondrial9839 0.68851 1.23 up Mm.560 Ly9 93194_at M84412 lymphocyte antigen 99840 0.68854 1.17 down Mm.4786 Inmp 101145_at U33198 intranuclear matrix protein9841 0.68867 1.28 up Mm.16519 Nr2f2 161792_f_at AV364118 nuclear receptor subfamily 2, group F, member 29842 0.68886 1.09 down Mm.218717 1810012I05Rik 99139_at AW123783 RIKEN cDNA 1810012I05 gene9843 0.68888 1.22 up Mm.16525 Plk 161292_f_at AV305987 polo-like kinase homolog, (Drosophila)9844 0.68904 1.18 down Mm.10082 Hip2 92548_g_at AB011081 huntingtin interacting protein 29845 0.68909 1.20 up Mm.22673 Fcer1g 162181_f_at AV012229 Fc receptor, IgE, high affinity I, gamma polypeptide9846 0.68914 1.19 up Mm.25142 5133400A03Rik 94345_at AI843709 RIKEN cDNA 5133400A03 gene9847 0.68936 1.07 down Mm.27607 Ranbp16 95526_at AI606243 RAN binding protein 169848 0.68940 1.12 down Mm.22176 4930506L07Rik 161199_at AV257523 RIKEN cDNA 4930506L07 gene9849 0.68963 1.19 up Mm.180868 Syt11 98339_at AB026808 synaptotagmin 119850 0.68968 1.08 down Mm.4717 AA589349 100428_at U43327 expressed sequence AA5893499851 0.68990 1.06 down Mm.28646 AI841135 96208_at AW123514 expressed sequence AI8411359852 0.69006 1.12 up Mm.6258 Eda 93395_g_at AF004435 ectodysplasin-A9853 0.69015 1.09 down Mm.3955 Eif3s7 99101_at AB012580 eukaryotic translation initiation factor 3, subunit 7 (zeta, 66/67 kDa)9854 0.69028 1.15 up Mm.3871 Ptdss2 160853_at AI840922 phosphatidylserine synthase 29855 0.69032 1.10 up Mm.200384 AA960621 160607_at AW123707 expressed sequence AA9606219856 0.69040 1.05 down Mm.195869 Atp6e 94532_at U13841 ATPase, H+ transporting lysosomal (vacuolar proton pump), 32 kDa9857 0.69041 1.36 up Mm.4179 Irf6 161699_i_at AV233700 interferon regulatory factor 69858 0.69045 1.31 down Mm.3644 Fabp7 98967_at U04827 fatty acid binding protein 7, brain9859 0.69055 1.15 down Mm.24100 AI115399 103711_at AI115399 expressed sequence AI1153999860 0.69058 1.31 up Mm.679 Rom1 93453_at M96760 rod outer segment membrane protein 19861 0.69073 1.19 down Mm.27799 1500011J06Rik 95568_at AI853412 RIKEN cDNA 1500011J06 gene9862 0.69080 1.10 up Mm.214981 Hist1 93023_f_at M32459 histone gene complex 19863 0.69109 1.06 up Mm.27927 Hnrpa1 92724_at AI183202 heterogeneous nuclear ribonucleoprotein A19864 0.69110 1.19 down Mm.2596 Mog 103987_at L20942 myelin oligodendrocyte glycoprotein9865 0.69115 1.28 up Mm.28986 Sqrdl 161733_at AV278406 sulfide quinone reductase-like (yeast)9866 0.69120 1.24 up Mm.14101 H1f4 99803_at Z46227 H1 histone family, member 49867 0.69122 1.12 up Mm.38674 Sytl4 96978_at AB025258 synaptotagmin-like 49868 0.69127 1.08 up Mm.4414 Cdc2l2 99961_s_at L37092 cell division cycle 2 homolog (S. pombe)-like 29869 0.69137 1.19 up Mm.23932 3110004L20Rik 160706_at AW123347 RIKEN cDNA 3110004L20 gene9870 0.69156 1.11 down Mm.27389 Vps41 96667_at AI851542 vacuolar protein sorting 41 (yeast)9871 0.69176 1.36 up Mm.16881 C79452 94783_at C79452 expressed sequence C794529872 0.69178 1.27 up Mm.2802 Mm.2802 96547_at AI661894 ESTs9873 0.69189 1.25 up Mm.28983 1110007M04Rik 161353_r_at AV156568 RIKEN cDNA 1110007M04 gene9874 0.69195 1.15 down Mm.46044 C79026 93464_at AI561567 expressed sequence C790269875 0.69200 1.14 down Mm.29343 Dtx2 96818_at AA762522 deltex 2 homolog (Drosophila)9876 0.69223 1.35 up Mm.541 Prm2 161229_at AV261930 protamine 29877 0.69234 1.22 down Mm.37216 Zhx1 161836_r_at AV326082 zinc fingers and homeoboxes protein 19878 0.69251 1.24 up Mm.195056 Fpr-rs1 95770_s_at AF071179 formyl peptide receptor, related sequence 19879 0.69257 1.46 down Mm.29415 1810011O01Rik 162473_r_at AV078636 RIKEN cDNA 1810011O01 gene9880 0.69265 1.26 up Mm.24458 D8Wsu26e 94657_at AA407378 DNA segment, Chr 8, Wayne State University 26, expressed9881 0.69268 1.18 down Mm.15780 Scya21b 103012_at AF035684 small inducible cytokine A21b (leucine)9882 0.69271 1.07 down Mm.28242 2810428I15Rik 160278_at AI854550 RIKEN cDNA 2810428I15 gene9883 0.69271 1.28 up Mm.29722 Usmg5 161452_f_at AV293047 upregulated during skeletal muscle growth 59884 0.69271 1.10 up Mm.36239 Mm.36239 101685_f_at AI463421 EST, Weakly similar to MKKS_MOUSE MCKUSICK-KAUFMAN/BARDET-BI9885 0.69282 1.10 down Mm.7515 Calu 161208_r_at AV245585 calumenin9886 0.69288 1.09 down Mm.1116 1700021P10Rik 102268_at AW123015 RIKEN cDNA 1700021P10 gene9887 0.69293 1.15 up Mm.1272 Rapsn 102300_at X15788 receptor-associated protein of the synapse, 43 kDa9888 0.69339 1.08 down Mm.16228 Slc25a4 93084_at U27315 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocato9889 0.69341 1.27 up Mm.24309 Mm.24309 162073_r_at AV326267 ESTs, Moderately similar to TSC1_RAT HAMARTIN (TUBEROUS SCLERO9890 0.69345 1.10 up Mm.203921 AI850305 94336_at AI838318 expressed sequence AI8503059891 0.69353 1.09 down Mm.3014 2310039H15Rik 96909_at AI849803 RIKEN cDNA 2310039H15 gene9892 0.69374 1.16 up Mm.198977 AI957187 104512_at AI957187 expressed sequence AI9571879893 0.69405 1.17 up Mm.5344 Mm.5344 101217_at D18865 ESTs9894 0.69409 1.14 down Mm.14487 Map2k6 102828_at U39066 mitogen activated protein kinase kinase 69895 0.69410 1.13 down Mm.154390 Fkbp5 94297_at U16959 FK506 binding protein 5 (51 kDa)9896 0.69415 1.36 down Mm.188701 Pou6f1 99891_at L13763 POU domain, class 6, transcription factor 19897 0.69425 1.24 down Mm.18494 Map2k3 93313_at X93150 mitogen activated protein kinase kinase 39898 0.69446 1.16 down Mm.98914 H2-Q1 92222_f_at U96752 histocompatibility 2, Q region locus 19899 0.69460 1.12 up Mm.5030 Gkap42-pending 160900_at AI847897 42 kD cGMP-dependent protein kinase anchoring protein9900 0.69465 1.21 up Mm.30346 Adk 101647_at U26589 adenosine kinasePage 110 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description9901 0.69521 1.24 up Mm.36421 Mm.36421 97189_at AA516843 ESTs9902 0.69527 1.14 down Mm.24356 9130427A09Rik 161885_f_at AV370153 RIKEN cDNA 9130427A09 gene9903 0.69532 1.14 up Mm.29098 AU015645 96790_f_at AW125222 expressed sequence AU0156459904 0.69563 1.17 up Mm.181847 Pfdn5 101513_at AI840454 prefoldin 59905 0.69569 1.27 up Mm.33951 Madh5 102865_at U58993 MAD homolog 5 (Drosophila)9906 0.69587 1.15 up Mm.42183 Cnot4 92495_at U71269 CCR4-NOT transcription complex, subunit 49907 0.69591 1.06 down Mm.21439 1110033E03Rik 103914_at AI847114 RIKEN cDNA 1110033E03 gene9908 0.69608 1.19 down 96977_at X162209909 0.69644 1.13 up Mm.788 Ly6e 101488_r_at U47737 lymphocyte antigen 6 complex, locus E9910 0.69661 1.07 down Mm.185247 Gys1 98496_at U53218 glycogen synthase 1, muscle9911 0.69673 1.13 down Mm.157743 Ddx6 101179_at D50494 DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 69912 0.69679 1.14 down Mm.21569 2700069E09Rik 161911_f_at AV121592 RIKEN cDNA 2700069E09 gene9913 0.69688 1.17 up Mm.5153 Ntsr2 93137_at U51908 neurotensin receptor 29914 0.69707 1.09 down Mm.495 1200006I17Rik 162481_f_at AV105090 RIKEN cDNA 1200006I17 gene9915 0.69715 1.36 up Mm.173304 Stx1b 101629_s_at D29743 syntaxin 1B9916 0.69725 1.27 up Mm.5218 Mm.5218 101202_at T25607 EST9917 0.69727 1.15 up Mm.3433 Ecm1 98054_at L33416 extracellular matrix protein 19918 0.69749 1.25 up Mm.35491 Mm.35491 98134_at AW048639 ESTs, Highly similar to KIAA0332 [H.sapiens]9919 0.69761 1.14 up Mm.22578 C78947 103511_at AI843580 expressed sequence C789479920 0.69767 1.12 down Mm.6529 Dm15 93431_at Z38015 dystrophia myotonica kinase, B159921 0.69772 1.15 down Mm.4126 Cct6b 92419_at AB022086 chaperonin subunit 6b (zeta)9922 0.69772 1.20 up Mm.13081 Sc5d 102769_f_at AB016248 sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevis9923 0.69812 1.30 up Mm.149115 Birc4 93401_g_at U88990 baculoviral IAP repeat-containing 49924 0.69812 1.17 down Mm.29145 D15Ertd806e 161927_at AV148893 DNA segment, Chr 15, ERATO Doi 806, expressed9925 0.69813 1.13 up Mm.35569 C77459 98489_at AI510131 EST C774599926 0.69846 1.16 up Mm.28696 AA409500 96218_at AW214322 expressed sequence AA4095009927 0.69855 1.10 down Mm.200540 R74921 102072_g_at AI851565 expressed sequence R749219928 0.69860 1.16 down Mm.18626 Capg 162461_at AV049046 capping protein (actin filament), gelsolin-like9929 0.69921 1.08 up Mm.1393 Ung 162227_r_at AV308861 uracil-DNA glycosylase9930 0.69933 1.14 down Mm.6150 Mm.6150 99830_at AI853573 ESTs, Highly similar to HAPP RAT HUNTINGTIN-ASSOCIATED PROTEIN-9931 0.69937 1.10 down Mm.183022 D8Bwg1112e 162057_f_at AV269118 DNA segment, Chr 8, Brigham & Women's Genetics 1112 expressed9932 0.69941 1.12 down Mm.28399 C80273 96174_at AW125692 expressed sequence C802739933 0.69946 1.10 down Mm.200862 AA589446 92241_at AI849075 expressed sequence AA5894469934 0.69966 1.15 up Mm.2252 1200008D14Rik 104338_r_at AW208938 RIKEN cDNA 1200008D14 gene9935 0.69975 1.08 up Mm.29088 0610013D04Rik 102343_at AF110520 RIKEN cDNA 0610013D04 gene9936 0.69983 1.26 up Mm.28904 D15Ertd781e 161807_i_at AV371503 DNA segment, Chr 15, ERATO Doi 781, expressed9937 0.69990 1.14 up Mm.3205 Scyd1 161752_r_at AV290053 small inducible cytokine subfamily D, 19938 0.70008 1.10 down Mm.156814 Mm.156814 99820_f_at AA204255 Mus musculus, Similar to cat eye syndrome chromosome region, candidate 59939 0.70009 1.25 up Mm.28362 AI326478 98974_at AI183084 expressed sequence AI3264789940 0.70047 1.23 up Mm.42165 Ssrzf1-pending 98310_at AB016984 spermatid specific RING zinc finger 19941 0.70062 1.17 down Mm.205520 Mm.205520 162286_r_at AV373294 Mus musculus, clone IMAGE:4988271, mRNA, partial cds9942 0.70090 1.07 up Mm.4441 Epb7.2 161176_r_at AV230593 erythrocyte protein band 7.29943 0.70109 1.25 up Mm.16422 AI256424 93096_at AA986050 expressed sequence AI2564249944 0.70116 1.10 down Mm.20894 Trp63 103810_at AB010152 transformation related protein 639945 0.70126 1.11 up Mm.19097 Pscd2 93492_at AB013469 pleckstrin homology, Sec7 and coiled/coil domains 29946 0.70133 1.17 up Mm.5012 Sh3bp2 92975_at L14543 SH3-domain binding protein 29947 0.70156 1.08 up Mm.30929 Prdx1 97055_s_at AI118194 peroxiredoxin 19948 0.70160 1.13 down Mm.1032 Hspa4 100353_g_at AA919208 heat shock 70 kDa protein 49949 0.70193 1.12 up Mm.22929 C77080 160697_at AW045507 expressed sequence C770809950 0.70193 1.28 down Mm.12971 Ugcg 94197_at D89866 UDP-glucose ceramide glucosyltransferase9951 0.70206 1.13 down Mm.12831 3830421F13Rik 102427_at AI849991 RIKEN cDNA 3830421F13 gene9952 0.70214 1.21 up Mm.28311 Mm.28311 161635_f_at AV008160 ESTs9953 0.70215 1.27 down Mm.14130 Dub1 100680_at U41636 deubiquitinating enzyme 19954 0.70233 1.26 up Mm.10169 Tpmt 102035_at AF037044 thiopurine methyltransferase9955 0.70235 1.21 up Mm.5040 Htr1f 101170_at Z14224 5-hydroxytryptamine (serotonin) receptor 1F9956 0.70238 1.15 down Mm.3238 Ampd3 104671_at D88994 AMP deaminase 39957 0.70239 1.35 up Mm.2024 Btc 95310_at L08394 betacellulin, epidermal growth factor family member9958 0.70252 1.29 up Mm.104295 Slc10a1 100341_g_at U95132 solute carrier family 10 (sodium/bile acid cotransporter family), member 19959 0.70267 1.32 up Mm.24436 Mm.24436 162126_r_at AV376442 ESTs9960 0.70268 1.04 down Mm.4948 1110048B16Rik 92958_at AI849135 RIKEN cDNA 1110048B16 gene9961 0.70279 1.06 down Mm.27130 Mm.27130 104163_at AA711002 Mus musculus, clone IMAGE:4952594, mRNA, partial cds9962 0.70302 1.11 down Mm.4540 Stip1 100081_at U27830 stress-induced phosphoprotein 19963 0.70310 1.22 up Mm.14455 Tgfbi 92877_at L19932 transforming growth factor, beta induced, 68 kDa9964 0.70319 1.12 down Mm.22306 1810045K06Rik 104293_at AI882440 RIKEN cDNA 1810045K06 gene9965 0.70346 1.15 up Mm.20399 Pfn2 93567_at AW122536 profilin 29966 0.70365 1.15 down Mm.3477 Elavl3 92239_at U29148 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)9967 0.70367 1.12 down Mm.18626 Capg 160106_at X54511 capping protein (actin filament), gelsolin-like9968 0.70369 1.06 down Mm.4609 Pex14 100027_s_at AI881987 peroxisomal biogenesis factor 149969 0.70373 1.08 up Mm.12706 Mm.12706 92804_at AW122864 Mus musculus, Similar to CG11246 gene product, clone MGC:8248 IMAGE:39970 0.70393 1.19 up Mm.62 Pde1b 93382_at AF023343 phosphodiesterase 1B, Ca2+-calmodulin dependent, 63 kDa9971 0.70411 1.14 down Mm.7124 2400004E04Rik 93481_at AI846720 RIKEN cDNA 2400004E04 gene9972 0.70444 1.16 down Mm.2564 Ap3s2 94388_at U91933 adaptor-related protein complex AP-3, sigma 2 subunit9973 0.70447 1.17 down Mm.21115 D5Ertd577e 103865_at AA589943 DNA segment, Chr 5, ERATO Doi 577, expressed9974 0.70454 1.17 up Mm.25007 Mm.25007 95878_at C79036 ESTs9975 0.70466 1.08 down Mm.11204 AA960392 92623_at AI847171 expressed sequence AA9603929976 0.70478 1.15 down Mm.79898 Mm.79898 92282_at AI646301 ESTs, Weakly similar to C02F5.4.p [Caenorhabditis elegans] [C.elegans]9977 0.70486 1.27 up Mm.4946 Ins2 100150_f_at X04724 insulin II9978 0.70486 1.12 up Mm.1806 AI481105 102965_at AW121646 expressed sequence AI4811059979 0.70518 1.09 down Mm.22467 Raf1 94264_at AW122170 v-raf-1 leukemia viral oncogene 19980 0.70527 1.11 down Mm.3386 Dtna 92183_at Z79787 dystrobrevin alpha9981 0.70530 1.06 up Mm.29076 2510010F10Rik 160326_at AI837005 RIKEN cDNA 2510010F10 gene9982 0.70535 1.22 down Mm.2822 Pecam 97830_at L06039 platelet/endothelial cell adhesion molecule9983 0.70554 1.16 down Mm.5011 Zfp37 161605_f_at AV345631 zinc finger protein 379984 0.70555 1.32 up Mm.3787 Svs6 162051_r_at AV380774 seminal vesicle secretion 69985 0.70562 1.22 down Mm.24040 Sftpc 94900_at AA921489 surfactant associated protein C9986 0.70580 1.14 down Mm.24254 Pdcd6 162490_f_at AV138382 programmed cell death 69987 0.70588 1.07 up Mm.2053 5830427H10Rik 93579_at AW121613 RIKEN cDNA 5830427H10 gene9988 0.70602 1.27 up Mm.24400 2010003F10Rik 104707_at AA718076 RIKEN cDNA 2010003F10 gene9989 0.70621 1.14 up Mm.13866 Madcam1 102679_at D50434 mucosal vascular addressin cell adhesion molecule 19990 0.70627 1.22 up Mm.154570 Erp29 161755_at AV292321 endoplasmic reticulum protein 29Page 111 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description9991 0.70629 1.09 up Mm.22749 BC005537 94830_at AI854300 hypothetical protein MGC74749992 0.70633 1.20 down Mm.10687 Brs3 94116_at AB010280 bombesin-like receptor 39993 0.70647 1.14 up Mm.232 AW488865 161909_r_at AV115502 expressed sequence AW4888659994 0.70662 1.12 down Mm.3256 Ap3m1 97526_at AW123294 adaptor-related protein complex AP-3, mu 1 subunit9995 0.70673 1.25 up Mm.14781 Cyp2a4 102847_s_at M19319 cytochrome P450, 2a49996 0.70673 1.09 down Mm.200843 Sncb 100510_at AI839708 synuclein, beta9997 0.70678 1.11 up Mm.2028 Ncoa1 103229_at U64828 nuclear receptor coactivator 19998 0.70689 1.11 up Mm.28010 C85201 160259_at AA647449 expressed sequence C852019999 0.70691 1.14 up Mm.2644 AI415009 161738_f_at AV314618 expressed sequence AI41500910000 0.70711 1.18 down Mm.28256 Narg1-pending 93246_at AW260482 NMDA receptor-regulated gene 110001 0.70716 1.22 up Mm.20832 Robo1 103675_at Y17793 roundabout homolog 1 (Drosophila)10002 0.70735 1.06 down Mm.12758 Fkbp4 92808_f_at X17069 FK506 binding protein 4 (59 kDa)10003 0.70754 1.33 up 103003_i_at U5761110004 0.70756 1.26 down Mm.1889 Brca1 102976_at U32446 breast cancer 110005 0.70793 1.09 up Mm.12539 AW214405 102409_at AW046963 expressed sequence AW21440510006 0.70794 1.15 up Mm.22357 T25636 94243_at AI849588 expressed sequence T2563610007 0.70798 1.16 down Mm.3507 Nr4a2 92249_g_at U86783 nuclear receptor subfamily 4, group A, member 210008 0.70798 1.08 up Mm.176233 Mm.176233 161122_f_at AV032952 ESTs10009 0.70801 1.21 down Mm.46316 Serpinb1a 100100_at AA762212 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1a10010 0.70806 1.22 up Mm.17799 Lgals8 160618_at AA760613 lectin, galactose binding, soluble 810011 0.70807 1.18 up Mm.4345 Tie1 99936_at X80764 tyrosine kinase receptor 110012 0.70811 1.06 down Mm.153372 Brap 160113_at AI854472 BRCA1 associated protein10013 0.70815 1.27 up Mm.21228 C79684 103313_r_at AW047929 expressed sequence C7968410014 0.70834 1.10 down Mm.28159 Pmscl2 96136_at AI553452 polymyositis/scleroderma autoantigen 210015 0.70835 1.11 down Mm.29515 D14Ertd813e 97325_at AA881294 DNA segment, Chr 14, ERATO Doi 813, expressed10016 0.70844 1.19 down Mm.9488 Clk4 101937_s_at AF005423 CDC like kinase 410017 0.70845 1.27 down Mm.44848 5730437E04Rik 97101_at AI640003 RIKEN cDNA 5730437E04 gene10018 0.70853 1.27 up Mm.14115 Ets1 94332_at AI882555 E26 avian leukemia oncogene 1, 5' domain10019 0.70858 1.09 up Mm.133467 D4Wsu124e 95355_at AA407794 DNA segment, Chr 4, Wayne State University 124, expressed10020 0.70879 1.26 up Mm.3999 Mpeg1 162075_r_at AV281445 macrophage expressed gene 110021 0.70882 1.37 up Mm.10726 Stag3 160943_at AJ005678 stromal antigen 310022 0.70901 1.12 down Mm.9334 Prkar1b 94944_at AW125016 protein kinase, cAMP dependent regulatory, type I beta10023 0.70904 1.18 up Mm.3888 Mm.3888 92328_at L36135 Mouse (clone RAD11) T-cell receptor rearranged delta-chain mRNA V-D-J-C10024 0.70913 1.11 up Mm.153911 Pls2 94278_at D37837 plastin 2, L10025 0.70915 1.20 down Mm.20253 Mtmr7 103228_at AF073882 myotubularin related protein 710026 0.70915 1.04 up Mm.4069 Atp5a1 100753_at L01062 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, iso10027 0.70948 1.14 down Mm.23845 1600017K21Rik 162365_i_at AV231477 RIKEN cDNA 1600017K21 gene10028 0.70958 1.17 down Mm.2777 Tpd52 162463_at AV059497 tumor protein D5210029 0.70985 1.09 up Mm.27128 2310074H19Rik 96617_at AI844737 RIKEN cDNA 2310074H19 gene10030 0.70992 1.10 down Mm.42855 1110030G05Rik 99600_at AI838337 RIKEN cDNA 1110030G05 gene10031 0.71002 1.16 up Mm.465 Sdf1 162234_f_at AV139913 stromal cell derived factor 110032 0.71009 1.12 up Mm.20437 Dnajb5 102620_at AF088983 DnaJ (Hsp40) homolog, subfamily B, member 510033 0.71036 1.23 down Mm.4571 Chi3l3 92694_at M94584 chitinase 3-like 310034 0.71043 1.20 up Mm.57070 Ptch 104031_at U46155 patched homolog10035 0.71046 1.19 up Mm.27341 Mm.27341 161270_i_at AV319920 ESTs, Highly similar to AF227741 1 protein kinase WNK1 [R.norvegicus]10036 0.71060 1.16 up Mm.8321 Cit 93687_r_at U39904 citron10037 0.71066 1.07 down Mm.8983 Tnfsf12 93917_at AF030100 tumor necrosis factor (ligand) superfamily, member 1210038 0.71092 1.15 up Mm.1122 Alox12-ps2 102269_at U24181 arachidonate 12-lipoxygenase, pseudogene 210039 0.71095 1.12 up Mm.28374 Mm.28374 102966_at AA934166 Mus musculus, clone MGC:29037 IMAGE:3598248, mRNA, complete cds10040 0.71105 1.06 up Mm.39061 Adss2 99038_at L24554 adenylosuccinate synthetase 2, non muscle10041 0.71109 1.12 up Mm.39292 Dnm2 161726_f_at AV266884 dynamin 210042 0.71117 1.11 down Mm.28507 5530401C11Rik 160785_at AI155273 RIKEN cDNA 5530401C11 gene10043 0.71129 1.18 up Mm.46749 AI643885 100417_at AI643885 expressed sequence AI64388510044 0.71138 1.10 up Mm.13036 Cml1 92835_at AI840501 camello-like 110045 0.71155 1.11 up Mm.6357 Sos1 160911_at Z11574 Son of sevenless homolog 1, (Drosophila)10046 0.71157 1.33 down Mm.7719 Bmi1 161375_at AV242863 B lymphoma Mo-MLV insertion region 110047 0.71164 1.41 up Mm.68712 Fzd4 95771_i_at U43317 frizzled homolog 4 (Drosophila)10048 0.71174 1.20 down Mm.4605 Tbx2 104655_at AA755817 T-box 210049 0.71183 1.24 down Mm.194940 AI194696 92291_f_at M29008 expressed sequence AI19469610050 0.71188 1.19 down Mm.8071 Taa1 94643_at U35836 tumor-associated antigen 110051 0.71192 1.20 down Mm.16773 Alb1 94777_at X13060 albumin 110052 0.71201 1.16 up Mm.57033 Mm.57033 96975_at X82691 M.musculus immunoglobulin kappa chain variable region10053 0.71210 1.26 up Mm.143833 Klk21 162456_f_at AV046312 kallikrein 2110054 0.71217 1.20 down Mm.14287 Hspa1l 100946_at AF109906 heat shock 70kD protein 1-like10055 0.71222 1.10 up Mm.142187 2610009E16Rik 95723_r_at AI841464 RIKEN cDNA 2610009E16 gene10056 0.71242 1.23 up Mm.18625 Aqp1 161559_i_at AV315635 aquaporin 110057 0.71272 1.15 down Mm.195966 Prlr-rs1 93926_at M22957 prolactin receptor related sequence 110058 0.71288 1.34 up Mm.4685 Flg 161981_r_at AV230893 filaggrin10059 0.71290 1.26 up Mm.34637 Catna2 161318_f_at AV353749 catenin alpha 210060 0.71306 1.23 up Mm.39884 Ramp3 92368_at AJ250491 receptor (calcitonin) activity modifying protein 310061 0.71330 1.14 up Mm.34453 Mrps2 160423_at AI853575 mitochondrial ribosomal protein S210062 0.71331 1.23 up Mm.24939 Mm.24939 95959_at C76966 ESTs10063 0.71339 1.18 up Mm.4435 Snap25 100047_at M22012 synaptosomal-associated protein, 25 kDa10064 0.71351 1.23 up Mm.30087 G6pt1 97430_at AF080469 glucose-6-phosphatase, transport protein 110065 0.71372 1.21 up Mm.4306 Terf1 99920_at U65586 telomeric repeat binding factor 110066 0.71373 1.22 up Mm.4710 Mrg2 92753_at U57344 myeloid ecotropic viral integration site-related gene 210067 0.71391 1.25 down Mm.19423 Cdh16 93515_at AF016271 cadherin 1610068 0.71399 1.25 down Mm.1378 Cnr2 102674_at X86405 cannabinoid receptor 2 (macrophage)10069 0.71402 1.20 up Mm.40068 Tubb3 161612_f_at AV350617 tubulin, beta 310070 0.71405 1.17 down Mm.22261 Net1 94223_at AJ010045 neuroepithelial cell transforming gene 110071 0.71407 1.13 down Mm.22438 Ssbp2 103504_at AI837107 single-stranded DNA binding protein 210072 0.71420 1.13 down Mm.4720 Gpcr12 98784_at D21061 G-protein coupled receptor 1210073 0.71450 1.14 down Mm.28192 Pcm1 96140_at AF039021 pericentriolar material 110074 0.71455 1.07 up Mm.3363 Psap 161476_at AV011715 prosaposin10075 0.71472 1.25 down Mm.37213 Ptprb 92289_at X58289 protein tyrosine phosphatase, receptor type, B10076 0.71473 1.11 up Mm.66489 D14Ertd114e 160783_at AW123154 DNA segment, Chr 14, ERATO Doi 114, expressed10077 0.71479 1.11 down Mm.21908 Bach2 160148_at D86604 BTB and CNC homology 210078 0.71491 1.10 down Mm.2444 Myc 104712_at L00039 myelocytomatosis oncogene10079 0.71510 1.12 down Mm.196449 Rnp24-pending 93817_at AB025218 coated vesicle membrane protein10080 0.71581 1.15 up Mm.29915 Mm.29915 160368_at AI836707 Mus musculus, clone MGC:36924 IMAGE:4945988, mRNA, complete cdsPage 112 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description10081 0.71612 1.21 up Mm.3667 Vtn 98549_at M77123 vitronectin10082 0.71612 1.12 down Mm.29511 Mm.29511 97324_at AW048291 Mus musculus, clone MGC:25845 IMAGE:4192995, mRNA, complete cds10083 0.71612 1.11 down Mm.17392 Bfzb-pending 103090_at AI838742 basic FGF repressed, Zic binding protein10084 0.71630 1.14 up Mm.5162 4432411H13Rik 93139_at AI504310 RIKEN cDNA 4432411H13 gene10085 0.71644 1.12 down Mm.10407 Nicn1 102059_at AW125418 nicolin 110086 0.71678 1.17 up Mm.5545 2410001M24Rik 161507_f_at AV141464 RIKEN cDNA 2410001M24 gene10087 0.71696 1.36 up Mm.16781 Aeg1 93122_at M92849 acidic epididymal glycoprotein 110088 0.71706 1.14 up Mm.5275 AW045600 93158_at AW048311 expressed sequence AW04560010089 0.71716 1.26 down Mm.4930 Slc29a2 92950_at X86682 solute carrier family 29 (nucleoside transporters), member 210090 0.71716 1.26 down Mm.26237 Cry1 161225_r_at AV273959 cryptochrome 1 (photolyase-like)10091 0.71717 1.10 down Mm.142263 Rce1 96838_at AI851223 Ras and a-factor-converting enzyme 1 homolog (S. cerevisiae)10092 0.71748 1.13 up Mm.29073 C330026P08Rik 160324_at AI848299 RIKEN cDNA C330026P08 gene10093 0.71749 1.08 down Mm.149 Rad52 102878_at U12135 RAD52 homolog, (S. cerevisiae)10094 0.71753 1.17 up Mm.148278 Map4k1 104688_at Y09010 mitogen activated protein kinase kinase kinase kinase 110095 0.71760 1.27 up Mm.24544 Mm.24544 95182_at AA420381 EST10096 0.71769 1.18 up Mm.3409 AI462269 98421_at AI835126 expressed sequence AI46226910097 0.71776 1.13 up Mm.10229 Nssr 98048_at AF060490 neural-salient serine/arginine-rich10098 0.71804 1.20 up Mm.41576 Kif5c 92433_at AF067180 kinesin family member 5C10099 0.71809 1.22 up Mm.14101 H1f4 95388_at Z38128 H1 histone family, member 410100 0.71823 1.20 up Mm.193452 Insl3 101873_at X95603 insulin-like 310101 0.71837 1.06 up Mm.7013 0610038L10Rik 101050_at AF031381 RIKEN cDNA 0610038L10 gene10102 0.71860 1.06 up Mm.29990 1700006C06Rik 96342_at AI846320 RIKEN cDNA 1700006C06 gene10103 0.71861 1.10 down Mm.2060 2900010I05Rik 93581_at AI845121 RIKEN cDNA 2900010I05 gene10104 0.71875 1.31 up Mm.1438 Kcnab1 102725_at AF033003 potassium voltage-gated channel, shaker-related subfamily, beta member 110105 0.71883 1.18 up Mm.7244 Agr2 101076_r_at AB016592 anterior gradient 2 (Xenopus laevis)10106 0.71907 1.04 up Mm.181009 0610013I17Rik 160396_at AW121580 RIKEN cDNA 0610013I17 gene10107 0.71931 1.09 up Mm.9257 D10Wsu52e 101960_at AI842208 DNA segment, Chr 10, Wayne State University 52, expressed10108 0.71940 1.16 up Mm.104747 Igk-V28 93213_at AB007986 immunoglobulin kappa chain variable 28 (V28)10109 0.71942 1.26 up Mm.22284 1110023P21Rik 160154_at AI846493 RIKEN cDNA 1110023P21 gene10110 0.71953 1.22 down Mm.26304 AU022220 161445_at AV353631 expressed sequence AU02222010111 0.71980 1.11 down Mm.219554 Pcdha13 101771_r_at AB008180 protocadherin alpha 1310112 0.71981 1.13 up Mm.24863 1700021F05Rik 103780_at AW049510 RIKEN cDNA 1700021F05 gene10113 0.72007 1.24 down Mm.57124 Hoxd12 99427_at X58849 homeo box D1210114 0.72015 1.12 up Mm.24542 1110013E13Rik 104722_at AW121342 RIKEN cDNA 1110013E13 gene10115 0.72019 1.21 up Mm.392 Indo 97731_at M69109 indoleamine-pyrrole 2,3 dioxygenase10116 0.72062 1.10 down Mm.22722 Raly 98511_at L17076 hnRNP-associated with lethal yellow10117 0.72064 1.06 down Mm.12145 Rbbp4 92647_at U35141 retinoblastoma binding protein 410118 0.72071 1.27 up 100388_at L3421610119 0.72086 1.19 up Mm.181881 2610003J06Rik 94520_at AW227576 RIKEN cDNA 2610003J06 gene10120 0.72100 1.23 up Mm.3421 Fin15 97124_at U42384 fibroblast growth factor inducible 1510121 0.72107 1.11 up Mm.42090 Cded 98290_at AF027185 cell differentiation and embryonic development10122 0.72117 1.23 up Mm.5816 C79296 101604_at C79296 expressed sequence C7929610123 0.72123 1.13 down Mm.180337 3110002K08Rik 97310_at AW124318 RIKEN cDNA 3110002K08 gene10124 0.72143 1.18 up Mm.29201 Gbe1 96803_at AW210370 glucan (1,4-alpha-), branching enzyme 110125 0.72170 1.07 up Mm.142105 1200003O06Rik 94548_at AI790537 RIKEN cDNA 1200003O06 gene10126 0.72187 1.26 down Mm.24535 AA415014 161106_r_at AA415014 expressed sequence AA41501410127 0.72190 1.21 up Mm.3953 Hmga2 99058_at X99915 high mobility group AT-hook 210128 0.72192 1.18 up Mm.4369 Adrb3 92538_at X72862 adrenergic receptor, beta 310129 0.72210 1.22 up Mm.29254 Igfbp3 95083_at X81581 insulin-like growth factor binding protein 310130 0.72213 1.14 up Mm.44214 2510010F15Rik 160491_at AW125589 RIKEN cDNA 2510010F15 gene10131 0.72220 1.11 up Mm.27523 1500031J01Rik 96692_at AA759408 RIKEN cDNA 1500031J01 gene10132 0.72228 1.27 up Mm.5159 Apbb2 161163_at AV233586 amyloid beta (A4) precursor protein-binding, family B, member 210133 0.72229 1.24 up Mm.24612 Bst1 103759_at D31788 bone marrow stromal cell antigen 110134 0.72248 1.11 down Mm.6952 Kpna1 101370_at U20619 karyopherin (importin) alpha 110135 0.72267 1.10 up Mm.4835 Htr5a 101152_at Z18278 5-hydroxytryptamine (serotonin) receptor 5A10136 0.72268 1.12 down Mm.22358 1500004O14Rik 104303_i_at AW124151 RIKEN cDNA 1500004O14 gene10137 0.72269 1.33 up Mm.932 Mm.932 161233_at AV277865 Mus musculus DNA segment, Chr X, Celltech Chiroscience 3 (DXCch3), mR10138 0.72270 1.17 up Mm.14190 Il2 102705_at K02292 interleukin 210139 0.72279 1.07 up Mm.3856 Tmk 98619_at AW121709 thymidylate kinase10140 0.72282 1.17 up Mm.21961 Atp6s1 161806_r_at AV353754 ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 110141 0.72283 1.25 down Mm.10085 Nfatc1 102209_at AF087434 nuclear factor of activated T-cells, cytoplasmic 110142 0.72307 1.25 up Mm.5151 Lhx5 101192_at U61155 LIM homeobox protein 510143 0.72309 1.24 up Mm.5750 2310032K15Rik 162389_at AV258250 RIKEN cDNA 2310032K15 gene10144 0.72311 1.14 up Mm.29170 Fbxw5 96799_at AA822413 f-box and WD-40 domain protein 510145 0.72329 1.11 up Mm.21407 R74819 93799_at AI845933 expressed sequence R7481910146 0.72352 1.21 up Mm.87594 Ches1 104664_at AA725931 checkpoint suppressor 110147 0.72357 1.09 up Mm.85892 1110020A23Rik 95634_at AI848107 RIKEN cDNA 1110020A23 gene10148 0.72415 1.11 down Mm.196596 2400010D15Rik 160433_at AF003352 RIKEN cDNA 2400010D15 gene10149 0.72433 1.10 down Mm.16553 Nedd4a 162172_f_at AV365271 neural precursor cell expressed, developmentally down-regulated gene 4a10150 0.72439 1.15 up Mm.2136 Cox4a 93788_at M37831 cytochrome c oxidase, subunit IVa10151 0.72451 1.22 down Mm.13854 Eya1 94705_at U61110 eyes absent 1 homolog (Drosophila)10152 0.72457 1.12 up Mm.28910 Cnot8 94490_at AW122419 CCR4-NOT transcription complex, subunit 810153 0.72457 1.10 up Mm.200975 Serf2 160563_at AI848801 small EDRK-rich factor 210154 0.72461 1.25 down Mm.14092 Foxc2 162016_f_at AV251191 forkhead box C210155 0.72475 1.26 up Mm.57153 Soat2 99431_at AF078751 sterol O-acyltransferase 210156 0.72491 1.21 down Mm.46724 Pvrl3 99062_at AI891912 poliovirus receptor-related 310157 0.72492 1.11 up Mm.4638 Gcap8 101134_at L10908 granule cell antiserum positive 810158 0.72496 1.07 up Mm.203516 AW060991 100900_at AW209053 expressed sequence AW06099110159 0.72497 1.07 down Mm.144286 1500034J20Rik 96068_at AI848821 RIKEN cDNA 1500034J20 gene10160 0.72538 1.12 up Mm.2632 Lxn 96065_at D88769 latexin10161 0.72551 1.08 up Mm.21495 Mapk8 104047_at AW122136 mitogen activated protein kinase 810162 0.72556 1.12 down Mm.6493 D11Ertd9e 93427_at AW122310 DNA segment, Chr 11, ERATO Doi 9, expressed10163 0.72556 1.09 up Mm.26782 Zfp99 104010_at U62906 zinc finger protein 9910164 0.72568 1.10 up Mm.179304 Ubc6p-pending 93525_f_at AI839376 ubiquitin conjugating enzyme 610165 0.72590 1.14 down Mm.25642 2310034K10Rik 94389_at AA915720 RIKEN cDNA 2310034K10 gene10166 0.72592 1.13 up Mm.5057 Mpa2 160523_at M81128 macrophage activation 210167 0.72595 1.17 up Mm.1321 Sftpd 102648_at L40156 surfactant associated protein D10168 0.72601 1.21 up Mm.29586 Basp1 95673_s_at AW124113 brain abundant, membrane attached signal protein 110169 0.72621 1.16 up Mm.1976 Cdh15 161366_r_at AV232449 cadherin 1510170 0.72628 1.13 up Mm.99113 Etl1 98991_at X69942 enhancer trap locus 1Page 113 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description10171 0.72637 1.11 down Mm.42078 Dpp6 98287_at AF092507 dipeptidylpeptidase 610172 0.72653 1.16 down Mm.143737 Ankrd2 97786_at AJ011118 ankyrin repeat domain 2 (stretch responsive muscle)10173 0.72653 1.07 down Mm.25285 1190005L05Rik 94365_at AA710175 RIKEN cDNA 1190005L05 gene10174 0.72672 1.11 up Mm.86933 2900008M13Rik 101856_at AI836771 RIKEN cDNA 2900008M13 gene10175 0.72682 1.45 down Mm.66 Rps4x 161654_r_at AV098925 ribosomal protein S4, X-linked10176 0.72688 1.13 down Mm.21078 2310057G13Rik 160659_at AI853129 RIKEN cDNA 2310057G13 gene10177 0.72690 1.20 up Mm.41987 Phxr1 101705_at X12809 per-hexamer repeat gene 110178 0.72691 1.14 down Mm.141187 Tgoln2 93882_f_at D50032 trans-golgi network protein 210179 0.72702 1.17 up Mm.8709 Srpk2 101857_at AB006036 serine/arginine-rich protein specific kinase 210180 0.72721 1.12 down Mm.2799 Mm.2799 161004_at AA250414 ESTs10181 0.72728 1.07 down Mm.1017 Es10 92553_at AB025408 esterase 1010182 0.72729 1.10 up Mm.1558 4921518A06Rik 102895_at AI153246 RIKEN cDNA 4921518A06 gene10183 0.72740 1.29 up Mm.29800 Cdc25a 97389_at U27323 cell division cycle 25 homolog A (S. cerevisiae)10184 0.72762 1.19 down Mm.219631 Mm.219631 161718_at AV254466 Mouse B-raf oncogene mRNA, complete cds10185 0.72769 1.20 up Mm.79898 Mm.79898 161532_f_at AV233237 ESTs, Weakly similar to C02F5.4.p [Caenorhabditis elegans] [C.elegans]10186 0.72806 1.14 down Mm.87820 Sprr2d 95793_at AJ005562 small proline-rich protein 2D10187 0.72811 1.08 up Mm.27795 AA408420 96541_at AI838636 expressed sequence AA40842010188 0.72840 1.15 up Mm.41580 Rab3b 160868_at AI835990 RAB3B, member RAS oncogene family10189 0.72844 1.21 up Mm.2050 2510008H07Rik 93578_at AI850794 RIKEN cDNA 2510008H07 gene10190 0.72863 1.20 up Mm.29150 2310075M16Rik 95056_r_at AW122747 RIKEN cDNA 2310075M16 gene10191 0.72879 1.08 up Mm.29468 6720463E02Rik 161960_f_at AV221845 RIKEN cDNA 6720463E02 gene10192 0.72879 1.09 down Mm.20925 Gspt1 93727_at AB003502 G1 to phase transition 110193 0.72882 1.27 down Mm.4776 Acrv1 92897_at U31992 acrosomal vesicle protein 110194 0.72900 1.11 down Mm.96867 AU022812 101939_at AI849344 expressed sequence AU02281210195 0.72902 1.21 down Mm.42368 4921513E08Rik 161577_f_at AV284166 RIKEN cDNA 4921513E08 gene10196 0.72911 1.14 down Mm.10297 1300003D03Rik 102052_at AA871791 RIKEN cDNA 1300003D03 gene10197 0.72914 1.11 up Mm.21535 Grpel1 104057_at AW012807 GrpE-like 1, mitochondrial10198 0.72919 1.23 up Mm.14573 H2-T24 94746_at L22338 histocompatibility 2, T region locus 2410199 0.72928 1.11 up Mm.41679 Stk23 92436_at AF043288 serine/threonine kinase 2310200 0.72954 1.11 up Mm.196551 3110052D19Rik 104415_at AA833293 RIKEN cDNA 3110052D19 gene10201 0.72957 1.12 down Mm.6696 Rdh7 100634_at AF056194 retinol dehydrogenase 710202 0.72978 1.07 up Mm.101274 2010008E23Rik 93923_at AW259620 RIKEN cDNA 2010008E23 gene10203 0.72992 1.10 down Mm.218574 6330416C07Rik 162387_f_at AV255723 RIKEN cDNA 6330416C07 gene10204 0.72997 1.11 up Mm.36241 Bcap37 162501_at AV172042 B-cell receptor-associated protein 3710205 0.73010 1.08 down Mm.28664 1110018B13Rik 98929_at AI846452 RIKEN cDNA 1110018B13 gene10206 0.73013 1.14 down Mm.44245 Adcyap1r1 98361_at D82935 adenylate cyclase activating polypeptide 1 receptor 110207 0.73017 1.14 up Mm.182551 C77608 96552_at AA437717 expressed sequence C7760810208 0.73026 1.11 up Mm.38869 Pias1 99029_at AF077950 protein inhibitor of activated STAT 110209 0.73051 1.25 up Mm.17910 Hsd3b5 94795_at L41519 hydroxysteroid dehydrogenase-5, delta-3-beta10210 0.73053 1.19 down Mm.2015 Rab33a 103224_at D83277 RAB33A, member of RAS oncogene family10211 0.73056 1.12 down Mm.219644 Arhn 104432_at AF016482 ras homolog N (RhoN)10212 0.73056 1.18 down Mm.3521 Cckar 92252_at D85605 cholecystokinin A receptor10213 0.73058 1.14 down Mm.29744 Slc29a1 161687_r_at AV217246 solute carrier family 29 (nucleoside transporters), member 110214 0.73062 1.22 up Mm.6227 Gabrr2 99839_at AF024621 gamma-aminobutyric acid (GABA-A) receptor, subunit rho 210215 0.73069 1.17 up Mm.157893 Mup1 102096_f_at AI255271 major urinary protein 110216 0.73073 1.24 down Mm.141187 Tgoln2 93881_i_at D50032 trans-golgi network protein 210217 0.73080 1.23 up Mm.42062 Mm.42062 99198_at K02060 EST10218 0.73080 1.22 up Mm.24992 C78444 95972_at C78446 expressed sequence C7844410219 0.73094 1.17 down Mm.3434 Surf5 161561_r_at AV264321 surfeit gene 510220 0.73102 1.13 up Mm.3789 Plxn1 97699_at D86948 plexin 110221 0.73120 1.18 down Mm.21695 C81488 160673_at AI596544 expressed sequence C8148810222 0.73128 1.13 down Mm.16775 Rps24 93121_at X60289 ribosomal protein S2410223 0.73158 1.19 up Mm.30095 4930527D15Rik 104485_at AI552398 RIKEN cDNA 4930527D15 gene10224 0.73161 1.19 up Mm.26833 AW047992 161413_f_at AV315972 expressed sequence AW04799210225 0.73168 1.03 down Mm.3250 Drg1 98020_at D10715 developmentally regulated GTP binding protein 110226 0.73209 1.08 down Mm.594 Slc22a1 100916_at U38652 solute carrier family 22 (organic cation transporter), member 110227 0.73218 1.10 up Mm.29028 Dap3 94524_at AW123469 death associated protein 310228 0.73227 1.06 down Mm.29897 Mm.29897 96292_r_at AI835847 ESTs, Highly similar to NUMM MOUSE NADH-UBIQUINONE OXIDOREDUC10229 0.73245 1.17 up Mm.76983 M6a-pending 160929_at AA867235 m6a methyltransferase10230 0.73248 1.19 up Mm.27934 Arih2 95600_at AJ130975 ariadne homolog 2 (Drosophila)10231 0.73288 1.09 down Mm.336 2-Sep 97543_at D49382 septin 210232 0.73296 1.10 down Mm.138512 Mm.138512 103879_at AA914905 Mus musculus, Similar to hypothetical protein, clone MGC:38853 IMAGE:53610233 0.73323 1.20 up Mm.33622 2310040C09Rik 104695_at AI639864 RIKEN cDNA 2310040C09 gene10234 0.73345 1.16 down Mm.31140 C80993 97084_at C80993 expressed sequence C8099310235 0.73356 1.14 up Mm.21835 1810010M01Rik 160145_at AI593999 RIKEN cDNA 1810010M01 gene10236 0.73375 1.21 down Mm.5934 Ard1 161589_at AV324817 N-acetyltransferase ARD1 homolog (S. cerevisiae)10237 0.73384 1.19 up Mm.1359 Plaur 102663_at X62700 urokinase plasminogen activator receptor10238 0.73409 1.22 down Mm.946 D17Ertd315e 161343_r_at AV136210 DNA segment, Chr 17, ERATO Doi 315, expressed10239 0.73417 1.14 up Mm.30241 Ifi30 97444_at AI844520 interferon gamma inducible protein 3010240 0.73430 1.20 up Mm.24110 D2Ertd120e 104602_at AW121972 DNA segment, Chr 2, ERATO Doi 120, expressed10241 0.73432 1.09 up Mm.279 1110019N10Rik 95592_at AW046785 RIKEN cDNA 1110019N10 gene10242 0.73436 1.20 down Mm.38364 Mm.38364 97711_at AI606967 ESTs10243 0.73438 1.07 down Mm.180267 Mm.180267 161127_i_at AV294412 ESTs, Weakly similar to RL24_HUMAN 60S RIBOSOMAL PROTEIN L24 [R10244 0.73467 1.27 up Mm.8038 Zap70 93661_at U04379 zeta-chain (TCR) associated protein kinase (70kD)10245 0.73522 1.23 up Mm.123225 C80816 104257_g_at AI120844 expressed sequence C8081610246 0.73523 1.07 up Mm.29545 Pnkp 97332_at AI195478 polynucleotide kinase 3'- phosphatase10247 0.73531 1.12 down Mm.4919 D0H4S114 160522_at D45203 DNA segment, human D4S11410248 0.73533 1.18 down Mm.213078 Fv4 101288_at M33884 Friend virus susceptibility 410249 0.73548 1.08 up Mm.26364 B4galt6 102936_at AW125314 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 610250 0.73556 1.09 down Mm.200763 2900069C24Rik 104151_at AI553451 RIKEN cDNA 2900069C24 gene10251 0.73558 1.16 down Mm.27040 Ensa 93722_at AJ005985 endosulfine alpha10252 0.73562 1.08 up Mm.156320 Mm.156320 161688_r_at AV220094 ESTs10253 0.73599 1.15 up Mm.27609 Chaf1a 95527_at AJ132771 chromatin assembly factor 1, subunit A (p150)10254 0.73603 1.05 down Mm.3360 Ywhaz 104080_at AW212479 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,10255 0.73605 1.18 up Mm.57226 Dcc 102566_at X85788 deleted in colorectal carcinoma10256 0.73613 1.10 up Mm.42149 Rad53 92481_at AF086905 RAD53 homolog (S.cerevisiae)10257 0.73618 1.26 up Mm.149 Rad52 161727_r_at AV267115 RAD52 homolog, (S. cerevisiae)10258 0.73628 1.16 up Mm.41064 Rad23a 92410_at X92410 RAD23a homolog (S. cerevisiae)10259 0.73642 1.31 down Mm.153446 Pla2g5 101328_at U66873 phospholipase A2, group V10260 0.73649 1.08 down Mm.25316 AW538652 160207_at AW121639 expressed sequence AW538652Page 114 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description10261 0.73668 1.12 down Mm.46754 AI316867 94433_at AW060684 expressed sequence AI31686710262 0.73674 1.20 down Mm.16469 Nmyc1 161417_r_at AV320040 neuroblastoma myc-related oncogene 110263 0.73708 1.12 up Mm.4067 Lisch7-pending 99452_at U49507 liver-specific bHLH-Zip transcription factor10264 0.73713 1.20 up Mm.28595 2410018C03Rik 162416_at AV321707 RIKEN cDNA 2410018C03 gene10265 0.73728 1.09 down Mm.41475 Asna1 92428_at AF039405 arsA (bacterial) arsenite transporter, ATP-binding, homolog 110266 0.73740 1.13 down Mm.43133 R75078 92528_at AI851724 expressed sequence R7507810267 0.73741 1.18 up Mm.197694 Drr3 102010_at U51727 developmentally regulated repeat element-containing transcript 310268 0.73764 1.07 down Mm.180182 Cox5b 93119_at X53157 cytochrome c oxidase, subunit Vb10269 0.73765 1.12 up Mm.28407 Acyp2 104258_at AA881576 acylphosphatase 2, muscle type10270 0.73786 1.11 down Mm.28587 Map3k4 104272_s_at U85608 mitogen activated protein kinase kinase kinase 410271 0.73808 1.13 down Mm.30173 Mrp63 96931_at AW048260 mitochondrial ribosomal protein 6310272 0.73820 1.10 down Mm.29857 Nrgn 96273_at AI841709 neurogranin (protein kinase C substrate, RC3)10273 0.73835 1.12 up Mm.89320 Glra1 100385_at X75832 glycine receptor, alpha 1 subunit10274 0.73840 1.08 up Mm.205400 Mm.205400 96178_at AI850636 ESTs, Highly similar to histone acetyltransferase [H.sapiens]10275 0.73842 1.22 up Mm.28362 AI326478 97008_f_at L33943 expressed sequence AI32647810276 0.73856 1.18 up Mm.104747 Igk-V28 96964_at L14554 immunoglobulin kappa chain variable 28 (V28)10277 0.73857 1.06 up Mm.29504 Ssfa1 95650_at U95114 sperm specific antigen 110278 0.73868 1.11 up Mm.4049 Xpa 92384_at X74351 xeroderma pigmentosum, complementation group A10279 0.73872 1.11 down Mm.399 Ier2 99109_at M59821 immediate early response 210280 0.73880 1.07 down Mm.20837 Cln2 93595_at AF111172 ceroid-lipofuscinosis, neuronal 210281 0.73932 1.24 up Mm.29098 AU015645 162184_at AV367805 expressed sequence AU01564510282 0.73933 1.09 down Mm.20921 Igsf4 93604_f_at AF061260 immunoglobulin superfamily, member 410283 0.73949 1.09 down Mm.25072 Trfp 160724_at AJ245617 Trf (TATA binding protein-related factor)-proximal protein homolog (Drosoph10284 0.73953 1.22 up Mm.31325 Gdf15 104646_at AJ011967 growth differentiation factor 1510285 0.73979 1.14 down Mm.29737 C77284 95726_at AW120733 EST C7728410286 0.73988 1.20 down Mm.24941 D4Ertd117e 95960_at C77296 DNA segment, Chr 4, ERATO Doi 117, expressed10287 0.73993 1.12 up Mm.219665 Mm.219665 161925_at AV146226 Mus musculus, Similar to KIAA1089 protein, clone MGC:30464 IMAGE:399210288 0.74017 1.25 up Mm.4177 Ucp1 99507_at M21247 uncoupling protein 1, mitochondrial10289 0.74028 1.19 up Mm.3879 Hif1a 98629_f_at Y09085 hypoxia inducible factor 1, alpha subunit10290 0.74031 1.11 up Mm.4615 Dlgh3 160892_at D87117 discs, large homolog 3 (Drosophila)10291 0.74032 1.11 up Mm.19117 Ptbp1 162397_r_at AV274525 polypyrimidine tract binding protein 110292 0.74045 1.13 down Mm.486 Lamp2 101590_at AI747194 lysosomal membrane glycoprotein 210293 0.74053 1.24 up Mm.214981 Hist1 93022_i_at M32459 histone gene complex 110294 0.74061 1.07 up Mm.28782 Bcl10 94448_at AJ006289 B-cell leukemia/lymphoma 1010295 0.74068 1.10 down Mm.203935 D16Bwg1543e 104056_at AI573367 DNA segment, Chr 16, Brigham & Women's Genetics 1543 expressed10296 0.74090 1.15 up Mm.203928 Stx3 100498_g_at D38375 syntaxin 310297 0.74090 1.13 up Mm.9653 Gadd45g 101979_at AF055638 growth arrest and DNA-damage-inducible 45 gamma10298 0.74094 1.11 down Mm.569 Vdac2 160529_r_at U30838 voltage-dependent anion channel 210299 0.74095 1.16 down Mm.206909 AI842738 99477_at AI842738 expressed sequence AI84273810300 0.74099 1.07 down Mm.1921 2510002A14Rik 103567_at AW123810 RIKEN cDNA 2510002A14 gene10301 0.74101 1.23 up Mm.2807 Galgt2 96548_at L30104 UDP-N-acetyl-alpha-D-galactosamine:(N-acetylneuraminyl)-galactosyl-N-ace10302 0.74102 1.13 up Mm.21158 Frap1 94935_at AI843739 FK506 binding protein 12-rapamycin associated protein 110303 0.74112 1.15 up Mm.2820 Glk 161363_r_at AV217354 galactokinase10304 0.74114 1.18 up Mm.4774 Sim1 92895_at AF038857 single-minded 110305 0.74122 1.16 up Mm.202361 AW045841 95574_f_at AI641995 expressed sequence AW04584110306 0.74131 1.06 down Mm.666 Ndufc1 100628_at AI840263 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 110307 0.74131 1.16 up Mm.10694 Myoc 94122_at AF041335 myocilin10308 0.74138 1.04 up Mm.1358 M6pr 92847_s_at X56831 mannose-6-phosphate receptor, cation dependent10309 0.74139 1.06 down Mm.22049 Crip 94061_at M13018 cysteine rich in<strong>test</strong>inal protein10310 0.74140 1.16 up Mm.8028 Accn1 99910_at Y14634 amiloride-sensitive cation channel 1, neuronal (degenerin)10311 0.74142 1.26 down Mm.197839 C80913 161431_i_at AV306317 expressed sequence C8091310312 0.74162 1.15 down Mm.57033 Mm.57033 101348_at Z95479 M.musculus immunoglobulin kappa chain variable region10313 0.74169 1.19 up Mm.27779 2410154J16Rik 95562_at AA615127 RIKEN cDNA 2410154J16 gene10314 0.74188 1.21 down Mm.23955 Wbscr5 161899_f_at AV373730 Williams-Beuren syndrome chromosome region 5 homolog (human)10315 0.74189 1.15 up Mm.205021 Npnt 103721_at AA592182 nephronectin10316 0.74191 1.29 down Mm.179747 Itga7 160086_at Y12380 integrin alpha 710317 0.74201 1.09 up Mm.17221 Agl 94790_at AA681807 amylo-1,6-glucosidase, 4-alpha-glucanotransferase10318 0.74209 1.18 up Mm.138256 Gja9 101729_at AF016190 gap junction membrane channel protein alpha 910319 0.74212 1.13 up Mm.26486 Mm.26486 160993_at AI854813 ESTs, Weakly similar to IQG1_MOUSE Ras GTPase-activating-like protein I10320 0.74216 1.12 up Mm.10669 Gdc1 92592_at M25558 glycerol phosphate dehydrogenase 1, cytoplasmic adult10321 0.74233 1.04 up Mm.30248 Mm.30248 97933_at AW045317 Mus musculus, clone IMAGE:3589087, mRNA, partial cds10322 0.74238 1.18 down Mm.20847 Snx5 93597_at AA967585 sorting nexin 510323 0.74286 1.22 down Mm.4398 4933416E03Rik 98358_at AI505393 RIKEN cDNA 4933416E03 gene10324 0.74312 1.16 down Mm.42027 Kif1b 160871_at AB023656 kinesin heavy chain member 1B10325 0.74318 1.07 up Mm.34772 Gtf2a2 98101_at AI851798 general transcription factor II A, 2 (12kD subunit)10326 0.74323 1.23 up Mm.40915 Siat7e 92403_at AB030836 sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-ace10327 0.74324 1.09 up Mm.6539 Kcnh2 100961_at AF012871 potassium voltage-gated channel, subfamily H (eag-related), member 210328 0.74327 1.09 down Mm.210529 C77892 95007_at AI843564 expressed sequence C7789210329 0.74328 1.10 down Mm.212538 H2-Q8 97174_r_at M27134 histocompatibility 2, Q region locus 810330 0.74337 1.21 up Mm.5142 Nptx1 93134_at U62021 neuronal pentraxin 110331 0.74343 1.16 up Mm.28770 Jcam3 98957_at AI850297 junction cell adhesion molecule 310332 0.74344 1.13 down Mm.168744 Vamp3 98521_at AI847972 vesicle-associated membrane protein 310333 0.74354 1.13 up Mm.24057 Mm.24057 95890_r_at AA185884 ESTs, Weakly similar to S26689 hypothetical protein hc1 - mouse [M.muscu10334 0.74355 1.06 up Mm.6095 Cstb 100581_at U59807 cystatin B10335 0.74382 1.08 down Mm.14555 Ap2a2 102835_at X14972 adaptor protein complex AP-2, alpha 2 subunit10336 0.74415 1.30 up Mm.4834 Hyal2 161608_r_at AV348858 hyaluronidase 210337 0.74426 1.12 up Mm.4499 Cacna1c 98386_s_at U17869 calcium channel, voltage-dependent, L type, alpha 1C subunit10338 0.74439 1.20 down Mm.45078 4632433K11Rik 102119_at C80000 RIKEN cDNA 4632433K11 gene10339 0.74440 1.12 up Mm.2930 Mm.2930 160802_at AA674812 Mus musculus, Similar to peter pan (Drosophila) homolog, clone MGC:2566910340 0.74444 1.12 down Mm.4880 Cbln1 92932_at X61448 cerebellin 1 precursor protein10341 0.74457 1.25 up Mm.68712 Fzd4 95772_r_at U43317 frizzled homolog 4 (Drosophila)10342 0.74457 1.23 up Mm.3451 Fmr1 161875_at AV360766 fragile X mental retardation syndrome 1 homolog10343 0.74463 1.09 down Mm.14543 Edn1 102737_at U35233 endothelin 110344 0.74471 1.12 up Mm.200666 1110033G07Rik 97407_at AI848025 RIKEN cDNA 1110033G07 gene10345 0.74479 1.12 down Mm.20301 2810407K09Rik 103631_at AA985795 RIKEN cDNA 2810407K09 gene10346 0.74487 1.05 up Mm.2395 Mea1 94892_r_at M27938 male enhanced antigen 110347 0.74505 1.09 down Mm.177642 AU015269 95287_at AA189677 expressed sequence AU01526910348 0.74522 1.21 down Mm.153837 Kcnj1 103972_at AF012834 potassium inwardly-rectifying channel, subfamily J, member 110349 0.74549 1.09 down Mm.21086 Eef1d 160129_at AI839632 eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange10350 0.74585 1.06 up Mm.21299 AI195826 103895_at AW121745 expressed sequence AI195826Page 115 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description10351 0.74603 1.17 up Mm.4804 tub 98806_s_at U52824 tubby10352 0.74629 1.14 down Mm.203876 AA408650 161828_r_at AV022820 expressed sequence AA40865010353 0.74631 1.17 down Mm.140760 Kcnj4 92522_at U11075 potassium inwardly-rectifying channel, subfamily J, member 410354 0.74632 1.12 up Mm.42956 Nelf 162236_f_at AV327356 nasal embryonic LHRH factor10355 0.74672 1.22 down 101324_r_at L2416010356 0.74716 1.14 down Mm.28525 3110052N05Rik 98881_at AI853675 RIKEN cDNA 3110052N05 gene10357 0.74739 1.07 down Mm.20918 Nlvcf 93603_at AF034092 nuclear localization signal protein absent in velo-cardio-facial patients10358 0.74740 1.15 up Mm.42027 Kif1b 94379_at D17577 kinesin heavy chain member 1B10359 0.74749 1.04 down Mm.43784 1110025H10Rik 99658_f_at AW047907 RIKEN cDNA 1110025H10 gene10360 0.74761 1.09 down Mm.180410 4930566A11Rik 95123_at AI844003 RIKEN cDNA 4930566A11 gene10361 0.74766 1.11 down Mm.21834 Orc4 103500_at AI553463 origin recognition complex, subunit 410362 0.74782 1.18 down Mm.39001 1110018N15Rik 92337_g_at AI834936 RIKEN cDNA 1110018N15 gene10363 0.74802 1.14 down Mm.4663 Ptx3 92731_at X83601 pentaxin related gene10364 0.74806 1.11 down Mm.2214 4-Sep 98905_at AJ223782 septin 410365 0.74819 1.10 up Mm.29067 AI194990 94542_at AA929348 expressed sequence AI19499010366 0.74834 1.16 up Mm.179747 Itga7 161497_f_at AV093331 integrin alpha 710367 0.74836 1.06 up Mm.4336 Ext2 99929_at U72141 exostoses (multiple) 210368 0.74844 1.11 up Mm.21925 Ela2 94037_at X04573 elastase 210369 0.74855 1.06 up Mm.1007 Psma3 92544_f_at AF055983 proteasome (prosome, macropain) subunit, alpha type 310370 0.74860 1.27 up Mm.3968 Map3k7 161672_at AV144734 mitogen activated protein kinase kinase kinase 710371 0.74898 1.10 up Mm.158068 Styx 92888_s_at U34973 phosphoserine/threonine/tyrosine interaction protein10372 0.74934 1.15 up Mm.195371 D15Ertd336e 96393_at C80871 DNA segment, Chr 15, ERATO Doi 336, expressed10373 0.74963 1.09 down Mm.162 Mafk 102919_at D42124 v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)10374 0.75000 1.15 up Mm.1278 Pip 94151_at AB017918 prolactin induced protein10375 0.75001 1.12 up Mm.2310 ORF6 104528_at AI181549 open reading frame 610376 0.75039 1.14 up Mm.5789 Mm.5789 101602_at C79108 ESTs10377 0.75040 1.15 up Mm.190642 Mm.190642 92260_at Y17678 Mus musculus mRNA containing B1 element, clone vario10378 0.75052 1.21 down Mm.2547 Dad1 161896_at AV104330 defender against cell death 110379 0.75065 1.11 up Mm.214970 Mm.214970 160351_at AI846531 Mus musculus, Similar to aminopeptidase B, clone MGC:29229 IMAGE:504110380 0.75067 1.25 down Mm.4935 Npn2 101156_at Z31359 neoplastic progression 210381 0.75069 1.10 down Mm.12958 Klc2 102636_at AF055666 kinesin light chain 210382 0.75079 1.18 down Mm.133447 Smarca5 97394_at AA794509 SWI/SNF related, matrix associated, actin dependent regulator of chromatin,10383 0.75081 1.13 down Mm.29434 Zfp161 96836_r_at AI447619 zinc finger protein 16110384 0.75094 1.12 down Mm.3181 Arhgef1 98001_at U58203 Rho guanine nucleotide exchange factor (GEF) 110385 0.75105 1.10 down Mm.22379 Mm.22379 160686_at AI836015 Mus musculus, Similar to hypothetical protein FLJ13213, clone MGC:2855510386 0.75107 1.12 down Mm.200687 D8Wsu49e 93530_at AI842807 DNA segment, Chr 8, Wayne State University 49, expressed10387 0.75120 1.10 up Mm.23975 2400007G07Rik 104582_g_at AI845438 RIKEN cDNA 2400007G07 gene10388 0.75164 1.10 up Mm.212846 Mm.212846 96216_at AI848826 Mus musculus, Similar to hypothetical protein, clone MGC:19257 IMAGE:39810389 0.75179 1.10 down Mm.2962 2610019M19Rik 97349_at AA727410 RIKEN cDNA 2610019M19 gene10390 0.75189 1.10 down Mm.181538 2610007K22Rik 162424_f_at AV291989 RIKEN cDNA 2610007K22 gene10391 0.75194 1.15 down Mm.4366 Ebf 92535_at L12147 early B-cell factor10392 0.75209 1.04 down Mm.2112 Ech1 93754_at AF030343 enoyl coenzyme A hydratase 1, peroxisomal10393 0.75222 1.09 down Mm.26644 1810055D05Rik 94925_at AA754865 RIKEN cDNA 1810055D05 gene10394 0.75223 1.26 down 97739_at U2078010395 0.75242 1.05 down Mm.30043 5730406I15Rik 96855_at AI839946 RIKEN cDNA 5730406I15 gene10396 0.75247 1.06 down Mm.22701 Gas1 94813_at X65128 growth arrest specific 110397 0.75259 1.15 down Mm.4688 Spam 92743_at U33958 sperm adhesion molecule10398 0.75267 1.11 down Mm.935 Sdf2 101967_at D50646 stromal cell derived factor 210399 0.75296 1.20 up Mm.4921 Gria2 92947_s_at X57498 glutamate receptor, ionotropic, AMPA2 (alpha 2)10400 0.75298 1.15 down Mm.4777 Orm1 100437_g_at M27008 orosomucoid 110401 0.75311 1.08 up Mm.20921 Igsf4 93606_s_at AB021966 immunoglobulin superfamily, member 410402 0.75325 1.08 up Mm.41943 Pik3ca 104461_at AW121773 phosphatidylinositol 3-kinase, catalytic, alpha polypeptide10403 0.75332 1.11 up Mm.4966 Tnfrsf5 92962_at M83312 tumor necrosis factor receptor superfamily, member 510404 0.75354 1.16 up Mm.30088 Clpx 94962_g_at AI851962 caseinolytic protease X (E.coli)10405 0.75370 1.13 down Mm.4082 Emk 99459_f_at X70764 ELKL motif kinase10406 0.75373 1.07 down Mm.155033 Mrpl4 95736_at AI847546 mitochondrial ribosomal protein L410407 0.75377 1.10 up Mm.4807 Ocln 92907_at U49185 occludin10408 0.75380 1.12 down Mm.212897 Mm.212897 100048_at AW049685 Mus musculus, Similar to RAP1A, member of RAS oncogene family, clone M10409 0.75412 1.16 up Mm.22562 Gabt2 103510_at M97632 gamma-aminobutyric acid (GABA-A) transporter 210410 0.75421 1.10 down Mm.18654 Mm.18654 103391_at AI988033 ESTs, Weakly similar to S48737 kynurenine aminotransferase - rat [R.norveg10411 0.75425 1.09 up Mm.10541 1500009K01Rik 160581_at AI848078 RIKEN cDNA 1500009K01 gene10412 0.75437 1.06 down Mm.1098 Gpiap1 92611_at U18773 GPI-anchored membrane protein 110413 0.75451 1.13 down Mm.21586 Srcasm 104063_at AI840130 Src activating and signaling molecule10414 0.75465 1.09 up Mm.25039 C79529 95986_at C79529 expressed sequence C7952910415 0.75477 1.09 up Mm.22541 9130005N23Rik 160689_r_at AW121848 RIKEN cDNA 9130005N23 gene10416 0.75481 1.09 down Mm.26600 6330505C01Rik 104003_at AA822296 RIKEN cDNA 6330505C01 gene10417 0.75544 1.14 down Mm.37203 Pl2 160443_at M14647 placental lactogen 210418 0.75571 1.15 down Mm.196 Nedd8 162180_r_at AV367714 neural precursor cell expressed, developmentally down-regulated gene 810419 0.75580 1.06 up Mm.27932 Ars2-pending 97273_at AI845953 arsenate resistance protein 210420 0.75613 1.24 down Mm.43212 1500031M19Rik 161979_f_at AV230529 RIKEN cDNA 1500031M19 gene10421 0.75618 1.06 down Mm.27535 Mm.27535 95033_at AW049513 Mus musculus, clone IMAGE:4976380, mRNA, partial cds10422 0.75637 1.11 down Mm.89110 5031401C21Rik 97705_at AI122204 RIKEN cDNA 5031401C21 gene10423 0.75663 1.11 up Mm.6710 Rock1 160746_at AA647393 Rho-associated coiled-coil forming kinase 110424 0.75671 1.14 up Mm.4452 Ahr 160495_at M94623 aryl-hydrocarbon receptor10425 0.75679 1.12 up Mm.8211 Pja1 101462_r_at U06944 praja1, RING-H2 motif containing10426 0.75689 1.15 down Mm.24481 AA407151 94663_at AA407151 expressed sequence AA40715110427 0.75697 1.08 down Mm.22435 Golph3 160688_at AW060175 golgi phosphoprotein 310428 0.75701 1.22 up Mm.155711 Ceacam2 101907_s_at X76085 CEA-related cell adhesion molecule 210429 0.75730 1.21 down Mm.22480 Dmtf1 94271_at U70017 cyclin D binding myb-like transcription factor 110430 0.75736 1.21 up Mm.7405 Bat4 101415_i_at L76155 HLA-B associated transcript 410431 0.75750 1.15 up Mm.24792 Mm.24792 162250_f_at AV173341 ESTs10432 0.75775 1.10 up Mm.195067 Actn2 160570_at AI931692 actinin alpha 210433 0.75779 1.08 up Mm.19370 Atp5k 102561_at U59282 ATP synthase, H+ transporting, mitochondrial F1F0 complex, subunit e10434 0.75788 1.06 up Mm.3200 1300017K07Rik 97098_at AI838360 RIKEN cDNA 1300017K07 gene10435 0.75794 1.16 up Mm.96 Itgae 93961_at U12236 integrin, alpha E, epithelial-associated10436 0.75795 1.10 down Mm.21559 Nono 93830_at AI851199 non-POU-domain-containing, octamer binding protein10437 0.75813 1.09 down Mm.41537 Catnbip1 99492_at AI851990 catenin beta interacting protein 110438 0.75818 1.17 down Mm.41886 Gfra2 92448_s_at AF079107 glial cell line derived neurotrophic factor family receptor alpha 210439 0.75818 1.09 up Mm.3126 Fhl1 97498_at U41739 four and a half LIM domains 110440 0.75825 1.13 down Mm.38674 Sytl4 161026_s_at AB025259 synaptotagmin-like 4Page 116 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description10441 0.75854 1.08 up Mm.200783 AU014939 96724_r_at AW122911 expressed sequence AU01493910442 0.75859 1.12 up Mm.4839 Acvrl1 100448_at Z31664 activin A receptor, type II-like 110443 0.75871 1.10 up Mm.2792 Ptgs1 161694_f_at AV230409 prostaglandin-endoperoxide synthase 110444 0.75881 1.13 up Mm.10022 Homer3-pending 102014_at AF093261 homer, neuronal immediate early gene, 310445 0.75914 1.09 up Mm.1103 2010003O02Rik 92615_at AI853615 RIKEN cDNA 2010003O02 gene10446 0.75915 1.15 up Mm.4869 Rel 98813_at X60271 reticuloendotheliosis oncogene10447 0.75927 1.15 up Mm.4369 Adrb3 92537_g_at X72862 adrenergic receptor, beta 310448 0.75937 1.22 down Mm.1284 Il13 94168_at M23504 interleukin 1310449 0.75952 1.15 up Mm.2036 Ifit2 103639_at U43085 interferon-induced protein with tetratricopeptide repeats 210450 0.75960 1.21 down Mm.25652 Gjb6 102571_at Z70023 gap junction membrane channel protein beta 610451 0.75964 1.22 up Mm.153893 Psg-ps1 97086_i_at M83348 pregnancy specific glycoprotein pseudogene 110452 0.75969 1.14 up 97578_at AF09980710453 0.75992 1.13 up Mm.85763 D4Ertd27e 99777_s_at C76650 DNA segment, Chr 4, ERATO Doi 27, expressed10454 0.75995 1.05 down Mm.27269 2310037I24Rik 94978_at AI839775 RIKEN cDNA 2310037I24 gene10455 0.76012 1.16 up Mm.28800 Mm.28800 96237_at AI118905 ESTs10456 0.76014 1.13 down Mm.891 Kifc2 93890_at D49545 kinesin family member C210457 0.76021 1.10 down Mm.6925 Sec8 93466_at AF022962 SEC8 (S. cerevisiae)10458 0.76023 1.05 up Mm.27723 Fem1a 160244_at AI836048 feminization 1 homolog a (C. elegans)10459 0.76026 1.13 up Mm.215095 AI481716 104488_at AI852101 expressed sequence AI48171610460 0.76031 1.06 down Mm.22138 1110020P15Rik 94078_at AW046239 RIKEN cDNA 1110020P15 gene10461 0.76046 1.20 up Mm.19353 LOC56304 96974_at X82688 recombinant antineuraminidase single chain Ig VH and VL domains10462 0.76046 1.07 up Mm.4532 Mm.4532 100007_at AI837573 Mus musculus, clone MGC:29437 IMAGE:3962494, mRNA, complete cds10463 0.76066 1.12 down Mm.41440 AI839920 92424_at AI843426 expressed sequence AI83992010464 0.76069 1.27 up Mm.8122 Tenr 161388_f_at AV254224 <strong>test</strong>is nuclear RNA binding protein10465 0.76094 1.06 up Mm.24875 Mrps18a 104767_f_at AW060921 mitochondrial ribosomal protein S18A10466 0.76094 1.10 down Mm.33797 Hdac7a 97550_at AW047228 histone deacetylase 7A10467 0.76095 1.16 down Mm.34407 Madh7 92216_at AF015260 MAD homolog 7 (Drosophila)10468 0.76097 1.05 up Mm.28124 Gfer 160269_at U40494 growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)10469 0.76106 1.10 down Mm.67938 Cstf2 104399_at AI850965 cleavage stimulation factor, 3' pre-RNA subunit 2, 64 kDa10470 0.76119 1.04 up Mm.183076 2510039O18Rik 162292_r_at AV377060 RIKEN cDNA 2510039O18 gene10471 0.76125 1.08 down Mm.24229 2010300G19Rik 104620_at AW123402 RIKEN cDNA 2010300G19 gene10472 0.76132 1.18 down Mm.21025 Zfp40 95244_at D10632 zinc finger protein 4010473 0.76138 1.13 up Mm.16525 Plk 101350_g_at U73170 polo-like kinase homolog, (Drosophila)10474 0.76176 1.22 down Mm.4654 Ptpn5 100406_at U28217 protein tyrosine phosphatase, non-receptor type 510475 0.76176 1.20 down Mm.22116 AI507170 161565_r_at AV268143 expressed sequence AI50717010476 0.76200 1.13 up Mm.27973 Kif3b 161003_at D26077 kinesin family member 3b10477 0.76202 1.11 up Mm.1376 Creb1 102673_at X67719 cAMP responsive element binding protein 110478 0.76203 1.15 up Mm.13866 Madcam1 102680_g_at D50434 mucosal vascular addressin cell adhesion molecule 110479 0.76258 1.14 up Mm.23304 Tmeff2 103536_at AB017270 transmembrane protein with EGF-like and two follistatin-like domains 210480 0.76288 1.10 down Mm.132412 Mm.132412 95285_at AI153315 Mus musculus, Similar to zinc finger protein s11-6, clone MGC:36909 IMAGE10481 0.76298 1.08 down Mm.22031 Cstf2t-pending 104126_at AI854864 cleavage stimulation factor, 3' pre-RNA subunit 2, 64 kDa, tau10482 0.76323 1.14 down Mm.4732 Lamb3 161188_f_at AV238648 laminin, beta 310483 0.76332 1.07 down Mm.2475 Gcdh 160194_at U18992 glutaryl-Coenzyme A dehydrogenase10484 0.76337 1.12 up Mm.3109 Ctsk 160406_at AJ006033 cathepsin K10485 0.76346 1.12 up Mm.14733 Defcr-rs12 101795_f_at U12566 defensin related cryptdin, related sequence 1210486 0.76357 1.20 up Mm.137268 Hes5 162069_at AV309741 hairy and enhancer of split 5, (Drosophila)10487 0.76383 1.13 up Mm.194795 Mgll 97510_at AJ001118 monoglyceride lipase10488 0.76392 1.08 down Mm.24109 Mm.24109 103712_at AW124735 ESTs, Moderately similar to Y029_HUMAN HYPOTHETICAL PROTEIN KIAA10489 0.76415 1.09 up Mm.219448 AA408168 104480_at AI152659 expressed sequence AA40816810490 0.76425 1.12 up Mm.4283 Bop1 160878_at AF061503 block of proliferation 110491 0.76429 1.15 up Mm.21397 2310047E01Rik 103905_at AI314958 RIKEN cDNA 2310047E01 gene10492 0.76440 1.05 down Mm.142498 0610011L04Rik 95064_at AI849271 RIKEN cDNA 0610011L04 gene10493 0.76463 1.06 down Mm.53 1810058I24Rik 100877_at AI194274 RIKEN cDNA 1810058I24 gene10494 0.76479 1.12 down Mm.24902 Mm.24902 95947_at C76331 ESTs10495 0.76482 1.22 up Mm.25455 Mm.25455 104037_at AI834891 Mus musculus adult male <strong>test</strong>is cDNA, RIKEN full-length enriched library, clo10496 0.76488 1.18 up Mm.37619 Mm.37619 97690_at AA396040 ESTs10497 0.76496 1.05 down Mm.4890 Fau 99422_at U53591 Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expresse10498 0.76510 1.17 up Mm.4727 Sez6 92757_at D29763 seizure related gene 610499 0.76517 1.07 down Mm.3594 Banp 98512_at AF091234 Btg3 associated nuclear protein10500 0.76523 1.11 up Mm.21002 Slc2a1 93738_at M22998 solute carrier family 2 (facilitated glucose transporter), member 110501 0.76528 1.07 up Mm.22421 Tebp-pending 94259_at AB024935 telomerase binding protein, p2310502 0.76530 1.14 up Mm.45532 2810043O03Rik 98756_at W91704 RIKEN cDNA 2810043O03 gene10503 0.76540 1.06 up Mm.25727 D17Wsu94e 160211_at AI846885 DNA segment, Chr 17, Wayne State University 94, expressed10504 0.76561 1.14 up Mm.2787 Amacr 95588_at U89906 alpha-methylacyl-CoA racemase10505 0.76568 1.18 down Mm.199702 AW047046 161041_at AW047046 expressed sequence AW04704610506 0.76571 1.10 up Mm.28543 Efs 96195_at U57686 embryonal Fyn-associated substrate10507 0.76572 1.05 down Mm.200894 C78391 160885_at AW120755 expressed sequence C7839110508 0.76595 1.08 down Mm.28994 Mm.28994 96758_s_at AI172965 Mus musculus, clone MGC:6302 IMAGE:2655022, mRNA, complete cds10509 0.76614 1.11 up Mm.29742 Pa26-pending 95731_at AI843106 p53 regulated PA26 nuclear protein10510 0.76631 1.07 down Mm.10278 1110005A23Rik 92565_at AI847109 RIKEN cDNA 1110005A23 gene10511 0.76634 1.12 up Mm.22896 Mm.22896 95377_at AI643731 ESTs10512 0.76654 1.10 up Mm.184314 Mm.184314 96925_at AW122429 ESTs, Weakly similar to procollagen-lysine 5-dioxygenase [R.norvegicus]10513 0.76678 1.08 up Mm.222 Trp53 101618_r_at U59758 transformation related protein 5310514 0.76680 1.11 up Mm.200649 Arih1 95563_at AJ130977 ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosop10515 0.76681 1.12 up Mm.4824 Syt3 102116_f_at AI836330 synaptotagmin 310516 0.76693 1.20 up Mm.7241 Slc2a8 161555_f_at AV252603 solute carrier family 2, (facilitated glucose transporter), member 810517 0.76702 1.23 up Mm.1268 Plp 160926_r_at AI837266 proteolipid protein (myelin)10518 0.76728 1.17 down Mm.42185 Slc22a4 92497_at AB016257 solute carrier family 22 (organic cation transporter), member 410519 0.76736 1.06 down Mm.30214 0610006O14Rik 96955_at AI841320 RIKEN cDNA 0610006O14 gene10520 0.76758 1.24 down Mm.30300 Ceacam10 101637_at L38422 CEA-related cell adhesion molecule 1010521 0.76762 1.11 up Mm.24368 AV253134 95906_at AA867818 expressed sequence AV25313410522 0.76764 1.19 up Mm.4627 Npr1 100035_at L31932 natriuretic peptide receptor 110523 0.76770 1.19 down Mm.29063 2410022L05Rik 96780_at AW208818 RIKEN cDNA 2410022L05 gene10524 0.76777 1.08 down Mm.22663 Sqle 94322_at D42048 squalene epoxidase10525 0.76781 1.10 up 96976_f_at X1621710526 0.76781 1.07 up Mm.22548 2410133M08Rik 104349_at AA870301 RIKEN cDNA 2410133M08 gene10527 0.76789 1.10 up Mm.22724 Plaa 94825_at M57958 phospholipase A2, activating protein10528 0.76799 1.16 down Mm.83146 Mm.83146 161173_f_at AV229143 ESTs10529 0.76802 1.09 down Mm.4515 Cyp2f2 100069_at M77497 cytochrome P450, 2f210530 0.76807 1.09 up Mm.21965 D5Ertd593e 104116_at AW124049 DNA segment, Chr 5, ERATO Doi 593, expressedPage 117 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description10531 0.76808 1.03 down Mm.17224 Spop 160096_at AW122452 speckle-type POZ protein10532 0.76846 1.09 up Mm.25154 Wtap 162094_f_at AV339425 Wilms' tumour 1-associating protein10533 0.76847 1.11 up Mm.27818 Eef2 97559_at M76131 eukaryotic translation elongation factor 210534 0.76861 1.06 up Mm.7353 Ubl1 101091_at AF033353 ubiquitin-like 110535 0.76893 1.12 up Mm.57221 Hoxb13 99808_at U57051 homeo box B1310536 0.76897 1.09 down Mm.29797 Lrrfip2 160818_at AW124130 leucine rich repeat (in FLII) interacting protein 210537 0.76898 1.10 up Mm.1813 Cct5 93295_at Z31555 chaperonin subunit 5 (epsilon)10538 0.76920 1.08 down Mm.3019 Tead2 96940_at Y10026 TEA domain family member 210539 0.76936 1.19 up Mm.42103 Gpr49 98297_at AF110818 G protein-coupled receptor 4910540 0.76938 1.15 up Mm.120807 Ces3 101538_i_at AW226939 carboxylesterase 310541 0.76953 1.13 up Mm.12945 Pik3r2 102759_at Y13569 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)10542 0.76954 1.13 up Mm.4494 Pkp1 97601_f_at AW259538 plakophilin 110543 0.76957 1.16 down Mm.202246 AA408956 96534_at AA408956 expressed sequence AA40895610544 0.76961 1.11 down Mm.121973 AW554572 104284_at AI846126 expressed sequence AW55457210545 0.76962 1.12 up Mm.25064 C80171 96374_at C80171 expressed sequence C8017110546 0.76981 1.11 up Mm.14287 Hspa1l 92656_at AF109906 heat shock 70kD protein 1-like10547 0.76998 1.06 up Mm.24646 5430419M09Rik 160716_at AI838550 RIKEN cDNA 5430419M09 gene10548 0.77007 1.11 up Mm.4723 Sct 92755_f_at X73580 secretin10549 0.77009 1.15 up Mm.4629 Icam5 92714_at U06483 intercellular adhesion molecule 5, telencephalin10550 0.77025 1.21 down Mm.33083 Atp8a1 100315_at U75321 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 110551 0.77049 1.08 down Mm.153895 C79248 94689_at C79248 expressed sequence C7924810552 0.77051 1.08 up Mm.56901 Olfr41 101280_at AF106007 olfactory receptor 4110553 0.77053 1.15 up Mm.14022 Cox8a 92860_at U37721 cytochrome c oxidase, subunit VIIIa10554 0.77064 1.14 down Mm.38607 1300004G08Rik 98621_at AI842920 RIKEN cDNA 1300004G08 gene10555 0.77092 1.06 up Mm.24641 2810405J04Rik 95451_at AA855382 RIKEN cDNA 2810405J04 gene10556 0.77106 1.13 down Mm.30258 2810407L07Rik 97936_at AI527612 RIKEN cDNA 2810407L07 gene10557 0.77114 1.12 down Mm.147 Hoxa7 102864_at M17192 homeo box A710558 0.77120 1.26 up Mm.15621 Cftr 161904_f_at AV374675 cystic fibrosis transmembrane conductance regulator homolog10559 0.77123 1.11 up Mm.29408 AA589584 160340_at AI835714 expressed sequence AA58958410560 0.77128 1.13 up Mm.30438 Tyrp1 97954_at X59513 tyrosinase-related protein 110561 0.77136 1.13 up Mm.4444 Hoxc6 99980_at M35986 homeo box C610562 0.77136 1.04 up Mm.29877 Ubap 96286_at AW060996 ubiquitin-associated protein10563 0.77167 1.22 up Mm.7634 Lbcl1 93631_at X95761 lymphoid blast crisis-like 110564 0.77167 1.16 up Mm.4407 Adn 99671_at X04673 adipsin10565 0.77177 1.17 down Mm.30386 Homer1-pending 104498_at AF093257 homer, neuronal immediate early gene, 110566 0.77183 1.18 up Mm.195104 D0Kist2 98764_at U80889 DNA segment, KIST 210567 0.77187 1.14 up Mm.8017 Esx1 99906_at AF085715 extraembryonic, spermatogenesis, homeobox 110568 0.77193 1.18 up Mm.206727 D1Pas1 93200_f_at J04847 DNA segment, Chr 1, Pasteur Institute 110569 0.77193 1.10 up Mm.29751 Pycs 95738_at AW124889 pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthet10570 0.77194 1.07 down Mm.4022 1110033C18Rik 99078_at AI839522 RIKEN cDNA 1110033C18 gene10571 0.77198 1.06 down Mm.28371 3110001O07Rik 96166_at AI842524 RIKEN cDNA 3110001O07 gene10572 0.77214 1.12 down Mm.17461 Stk16 162157_f_at AV337942 serine/threonine kinase 1610573 0.77224 1.11 up Mm.29020 Cdkn2d 94521_at U19597 cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)10574 0.77228 1.08 down Mm.206404 Mm.206404 96942_at AI844011 Mus musculus mRNA for 67 kDa polymerase-associated factor PAF67 (paf610575 0.77239 1.10 up Mm.6442 Pkd2 100951_at AF014010 polycystic kidney disease 210576 0.77241 1.08 down Mm.140785 Scd1 94057_g_at M21285 stearoyl-Coenzyme A desaturase 110577 0.77243 1.18 up Mm.1161 Zfp185 102275_at U46687 zinc finger protein 18510578 0.77259 1.08 up Mm.142729 Tmsb4x 96426_at U38967 thymosin, beta 4, X chromosome10579 0.77260 1.07 up Mm.24276 C1r 161563_r_at AV266785 complement component 1, r subcomponent10580 0.77264 1.16 up Mm.6260 Foxf2 99846_at Y12293 forkhead box F210581 0.77265 1.08 down Mm.3036 AI874685 104494_at AI642098 expressed sequence AI87468510582 0.77276 1.13 up Mm.182470 2400006P09Rik 96106_at AW049122 RIKEN cDNA 2400006P09 gene10583 0.77279 1.21 down Mm.42948 Prdx2 101804_at AF032715 peroxiredoxin 210584 0.77279 1.09 down Mm.27054 AA408153 104034_at AI846672 expressed sequence AA40815310585 0.77280 1.09 up Mm.196884 Cpsf4 101371_at AF033201 cleavage and polyadenylation specific factor 4, 30kD subunit10586 0.77282 1.23 up Mm.41642 Rgs4 94155_at AB004315 regulator of G-protein signaling 410587 0.77282 1.12 up Mm.5356 AU016588 93174_at AI593640 expressed sequence AU01658810588 0.77289 1.06 down Mm.29801 Mm.29801 95760_at AI848730 Mus musculus, hypothetical protein MGC4549, clone MGC:29916 IMAGE:5110589 0.77316 1.12 up Mm.3332 2900024N03Rik 161020_r_at AI508500 RIKEN cDNA 2900024N03 gene10590 0.77331 1.06 up Mm.46856 Pawr 93439_f_at AA260005 PRKC, apoptosis, WT1, regulator10591 0.77353 1.10 down Mm.38976 AA409661 99086_g_at AI021421 expressed sequence AA40966110592 0.77371 1.07 up Mm.181721 2610041P16Rik 99115_at AW046350 RIKEN cDNA 2610041P16 gene10593 0.77377 1.15 up Mm.4789 Ank1 100441_s_at X69064 ankyrin 1, erythroid10594 0.77389 1.15 up Mm.1376 Creb1 102672_g_at X67719 cAMP responsive element binding protein 110595 0.77397 1.19 up Mm.835 Mm.835 101470_at AI851014 ESTs10596 0.77405 1.22 up Mm.139817 Omd 93369_at AB007848 osteomodulin10597 0.77414 1.19 up Mm.1205 Rpr1 94139_at L08075 rod photoreceptor 110598 0.77436 1.06 down Mm.29490 D10Ertd73e 161879_r_at AV366282 DNA segment, Chr 10, ERATO Doi 73, expressed10599 0.77440 1.24 up Mm.13145 Umps 162071_i_at AV311155 uridine monophosphate synthetase10600 0.77442 1.09 down Mm.30197 Snap23 96945_at U73143 synaptosomal-associated protein, 23kD10601 0.77453 1.11 down Mm.100863 AA409370 92299_at AI159504 expressed sequence AA40937010602 0.77462 1.15 up Mm.21482 Clns1a 101295_s_at U72059 chloride channel, nucleotide-sensitive, 1A10603 0.77475 1.08 up Mm.23975 2400007G07Rik 104583_at AI227492 RIKEN cDNA 2400007G07 gene10604 0.77475 1.15 down Mm.21013 Gro1 95348_at J04596 GRO1 oncogene10605 0.77481 1.04 up Mm.88295 Crry 101879_s_at M23529 complement receptor related protein10606 0.77497 1.16 down Mm.2118 Rgn 93766_at U32170 regucalcin10607 0.77501 1.06 down Mm.29962 Skz1-pending 96327_at AI852535 SCAN-KRAB-zinc finger gene 110608 0.77513 1.10 up Mm.6839 Cdk4 101017_at AA791962 cyclin-dependent kinase 410609 0.77515 1.13 down Mm.4934 Hsf2 101155_at X61754 heat shock factor 210610 0.77517 1.10 down Mm.4292 Tieg 99602_at AF064088 TGFB inducible early growth response10611 0.77536 1.16 up Mm.22302 Gzmm 95363_at AB015728 granzyme M (lymphocyte met-ase 1)10612 0.77548 1.06 down Mm.203968 1810015H18Rik 99604_at AI848713 RIKEN cDNA 1810015H18 gene10613 0.77548 1.09 down Mm.148781 Ranbp9 97812_at AF006465 RAN binding protein 910614 0.77548 1.12 up Mm.52977 9030624C24Rik 93162_f_at AF045953 RIKEN cDNA 9030624C24 gene10615 0.77553 1.07 down Mm.5545 2410001M24Rik 100892_at AI850186 RIKEN cDNA 2410001M24 gene10616 0.77571 1.13 down Mm.34588 Tna 92224_at X79199 tetranectin (plasminogen binding protein)10617 0.77574 1.11 up Mm.16080 Dnm 103030_at L31397 dynamin10618 0.77575 1.10 down 101754_f_at AJ00556510619 0.77577 1.10 up Mm.181830 Ntan1 162083_f_at AV313457 N-terminal Asn amidase10620 0.77579 1.12 down Mm.42257 Tekt1 99545_at AF081947 tektin 1Page 118 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description10621 0.77584 1.06 up Mm.28275 Rbmx 97847_at AJ237847 RNA binding motif protein, X chromosome10622 0.77603 1.14 up Mm.7254 Ebi3 93608_at AF013114 Epstein-Barr virus induced gene 310623 0.77631 1.05 down 94135_at M7698710624 0.77645 1.19 up Mm.28697 2310032D16Rik 98942_r_at AW125284 RIKEN cDNA 2310032D16 gene10625 0.77660 1.04 up Mm.4296 Ss18 99610_at X93357 synovial sarcoma translocation, Chromosome 1810626 0.77679 1.05 up Mm.30272 1200003M11Rik 97460_at AW122823 RIKEN cDNA 1200003M11 gene10627 0.77706 1.14 down Mm.124 Tmpo 92781_at U39073 thymopoietin10628 0.77714 1.19 down Mm.3159 Phkg 97094_at J03293 phosphorylase kinase gamma10629 0.77716 1.06 down Mm.29296 1110003H02Rik 95091_at AI839895 RIKEN cDNA 1110003H02 gene10630 0.77731 1.04 up Mm.10225 Ppl 102223_at AF013715 periplakin10631 0.77733 1.20 up Mm.30228 Sntb2 104489_at U00678 syntrophin, basic 210632 0.77748 1.06 down Mm.131074 C030048H19Rik 92526_f_at AW122114 RIKEN cDNA C030048H19 gene10633 0.77761 1.16 up Mm.57194 L1cam 99800_at X12875 L1 cell adhesion molecule10634 0.77801 1.20 up Mm.89974 Ube1y1 162396_at AV274077 ubiquitin-activating enzyme E1, Chr Y 110635 0.77804 1.07 up Mm.28427 Lt1 160782_at AI846418 lurcher transcript 110636 0.77833 1.08 down Mm.38268 Hdgfrp2 98599_at D63850 hepatoma-derived growth factor, related protein 210637 0.77835 1.36 down Mm.45511 Mm.45511 162322_r_at AV074196 ESTs10638 0.77842 1.21 down Mm.93826 Mm.93826 161449_f_at AV356018 ESTs10639 0.77843 1.17 up Mm.3264 Txk 104679_at D43963 TXK tyrosine kinase10640 0.77870 1.04 up Mm.142132 Timm9 94210_at AW121333 translocase of inner mitochondrial membrane 9 homolog (yeast)10641 0.77874 1.19 down Mm.29434 Zfp161 96474_at L15325 zinc finger protein 16110642 0.77880 1.13 up Mm.20465 Gpr37 103252_at AJ223834 G protein-coupled receptor 3710643 0.77892 1.11 down Mm.3425 Agpt2 92210_at AF004326 angiopoietin 210644 0.77898 1.11 up Mm.29350 Sdc2 95104_at U00674 syndecan 210645 0.77899 1.06 up Mm.20491 A430101B06Rik 160125_at AI852768 RIKEN cDNA A430101B06 gene10646 0.77920 1.10 down Mm.821 Snrpa1 101506_at AW227345 U2 small nuclear ribonucleoprotein polypeptide A'10647 0.77931 1.11 down Mm.5066 Zfp93 92990_at U46186 zinc finger protein 9310648 0.77939 1.12 up Mm.23501 Mm.23501 103540_at AA426714 ESTs10649 0.77958 1.07 up Mm.1363 Trh 102665_at X59387 thyrotropin releasing hormone10650 0.77959 1.10 down Mm.1290 Tcte1 102747_at M28821 t-complex-associated <strong>test</strong>is expressed 110651 0.77979 1.20 down Mm.30374 Crygc 96586_at Z22574 crystallin, gamma C10652 0.78004 1.11 up Mm.57149 Galr2 99430_at AF042784 galanin receptor 210653 0.78004 1.07 down Mm.202282 AU024026 104244_at AI606891 expressed sequence AU02402610654 0.78006 1.06 down Mm.30233 Ube2n 96959_at AW210080 ubiquitin-conjugating enzyme E2N10655 0.78009 1.14 up Mm.8035 Hand2 99914_at U43715 heart and neural crest derivatives expressed transcript 210656 0.78021 1.15 down Mm.29415 1810011O01Rik 160342_r_at AA939673 RIKEN cDNA 1810011O01 gene10657 0.78033 1.09 down Mm.23747 Mprs16 94866_at AI848915 mitochondrial ribosomal protein S1610658 0.78086 1.15 up Mm.2552 Reg3a 103954_at D63357 regenerating islet-derived 3 alpha10659 0.78088 1.19 up Mm.20892 Syn2 160954_at AF096867 synapsin II10660 0.78119 1.07 up Mm.141945 5730591C18Rik 160385_at AI851345 RIKEN cDNA 5730591C18 gene10661 0.78129 1.11 down Mm.183137 Krt2-1 100685_at M10937 keratin complex 2, basic, gene 110662 0.78136 1.17 up Mm.4211 Slc8a1 99525_at U70033 solute carrier family 8 (sodium/calcium exchanger), member 110663 0.78140 1.20 down Mm.656 Rrm1 161731_at AV269117 ribonucleotide reductase M110664 0.78146 1.07 down Mm.3122 Ltbr 97980_at L38423 lymphotoxin B receptor10665 0.78177 1.09 up Mm.25263 2700029M09Rik 94360_at AA672650 RIKEN cDNA 2700029M09 gene10666 0.78231 1.13 up Mm.7089 Ndn 101059_at D76440 necdin10667 0.78236 1.07 down Mm.3990 Skd3 160460_at AI837887 suppressor of K+ transport defect 310668 0.78281 1.12 down Mm.15691 Abcg1 160612_at Z48745 ATP-binding cassette, sub-family G (WHITE), member 110669 0.78304 1.06 up Mm.22252 4432405K22Rik 103471_at AI194333 RIKEN cDNA 4432405K22 gene10670 0.78307 1.11 up Mm.30290 Capn6 97943_at AI747133 calpain 610671 0.78322 1.15 up Mm.4298 En2 98338_at Y00203 engrailed 210672 0.78325 1.05 up Mm.10818 Stx7 160064_at AF056323 syntaxin 710673 0.78334 1.08 up Mm.44706 Mm.44706 99987_at AW050056 ESTs, Weakly similar to KR2 MOUSE MKR2 PROTEIN [M.musculus]10674 0.78344 1.11 up Mm.3534 Cryz 98131_at D78646 crystallin, zeta10675 0.78352 1.13 down Mm.6257 Slc1a6 99845_at D83262 solute carrier family 1, member 610676 0.78355 1.14 down Mm.206798 Tnp2 101534_at M60254 transition protein 210677 0.78356 1.16 up Mm.4375 Smstr2 98350_at AF008914 somatostatin receptor 210678 0.78362 1.07 down Mm.3402 Cebpg 92195_at AB012273 CCAAT/enhancer binding protein (C/EBP), gamma10679 0.78366 1.17 down Mm.1337 Cmkbr4 94696_at U15208 chemokine (C-C) receptor 410680 0.78367 1.06 down Mm.353 Atp5j 98128_at U77128 ATP synthase, H+ transporting, mitochondrial F0 complex subunit F10681 0.78369 1.03 up Mm.116 H2-Oa 95158_at AF100956 histocompatibility 2, O region alpha locus10682 0.78397 1.05 up Mm.20878 Wiz 103807_at AB012265 widely-interspaced zinc finger motifs10683 0.78400 1.24 down Mm.5009 Smy 161053_at X05260 spermiogenesis gene10684 0.78457 1.05 down Mm.197516 Rab4b 99505_at AI844664 RAB4B, member RAS oncogene family10685 0.78467 1.12 up Mm.4652 Ephb2 98771_at L25890 Eph receptor B210686 0.78469 1.12 up Mm.21306 Mmp24 160665_at AB021226 matrix metalloproteinase 2410687 0.78494 1.12 up Mm.4564 Sycp1 92692_at D88539 synaptonemal complex protein 110688 0.78506 1.15 up Mm.5263 1500032A09Rik 93155_at AI847069 RIKEN cDNA 1500032A09 gene10689 0.78509 1.10 up Mm.213565 H2-D 101886_f_at X52490 histocompatibility 2, D region10690 0.78510 1.06 up Mm.119162 Elavl1 94001_at U65735 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)10691 0.78533 1.09 up Mm.90071 2810432D09Rik 102194_at AW122332 RIKEN cDNA 2810432D09 gene10692 0.78535 1.10 down Mm.1442 Bdnf 102727_at X55573 brain derived neurotrophic factor10693 0.78549 1.07 up Mm.214944 D19435 99954_at AW046474 EST D1943510694 0.78558 1.12 up Mm.103593 Dkk2 161117_at AJ243963 dickkopf 210695 0.78558 1.11 down Mm.3959 Nell2 92358_at U59230 nel-like 2 homolog (chicken)10696 0.78562 1.14 down Mm.28188 Gcs1 161268_f_at AV318100 glucosidase 110697 0.78564 1.14 down Mm.3395 1110003B01Rik 98413_at AI849367 RIKEN cDNA 1110003B01 gene10698 0.78579 1.16 up Mm.56918 G6pd2 101293_at Z84471 glucose-6-phosphate dehydrogenase 210699 0.78591 1.12 up Mm.19154 Sucla2 93502_r_at AF058955 succinate-Coenzyme A ligase, ADP-forming, beta subunit10700 0.78593 1.08 up Mm.6724 Mm.6724 93448_at AA798076 Mus musculus, clone MGC:27690 IMAGE:4921222, mRNA, complete cds10701 0.78604 1.07 up Mm.193688 2700059D21Rik 93768_f_at AW124052 RIKEN cDNA 2700059D21 gene10702 0.78605 1.12 down Mm.22374 Gnpi 100565_at AW123396 glucosamine-6-phosphate deaminase10703 0.78612 1.04 down Mm.218851 Eif2s3x 94252_at AJ006587 eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked10704 0.78612 1.14 down Mm.41038 Mm.41038 162310_r_at AV050109 ESTs, Weakly similar to ZINC FINGER PROTEIN MLZ-4 [M.musculus]10705 0.78615 1.05 up Mm.4363 Tial1 99947_at U55861 Tial1 cytotoxic granule-associated RNA binding protein-like 110706 0.78639 1.17 up Mm.362 Lipc 98962_at X58426 lipase, hepatic10707 0.78643 1.13 up Mm.5049 Dvl3 101171_at U41285 dishevelled 3, dsh homolog (Drosophila)10708 0.78665 1.05 down Mm.21981 AI327276 94048_at AW120683 expressed sequence AI32727610709 0.78672 1.06 down Mm.7046 Ppgb 101055_at J05261 protective protein for beta-galactosidase10710 0.78691 1.05 down Mm.4524 Ldb1 160498_at U69270 LIM domain binding 1Page 119 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description10711 0.78692 1.20 up Mm.46801 Mm.46801 101319_f_at L28060 M.musculus mRNA (2F7) for IgA V-D-J-heavy chain10712 0.78695 1.04 down Mm.28270 Cdc5l 97846_at AI848968 cell division cycle 5-like (S. pombe)10713 0.78704 1.06 up Mm.6818 Itgb1bp1 100990_g_at AJ001373 integrin beta 1 binding protein 110714 0.78716 1.13 up Mm.20940 Casp14 103837_at AF092997 caspase 1410715 0.78721 1.16 down Mm.13451 2010305L05Rik 160986_r_at AA690434 RIKEN cDNA 2010305L05 gene10716 0.78761 1.19 up Mm.12604 Sirt1 92333_at AI849827 sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisi10717 0.78773 1.17 up Mm.24980 Mm.24980 95869_at C78041 EST10718 0.78774 1.15 up Mm.8509 Nr1i2 93696_at AF031814 nuclear receptor subfamily 1, group I, member 210719 0.78784 1.08 up Mm.5856 Nyren18-pending 161580_f_at AV314820 NY-REN-18 antigen10720 0.78801 1.09 up Mm.214976 Slc35a2 93558_at AB027147 solute carrier family 35 (UDP-galactose transporter), member 210721 0.78809 1.16 up Mm.157648 5730403B10Rik 100586_i_at AI843959 RIKEN cDNA 5730403B10 gene10722 0.78810 1.07 up Mm.182875 1190005P08Rik 104332_at AI842242 RIKEN cDNA 1190005P08 gene10723 0.78832 1.07 up Mm.28921 Cldn3 162315_f_at AV057837 claudin 310724 0.78844 1.13 up Mm.5349 1700018F16Rik 161358_r_at AV209030 RIKEN cDNA 1700018F16 gene10725 0.78855 1.05 down Mm.76247 Mm.76247 96731_at AA615100 EST10726 0.78857 1.05 down Mm.2467 Zrf2 104738_at D63784 zuotin related factor 210727 0.78862 1.13 up Mm.200918 AA409336 161600_r_at AV300608 expressed sequence AA40933610728 0.78886 1.11 down Mm.23758 1110008P04Rik 160703_at AW120644 RIKEN cDNA 1110008P04 gene10729 0.78893 1.05 down Mm.87773 Gpam 101867_at U11680 glycerol-3-phosphate acyltransferase, mitochondrial10730 0.78901 1.07 down Mm.10987 Limd1 160066_at AW123097 LIM domains containing 110731 0.78916 1.10 up Mm.153755 Pik3cd 92390_at U86587 phosphatidylinositol 3-kinase catalytic delta polypeptide10732 0.78918 1.06 up Mm.28920 D6Ertd365e 104418_at AA796868 DNA segment, Chr 6, ERATO Doi 365, expressed10733 0.78918 1.17 up Mm.6393 Dfy 93412_at AF016697 Duffy blood group10734 0.78927 1.09 up Mm.4052 AU040608 92386_at AI835016 expressed sequence AU04060810735 0.78929 1.15 up Mm.219659 Hist2 102558_at U62673 histone gene complex 210736 0.78932 1.08 down Mm.28955 4930570C03Rik 94504_at AI838655 RIKEN cDNA 4930570C03 gene10737 0.78943 1.16 down Mm.57242 Pax5 99809_at X55781 paired box gene 510738 0.78943 1.05 up Mm.27210 G6pdx 94966_at Z11911 glucose-6-phosphate dehydrogenase X-linked10739 0.78953 1.04 down Mm.2651 Req 96073_at U10435 requiem10740 0.78964 1.12 down Mm.200528 Hpic53 96043_at L43371 hydrogen peroxide inducible protein 5310741 0.78987 1.10 up Mm.68933 Mapk9 101362_at AB005664 mitogen activated protein kinase 910742 0.78997 1.06 down Mm.22613 2510027D20Rik 103512_at AW120816 RIKEN cDNA 2510027D20 gene10743 0.79001 1.12 up Mm.44235 Foxq1 92658_at AF010405 forkhead box Q110744 0.79019 1.13 up Mm.5202 6330406L22Rik 100511_at AI154249 RIKEN cDNA 6330406L22 gene10745 0.79037 1.11 up Mm.22242 AW112037 104282_at AW122808 expressed sequence AW11203710746 0.79076 1.06 up Mm.138544 Igk-V4 99624_at AW125517 immunoglobulin kappa chain variable 4 (V4)10747 0.79083 1.19 up Mm.6575 Cyp24 162070_r_at AV279051 cytochrome P450, 2410748 0.79107 1.06 down Mm.29835 AA617263 97395_at AW122465 expressed sequence AA61726310749 0.79124 1.05 up Mm.90410 D18Wsu98e 96113_at AI846519 DNA segment, Chr 18, Wayne State University 98, expressed10750 0.79126 1.05 up Mm.31130 Mm.31130 104641_f_at AI643393 ESTs, Moderately similar to VIS3 MOUSE VISININ-LIKE PROTEIN 3 [M.mus10751 0.79145 1.08 down Mm.153797 Bcl2 98868_at L31532 B-cell leukemia/lymphoma 210752 0.79151 1.14 up Mm.28479 Lag 97909_at AI838080 leukemia-associated gene10753 0.79162 1.10 up Mm.27447 Akr1c13 95015_at AB027125 aldo-keto reductase family 1, member C1310754 0.79168 1.16 down Mm.25575 Matr3 96013_r_at AI835367 matrin 310755 0.79172 1.12 up Mm.1641 Car4 103046_at U37091 carbonic anhydrase 410756 0.79180 1.03 up Mm.757 Arha2 101113_at AI846668 ras homolog A210757 0.79181 1.09 up Mm.4804 tub 98805_at U54643 tubby10758 0.79185 1.11 down Mm.4276 Kcnj6 92523_at U51126 potassium inwardly-rectifying channel, subfamily J, member 610759 0.79198 1.18 down Mm.133904 Mm.133904 162103_i_at AV291496 EST10760 0.79213 1.13 up Mm.103638 Tle4 102959_at U61363 transducin-like enhancer of split 4, homolog of Drosophila E(spl)10761 0.79222 1.11 up Mm.28480 Fkbp3 97548_at AI155120 FK506 binding protein 3 (25kD)10762 0.79233 1.11 up Mm.2229 Eya2 104292_at U81603 eyes absent 2 homolog (Drosophila)10763 0.79249 1.16 up Mm.6523 S100a13 161862_i_at AV067606 S100 calcium binding protein A1310764 0.79257 1.08 down Mm.4839 Acvrl1 100449_g_at Z31664 activin A receptor, type II-like 110765 0.79271 1.10 down Mm.1687 2810429C13Rik 103071_at AI843655 RIKEN cDNA 2810429C13 gene10766 0.79309 1.17 up Mm.132309 Kcnd2 98364_at AF107780 potassium voltage-gated channel, Shal-related family, member 210767 0.79318 1.18 up Mm.19353 LOC56304 99369_f_at AF029261 recombinant antineuraminidase single chain Ig VH and VL domains10768 0.79329 1.07 up Mm.28972 T25534 96751_at AI842674 expressed sequence T2553410769 0.79330 1.16 up Mm.4987 Ibsp 100476_at L20232 integrin binding sialoprotein10770 0.79336 1.08 down Mm.41755 Dapk2 99506_at AB018002 death-associated kinase 210771 0.79341 1.13 up Mm.4323 Mtap1b 99928_at X51396 microtubule-associated protein 1 B10772 0.79343 1.08 up Mm.3369 AW544981 97116_at AW123210 expressed sequence AW54498110773 0.79351 1.14 up Mm.40120 MLN51 98448_at AW060861 MLN51 protein10774 0.79356 1.08 down Mm.29266 Lmo2 93666_at M64360 LIM only 210775 0.79361 1.09 down Mm.365 Abcd1 98969_at Z33637 ATP-binding cassette, sub-family D (ALD), member 110776 0.79387 1.16 down Mm.5177 Kcnq1 99322_at U70068 potassium voltage-gated channel, subfamily Q, member 110777 0.79399 1.07 down Mm.28450 D4Wsu24e 104263_at AA914734 DNA segment, Chr 4, Wayne State University 24, expressed10778 0.79402 1.06 up Mm.192448 2700088M22Rik 104060_at AI845977 RIKEN cDNA 2700088M22 gene10779 0.79425 1.11 up Mm.25246 Spink4 94358_at Y11505 serine protease inhibitor, Kazal type 410780 0.79470 1.07 up Mm.2034 Nfh 103234_at M35131 neurofilament, heavy polypeptide10781 0.79479 1.10 down Mm.15568 Pou2f1 102893_at X68363 POU domain, class 2, transcription factor 110782 0.79484 1.18 up Mm.24001 Mef2c 104591_g_at L13171 myocyte enhancer factor 2C10783 0.79512 1.17 up Mm.4527 Cd3d 161863_r_at AV067753 CD3 antigen, delta polypeptide10784 0.79513 1.08 down Mm.21503 B3gnt1 161267_f_at AV315957 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 110785 0.79530 1.07 up Mm.24402 Gfpt2 103737_at AB016780 glutamine fructose-6-phosphate transaminase 210786 0.79539 1.11 down Mm.4596 Zfp97 98762_f_at L20450 zinc finger protein 9710787 0.79546 1.06 down Mm.24187 AI415282 94920_at AI854028 expressed sequence AI41528210788 0.79548 1.12 down Mm.1182 Mm.1182 102368_at AW121186 ESTs, Weakly similar to S12207 hypothetical protein [M.musculus]10789 0.79567 1.07 down Mm.30084 Np15 96887_at Y08702 nuclear protein 15.610790 0.79569 1.07 up Mm.218515 Mrpl9 102058_at AI845667 mitochondrial ribosomal protein L910791 0.79589 1.22 down Mm.3137 Ptgs2 104647_at M88242 prostaglandin-endoperoxide synthase 210792 0.79590 1.06 down Mm.21218 2010204I15Rik 93777_at AW046027 RIKEN cDNA 2010204I15 gene10793 0.79598 1.05 down Mm.12973 Cops7b 102765_at AF071317 COP9 (constitutive photomorphogenic) homolog, subunit 7b (Arabidopsis tha10794 0.79599 1.10 up Mm.3000 P2ry2 104479_at L14751 purinergic receptor P2Y, G-protein coupled 210795 0.79613 1.14 up Mm.22231 Sncg 104280_at AF017255 synuclein, gamma10796 0.79667 1.05 down Mm.2379 Asml3a-pending 94872_at Y08135 acid sphingomyelinase-like phosphodiesterase 3a10797 0.79668 1.06 up Mm.88850 Zirtl 96832_at AA606878 zinc-iron transporter-like10798 0.79695 1.09 up Mm.10600 Glud 92586_at X57024 glutamate dehydrogenase10799 0.79697 1.17 up Mm.1202 Myb 162411_f_at AV317290 myeloblastosis oncogene10800 0.79709 1.12 up Mm.20440 Htr4 95321_at Y09588 5 hydroxytryptamine (serotonin) receptor 4Page 120 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description10801 0.79720 1.12 up Mm.153202 3300001M08Rik 161676_at AV169462 RIKEN cDNA 3300001M08 gene10802 0.79733 1.05 down Mm.23997 Rmp-pending 104589_at AF091096 RPB5-mediating protein10803 0.79741 1.11 down Mm.28825 2310038G18Rik 160793_at AI851313 RIKEN cDNA 2310038G18 gene10804 0.79749 1.15 down Mm.684 Ctsc 161251_f_at AV316954 cathepsin C10805 0.79783 1.09 down Mm.1568 Grn 93066_at D16195 granulin10806 0.79793 1.08 down Mm.24516 Mm.24516 103752_r_at AW227545 ESTs10807 0.79795 1.17 up Mm.24245 Tcea2 162247_r_at AV333838 transcription elongation factor A (SII), 210808 0.79798 1.06 down Mm.35779 1300004C11Rik 98154_at AW050133 RIKEN cDNA 1300004C11 gene10809 0.79802 1.12 up Mm.21507 1810020N21Rik 161406_at AV280754 RIKEN cDNA 1810020N21 gene10810 0.79815 1.12 down Mm.4592 Cish 162383_r_at AV248632 cytokine inducible SH2-containing protein10811 0.79819 1.08 up Mm.11311 2310057D15Rik 160067_at AW125329 RIKEN cDNA 2310057D15 gene10812 0.79839 1.09 down Mm.18561 Cyhr1 103466_at AA790056 cysteine and histidine rich 110813 0.79852 1.13 up Mm.2987 Igb 161012_at J03857 immunoglobulin-associated beta10814 0.79873 1.16 up Mm.30025 AI114908 96846_at AI226846 expressed sequence AI11490810815 0.79890 1.17 down Mm.24216 Rbbp9 162230_r_at AV128327 retinoblastoma binding protein 910816 0.79898 1.10 down Mm.28544 1600012H06Rik 98891_at AW011716 RIKEN cDNA 1600012H06 gene10817 0.79916 1.09 down Mm.30006 1500035H01Rik 161949_at AV215339 RIKEN cDNA 1500035H01 gene10818 0.79917 1.12 down Mm.4756 Lepr 100431_at U42467 leptin receptor10819 0.79925 1.06 up Mm.2213 Ercc5 103483_at U40796 excision repair cross-complementing rodent repair deficiency,complementati10820 0.79948 1.17 up Mm.5236 Rgds 161778_i_at AV345884 ral guanine nucleotide dissociation stimulator10821 0.79954 1.08 up Mm.43786 Cox7c 99661_r_at X52940 cytochrome c oxidase, subunit VIIc10822 0.79955 1.24 down Mm.5668 Mm.5668 101227_at C78037 ESTs10823 0.79962 1.23 up Mm.14102 Ifna11 100671_at M68944 interferon alpha family, gene 1110824 0.79967 1.15 down Mm.10692 Sprr2f 101761_f_at AJ005561 small proline-rich protein 2F10825 0.79975 1.07 down Mm.27395 0610025I19Rik 96670_at AI841295 RIKEN cDNA 0610025I19 gene10826 0.79994 1.05 up Mm.692 Api5 101035_at U35846 apoptosis inhibitory protein 510827 0.79998 1.10 up Mm.28949 D7Ertd304e 96561_at AI157475 DNA segment, Chr 7, ERATO Doi 304, expressed10828 0.80011 1.12 down Mm.6284 Siat4a 99847_at X73523 sialyltransferase 4A (beta-galactosidase alpha-2,3-sialytransferase)10829 0.80027 1.10 up Mm.189815 Mm.189815 161595_at AV292586 EST10830 0.80032 1.10 up Mm.5110 Ovgp1 100521_at D32137 oviductal glycoprotein 1, 120kD10831 0.80039 1.06 down Mm.22478 Smarcf1 104330_g_at AI842326 SWI/SNF related, matrix associated, actin dependent regulator of chromatin,10832 0.80049 1.04 down Mm.182772 Mtx2 160076_at AF053550 metaxin 210833 0.80050 1.14 up Mm.2661 Tk1 161150_at AV227393 thymidine kinase 110834 0.80060 1.08 down Mm.218310 Mm.218310 93907_f_at M17551 Murine (DBA/2) mRNA fragment for gag related peptide10835 0.80066 1.13 down Mm.2214 4-Sep 94079_at X61452 septin 410836 0.80067 1.10 down Mm.15510 Gzma 102995_s_at M13226 granzyme A10837 0.80078 1.05 up Mm.148877 Recc1 98335_at X72711 replication factor C, 140 kDa10838 0.80091 1.06 up Mm.2806 Xpc 95626_at U27398 xeroderma pigmentosum, complementation group C10839 0.80133 1.10 down Mm.35019 Mm.35019 92245_at AI642262 ESTs10840 0.80140 1.05 down Mm.42972 Ywhae 160485_r_at D87663 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,10841 0.80177 1.10 down Mm.154901 Mm.154901 101694_f_at W91649 ESTs10842 0.80179 1.14 down Mm.5162 4432411H13Rik 162361_at AV227938 RIKEN cDNA 4432411H13 gene10843 0.80252 1.08 down Mm.28393 Spr 97886_at AI530375 sepiapterin reductase10844 0.80267 1.12 up Mm.202745 4931433E08Rik 160191_at AW122058 RIKEN cDNA 4931433E08 gene10845 0.80286 1.09 up Mm.143689 Facl4 104017_at AB033887 fatty acid-Coenzyme A ligase, long chain 410846 0.80290 1.04 down Mm.21625 1500040F11Rik 93844_at AW061302 RIKEN cDNA 1500040F11 gene10847 0.80296 1.04 down Mm.27270 Dctn5 96636_at AI852649 dynactin 510848 0.80299 1.12 up Mm.2523 Myt1l 96496_g_at U86338 myelin transcription factor 1-like10849 0.80304 1.13 up Mm.6949 Mllt2h 93468_at AF074266 homolog of human MLLT2 unidentified gene10850 0.80314 1.07 up Mm.90115 Lypla1 97207_f_at AI875934 lysophospholipase 110851 0.80315 1.09 up Mm.6672 Batf 93444_at AF017021 basic leucine zipper transcription factor, ATF-like10852 0.80316 1.07 up Mm.27391 Mm.27391 160740_at AA615984 ESTs10853 0.80316 1.17 down Mm.51819 Arx 92186_at AB006103 aristaless related homeobox gene (Drosophila)10854 0.80328 1.04 up Mm.25345 2310003C10Rik 103947_at AW048038 RIKEN cDNA 2310003C10 gene10855 0.80334 1.10 down Mm.5088 Atm 101180_at U43678 ataxia telangiectasia mutated homolog (human)10856 0.80348 1.11 down Mm.57230 Neurod3 93230_at U63841 neurogenic differentiation 310857 0.80350 1.07 down Mm.43737 Csnk1a1 99650_at X90945 casein kinase 1, alpha 110858 0.80359 1.11 down Mm.6904 Fgfr3 162253_i_at AV336395 fibroblast growth factor receptor 310859 0.80420 1.06 up Mm.1740 Ltk 94791_s_at M90470 leukocyte tyrosine kinase10860 0.80427 1.10 down Mm.20285 Krt2-19 96782_at AA763244 keratin complex 2, basic, gene 1910861 0.80473 1.17 down Mm.24490 Mm.24490 95919_at AA408477 ESTs, Weakly similar to IGEB MOUSE IGE-BINDING PROTEIN [M.musculu10862 0.80478 1.13 down Mm.14774 Tead4 102868_g_at U51743 TEA domain family member 410863 0.80487 1.14 down Mm.188939 Hsd17b1 92557_at AF039299 hydroxysteroid 17-beta dehydrogenase 110864 0.80529 1.05 down Mm.42126 Gprk7 101007_at AI845732 G protein-coupled receptor kinase 710865 0.80551 1.14 up Mm.5978 D11Ertd326e 101611_at C80900 DNA segment, Chr 11, ERATO Doi 326, expressed10866 0.80553 1.07 up Mm.21772 Smarcd2 161965_r_at AV367494 SWI/SNF related, matrix associated, actin dependent regulator of chromatin,10867 0.80572 1.05 down Mm.13445 Oxct 92845_at AI843232 3-oxoacid CoA transferase10868 0.80579 1.12 down Mm.24058 Mm.24058 95891_at AI591977 ESTs10869 0.80616 1.06 up Mm.5053 Slc4a3 92987_at M28383 solute carrier family 4 (anion exchanger), member 310870 0.80630 1.12 down Mm.5363 Mm.5363 99346_at AA111141 ESTs, Weakly similar to NALS_HUMAN N-ACETYLLACTOSAMINE SYNTH10871 0.80636 1.11 up Mm.1349 Il1r2 102658_at X59769 interleukin 1 receptor, type II10872 0.80649 1.12 down Mm.197684 Kifc1 98471_f_at D49544 kinesin family member C110873 0.80649 1.12 up Mm.4635 Kif3a 161275_at AV324729 kinesin family member 3a10874 0.80668 1.04 down Mm.38994 2600001N01Rik 160455_s_at AW123786 RIKEN cDNA 2600001N01 gene10875 0.80668 1.15 up Mm.196590 Spi1-5 101574_f_at M75717 serine protease inhibitor 1-510876 0.80674 1.14 down Mm.2759 Agc1 104205_at L07049 aggrecan 110877 0.80740 1.16 down Mm.12869 U55872 99237_at U55872 cDNA sequence U5587210878 0.80742 1.11 down Mm.97865 Mm.97865 162199_r_at AV373223 EST, Moderately similar to MAST CELL PROTEASE 8 PRECURSOR [M.mu10879 0.80743 1.12 down Mm.4610 Upp 100030_at D44464 uridine phosphorylase10880 0.80756 1.14 up Mm.29696 2310022K01Rik 97371_at AW120599 RIKEN cDNA 2310022K01 gene10881 0.80779 1.15 up Mm.10727 Atp6b2 92597_s_at U13838 ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa10882 0.80779 1.07 up Mm.3035 3110006P09Rik 97462_at AI847584 RIKEN cDNA 3110006P09 gene10883 0.80782 1.07 down Mm.4771 Nfia 92893_at D90173 nuclear factor I/A10884 0.80791 1.09 down Mm.3254 Mm.3254 161562_f_at AV266764 ESTs, Weakly similar to zinc finger protein 105 [M.musculus]10885 0.80803 1.10 up Mm.22622 Wnt5b 103513_at M89799 wingless-related MMTV integration site 5B10886 0.80829 1.07 up Mm.3758 Crkas 98990_at U28151 v-crk-associated tyrosine kinase substrate10887 0.80850 1.10 up 101340_at AE00066510888 0.80851 1.18 up Mm.1668 Fmo5 160088_at U90535 flavin containing monooxygenase 510889 0.80854 1.05 up Mm.29836 Pip5k1c 94119_at AB006916 phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma10890 0.80867 1.13 up Mm.46746 2010306G19Rik 93853_at AA763918 RIKEN cDNA 2010306G19 genePage 121 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description10891 0.80869 1.05 up Mm.153963 Cd8b 94000_at X07698 CD8 antigen, beta chain10892 0.80881 1.09 up Mm.25057 Tktl1 161110_at AI156310 transketolase-like 110893 0.80886 1.13 up Mm.46514 Mylc2a 100403_at AA839903 myosin light chain, regulatory A10894 0.80900 1.08 up Mm.1568 Grn 161546_r_at AV242495 granulin10895 0.80908 1.11 up Mm.199223 AA408140 95719_at AW061157 expressed sequence AA40814010896 0.80947 1.14 up Mm.8010 Hcn1 99902_at AJ225123 hyperpolarization-activated, cyclic nucleotide-gated K+ 110897 0.80950 1.09 up Mm.2013 5830406C15Rik 103223_at AW120767 RIKEN cDNA 5830406C15 gene10898 0.80982 1.08 up Mm.28513 Sp3 96192_at AF062567 trans-acting transcription factor 310899 0.80987 1.10 down Mm.7 Vim 162379_r_at AV245272 vimentin10900 0.81004 1.15 down Mm.22280 Mm.22280 103495_at AA739246 ESTs10901 0.81021 1.12 up Mm.31512 Rnf2 93164_at Y12783 ring finger protein 210902 0.81088 1.03 down Mm.21399 2010016I08Rik 93795_at AW124626 RIKEN cDNA 2010016I08 gene10903 0.81093 1.09 down Mm.178947 Becn1 161227_r_at AV260411 beclin 1 (coiled-coil, myosin-like BCL2-interacting protein)10904 0.81097 1.09 up Mm.203921 AI850305 162225_f_at AV120116 expressed sequence AI85030510905 0.81101 1.14 up Mm.30375 Klk5 104495_f_at Y00500 kallikrein 510906 0.81103 1.09 up Mm.7198 Mkrn1 101068_at AA656621 makorin, ring finger protein, 110907 0.81108 1.19 up Mm.31704 C80208 97095_at AI428843 expressed sequence C8020810908 0.81160 1.11 up Mm.25620 Dntt 103962_at X04123 deoxynucleotidyltransferase, terminal10909 0.81166 1.05 down Mm.2945 Cappb1 95142_s_at U10407 capping protein beta 110910 0.81172 1.08 up Mm.22 1600014E20Rik 161097_at AI448024 RIKEN cDNA 1600014E20 gene10911 0.81199 1.12 up Mm.3072 Sipa1 97963_at D11374 signal-induced proliferation associated gene 110912 0.81228 1.04 down Mm.3154 Mm.3154 104651_at AI839611 ESTs, Highly similar to SNXE_HUMAN SORTING NEXIN 14 [H.sapiens]10913 0.81237 1.11 up Mm.98082 E130103E02Rik 104186_at AA739263 RIKEN cDNA E130103E02 gene10914 0.81247 1.08 up Mm.200199 AI481320 103552_at AW046470 expressed sequence AI48132010915 0.81255 1.08 up Mm.24967 D8Ertd67e 95863_at C77756 DNA segment, Chr 8, ERATO Doi 67, expressed10916 0.81268 1.06 up Mm.18739 C130020J04Rik 93342_at AI852665 RIKEN cDNA C130020J04 gene10917 0.81276 1.15 down Mm.938 Foxa2 93950_at L10409 forkhead box A210918 0.81289 1.10 up Mm.1012 Krt1-19 92550_at M36120 keratin complex 1, acidic, gene 1910919 0.81290 1.14 down Mm.26654 1700007P10Rik 160729_f_at AI046575 RIKEN cDNA 1700007P10 gene10920 0.81292 1.08 up Mm.12848 Srp54 160073_i_at X16319 signal recognition particle 54 kDa10921 0.81327 1.10 up Mm.197523 Bach-pending 100539_at AI841279 brain acyl-CoA hydrolase10922 0.81380 1.12 up Mm.137912 9430077D24Rik 96924_at AI849719 RIKEN cDNA 9430077D24 gene10923 0.81387 1.14 down Mm.2965 Mm.2965 96567_at M36699 Mus musculus, Similar to rhodopsin (opsin 2, rod pigment) (retinitis pigmento10924 0.81389 1.05 down Mm.132544 0610009M14Rik 94229_at AW124489 RIKEN cDNA 0610009M14 gene10925 0.81394 1.14 up Mm.1532 Mm.1532 161953_at AV361852 Mus musculus, clone MGC:31332 IMAGE:4224574, mRNA, complete cds10926 0.81439 1.08 down Mm.57035 Itga3 104211_at D13867 integrin alpha 310927 0.81440 1.06 down Mm.27434 1810063B07Rik 95011_at AI853090 RIKEN cDNA 1810063B07 gene10928 0.81441 1.08 up Mm.2018 Cbfb 93546_s_at D14572 core binding factor beta10929 0.81448 1.07 up Mm.18824 Mm.18824 103411_at AI835098 ESTs, Weakly similar to T33457 hypothetical protein F36H12.3 - Caenorhab10930 0.81460 1.17 up Mm.193418 Spi1-2 101576_f_at M25529 serine protease inhibitor 1-210931 0.81510 1.07 up Mm.16366 Mtcp1 103043_at Z35294 mature T-cell proliferation 110932 0.81525 1.11 up 93856_at M5551210933 0.81535 1.05 down Mm.10623 AI480570 92589_at AI846545 expressed sequence AI48057010934 0.81554 1.06 down Mm.4235 Kitl 99577_at M57647 kit ligand10935 0.81579 1.07 down Mm.196520 Tcp1-rs1 101006_at M35797 t-complex protein 1, related sequence 110936 0.81582 1.07 down 92624_r_at U0918910937 0.81582 1.12 up Mm.4084 Ndst2 161336_r_at AV121174 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 210938 0.81597 1.09 up Mm.24993 D7Ertd183e 95872_at C78535 DNA segment, Chr 7, ERATO Doi 183, expressed10939 0.81599 1.15 up Mm.171277 2510010B09Rik 93186_at AI426987 RIKEN cDNA 2510010B09 gene10940 0.81609 1.22 down Mm.7486 Bmp2 102559_at L25602 bone morphogenetic protein 210941 0.81631 1.03 down Mm.196442 Supt4h2 95796_g_at U96810 suppressor of Ty 4 homolog 2 (S. cerevisiae)10942 0.81658 1.13 up Mm.25149 Usp14 162059_r_at AV271750 ubiquitin specific protease 1410943 0.81665 1.07 down Mm.147946 Mybbp1a 161287_f_at AV025391 MYB binding protein (P160) 1a10944 0.81681 1.09 up Mm.6680 Catnd2 99856_r_at AI852919 catenin delta 210945 0.81710 1.10 down Mm.8235 Stk10 93680_at D89728 serine/threonine kinase 1010946 0.81713 1.08 down Mm.18300 Slc3a1 94957_at AW121154 solute carrier family 3, member 110947 0.81759 1.09 down Mm.1243 Rxrb 102398_at D21831 retinoid X receptor beta10948 0.81780 1.11 down Mm.26166 Acp1 93219_at Y17343 acid phosphatase 1, soluble10949 0.81802 1.05 down Mm.17461 Stk16 93272_at AF062076 serine/threonine kinase 1610950 0.81823 1.11 up Mm.1237 Pmp22 102395_at Z38110 peripheral myelin protein, 22 kDa10951 0.81825 1.06 up Mm.4822 Hoxb7 92914_at M18400 homeo box B710952 0.81826 1.11 up Mm.24982 C78111 103795_f_at AA986114 expressed sequence C7811110953 0.81839 1.12 up Mm.41985 Hnf4g 101704_at AJ242626 hepatocyte nuclear factor 4, gamma10954 0.81840 1.07 up Mm.4653 TgN737Rpw 162392_r_at AV266216 transgene insert site 737, insertional mutation, polycystic kidney disease10955 0.81843 1.12 up Mm.29835 AA617263 162235_f_at AV327145 expressed sequence AA61726310956 0.81851 1.15 down Mm.12956 Hcn2 94194_s_at AJ225122 hyperpolarization-activated, cyclic nucleotide-gated K+ 210957 0.81885 1.11 down Mm.10152 Rnaseh1 102031_at AF048993 ribonuclease H110958 0.81893 1.05 up Mm.7861 Hnrpdl 96084_at AB017020 heterogeneous nuclear ribonucleoprotein D-like10959 0.81932 1.06 down Mm.20915 Top3b 103823_at AB013603 topoisomerase (DNA) III beta10960 0.81945 1.06 down Mm.2626 Aes 160215_at L12140 amino-terminal enhancer of split10961 0.81947 1.08 down Mm.11285 AI836109 102349_at AI842849 expressed sequence AI83610910962 0.81953 1.06 down Mm.1571 2610005L07Rik 103010_at AW048174 RIKEN cDNA 2610005L07 gene10963 0.81965 1.04 up Mm.23998 Mm.23998 94895_at AW122948 Mus musculus, clone MGC:11691 IMAGE:3962417, mRNA, complete cds10964 0.81966 1.18 down Mm.1763 Msx2 102956_at X59252 homeo box, msh-like 210965 0.81967 1.08 down Mm.2653 Epor 103997_at X53081 erythropoietin receptor10966 0.81981 1.08 up Mm.28038 4831429J16Rik 97295_at AW122331 RIKEN cDNA 4831429J16 gene10967 0.81998 1.10 up Mm.1060 Cd28 102237_at M34563 CD28 antigen10968 0.82010 1.06 up Mm.29809 2410015J15Rik 161542_r_at AV240248 RIKEN cDNA 2410015J15 gene10969 0.82011 1.05 up Mm.24338 BB101783 104632_at AI840078 expressed sequence BB10178310970 0.82021 1.08 down Mm.176854 Mm.176854 161120_r_at AV132572 ESTs10971 0.82037 1.08 down Mm.46005 2600011C06Rik 97816_at AI848222 RIKEN cDNA 2600011C06 gene10972 0.82043 1.06 down Mm.27135 Abcf3 96619_at AW107934 ATP-binding cassette, sub-family F (GCN20), member 310973 0.82049 1.11 down Mm.57098 Amh 101765_at X63240 anti-Mullerian hormone10974 0.82057 1.10 up Mm.2878 Sox18 104408_s_at L35032 SRY-box containing gene 1810975 0.82058 1.09 up Mm.1292 Th 100690_at M69200 tyrosine hydroxylase10976 0.82058 1.17 up Mm.28362 AI326478 93904_f_at AF059706 expressed sequence AI32647810977 0.82066 1.11 down Mm.18470 Stk22a 103360_at U01840 serine/threonine kinase 22A (spermiogenesis associated)10978 0.82101 1.08 up Mm.28912 Pex13 94491_at AW123194 peroxisomal biogenesis factor 1310979 0.82137 1.12 up Mm.29394 2410008J01Rik 96827_at AW061272 RIKEN cDNA 2410008J01 gene10980 0.82138 1.14 up Mm.28398 Fabp2 97889_at M65034 fatty acid binding protein 2, in<strong>test</strong>inalPage 122 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description10981 0.82153 1.08 up Mm.10001 Hccs 160573_at AA645537 holocytochrome c synthetase10982 0.82171 1.12 up Mm.1845 Pcx 162288_f_at AV374281 pyruvate decarboxylase10983 0.82183 1.04 up Mm.204670 2810425A04Rik 97939_at AW125079 RIKEN cDNA 2810425A04 gene10984 0.82197 1.14 up Mm.45207 Magel2 92681_at AJ243608 melanoma antigen, family L, 210985 0.82208 1.11 up Mm.4640 Lrrn1 161045_at D45913 leucine rich repeat protein 1, neuronal10986 0.82213 1.08 down Mm.56560 Mm.56560 161248_r_at AV313356 EST10987 0.82219 1.08 down Mm.33669 Cldn1 160415_at AI604314 claudin 110988 0.82232 1.06 down Mm.18565 Plp2 93323_at AB031292 proteolipid protein 210989 0.82242 1.12 up Mm.39292 Dnm2 162484_r_at AV120644 dynamin 210990 0.82242 1.09 up Mm.57084 Sprr2j 101755_f_at AJ005568 small proline-rich protein 2J10991 0.82250 1.10 down Mm.33819 Trpm7 97136_at AA571388 transient receptor potential cation channel, subfamily M, member 710992 0.82290 1.08 up Mm.29901 1500034J01Rik 97404_at AW048244 RIKEN cDNA 1500034J01 gene10993 0.82305 1.10 up Mm.2251 Plxn2 95368_at D86949 plexin 210994 0.82323 1.11 up Mm.4303 Ezh2 99917_at U52951 enhancer of zeste homolog 2 (Drosophila)10995 0.82323 1.15 down Mm.16893 D7Ertd128e 94785_at C80266 DNA segment, Chr 7, ERATO Doi 128, expressed10996 0.82336 1.18 down Mm.15711 Cnp1 93072_at D38642 cyclic nucleotide phosphodiesterase 110997 0.82342 1.07 up Mm.56895 D17H6S56E-3 97894_at AF109905 DNA segment, Chr 17, human D6S56E 310998 0.82343 1.08 up Mm.2661 Tk1 96081_at X60980 thymidine kinase 110999 0.82347 1.06 up Mm.182650 2610209M04Rik 99651_at AI849549 RIKEN cDNA 2610209M04 gene11000 0.82352 1.11 up Mm.4712 Itgb1 100123_f_at X15202 integrin beta 1 (fibronectin receptor beta)11001 0.82381 1.09 down Mm.173718 AA410158 94235_at AW050034 expressed sequence AA41015811002 0.82397 1.05 up Mm.41890 2010315L10Rik 99188_at AA615161 RIKEN cDNA 2010315L10 gene11003 0.82459 1.08 down Mm.35664 D2Ertd97e 92261_at AW047467 DNA segment, Chr 2, ERATO Doi 97, expressed11004 0.82469 1.06 up Mm.38172 Mapk7 99000_at AB019373 mitogen-activated protein kinase 711005 0.82480 1.11 down Mm.20403 Mm.20403 95315_at AI325915 ESTs, Moderately similar to zinc finger protein 30 [M.musculus]11006 0.82484 1.11 down Mm.31304 1700112N14Rik 101674_at AA690149 RIKEN cDNA 1700112N14 gene11007 0.82486 1.12 up Mm.8024 Figla 94627_at U91840 factor in the germline alpha11008 0.82520 1.07 down Mm.3255 Pcsk7 98022_at U48830 proprotein convertase subtilisin/kexin type 711009 0.82534 1.15 down Mm.12884 Mcp 94178_at AB010919 membrane cofactor protein11010 0.82542 1.08 down Mm.3781 Piga 92304_at D31863 phosphatidylinositol glycan, class A11011 0.82544 1.07 down Mm.202358 Mm.202358 160624_at AW122304 Mus musculus, clone IMAGE:4236601, mRNA11012 0.82559 1.11 down Mm.37806 C78513 97693_at C78513 EST C7851311013 0.82562 1.16 up Mm.4283 Bop1 161599_i_at AV298501 block of proliferation 111014 0.82564 1.08 up Mm.25227 4930429H24Rik 96494_at AA691628 RIKEN cDNA 4930429H24 gene11015 0.82566 1.05 up Mm.2621 Aldh2 161997_f_at AV329607 aldehyde dehydrogenase 2, mitochondrial11016 0.82568 1.08 down Mm.7414 Nsg1 161463_f_at AV347030 neuron specific gene family member 111017 0.82583 1.06 down Mm.28023 Mtch2-pending 160262_at AI839901 mitochondrial carrier homolog 211018 0.82604 1.12 up Mm.2530 Bapx1 100714_at U87957 bagpipe homeobox gene 1 homolog (Drosophila)11019 0.82606 1.11 down Mm.4432 Hoxd3 98367_at X73572 homeo box D311020 0.82617 1.07 up 101204_at T2564511021 0.82620 1.04 down Mm.665 Psmc5 160534_at Z54219 protease (prosome, macropain) 26S subunit, ATPase 511022 0.82622 1.11 up 93899_at AJ00065411023 0.82622 1.05 up Mm.1139 Rps6 101577_at Z54209 ribosomal protein S611024 0.82624 1.10 down Mm.219659 Hist2 94805_f_at M33988 histone gene complex 211025 0.82630 1.14 up Mm.179304 Ubc6p-pending 93524_i_at AI839376 ubiquitin conjugating enzyme 611026 0.82633 1.17 down Mm.200858 2410129E14Rik 161614_r_at AV351758 RIKEN cDNA 2410129E14 gene11027 0.82635 1.07 down Mm.218637 Cd2ap 103281_at AF077003 CD2-associated protein11028 0.82643 1.07 down Mm.15962 Parg 160949_at AI848924 poly (ADP-ribose) glycohydrolase11029 0.82647 1.05 up Mm.26680 Mm.26680 96086_at AW122530 Mus musculus, clone MGC:37030 IMAGE:4949809, mRNA, complete cds11030 0.82659 1.11 up Mm.384 Il9r 95275_at M84746 interleukin 9 receptor11031 0.82664 1.08 down Mm.24343 Mm.24343 103733_at AI006698 ESTs11032 0.82687 1.12 down Mm.206796 Spi16 100739_at U96702 serine protease inhibitor 1611033 0.82703 1.15 down Mm.88852 Dmrt1 100374_at AL133300 doublesex and mab-3 related transcription factor 111034 0.82706 1.08 down Mm.89191 Ptprd 93896_at D13903 protein tyrosine phosphatase, receptor type, D11035 0.82711 1.10 up Mm.3609 AA408306 92272_at AI060709 expressed sequence AA40830611036 0.82730 1.10 down Mm.10696 Nrg1 97581_at AF059485 neuregulin 111037 0.82742 1.07 down Mm.218521 Mm.218521 104106_at AI837830 Mus musculus, clone MGC:28589 IMAGE:4212192, mRNA, complete cds11038 0.82744 1.04 up Mm.2284 Hexa 94840_at U05837 hexosaminidase A11039 0.82753 1.07 up Mm.4694 Hoxa9 92745_at AB005458 homeo box A911040 0.82757 1.11 up Mm.32187 Mm.32187 92761_at AI448164 ESTs, Weakly similar to TYROSINE-PROTEIN KINASE JAK3 [M.musculus]11041 0.82759 1.10 up Mm.28499 AI413631 160297_at AW121431 expressed sequence AI41363111042 0.82820 1.04 down Mm.41977 Taf1c 92456_at Y09974 TATA box binding protein (Tbp)-associated factor, RNA polymerase I, C11043 0.82830 1.06 up Mm.1782 Rcn2 93281_at AF049125 reticulocalbin 211044 0.82858 1.14 up Mm.14774 Tead4 102867_at U51743 TEA domain family member 411045 0.82860 1.07 down Mm.8004 Gabrb3 99897_at U14420 gamma-aminobutyric acid (GABA-A) receptor, subunit beta 311046 0.82864 1.17 up Mm.89201 Zfp179 100383_at AB013097 zinc finger protein 17911047 0.82868 1.08 up Mm.23692 Csnk2a1-rs4 103441_at AI194248 casein kinase II, alpha 1 related sequence 411048 0.82886 1.12 up Mm.2542 Has1 100716_at D82964 hyaluronan synthase111049 0.82899 1.06 up Mm.10509 Mm.10509 94110_f_at D10627 Mus musculus mRNA for zinc finger protein, partial cds11050 0.82900 1.06 up Mm.22485 2610311I19Rik 103726_at AI842264 RIKEN cDNA 2610311I19 gene11051 0.82909 1.06 up Mm.196110 Hba-a1 101703_at V00716 hemoglobin alpha, adult chain 111052 0.82917 1.14 down Mm.80 Afp 101494_at V00743 alpha fetoprotein11053 0.82925 1.12 up Mm.3118 Actr1a 160407_at AB010297 actin-related protein 1 homolog A (yeast)11054 0.82939 1.09 down Mm.7206 Slc27a1 93486_at U15976 solute carrier family 27 (fatty acid transporter), member 111055 0.82956 1.05 down Mm.4368 Gclc 99649_at U85414 glutamate-cysteine ligase, catalytic subunit11056 0.82957 1.07 up Mm.123510 B3galt2 92341_at AF029791 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 211057 0.82972 1.09 down Mm.87216 Rabggta 93851_at AI272518 Rab geranylgeranyl transferase, a subunit11058 0.82979 1.06 down Mm.57148 Galr3 101806_at AF042783 galanin receptor 311059 0.82991 1.08 up Mm.2197 Ambp 94045_at X68680 alpha 1 microglobulin/bikunin11060 0.83001 1.13 up Mm.7150 1810030J14Rik 101386_at AA690372 RIKEN cDNA 1810030J14 gene11061 0.83025 1.05 down Mm.193413 Mm.193413 97921_at AI846279 Mus musculus, clone IMAGE:3494258, mRNA, partial cds11062 0.83026 1.07 down Mm.181661 Setdb1 102771_at AF091628 SET domain, bifurcated 111063 0.83026 1.08 down Mm.27293 4833420K19Rik 96647_at AA645440 RIKEN cDNA 4833420K19 gene11064 0.83028 1.07 up Mm.27548 AW742596 160236_at AI835624 expressed sequence AW74259611065 0.83028 1.06 up Mm.27881 Usmg4 160761_at AA915203 upregulated during skeletal muscle growth 411066 0.83030 1.14 up Mm.4864 Mpl 92926_at Z22649 myeloproliferative leukemia virus oncogene11067 0.83042 1.12 down Mm.196083 Spi14 160972_at AA015547 serine protease inhibitor 1411068 0.83104 1.03 down Mm.13148 AI450991 102647_g_at AW122284 expressed sequence AI45099111069 0.83114 1.14 down Mm.3906 Map2k7 99037_at AF026216 mitogen activated protein kinase kinase 711070 0.83126 1.07 down Mm.31540 Vegfa 103520_at M95200 vascular endothelial growth factor APage 123 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description11071 0.83130 1.13 down Mm.16813 2700022J23Rik 103069_at AI853682 RIKEN cDNA 2700022J23 gene11072 0.83137 1.06 up Mm.4908 Csng 103243_at AF083876 casein gamma11073 0.83147 1.06 up Mm.1166 Pfkl 92637_at J03928 phosphofructokinase, liver, B-type11074 0.83167 1.10 up Mm.5008 Vpreb1 92972_at X05557 pre-B lymphocyte gene 111075 0.83179 1.09 up Mm.2990 Mm.2990 96572_at AW047232 ESTs11076 0.83187 1.08 up Mm.4732 Lamb3 92759_at U43298 laminin, beta 311077 0.83197 1.06 down Mm.29012 Fbxw4 96768_at AW122991 f-box and WD-40 domain protein 411078 0.83210 1.12 up Mm.2614 Guca2 96051_at M95175 guanylate cyclase activator 2 (guanylin 2, in<strong>test</strong>inal, heatstable)11079 0.83228 1.11 up Mm.42050 Xrn1 98283_at X91617 5'-3' exoribonuclease 111080 0.83234 1.06 up Mm.143842 Klk26 102693_f_at J00389 kallikrein 2611081 0.83238 1.06 down Mm.218648 Mm.218648 95028_r_at C77009 ESTs11082 0.83248 1.08 down Mm.24509 AA409156 95165_at AA409156 expressed sequence AA40915611083 0.83250 1.07 down Mm.1945 Pip5k1a 103573_at D86176 phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha11084 0.83252 1.09 up Mm.37370 Mm.37370 97688_at AI666506 ESTs, Weakly similar to JAK3 MOUSE TYROSINE-PROTEIN KINASE JAK311085 0.83259 1.08 down Mm.34446 Cdkn1a 94881_at AW048937 cyclin-dependent kinase inhibitor 1A (P21)11086 0.83266 1.07 down Mm.28415 Tlp 97893_at AB017697 TATA box binding protein-like protein11087 0.83277 1.11 up Mm.29274 AI415285 96811_at AW049806 expressed sequence AI41528511088 0.83288 1.06 down Mm.588 Rpl6 96962_at X81987 ribosomal protein L611089 0.83291 1.09 up Mm.27220 Nfyc 94969_at U62297 nuclear transcription factor-Y gamma11090 0.83319 1.10 up Mm.22176 4930506L07Rik 103489_at AA921481 RIKEN cDNA 4930506L07 gene11091 0.83326 1.14 up Mm.3249 Epha4 161866_at AV341298 Eph receptor A411092 0.83355 1.14 up Mm.5173 Siat8e 99320_at X98014 sialyltransferase 8 (alpha 2, 8 sialytransferase) E11093 0.83357 1.13 down Mm.34133 Cd6 92203_s_at U37543 CD6 antigen11094 0.83363 1.09 up Mm.3919 2810011G06Rik 92349_at AB006141 RIKEN cDNA 2810011G06 gene11095 0.83370 1.15 up Mm.28670 2610016K11Rik 161873_r_at AV076889 RIKEN cDNA 2610016K11 gene11096 0.83374 1.07 down 95794_f_at AJ00556711097 0.83396 1.04 down Mm.89968 Xpr1 103783_at AI648965 xenotropic and polytropic retrovirus receptor 111098 0.83403 1.12 down Mm.10001 Hccs 102007_at U36788 holocytochrome c synthetase11099 0.83404 1.14 up Mm.14138 Aeg2 94730_at M92850 acidic epididymal glycoprotein 211100 0.83405 1.07 up Mm.13430 Rai12 160077_at AF004107 retinoic acid induced 1211101 0.83414 1.06 up Mm.24091 1110001J03Rik 94908_r_at AW045632 RIKEN cDNA 1110001J03 gene11102 0.83424 1.06 up Mm.18637 Tera-pending 103385_at U64033 teratocarcinoma expressed, serine rich11103 0.83484 1.15 up Mm.28973 Icam1 101141_at M33036 intercellular adhesion molecule11104 0.83489 1.05 up Mm.2215 Tcof1 104145_at U81030 Treacher Collins Franceschetti syndrome 1, homolog11105 0.83495 1.08 up Mm.204986 Ifld2 161067_at AA770736 induced in fatty liver dystrophy 211106 0.83507 1.12 up Mm.1372 Pde6b 162167_f_at AV361022 phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide11107 0.83523 1.08 up Mm.5727 2610019F03Rik 100902_at AI846549 RIKEN cDNA 2610019F03 gene11108 0.83546 1.05 down Mm.4462 Sh3bp1 92666_at X87671 SH3-domain binding protein 111109 0.83554 1.07 up Mm.3419 AV149826 92208_at AI152966 expressed sequence AV14982611110 0.83565 1.10 up Mm.34977 Mm.34977 103491_at AA968123 ESTs, Weakly similar to F45E10.1.p [Caenorhabditis elegans] [C.elegans]11111 0.83577 1.06 down Mm.27223 Mm.27223 94970_at AI852314 ESTs, Weakly similar to A55817 cyclin-dependent kinase p130-PITSLRE - m11112 0.83579 1.09 up Mm.334 Solt 98400_at AA896295 SoxLZ/Sox6 leucine zipper binding protein in <strong>test</strong>is11113 0.83581 1.06 up Mm.12091 Rassf1 102379_at AW049415 ras association (RalGDS/AF-6) domain family 111114 0.83584 1.10 down Mm.28864 Mm.28864 162145_r_at AV343395 Mus musculus silencer-associated factor gene, complete cds11115 0.83584 1.14 down Mm.196331 Clca1 103812_at AF047838 chloride channel calcium activated 111116 0.83585 1.12 up Mm.104920 Sdh1 162078_at AV283713 sorbitol dehydrogenase 111117 0.83590 1.12 up Mm.42170 Kif9 92490_at AJ132889 kinesin 911118 0.83595 1.10 down Mm.35820 Cpo 98506_r_at D16333 coproporphyrinogen oxidase11119 0.83601 1.11 down Mm.20862 Reck 103804_at AB006960 reversion-inducing-cysteine-rich protein with kazal motifs11120 0.83609 1.04 up Mm.24222 Sphk2 162381_f_at AV246189 sphingosine kinase 211121 0.83645 1.06 up Mm.21117 Itgb4 103305_at L04678 integrin beta 411122 0.83652 1.06 up Mm.212527 Mm.212527 104393_at AI843571 Mus musculus, Similar to hypothetical protein MGC12966, clone MGC:1931511123 0.83656 1.16 up Mm.18443 Slc2a2 103357_at X15684 solute carrier family 2 (facilitated glucose transporter), member 211124 0.83667 1.12 up Mm.42135 Stag1 92478_at Z75332 stromal antigen 111125 0.83708 1.11 down Mm.149115 Birc4 93400_at U88990 baculoviral IAP repeat-containing 411126 0.83737 1.11 up Mm.143788 Ppp1r1a 96114_at AW122076 protein phosphatase 1, regulatory (inhibitor) subunit 1A11127 0.83739 1.12 down Mm.29123 AI315052 96792_at AI787317 expressed sequence AI31505211128 0.83759 1.09 down Mm.27532 4930487N19Rik 98381_at AI845895 RIKEN cDNA 4930487N19 gene11129 0.83763 1.05 up Mm.24083 Mm.24083 160377_at AW210064 Mus musculus, Similar to TAR DNA binding protein, clone MGC:19284 IMAG11130 0.83770 1.13 up Mm.25548 Kpna3 93857_at AF020772 karyopherin (importin) alpha 311131 0.83771 1.14 up Mm.934 Serpinf2 161916_r_at AV125820 serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigme11132 0.83784 1.08 down Mm.195073 Cryge 103026_f_at X57855 crystallin, gamma E11133 0.83788 1.04 down Mm.182912 Ghitm 100592_at AI929971 growth hormone inducible transmembrane protein11134 0.83821 1.09 up Mm.9493 Pabpc2 101938_at X75959 poly A binding protein, cytoplasmic 211135 0.83827 1.06 down Mm.141312 Col9a3 102070_at AW212495 procollagen, type IX, alpha 311136 0.83846 1.15 up Mm.954 2410153K17Rik 161950_at AV360487 RIKEN cDNA 2410153K17 gene11137 0.83874 1.14 up Mm.24895 Mm.24895 95945_at C76146 ESTs11138 0.83880 1.09 down Mm.22225 1110008J21Rik 94215_at AW050185 RIKEN cDNA 1110008J21 gene11139 0.83904 1.04 down Mm.28639 AU041016 96206_at AI854506 expressed sequence AU04101611140 0.83923 1.08 up Mm.3242 Gyk 97525_at U48403 glycerol kinase11141 0.83925 1.12 down Mm.6228 Kera 93387_at AF057301 keratocan11142 0.83932 1.10 down Mm.153729 2210010C04Rik 100104_r_at AE000663 RIKEN cDNA 2210010C04 gene11143 0.83946 1.13 down Mm.1297 Trap1a 102764_at M36387 tumor rejection antigen P1A11144 0.83958 1.09 up Mm.5195 Cplx1 101198_at D38614 complexin 111145 0.83999 1.11 up Mm.24816 F2r 95313_at AW046032 coagulation factor II (thrombin) receptor11146 0.84009 1.07 down Mm.2089 1110035H17Rik 101677_at AI450336 RIKEN cDNA 1110035H17 gene11147 0.84023 1.05 down Mm.23606 Mm.23606 103542_at AW215059 Mus musculus, Similar to KIAA1741 protein, clone IMAGE:5133740, mRNA,11148 0.84023 1.06 up Mm.20921 Igsf4 93605_r_at AF061260 immunoglobulin superfamily, member 411149 0.84030 1.14 up Mm.5079 Mm.5079 161517_at AV158580 Mus musculus, Similar to hydroxysteroid 11-beta dehydrogenase 2, clone MG11150 0.84035 1.05 up Mm.182061 0610013E23Rik 160507_at AA647239 RIKEN cDNA 0610013E23 gene11151 0.84071 1.06 up Mm.5567 Pdlim1 161348_r_at AV149007 PDZ and LIM domain 1 (elfin)11152 0.84080 1.10 up Mm.43157 C77803 99923_at AA615429 expressed sequence C7780311153 0.84088 1.03 down Mm.27183 Ebp 96627_at X97755 phenylalkylamine Ca2+ antagonist (emopamil) binding protein11154 0.84094 1.13 up Mm.20348 Nid2 93563_s_at AB017202 nidogen 211155 0.84113 1.11 up Mm.26743 Apoa1 96094_at U79573 apolipoprotein A-I11156 0.84117 1.06 down Mm.29389 Mm.29389 96825_at AI854794 Mus musculus, Similar to KIAA1075 protein, clone IMAGE:5099327, mRNA,11157 0.84120 1.05 down Mm.20216 AI327030 160121_at AW125050 expressed sequence AI32703011158 0.84124 1.06 up Mm.42209 Tecta 98315_at X99805 tectorin alpha11159 0.84133 1.10 up Mm.98200 Cyp2j6 92813_at U62295 cytochrome P450, 2j611160 0.84144 1.09 up Mm.43925 C79246 102136_r_at C79246 expressed sequence C79246Page 124 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description11161 0.84152 1.05 down Mm.15801 Lcn7 160613_at AW049768 lipocalin 711162 0.84166 1.05 up Mm.468 Rp9h 160514_at D78255 retinitis pigmentosa 9 homolog (human)11163 0.84167 1.05 down Mm.171335 AW125446 97478_at AW046965 expressed sequence AW12544611164 0.84170 1.09 down Mm.3516 Hes3 97156_at D32200 hairy and enhancer of split 3, (Drosophila)11165 0.84176 1.06 up 97562_r_at AF03165111166 0.84193 1.20 up Mm.14191 Klkbp 102706_i_at X61597 kallikrein binding protein11167 0.84213 1.04 down Mm.34289 H2-Bl 101681_f_at U21906 histocompatibility 2, blastocyst11168 0.84250 1.07 up Mm.27785 AU018638 95564_at AI117859 expressed sequence AU01863811169 0.84255 1.09 down Mm.212870 Ifi204 161180_r_at AV233170 interferon activated gene 20411170 0.84255 1.10 up Mm.42045 Gsg2 99522_at D87326 germ cell-specific gene 211171 0.84266 1.05 down Mm.16976 Taf9 103074_f_at AI842969 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor11172 0.84267 1.09 up Mm.2607 Mm.2607 161587_at AV321289 Mus musculus adult male liver cDNA, RIKEN full-length enriched library, clon11173 0.84274 1.04 down Mm.43640 4921506J03Rik 99645_at AW048484 RIKEN cDNA 4921506J03 gene11174 0.84287 1.08 up Mm.28927 2310005N03Rik 160315_at AI843155 RIKEN cDNA 2310005N03 gene11175 0.84292 1.08 down Mm.35830 Hbb-y 103533_at X14061 hemoglobin Y, beta-like embryonic chain11176 0.84356 1.07 down Mm.29802 Mm.29802 96242_at AW125751 Mus musculus, Similar to CGI-67 protein, clone MGC:11699 IMAGE:39640911177 0.84358 1.11 down Mm.184351 Aqp4 102703_s_at U48398 aquaporin 411178 0.84388 1.04 down Mm.22252 4432405K22Rik 104283_at AI037493 RIKEN cDNA 4432405K22 gene11179 0.84423 1.05 up Mm.3091 Epn1 104514_at AF057285 epsin 111180 0.84432 1.11 up Mm.2679 Agtr2 94934_at U04828 angiotensin II receptor, type 211181 0.84450 1.08 down Mm.44885 Mm.44885 98379_r_at AW122568 ESTs11182 0.84454 1.04 down Mm.34118 Gjb2 98423_at M81445 gap junction membrane channel protein beta 211183 0.84461 1.11 down Mm.3379 Shmt1 104700_at X94478 serine hydroxymethyl transferase 1 (soluble)11184 0.84473 1.08 down Mm.29076 2510010F10Rik 160325_r_at L22067 RIKEN cDNA 2510010F10 gene11185 0.84486 1.08 down Mm.10695 Neurod4 94123_at AF036257 neurogenic differentiation 411186 0.84508 1.11 down Mm.4683 Fancc 161709_at AV245037 Fanconi anemia, complementation group C11187 0.84508 1.04 down Mm.2785 Dbi 97248_at X61431 diazepam binding inhibitor11188 0.84512 1.10 up Mm.206467 Mknk1 92464_at Y11091 MAP kinase-interacting serine/threonine kinase 111189 0.84529 1.11 up Mm.57220 Fv1 99807_r_at X97720 Friend virus susceptibility 111190 0.84532 1.04 down Mm.41687 1110039H05Rik 99167_at AW122550 RIKEN cDNA 1110039H05 gene11191 0.84543 1.11 down Mm.42223 Chic1 98316_at Y11896 cysteine-rich hydrophobic domain 111192 0.84572 1.05 down Mm.2000 Mm.2000 162466_at AV063221 ESTs, Highly similar to THROMBOSPONDIN 2 PRECURSOR [M.musculus]11193 0.84573 1.13 down Mm.1333 Pcsk1 94694_at M69196 proprotein convertase subtilisin/kexin type 111194 0.84598 1.05 up Mm.3670 Cct2 160442_at AB022156 chaperonin subunit 2 (beta)11195 0.84609 1.03 up Mm.27348 Rala 103067_at Z48587 v-ral simian leukemia viral oncogene homolog A (ras related)11196 0.84627 1.06 down Mm.22593 Gtf2i 162493_r_at AV146566 general transcription factor II I11197 0.84627 1.10 up Mm.41746 Rpo2tc1 101980_at J03750 RNA polymerase II transcriptional coactivator11198 0.84628 1.15 up Mm.196559 Hsp70-3 93875_at M12571 heat shock protein, 70 kDa 311199 0.84658 1.12 up Mm.1890 a 102977_at L06451 nonagouti11200 0.84718 1.07 up Mm.143731 Abcb10 104394_at AW121609 ATP-binding cassette, sub-family B (MDR/TAP), member 1011201 0.84721 1.10 up Mm.29269 2410001H17Rik 160334_at AI851945 RIKEN cDNA 2410001H17 gene11202 0.84744 1.13 up Mm.18004 Mm.18004 94797_at AI120514 Mus musculus, Similar to sulfate anion transporter, clone MGC:37809 IMAG11203 0.84746 1.05 up Mm.3688 Mnat1 98979_at U35249 menage a trois 111204 0.84754 1.06 down Mm.154456 Cyb561 92391_at U16297 cytochrome b-56111205 0.84775 1.06 down Mm.2915 Faah 96795_at AF098009 fatty acid amide hydrolase11206 0.84817 1.10 down Mm.16926 Mm.16926 102937_at AA636300 ESTs, Weakly similar to T16421 hypothetical protein F52C9.4 - Caenorhabd11207 0.84821 1.06 up Mm.45558 2010008K16Rik 100013_at AW121732 RIKEN cDNA 2010008K16 gene11208 0.84826 1.06 up Mm.10 Srm 101291_at Z83956 spermidine synthase11209 0.84830 1.09 up Mm.4875 Dll1 92931_at X80903 delta-like 1 (Drosophila)11210 0.84833 1.06 up Mm.20869 Atp6n1a 103275_at U13836 ATPase, H+ transporting, lysosomal (vacuolar proton pump) noncatalytic acc11211 0.84845 1.05 up Mm.533 Lta4h 100540_at M63848 leukotriene A4 hydrolase11212 0.84855 1.08 up Mm.41991 D0H6S2654E 97785_at Y18506 DNA segment, human D6S2654E11213 0.84857 1.04 up Mm.24541 2210403N23Rik 95438_at AI846783 RIKEN cDNA 2210403N23 gene11214 0.84859 1.16 down Mm.58507 Kcne1l 100907_at AJ131398 potassium voltage-gated channel, Isk-related family, member 1-like11215 0.84889 1.08 down Mm.141054 5530600A18Rik 94955_at AW125433 RIKEN cDNA 5530600A18 gene11216 0.84902 1.04 up Mm.2209 Cd4 160531_at AC002397 CD4 antigen11217 0.84918 1.10 up Mm.42960 2610301D06Rik 161958_at AV221082 RIKEN cDNA 2610301D06 gene11218 0.84922 1.04 down Mm.1920 Ube2b 93509_at U57690 ubiquitin-conjugating enzyme E2B, RAD6 homology (S. cerevisiae)11219 0.84923 1.08 up Mm.3272 Ramp1 104680_at AJ250489 receptor (calcitonin) activity modifying protein 111220 0.84956 1.07 down Mm.30424 Ptger3 96588_at D10204 prostaglandin E receptor 3 (subtype EP3)11221 0.84980 1.07 down Mm.4847 Klf1 100452_at M97200 Kruppel-like factor 1 (erythroid)11222 0.84995 1.08 up Mm.22627 Eps15 104367_at AW124983 epidermal growth factor receptor pathway substrate 1511223 0.85003 1.08 down Mm.21881 TOB3 162418_r_at AV323555 TOB311224 0.85006 1.04 down Mm.87776 H2-T10 101876_s_at M35247 histocompatibility 2, T region locus 1011225 0.85037 1.16 down Mm.21737 C79430 103463_at AI504260 expressed sequence C7943011226 0.85045 1.03 down Mm.3989 Mcpr 99068_at X80169 meiotic check point regulator11227 0.85046 1.08 up Mm.31946 1810063B05Rik 160411_at AW121765 RIKEN cDNA 1810063B05 gene11228 0.85093 1.09 down Mm.29738 Apoa5 95729_at AA674450 apolipoprotein A-V11229 0.85101 1.07 up Mm.1399 Gcm2 94709_at D88611 glial cells missing homolog 2 (Drosophila)11230 0.85106 1.11 down Mm.42021 Gria3 97793_at AB022342 glutamate receptor, ionotropic, AMPA3 (alpha 3)11231 0.85107 1.07 up Mm.6787 Sfrs3 101004_f_at X91656 splicing factor, arginine/serine-rich 3 (SRp20)11232 0.85112 1.06 up Mm.28376 2210408F11Rik 104254_at AI839876 RIKEN cDNA 2210408F11 gene11233 0.85121 1.08 down Mm.1224 Cd3z 102288_at L03353 CD3 antigen, zeta polypeptide11234 0.85126 1.07 down Mm.558 Wnt8a 99361_at Z68889 wingless-related MMTV integration site 8A11235 0.85139 1.04 up Mm.13917 2700038K18Rik 92857_at AI853960 RIKEN cDNA 2700038K18 gene11236 0.85147 1.04 down Mm.41667 Mettl1 99499_at AB023619 methyltransferase-like 1 (S. cerevisiae)11237 0.85171 1.06 down Mm.23082 3110041O18Rik 92437_at AW047445 RIKEN cDNA 3110041O18 gene11238 0.85197 1.09 up Mm.14442 Ndufs4 92876_at AA590675 NADH dehydrogenase (ubiquinone) Fe-S protein 411239 0.85219 1.14 down Mm.210519 MP4 93649_f_at M11897 proline rich protein MP411240 0.85220 1.06 up Mm.42154 Trif-pending 99529_f_at AB025011 Trif gene11241 0.85226 1.09 down Mm.43587 Hpca 99944_at AB015200 hippocalcin11242 0.85231 1.09 up Mm.34789 1200014P03Rik 98462_s_at AI322968 RIKEN cDNA 1200014P03 gene11243 0.85248 1.08 down Mm.140810 Mm.140810 101219_at C76428 ESTs, Weakly similar to YO11 MOUSE HYPOTHETICAL PROTEIN ORF-1111244 0.85283 1.10 up Mm.57245 Hsp70-2 99816_at M20567 heat shock protein, 70 kDa 211245 0.85303 1.08 up Mm.7457 Agxt 93625_at AA986718 alanine-glyoxylate aminotransferase11246 0.85318 1.06 down Mm.182195 3200002M19Rik 98493_at AA867026 RIKEN cDNA 3200002M19 gene11247 0.85322 1.07 up Mm.1249 Lamc1 161706_f_at AV244043 laminin, gamma 111248 0.85324 1.08 up Mm.133263 2610507L03Rik 102011_at AI850992 RIKEN cDNA 2610507L03 gene11249 0.85366 1.04 down Mm.206768 Ero1l 97871_at AW120614 ERO1-like (S. cerevisiae)11250 0.85404 1.03 down Mm.20937 Hpcal1 103835_f_at AF085192 hippocalcin-like 1Page 125 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description11251 0.85456 1.05 down Mm.206021 2810442O16Rik 101505_at AW121234 RIKEN cDNA 2810442O16 gene11252 0.85457 1.08 up Mm.12866 Chst3 94170_at AB008937 carbohydrate (chondroitin 6/keratan) sulfotransferase 311253 0.85503 1.06 up Mm.46801 Mm.46801 101346_at Z95476 M.musculus mRNA (2F7) for IgA V-D-J-heavy chain11254 0.85517 1.08 up Mm.29852 Mm.29852 161919_r_at AV134808 Mus musculus, clone IMAGE:5102170, mRNA, partial cds11255 0.85527 1.12 down Mm.38963 Cyp2c37 99083_at AF047542 cytochrome P450, 2c3711256 0.85529 1.07 down Mm.26599 2310001A20Rik 160217_at AI842715 RIKEN cDNA 2310001A20 gene11257 0.85549 1.11 down Mm.12966 S3-12-pending 102763_at AF064748 plasma membrane associated protein, S3-1211258 0.85559 1.09 down Mm.103632 Rasl2-9 161839_f_at AV043011 RAS-like, family 2, locus 911259 0.85560 1.09 up Mm.24331 Asb3 161466_r_at AV347947 ankyrin repeat and SOCS box-containing protein 311260 0.85569 1.03 up Mm.4467 2510027N19Rik 100057_at AI838320 RIKEN cDNA 2510027N19 gene11261 0.85636 1.05 up Mm.3909 Smarca3 92345_g_at AF010600 SWI/SNF related, matrix associated, actin dependent regulator of chromatin,11262 0.85640 1.04 down Mm.25148 5730403E06Rik 160202_at AI845108 RIKEN cDNA 5730403E06 gene11263 0.85642 1.10 up Mm.11756 Il8rb 94137_at L13239 interleukin 8 receptor, beta11264 0.85665 1.14 down Mm.5132 Bid3 101189_at D83698 BH3 interacting (with BCL2 family) domain, apoptosis agonist11265 0.85680 1.04 down Mm.206498 Mm.206498 104067_at AI648999 Mus musculus, Similar to spindle pole body protein, clone IMAGE:5324982,11266 0.85685 1.07 up Mm.133800 Tulp2 160863_at X69827 tubby-like protein 211267 0.85692 1.05 down Mm.1635 Pias3 161994_f_at AV327290 protein inhibitor of activated STAT 311268 0.85699 1.07 up Mm.28146 Mvd 160770_at AW049778 diphosphomevalonate decarboxylase11269 0.85711 1.04 down Mm.27033 Hcarg-pending 94945_at AI847650 hypertension-related, calcium regulated gene11270 0.85715 1.04 down Mm.6874 Surf1 100910_at M14689 surfeit gene 111271 0.85729 1.06 down Mm.200712 D5Ertd135e 103786_at AA790291 DNA segment, Chr 5, ERATO Doi 135, expressed11272 0.85754 1.04 up Mm.28235 Rnf7 97836_at AI843444 ring finger protein 711273 0.85764 1.03 down Mm.196515 D1Ertd692e 160265_at AW123979 DNA segment, Chr 1, ERATO Doi 692, expressed11274 0.85769 1.05 down Mm.22668 Hmgcl 161970_f_at AV371169 3-hydroxy-3-methylglutaryl-Coenzyme A lyase11275 0.85829 1.04 down Mm.10507 Emap2 92578_at U10118 endothelial monocyte activating polypeptide 211276 0.85832 1.05 down Mm.28761 Stk25 98955_at AF004934 serine/threonine kinase 25 (yeast)11277 0.85855 1.12 up Mm.116802 Nfatc2 93075_r_at U36575 nuclear factor of activated T-cells, cytoplasmic 211278 0.85871 1.05 up Mm.2870 Rpa2 98943_at D00812 replication protein A211279 0.85872 1.08 down Mm.3368 Spi6 102125_f_at AI838923 serine protease inhibitor 611280 0.85876 1.07 up Mm.5935 AI317193 93241_r_at AI838094 expressed sequence AI31719311281 0.85892 1.08 up Mm.3142 Ache 104650_at X56518 acetylcholinesterase11282 0.85899 1.09 up Mm.21145 Amotl2 160131_at AI854404 angiomotin like 211283 0.85907 1.04 down Mm.364 Mrps12 98547_at Y11682 mitochondrial ribosomal protein S1211284 0.85915 1.14 down Mm.14460 Akr1b7 102826_at J05663 aldo-keto reductase family 1, member B711285 0.85917 1.11 down Mm.8122 Tenr 97661_at X84693 <strong>test</strong>is nuclear RNA binding protein11286 0.85929 1.09 up Mm.13081 Sc5d 102768_i_at AB016248 sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevis11287 0.85943 1.06 down Mm.6510 Zp2 162261_f_at AV357250 zona pellucida glycoprotein 211288 0.85956 1.05 down Mm.4818 Cdk5 100444_at D29678 cyclin-dependent kinase 511289 0.85975 1.05 down Mm.26722 Ndr2 96088_at AB033921 N-myc downstream regulated 211290 0.85986 1.09 down Mm.2918 Matk 104428_s_at D45243 megakaryocyte-associated tyrosine kinase11291 0.85992 1.05 down Mm.202775 2610007A16Rik 160758_at AW124855 RIKEN cDNA 2610007A16 gene11292 0.85998 1.03 up Mm.29924 Arl6ip 160371_at AW122878 ADP-ribosylation-like factor 6 interacting protein11293 0.86006 1.09 up Mm.195337 D11Ertd166e 101230_at C78294 DNA segment, Chr 11, ERATO Doi 166, expressed11294 0.86008 1.05 up Mm.15694 Hira 102709_at AW125193 histone cell cycle regulation defective homolog A (S. cerevisiae)11295 0.86041 1.03 down Mm.3798 Fah 98588_at Z11774 fumarylacetoacetate hydrolase11296 0.86053 1.15 up Mm.3692 Cts7 97678_r_at AV294670 cathepsin 711297 0.86058 1.06 up Mm.157012 Tcrb-V13 101311_at M31648 T-cell receptor beta, variable 1311298 0.86060 1.06 down Mm.8551 Sp100 101848_g_at AF040242 nuclear antigen Sp10011299 0.86068 1.05 down Mm.82938 Mm.82938 161083_at AW121616 ESTs, Weakly similar to T17365 serine/threonine protein kinase TAO1 - rat [11300 0.86083 1.04 up Mm.1703 Tubb5 94788_f_at X04663 tubulin, beta 511301 0.86086 1.04 up Mm.2904 Zfp216 160321_at AF062071 zinc finger protein 21611302 0.86097 1.06 up Mm.38930 AA407558 99031_at AI854005 expressed sequence AA40755811303 0.86118 1.14 up Mm.5067 Map3k2 101175_at U43186 mitogen activated protein kinase kinase kinase 211304 0.86121 1.03 down Mm.22428 3110040D16Rik 94260_at AI850352 RIKEN cDNA 3110040D16 gene11305 0.86136 1.11 up Mm.202379 Crkol 103849_at X90648 v-crk avian sarcoma virus CT10 oncogene homolog-like11306 0.86145 1.10 up Mm.36878 Psg19 97196_at X98111 pregnancy specific glycoprotein 1911307 0.86152 1.04 down Mm.28909 Ptp4a1 94489_at U84411 protein tyrosine phosphatase 4a111308 0.86170 1.03 down Mm.4480 Rbbp6 99990_at U28789 retinoblastoma binding protein 611309 0.86185 1.04 down Mm.182318 Psmd1 95483_at AW123318 proteasome (prosome, macropain) 26S subunit, non-ATPase, 111310 0.86239 1.09 up Mm.5023 Pcp4 162300_at AV031892 Purkinje cell protein 411311 0.86244 1.07 down 99702_at AF07811211312 0.86245 1.10 up Mm.25365 Evx2 96507_at M93128 even skipped homeotic gene 2 homolog11313 0.86268 1.12 down Mm.25539 Cryl1 161779_r_at AV360058 crystallin, lamda 111314 0.86286 1.08 up Mm.3292 Grin1 104685_g_at AI847120 glutamate receptor, ionotropic, NMDA1 (zeta 1)11315 0.86290 1.06 down Mm.41209 Rasal1 92417_at AF086714 RAS protein activator like 1 (GAP1 like)11316 0.86290 1.07 down Mm.15446 Wrn 102891_at D86527 Werner syndrome homolog (human)11317 0.86321 1.03 up Mm.29685 Dnajc8 95700_r_at AI848094 DnaJ (Hsp40) homolog, subfamily C, member 811318 0.86330 1.09 down Mm.27917 1200003E16Rik 95595_at AW122078 RIKEN cDNA 1200003E16 gene11319 0.86357 1.16 up Mm.140811 Hsd3b1 161261_f_at AV290268 hydroxysteroid dehydrogenase-1, delta-3-beta11320 0.86357 1.07 down Mm.30140 Mm.30140 96910_at AA986100 Mus musculus, clone IMAGE:4974743, mRNA, partial cds11321 0.86371 1.06 down Mm.154580 9430059D04Rik 99591_i_at AB030505 RIKEN cDNA 9430059D04 gene11322 0.86374 1.04 down Mm.22679 1300019P08Rik 162358_i_at AV218217 RIKEN cDNA 1300019P08 gene11323 0.86377 1.07 up Mm.6167 Hoxc8 93378_at X07439 homeo box C811324 0.86381 1.05 down Mm.11593 AU020772 102357_at AW122431 expressed sequence AU02077211325 0.86395 1.07 up Mm.2545 Aqr 103950_at U90333 aquarius11326 0.86412 1.05 up Mm.156616 Rnf42 95157_at AA763950 ring finger protein 4211327 0.86415 1.10 up Mm.24937 1500001M20Rik 160723_at AW124848 RIKEN cDNA 1500001M20 gene11328 0.86420 1.05 up Mm.27863 Mrps10 97251_at AI842124 mitochondrial ribosomal protein S1011329 0.86425 1.12 down Mm.88216 Snrpb 161335_r_at AV118626 small nuclear ribonucleoprotein B11330 0.86451 1.05 up Mm.182294 2310042G06Rik 96871_at AI844355 RIKEN cDNA 2310042G06 gene11331 0.86458 1.05 up Mm.24859 1500015J03Rik 104762_r_at AI850753 RIKEN cDNA 1500015J03 gene11332 0.86465 1.05 up Mm.16767 Hnrpa2b1 93118_at AI844131 heterogeneous nuclear ribonucleoprotein A2/B111333 0.86468 1.06 down Mm.3241 AA409897 98017_at AI852928 expressed sequence AA40989711334 0.86476 1.06 down Mm.27512 6330503C17Rik 104196_at AA711908 RIKEN cDNA 6330503C17 gene11335 0.86501 1.05 up Mm.29900 2310050B20Rik 97403_at AW045743 RIKEN cDNA 2310050B20 gene11336 0.86516 1.03 up Mm.158281 2310003K17Rik 97470_at D86424 RIKEN cDNA 2310003K17 gene11337 0.86522 1.03 down Mm.123110 Spnb2 93571_at M74773 beta-spectrin 2, non-erythrocytic11338 0.86540 1.08 down Mm.3522 Fprl1 100741_at U78299 formyl peptide receptor-like 111339 0.86557 1.06 down Mm.153701 D6-pending 98309_at Y12879 D6 beta-chemokine receptor11340 0.86589 1.07 down Mm.182255 Cd97 97832_at AA754887 CD97 antigenPage 126 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description11341 0.86617 1.04 down Mm.7142 Mbd3 101385_at AW047312 methyl-CpG binding domain protein 311342 0.86619 1.09 down Mm.19353 LOC56304 101616_at M19911 recombinant antineuraminidase single chain Ig VH and VL domains11343 0.86622 1.07 down Mm.16756 Si 102930_at U14133 silver11344 0.86624 1.04 up Mm.18795 1300010O06Rik 103717_at AA921411 RIKEN cDNA 1300010O06 gene11345 0.86627 1.04 down Mm.3204 Fdft1 97518_at D29016 farnesyl diphosphate farnesyl transferase 111346 0.86650 1.09 up Mm.35498 Kin 160842_at X58472 antigenic determinant of rec-A protein11347 0.86652 1.05 up Mm.41046 Mm.41046 92408_at AI891514 ESTs, Weakly similar to D1069.3.p [Caenorhabditis elegans] [C.elegans]11348 0.86655 1.08 up Mm.717 Pgk2 101388_at M17299 phosphoglycerate kinase 211349 0.86689 1.07 up Mm.27141 Racgap1 94953_at AW122347 Rac GTPase-activating protein 111350 0.86697 1.09 down Mm.86386 Dffb 100294_at AB009377 DNA fragmentation factor, 40 kD, beta subunit11351 0.86699 1.03 up Mm.21184 D2Wsu58e 103877_at AW060485 DNA segment, Chr 2, Wayne State University 58, expressed11352 0.86711 1.09 down Mm.93826 Mm.93826 162256_r_at AV336991 ESTs11353 0.86717 1.05 down Mm.20843 Tomm40 160653_at AF043249 translocase of outer mitochondrial membrane 40 homolog (yeast)11354 0.86719 1.08 down Mm.206770 Cnot7 162314_at AV057025 CCR4-NOT transcription complex, subunit 711355 0.86737 1.04 down Mm.24092 Nsf 102342_at U10120 N-ethylmaleimide sensitive fusion protein11356 0.86749 1.05 down Mm.19185 Tcirg1 103205_at AI286861 T-cell, immune regulator 111357 0.86800 1.10 down Mm.41326 Gbl-pending 161602_at AV304227 G protein beta subunit-like11358 0.86801 1.06 up Mm.29909 1810005K14Rik 95848_at C76063 RIKEN cDNA 1810005K14 gene11359 0.86812 1.05 down Mm.34261 AW557761 98047_at AI851583 expressed sequence AW55776111360 0.86813 1.05 up Mm.16976 Taf9 93918_at AA673500 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor11361 0.86815 1.09 down Mm.70169 Mm.70169 161144_r_at AV217223 ESTs, Weakly similar to GDF3 MOUSE GROWTH/DIFFERENTIATION FAC11362 0.86815 1.04 up Mm.27131 0610037N01Rik 96618_at AW045637 RIKEN cDNA 0610037N01 gene11363 0.86827 1.05 up Mm.12889 Krtap13 94183_at AF031485 keratin associated protein 1311364 0.86833 1.02 up Mm.22588 AU024053 104360_at AI841844 expressed sequence AU02405311365 0.86838 1.04 up Mm.10229 Nssr 102046_at AF042383 neural-salient serine/arginine-rich11366 0.86854 1.03 down Mm.27393 Timm17b 96668_at AI845867 translocator of inner mitochondrial membrane 17 kDa, b11367 0.86854 1.03 up Mm.28950 Acp6 96744_at AW061051 acid phosphatase 6, lysophosphatidic11368 0.86859 1.06 down Mm.28101 Mm.28101 160768_at AI461837 Mus musculus, Similar to hypothetical protein FLJ10110, clone MGC:2816411369 0.86861 1.06 up Mm.39090 Grin2c 97726_at L35029 glutamate receptor, ionotropic, NMDA2C (epsilon 3)11370 0.86869 1.09 up Mm.1911 AA410048 103203_f_at AW259499 expressed sequence AA41004811371 0.86900 1.11 down Mm.27318 Rac3 104180_at AA967636 RAC311372 0.86905 1.03 up Mm.22514 0610008F14Rik 161145_f_at AV217314 RIKEN cDNA 0610008F14 gene11373 0.86921 1.07 down Mm.154195 2810417D08Rik 161812_r_at AV373134 RIKEN cDNA 2810417D08 gene11374 0.86954 1.05 down Mm.25339 Mta1l1 96003_at AW048332 metastasis associated 1-like 111375 0.86968 1.04 up Mm.7268 Trap100-pending 101402_at AI854510 thyroid hormone receptor-associated protein 100 kDa11376 0.86979 1.04 down Mm.17958 Rga 102960_at X96618 recombination activating gene 1 gene activation11377 0.86988 1.08 up Mm.140811 Hsd3b1 103072_at M58567 hydroxysteroid dehydrogenase-1, delta-3-beta11378 0.86991 1.08 up Mm.215493 Mm.215493 97707_at AI604097 ESTs, Highly similar to S12207 hypothetical protein [M.musculus]11379 0.87024 1.09 down Mm.57171 Bmp10 101815_at AF101440 bone morphogenetic protein 1011380 0.87032 1.06 up Mm.202667 AI035669 96517_at AI035669 expressed sequence AI03566911381 0.87056 1.02 down Mm.12746 1110004D19Rik 92806_at AI843868 RIKEN cDNA 1110004D19 gene11382 0.87062 1.08 up Mm.219622 2210418O10Rik 100321_f_at AA407120 RIKEN cDNA 2210418O10 gene11383 0.87079 1.12 up Mm.25249 AI594671 96499_at AI594671 expressed sequence AI59467111384 0.87106 1.06 up Mm.42222 Utrn 92508_s_at X83506 utrophin11385 0.87121 1.05 up Mm.8866 Mllt10 93878_at AF010135 myeloid/lymphoid or mixed lineage-leukemia translocation to 10 homolog (Dr11386 0.87121 1.06 down Mm.179 Ebf2 102958_at U82441 early B-cell factor 211387 0.87131 1.03 up Mm.1511 Mm.1511 102982_at AI854581 ESTs, Weakly similar to T00374 hypothetical protein KIAA0648 [H.sapiens]11388 0.87157 1.05 up Mm.28954 Wrch1-pending 96747_at AW121294 Wnt1 responsive Cdc42 homolog11389 0.87161 1.03 down Mm.20260 Mlycd 103622_at AW050255 malonyl-CoA decarboxylase11390 0.87164 1.04 up Mm.153481 Canx 160180_at AI853036 calnexin11391 0.87184 1.08 down Mm.218854 Veli3-pending 161086_at AF087695 vertebrate homolog of C. elegans Lin-7 type 311392 0.87193 1.10 down Mm.89048 F2 101899_at X52308 coagulation factor II11393 0.87199 1.05 up Mm.71710 Axin2 99239_at AF073788 axin211394 0.87208 1.04 up Mm.24527 AA408566 103753_at AI159572 expressed sequence AA40856611395 0.87213 1.03 up Mm.83615 Trrp2 96939_at AI842649 transient receptor protein 211396 0.87213 1.05 up Mm.26540 4930432O21Rik 160725_at AI121251 RIKEN cDNA 4930432O21 gene11397 0.87216 1.10 down Mm.42230 Cyp26a1 98320_at Y12657 cytochrome P450, 26, retinoic acid A111398 0.87221 1.03 up Mm.27490 Mm.27490 95023_at AW050353 Mus musculus, Similar to hypothetical protein FLJ20174, clone IMAGE:359511399 0.87229 1.09 down Mm.4405 Chx10 101127_at L34808 C. elegans ceh-10 homeo domain containing homolog11400 0.87246 1.13 up Mm.4947 Fgf3 92957_at Y00848 fibroblast growth factor 311401 0.87265 1.05 up Mm.3957 Mm.3957 97738_r_at AW121931 ESTs, Weakly similar to T17255 hypothetical protein DKFZp586O1822.1 [H.11402 0.87289 1.08 up Mm.89948 Opn1mw 101679_at AI462500 opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan)11403 0.87290 1.12 down Mm.196770 Bcl2a1b 102913_at AI324342 B-cell leukemia/lymphoma 2 related protein A1b11404 0.87302 1.03 down Mm.14287 Hspa1l 101546_at AF109906 heat shock 70kD protein 1-like11405 0.87309 1.04 up Mm.182607 Eplin-pending 94561_at AI836140 epithelial protein lost in neoplasm11406 0.87310 1.03 down Mm.18798 2410004J02Rik 103406_at AI853967 RIKEN cDNA 2410004J02 gene11407 0.87314 1.04 down Mm.32033 Rps6ka2 98007_at AJ131021 ribosomal protein S6 kinase, 90kD, polypeptide 211408 0.87357 1.03 down Mm.181892 5230400G24Rik 95140_at AI842068 RIKEN cDNA 5230400G24 gene11409 0.87358 1.07 up Mm.28904 D15Ertd781e 97184_at AI528219 DNA segment, Chr 15, ERATO Doi 781, expressed11410 0.87370 1.03 down Mm.27218 Mrgx-pending 96632_at AB025049 MORF-related gene X11411 0.87374 1.03 down Mm.29317 Actr11-pending 95097_at AI851227 actin-related protein 11 homolog (S. cerevisiae)11412 0.87385 1.03 up Mm.1989 Sca2 93535_at AF041472 spinocerebellar ataxia 2 homolog (human)11413 0.87386 1.06 down Mm.28774 Mm.28774 162022_f_at AV362882 ESTs11414 0.87455 1.05 down Mm.118 Sap30 160068_at AF075136 sin3 associated polypeptide, 30kD11415 0.87458 1.11 up Mm.22753 Ctsb 95608_at AI851255 cathepsin B11416 0.87466 1.03 down Mm.41670 2410004J23Rik 99162_at AW122398 RIKEN cDNA 2410004J23 gene11417 0.87502 1.02 down Mm.22665 Hdac5 104376_at AF006602 histone deacetylase 511418 0.87505 1.04 up Mm.10125 Cdv1 161093_at AW214325 carnitine deficiency-associated gene expressed in ventricle 111419 0.87510 1.04 down Mm.3863 Por 99019_at D17571 P450 (cytochrome) oxidoreductase11420 0.87524 1.08 up Mm.27445 Fbxo6b 162050_at AV380739 f-box only protein 6b11421 0.87529 1.07 up Mm.1013 Lig1 92551_at U19604 ligase I, DNA, ATP-dependent11422 0.87538 1.07 down Mm.10758 Mm.10758 102253_at AF067063 Mus musculus clone L2 uniform group of 2-cell-stage gene family mRNA, co11423 0.87574 1.12 down Mm.2386 Scg3 104564_at U02982 secretogranin III11424 0.87579 1.12 down Mm.29730 Fjx1 160816_at AJ009634 four jointed box 1 (Drosophila)11425 0.87583 1.03 down Mm.28805 Set 94456_at AI841497 SET translocation11426 0.87590 1.06 down Mm.29482 D11Moh34 160228_at AI838249 DNA segment, Chr 11, KL Mohlke 3411427 0.87595 1.02 up Mm.24565 Timm23 95441_at AB021122 translocase of inner mitochondrial membrane 23 homolog (yeast)11428 0.87618 1.04 up Mm.34570 Rpo1-3 98081_at AI853173 RNA polymerase 1-3 (16 kDa subunit)11429 0.87625 1.03 up Mm.179091 1500031K13Rik 97482_at AA832565 RIKEN cDNA 1500031K13 gene11430 0.87634 1.07 down Mm.104747 Igk-V28 100299_f_at U55576 immunoglobulin kappa chain variable 28 (V28)Page 127 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description11431 0.87646 1.10 up Mm.2735 Cubn 95000_g_at AJ010338 cubilin (intrinsic factor-cobalamin receptor)11432 0.87647 1.05 down Mm.21158 Frap1 95302_at AI854595 FK506 binding protein 12-rapamycin associated protein 111433 0.87664 1.03 up Mm.29412 Ncor2 95129_at AW121057 nuclear receptor co-repressor 211434 0.87668 1.05 up Mm.15093 Slc22a1l 102861_at AF028739 solute carrier family 22 (organic cation transporter), member 1-like11435 0.87675 1.06 up Mm.28100 1300002P22Rik 97316_at AJ011864 RIKEN cDNA 1300002P22 gene11436 0.87681 1.05 down Mm.20912 Cdc6 103821_at AJ223087 cell division cycle 6 homolog (S. cerevisiae)11437 0.87688 1.07 up Mm.17949 Mrps22 160621_at AI852322 mitochondrial ribosomal protein S2211438 0.87717 1.07 down Mm.131074 C030048H19Rik 162118_f_at AV369001 RIKEN cDNA C030048H19 gene11439 0.87723 1.05 up Mm.27035 Qscn6 96603_at AW123556 quiescin Q611440 0.87738 1.07 down Mm.176231 Mm.176231 161496_r_at AV092260 EST11441 0.87748 1.05 down Mm.12917 Men1 102753_at AB023401 multiple endocrine neoplasia 111442 0.87754 1.07 down Mm.144157 Ghrh 160910_at M31654 growth hormone releasing hormone11443 0.87755 1.03 up Mm.4165 Sh3d3 99158_at U58888 SH3 domain protein 311444 0.87759 1.04 down Mm.28326 9430010M12Rik 97863_at AW125274 RIKEN cDNA 9430010M12 gene11445 0.87781 1.04 down Mm.3842 Nnt 99009_at Z49204 nicotinamide nucleotide transhydrogenase11446 0.87782 1.09 up Mm.37210 Ap1g1 161593_r_at AV291690 adaptor protein complex AP-1, gamma 1 subunit11447 0.87791 1.06 down Mm.2805 Dclre1a 104230_at AI225445 DNA cross-link repair 1A, PSO2 homolog (S. cerevisiae)11448 0.87801 1.02 down Mm.3496 Fnta 98121_at D49744 farnesyltransferase, CAAX box, alpha11449 0.87802 1.06 up Mm.2559 Umpk 101301_at L31784 uridine monophosphate kinase11450 0.87820 1.04 up Mm.218657 Cla3 97556_at AI843178 cerebellar ataxia 311451 0.87853 1.06 up Mm.46533 1110007L15Rik 99447_at AI021178 RIKEN cDNA 1110007L15 gene11452 0.87858 1.08 down Mm.39092 Kcnc3 92347_at X60796 potassium voltage gated channel, Shaw-related subfamily, member 311453 0.87864 1.04 down Mm.28037 1700040I03Rik 95619_at AI851723 RIKEN cDNA 1700040I03 gene11454 0.87884 1.10 up Mm.22680 Celsr1 103516_at AF031572 cadherin EGF LAG seven-pass G-type receptor 111455 0.87884 1.07 down Mm.544 Pea15 100548_at L31958 phosphoprotein enriched in astrocytes 1511456 0.87887 1.03 up Mm.18347 Psmd7 103350_at M64641 proteasome (prosome, macropain) 26S subunit, non-ATPase, 711457 0.87890 1.02 down Mm.16193 Muc1 102918_at M84683 mucin 1, transmembrane11458 0.87894 1.06 down Mm.28129 C77647 161005_at AI835776 expressed sequence C7764711459 0.87894 1.11 up Mm.1325 Foxb1 94687_at U90538 forkhead box B111460 0.87912 1.08 up Mm.56946 Pou3f4 99386_at M88301 POU domain, class 3, transcription factor 411461 0.87922 1.06 up Mm.20770 Cyp2a12 103670_at L06463 cytochrome P450, 2a1211462 0.87927 1.06 down Mm.57009 Eat2 101343_at AF020263 EWS/FLI1 activated transcript 211463 0.87940 1.04 down Mm.22171 Cnn3 160150_f_at AW125626 calponin 3, acidic11464 0.87943 1.02 down Mm.21162 Grim19-pending 93764_at AI854527 genes associated with retinoid-IFN-induced mortality 1911465 0.87945 1.05 down Mm.29644 AI173274 104464_s_at AI642389 expressed sequence AI17327411466 0.87971 1.04 up Mm.29088 0610013D04Rik 102689_at AF110520 RIKEN cDNA 0610013D04 gene11467 0.87995 1.08 up Mm.2209 Cd4 104667_at AC002397 CD4 antigen11468 0.88024 1.08 up Mm.1386 Prop1 100698_at U77946 paired like homeodomain factor 111469 0.88036 1.10 up Mm.971 Plg 161626_f_at AV028204 plasminogen11470 0.88051 1.08 up Mm.6838 Crygb 161780_f_at AV360800 crystallin, gamma B11471 0.88069 1.07 up 97010_at X8265511472 0.88076 1.04 down Mm.43482 D6Wsu147e 161148_f_at AV222766 DNA segment, Chr 6, Wayne State University 147, expressed11473 0.88092 1.05 up Mm.8 Usf1 93656_g_at X95316 upstream transcription factor 111474 0.88103 1.03 down Mm.6355 Ptp4a2 100595_at AF035644 protein tyrosine phosphatase 4a211475 0.88104 1.05 up Mm.11 Myf6 102265_at X59060 myogenic factor 611476 0.88114 1.07 up Mm.3113 p 97082_at M97900 pink-eyed dilution11477 0.88132 1.07 up Mm.3264 Txk 162137_f_at AV380810 TXK tyrosine kinase11478 0.88152 1.05 down Mm.12177 Arntl 102382_at AB014494 aryl hydrocarbon receptor nuclear translocator-like11479 0.88158 1.08 up Mm.37210 Ap1g1 92288_at X54424 adaptor protein complex AP-1, gamma 1 subunit11480 0.88161 1.15 down Mm.16620 Gad1 103061_at Z49976 glutamic acid decarboxylase 111481 0.88175 1.07 down Mm.157907 Cd1d2 101896_at M63697 CD1d2 antigen11482 0.88182 1.05 down Mm.2645 Eef1a2 94429_at L26479 eukaryotic translation elongation factor 1 alpha 211483 0.88255 1.04 down Mm.200627 3110001A13Rik 96640_at AI644158 RIKEN cDNA 3110001A13 gene11484 0.88261 1.04 up Mm.423 Mm.423 104396_at AI019327 ESTs, Weakly similar to AF171875 1 g1-related zinc finger protein [M.muscu11485 0.88274 1.05 down Mm.3373 Cfl2 97549_at L29468 cofilin 2, muscle11486 0.88277 1.08 up Mm.4791 Ereg 161158_f_at AV231492 epiregulin11487 0.88286 1.06 up Mm.32074 Kcnn1 97100_at AI854248 potassium intermediate/small conductance calcium-activated channel, subfa11488 0.88288 1.06 up Mm.1385 Pitx2 102788_s_at U70132 paired-like homeodomain transcription factor 211489 0.88332 1.05 up Mm.20910 Cpd 160655_at D85391 carboxypeptidase D11490 0.88349 1.04 up Mm.28540 1810043O07Rik 98889_at AI060923 RIKEN cDNA 1810043O07 gene11491 0.88351 1.03 down Mm.28552 Mm.28552 98896_at AW122980 Mus musculus, Similar to hypothetical protein FLJ20400, clone MGC:2810411492 0.88358 1.08 up Mm.174751 1700007D05Rik 97107_at AA162144 RIKEN cDNA 1700007D05 gene11493 0.88361 1.08 down Mm.196000 Col18a1 101881_g_at L22545 procollagen, type XVIII, alpha 111494 0.88368 1.05 up Mm.4610 Upp 161325_at AV102624 uridine phosphorylase11495 0.88370 1.08 up Mm.5043 Fos 161716_at AV252296 FBJ osteosarcoma oncogene11496 0.88370 1.07 up Mm.4339 Lama5 161702_f_at AV236263 laminin, alpha 511497 0.88418 1.12 up Mm.4984 Myf5 101162_at X56182 myogenic factor 511498 0.88425 1.05 up Mm.12846 Slc22al2 102429_at AB005451 solute carrier family 22 (organic cation transporter)-like 211499 0.88461 1.03 up Mm.20801 Htatip2 103671_at AF061972 HIV-1 tat interactive protein 2, 30 kDa homolog (human)11500 0.88462 1.04 up Mm.29264 1110008F13Rik 160333_at AI846102 RIKEN cDNA 1110008F13 gene11501 0.88507 1.06 down Mm.200975 Serf2 92618_at AW125253 small EDRK-rich factor 211502 0.88514 1.09 down Mm.29996 Cdo1 96346_at AI854020 cysteine dioxygenase 1, cytosolic11503 0.88528 1.06 up Mm.3963 Elf3 99059_at AF016294 E74-like factor 311504 0.88536 1.05 down Mm.21613 Ptk2b 103451_at AI835159 protein tyrosine kinase 2 beta11505 0.88538 1.07 up Mm.27969 AA420407 97281_at AI843141 expressed sequence AA42040711506 0.88563 1.05 down Mm.148693 Dazap1 97372_at AA880432 DAZ associated protein 111507 0.88573 1.10 up Mm.35089 Prcc 92250_s_at AA089181 papillary renal cell carcinoma (translocation-associated)11508 0.88577 1.03 down Mm.17500 Grb7 103095_at M94450 growth factor receptor bound protein 711509 0.88588 1.06 up Mm.4100 Cd7 92406_at D31956 CD7 antigen11510 0.88600 1.06 down Mm.28396 Tcf3 160780_at AJ223069 transcription factor 311511 0.88615 1.03 down Mm.29760 Psmd13 95742_at AW045451 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1311512 0.88630 1.04 down Mm.732 1110001H19Rik 101084_f_at AI527477 RIKEN cDNA 1110001H19 gene11513 0.88640 1.04 up Mm.22266 Tex264 94226_at AW048306 <strong>test</strong>is expressed gene 26411514 0.88657 1.05 up Mm.840 Emu1-pending 93689_at AW122071 Emu1 gene11515 0.88658 1.04 down Mm.12962 Gdap3 92826_at Y17852 ganglioside-induced differentiation-associated-protein 311516 0.88675 1.04 down Mm.57335 1200013P10Rik 160751_i_at AA216808 RIKEN cDNA 1200013P10 gene11517 0.88682 1.04 up Mm.181740 Ifrd2 104760_at AI838527 interferon-related developmental regulator 211518 0.88685 1.06 up Mm.40599 Odz2 92389_at AB025411 odd Oz/ten-m homolog 2 (Drosophila)11519 0.88700 1.02 up Mm.30150 1010001M12Rik 96915_f_at AA879764 RIKEN cDNA 1010001M12 gene11520 0.88706 1.04 down Mm.20225 Nfkb2 103614_at AW047899 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p10Page 128 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description11521 0.88729 1.05 down Mm.24003 AW061234 103697_at AW061234 expressed sequence AW06123411522 0.88739 1.03 down Mm.21705 1110049G11Rik 104077_at AW121992 RIKEN cDNA 1110049G11 gene11523 0.88772 1.08 up Mm.87779 Klk1 95775_f_at V00829 kallikrein 111524 0.88774 1.06 down Mm.12975 Mycbp 102766_at AB015858 c-myc binding protein11525 0.88781 1.06 down Mm.29807 Uchl1 96244_at AB025313 ubiquitin carboxy-terminal hydrolase L111526 0.88782 1.06 up Mm.42152 Fmnl 92482_at AF006466 formin-like11527 0.88790 1.03 down Mm.22230 1810060D16Rik 104279_at AW125116 RIKEN cDNA 1810060D16 gene11528 0.88803 1.05 down Mm.24417 AI842353 160971_at AI842353 expressed sequence AI84235311529 0.88813 1.06 down Mm.6761 Mm.6761 101661_r_at AA420337 EST11530 0.88819 1.05 up Mm.2772 Myh8 162374_r_at AV242220 myosin, heavy polypeptide 8, skeletal muscle, perinatal11531 0.88823 1.06 up Mm.14802 H19 93028_at X58196 H19 fetal liver mRNA11532 0.88829 1.07 down Mm.6456 Pftk1 93422_at U62391 PFTAIRE protein kinase 111533 0.88834 1.03 up Mm.34519 Lep 98443_at AI882416 leptin11534 0.88835 1.03 down Mm.30248 Mm.30248 162134_r_at AV379809 Mus musculus, clone IMAGE:3589087, mRNA, partial cds11535 0.88836 1.07 up Mm.6206 Kcnmb1 99832_at AF035045 potassium large conductance calcium-activated channel, subfamily M, beta m11536 0.88837 1.08 up Mm.193035 Rad9 93522_at AF045663 RAD9 homolog (S. pombe)11537 0.88861 1.08 down Mm.42024 Orc1 92458_at AJ003133 origin recognition complex, subunit 1 homolog (S. cerevisiae)11538 0.88885 1.11 up Mm.22338 Mm.22338 161782_r_at AV362004 Mus musculus, Similar to hypothetical protein FLJ20984, clone MGC:2919411539 0.88890 1.06 down Mm.140186 Eif4ebp2 94353_at U75530 eukaryotic translation initiation factor 4E binding protein 211540 0.88891 1.15 down Mm.4142 Ttgn1 161724_r_at AV265029 trans-golgi network protein 111541 0.88907 1.05 down Mm.180102 2810410A08Rik 92191_at AI255450 RIKEN cDNA 2810410A08 gene11542 0.88932 1.04 down Mm.16224 Guca1a 103038_at L36860 guanylate cyclase activator 1a (retina)11543 0.88936 1.02 down Mm.22162 2700027J02Rik 94081_at AW124390 RIKEN cDNA 2700027J02 gene11544 0.88940 1.05 up Mm.42094 Nespl-pending 102082_at AF107847 neuroendocrine secretory protein-like11545 0.88945 1.06 down Mm.2580 Sdc1 96033_at Z22532 syndecan 111546 0.89000 1.04 down Mm.4065 AI426465 99451_at AW060510 expressed sequence AI42646511547 0.89010 1.04 down Mm.104919 Bcas2 95061_at AI838996 breast carcinoma amplified sequence 211548 0.89018 1.06 up Mm.153729 2210010C04Rik 101336_at AE000663 RIKEN cDNA 2210010C04 gene11549 0.89036 1.02 up Mm.28753 1500010M16Rik 98953_at AW048032 RIKEN cDNA 1500010M16 gene11550 0.89049 1.03 down Mm.4370 D0HXS9928E 92649_at Y18505 DNA segment, human DXS9928E11551 0.89057 1.06 up Mm.5085 Six4 93000_g_at D50416 sine oculis-related homeobox 4 homolog (Drosophila)11552 0.89059 1.03 up Mm.2209 Cd4 94206_at AC002397 CD4 antigen11553 0.89089 1.11 up Mm.4443 Cyp1b1 161368_r_at AV237975 cytochrome P450, 1b1, benz[a]anthracene inducible11554 0.89105 1.04 up Mm.7196 6330407G04Rik 101392_at AW122839 RIKEN cDNA 6330407G04 gene11555 0.89113 1.07 up Mm.24403 Mm.24403 161214_r_at AV265258 ESTs, Weakly similar to B24264 proline-rich protein MP3 - mouse [M.muscu11556 0.89129 1.09 up Mm.104747 Igk-V28 93226_i_at Z70661 immunoglobulin kappa chain variable 28 (V28)11557 0.89132 1.05 up Mm.3994 3830417M17Rik 161181_f_at AV234570 RIKEN cDNA 3830417M17 gene11558 0.89139 1.05 up Mm.13854 Eya1 94706_s_at AI327488 eyes absent 1 homolog (Drosophila)11559 0.89142 1.06 down Mm.2681 Hfe 104014_at Y12650 hemochromatosis11560 0.89150 1.06 up Mm.88824 Or83 96984_at AB030894 gene for odorant receptor MOR8311561 0.89165 1.05 up Mm.2863 Itm1 98922_at L34260 intergral membrane protein 111562 0.89196 1.04 up Mm.196605 Hk1 99335_at J05277 hexokinase 111563 0.89208 1.04 up Mm.954 2410153K17Rik 101942_at AA839050 RIKEN cDNA 2410153K17 gene11564 0.89235 1.07 up Mm.5030 Gkap42-pending 161833_r_at AV309794 42 kD cGMP-dependent protein kinase anchoring protein11565 0.89241 1.03 down Mm.5181 Rnf19 100509_at AW121012 ring finger protein (C3HC4 type) 1911566 0.89246 1.04 down Mm.34372 Krtap12-1 92215_at AF081797 keratin associated protein 12-111567 0.89252 1.06 down Mm.2994 Rbl1 104476_at U27177 retinoblastoma-like 1 (p107)11568 0.89263 1.02 up Mm.22001 Dpm2 161349_f_at AV151975 dolichol-phosphate (beta-D) mannosyltransferase 211569 0.89264 1.07 up Mm.4909 Cbfa2t1h 98371_at AF052219 CBFA2T1 identified gene homolog (human)11570 0.89273 1.06 down Mm.34828 Hsp105 98111_at L40406 heat shock protein, 105 kDa11571 0.89274 1.03 down Mm.25149 Usp14 96061_at AW060186 ubiquitin specific protease 1411572 0.89337 1.08 up Mm.9213 Esr1 93947_g_at AA755982 estrogen receptor 1 (alpha)11573 0.89349 1.02 down Mm.688 Bag1 160540_at AF022223 Bcl2-associated athanogene 111574 0.89367 1.06 up Mm.1480 Ephb6 102871_at L77867 Eph receptor B611575 0.89403 1.05 up Mm.34519 Lep 98444_g_at AI882416 leptin11576 0.89425 1.07 down Mm.28362 AI326478 101745_f_at X94422 expressed sequence AI32647811577 0.89437 1.02 up Mm.215011 AI844780 95910_f_at AI844780 expressed sequence AI84478011578 0.89452 1.02 up Mm.34102 Odc 160084_at M12330 ornithine decarboxylase, structural11579 0.89455 1.02 up Mm.30929 Prdx1 97758_at AB023564 peroxiredoxin 111580 0.89455 1.03 down Mm.3160 Uros 97993_at U04439 uroporphyrinogen III synthase11581 0.89462 1.07 down Mm.443 Mthfd2 161478_at AV050090 methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetra11582 0.89501 1.02 up Mm.6678 Ptpn9 100976_at AF013490 protein tyrosine phosphatase, non-receptor type 911583 0.89511 1.08 down Mm.17322 Slc22a2 102947_at AJ006036 solute carrier family 22 (organic cation transporter), member 211584 0.89525 1.04 down Mm.16415 Mmp8 94769_at U96696 matrix metalloproteinase 811585 0.89531 1.04 down Mm.177272 Brp17 103636_at AI840971 brain protein 1711586 0.89531 1.02 up 100723_f_at AJ00556311587 0.89543 1.05 up Mm.1382 Krt2-17 101698_f_at AI852429 keratin complex 2, basic, gene 1711588 0.89546 1.07 up Mm.1339 Chgb 92841_f_at X51429 chromogranin B11589 0.89564 1.08 down Mm.4170 Ptgfr 97769_at D17433 prostaglandin F receptor11590 0.89584 1.05 down Mm.31883 AI447669 100314_f_at AI838036 expressed sequence AI44766911591 0.89598 1.03 down Mm.27499 2010004E11Rik 160235_at AI843521 RIKEN cDNA 2010004E11 gene11592 0.89603 1.04 down Mm.2478 Sfrs4 102093_f_at AI461979 splicing factor, arginine/serine-rich 4 (SRp75)11593 0.89604 1.09 down Mm.142716 Fabp6 160886_i_at AV063979 fatty acid binding protein 6, ileal (gastrotropin)11594 0.89605 1.08 up Mm.200775 Tgfbr3 102637_at AF039601 transforming growth factor, beta receptor III11595 0.89623 1.03 up Mm.1022 Cdc42 94105_at L78075 cell division cycle 42 homolog (S. cerevisiae)11596 0.89627 1.08 up Mm.1951 Rnps1 161773_i_at AV357125 ribonucleic acid binding protein S111597 0.89651 1.04 up Mm.22629 Krt2-6a 104369_at AB012033 keratin complex 2, basic, gene 6a11598 0.89658 1.07 down Mm.86423 Foxf1a 93704_at L35949 forkhead box F1a11599 0.89664 1.08 up Mm.22109 2610204L23Rik 94069_r_at AW230066 RIKEN cDNA 2610204L23 gene11600 0.89679 1.04 up Mm.17436 AW537030 103092_at AW124316 expressed sequence AW53703011601 0.89684 1.13 down Mm.7486 Bmp2 161118_r_at AV333272 bone morphogenetic protein 211602 0.89694 1.05 up Mm.44065 Cx3cr1 95335_at AF074912 chemokine (C-X3-C) receptor 111603 0.89705 1.02 up Mm.22123 D15Wsu75e 162438_f_at AV345874 DNA segment, Chr 15, Wayne State University 75, expressed11604 0.89708 1.02 down Mm.22731 Itgb4bp 94826_at Y11460 integrin beta 4 binding protein11605 0.89737 1.03 down Mm.14155 Mm.14155 102807_at AW048054 ESTs, Weakly similar to EG:152A3.5 [D.melanogaster]11606 0.89737 1.03 up Mm.29712 0610009D07Rik 95714_at AI226264 RIKEN cDNA 0610009D07 gene11607 0.89739 1.03 down Mm.22623 AV005629 160161_at AI849497 expressed sequence AV00562911608 0.89785 1.04 down Mm.7103 Pbx2 102206_at AF030001 pre B-cell leukemia transcription factor 211609 0.89795 1.07 up Mm.21629 Abcf2 93845_at AI837318 ATP-binding cassette, sub-family F (GCN20), member 211610 0.89798 1.04 up Mm.4054 Tbxas1 92387_at L18868 thromboxane A synthase 1, plateletPage 129 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description11611 0.89810 1.04 down Mm.5357 AI447490 93175_at AI049206 EST AI44749011612 0.89823 1.07 up Mm.4489 Kcnh1 98380_at U04294 potassium voltage-gated channel, subfamily H (eag-related), member 111613 0.89827 1.05 up Mm.21881 TOB3 161322_r_at AV093783 TOB311614 0.89847 1.12 down Mm.24488 4933407C03Rik 162239_at AV329526 RIKEN cDNA 4933407C03 gene11615 0.89861 1.04 up Mm.196075 Acate3-pending 94850_at AJ238894 acyl-Coenzyme A thioesterase 3, mitochondrial11616 0.89865 1.04 up Mm.5117 Mm.5117 93130_at AW122860 ESTs, Weakly similar to Y179_HUMAN HYPOTHETICAL PROTEIN KIAA0111617 0.89876 1.03 down Mm.182194 1190017B18Rik 95418_at AI848851 RIKEN cDNA 1190017B18 gene11618 0.89877 1.03 down Mm.1147 Calm3 93293_at M27844 calmodulin 311619 0.89882 1.06 down Mm.14413 Cyp2b13 102820_at M60358 cytochrome P450, 2b13, phenobarbitol inducible, type c11620 0.89888 1.03 down Mm.21103 D7Wsu128e 103861_s_at AA388099 DNA segment, Chr 7, Wayne State University 128, expressed11621 0.89909 1.04 up Mm.1025 Nfe2l2 92562_at U70475 nuclear, factor, erythroid derived 2, like 211622 0.89915 1.08 up Mm.39089 Bmpr1b 97725_at Z23143 bone morphogenetic protein receptor, type 1B11623 0.89919 1.04 down Mm.225 Mm.225 161099_at AA285978 ESTs11624 0.89934 1.06 up Mm.4325 Klf4 161185_i_at AV235936 Kruppel-like factor 4 (gut)11625 0.89940 1.05 up 99428_at X0474811626 0.89947 1.06 up Mm.21882 Cd84 104228_at AA607237 CD84 antigen11627 0.89956 1.09 down Mm.1385 Pitx2 161340_r_at AV132499 paired-like homeodomain transcription factor 211628 0.89959 1.05 up Mm.116 H2-Oa 103616_at AF100956 histocompatibility 2, O region alpha locus11629 0.89968 1.04 down Mm.29625 Mm.29625 160813_r_at AI893329 ESTs, Weakly similar to COXG MOUSE CYTOCHROME C OXIDASE POLY11630 0.89976 1.06 down Mm.1764 Gabpb1 103318_at M74516 GA repeat binding protein, beta 111631 0.89984 1.08 down Mm.44170 Vdr 99964_at AW061016 vitamin D receptor11632 0.90015 1.06 up Mm.20930 Mkln1 103831_at U72194 muskelin 1, intracellular mediator containing kelch motifs11633 0.90018 1.08 up Mm.1340 Mm.1340 100692_at X16301 M.musculus RNA for 18.8 family from nasopharyngeal carcinoma tumour11634 0.90026 1.04 up Mm.5159 Apbb2 160903_at U70210 amyloid beta (A4) precursor protein-binding, family B, member 211635 0.90039 1.04 down 96526_at AW22884011636 0.90056 1.08 up Mm.1397 Smr2 102684_at U82375 submaxillary gland androgen regulated protein 211637 0.90095 1.04 down Mm.29432 1110018O08Rik 95138_at AI836568 RIKEN cDNA 1110018O08 gene11638 0.90100 1.05 down Mm.19804 Spg4 103585_at AI851408 spastic paraplegia 4 homolog (human)11639 0.90115 1.01 up Mm.29689 Mm.29689 97366_at AI851024 Mus musculus, similar to integral inner nuclear membrane protein, clone MG11640 0.90133 1.03 down Mm.34332 LOC56628 97125_f_at M58156 MHC (A.CA/J(H-2K-f) class I antigen11641 0.90142 1.03 up Mm.24042 1210001E11Rik 160182_at AI846595 RIKEN cDNA 1210001E11 gene11642 0.90155 1.06 down Mm.21446 1190008F14Rik 93806_at AI848671 RIKEN cDNA 1190008F14 gene11643 0.90163 1.04 up Mm.40749 Mm.40749 97751_f_at AI835771 ESTs, Moderately similar to G3P MOUSE GLYCERALDEHYDE 3-PHOSPHA11644 0.90187 1.03 up Mm.21414 Ccsd 103909_at AI839702 copper chaperone for superoxide dismutase11645 0.90209 1.03 down Mm.28414 Mm.28414 97892_at AI844732 Mus musculus, clone MGC:38352 IMAGE:5344340, mRNA, complete cds11646 0.90213 1.04 down Mm.41665 1110025J15Rik 99160_s_at AW227647 RIKEN cDNA 1110025J15 gene11647 0.90236 1.06 down Mm.41447 4432404A22Rik 92425_at AW122559 RIKEN cDNA 4432404A22 gene11648 0.90246 1.05 up Mm.46809 Vipr1 98777_at AB022860 vasoactive in<strong>test</strong>inal peptide receptor 111649 0.90249 1.05 down Mm.22688 tsg101 94809_at U52945 tumor susceptibility gene 10111650 0.90252 1.02 up Mm.183257 AA617397 99120_f_at R75450 EST AA61739711651 0.90272 1.03 down Mm.27545 Hrmt1l2 96696_at AI837110 heterogeneous nuclear ribonucleoproteins methyltransferase-like 2 (S. cerev11652 0.90279 1.03 up Mm.323 Pdcd2 160412_at U10903 programmed cell death 211653 0.90284 1.08 up Mm.196407 Igk-V21 101641_at M86751 immunoglobulin kappa chain variable 21 (V21)11654 0.90285 1.09 down Mm.27065 Chp-pending 162119_r_at AV370870 calcium binding protein P2211655 0.90304 1.07 up Mm.203936 4921532K09Rik 98958_at AA759910 RIKEN cDNA 4921532K09 gene11656 0.90306 1.04 up Mm.4809 Pgf 92909_at X80171 placental growth factor11657 0.90312 1.05 down Mm.153185 Syngr4 99531_at AJ011734 synaptogyrin 411658 0.90343 1.05 down Mm.14115 Ets1 94720_at M58482 E26 avian leukemia oncogene 1, 5' domain11659 0.90347 1.04 down Mm.143141 Eif1a 93058_at AF026481 eukaryotic translation initiation factor 1A11660 0.90353 1.04 down Mm.17493 Cradd 102951_at AJ224738 CASP2 and RIPK1 domain containing adaptor with death domain11661 0.90356 1.04 up Mm.206842 C76213 97666_r_at C76213 expressed sequence C7621311662 0.90356 1.03 up Mm.56926 0610037M15Rik 98438_f_at X16202 RIKEN cDNA 0610037M15 gene11663 0.90369 1.10 up Mm.4055 Mm.4055 162029_r_at AV366522 Mus musculus, clone IMAGE:5102177, mRNA, partial cds11664 0.90379 1.05 up Mm.4795 Tcfap2b 92903_at X78197 transcription factor AP-2 beta11665 0.90400 1.05 down Mm.30120 1810034D23Rik 160389_r_at AW045247 RIKEN cDNA 1810034D23 gene11666 0.90409 1.06 down Mm.1453 Adam1 162063_f_at AV276734 a disintegrin and metalloproteinase domain 1a (fertilin alpha)11667 0.90410 1.08 up Mm.104932 Btg4 98583_at AJ005120 B-cell translocation gene 411668 0.90431 1.07 up Mm.2209 Cd4 97998_at AC002397 CD4 antigen11669 0.90445 1.04 up Mm.26722 Ndr2 161610_at AV349686 N-myc downstream regulated 211670 0.90447 1.09 down Mm.44326 D19397 100704_at D19397 expressed sequence D1939711671 0.90469 1.03 down Mm.28343 1810019E15Rik 160286_at AA733594 RIKEN cDNA 1810019E15 gene11672 0.90469 1.07 down Mm.9445 Gucy1b3 93954_at AF020339 guanylate cyclase 1, soluble, beta 311673 0.90473 1.04 up Mm.20950 Dby 103842_at AJ007376 DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide, Y chromoso11674 0.90519 1.06 up Mm.46801 Mm.46801 97569_at AF045028 M.musculus mRNA (2F7) for IgA V-D-J-heavy chain11675 0.90535 1.02 down Mm.626 Psme2 100588_at U60329 proteasome (prosome, macropain) 28 subunit, beta11676 0.90545 1.06 down Mm.10563 Mtf2 102069_at S78454 metal response element binding transcription factor 211677 0.90560 1.07 up Mm.212192 Mm.212192 100749_at AA414976 ESTs11678 0.90562 1.03 up Mm.23095 Chrac1 100126_at AA967263 chromatin accessibility complex 111679 0.90584 1.07 up Mm.7522 Folh1 93629_s_at AF026380 folate hydrolase11680 0.90606 1.06 up Mm.10731 Ubr1 102247_at AF061555 ubiquitin protein ligase E3 component n-recognin 111681 0.90644 1.04 down Mm.24096 Thbd 162023_f_at AV364086 thrombomodulin11682 0.90645 1.02 down Mm.21707 1110021N07Rik 93982_at AW122476 RIKEN cDNA 1110021N07 gene11683 0.90661 1.02 down Mm.218595 Mm.218595 93572_at AI835051 Mus musculus, clone MGC:19199 IMAGE:4236882, mRNA, complete cds11684 0.90671 1.02 down Mm.28591 Lias 98909_at AW060843 lipoic acid synthetase11685 0.90673 1.05 up Mm.14722 Ywhaq 93016_at U56243 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,11686 0.90722 1.03 up Mm.29914 Mm.29914 97406_at AW122258 ESTs11687 0.90728 1.02 up Mm.196080 AA408877 160776_at AW048886 expressed sequence AA40887711688 0.90739 1.04 up Mm.23935 AI507382 104503_at AI563623 expressed sequence AI50738211689 0.90798 1.04 up Mm.21534 Ilf2 93823_at AI844864 interleukin enhancer binding factor 211690 0.90803 1.06 up Mm.89110 5031401C21Rik 162054_r_at AV267746 RIKEN cDNA 5031401C21 gene11691 0.90841 1.02 down Mm.7472 Dcra 101104_at AB001990 Down syndrome critical region gene a11692 0.90858 1.08 down Mm.200406 Mm.200406 92687_at AA097203 Mus musculus, Similar to SWI/SNF related, matrix associated, actin depende11693 0.90868 1.02 down Mm.16766 Prkacb 93116_at J02626 protein kinase, cAMP dependent, catalytic, beta11694 0.90883 1.04 down Mm.843 Lrmp 101835_at U10484 lymphoid-restricted membrane protein11695 0.90916 1.03 up Mm.2151 Cox7a3 93820_at AF037371 cytochrome c oxidase, subunit VIIa 311696 0.90918 1.03 up Mm.20453 Fkbp1b 103248_at AF060872 FK506 binding protein 1b (12.6 kDa)11697 0.90921 1.03 down Mm.117992 AA517758 103300_at AW124239 expressed sequence AA51775811698 0.90926 1.05 down Mm.200919 AI450287 161088_r_at AV171460 expressed sequence AI45028711699 0.90935 1.03 down Mm.28489 AA673511 160296_at AF033188 expressed sequence AA67351111700 0.90947 1.02 up Mm.143141 Eif1a 103708_at AI132207 eukaryotic translation initiation factor 1APage 130 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description11701 0.90950 1.05 down Mm.203746 AW122239 103462_at AW122239 expressed sequence AW12223911702 0.90951 1.03 down Mm.12236 Zfp207 92771_at AB013357 zinc finger protein 20711703 0.90957 1.07 down Mm.196345 Ysg2 103933_at U61183 yolk sac gene 211704 0.90983 1.04 up Mm.143762 Jph3 93374_at AI836349 junctophilin 311705 0.91019 1.03 down Mm.24883 1110058B13Rik 160197_at AW060487 RIKEN cDNA 1110058B13 gene11706 0.91023 1.06 up Mm.4257 Aldh3a1 99548_at AF033034 aldehyde dehydrogenase family 3, subfamily A111707 0.91030 1.02 down Mm.24637 LOC192195 103763_at AW121855 putative chromatin remodeling factor11708 0.91047 1.05 up Mm.27568 6530403D07Rik 161396_f_at AV271976 RIKEN cDNA 6530403D07 gene11709 0.91048 1.04 up Mm.2478 Sfrs4 104754_at AI853032 splicing factor, arginine/serine-rich 4 (SRp75)11710 0.91050 1.05 up Mm.188567 Mm.188567 102112_s_at AU040583 EST11711 0.91072 1.04 up Mm.1614 F2rl1 102915_at Z48043 coagulation factor II (thrombin) receptor-like 111712 0.91081 1.05 down Mm.32 Mm.32 104666_at AW046904 ESTs, Weakly similar to I48724 zinc finger protein PZF - mouse [M.musculus11713 0.91101 1.04 up Mm.153899 Adar 96188_at AF052506 adenosine deaminase, RNA-specific11714 0.91108 1.05 up Mm.156616 Rnf42 95156_g_at AI853875 ring finger protein 4211715 0.91143 1.03 down Mm.25146 Mm.25146 103932_at AA655311 ESTs, Highly similar to DKFZP564O0463 protein; HSPC064 protein [Homo11716 0.91168 1.02 down Mm.5769 D2Ertd217e 93232_at AI843108 DNA segment, Chr 2, ERATO Doi 217, expressed11717 0.91168 1.08 up Mm.99117 Mm.99117 162212_at AV379327 EST11718 0.91172 1.07 up Mm.1493 Sox10 100283_at AW125812 SRY-box containing gene 1011719 0.91200 1.04 up Mm.10698 Ap1g2 92594_at AF068707 adaptor protein complex AP-1, gamma 2 subunit11720 0.91223 1.07 up Mm.28577 1110006I11Rik 98903_at W41966 RIKEN cDNA 1110006I11 gene11721 0.91233 1.05 down Mm.25117 BC004022 103930_at AI413179 hypothetical protein, MGC:760711722 0.91236 1.04 up Mm.18072 Crcp 103334_at AF028242 calcitonin gene-related peptide-receptor component protein11723 0.91255 1.03 up Mm.24210 Bcat2 100443_at AF031467 branched chain aminotransferase 2, mitochondrial11724 0.91256 1.06 down Mm.37348 Mm.37348 101690_r_at AI662095 EST11725 0.91268 1.05 up Mm.5507 C76554 99354_s_at C76558 expressed sequence C7655411726 0.91269 1.05 down Mm.2570 C1qb 162276_i_at AV367855 complement component 1, q subcomponent, beta polypeptide11727 0.91290 1.05 down Mm.1980 Hspb2 103214_at AW048883 heat shock 27kD protein 211728 0.91297 1.07 up Mm.19889 Krt1-16 103589_at AF053235 keratin complex 1, acidic, gene 1611729 0.91311 1.02 up Mm.2563 Esrra 103964_at U85259 estrogen related receptor, alpha11730 0.91312 1.03 up Mm.24661 AI327031 103765_at AA718040 expressed sequence AI32703111731 0.91319 1.03 down Mm.176 Tarbp2 103101_at U79962 TAR (HIV) RNA binding protein 211732 0.91322 1.04 down Mm.42249 Neo1 92518_at Y09535 neogenin11733 0.91322 1.02 down Mm.41574 Mrpl53 99153_at AI854607 mitochondrial ribosomal protein L5311734 0.91343 1.03 down Mm.29088 0610013D04Rik 95652_at AF110520 RIKEN cDNA 0610013D04 gene11735 0.91401 1.02 down Mm.21241 A930018B01Rik 103884_at AI850335 RIKEN cDNA A930018B01 gene11736 0.91403 1.02 up Mm.30118 Gcn5l1 97917_at Y13778 general control of amino acid synthesis-like 1 (yeast)11737 0.91412 1.05 down Mm.99123 9230102M18Rik 160564_at X81627 RIKEN cDNA 9230102M18 gene11738 0.91430 1.08 up Mm.140154 Svs5 98842_at X57139 seminal vesicle secretion 511739 0.91451 1.05 down Mm.4494 Pkp1 99996_at Y07941 plakophilin 111740 0.91462 1.02 up Mm.28787 Klf3 100011_at AI851658 Kruppel-like factor 3 (basic)11741 0.91484 1.05 up Mm.39085 Cry2 97724_at AB003433 cryptochrome 2 (photolyase-like)11742 0.91496 1.03 up Mm.21163 D7Ertd373e 103871_at AW123729 DNA segment, Chr 7, ERATO Doi 373, expressed11743 0.91504 1.08 up Mm.143501 Svs2 94639_at X91270 seminal vesicle protein, secretion 211744 0.91509 1.06 down Mm.8403 Acox1 162158_r_at AV338691 acyl-Coenzyme A oxidase 1, palmitoyl11745 0.91518 1.04 down Mm.219663 Fbln1 94308_at X70853 fibulin 111746 0.91538 1.09 down Mm.1303 Ppard 94198_at L28116 peroxisome proliferator activator receptor delta11747 0.91552 1.05 down Mm.22664 AA407235 102095_f_at AI842145 expressed sequence AA40723511748 0.91571 1.03 up Mm.1729 Gapds 102946_r_at U09964 glyceraldehyde-3-phosphate dehydrogenase, spermatogenic11749 0.91571 1.04 up Mm.27577 Mm.27577 96535_at AI595382 ESTs, Weakly similar to ZF26 MOUSE ZINC FINGER PROTEIN 26 [M.musc11750 0.91579 1.02 down Mm.30191 2600013G09Rik 96941_at AI854043 RIKEN cDNA 2600013G09 gene11751 0.91585 1.04 down Mm.1164 Sec61g 92636_f_at U11027 SEC61, gamma subunit (S. cerevisiae)11752 0.91586 1.02 down Mm.28981 Mm.28981 94512_f_at AI843210 Mus musculus, archain 1, clone MGC:27546 IMAGE:4480874, mRNA, comp11753 0.91596 1.02 up Mm.27184 1600017F22Rik 160998_at AV268207 RIKEN cDNA 1600017F22 gene11754 0.91598 1.04 up Mm.149029 Siat1 94431_at D16106 sialyltransferase 1 (beta-galactoside alpha-2,6-sialyltransferase)11755 0.91607 1.02 up Mm.29854 Hdac6 104471_at AF006603 histone deacetylase 611756 0.91608 1.09 up Mm.24932 C76940 95955_at AI606577 expressed sequence C7694011757 0.91617 1.03 down Mm.46812 H2-Q2 102161_f_at X58609 histocompatibility 2, Q region locus 211758 0.91639 1.03 up Mm.15621 Cftr 94757_at M60493 cystic fibrosis transmembrane conductance regulator homolog11759 0.91675 1.02 down Mm.44220 Tmem4 100039_at AW125880 transmembrane protein 411760 0.91696 1.05 down Mm.22372 2700038B03Rik 160685_at AI153037 RIKEN cDNA 2700038B03 gene11761 0.91704 1.02 down Mm.12819 Bckdhb 102302_at L16992 branched chain ketoacid dehydrogenase E1, beta polypeptide11762 0.91713 1.05 up Mm.10817 Xlkd1 160583_at AA880988 extra cellular link domain-containing 111763 0.91723 1.07 up Mm.10804 Gfi1b 102260_at AF017275 growth factor independent 1B11764 0.91742 1.05 down Mm.4050 Fxc1 99124_at AI854207 fractured callus expressed transcript 111765 0.91748 1.07 down Mm.196189 Angptl4 161518_r_at AV204242 angiopoietin-like 411766 0.91755 1.04 up Mm.4885 Yap 161308_f_at AV351558 yes-associated protein, 65 kDa11767 0.91776 1.04 down Mm.7526 Cugbp1 93630_at X61451 CUG triplet repeat, RNA binding protein 111768 0.91823 1.04 down Mm.29070 1810042K04Rik 162356_r_at AV211712 RIKEN cDNA 1810042K04 gene11769 0.91857 1.03 down Mm.4871 Timp3 160519_at U26437 tissue inhibitor of metalloproteinase 311770 0.91867 1.05 up Mm.1977 Epha3 95298_at M68513 Eph receptor A311771 0.91875 1.03 up Mm.4558 Yes 100015_at X67677 Yamaguchi sarcoma viral (v-yes) oncogene homolog11772 0.91885 1.05 up Mm.27743 5730454C12Rik 95553_at AW045452 RIKEN cDNA 5730454C12 gene11773 0.91896 1.04 down Mm.130 Cish1 92832_at U88325 cytokine inducible SH2-containing protein 111774 0.91913 1.06 down Mm.22322 Gna14 95364_at M80631 guanine nucleotide binding protein, alpha 1411775 0.91918 1.07 down Mm.2810 Chrng 95639_at X03818 cholinergic receptor, nicotinic, gamma polypeptide11776 0.91947 1.02 down Mm.68712 Fzd4 93459_s_at AW122897 frizzled homolog 4 (Drosophila)11777 0.91950 1.03 down Mm.4721 Gpcr3 98786_at D21062 G-protein coupled receptor 311778 0.91952 1.04 down Mm.27148 Gsg1 96620_at D87325 germ cell-specific gene 111779 0.91956 1.03 down Mm.180052 Ube2d2 93069_at U62483 ubiquitin-conjugating enzyme E2D 211780 0.91962 1.06 up Mm.4672 Gpr83 92734_at M80481 G protein-coupled receptor 8311781 0.91966 1.04 up Mm.90115 Lypla1 101946_at AA840463 lysophospholipase 111782 0.91967 1.04 up Mm.4657 Apba2 92727_at L34676 amyloid beta (A4) precursor protein-binding, family A, member 211783 0.91970 1.06 up Mm.27369 Hgfac 104182_at AI042655 hepatocyte growth factor activator11784 0.91974 1.04 up Mm.46815 Gja10 102164_at AJ010741 gap junction membrane channel protein alpha 1011785 0.91974 1.04 down Mm.6877 Ap2a1 101357_at X14971 adaptor protein complex AP-2, alpha 1 subunit11786 0.91982 1.03 up Mm.27853 D7Wsu180e 97249_at AW124204 DNA segment, Chr 7, Wayne State University 180, expressed11787 0.91996 1.03 up Mm.7964 Cdrap 101453_at X94322 cartilage derived retinoic acid sensitive protein11788 0.91998 1.03 down Mm.12956 Hcn2 94195_r_at AJ225122 hyperpolarization-activated, cyclic nucleotide-gated K+ 211789 0.92008 1.02 down Mm.2984 Silg41 160364_at X80232 silica-induced gene 4111790 0.92008 1.03 down Mm.206642 AA407964 95417_at AI117848 expressed sequence AA407964Page 131 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description11791 0.92016 1.02 up Mm.4923 Mm.4923 100466_f_at AA655823 ESTs11792 0.92046 1.05 up Mm.52490 Mm.52490 162453_at AV034993 EST11793 0.92066 1.03 down Mm.711 Tnnt1 161361_s_at AV213431 troponin T1, skeletal, slow11794 0.92104 1.02 down Mm.2146 Aup1 93809_at U41736 ancient ubiquitous protein11795 0.92120 1.03 down Mm.31255 Notch1 97497_at Z11886 Notch gene homolog 1, (Drosophila)11796 0.92124 1.03 down Mm.3003 Epim 104482_at D10475 epimorphin11797 0.92143 1.04 down Mm.56941 Olfr15 102170_at AL078630 olfactory receptor 1511798 0.92170 1.04 down Mm.87638 5730533P17Rik 104404_at AA693221 RIKEN cDNA 5730533P17 gene11799 0.92194 1.04 up Mm.56941 Olfr15 102169_at AL078630 olfactory receptor 1511800 0.92210 1.06 up Mm.27391 Mm.27391 161850_at AV053172 ESTs11801 0.92229 1.06 up Mm.1729 Gapds 160950_at AA497662 glyceraldehyde-3-phosphate dehydrogenase, spermatogenic11802 0.92230 1.02 up Mm.10153 Twg-pending 102032_at AW060819 twisted gastrulation protein11803 0.92240 1.03 down Mm.7247 Stxbp2 162272_r_at AV365041 syntaxin binding protein 211804 0.92254 1.03 down Mm.28518 Fn14-pending 94266_at AW121737 type I transmembrane protein Fn1411805 0.92265 1.03 up Mm.4841 Hsf1 100451_at AF059275 heat shock factor 111806 0.92265 1.05 up Mm.57033 Mm.57033 97564_f_at AF044077 M.musculus immunoglobulin kappa chain variable region11807 0.92286 1.06 down Mm.26991 H13 96116_at AW048017 histocompatibility 1311808 0.92291 1.04 up Mm.18535 Myef2 160626_at U13262 myelin basic protein expression factor 2, repressor11809 0.92300 1.04 down Mm.27343 Emcn-pending 93884_at AB034693 endomucin11810 0.92302 1.03 up Mm.200572 C76179 93184_at AI596362 expressed sequence C7617911811 0.92304 1.02 down Mm.200859 Pafah1b2 95404_at AW123453 platelet-activating factor acetylhydrolase, isoform 1b, alpha2 subunit11812 0.92312 1.05 down Mm.20764 Cyp2c29 93585_at D17674 cytochrome P450, 2c2911813 0.92332 1.04 down Mm.195451 Gosr2 99986_at AF007550 golgi SNAP receptor complex member 211814 0.92354 1.02 down Mm.21669 AL033311 93972_at AI837493 expressed sequence AL03331111815 0.92356 1.02 down Mm.17554 Rgs3 160747_at AI844739 regulator of G-protein signaling 311816 0.92362 1.05 up Mm.39725 Nttp1 92362_at X95518 neuronal tyrosine/threonine phosphatase 111817 0.92376 1.01 down Mm.25045 8030486F04Rik 95490_at AW120891 RIKEN cDNA 8030486F04 gene11818 0.92401 1.04 up Mm.5396 Sorl1 100888_at AB015790 sortilin-related receptor, LDLR class A repeats-containing11819 0.92428 1.03 up Mm.23207 5430432P15Rik 102912_at AI265115 RIKEN cDNA 5430432P15 gene11820 0.92450 1.04 up Mm.8752 Rem 93855_at U91601 rad and gem related GTP binding protein11821 0.92459 1.03 down Mm.27954 AI551216 95604_at AI843294 expressed sequence AI55121611822 0.92460 1.05 down Mm.42588 C81363 102111_f_at C81361 expressed sequence C8136311823 0.92469 1.02 down Mm.6800 Krt2-8 101009_at X15662 keratin complex 2, basic, gene 811824 0.92471 1.05 down Mm.831 Ssr4 101511_at X90582 signal sequence receptor, delta11825 0.92490 1.03 down Mm.7952 Peg3 161316_f_at AV353105 paternally expressed 311826 0.92492 1.04 up Mm.22339 AI551257 103499_at AI843063 expressed sequence AI55125711827 0.92494 1.02 down Mm.30210 Psma6 96952_at AW121552 proteasome (prosome, macropain) subunit, alpha type 611828 0.92504 1.04 down Mm.153405 Mm.153405 95393_at AI503362 Mus musculus, Similar to KIAA0952 protein, clone MGC:25591 IMAGE:401111829 0.92504 1.05 down Mm.1160 AI597080 161539_f_at AV237754 expressed sequence AI59708011830 0.92520 1.02 down Mm.16767 Hnrpa2b1 93117_at AF073993 heterogeneous nuclear ribonucleoprotein A2/B111831 0.92546 1.05 down Mm.15655 Lhx3 102902_at L38248 LIM homeobox protein 311832 0.92550 1.04 up Mm.227 1110004F14Rik 104385_i_at AI843901 RIKEN cDNA 1110004F14 gene11833 0.92556 1.02 up Mm.38450 9-Sep 98609_at AJ250723 septin 911834 0.92560 1.07 down Mm.6239 Pdyn 99840_at AF026537 prodynorphin11835 0.92574 1.04 up Mm.656 Rrm1 100612_at K02927 ribonucleotide reductase M111836 0.92602 1.01 down Mm.33907 1110003H18Rik 98037_at AW122782 RIKEN cDNA 1110003H18 gene11837 0.92623 1.02 down Mm.22533 Cnot2 94281_at AW125138 CCR4-NOT transcription complex, subunit 211838 0.92628 1.03 down Mm.26153 Rngtt 94416_at AF025653 RNA guanylyltransferase and 5'-phosphatase11839 0.92634 1.05 down Mm.7053 Mm.7053 161078_at AA607758 ESTs11840 0.92638 1.03 down Mm.1566 Atf5 103006_at AB012276 activating transcription factor 511841 0.92642 1.04 up Mm.59353 Prm3 93242_at Z47352 protamine 311842 0.92651 1.03 down Mm.39286 Cstf3 100968_at AW122609 cleavage stimulation factor, 3' pre-RNA, subunit 311843 0.92659 1.03 up Mm.4088 Ltc4s 92401_at U27195 leukotriene C4 synthase11844 0.92659 1.04 up Mm.174491 Myg1-pending 95651_at AI842612 melanocyte prolifeating gene 111845 0.92663 1.06 down Mm.4327 AA536730 161036_at AW124505 expressed sequence AA53673011846 0.92698 1.05 up Mm.104764 Xlr4 101884_at AI451153 X-linked lymphocyte-regulated 411847 0.92703 1.05 up Mm.28388 Tex20 96169_at AA683788 <strong>test</strong>is expressed gene 2011848 0.92716 1.05 up Mm.24733 Sema5a 103766_at X97817 sema domain, seven thrombospondin repeats (type 1 and type 1-like), transm11849 0.92721 1.04 up Mm.25061 Mm.25061 95995_at C80108 ESTs11850 0.92768 1.02 up Mm.24280 4921514G19Rik 95416_at AI642184 RIKEN cDNA 4921514G19 gene11851 0.92774 1.03 down Mm.6202 Sntb1 93384_at U89997 syntrophin, basic 111852 0.92782 1.05 down Mm.8359 Pklr 101471_at D63764 pyruvate kinase liver and red blood cell11853 0.92787 1.02 down Mm.28047 2310022K15Rik 95622_at AW123907 RIKEN cDNA 2310022K15 gene11854 0.92789 1.03 up Mm.19142 Cappa1 93499_at U16740 capping protein alpha 111855 0.92809 1.03 up Mm.3212 Mm.3212 161018_at AI661590 ESTs11856 0.92817 1.03 up Mm.20917 Rps6kb2 103825_at AJ007938 ribosomal protein S6 kinase, 70kD, polypeptide 211857 0.92817 1.03 up Mm.10223 4930563P03Rik 160576_at AW046003 RIKEN cDNA 4930563P03 gene11858 0.92823 1.07 down Mm.12396 Znfn1a1 102293_at L03547 zinc finger protein, subfamily 1A, 1 (Ikaros)11859 0.92826 1.02 up Mm.199871 AI447783 95400_i_at AI447783 expressed sequence AI44778311860 0.92838 1.04 down Mm.10110 Nkx2-9 96422_at Y15741 NK2 transcription factor related, locus 9 (Drosophila)11861 0.92844 1.05 up Mm.21105 AA407526 160956_r_at AA655804 expressed sequence AA40752611862 0.92845 1.02 down Mm.25581 5730406H10Rik 161715_f_at AV250651 RIKEN cDNA 5730406H10 gene11863 0.92853 1.02 down Mm.29666 Slc25a20 95695_at AB017112 solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), me11864 0.92858 1.01 down Mm.12386 4930553F24Rik 102396_at AW122840 RIKEN cDNA 4930553F24 gene11865 0.92858 1.03 up Mm.28367 AA408740 104053_at AA110657 expressed sequence AA40874011866 0.92861 1.03 down Mm.119265 C79715 96736_at AI850370 expressed sequence C7971511867 0.92888 1.04 down Mm.3174 Lifr 104658_at D17444 leukemia inhibitory factor receptor11868 0.92930 1.02 down Mm.7417 Ccnd3 160545_at M86183 cyclin D311869 0.92959 1.04 down Mm.28269 Ikbkb 93706_at AF026524 inhibitor of kappaB kinase beta11870 0.92962 1.04 up Mm.196219 1110018P21Rik 95497_at AI843880 RIKEN cDNA 1110018P21 gene11871 0.92975 1.06 up Mm.22777 Plf 161590_r_at AV290437 proliferin11872 0.92980 1.04 up Mm.896 Il1r1 93914_at M20658 interleukin 1 receptor, type I11873 0.92989 1.04 up Mm.3050 2900060B22Rik 96590_f_at AI845283 RIKEN cDNA 2900060B22 gene11874 0.93012 1.05 down Mm.3130 Kif4 104644_at D12646 kinesin heavy chain member 411875 0.93019 1.05 up Mm.23979 Mm.23979 95884_at AI449297 ESTs11876 0.93020 1.02 up Mm.29476 AA408783 95153_at AI845988 expressed sequence AA40878311877 0.93021 1.02 down Mm.4651 Kifap3 100113_s_at D50367 kinesin-associated protein 311878 0.93022 1.04 up Mm.34312 Tuba3 160420_r_at M13442 tubulin alpha 311879 0.93028 1.02 down Mm.157907 Cd1d2 101897_g_at M63697 CD1d2 antigen11880 0.93029 1.04 down Mm.142364 Star 161784_f_at AV362816 steroidogenic acute regulatory proteinPage 132 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description11881 0.93053 1.03 up Mm.464 4921531G14Rik 100400_at AW124329 RIKEN cDNA 4921531G14 gene11882 0.93107 1.05 up Mm.5226 T25656 101206_at T25656 expressed sequence T2565611883 0.93145 1.04 down Mm.20844 AF073881 103799_at AF073881 expressed sequence AF07388111884 0.93146 1.01 up Mm.3882 Bcl2l 99027_at L35049 Bcl2-like11885 0.93162 1.03 down Mm.27979 Mela 93860_i_at M17327 melanoma antigen, 80 kDa11886 0.93171 1.04 down Mm.194045 AI314113 102037_at AI844269 expressed sequence AI31411311887 0.93180 1.02 up Mm.2252 1200008D14Rik 104337_f_at AW208938 RIKEN cDNA 1200008D14 gene11888 0.93182 1.04 up Mm.24006 1110013O05Rik 104594_at AA612146 RIKEN cDNA 1110013O05 gene11889 0.93196 1.03 down Mm.22564 H2-Eb1 94285_at X00958 histocompatibility 2, class II antigen E beta11890 0.93197 1.06 up Mm.23943 Vapa 161516_r_at AV157222 vesicle-associated membrane protein, associated protein A (33 kDa)11891 0.93211 1.03 down Mm.218611 Ramp2 99444_at AJ250490 receptor (calcitonin) activity modifying protein 211892 0.93214 1.05 down Mm.200521 4921540P06Rik 93221_at X56561 RIKEN cDNA 4921540P06 gene11893 0.93242 1.03 down Mm.130475 Mm.130475 95314_at AA030256 ESTs11894 0.93246 1.05 down Mm.5001 Dnmt3a 161170_r_at AV225794 DNA methyltransferase 3A11895 0.93249 1.03 up Mm.4735 Was 92760_at U42471 Wiskott-Aldrich syndrome homolog (human)11896 0.93257 1.03 down Mm.38792 Nsdhl 98630_at AW106745 NAD(P) dependent steroid dehydrogenase-like11897 0.93265 1.03 down Mm.24596 1700013L23Rik 104726_at AA670737 RIKEN cDNA 1700013L23 gene11898 0.93273 1.05 down Mm.153891 Ptp4a3 161905_r_at AV112492 protein tyrosine phosphatase 4a311899 0.93280 1.02 down Mm.34514 Arhgef3 160840_at AI853706 Rho guanine nucleotide exchange factor (GEF) 311900 0.93300 1.03 down Mm.27312 Pp6-pending 94990_at AI854725 placental protein 611901 0.93301 1.02 down Mm.3533 Txn2 98130_at U85089 thioredoxin 211902 0.93339 1.03 down Mm.24680 Dnpep 161143_r_at AV213208 aspartyl aminopeptidase11903 0.93348 1.02 down Mm.147946 Mybbp1a 98341_f_at AI506202 MYB binding protein (P160) 1a11904 0.93374 1.04 up Mm.26783 Mm.26783 161641_at AV067171 Mus musculus, clone MGC:6974 IMAGE:3154632, mRNA, complete cds11905 0.93397 1.03 down Mm.18109 Mm.18109 160622_at AW211793 Mus musculus, clone MGC:19050 IMAGE:4190027, mRNA, complete cds11906 0.93403 1.04 up Mm.28465 Lrp10 161625_r_at AV028190 low-density lipoprotein receptor-related protein 1011907 0.93408 1.03 up Mm.57056 Cmkbr1l1 101733_at U28405 chemokine (C-C) receptor 1,-like 111908 0.93409 1.04 up Mm.3500 Slc10a2 97150_at AB002693 solute carrier family 10, member 211909 0.93423 1.03 up Mm.45519 Slc27a3 92686_at AF072758 solute carrier family 27 (fatty acid transporter), member 311910 0.93450 1.04 down Mm.60590 Myo10 100923_at AJ249706 myosin X11911 0.93463 1.02 up Mm.140243 2010012D11Rik 162248_f_at AV334517 RIKEN cDNA 2010012D11 gene11912 0.93471 1.05 up Mm.4255 Pfkfb2 98329_at X98847 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 211913 0.93476 1.05 down Mm.203928 Stx3 100497_at D38375 syntaxin 311914 0.93490 1.05 up Mm.30271 Csh1 97940_at M35662 chorionic somatomammotropin hormone 111915 0.93502 1.02 up Mm.5129 Sts 98861_at AI430879 steroid sulfatase11916 0.93537 1.04 up Mm.24096 Thbd 104601_at X14432 thrombomodulin11917 0.93567 1.03 down Mm.4215 Cas1 161877_f_at AV083603 catalase 111918 0.93570 1.03 up Mm.24954 C77168 95964_at C77404 expressed sequence C7716811919 0.93582 1.02 down Mm.22179 1200009B18Rik 160151_i_at AW122811 RIKEN cDNA 1200009B18 gene11920 0.93612 1.05 down Mm.3320 Prpb-pending 100731_at M11900 proline-rich protein B, salivary11921 0.93627 1.04 down Mm.25033 Mm.25033 95983_at C79183 ESTs11922 0.93654 1.02 up Mm.22684 Slc35a1 104380_at Z71268 solute carrier family 35 (CMP-sialic acid transporter), member 111923 0.93664 1.03 down Mm.28734 Btrc 96224_at AF099932 beta-transducin repeat containing protein11924 0.93672 1.04 up Mm.196230 4432417F03Rik 103989_at AI314715 RIKEN cDNA 4432417F03 gene11925 0.93687 1.04 down Mm.30221 Mm.30221 92396_at AI840465 ESTs, Highly similar to INSULIN-INDUCED GROWTH RESPONSE PROTEI11926 0.93704 1.04 down Mm.62618 Mm.62618 161450_r_at AV291437 EST11927 0.93705 1.02 up Mm.167900 Clcnk1 103782_at C76513 chloride channel K111928 0.93718 1.04 up Mm.6452 Mm.6452 161076_at AI462312 Mus musculus, clone MGC:36997 IMAGE:4948448, mRNA, complete cds11929 0.93723 1.02 up Mm.2395 Mea1 94891_s_at M27938 male enhanced antigen 111930 0.93734 1.02 up Mm.28968 Ncbp2 94509_at AI851207 nuclear cap binding protein subunit 2, 20kDa11931 0.93771 1.04 up Mm.22025 3322402E17Rik 104123_at AW120727 RIKEN cDNA 3322402E17 gene11932 0.93779 1.02 up Mm.24703 AA408880 95458_s_at AW121960 expressed sequence AA40888011933 0.93785 1.02 down Mm.34556 Car14 98078_at AI157911 carbonic anhydrase 1411934 0.93803 1.01 down Mm.86595 Shc1 104350_at AI050321 src homology 2 domain-containing transforming protein C111935 0.93804 1.02 up Mm.5434 Mm.5434 93183_at AA726565 Mus musculus, clone IMAGE:3499034, mRNA, partial cds11936 0.93826 1.03 up Mm.10736 Casp8 102328_at AJ007749 caspase 811937 0.93848 1.01 down Mm.200980 4933429H19Rik 160136_r_at AI120170 RIKEN cDNA 4933429H19 gene11938 0.93848 1.04 down Mm.2420 Galt 104615_at M96265 galactose-1-phosphate uridyl transferase11939 0.93850 1.02 down Mm.2927 Zfp30 104437_at Z30174 zinc finger protein 3011940 0.93868 1.02 down Mm.57030 Pnmt 101719_at L12687 phenylethanolamine-N-methyltransferase11941 0.93875 1.03 down Mm.157864 Mm.157864 100776_at AI117463 ESTs, Weakly similar to I49636 DNA-binding protein - mouse [M.musculus]11942 0.93882 1.03 down Mm.218360 Mm.218360 96215_f_at AI153421 Mus musculus, clone IMAGE:3983821, mRNA, partial cds11943 0.93890 1.02 down Mm.24995 4921526G09Rik 160982_at AW213866 RIKEN cDNA 4921526G09 gene11944 0.93891 1.03 down Mm.5080 Sox17 92997_g_at D49473 SRY-box containing gene 1711945 0.93893 1.01 down Mm.19169 Txnl 160115_at AF052660 thioredoxin-like (32kD)11946 0.93902 1.03 up Mm.12925 Pde6d 160602_at AF039216 phosphodiesterase 6D, cGMP-specific, rod, delta11947 0.93911 1.03 down Mm.38051 Mm.38051 97706_at AA474655 ESTs11948 0.93914 1.02 up Mm.2668 Ptpn1 94929_at M97590 protein tyrosine phosphatase, non-receptor type 111949 0.93919 1.04 down Mm.196000 Col18a1 101880_at L22545 procollagen, type XVIII, alpha 111950 0.93929 1.02 down Mm.1591 Pten 160614_at U92437 phosphatase and tensin homolog11951 0.93930 1.03 down Mm.22329 Gcgr 103498_at L38613 glucagon receptor11952 0.93943 1.02 down Mm.4071 Lamr1 96016_at AW045665 laminin receptor 1 (67kD, ribosomal protein SA)11953 0.93959 1.02 up Mm.45225 2510005D08Rik 100073_at AW045965 RIKEN cDNA 2510005D08 gene11954 0.93963 1.04 up Mm.46791 Insr 102146_at J05149 insulin receptor11955 0.93979 1.06 up Mm.20413 Hao3 103649_at AI648067 hydroxyacid oxidase (glycolate oxidase) 311956 0.93980 1.04 up Mm.57191 Vav 99799_at X64361 vav oncogene11957 0.93998 1.02 up Mm.24671 2900026B15Rik 104740_at AW125318 RIKEN cDNA 2900026B15 gene11958 0.94007 1.04 up Mm.3227 Itih1 98014_at X70391 inter-alpha trypsin inhibitor, heavy chain 111959 0.94013 1.04 down Mm.195877 Sh3bp3 95792_at U59739 SH3-domain binding protein 311960 0.94026 1.02 down Mm.29911 3200001M24Rik 96301_at AI851912 RIKEN cDNA 3200001M24 gene11961 0.94051 1.02 up Mm.455 Tcf1 100082_at M57966 transcription factor 111962 0.94064 1.05 down Mm.5128 Htf9c 162149_i_at AV325777 HpaII tiny fragments locus 9c11963 0.94066 1.02 down Mm.4845 Tcfap2a 92922_at U17291 transcription factor AP-2, alpha11964 0.94070 1.03 down Mm.206799 D9Wsu18e 95430_f_at AI854154 DNA segment, Chr 9, Wayne State University 18, expressed11965 0.94092 1.03 up Mm.6780 Cer1 93452_at AF031896 cerberus 1 homolog (Xenopus laevis)11966 0.94097 1.02 up Mm.27202 Crygd 104171_f_at AJ224342 crystallin, gamma D11967 0.94100 1.03 down Mm.3517 Spi15 100738_at U96701 serine protease inhibitor 1511968 0.94103 1.03 down Mm.5062 Pctp 101173_at Z50024 phosphatidylcholine transfer protein11969 0.94108 1.04 down Mm.27094 2310008B08Rik 161195_i_at AV253092 RIKEN cDNA 2310008B08 gene11970 0.94122 1.03 down Mm.26696 1200013I08Rik 104049_at AW047134 RIKEN cDNA 1200013I08 genePage 133 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description11971 0.94123 1.02 up Mm.19143 Alas1 93500_at M63245 aminolevulinic acid synthase 111972 0.94171 1.04 up Mm.1398 Ptprn2 94708_at U57345 protein tyrosine phosphatase, receptor-type, N polypeptide 211973 0.94198 1.04 up Mm.25066 C80256 95996_at AU020743 expressed sequence C8025611974 0.94236 1.01 up Mm.22409 Clic4 94254_at AI845237 chloride intracellular channel 4 (mitochondrial)11975 0.94238 1.03 up Mm.46428 Sbp 98830_at X06246 spermine binding protein11976 0.94241 1.01 down Mm.29196 Cyc1 95072_at AW121892 cytochrome c-111977 0.94247 1.05 down Mm.1708 Cd22 102939_s_at L02844 CD22 antigen11978 0.94271 1.05 down Mm.20876 Lrp5 103806_at AF064984 low density lipoprotein receptor-related protein 511979 0.94306 1.01 down Mm.2992 Mbp 96310_at L07508 myelin basic protein11980 0.94340 1.02 down Mm.10586 2410003M04Rik 92584_at AI843556 RIKEN cDNA 2410003M04 gene11981 0.94348 1.04 up Mm.16479 2310076D10Rik 102925_at AA285446 RIKEN cDNA 2310076D10 gene11982 0.94358 1.05 up Mm.27086 2410012A13Rik 162352_r_at AV174743 RIKEN cDNA 2410012A13 gene11983 0.94359 1.04 up Mm.177311 Mm.177311 161351_r_at AV172782 EST11984 0.94397 1.01 down Mm.29211 Rabggtb 95077_at U12922 RAB geranylgeranyl transferase, b subunit11985 0.94423 1.01 up Mm.24 Hnrpab 94896_at D90151 heterogeneous nuclear ribonucleoprotein A/B11986 0.94443 1.04 down Mm.5522 D9Ertd26e 99359_at C76688 DNA segment, Chr 9, ERATO Doi 26, expressed11987 0.94489 1.02 up Mm.196027 Cpr2-pending 100442_at AA656541 cell cycle progression 2 protein11988 0.94509 1.02 down Mm.6584 Hpd 100620_at D29987 4-hydroxyphenylpyruvic acid dioxygenase11989 0.94514 1.04 up Mm.34708 2610019N19Rik 98097_r_at AI840219 RIKEN cDNA 2610019N19 gene11990 0.94516 1.02 down Mm.21065 5730449L18Rik 93742_at AW045476 RIKEN cDNA 5730449L18 gene11991 0.94554 1.02 up Mm.3921 Casp2 161263_f_at AV313584 caspase 211992 0.94570 1.01 up 93710_at M3775911993 0.94584 1.03 down Mm.1402 Vegfc 94712_at U73620 vascular endothelial growth factor C11994 0.94605 1.02 up Mm.218624 Sh3yl1 103813_at D85926 Sh3 domain YSC-like 111995 0.94635 1.01 down Mm.173831 1810010K08Rik 94470_i_at AW045974 RIKEN cDNA 1810010K08 gene11996 0.94636 1.04 down Mm.27454 Prps1 104039_at AI226153 phosphoribosyl pyrophosphate synthetase 111997 0.94636 1.01 down Mm.29648 Degs 95688_at Y08460 degenerative spermatocyte homolog (Drosophila)11998 0.94648 1.03 down Mm.27966 Mm.27966 161002_at AI155127 ESTs, Weakly similar to [Human chromosome 3p21.1 gene sequence, comp11999 0.94655 1.04 up Mm.41971 Phxr2 101699_at X12808 per-hexamer repeat gene 212000 0.94661 1.02 down Mm.905 Rsu1 101584_at X63039 Ras suppressor protein 112001 0.94689 1.01 down Mm.3363 Psap 97114_at U57999 prosaposin12002 0.94722 1.05 down Mm.6194 Ifna8 101619_at D00460 interferon alpha family, gene 812003 0.94723 1.01 down Mm.28571 Psmd11 160305_at AW121693 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1112004 0.94726 1.03 down Mm.154796 0710005A05Rik 103235_at AI848386 RIKEN cDNA 0710005A05 gene12005 0.94740 1.02 up Mm.24143 Bbp 104608_at AI854293 beta-amyloid binding protein precursor12006 0.94748 1.01 up Mm.21158 Frap1 104708_at AI463490 FK506 binding protein 12-rapamycin associated protein 112007 0.94752 1.03 down Mm.15694 Hira 103009_at X92590 histone cell cycle regulation defective homolog A (S. cerevisiae)12008 0.94789 1.02 up Mm.1433 Npy2r 162037_f_at AV372577 neuropeptide Y receptor Y212009 0.94794 1.03 down Mm.22514 0610008F14Rik 161047_at AV150561 RIKEN cDNA 0610008F14 gene12010 0.94817 1.03 up Mm.4012 Fgf8 97742_s_at D12483 fibroblast growth factor 812011 0.94824 1.05 up Mm.15479 H2-Ke6 102992_at U34072 H2-K region expressed gene 612012 0.94871 1.02 down Mm.26463 0610025K21Rik 96069_at AI840094 RIKEN cDNA 0610025K21 gene12013 0.94902 1.03 up Mm.12481 Cetn3 92789_r_at Y12474 centrin 312014 0.94902 1.01 down Mm.917 Inpp1 161407_i_at AV312395 inositol polyphosphate-1-phosphatase12015 0.94919 1.03 up Mm.5547 C76907 161973_r_at AV228768 expressed sequence C7690712016 0.94919 1.04 up Mm.200410 Klk9 162305_f_at AV045905 kallikrein 912017 0.94922 1.01 down Mm.4143 Gcdp 160468_at D78188 granule cell differentiation protein12018 0.94970 1.02 up Mm.200919 AI450287 94390_at AI646981 expressed sequence AI45028712019 0.94999 1.03 up Mm.12894 Kcnk4 94185_at AF056492 potassium channel, subfamily K, member 412020 0.95009 1.04 up Mm.21300 Igfbp1 103897_r_at X81579 insulin-like growth factor binding protein 112021 0.95059 1.01 down Mm.39288 Cd36l2 101389_at AB008553 CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 212022 0.95073 1.01 down Mm.8884 Nfkbia 101554_at U57524 nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha12023 0.95082 1.02 down Mm.2539 Mth1 94372_at D49956 mutT (E. coli) human homolog (8-oxo-dGTPase)12024 0.95086 1.02 down 95094_g_at AI03533412025 0.95093 1.01 down Mm.3957 Mm.3957 97737_f_at AW121931 ESTs, Weakly similar to T17255 hypothetical protein DKFZp586O1822.1 [H.12026 0.95097 1.02 down Mm.87062 Mrps25 104234_at AW125120 mitochondrial ribosomal protein S2512027 0.95127 1.02 down Mm.28932 AA682085 96741_at AW124129 expressed sequence AA68208512028 0.95129 1.03 down Mm.6354 Pigq 162027_f_at AV366200 phosphatidylinositol glycan, class Q12029 0.95140 1.03 up Mm.142 Lck 102809_s_at M12056 lymphocyte protein tyrosine kinase12030 0.95159 1.02 up Mm.29771 Atp6a1 95745_g_at U13837 ATPase, H+ transporting, lysosomal (vacuolar proton pump), alpha 70 kDa, i12031 0.95178 1.02 down Mm.57058 Angrp 101735_f_at U22519 angiogenin related protein12032 0.95179 1.01 down Mm.3974 Usp4 99064_at AF026469 ubiquitin specific protease 4 (proto-oncogene)12033 0.95183 1.02 down Mm.24791 Zw10 104757_at AF003951 ZW10 homolog (Drosophila), centromere/kinetochore protein12034 0.95210 1.03 up Mm.2874 Cbg 161326_f_at AV104178 corticosteroid binding globulin12035 0.95213 1.02 up Mm.6209 Capn9 99833_at U89513 calpain 9 (nCL-4)12036 0.95224 1.02 down Mm.566 Orc5 100894_at AJ007360 origin recognition complex, subunit 5 homolog (S. cerevisiae)12037 0.95252 1.02 up Mm.30717 Synj2 97962_at AF041859 synaptojanin 212038 0.95267 1.02 up Mm.12829 Casq1 102426_at U93291 calsequestrin 112039 0.95274 1.04 up Mm.29633 1810008O21Rik 161298_i_at AV049156 RIKEN cDNA 1810008O21 gene12040 0.95287 1.02 up Mm.5068 Sh3d4 98848_at U58889 SH3 domain protein 412041 0.95329 1.01 down Mm.3527 Ccng2 98478_at U95826 cyclin G212042 0.95343 1.03 up Mm.35830 Hbb-y 97180_f_at V00726 hemoglobin Y, beta-like embryonic chain12043 0.95345 1.01 down Mm.3990 Skd3 99111_at U09874 suppressor of K+ transport defect 312044 0.95359 1.02 up Mm.196040 Pole3 100408_at AA839465 DNA polymerase epsilon, subunit 312045 0.95363 1.02 down Mm.204698 Mm.204698 162455_f_at AV041013 Mus musculus, clone MGC:37879 IMAGE:5101205, mRNA, complete cds12046 0.95409 1.02 down Mm.25575 Matr3 96011_at AB009275 matrin 312047 0.95420 1.02 up Mm.35474 Stmn4 98486_at AF105222 stathmin-like 412048 0.95439 1.02 down Mm.295 Mm.295 96565_at AI447589 ESTs12049 0.95451 1.03 down Mm.157783 AI893585 99885_at M12376 expressed sequence AI89358512050 0.95467 1.02 up Mm.41963 Xtrp3 92454_at AF075261 X transporter protein 312051 0.95471 1.02 up Mm.151329 Mm.151329 93070_at AI847564 Mus musculus Ran binding protein 5 mRNA, partial cds12052 0.95491 1.02 up Mm.18460 Mm.18460 103359_at AI854144 Mus musculus, Similar to hypothetical protein FLJ13984, clone MGC:7995 IM12053 0.95491 1.01 up Mm.22029 Mm.22029 94059_at AI852524 Mus musculus, Similar to nuclear receptor binding protein, clone MGC:696112054 0.95518 1.02 up Mm.622 Supt4h 100585_at U96809 suppressor of Ty 4 homolog (S. cerevisiae)12055 0.95526 1.03 up Mm.57238 Fgf11 102574_at U66203 fibroblast growth factor 1112056 0.95552 1.05 up Mm.6590 Sult-x2 99854_at AF026075 sulfotransferase-related protein SULT-X212057 0.95591 1.01 up Mm.781 Gt(ROSA)26asSor 101444_at U83176 gene trap ROSA 26 antisense, Philippe Soriano12058 0.95609 1.03 down Mm.21082 Mm.21082 160660_r_at AI157424 Mus musculus, Similar to hypothetical protein MGC2555, clone MGC:2901812059 0.95633 1.02 down Mm.87854 Atp7b 100335_at U38477 ATPase, Cu++ transporting, beta polypeptide12060 0.95646 1.04 up Mm.34570 Rpo1-3 161852_i_at AV054908 RNA polymerase 1-3 (16 kDa subunit)Page 134 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description12061 0.95651 1.03 down Mm.29981 Bhmt2 97418_at AA986608 betaine-homocysteine methyltransferase 212062 0.95652 1.01 down Mm.35016 H2-T23 98472_at Y00629 histocompatibility 2, T region locus 2312063 0.95662 1.03 up Mm.202370 AI842128 161031_at AI842128 expressed sequence AI84212812064 0.95689 1.02 up Mm.24385 Mm.24385 103736_at AI837786 ESTs12065 0.95708 1.03 up Mm.86646 Maff 100302_at AB009694 v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)12066 0.95725 1.01 down Mm.24632 C76800 103762_at AI853340 expressed sequence C7680012067 0.95734 1.04 down Mm.57199 Ret 101828_at X67812 ret proto-oncogene12068 0.95761 1.03 down Mm.15530 Lhx8 94754_at D49658 LIM homeobox protein 812069 0.95764 1.02 up Mm.13352 C81521 94695_at C81411 expressed sequence C8152112070 0.95764 1.01 down Mm.198391 AW045710 92430_at AW045710 expressed sequence AW04571012071 0.95768 1.02 up Mm.219665 Mm.219665 97992_at AI848304 Mus musculus, Similar to KIAA1089 protein, clone MGC:30464 IMAGE:399212072 0.95797 1.01 up Mm.26609 D8Ertd69e 94923_f_at AA543502 DNA segment, Chr 8, ERATO Doi 69, expressed12073 0.95807 1.01 up Mm.7271 Nxf1 101079_at AF093140 nuclear RNA export factor 1 homolog (S. cerevisiae)12074 0.95807 1.03 down Mm.26544 Hoxd9 99426_at X62669 homeo box D912075 0.95815 1.01 down Mm.142188 Cox7b 101580_at AI851220 cytochrome c oxidase subunit VIIb12076 0.95816 1.02 down Mm.32321 Vamp1 93652_i_at U61751 vesicle-associated membrane protein 112077 0.95839 1.02 down Mm.41682 Mrps5 160470_at AI840436 mitochondrial ribosomal protein S512078 0.95843 1.02 up Mm.1956 Mm.1956 103575_at M55424 Mouse brain neurofilament-L mRNA, complete cds12079 0.95864 1.02 up Mm.25001 C78811 95975_at C79030 expressed sequence C7881112080 0.95868 1.02 up Mm.39292 Dnm2 92351_at L31398 dynamin 212081 0.95874 1.01 down Mm.18571 Zfp36l1 93324_at M58566 zinc finger protein 36, C3H type-like 112082 0.95889 1.04 up Mm.3446 Dck 98072_r_at X77731 deoxycytidine kinase12083 0.95907 1.02 up Mm.970 Ckmt1 160565_at Z13969 creatine kinase, mitochondrial 1, ubiquitous12084 0.95915 1.02 down Mm.31726 AI838661 104473_at AA693180 expressed sequence AI83866112085 0.95932 1.01 up Mm.200479 2610319K07Rik 104744_at AW046775 RIKEN cDNA 2610319K07 gene12086 0.95935 1.01 down Mm.21698 Mm.21698 104076_at AW122061 Mus musculus, clone MGC:11750 IMAGE:3152735, mRNA, complete cds12087 0.95948 1.02 down Mm.13145 Umps 101455_at M29395 uridine monophosphate synthetase12088 0.95959 1.02 down Mm.3465 Epb4.1l4a 92231_at D28818 erythrocyte protein band 4.1-like 4a12089 0.95977 1.03 down Mm.216321 Ate1 103475_s_at AF079096 arginine-tRNA-protein transferase 112090 0.95987 1.01 up Mm.29937 2310044H10Rik 96320_at AW121862 RIKEN cDNA 2310044H10 gene12091 0.95993 1.01 up Mm.4449 Endog 162033_f_at AV258758 endonuclease G12092 0.95994 1.03 up Mm.153837 Kcnj1 103973_at AA986344 potassium inwardly-rectifying channel, subfamily J, member 112093 0.95994 1.03 down Mm.5017 Col11a1 100481_at D38162 procollagen, type XI, alpha 112094 0.96013 1.02 down Mm.20847 Snx5 93598_at AI840437 sorting nexin 512095 0.96033 1.01 down Mm.17307 1500012C14Rik 93267_at AA688834 RIKEN cDNA 1500012C14 gene12096 0.96116 1.01 up Mm.29105 Gtf3a 94558_g_at AI850893 general transcription factor III A12097 0.96119 1.01 up Mm.30236 Acinus-pending 97441_at AI839299 apoptotic chromatin condensation inducer in the nucleus12098 0.96127 1.01 up Mm.22294 1110038F14Rik 94233_at AW048642 RIKEN cDNA 1110038F14 gene12099 0.96127 1.01 up Mm.28899 1110059P08Rik 94488_at AI847041 RIKEN cDNA 1110059P08 gene12100 0.96154 1.01 down Mm.24169 Cebpa-rs1 94466_f_at U19891 CCAAT/enhancer binding protein alpha (C/EBP), related sequence 112101 0.96155 1.02 down Mm.5129 Sts 98860_at U37545 steroid sulfatase12102 0.96186 1.02 up Mm.4944 Il3ra 92955_at X64534 interleukin 3 receptor, alpha chain12103 0.96200 1.04 down Mm.31117 C76601 96600_at C76597 expressed sequence C7660112104 0.96210 1.02 up Mm.5250 R74862 161058_f_at AW121924 expressed sequence R7486212105 0.96217 1.02 down Mm.200506 R75394 160173_at AI852838 expressed sequence R7539412106 0.96235 1.01 down Mm.15985 Gng3lg 93080_at AF069954 G protein gamma 3 linked gene12107 0.96239 1.02 up Mm.104747 Igk-V28 93227_f_at Z70661 immunoglobulin kappa chain variable 28 (V28)12108 0.96247 1.03 down 93514_at X1297212109 0.96249 1.02 up Mm.157711 Elac2 97166_at W49316 elaC homolog 2 (E. coli)12110 0.96263 1.02 up Mm.19963 Mm.19963 95303_at AA144469 ESTs, Weakly similar to putative haemopoietic membrane protein [M.muscul12111 0.96264 1.01 up Mm.22417 Cse1l 104317_at AW123099 chromosome segregation 1-like (S. cerevisiae)12112 0.96273 1.01 up Mm.28103 1810009A15Rik 161444_f_at AV352777 RIKEN cDNA 1810009A15 gene12113 0.96277 1.02 down Mm.27454 Prps1 161897_f_at AV107396 phosphoribosyl pyrophosphate synthetase 112114 0.96284 1.02 up Mm.86425 Chrnb1 93705_at M14537 cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)12115 0.96304 1.01 up Mm.27114 0610043B10Rik 96615_at AI840137 RIKEN cDNA 0610043B10 gene12116 0.96334 1.01 down Mm.21645 Anapc11 93967_at AI850979 anaphase promoting complex subunit 11 homolog (yeast)12117 0.96390 1.01 down Mm.3636 Dbt 98966_at L42996 dihydrolipoamide branched chain transacylase E212118 0.96391 1.02 up Mm.3776 Myhca 101071_at M76599 myosin heavy chain, cardiac muscle, adult12119 0.96392 1.02 up Mm.258 Atp5g1 96032_at L19737 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subuni12120 0.96406 1.01 down Mm.177194 Akt2 160558_at U22445 thymoma viral proto-oncogene 212121 0.96420 1.02 down Mm.12954 Vti1-pending 102635_at AF035823 vesicle transport through interaction with t-SNAREs 1 homolog12122 0.96421 1.01 up Mm.142827 DXImx46e 96814_r_at AI852973 DNA segment, Chr X, Immunex 46, expressed12123 0.96435 1.04 down Mm.5047 Zic2 98843_at D70848 zinc finger protein of the cerebellum 212124 0.96436 1.03 down Mm.3135 Igfals 162450_f_at AV027236 insulin-like growth factor binding protein, acid labile subunit12125 0.96450 1.02 down Mm.20853 Ltb4r1 103266_at AF044030 leukotriene B4 receptor 112126 0.96498 1.02 up Mm.917 Inpp1 93942_at U27295 inositol polyphosphate-1-phosphatase12127 0.96507 1.02 up Mm.667 Gstm5 100629_at U24428 glutathione S-transferase, mu 512128 0.96554 1.03 down Mm.2185 Bub1 104097_at AF002823 budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)12129 0.96558 1.03 up Mm.16910 C81272 94786_at C81191 expressed sequence C8127212130 0.96579 1.02 up Mm.24679 Mm.24679 104742_at AA919832 ESTs, Weakly similar to LEUKOTRIENE C4 SYNTHASE [M.musculus]12131 0.96605 1.03 down Mm.34869 Ndufa1 98118_at Y07708 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 112132 0.96613 1.01 down Mm.35009 Gpr27 97151_at AF027955 G protein-coupled receptor 2712133 0.96620 1.01 down Mm.37199 Gstm3 97682_r_at J03953 glutathione S-transferase, mu 312134 0.96633 1.02 down Mm.24276 C1r 95414_i_at AI132585 complement component 1, r subcomponent12135 0.96638 1.02 up Mm.219670 Mm.219670 103926_at AV380793 Mus musculus, Similar to eukaryotic translation initiation factor 4 gamma, 1,12136 0.96651 1.02 down Mm.35796 Evi5 98503_at U53586 ecotropic viral integration site 512137 0.96654 1.02 up Mm.181969 Timp2 93507_at X62622 tissue inhibitor of metalloproteinase 212138 0.96666 1.02 up Mm.32595 AI847979 100386_at AF056973 expressed sequence AI84797912139 0.96675 1.01 down Mm.196085 Igh-4 98765_f_at U23095 immunoglobulin heavy chain 4 (serum IgG1)12140 0.96686 1.01 up Mm.7719 Bmi1 101475_at M64068 B lymphoma Mo-MLV insertion region 112141 0.96686 1.01 up Mm.3217 Ass1 97521_at M31690 argininosuccinate synthetase 112142 0.96697 1.01 up Mm.30150 1010001M12Rik 162496_r_at AV153195 RIKEN cDNA 1010001M12 gene12143 0.96700 1.02 down Mm.28553 5730589K01Rik 96196_i_at AI851708 RIKEN cDNA 5730589K01 gene12144 0.96703 1.02 down Mm.6825 2310005P05Rik 160916_at AI838150 RIKEN cDNA 2310005P05 gene12145 0.96710 1.01 down Mm.27308 AI788669 104179_at AI788669 expressed sequence AI78866912146 0.96744 1.02 up Mm.12396 Znfn1a1 102294_at AI325349 zinc finger protein, subfamily 1A, 1 (Ikaros)12147 0.96749 1.02 down Mm.4450 Esp 92663_at AW046257 embryonic stem cell phosphatase12148 0.96759 1.02 up Mm.5090 Tdgf1 93002_r_at M87321 teratocarcinoma-derived growth factor12149 0.96781 1.03 down Mm.4758 Foxd3 92889_r_at AF067421 forkhead box D312150 0.96785 1.01 down Mm.3434 Surf5 98430_at X85169 surfeit gene 5Page 135 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description12151 0.96795 1.02 down Mm.29971 Snx2 96332_at AW259199 sorting nexin 212152 0.96815 1.02 up Mm.1948 Tctex1 93516_at M25825 t-complex <strong>test</strong>is expressed 112153 0.96834 1.01 up Mm.34302 Lypla2 98429_at AB009653 lysophospholipase 212154 0.96840 1.02 down Mm.9015 Gas11 92725_at AI226341 growth arrest specific 1112155 0.96863 1.01 up Mm.30539 2310020D06Rik 97469_at AI645662 RIKEN cDNA 2310020D06 gene12156 0.96863 1.01 down Mm.28378 Mrps11 97884_at AI844175 mitochondrial ribosomal protein S1112157 0.96866 1.01 up Mm.26532 8430434E15Rik 103998_at AW122699 RIKEN cDNA 8430434E15 gene12158 0.96868 1.02 down Mm.14435 Hsd3b6 102729_f_at AF031170 hydroxysteroid dehydrogenase-6, delta-3-beta12159 0.96874 1.01 up Mm.27653 Zfp106 101456_at AF060245 zinc finger protein 10612160 0.96898 1.01 up Mm.153797 Bcl2 98870_at L31532 B-cell leukemia/lymphoma 212161 0.96905 1.01 down Mm.23963 Plcd 104580_at U85711 phospholipase C, delta12162 0.96909 1.02 up Mm.2817 Ppfibp2 162129_f_at AV378129 protein tyrosine phosphatase, receptor-type, F interacting protein, binding pro12163 0.96909 1.02 down Mm.30020 C77652 161489_r_at AV081291 expressed sequence C7765212164 0.96933 1.02 up Mm.200153 AI450389 160928_at AI662265 expressed sequence AI45038912165 0.96934 1.01 up Mm.28965 0710007A14Rik 96750_at AW122179 RIKEN cDNA 0710007A14 gene12166 0.96935 1.01 up Mm.182574 2610034N03Rik 97247_at AW124778 RIKEN cDNA 2610034N03 gene12167 0.96937 1.00 up Mm.28286 4931406I20Rik 160282_at AI847490 RIKEN cDNA 4931406I20 gene12168 0.96953 1.01 down Mm.7373 Per1 93619_at AF022992 period homolog 1 (Drosophila)12169 0.96993 1.01 down Mm.28200 D11Ertd730e 161428_at AV302712 DNA segment, Chr 11, ERATO Doi 730, expressed12170 0.96998 1.02 up Mm.42163 Casp12 92488_at Y13090 caspase 1212171 0.97016 1.02 up Mm.100156 Mm.100156 94089_at C81018 ESTs12172 0.97021 1.03 down Mm.2655 qk 161296_r_at AV347370 quaking12173 0.97063 1.02 down Mm.20285 Krt2-19 162375_i_at AV243067 keratin complex 2, basic, gene 1912174 0.97073 1.01 up Mm.10665 Mm.10665 102315_at AW124570 Mus musculus, clone IMAGE:3498496, mRNA, partial cds12175 0.97120 1.01 down Mm.27348 Rala 94998_at AI838452 v-ral simian leukemia viral oncogene homolog A (ras related)12176 0.97129 1.02 up 101279_f_at AF09387012177 0.97131 1.02 up Mm.2213 Ercc5 161777_f_at AV345471 excision repair cross-complementing rodent repair deficiency,complementati12178 0.97133 1.02 down Mm.3176 Prkar2a 97096_at J02935 protein kinase, cAMP dependent regulatory, type II alpha12179 0.97199 1.01 up Mm.3116 AI561871 97977_at AA645293 expressed sequence AI56187112180 0.97217 1.02 down Mm.1804 Mm.1804 94798_at AI450248 ESTs12181 0.97222 1.02 down Mm.140785 Scd1 94058_r_at AW047819 stearoyl-Coenzyme A desaturase 112182 0.97232 1.01 down Mm.14125 Nat1 94723_at U37119 N-acetyltransferase 1 (arylamine N-acetyltransferase)12183 0.97256 1.02 up Mm.4720 Gpcr12 98785_at AW122201 G-protein coupled receptor 1212184 0.97258 1.01 up Mm.512 Wbp5 100523_r_at U92454 WW domain binding protein 512185 0.97261 1.02 down Mm.6125 Mm.6125 101613_at AA672647 ESTs, Weakly similar to MNN4_YEAST MNN4 PROTEIN [S.cerevisiae]12186 0.97264 1.01 up Mm.41984 E130201N16Rik 92457_at AJ132433 RIKEN cDNA E130201N16 gene12187 0.97265 1.01 up Mm.206250 AI504298 98036_at AA870525 expressed sequence AI50429812188 0.97270 1.02 up Mm.3411 Orc2 161651_f_at AV094683 origin recognition complex, subunit 2 homolog (S. cerevisiae)12189 0.97282 1.01 down Mm.29878 1300006C06Rik 97401_at AW124244 RIKEN cDNA 1300006C06 gene12190 0.97301 1.01 up Mm.28300 1810006O10Rik 97857_at AW047762 RIKEN cDNA 1810006O10 gene12191 0.97310 1.02 up Mm.46716 0610041G12Rik 100117_at AW122073 RIKEN cDNA 0610041G12 gene12192 0.97331 1.01 up Mm.2252 1200008D14Rik 162194_r_at AV371942 RIKEN cDNA 1200008D14 gene12193 0.97347 1.01 down Mm.28362 AI326478 92470_f_at AF065324 expressed sequence AI32647812194 0.97364 1.01 up Mm.25860 Map4k2 103985_at U50595 mitogen activated protein kinase kinase kinase kinase 212195 0.97365 1.00 up Mm.29895 0610038F01Rik 96289_at AW061287 RIKEN cDNA 0610038F01 gene12196 0.97387 1.01 down Mm.145208 Mm.145208 103688_at AW122834 ESTs, Weakly similar to 2003319A ankyrin B:ISOTYPE=440kD [H.sapiens]12197 0.97387 1.01 down Mm.16753 Chek1 103064_at AF016583 checkpoint kinase 1 homolog (S. pombe)12198 0.97431 1.01 up Mm.8321 Cit 93686_s_at AF086824 citron12199 0.97433 1.00 up Mm.24601 1810034K20Rik 95447_at AA683761 RIKEN cDNA 1810034K20 gene12200 0.97444 1.02 down Mm.15050 Dazl 160357_at AA414507 deleted in azoospermia-like12201 0.97456 1.01 down Mm.493 Ctcf 100148_at U51037 CCCTC-binding factor12202 0.97479 1.01 up Mm.5148 Has2 98865_at U52524 hyaluronan synthase 212203 0.97492 1.01 down Mm.29274 AI415285 161380_f_at AV245978 expressed sequence AI41528512204 0.97504 1.03 up Mm.4245 AU015084 98327_at AA517848 expressed sequence AU01508412205 0.97567 1.01 up Mm.197663 2610001A11Rik 104576_at AW212397 RIKEN cDNA 2610001A11 gene12206 0.97590 1.01 down Mm.43671 5730518J08Rik 99647_at AI845578 RIKEN cDNA 5730518J08 gene12207 0.97592 1.01 down Mm.27831 1810003N24Rik 97237_at AI837771 RIKEN cDNA 1810003N24 gene12208 0.97611 1.01 down Mm.117043 Ttf1 96435_at X83974 transcription termination factor 112209 0.97617 1.02 down Mm.219621 Glycam1 98063_at M93428 glycosylation dependent cell adhesion molecule 112210 0.97634 1.00 down Mm.41800 Gtpbp3-pending 99180_at AI851237 GTP binding protein 312211 0.97641 1.02 down Mm.35670 Abcc9 103273_s_at AF037312 ATP-binding cassette, sub-family C (CFTR/MRP), member 912212 0.97656 1.01 down Mm.88851 Smok2 97007_at AJ245454 sperm motility kinase 212213 0.97659 1.01 up Mm.29142 1500016M21Rik 96793_at AI607813 RIKEN cDNA 1500016M21 gene12214 0.97666 1.02 down Mm.4119 Sva 97757_at L44117 seminal vesicle antigen12215 0.97667 1.02 up Mm.88839 Inac-pending 96997_at Y19035 amiloride-sensitive sodium channel12216 0.97684 1.02 down Mm.21870 Mm.21870 103472_at AI605402 ESTs12217 0.97719 1.02 down Mm.21579 H2bfs 162169_r_at AV047268 H2B histone family, member S12218 0.97729 1.01 up Mm.6922 9130211I03Rik 93465_at AA711915 RIKEN cDNA 9130211I03 gene12219 0.97745 1.02 down Mm.38444 Cdc25b 99012_at AI849132 cell division cycle 25 homolog B (S. cerevisiae)12220 0.97756 1.02 up Mm.89937 Mab21l2 95379_at AA245183 mab-21-like 2 (C. elegans)12221 0.97765 1.02 up Mm.42141 Scn10a 98302_at L42342 sodium channel, voltage-gated, type X, alpha polypeptide12222 0.97774 1.01 down Mm.30201 Arhg 97927_at AB025943 ras homolog G (RhoG)12223 0.97775 1.01 down Mm.1654 Mm.1654 161737_at AV312560 ESTs, Moderately similar to AF151806 1 CGI-48 protein [H.sapiens]12224 0.97779 1.01 up Mm.21515 Zfr 104050_at AI846060 zinc finger RNA binding protein12225 0.97788 1.01 down Mm.46053 Fgfbp1 103995_at AF065441 fibroblast growth factor binding protein 112226 0.97824 1.01 up Mm.1061 Fdx1 92587_at L29123 ferredoxin 112227 0.97830 1.02 down Mm.57033 Mm.57033 101826_at X58216 M.musculus immunoglobulin kappa chain variable region12228 0.97833 1.01 up Mm.108854 Mm.108854 92377_at AI844960 ESTs12229 0.97839 1.02 up Mm.22564 H2-Eb1 97048_at X05315 histocompatibility 2, class II antigen E beta12230 0.97840 1.01 down Mm.409 Mm.409 92402_at M73818 Mouse intracisternal A-particle-related retroviral elements and envelope pseu12231 0.97840 1.01 down Mm.6666 Zfp316 93442_at AF031955 zinc finger protein 31612232 0.97856 1.00 up Mm.3576 Cct3 161238_f_at AV268209 chaperonin subunit 3 (gamma)12233 0.97860 1.01 up Mm.74132 Mm.74132 161769_r_at AV342517 EST12234 0.97861 1.01 up Mm.34946 C80197 97145_at C80197 expressed sequence C8019712235 0.97864 1.01 down Mm.15050 Dazl 94750_at U46694 deleted in azoospermia-like12236 0.97881 1.02 down Mm.40247 Cdh10 94641_at U69137 cadherin 1012237 0.97890 1.02 up Mm.4951 Kcnj2 98823_at AF021136 potassium inwardly-rectifying channel, subfamily J, member 212238 0.97896 1.01 down Mm.11946 AU041093 102374_at AI847661 expressed sequence AU04109312239 0.97916 1.01 down Mm.2389 Mll 104568_at L17069 myeloid/lymphoid or mixed-lineage leukemia12240 0.97937 1.01 down Mm.218657 Cla3 97345_at AI849333 cerebellar ataxia 3Page 136 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description12241 0.97940 1.01 up Mm.138725 2510001K09Rik 94511_at AI850546 RIKEN cDNA 2510001K09 gene12242 0.97945 1.01 down Mm.8688 0610011B04Rik 162280_f_at AV371656 RIKEN cDNA 0610011B04 gene12243 0.97952 1.00 up Mm.29947 Stk11 160372_at AB026255 serine/threonine kinase 1112244 0.97952 1.01 up Mm.189102 2810047L02Rik 104423_at AW212532 RIKEN cDNA 2810047L02 gene12245 0.97955 1.01 down Mm.8053 Htr7 100282_at Z23107 5-hydroxytryptamine (serotonin) receptor 712246 0.97955 1.01 up Mm.2688 Meg1 160219_r_at X64455 meiosis expressed gene 112247 0.97958 1.00 down Mm.2418 Zfp144 96961_at AI503821 zinc finger protein 14412248 0.97959 1.01 down Mm.35597 2410091M23Rik 92258_at AA793993 RIKEN cDNA 2410091M23 gene12249 0.97980 1.01 down Mm.28877 Mm.28877 94481_at AI851321 Mus musculus uridindiphosphoglucosepyrophosphorylase 2 (Ugp2) mRNA, c12250 0.97983 1.02 up Mm.3993 Ntrk2 99069_at M33385 neurotrophic tyrosine kinase, receptor, type 212251 0.98004 1.01 up Mm.22149 Sdha 94080_at AI835718 succinate dehydrogenase complex, subunit A, flavoprotein (Fp)12252 0.98009 1.01 up Mm.12716 6230416A05Rik 103361_at AI853856 RIKEN cDNA 6230416A05 gene12253 0.98011 1.00 up Mm.21482 Clns1a 93812_at U53455 chloride channel, nucleotide-sensitive, 1A12254 0.98056 1.01 up Mm.12436 2010300K22Rik 103888_at AA636171 RIKEN cDNA 2010300K22 gene12255 0.98065 1.01 down Mm.5612 C85189 100557_g_at AW121930 expressed sequence C8518912256 0.98085 1.01 down Mm.24745 1110001I24Rik 95462_at AW060951 RIKEN cDNA 1110001I24 gene12257 0.98098 1.01 up Mm.57029 Cyp7a1 99404_at L23754 cytochrome P450, 7a112258 0.98106 1.01 up Mm.3960 Irf3 99103_at AF036341 interferon regulatory factor 312259 0.98109 1.01 down Mm.7241 Slc2a8 101397_at AA870756 solute carrier family 2, (facilitated glucose transporter), member 812260 0.98118 1.01 up Mm.42949 1110012O05Rik 99609_at AI835826 RIKEN cDNA 1110012O05 gene12261 0.98125 1.00 up Mm.29208 9330160G10Rik 160800_at AA981257 RIKEN cDNA 9330160G10 gene12262 0.98129 1.01 down Mm.3774 2610005H11Rik 160445_at AI844714 RIKEN cDNA 2610005H11 gene12263 0.98135 1.01 up Mm.21396 Mm.21396 93794_at AI846393 Mus musculus, Similar to APP-binding protein 1, clone MGC:29435 IMAGE:312264 0.98138 1.01 up Mm.42051 Otp 102074_at Y10413 orthopedia homolog, (Drosophila)12265 0.98154 1.01 up Mm.14910 Cspg6 102853_at Y15128 chondroitin sulfate proteoglycan 612266 0.98160 1.01 up Mm.195050 Elk4 98732_at Z36885 ELK4, member of ETS oncogene family12267 0.98163 1.00 up Mm.57192 Cyp21a1 98456_at AF049850 cytochrome P450, 21, steroid 21 hydroxylase12268 0.98173 1.01 down Mm.8846 Fgf9 100346_at U33535 fibroblast growth factor 912269 0.98178 1.01 down Mm.20466 Il18rap 95333_at AF077347 interleukin 18 receptor accessory protein12270 0.98201 1.01 down Mm.87835 V2r12 101351_at AF022251 vomeronasal 2, receptor, 1212271 0.98203 1.00 down Mm.28285 2700023B17Rik 160281_at AI840773 RIKEN cDNA 2700023B17 gene12272 0.98207 1.00 down Mm.2246 Psmb7 94263_f_at D85570 proteasome (prosome, macropain) subunit, beta type 712273 0.98208 1.01 down Mm.5938 Myh9 102108_f_at AI505453 myosin heavy chain IX12274 0.98235 1.00 up Mm.174478 2610028L19Rik 97315_at AW121730 RIKEN cDNA 2610028L19 gene12275 0.98244 1.02 down Mm.28324 9130014I08Rik 162485_at AV121743 RIKEN cDNA 9130014I08 gene12276 0.98293 1.01 up Mm.30424 Ptger3 96589_at D17406 prostaglandin E receptor 3 (subtype EP3)12277 0.98297 1.01 up Mm.4482 Col1a2 161156_r_at AV230631 procollagen, type I, alpha 212278 0.98307 1.01 down Mm.7103 Pbx2 94442_s_at AF030001 pre B-cell leukemia transcription factor 212279 0.98316 1.01 up Mm.119 Nr4a1 102371_at X16995 nuclear receptor subfamily 4, group A, member 112280 0.98319 1.01 up Mm.96 Itgae 161730_f_at AV268095 integrin, alpha E, epithelial-associated12281 0.98340 1.01 down Mm.22438 Ssbp2 100768_at C77307 single-stranded DNA binding protein 212282 0.98344 1.01 down Mm.2416 Scin 103715_at U04354 scinderin12283 0.98352 1.01 up Mm.59353 Prm3 162056_f_at AV269062 protamine 312284 0.98364 1.01 up 102738_s_at U0798212285 0.98370 1.00 down Mm.4560 Lrpap1 100086_at D00622 low density lipoprotein receptor-related protein associated protein 112286 0.98375 1.00 down Mm.3069 4632403N06Rik 160827_at AI835968 RIKEN cDNA 4632403N06 gene12287 0.98402 1.01 up Mm.5265 2310016M24Rik 162301_f_at AV034726 RIKEN cDNA 2310016M24 gene12288 0.98410 1.01 up Mm.24700 Cdh13 104743_at AB022100 cadherin 1312289 0.98421 1.00 down Mm.2238 Eif3 94250_at U14172 eukaryotic translation initiation factor 312290 0.98428 1.00 up Mm.22418 Pex5 104318_at Z97018 peroxin 512291 0.98435 1.01 down Mm.28647 1500010J02Rik 160787_at AW124900 RIKEN cDNA 1500010J02 gene12292 0.98439 1.01 up Mm.4466 Epha5 98376_at U07357 Eph receptor A512293 0.98441 1.01 up Mm.24075 Mm.24075 103704_at AW047625 ESTs12294 0.98458 1.01 down Mm.1070 Fech 92595_r_at M61215 ferrochelatase12295 0.98459 1.01 down Mm.31395 Cpe 99643_f_at X61232 carboxypeptidase E12296 0.98473 1.01 down Mm.19806 Hdac2 160643_at U31758 histone deacetylase 212297 0.98483 1.01 down Mm.41331 1110012E06Rik 104433_at AI849682 RIKEN cDNA 1110012E06 gene12298 0.98492 1.00 up Mm.22030 Ha1r-pending 104125_at AA763673 Hoxa1 regulated gene12299 0.98504 1.00 down Mm.1639 Mcl1 93093_at U35623 myeloid cell leukemia sequence 112300 0.98513 1.01 down Mm.5189 Pla2g2c 99326_at U18119 phospholipase A2, group IIC12301 0.98522 1.01 down Mm.3488 Stk5 98469_at D21099 serine/threonine kinase 512302 0.98525 1.01 down Mm.2893 Nos2 104420_at U43428 nitric oxide synthase 2, inducible, macrophage12303 0.98527 1.00 up Mm.181852 1200015P04Rik 96672_at AW123564 RIKEN cDNA 1200015P04 gene12304 0.98538 1.00 up Mm.27327 Copb1 94992_at AI840667 coatomer protein complex, subunit beta 112305 0.98562 1.01 up Mm.214752 Actn1 92280_at AA867778 actinin, alpha 112306 0.98580 1.00 up Mm.512 Wbp5 100522_s_at U92454 WW domain binding protein 512307 0.98606 1.00 up 92394_f_at AB01026612308 0.98620 1.01 up Mm.43711 Tbp 99950_at D01034 TATA box binding protein12309 0.98636 1.01 down Mm.41650 Stau1 103872_r_at AA667323 staufen (RNA binding protein) homolog 1 (Drosophila)12310 0.98687 1.01 down Mm.5264 Mm.5264 162435_f_at AV341856 ESTs, Highly similar to FEZ1_RAT FASCICULATION AND ELONGATION P12311 0.98692 1.00 up Mm.12436 2010300K22Rik 102399_at AW123909 RIKEN cDNA 2010300K22 gene12312 0.98702 1.01 up Mm.183022 D8Bwg1112e 93802_at AA815890 DNA segment, Chr 8, Brigham & Women's Genetics 1112 expressed12313 0.98712 1.01 up Mm.42956 Nelf 99557_at AI849565 nasal embryonic LHRH factor12314 0.98733 1.01 down Mm.18459 Fin14 161273_f_at AV322895 fibroblast growth factor inducible 1412315 0.98737 1.00 down Mm.7508 Bcrp1-pending 101105_at AB025349 breakpoint cluster region protein 112316 0.98751 1.01 up Mm.12890 Gpr33 94184_at AF045766 G protein-coupled receptor 3312317 0.98755 1.00 down Mm.6208 Alx4 101622_at AF001465 aristaless 412318 0.98759 1.00 up Mm.29675 Txnl2 95696_at AI840882 thioredoxin-like 212319 0.98766 1.00 down Mm.29543 D17Wsu166e 97330_at AI840499 DNA segment, Chr 17, Wayne State University 166, expressed12320 0.98776 1.00 down 104300_at AI11793612321 0.98788 1.01 up Mm.182650 2610209M04Rik 161236_r_at AV266956 RIKEN cDNA 2610209M04 gene12322 0.98809 1.00 down Mm.38184 Dr1 160449_at AW122207 down-regulator of transcription 112323 0.98866 1.00 up Mm.19788 Klf9 93527_at Y14296 Kruppel-like factor 912324 0.98875 1.01 down Mm.4933 Mcmd6 100149_at D86726 mini chromosome maintenance deficient 6 (S. cerevisiae)12325 0.98884 1.01 up Mm.10160 AA960172 161621_r_at AV355874 expressed sequence AA96017212326 0.98894 1.01 down Mm.18589 2810406K24Rik 103375_at AW050290 RIKEN cDNA 2810406K24 gene12327 0.98909 1.01 up Mm.42160 Bmp15 92485_at AJ010259 bone morphogenetic protein 1512328 0.98924 1.00 up Mm.212538 H2-Q8 101658_f_at D90146 histocompatibility 2, Q region locus 812329 0.98958 1.01 up Mm.1339 Chgb 92842_r_at X51429 chromogranin B12330 0.98965 1.01 down Mm.3546 Mm.3546 92255_at M36654 Mouse homeo box 2.6 (Hox-2.6) mRNA, complete cdsPage 137 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description12331 0.98972 1.00 up Mm.18972 2410174K12Rik 93366_r_at AI838149 RIKEN cDNA 2410174K12 gene12332 0.98979 1.01 down Mm.1987 Dcn 93534_at X53929 decorin12333 0.98993 1.01 up Mm.4922 Csf2 92948_at X03020 colony stimulating factor 2 (granulocyte-macrophage)12334 0.99008 1.00 up Mm.42193 Spin 99563_at AW124681 spindlin12335 0.99023 1.00 down Mm.2375 Ckmm 160175_at X03233 creatine kinase, muscle12336 0.99029 1.01 down Mm.219641 Mm.219641 161440_r_at AV350152 Mus musculus, Similar to hypothetical protein MGC2705, clone MGC:3647112337 0.99032 1.01 up Mm.5621 D6Ertd47e 99363_at C77554 DNA segment, Chr 6, ERATO Doi 47, expressed12338 0.99042 1.00 up Mm.18268 Clk2 103346_at AF033564 CDC-like kinase 212339 0.99055 1.01 down Mm.2552 Reg3a 161642_f_at AV067633 regenerating islet-derived 3 alpha12340 0.99060 1.00 down Mm.20826 Gspt2 103261_at AB003503 G1 to phase transition 212341 0.99061 1.00 up Mm.10 Srm 102562_at Z80833 spermidine synthase12342 0.99067 1.00 up Mm.21198 Gjb1 93771_at X84215 gap junction membrane channel protein beta 112343 0.99070 1.01 down Mm.4137 Chga 92422_at M64278 chromogranin A12344 0.99071 1.01 up Mm.44848 5730437E04Rik 92670_at AW046857 RIKEN cDNA 5730437E04 gene12345 0.99108 1.01 down 101798_at AF07811212346 0.99116 1.00 down Mm.200919 AI450287 161596_f_at AV292740 expressed sequence AI45028712347 0.99145 1.00 up Mm.15918 Map3k1 103022_at U23470 mitogen activated protein kinase kinase kinase 112348 0.99150 1.01 down Mm.3216 Nfe2 98010_at L09600 nuclear factor, erythroid derived 2, 45 kDa12349 0.99151 1.00 down Mm.309 Mm.309 96598_at AA122714 ESTs12350 0.99155 1.00 down Mm.18962 Catna1 161254_r_at AV319727 catenin alpha 112351 0.99156 1.00 up Mm.7001 AA589418 101668_at AA589418 expressed sequence AA58941812352 0.99191 1.00 down Mm.4184 Zfp1 92443_i_at X16493 zinc finger protein 112353 0.99194 1.00 down Mm.12180 AW548096 102383_at AW048977 expressed sequence AW54809612354 0.99201 1.00 up Mm.3441 Ryr3 101830_at X83934 ryanodine receptor 312355 0.99206 1.00 up Mm.142518 Btd 95469_at AA734444 biotinidase12356 0.99211 1.00 down Mm.28638 Sh3bgr 96204_at AJ239082 SH3-binding domain glutamic acid-rich protein12357 0.99214 1.00 up Mm.21401 Nedd4b 103906_f_at AI840868 neural precursor cell expressed, developmentally down-regulated gene 4b12358 0.99256 1.00 down Mm.3848 7420700M05Rik 162265_r_at AV359728 RIKEN cDNA 7420700M05 gene12359 0.99281 1.00 down Mm.9621 1700048E23Rik 101978_at AI840329 RIKEN cDNA 1700048E23 gene12360 0.99295 1.00 up Mm.29415 1810011O01Rik 95132_r_at AI852592 RIKEN cDNA 1810011O01 gene12361 0.99300 1.00 down Mm.23020 Kcnk8 95381_at AF022820 potassium channel, subfamily K, member 812362 0.99387 1.00 up Mm.5591 D8Ertd107e 101224_at C77236 DNA segment, Chr 8, ERATO Doi 107, expressed12363 0.99390 1.00 up Mm.8369 Hgfl 100286_at M74180 hepatocyte growth factor-like12364 0.99399 1.00 down Mm.22514 0610008F14Rik 161494_f_at AV090776 RIKEN cDNA 0610008F14 gene12365 0.99399 1.00 down Mm.4299 Mut 99613_at X51941 methylmalonyl-Coenzyme A mutase12366 0.99419 1.00 down Mm.24025 Stag2 104595_at AI846890 stromal antigen 212367 0.99420 1.00 down Mm.27454 Prps1 95507_at AB025048 phosphoribosyl pyrophosphate synthetase 112368 0.99424 1.00 down Mm.1350 Ipp 94699_at X58523 IAP promoted placental gene12369 0.99438 1.00 down Mm.6522 Cmkor1 93430_at AF000236 chemokine orphan receptor 112370 0.99453 1.00 up Mm.218744 1700012P16Rik 161080_f_at AA726188 RIKEN cDNA 1700012P16 gene12371 0.99453 1.00 down Mm.5249 Cpne6 93151_at AB008893 copine 612372 0.99463 1.00 down Mm.28017 Fbxw1b 93634_at AW125157 F-box and WD-40 domain protein 1B12373 0.99469 1.00 down Mm.86421 Cldn6 93703_at AF087824 claudin 612374 0.99504 1.00 up Mm.2816 Art5 161649_f_at AV088635 ADP-ribosyltransferase 512375 0.99508 1.00 up Mm.143768 Fbxo3 160168_at AW125686 f-box only protein 312376 0.99516 1.00 down Mm.205996 AA087124 161359_s_at AV212934 EST AA08712412377 0.99518 1.00 down Mm.4514 Aldh1a1 161956_at AV364015 aldehyde dehydrogenase family 1, subfamily A112378 0.99520 1.00 down Mm.3063 Ptn 97474_r_at D90225 pleiotrophin12379 0.99521 1.00 down Mm.57129 Ifna5 101791_f_at X01971 interferon alpha family, gene 512380 0.99534 1.00 up Mm.218494 D3Wsu161e 161426_at AV298323 DNA segment, Chr 3, Wayne State University 161, expressed12381 0.99537 1.00 down Mm.20428 Scgf 103244_at AB009245 stem cell growth factor12382 0.99566 1.00 down Mm.2594 Inhbc 103986_at X90819 inhibin beta-C12383 0.99566 1.00 down Mm.21759 Rab12 104082_at AI848325 RAB12, member RAS oncogene family12384 0.99573 1.00 down Mm.5548 D17Ertd141e 99360_at AW048989 DNA segment, Chr 17, ERATO Doi 141, expressed12385 0.99576 1.00 down Mm.1043 AI256744 102233_at AI553401 EST AI25674412386 0.99590 1.00 down Mm.182271 1300003G02Rik 161554_r_at AV252456 RIKEN cDNA 1300003G02 gene12387 0.99596 1.00 down Mm.25087 Mm.25087 96390_at C80774 ESTs12388 0.99607 1.00 down Mm.31570 Kcnk2 104652_at AI849601 potassium channel, subfamily K, member 212389 0.99620 1.00 down Mm.19182 Hpn 160639_at AF030065 hepsin12390 0.99625 1.00 down Mm.12912 Shyc 102752_at AF072697 selective hybridizing clone12391 0.99625 1.00 down 94074_at X6092912392 0.99646 1.00 down Mm.154979 Plac1 162117_f_at AV368791 placental specific protein 112393 0.99647 1.00 down Mm.1381 Zp3 102675_at M20026 zona pellucida glycoprotein 312394 0.99653 1.00 up Mm.43841 AI647584 98353_at AI647548 expressed sequence AI64758412395 0.99674 1.00 down Mm.44219 2310005B10Rik 100037_at AW213225 RIKEN cDNA 2310005B10 gene12396 0.99739 1.00 up Mm.6047 2410002E02Rik 161653_f_at AV096139 RIKEN cDNA 2410002E02 gene12397 0.99739 1.00 up Mm.28491 AU018239 97915_at AW124144 expressed sequence AU01823912398 0.99751 1.00 up Mm.5873 D1Ertd259e 101606_at C79749 DNA segment, Chr 1, ERATO Doi 259, expressed12399 0.99775 1.00 up Mm.12914 Usp2 92820_at AI846522 ubiquitin specific protease 212400 0.99776 1.00 up Mm.29442 Mm.29442 96837_at AI837492 Mus musculus, clone IMAGE:3487794, mRNA, partial cds12401 0.99790 1.00 up Mm.27836 Tacc3 97238_at AW209238 transforming, acidic coiled-coil containing protein 312402 0.99795 1.00 up Mm.21990 Jup 104121_at M90365 junction plakoglobin12403 0.99800 1.00 up Mm.2539 Mth1 161300_r_at AV349001 mutT (E. coli) human homolog (8-oxo-dGTPase)12404 0.99816 1.00 down Mm.4049 Xpa 161552_i_at AV252246 xeroderma pigmentosum, complementation group A12405 0.99816 1.00 up Mm.3458 Rpo1-1 160426_at D31966 RNA polymerase 1-1 (40 kDa subunit)12406 0.99855 1.00 down Mm.29795 Epcs3-pending 95756_at AI839681 ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm12407 0.99855 1.00 up Mm.19390 AI648252 160640_at AW121625 expressed sequence AI64825212408 0.99855 1.00 down Mm.21325 Coch 103317_at AF006741 coagulation factor C homolog (Limulus polyphemus)12409 0.99860 1.00 up Mm.322 Mbd2 160833_at AF072243 methyl-CpG binding domain protein 212410 0.99860 1.00 up Mm.35460 Mm.35460 97162_at AI451676 ESTs12411 0.99884 1.00 up Mm.22583 2410008H17Rik 104358_at AI853668 RIKEN cDNA 2410008H17 gene12412 0.99889 1.00 down Mm.140243 2010012D11Rik 161804_r_at AV369984 RIKEN cDNA 2010012D11 gene12413 0.99896 1.00 up Mm.80 Afp 101493_at M16395 alpha fetoprotein12414 0.99909 1.00 down Mm.3992 Wap 102931_at V00856 whey acidic protein12415 0.99918 1.00 down Mm.1635 Pias3 160615_at AI835963 protein inhibitor of activated STAT 312416 0.99920 1.00 up Mm.27711 1700037H04Rik 97210_at AW048446 RIKEN cDNA 1700037H04 gene12417 0.99961 1.00 up Mm.29409 4933428G09Rik 104447_r_at AI595812 RIKEN cDNA 4933428G09 gene12418 0.99967 1.00 up Mm.28149 3110003A17Rik 96135_at AA833425 RIKEN cDNA 3110003A17 gene12419 0.99977 1.00 up Mm.41981 Defb2 97782_at AJ011800 defensin beta 212420 0.99981 1.00 up Mm.28362 AI326478 100682_f_at U62386 expressed sequence AI326478Page 138 of 139
<strong>Supplementary</strong> <strong>Information</strong><strong>Rank</strong> <strong>Prob</strong> (t-<strong>test</strong>) Foldchange Direction Unigene ID Abreviation Affymetrix ID Accession Description12421 0.99991 1.00 down Mm.10200 1810037C20Rik 102042_at AI842308 RIKEN cDNA 1810037C20 gene12422 0.99993 1.00 down Mm.4706 Gabrb1 92749_at U14418 gamma-aminobutyric acid (GABA-A) receptor, subunit beta 1Page 139 of 139
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