Bosi TKI in cGVHD SIES 2011 per Bosi.ppt [Sola lettura] - siesonline

More documents

Recommendations

Info

Blood 2007 like Scleroderma, also patients with cGVHhave stimulatory antibodies against PDGF-R. These Abs were present in all (22) patients withcGVH and never in patients (17) without GVH.These Abs induce type I collagen and ROSproduction, converting the normal fibroblastsphenotype to SSc-like fibroblast.
B-Lymphoc. RITUXIMABPDGFRImatinibPOSSIBLE TARGETSRasROSMEKFarnesil-transferase InihbitorsOxidant Scav.(NAC)complexNADPHoxStatinsERK 1/2Transcrip. of inflammatoryGenes or/and collagen genes
Page 1: Ematologia traslazionaleRazionale b
Page 4: Continuous oxidative stress transfo
Page 9 and 10: anti-TGF-b Abs can significantly re
Page 12 and 13: …the first observation in manwith
Page 14 and 15: Treatment scheduleand response crit
Page 17 and 18: Updated sept 2010Overall RR: 72%No
Page 19 and 20: Clinical response andoutcomeFOLLOW-
Page 21 and 22: 51 st ASH Annual Meeting ♦ New Or
Page 23 and 24: Results: toxicityHEMATOLOGYCAL TOXI
Page 25 and 26: Steroid dose modifications during I
Page 27 and 28: Cumulative incidence of treatment f
Page 29 and 30: OS according to age (>/40Kaplan-Mei
Page 31 and 32: OS according to skin involvement51
Page 33 and 34: Dasatinib and nilotinib potentlyred
Page 35 and 36: NILOTINIB for steroid-refractorycGV
Page 37 and 38: Effects of Imatinib on T-cells• M
Page 39 and 40: AknowledgementsArmando Gabrielli#Si

Bosi TKI in cGVHD SIES 2011 per Bosi.ppt [Sola lettura] - siesonline

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?