a review on synthesis and biological activity of ... - eJManager.com
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a review on synthesis and biological activity of ... - eJManager.com
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Basedia et al., American Journal <strong>of</strong> PharmTech Research. 2011; 1(4): 174-193. ISSN: 2249-3387<br />
HO<br />
HO<br />
O<br />
185 www.ajptr.<strong>com</strong><br />
N<br />
R<br />
N R 1<br />
N N<br />
24. Synthesized chalc<strong>on</strong>es pyrazolines, isoxazolines <strong>and</strong> aminopyrimidines as <strong>biological</strong><br />
potent agents. Antibacterial <strong>activity</strong> performed <strong>on</strong> gram-positive <strong>and</strong> gram-negative<br />
bacteria . 20<br />
N<br />
H<br />
N<br />
HN<br />
N<br />
N<br />
N<br />
H<br />
R 2<br />
N NH<br />
25. Evaluated the in-vitro cytotoxic activities <strong>of</strong> 2-Alkyl-4,6-diheteroalkyl-1,3,5-triazines.<br />
Cytotoxic activities were carried out against leukemia <strong>and</strong> adenocarcinoma derived cell<br />
lines. 34<br />
N<br />
N<br />
Z Z<br />
26. Synthesized series <strong>of</strong> Diaryltriazines <strong>and</strong> Diarylpyrimidines which were found to have<br />
R<br />
highly potent N<strong>on</strong>nucleoside Reverse Transcriptase Inhibitory acti<strong>on</strong> with possible<br />
applicati<strong>on</strong>s as microbicides. An in-vitro model <strong>of</strong> m<strong>on</strong>ocyte-derived dendritic cells<br />
(MO-DC) <strong>and</strong> CD4 + T cells, representing the primary targets <strong>of</strong> sexual human<br />
immunodeficiency virus (HIV) transmissi<strong>on</strong>, was used to evaluate the antiviral <strong>and</strong><br />
immune suppressive <strong>activity</strong> <strong>of</strong> new classes <strong>of</strong> n<strong>on</strong>-nucleoside reverse transcriptase<br />
inhibitors. 16<br />
N<br />
F<br />
R
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