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Basedia et al., American Journal <strong>of</strong> PharmTech Research. 2011; 1(4): 174-193. ISSN: 2249-3387<br />
LITERATURE ON BIOLOGICAL ACITIVITY STUDIES OF DIFFERENT TRIAZINE<br />
DERIVATIVE<br />
1. Synthesized <strong>and</strong> evaluated <strong>biological</strong> <strong>activity</strong> <strong>of</strong> novel 1,3,5-triazine derivatives as<br />
antimicrobial agents. Numerous studies have c<strong>on</strong>tributed to the development <strong>of</strong> natural<br />
<strong>and</strong> synthetic antimicrobial peptides as a prospective source <strong>of</strong> antibiotic agents. Based<br />
<strong>on</strong> the c<strong>on</strong>cept that cati<strong>on</strong>ic charge, bulk, <strong>and</strong> lipophilicity are major factors determining<br />
antibacterial <strong>activity</strong> in these peptides, designed <strong>and</strong> screened several <strong>com</strong>binatorial<br />
libraries based <strong>on</strong> 1,3,5-triazine as a template. A set <strong>of</strong> <strong>com</strong>pounds were identified to<br />
show potent antimicrobial <strong>activity</strong> together with low hemolytic <strong>activity</strong>. 4<br />
2. Synthesized <strong>and</strong> performed bio-evaluati<strong>on</strong> <strong>of</strong> hybrid 4-aminoquinoline triazines as a new<br />
class <strong>of</strong> antimalarial agents. The emergence <strong>and</strong> rapid spread <strong>of</strong> chloroquine resistant<br />
strains <strong>of</strong> Plasmodium falciparum has dramatically reduced the chemotherapeutic<br />
opti<strong>on</strong>s. Towards this goal, a series <strong>of</strong> new class <strong>of</strong> hybrid 4-aminoquinoline triazines<br />
were synthesized <strong>and</strong> screened against CQ sensitive strain 3D7 <strong>of</strong> P. falciparum in an in-<br />
vitro model. 5<br />
Cl<br />
HN<br />
N<br />
N N<br />
This is synthesize <strong>com</strong>pound c<strong>on</strong>taining 1,3,5-triazine show antimalarial <strong>activity</strong><br />
3. Antiproliferative <strong>activity</strong> <strong>of</strong> the synthesized l,2,4-triazolo[1,5-a][1,3,5]triazines were<br />
evaluated against breast, col<strong>on</strong> <strong>and</strong> lung cancer cell lines. The highest antiproliferative<br />
<strong>activity</strong> in the series was found for 2-(pyridine-3-yl)-7-(4-trifluoromethylphenyl)-6,7-<br />
dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-amine. 6<br />
179 www.ajptr.<strong>com</strong><br />
N<br />
N<br />
N<br />
N<br />
N<br />
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