Atravet™ Soluble Granules - Boehringer Ingelheim Vetmedica

Atravet® Soluble Granules February 16, 2010Chemical Name EC No. CAS- No. Concentration Classification NotesPolyethylene glycol 500-038-2 25322-68-3

Atravet® Soluble Granules February 16, 2010Environmental Precautions: Prevent runoff from entering drains, sewers or streams. Dike forlater disposal.7 HANDLING AND STORAGEHandling: HANDLING SIGNIFICANT QUANTITIES OF PRODUCT: Avoid breathing dust.Avoid contact with eyes, skin or clothing. Use adequate ventilation. Wash hand thoroughly afterhandling.Storage: Keep only in the original container. Store at 15°-30° C (59°-86° F). Store out of directsunlight. Store away from foodstuffs.8 EXPOSURE CONTROLS / PERSONAL PROTECTIONExposure Limits:Chemical Name Source Type Exposure Limits NotesPolyethylene glycols AIHA WEELs 8-HR TWA 10 mg/m 3 ----(as a particulate)Acepromazine maleate BIVI ECL 50 ug/m3 ----Where lower governmentally imposed exposure limits exist, such limits should take precedence.Engineering Controls: Not generally required when handling containers. Good ventilation(typically 10 air changes per hour) should be used. Ventilation rates should be matched toconditions. If applicable, use process enclosures, local exhaust ventilation, or other engineeringcontrols to maintain airborne levels below recommended exposure limits. If exposure limits havenot been established, maintain airborne levels to an acceptable level.Respiratory Protection: Not generally required when handling containers. If engineeringcontrols do not maintain airborne concentrations below recommended exposure limits (whereapplicable) or to an acceptable level (in countries where exposure limits have not beenestablished), an approved respirator must be worn. In the United States of America, if respiratorsare used, a program should be instituted to assure compliance with OSHA standard 63 FR 1152,January 8, 1998. Respirator type: NIOSH approved particulate respirator.Europe: Wear appropriate personal protective equipment according to the CouncilDirective 89/686/EEC (4) and the appropriate CEN standards.PERSONAL PROTECTIVE EQUIPMENT: Not generally required when handling containers.If containers are compromised or exposure to the mixture is likely wear:Eye Protection: Wear safety glasses with side shields (or goggles).Hand Protection: Wear suitable gloves.Skin Protection: Wear lab coat, apron or appropriate clothing to prevent skin contact.Hygiene Measures: Eye bath, washing facilities4/8

Atravet® Soluble Granules February 16, 20109 PHYSICAL AND CHEMICAL PROPERTIESColor: YellowOdor: No data availableOdor Threshold: No data availablePhysical State: Granular solidpH: No data availableMelting Point: No data availableFreezing Point: Not applicableBoiling Point: Not applicableFlash Point: Not applicable; combustible solidFlammability Limit – Upper (%): No data availableFlammability Limit – Lower (%): No data availableEvaporation rate: Not applicableVapor Pressure: Not applicableVapor Density (Air=1): Not applicableViscosity: Not applicableSpecific Gravity: No data availableSolubility: Easily soluble in cold and hot waterPartition Coefficient (n-Octanol/water): Not applicableAutoignition Temperature: No data availableDecomposition Temperature: No data available10 STABILITY AND REACTIVITYStability: Stable.Conditions to Avoid: High temperaturesIncompatible Materials: Strong oxidizing agents, strong acids, strong basesHazardous Decomposition Products: Carbon dioxide, carbon monoxide, nitrogen oxides, sulfuroxidesPossibility of Hazardous Reactions: Hazardous polymerization will not occur.11 TOXICOLOGICAL INFORMATIONSpecified SubstancesAcute ToxicityChemical NamePolyethylene glycolAcepromazine maleateTest ResultsOral LD50 (rat): >20 g/kgDermal LD50 (rabbit): >50 g/kgOral LD50 (rat): 400 mg/kg5/8

Atravet® Soluble Granules February 16, 2010Listed Carcinogens: None listed.12 ECOLOGICAL INFORMATIONEcotoxicity: No data availablePersistence and degradability: No data availableMobility in soil: No data availableOther adverse effects: No data availableGermany WGK: Polyethylene glycol: ID 279: WGK 1 (slightly water-endangering)13 DISPOSAL CONSIDERATIONSGeneral Information: Dispose of in accordance with local, state, federal, national orinternational regulations.Disposal Methods: No specific disposal method required. Do not empty into drains. Dispose ofthis material and its container in a safe way. Do not contaminate water, food, or feed by disposal.RCRA Information: Not applicable14 TRANSPORT INFORMATIONDOT: Not RegulatedTDG: Not RegulatedADR/RID: Not RegulatedIATA: Not RegulatedIMDG: Not Regulated15 REGULATORY INFORMATIONCanadian Controlled Products Regulations: This product has been classified according to thehazard criteria of the Canadian Controlled Products Regulations, Section 33, and the MSDScontains all required information.WHMIS Classification: Non-controlledInventory StatusThis material is not listed on the following inventories: TSCA, DSL, AICS, EINECS, IECSC, ENCS,PICCS, KECI, and NZIoC. Therefore, it can only be used for TSCA exempt purposes such as R&D orveterinary use.US Regulations6/8

Atravet® Soluble Granules February 16, 2010FEDERAL LAW RESTRICTS THIS DRUG TO USE BY OR ON ORDER OF LICENSEDVETERINARIANS.CERCLA Hazardous Substance List (40 CFR 302.4): None listed.Clean Air Act (CAA) Section 112(r) Accidental Release Prevention (40 CFR 68.130): Nonelisted.Clean Water Act Section 311 Hazardous Substances (40 CFR 117.3): None listed.SARA Title IIISection 302Extremely Hazardous Substance (40 CFR 355, Appendix A): None listed.Section 311/312 (40 CFR 370):X Acute (Immediate) Chronic(Delayed)Fire Reactive PressureGeneratingSection 313 Toxic Release Inventory (40 CFR 372): None listed.State RegulationsCalifornia Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65): Nonelisted.Massachusetts Right-To-Know List: None listed.Minnesota Hazardous Substances List: Polyethylene glycolsNew Jersey Right-To-Know List: None listed.Pennsylvania Right-To-Know List: None listed.Rhode Island Right-To-Know List: None listed.European RegulationsAustria MAK List (Annex I): Polyethylene glycolDenmark (Annex 3.6): None listed.Germany (Dangerous Substances Ordinance 2004, Annex III): None listed.Norway (List of Dangerous Substance): None listed.Sweden (Annex 3): None listed.Switzerland (Toxins List 1): Polyethylene glycol16 OTHER INFORMATIONHazard RatingsHealth Hazard Fire Hazard Reactivity HazardHMIS 2 1 0Health Hazard Fire Hazard Reactivity Hazard Special HazardNFPA 2 1 0 N/A* – Chronic health effect; 0 – Minimal; 1 – Slight; 2 – Moderate; 3 – Serious; 4 – SevereEU Symbol and R Phrase DefinitionsXn – Harmful7/8

Atravet® Soluble Granules February 16, 2010R22 – Harmful if swallowed.ABBREVIATIONS:BIV – Boehringer Ingelheim Vetmedica, Inc.AIHA – American Industrial Hygiene Associationmppcf – million particles/cubic footN/A – Not applicable.N/E – Not established.References:1. Atravet® Soluble Granules MSDS, Package Insert and Carton. Fort Dodge AnimalHealth.2. Ariel WebInsight Regulatory Database. Regulatory Summary for North America,Western Europe, and Global Inventories Database.3. GHS ManualRevision Information: New MSDSPrepared by: Boehringer Ingelheim Vetmedica, Inc.Issue Date: 02/16/2010Disclaimer: The information provided herein is offered by Boehringer Ingelheim Vetmedica, Inc.(“BIV”) in good faith as accurate as of the date hereof, but without guarantee. This informationincludes information which has been generated by other parties and provided to BIV, and whichBIV has not independently verified. The information provided herein relates only to the specificproduct designated, and may not be valid where such product is used in combination with anyother materials or in any process. The information provided herein is offered solely for yourconsideration, investigation and verification, and Boehringer Ingelheim Vetmedica, Inc. (“BIV”)expressly disclaims all liability for reliance thereon. BIV EXPRESSLY DISCLAIMS ALLWARRANTIES OF EVERY KIND AND NATURE (INCLUDING WARRANTIES OFMERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE) WITH RESPECTTO THE USE OR SUITABILITY OF THE PRODUCT. In addition, since the conditions of useand suitability of the product for particular uses are beyond BIV’s control, ALL RISKS OF USEOF THE PRODUCT ARE THEREFORE ASSUMED BY THE USER, AND BIV EXPRESSLYDISCLAIMS ANY AND ALL LIABILITY AS TO ANY RESULTS OBTAINED ORARISING FROM ANY USE OF THE PRODUCT. Use or transmission of the informationcontained herein in any other format than the format as presented is strictly prohibited. Nothingherein shall be construed as permission or recommendation for the use of the product in a mannerthat might infringe an existing patent. BIV neither represents nor warrants that the format, contentor product formulas contained in this document comply with the laws of any other country exceptthe United States of America.© Copyright 2010 Boehringer Ingelheim Vetmedica, Inc. All rights reserved.8/8