Studying the effects of PFOA contamination on the health of the ...

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<strong>PFOA</strong> half life•Half life in humans estimated at 4 years based on 243M workers. Not well established. Not clear whe<strong>the</strong>r<strong>the</strong>re is a large excretion slowly followed by a slowerexcretion.•Not metabolized in people, stored in liver, kidney, andserum before excretion.
<strong>PFOA</strong> animal data•<strong>PFOA</strong> causes pancreatic, testicular, liver, and perhapsbreast cancer in rodents, but is not genotoxic/mutagenic.•It also causes non malignant liver disease andimmunotoxicity in rats (decreased spleen/thymus weight)•Low birthweight and fetal loss in mice
Page 2 and 3: Slide 1s1 sbody, 13/05/2009s2 sbody
Page 5 and 6: PFOA and PFOS in s
Page 7: PFOA at Dupont pla
Page 13 and 14: PFOA human levels
Page 15: PFOA workers level
Page 19 and 20: Health effects: Mo
Page 21 and 22: Other results amon
Page 23 and 24: The C8 Science Panel3 Established E
Page 25 and 26: PFOA Research Prog
Page 27 and 28: 1. Cross sectional study cholestero
Page 29 and 30: 212210208Predicted Total Cholestero
Page 31 and 32: Cholesterol resultsCannot draw conc
Page 33 and 34: Results for Preeclampsia:Adjusted O
Page 35 and 36: • No relationship found for misca
Page 37 and 38: C8 Half Life Study• How long does
Page 39 and 40: C8 Half Life Study Update:Prelimina
Page 41 and 42: Geographic (ecologic) study <strong
Page 43 and 44: C8 Past exposure study• How much
Page 45 and 46: C8 Community follow-up study• Fou
Page 47 and 48: C8 Worker follow-up study• Four y
Page 49 and 50: Time line• 2008-9: Results <stron

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