Primary FRCA exam January 2010

Primary FRCA exam January 2010Pharmacology1) Tell me how NSAIDS work?Drew diagram of pathway. Effects. Uses. Side effects. Why does aspirin’s antiplateleteffect last 7 days?2) What are Ach receptors? What types. Where are they found.?Discussed nicotinic Ach Rs in the autonomic ganglia and NMJ, and muscarinic Ach Rsin the PNS. How do they work (Ligand gated ion channels/ GPCRs). Different ligands- egatropine. Ipratropium. Uses and effects.3) What are the characteristics of the ideal colloid? Colloids vs crystalloids. Starches vsgelatins.Physiology1) Given a drawing of the Oxygen dissociation curve. Mark on 3 points- arterial blood(with normal pKa range), mixed venous blood and p50. What is the purpose of thep50 value. What causes right shift? Had to calculate O2 content of blood and O2delivery. What is huffners constant? To calculate dissolved O2 in blood, why do wemultiply PaO2 by 0.0225? What happens to O2 content at altitude? What happens inhyperbaric situation eg 10m below sea level.2) What is the role of Ca2+ in the body? How is it regulated? Vitamin, PTH3) How is blood pressure controlled? What is the body’s response to losing 15%circulating volume bloodClinical scenario25 year old primigravida 39/40. Sudden foetal distress. Had not required epidural up untilthen. Discussed management options. How would I anaesthetise this pt for emergencyLSCS. Physiological changes in pregnancy/special considerations. Critical incident:difficult intubation. Sats drop afterwards- possible causes. Management of aspiration.Physics19