General Meeting In<strong>for</strong>mationOral AbstractsThe iSBTc has selected the highest scoring abstract entries <strong>for</strong>oral presentations within the various meeting sessions. Each oralabstract presentation is followed by a five-minute question andanswer period. For a complete listing <strong>of</strong> the selected oral abstractpresenters, please see page 25.Poster AbstractsAbstracts selected <strong>for</strong> poster presentation <strong>for</strong> the 23rd AnnualMeeting are on display at various times on the 4th Floor in theGarden Pavilion.Posters in the categories <strong>of</strong>: Adoptive Transfer; Dendritic Cells;Endpoints, Response Criteria <strong>for</strong> Clinical Trial Design; Enhancing<strong>Cancer</strong> Vaccines; and TH-17, Cytokines and T Cell Subsets (#1-72)will be presented from 12:00 PM – 1:00 PM and 5:30 PM – 6:30PM on Friday and available <strong>for</strong> viewing from 10:00 AM – 7:30 PMon Friday.Posters in the categories <strong>of</strong>: <strong>Cancer</strong> and Inflammation; <strong>Cancer</strong> StemCells and the Host Response; Co-stimulation / Immunoregulation;Infectious Agent Vectors; Innate Immunity to Tumors; New Agents;Trafficking and in vivo Imaging; Tumor Escape / Tumor Microenvironment;Tumor Targeting Monoclonal Antibodies; and Late-BreakingAbstracts (#73-141) will be presented from 12:00 PM – 1:00 PMand 5:30 PM – 6:30 PM on Saturday and available <strong>for</strong> viewing from10:00 AM – 7:15 PM on Saturday. Please see page 54 or the PosterAbstract Book <strong>for</strong> this year’s poster listings. During the presentationtimes listed, designated posters are staffed by their respective authors,allowing <strong>for</strong> in<strong>for</strong>mation exchange and interaction betweenresearchers and attendees.Poster Hall HoursFriday Posters 10:00 AM – 7:30 PMAdoptive TransferDendritic CellsEndpoints, Response Criteria <strong>for</strong> Clinical Trial DesignEnhancing <strong>Cancer</strong> VaccinesTH-17, Cytokines and T Cell SubsetsLate-Breaking AbstractsTo fulfill iSBTc’s commitment to the most cutting-edge science, latebreakingabstract submission was <strong>of</strong>fered from August – September.The abstracts submitted were not available in time <strong>for</strong> printing in theJournal <strong>of</strong> <strong>Immunotherapy</strong> or consideration <strong>for</strong> oral presentation,but are available <strong>for</strong> viewing as posters on Saturday, November 1 inthe “Late-Breaking Abstract” category. Copies <strong>of</strong> the late-breakingabstracts are also available in the Poster Abstract Book distributedwith the meeting materials.Poster Presentations/Staffing HoursFriday Presentations: 12:00 PM - 1:00 PM & 5:30 PM - 6:30 PMPoster Numbers 1-72 (authors must be present)Adoptive Transfer (1-13)Dendritic Cells (14-21)Endpoints, Response Criteria <strong>for</strong> Clinical Trial Design (22-24)Enhancing <strong>Cancer</strong> Vaccines (25-59)TH-17, Cytokines and T Cell Subsets (60-72)Saturday Presentations: 12:00 PM - 1:00 PM & 5:30 PM - 6:30 PMPoster Numbers 73-141 (authors must be present)<strong>Cancer</strong> and Inflammation (73-77)<strong>Cancer</strong> Stem Cells and the Host Response (78)Co-stimulation / Immunoregulation (79-84)Infectious Agent Vectors (85-87)Innate Immunity to Tumors (88-94)New Agents (95-104)Trafficking and in vivo Imaging (105)Tumor Escape / Tumor Microenvironment (106-125)Tumor Targeting Monoclonal Antibodies (126-129)Late-Breaking Abstracts (130-141)Saturday Posters 10:00 AM – 7:15 PM<strong>Cancer</strong> and Inflammation<strong>Cancer</strong> Stem Cells and the Host ResponseCo-stimulation / ImmunoregulationInfectious Agent VectorsInnate Immunity to TumorsNew AgentsTrafficking and in vivo ImagingTumor Escape / Tumor MicroenvironmentTumor Targeting Monoclonal AntibodiesLate-Breaking Abstracts
Continuing Medical EducationThe iSBTc provides interested physicians the opportunity to earnContinuing Medical Education (CME) credits <strong>for</strong> attending the iSBTcAnnual Meeting, Primer and Workshop. For more in<strong>for</strong>mation onWorkshop and Primer CME, please reference the iSBTc website atwww.isbtc.org or the meeting materials provided to all registeredattendees <strong>of</strong> those programs.(Please note that CME credits are NOT <strong>of</strong>fered <strong>for</strong> the Global RegulatorySummit or the Sunday Hot Topic Symposium).Accreditation StatementThe iSBTc Annual Meeting has been planned and implemented inaccordance with the Essential Areas and Policies <strong>of</strong> the AccreditationCouncil <strong>for</strong> Continuing Medical Education (ACCME) throughthe joint sponsorship <strong>of</strong> the Institute <strong>for</strong> the Advancement <strong>of</strong> HumanBehavior, A Medical Education Company (IAHB-AMEDCO) andthe International <strong>Society</strong> <strong>for</strong> Biological Therapy <strong>of</strong> <strong>Cancer</strong> (iSBTc).IAHB-AMEDCO is accredited by the ACCME to provide continuingmedical education <strong>for</strong> physicians.Designation StatementThe IAHB-AMEDCO designates the iSBTc Annual Meeting <strong>for</strong> amaximum <strong>of</strong> 15.08 AMA PRA Category 1 Credits. Physiciansshould only claim credit commensurate with the extent <strong>of</strong> theirparticipation in the activity.• Friday: 6.5 AMA PRA Category 1 Credits• Saturday: 6.33 AMA PRA Category 1 Credits• Sunday: 2.25 AMA PRA Category 1 CreditsIntended AudienceBasic and clinical investigators involved in cancer research comprisingmembers <strong>of</strong> academic, pharmaceutical, and regulatory agenciesincluding basic scientists, clinicians, graduate students and postdoctoralfellows, as well as allied health pr<strong>of</strong>essionals.<strong>Program</strong> Goals• Promote scientific exchange <strong>of</strong> the most recent advances anddata in the biological treatment <strong>of</strong> cancer, as well as advances inbasic cancer biology with relevance <strong>for</strong> anti-tumor immunity• Promote the generation <strong>of</strong> new ideas incorporating theseadvances and explore their potential <strong>for</strong> impact on treatmentoutcomes• Discuss the latest clinical developments regarding application <strong>of</strong>biologic approaches and establish dialogue between academia,government and industry regarding implications as well as futuredirections• Educate and provide perspective to the audience on the broadrange <strong>of</strong> scientific developments in cancer and biological approachesto therapy• Discuss therapeutic approaches to cancer immunotherapy including:cancer vaccines, adoptive T cell transfer, monoclonal antibodies,gene therapy, and use <strong>of</strong> cytotoxic or molecular targetingagents in combination with immune therapy• Discuss current approaches to immunological monitoring• Discuss current regulatory guidelines and how they impact clinicaltrials as well as resource availabilityExpected Learner OutcomesUpon completion <strong>of</strong> this meeting, participants will be able to:• Summarize the most recent advances in cancer biology, how theyintersect with the immune system, and how these considerationsare relevant <strong>for</strong> the biologic therapy <strong>of</strong> cancer. These include butare not limited to: cancer stem cells, inflammation and cancer,cancer dormancy, and angiogenesis• Discuss the latest in<strong>for</strong>mation about clinical/translational work incancer immunotherapy• Establish how to solidify collaborations among the variousmembers <strong>of</strong> academia, industry, and clinical practices to initiateclinical evaluation <strong>of</strong> these advances in more efficient trials• Compare options available in trial design including immunemonitoring techniques and compliance with regulatoryguidelines• Locate resources available through government agencies (funds,data-bases, tissue banks, etc.) that can facilitate translationalresearchObtaining Your CME CertificatesTo obtain your CME certificate <strong>for</strong> the iSBTc Primer, Workshopand/or Annual Meeting, go to www.CmeCertificateOnline.com.Scroll down to the iSBTc listing and click on the program <strong>for</strong> whichyou are claiming credit. Please note that each <strong>of</strong> the iSBTc programshave separate links and you will need to repeat the process in eachprogram <strong>for</strong> which you are claiming credit.On the certificate site, enter the password ISBTC08CAMP, selectthe sessions/presentations you attended and evaluate variousaspects <strong>of</strong> the program. Your hours will be automatically calculatedbased on the sessions and programs you attend. It is recommendedthat you immediately print your certificate directly from this site. Acopy <strong>of</strong> the certificate will also be e-mailed to you in case you needto print additional copies.The online certificate site will only be available throughDecember 31, 2008. After that date, the site and certificateswill no longer be available. Please address any questions aboutthe process to: Jay Parker; AMEDCO, LLC; Tel: 651-789-3716. ForiSBTc staff assistance, please contact Angela Kilbert atakilbert@isbtc.org or call 414-271-2456.Financial Disclosure In<strong>for</strong>mationPlease see the “Disclosures” section on page 26 <strong>for</strong> complete in<strong>for</strong>mationregarding faculty disclosure <strong>of</strong> financial relationships.