Fanconi Anemia: Diagnosis and Treatment
Fanconi Anemia: Diagnosis and Treatment
Fanconi Anemia: Diagnosis and Treatment
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Cancer Cells are often defective in one DNARepair PathwayNormal cellsCancer cells+ + + + + + − + + + + +Six normal DNArepair pathwaysKennedy <strong>and</strong> D’Andrea, J.C.O. 24: 3799, 2006BBRCA1mutationPredicts PARPisensitivity ofbreast cancerThe specific pathway lostmay determine the bestcourse of chemotherapy<strong>and</strong> radiation(personalized medicine)