Fanconi Anemia: Diagnosis and Treatment

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Cancer Cells are often defective in one DNARepair PathwayNormal cellsCancer cells+ + + + + + + + + + +MGMTsilencingPredicts TMZsensitivity ofbrain cancerSix normal DNArepair pathwaysKennedy and D’Andrea, J.C.O. 24: 3799, 2006The specific pathway lostmay determine the bestcourse of chemotherapyand radiation(personalized medicine)
Using Synthetic Lethalityto treat tumors withUnderlying defects in theFanconi Anemia Pathway
Page 3:
Fanconi anemia history• Named aft
Page 6 and 7:
Image courtesyDr Blanche Alter
Page 9 and 10:
Image courtesyDr Blanche Alter
Page 12 and 13:
Fanconi Anemia: Cellular phenotype
Page 14 and 15:
Chromosome breakage read-outML# Ref
Page 16:
The Fifteen Fanconi Anemia GenesGen
Page 19:
The Fifteen FA proteins regulate DN
Page 24 and 25: BRCA2 is a Fanconi Anemia Gene (D1)
Page 26 and 27: In BRCA2 kindreds:dParadoxBRCA2 (+/
Page 28 and 29: Natural history of FA• Birth defe
Page 32 and 33: Pathophysiology• DNA repair Bone
Page 34 and 35: Treatment of Fanconi AnemiaAndrogen
Page 36 and 37: 100%90%Unrelated Donor BMT for FASu
Page 38 and 39: New treatments are badly needed•
Page 40 and 41: Alan D’AndreaJohn PostlethwaitMar
Page 42: mammary AC10 moovarian AC13 momamma
Page 45: Properties of tempol• Superoxide
Page 49 and 50: Conclusions• The SOD mimetic temp
Page 51 and 52: From:Maclean KH, Dorsey FC, Clevela
Page 53 and 54: Mean tumor-free survival:Placebo: 1
Page 57: Reduced numbers of stem cells
Page 60: Changes in cell cycle status of ste
Page 70 and 71: SRT3025 (“SirT Diet”) treatment
Page 72 and 73: Cancer Cells are often defective in
Page 76 and 77: Since 5-20 % of solid tumors in the
Page 78 and 79: siRNA Targets Specifically Toxic to
Page 80 and 81: FA Cell Lines Are Hypersensitive to
Page 82: Conclusions:1) Conventional cancer
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Fanconi Anemia: Diagnosis and Treatment

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